locus-tag class description TDE_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) TDE_0002 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TDE_0006 ENOG4105C0D helicase TDE_0010 ENOG41087AY ADP-Ribose pyrophosphatase TDE_0011 ENOG4105D3R alkyl hydroperoxide reductase TDE_0013 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TDE_0016 ENOG4105D1H recombination factor protein RarA TDE_0017 ENOG4105DER m42 family TDE_0019 ENOG4105CKU formyltetrahydrofolate synthetase TDE_0020 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) TDE_0024 ENOG4105D17 glycoside hydrolase, family 3 domain protein TDE_0025 ENOG41062VP TDE_0029 ENOG4105BZ1 (ABC) transporter TDE_0033 ENOG4108NEV two component transcriptional regulator, LytTR family TDE_0038 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TDE_0040 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TDE_0042 ENOG4108IJ2 phosphate acetyltransferase TDE_0043 ENOG4107GWN repeat protein TDE_0044 ENOG4105C5H ABC transporter TDE_0047 ENOG4105CI2 imidazolone-5-propionate hydrolase TDE_0052 ENOG4105VS8 Flagellar biosynthetic protein fliq TDE_0053 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TDE_0054 ENOG4105D00 flagellar biosynthetic protein flhB TDE_0055 ENOG4105D7B Flagellar biosynthesis protein flha TDE_0056 ENOG41068UM RNA Polymerase TDE_0057 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TDE_0064 ENOG4105CTQ phosphohexokinase TDE_0067 ENOG4105IJJ transcriptional regulator, crp fnr family TDE_0068 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) TDE_0069 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein TDE_0070 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TDE_0071 ENOG4105CFP Peptidase U32 TDE_0072 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TDE_0074 ENOG4105D5Q Arginine ornithine antiporter TDE_0075 ENOG4105CPQ Dehydrogenase TDE_0076 ENOG41061GT Aldolase TDE_0077 ENOG4105EZ5 reductase TDE_0080 ENOG4105C26 Dehydrogenase TDE_0083 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TDE_0084 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TDE_0085 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation TDE_0086 ENOG4109031 TDE_0087 ENOG4105C1A potassium transporter peripheral membrane TDE_0088 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) TDE_0089 ENOG4108KS2 transglutaminase domain protein TDE_0092 ENOG4105C8N cysteinyl-tRNA synthetase TDE_0093 ENOG4107QWW Cell wall formation (By similarity) TDE_0099 ENOG4107QMH DNA methylase TDE_0100 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TDE_0103 ENOG4105C3J Cysteine desulfurase TDE_0104 ENOG4105D49 3-dehydroquinate synthase TDE_0105 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TDE_0107 ENOG4105CG3 alpha amylase, catalytic region TDE_0109 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TDE_0110 ENOG4105DR5 peptidase TDE_0112 ENOG4105XVJ Protein of unknown function (DUF327) TDE_0113 ENOG4105MA4 psp1 domain protein TDE_0116 ENOG4105D7X high-affinity nickel-transporter TDE_0118 ENOG4106VWR TDE_0123 ENOG4105Y6R TDE_0125 ENOG4105BZU Histidine kinase TDE_0128 ENOG4105BZU Histidine kinase TDE_0129 ENOG4105CXT aspartate transcarbamylase TDE_0137 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) TDE_0138 ENOG4105D4A Cell wall formation (By similarity) TDE_0145 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TDE_0146 ENOG4105CH2 amidohydrolase TDE_0148 ENOG4105BZU Histidine kinase TDE_0150 ENOG4105EYW Ion transport protein TDE_0153 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TDE_0154 ENOG4105F8J Adenylate Guanylate cyclase TDE_0157 ENOG4108UHU Aldolase TDE_0163 ENOG4108Z29 Flavodoxin TDE_0167 ENOG4105CZV ABC transporter TDE_0169 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0170 ENOG4107RFY SbcCD D subunit TDE_0171 ENOG4105EYH Exonuclease TDE_0172 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TDE_0173 ENOG4105CNU cell division protein FtsK TDE_0174 ENOG4105DAP Nicotinate phosphoribosyltransferase TDE_0175 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) TDE_0178 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0181 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TDE_0183 ENOG4105ECW sulfate abc transporter TDE_0188 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TDE_0189 ENOG4105EJ9 Membrane TDE_0191 ENOG4105TIE Aminoglycoside 2'-N-acetyltransferase TDE_0193 ENOG4105T73 TDE_0200 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) TDE_0204 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TDE_0207 ENOG4105C6Z Gluconate TDE_0208 ENOG4105BZW Glycerate kinase TDE_0209 ENOG4107R3E Citrate transporter TDE_0210 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase TDE_0211 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TDE_0214 ENOG4105G3C Type iv pilus assembly TDE_0230 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TDE_0231 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TDE_0232 ENOG4108UVJ appr-1-p processing domain protein TDE_0233 ENOG4107R3N Filamentation induced by cAMP protein fic TDE_0237 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) TDE_0243 ENOG4108JJB ABC transporter TDE_0244 ENOG4105BZ1 (ABC) transporter TDE_0245 ENOG4105BZ1 (ABC) transporter TDE_0248 ENOG4105K78 MarR family Transcriptional regulator TDE_0250 ENOG4105C8J )-transporter TDE_0251 ENOG4105C0F tryptophanase EC 4.1.99.1 TDE_0255 ENOG4108JJB ABC transporter TDE_0258 ENOG4107Y6J Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) TDE_0267 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TDE_0273 ENOG4105BZ1 (ABC) transporter TDE_0279 ENOG4107SKW Inherit from COG: Alpha beta hydrolase TDE_0282 ENOG4108JJB ABC transporter TDE_0285 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TDE_0286 ENOG4105BZ1 (ABC) transporter TDE_0292 ENOG4105D6S protein involved in catabolism of external DNA TDE_0294 ENOG4107ZYR domain protein TDE_0295 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TDE_0296 ENOG4105CCS Glutamate formiminotransferase TDE_0299 ENOG4105M6F mutator MutT protein TDE_0300 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TDE_0305 ENOG4105C3G gtp-binding protein TDE_0306 ENOG4105D07 Signal peptide peptidase, SppA TDE_0311 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) TDE_0312 ENOG4105CZN Potassium uptake protein TDE_0313 ENOG4107ZYR domain protein TDE_0314 ENOG4106S4G TDE_0316 ENOG4105BZ1 (ABC) transporter TDE_0319 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TDE_0320 ENOG4108JU6 CBS domain protein TDE_0321 ENOG4108JU6 CBS domain protein TDE_0326 ENOG4105C9U ATP-dependent DNA helicase RecQ TDE_0329 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) TDE_0332 ENOG4108IG5 Transcriptional regulator TDE_0335 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TDE_0336 ENOG4105F4G Membrane TDE_0337 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TDE_0339 ENOG4108Q5F Tetr family transcriptional regulator TDE_0340 ENOG4105WYW fructose-bisphosphate aldolase TDE_0341 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TDE_0342 ENOG4105CJR Integral membrane protein (MviN TDE_0345 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0347 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0348 ENOG4107Z3H Transcriptional regulator, TetR family TDE_0350 ENOG4105C3S Mate efflux family protein TDE_0351 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TDE_0352 ENOG4108YZG isomerase TDE_0354 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein TDE_0359 ENOG4105BZ1 (ABC) transporter TDE_0360 ENOG4105BZ1 (ABC) transporter TDE_0361 ENOG4105D6U Sodium Glutamate Symporter TDE_0364 ENOG4105BZ1 (ABC) transporter TDE_0366 ENOG4105DZR Type I site-specific deoxyribonuclease TDE_0370 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) TDE_0373 ENOG4105BZ1 (ABC) transporter TDE_0374 ENOG4105CPK Glycosyl transferase (Group 1 TDE_0375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TDE_0376 ENOG4107RCV ABC transporter, permease TDE_0385 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) TDE_0386 ENOG4105C4Y ABC transporter TDE_0389 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase TDE_0392 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase TDE_0395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_0396 ENOG4105C3U ABC transporter TDE_0397 ENOG4108JQ7 (ABC) transporter TDE_0398 ENOG4105DEF Extracellular solute-binding protein, family 5 TDE_0400 ENOG4105DUM transcriptional regulator, lysR family TDE_0401 ENOG4108T5G Adenylate TDE_0408 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein TDE_0410 ENOG4105D0M Protease HtpX homolog TDE_0411 ENOG4108T5G Adenylate TDE_0431 ENOG4108I7Y domain protein TDE_0434 ENOG4108RAC Rubrerythrin TDE_0435 ENOG4105C9U ATP-dependent DNA helicase RecQ TDE_0436 ENOG410826D Involved in DNA repair and RecF pathway recombination (By similarity) TDE_0438 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) TDE_0448 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TDE_0450 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) TDE_0451 ENOG4105CEU Arginine dihydrolase TDE_0454 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) TDE_0455 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TDE_0456 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) TDE_0462 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TDE_0463 ENOG4105D3A purine nucleoside phosphorylase DeoD-type TDE_0470 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TDE_0475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TDE_0476 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) TDE_0479 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) TDE_0484 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0487 ENOG4105CJ1 ABC, transporter TDE_0492 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TDE_0494 ENOG4108KSB HipA-like N-terminal domain TDE_0505 ENOG4105VXN addiction module toxin, RelE StbE family TDE_0535 ENOG4105C19 ABC transporter TDE_0571 ENOG4105E6M Sulphatase-modifying factor protein TDE_0575 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TDE_0576 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TDE_0577 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TDE_0582 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TDE_0584 ENOG4108PJD permease TDE_0588 ENOG4105C84 Histidine ammonia-lyase TDE_0589 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) TDE_0590 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) TDE_0591 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TDE_0592 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein TDE_0597 ENOG4105RKW reductase (By TDE_0598 ENOG4105CHR reductase TDE_0601 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TDE_0602 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TDE_0606 ENOG4105FA0 parb-like partition protein TDE_0607 ENOG4107QJE Chromosome Partitioning Protein TDE_0610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TDE_0614 ENOG4105CIA precorrin-4 C(11)-methyltransferase TDE_0615 ENOG4108P62 biosynthesis protein (CbiG) TDE_0619 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0620 ENOG4105VVB TDE_0621 ENOG4105UQX Mate efflux family protein TDE_0623 ENOG4105E4R Precorrin-3B C17-methyltransferase TDE_0624 ENOG4108JTQ reductase TDE_0625 ENOG4105E0A ABC, transporter TDE_0627 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TDE_0628 ENOG4105CFG Acts as a chaperone (By similarity) TDE_0629 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TDE_0636 ENOG4108JQ7 (ABC) transporter TDE_0638 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_0639 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TDE_0640 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0641 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TDE_0643 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TDE_0644 ENOG4108IUZ ABC transporter TDE_0647 ENOG4105BZU Histidine kinase TDE_0648 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TDE_0654 ENOG4105CH2 amidohydrolase TDE_0656 ENOG4105EWM Histidine kinase TDE_0660 ENOG4105D29 Helix-turn-helix type 11 domain protein TDE_0662 ENOG4105KRQ Addiction module toxin, Txe YoeB family TDE_0664 ENOG4107QKZ Ompa motb domain protein TDE_0665 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TDE_0666 ENOG4105C3K feS assembly ATPase SufC TDE_0667 ENOG4105DIW FeS assembly protein SUFB TDE_0670 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) TDE_0680 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TDE_0681 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TDE_0682 ENOG4105VIE preprotein translocase, subunit YajC TDE_0685 ENOG4105E1F short-chain dehydrogenase reductase TDE_0686 ENOG4105C8V SAICAR synthetase TDE_0687 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TDE_0689 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) TDE_0690 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TDE_0693 ENOG4105DWF phosphomethylpyrimidine kinase TDE_0694 ENOG4105CJ1 ABC, transporter TDE_0702 ENOG4105CJ1 ABC, transporter TDE_0709 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TDE_0720 ENOG410624X efflux transporter, rnd family, mfp subunit TDE_0725 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TDE_0732 ENOG4105C26 Dehydrogenase TDE_0737 ENOG4105KRQ Addiction module toxin, Txe YoeB family TDE_0744 ENOG41080XV Thioredoxin TDE_0746 ENOG4105E0A ABC, transporter TDE_0747 ENOG4105EHG Permease protein TDE_0749 ENOG4105CTK cobaltochelatase, cobn subunit TDE_0750 ENOG4105EET magnesium chelatase TDE_0751 ENOG4105EET magnesium chelatase TDE_0755 ENOG4105DFD Na H antiporter TDE_0756 ENOG4105E0A ABC, transporter TDE_0757 ENOG4105EHG Permease protein TDE_0765 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TDE_0766 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) TDE_0767 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TDE_0768 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TDE_0769 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TDE_0770 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TDE_0771 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) TDE_0772 ENOG41082G4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) TDE_0773 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TDE_0774 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) TDE_0775 ENOG41086S0 50s ribosomal protein l29 TDE_0776 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TDE_0777 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) TDE_0778 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) TDE_0779 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TDE_0780 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) TDE_0781 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TDE_0782 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TDE_0783 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) TDE_0784 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TDE_0785 ENOG41084HK 50S ribosomal protein L30 TDE_0786 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TDE_0787 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TDE_0788 ENOG41067V7 50S ribosomal protein L36 TDE_0789 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits TDE_0790 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TDE_0791 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TDE_0792 ENOG4108ZT0 50S ribosomal protein l17 TDE_0793 ENOG4106DC9 TDE_0797 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 TDE_0801 ENOG4108Z40 Transcriptional regulator TDE_0802 ENOG4108RYK Nad-dependent epimerase dehydratase TDE_0804 ENOG4105E0Y RtcB Protein TDE_0813 ENOG4105BZ1 (ABC) transporter TDE_0814 ENOG4105KVH Transcriptional regulator TDE_0815 ENOG4105CSX c4-dicarboxylate anaerobic carrier TDE_0816 ENOG4105CH2 amidohydrolase TDE_0818 ENOG4105BZ1 (ABC) transporter TDE_0819 ENOG4105BZ1 (ABC) transporter TDE_0820 ENOG4108IG5 Transcriptional regulator TDE_0823 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TDE_0824 ENOG4105K4I Scp-like extracellular TDE_0825 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TDE_0826 ENOG4106178 UPF0339 protein TDE_0828 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TDE_0829 ENOG4105DFM M18 family aminopeptidase TDE_0833 ENOG4105E6M Sulphatase-modifying factor protein TDE_0834 ENOG4105DGN Electron transport complex TDE_0835 ENOG4105DZB Electron transport complex TDE_0836 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit TDE_0837 ENOG4105D6A Electron transport complex TDE_0838 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) TDE_0839 ENOG4105C72 UPF0176 protein TDE_0841 ENOG4105YQK von Willebrand factor type A domain TDE_0842 ENOG41073RW Cytoplasmic filament protein A TDE_0843 ENOG4108SXE TDE_0844 ENOG4107QJD pyruvate phosphate dikinase TDE_0846 ENOG4105HCZ TDE_0850 ENOG4105C8Q Methyl-accepting chemotaxis TDE_0852 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TDE_0853 ENOG4108UJD 30S ribosomal protein S9 TDE_0854 ENOG410902V Modulates RecA activity (By similarity) TDE_0855 ENOG4108WQH regulatoR TDE_0861 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TDE_0863 ENOG4105KT7 mgtC SapB transporter TDE_0864 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TDE_0870 ENOG4105CGH 5'-nucleotidase TDE_0872 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) TDE_0873 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) TDE_0874 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) TDE_0875 ENOG4105FE9 pseudouridine synthase TDE_0880 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) TDE_0881 ENOG4105K5M 30s ribosomal protein S16 TDE_0882 ENOG4105VB6 UPF0109 protein TDE_0883 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TDE_0884 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TDE_0885 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TDE_0890 ENOG4106N2C TDE_0891 ENOG4105D29 Helix-turn-helix type 11 domain protein TDE_0893 ENOG4108IUW ABC transporter TDE_0895 ENOG4108R6W Transcriptional regulator, ARAC family TDE_0896 ENOG4105BZ1 (ABC) transporter TDE_0897 ENOG4105BZ1 (ABC) transporter TDE_0900 ENOG4108JJB ABC transporter TDE_0903 ENOG4105C4R Atp-dependent dna helicase TDE_0906 ENOG4108JJB ABC transporter TDE_0908 ENOG4105BZ1 (ABC) transporter TDE_0916 ENOG4105BZ1 (ABC) transporter TDE_0921 ENOG4105BZ1 (ABC) transporter TDE_0922 ENOG4105BZ1 (ABC) transporter TDE_0923 ENOG4105BZ1 (ABC) transporter TDE_0925 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TDE_0928 ENOG4105D5T phosphonate abc transporter TDE_0929 ENOG4105DBV ornithine carbamoyltransferase TDE_0931 ENOG4107QJQ Mate efflux family protein TDE_0932 ENOG4105F8J Adenylate Guanylate cyclase TDE_0933 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TDE_0934 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TDE_0937 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TDE_0938 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TDE_0939 ENOG4105MBR gumn family TDE_0941 ENOG4107TT5 NLP P60 protein TDE_0942 ENOG4105CEY Amp-dependent synthetase and ligase TDE_0947 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TDE_0949 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TDE_0951 ENOG4108SSC basic membrane TDE_0953 ENOG4108TWB ABC transporter (Permease TDE_0954 ENOG4108ZV0 ABC transporter, permease TDE_0955 ENOG4108V0P LemA family TDE_0956 ENOG4105HA9 of methanol dehydrogenase type TDE_0957 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TDE_0958 ENOG4105D78 K07001 NTE family protein TDE_0959 ENOG41085BT Protein of unknown function (DUF1312) TDE_0960 ENOG4105D2T synthase TDE_0961 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TDE_0963 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TDE_0965 ENOG4105D48 metallophosphoesterase TDE_0966 ENOG4105F8V Hydrolase, tatD family TDE_0968 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TDE_0971 ENOG4105C75 arginyL-tRNA synthetase TDE_0972 ENOG4105MJ2 Competence protein TDE_0973 ENOG4105W5Q DNA repair protein (RadC TDE_0977 ENOG4105E6M Sulphatase-modifying factor protein TDE_0979 ENOG4105DZ1 carboxypeptidase TDE_0980 ENOG4105C5S asparaginyl-tRNA synthetase TDE_0984 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component TDE_0985 ENOG4107QSI ABC, transporter TDE_0987 ENOG4108JQ7 (ABC) transporter TDE_0988 ENOG4105DEF Extracellular solute-binding protein, family 5 TDE_0991 ENOG41084P6 50S ribosomal protein l28 TDE_0992 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase TDE_0996 ENOG4107MD5 glycoside hydrolase, family TDE_0997 ENOG4105D82 Glutamate dehydrogenase TDE_0999 ENOG4105TMB Formate nitrite transporter TDE_1000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TDE_1004 ENOG4105I03 Flagellin TDE_1006 ENOG4105CGA flagellar basal-body rod protein FlgG TDE_1007 ENOG4105CGA flagellar basal-body rod protein FlgG TDE_1008 ENOG410680E Flagellar protein TDE_1009 ENOG4105C8Q Methyl-accepting chemotaxis TDE_1010 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TDE_1013 ENOG4105W3S hemerythrin-like, metal-binding protein TDE_1018 ENOG41071ZZ TDE_1019 ENOG4105CG6 trap dicarboxylate transporter dctm subunit TDE_1021 ENOG41081IW Inherit from COG: Membrane TDE_1023 ENOG4107YT1 Glutamate mutase subunit sigma TDE_1025 ENOG41085YX 50S ribosomal protein L32 TDE_1026 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TDE_1027 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) TDE_1029 ENOG4105VN1 Heat shock protein TDE_1033 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate TDE_1034 ENOG4105D7N magnesium and cobalt transport protein CorA TDE_1039 ENOG4105DTN riboflavin biosynthesis protein ribF TDE_1040 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TDE_1041 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TDE_1042 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TDE_1045 ENOG4105WD1 Membrane TDE_1046 ENOG4105VXR cytoplasmic protein TDE_1047 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) TDE_1048 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TDE_1049 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TDE_1054 ENOG41069D7 Methyl-accepting chemotaxis TDE_1055 ENOG4107QJQ Mate efflux family protein TDE_1063 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TDE_1067 ENOG4108JQ7 (ABC) transporter TDE_1068 ENOG4105C3U ABC transporter TDE_1069 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_1074 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_1076 ENOG4108JQ7 (ABC) transporter TDE_1078 ENOG4105CNW domain protein TDE_1079 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN TDE_1080 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TDE_1083 ENOG4105C34 Pseudouridine synthase TDE_1085 ENOG4105DFU Cell wall formation (By similarity) TDE_1086 ENOG4105DSJ YicC domain protein TDE_1087 ENOG4108Z4J Cytidine monophosphate kinase TDE_1088 ENOG4106UUF TDE_1090 ENOG4105C22 threonyL-tRNA synthetase TDE_1093 ENOG4106ARS TDE_1095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TDE_1096 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) TDE_1104 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TDE_1105 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) TDE_1106 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TDE_1107 ENOG4105CHV Transcription elongation factor NusA TDE_1108 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) TDE_1112 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TDE_1118 ENOG4105C0F tryptophanase EC 4.1.99.1 TDE_1122 ENOG4105WN5 stage II sporulation protein TDE_1128 ENOG41090Q2 TDE_1130 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) TDE_1132 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TDE_1162 ENOG4105FA0 parb-like partition protein TDE_1173 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TDE_1175 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TDE_1176 ENOG4105CSA Coproporphyrinogen iii oxidase TDE_1178 ENOG4105E0A ABC, transporter TDE_1179 ENOG4105EHG Permease protein TDE_1183 ENOG4108HWH (ABC) transporter TDE_1188 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TDE_1197 ENOG4107YM1 mraZ protein TDE_1198 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TDE_1200 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TDE_1201 ENOG4105CNI cell division protein FtsW TDE_1203 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TDE_1204 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TDE_1205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TDE_1207 ENOG4105C79 DNA protecting protein DprA TDE_1208 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TDE_1209 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TDE_1210 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) TDE_1211 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) TDE_1212 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TDE_1213 ENOG4108ZC9 flagellar basal-body rod protein flgc TDE_1214 ENOG41069WH flagellar hook-basal body complex TDE_1215 ENOG4107U2N Flagellar M-ring protein TDE_1216 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TDE_1217 ENOG4105W2B Flagellar assembly protein TDE_1218 ENOG4108JIR Flagellum-specific ATP synthase TDE_1223 ENOG4107RBD ABC, transporter TDE_1224 ENOG4107RPQ ABC transporter TDE_1225 ENOG4105DIK (ABC) transporter TDE_1226 ENOG4107SIG periplasmic solute binding protein TDE_1227 ENOG41086CX Inherit from COG: 40-residue yvtn family beta-propeller repeat protein TDE_1229 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TDE_1236 ENOG4105CP7 Triose-phosphate isomerase TDE_1240 ENOG4105C9A Phoh family TDE_1241 ENOG4105CTJ Metal Dependent Phosphohydrolase TDE_1242 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TDE_1243 ENOG4105C37 (CBS) domain TDE_1254 ENOG4105C98 muts2 protein TDE_1257 ENOG41063XV TDE_1259 ENOG4105BZG amino acid carrier protein TDE_1264 ENOG4106B9X TDE_1265 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TDE_1266 ENOG4105CXB phosphoribosylaminoimidazole synthetase TDE_1267 ENOG4105C12 Phosphoribosylglycinamide synthetase TDE_1268 ENOG4108HED Type II restriction TDE_1271 ENOG4108JQ7 (ABC) transporter TDE_1272 ENOG4105C3U ABC transporter TDE_1274 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_1278 ENOG4108UIC UPF0340 protein TDE_1279 ENOG4107QIK phosphoribosylformylglycinamidine synthase TDE_1284 ENOG4105C8Q Methyl-accepting chemotaxis TDE_1285 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TDE_1287 ENOG4108JA2 transcriptioN-repair coupling factor TDE_1292 ENOG4105CMS peptidase U62, modulator of DNA gyrase TDE_1293 ENOG4105D1U peptidase U62 modulator of DNA gyrase TDE_1294 ENOG4105KZ7 phosphocarrier protein hpr TDE_1301 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TDE_1308 ENOG4105CV1 Transketolase (EC 2.2.1.1) TDE_1309 ENOG4105D1U peptidase U62 modulator of DNA gyrase TDE_1311 ENOG4108JJ9 ABC, transporter TDE_1312 ENOG4105D7A ATP-binding protein TDE_1313 ENOG4105C3F Signal peptidase i TDE_1314 ENOG4105CJN penicillin-binding protein TDE_1321 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TDE_1330 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TDE_1332 ENOG4107RIZ hflk protein TDE_1333 ENOG4105EPW hflc protein TDE_1335 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TDE_1338 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) TDE_1339 ENOG4105K4W Could be involved in septation (By similarity) TDE_1340 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) TDE_1341 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TDE_1342 ENOG41069X2 TDE_1343 ENOG4105C0H protease TDE_1345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TDE_1346 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TDE_1349 ENOG4105DFF Rod shape-determining protein mreb TDE_1352 ENOG4105CJN penicillin-binding protein TDE_1353 ENOG4105CNI cell division protein FtsW TDE_1357 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) TDE_1360 ENOG4105C7N Xanthine uracil vitamin C permease TDE_1364 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TDE_1366 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase TDE_1367 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase TDE_1369 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TDE_1370 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) TDE_1375 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TDE_1381 ENOG4108RY1 ATP synthase, subunit E TDE_1384 ENOG4105C59 p-type ATPase TDE_1387 ENOG4105EI2 Pseudouridine synthase TDE_1390 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) TDE_1391 ENOG4105D6A Electron transport complex TDE_1399 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TDE_1400 ENOG4107QMG Nad synthetase TDE_1403 ENOG4105C5H ABC transporter TDE_1404 ENOG4105I76 (LipO)protein TDE_1405 ENOG4108DGI Phosphoribosylformylglycinamidine synthase I TDE_1407 ENOG4105DCI Phosphohydrolase TDE_1410 ENOG4105JTB TDE_1411 ENOG4106FRC TDE_1412 ENOG4107W2M Sodium hydrogen exchanger TDE_1414 ENOG4105DTI Phosphonopyruvate decarboxylase TDE_1415 ENOG4107STF Involved in phosphonate degradation (By similarity) TDE_1417 ENOG4105EY8 ABC transporter TDE_1429 ENOG4105K64 Glycosyl transferase, family 2 TDE_1430 ENOG41088M2 Glycosyl transferase family 2 TDE_1431 ENOG4105CG5 Glycosyl transferase (Group 1 TDE_1433 ENOG4105K64 Glycosyl transferase, family 2 TDE_1435 ENOG4107VDP teichoic acid biosynthesis TDE_1436 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TDE_1438 ENOG4107QPH glycogen) synthase TDE_1439 ENOG4105DMT epimerase dehydratase TDE_1441 ENOG4105C1B dTDP-glucose 4-6-dehydratase TDE_1442 ENOG4105CUT histidyl-tRNA synthetase TDE_1444 ENOG4105CY0 Metallo-Beta-Lactamase TDE_1447 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TDE_1448 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TDE_1449 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TDE_1450 ENOG4105C98 muts2 protein TDE_1454 ENOG4107RBJ symporter TDE_1457 ENOG41090QV Protein of unknown function DUF115 TDE_1458 ENOG4105X4X Protein of unknown function DUF115 TDE_1460 ENOG410698I TDE_1462 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TDE_1463 ENOG4106QD2 TDE_1464 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) TDE_1465 ENOG4105C3F Signal peptidase i TDE_1466 ENOG4105CSA Coproporphyrinogen iii oxidase TDE_1467 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TDE_1469 ENOG4105K8N protein family UPF0079, ATPase TDE_1471 ENOG4106SAP TDE_1472 ENOG4107VE5 flagellar hook-associated protein TDE_1475 ENOG4105I03 Flagellin TDE_1477 ENOG4105I03 Flagellin TDE_1478 ENOG4106RHC TDE_1480 ENOG41068FD TDE_1483 ENOG4106XCQ Inherit from COG: Pfam:DUF82 TDE_1487 ENOG4105CDY transcriptional regulatory protein TDE_1488 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TDE_1491 ENOG4105CBS Chea signal transduction histidine kinase TDE_1492 ENOG4105YFD chemotaxis, protein TDE_1494 ENOG4107Z9R response regulator TDE_1496 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TDE_1498 ENOG4106GEY TDE_1501 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TDE_1503 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TDE_1504 ENOG41082DI 50s ribosomal protein l31 TDE_1506 ENOG4105EJQ L-serine dehydratase TDE_1509 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TDE_1511 ENOG4108SDV Periplasmic Protein TDE_1515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TDE_1516 ENOG4105C19 ABC transporter TDE_1520 ENOG4106DSS Tartrate dehydratase subunit alpha TDE_1521 ENOG4107GFK fumarate TDE_1522 ENOG4105DUA (citrate (pro-3S)-lyase ligase TDE_1523 ENOG4105YGP holo-ACP synthase CitX TDE_1535 ENOG4105D48 metallophosphoesterase TDE_1537 ENOG4105EAH synthase TDE_1538 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TDE_1540 ENOG4105QTX Pfam:UPF0153 TDE_1543 ENOG4105HHA aminodeoxychorismate lyase TDE_1547 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TDE_1548 ENOG4107Z6Q Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TDE_1549 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TDE_1550 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) TDE_1551 ENOG4105DF9 Lipoate-protein, ligase TDE_1575 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) TDE_1576 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TDE_1577 ENOG4106W1H TDE_1580 ENOG410877G TDE_1581 ENOG4105RJI TDE_1582 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) TDE_1587 ENOG4105C9M aspartyl-trna synthetase TDE_1589 ENOG4105YFD chemotaxis, protein TDE_1591 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TDE_1592 ENOG4105C5H ABC transporter TDE_1593 ENOG4107QHI -hydrogenase TDE_1594 ENOG4105BZ8 glutamate synthase TDE_1595 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) TDE_1598 ENOG4108JJB ABC transporter TDE_1599 ENOG4105BZ1 (ABC) transporter TDE_1600 ENOG4105BZ1 (ABC) transporter TDE_1601 ENOG4108IG5 Transcriptional regulator TDE_1603 ENOG4108JJB ABC transporter TDE_1606 ENOG4108IG5 Transcriptional regulator TDE_1608 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TDE_1610 ENOG4105VDM plasmid maintenance system antidote protein, xre family TDE_1612 ENOG4107V28 uracil phosphoribosyltransferase TDE_1616 ENOG4105C5I Dehydrogenase TDE_1624 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TDE_1626 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TDE_1627 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TDE_1631 ENOG4105CHY citrate lyase, alpha TDE_1633 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) TDE_1637 ENOG4105C2M dna polymerase I TDE_1638 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TDE_1640 ENOG4105E2X shikimate dehydrogenase TDE_1641 ENOG4105E66 phosphoriboisomerase A TDE_1642 ENOG4106S0F TDE_1643 ENOG4108120 Pasta domain protein TDE_1644 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TDE_1645 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TDE_1650 ENOG4108JJB ABC transporter TDE_1651 ENOG4105VKD bioY protein TDE_1654 ENOG4105CQ7 ATP-dependent helicase TDE_1656 ENOG4106JWJ TDE_1657 ENOG4105M7K Involved in the transcription termination process (By similarity) TDE_1658 ENOG4107Z25 Basic membrane protein TDE_1659 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TDE_1662 ENOG4105CDU Replicative dna helicase TDE_1667 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TDE_1669 ENOG4105C87 Aminotransferase class I and II TDE_1671 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TDE_1672 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TDE_1673 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TDE_1675 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TDE_1676 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TDE_1677 ENOG4105Z8H single-stranded DNA-binding protein TDE_1678 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) TDE_1681 ENOG4108WBK V-type ATP synthase subunit D TDE_1682 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit TDE_1683 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) TDE_1684 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TDE_1686 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TDE_1687 ENOG4108QUE repeat-containing protein TDE_1689 ENOG4105CJ1 ABC, transporter TDE_1697 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TDE_1708 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) TDE_1709 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) TDE_1710 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) TDE_1712 ENOG4107NGC Flagellar filament outer layer protein TDE_1714 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TDE_1715 ENOG4105BZA Phosphoglycerate kinase TDE_1718 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TDE_1719 ENOG4105K56 Transcriptional regulator TDE_1725 ENOG41090QR TDE_1726 ENOG4105DJ0 Poly(A) Polymerase TDE_1730 ENOG4105CNT hydrolase family 2 TDE_1732 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TDE_1733 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TDE_1734 ENOG4105CGK Exodeoxyribonuclease III TDE_1736 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding TDE_1738 ENOG4105DR5 peptidase TDE_1741 ENOG4108JQC penicillin-binding protein 1A TDE_1744 ENOG4105CAH Chromate TDE_1745 ENOG4107ZFZ Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) TDE_1747 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TDE_1748 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TDE_1749 ENOG4105K46 50S ribosomal protein l27 TDE_1751 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) TDE_1753 ENOG4105CMR udp-glucose 4-epimerase TDE_1754 ENOG4105MAX Superoxide reductase TDE_1763 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TDE_1784 ENOG41086D8 Transcriptional regulator TDE_1851 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TDE_1852 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TDE_1863 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TDE_1864 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TDE_1877 ENOG410852B Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TDE_1880 ENOG4106YRG TDE_1886 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TDE_1893 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TDE_1894 ENOG4108R3D Electron transport complex TDE_1895 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) TDE_1896 ENOG4105DC1 bifunctional purine biosynthesis protein purh TDE_1897 ENOG4108V3E phosphoribosylglycinamide formyltransferase TDE_1898 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TDE_1900 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TDE_1907 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TDE_1910 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TDE_1912 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TDE_1913 ENOG4105DR4 Methyltransferase TDE_1914 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TDE_1915 ENOG4107QW4 alcohol dehydrogenase TDE_1916 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TDE_1917 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) TDE_1919 ENOG4108ZVA radical SAM domain protein TDE_1920 ENOG4106XJW TDE_1925 ENOG4108YZY peptidylprolyl cis-trans isomerase TDE_1927 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) TDE_1931 ENOG4105KG3 cytidine deaminase TDE_1943 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TDE_1948 ENOG4105UIB (ABC) transporter TDE_1949 ENOG4108JQ9 ABC transporter TDE_1950 ENOG4107TFB basic membrane TDE_1951 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) TDE_1963 ENOG4105EM7 Selenocysteine-specific translation elongation factor TDE_1965 ENOG4107RWR Sodium hydrogen exchanger TDE_1966 ENOG4105C0H protease TDE_1968 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) TDE_1969 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TDE_1970 ENOG4105BZU Histidine kinase TDE_1971 ENOG4105FA2 dna polymerase iii TDE_1973 ENOG4107JR8 Colicin v production protein TDE_1974 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TDE_1985 ENOG4105J3I TDE_1987 ENOG4106AG2 TDE_1988 ENOG4105MB2 TDE_1990 ENOG4105DVT helicase TDE_1993 ENOG4108IJ0 Aspartate ammonia-lyase TDE_1995 ENOG4105C0P Mg chelatase subunit ChlI TDE_1999 ENOG4108JDX DNA polymerase iii, epsilon subunit TDE_2001 ENOG4105DPN Oligoendopeptidase f TDE_2005 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) TDE_2009 ENOG4108M1M outer membrane lipoprotein-sorting protein TDE_2029 ENOG4105F8V Hydrolase, tatD family TDE_2030 ENOG4105K6T rare lipoprotein A TDE_2034 ENOG4105BZF Glycosyl transferase (Group 1 TDE_2035 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TDE_2036 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TDE_2037 ENOG41066A3 ATP guanido phosphotransferase TDE_2038 ENOG4108Z0C Uvrb UvrC protein TDE_2040 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TDE_2041 ENOG4105D60 lipoprotein releasing system transmembrane protein TDE_2043 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TDE_2044 ENOG4106MPK TDE_2048 ENOG4105G9E TDE_2049 ENOG4108J59 Extracellular solute-binding protein, family 5 TDE_2052 ENOG4105C9B Cysteine desulfurase TDE_2063 ENOG4105CE1 Ferrous iron transport protein b TDE_2064 ENOG4107K9B ferrous iron transport protein TDE_2066 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TDE_2069 ENOG4105KME endoribonuclease L-psp TDE_2072 ENOG4105ZFX TDE_2074 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TDE_2075 ENOG4105BZU Histidine kinase TDE_2078 ENOG4105W0I repeat-containing protein TDE_2079 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TDE_2080 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TDE_2084 ENOG4105CVS RNA methyltransferase TrmH family, group 1 TDE_2085 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TDE_2086 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TDE_2087 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) TDE_2088 ENOG4105SCY DNAK suppressor TDE_2090 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TDE_2096 ENOG4105EHZ conserved protein UCP016719 TDE_2107 ENOG4105CD3 dihydroorotase TDE_2109 ENOG4105C1J atp-dependent rna helicase TDE_2110 ENOG4105SKN orotidine 5''-phosphate decarboxylase TDE_2114 ENOG4105DA5 (ABC) transporter TDE_2116 ENOG4106NKH TDE_2117 ENOG4106J2Q Uncharacterised protein family (UPF0164) TDE_2118 ENOG4105DF5 DNA topoisomerase IV, subunit A TDE_2120 ENOG4105EZ5 reductase TDE_2121 ENOG4105WPN DNA integration recombination invertion protein TDE_2123 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) TDE_2131 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) TDE_2132 ENOG4108JJB ABC transporter TDE_2140 ENOG4105CUG Oligopeptidase b TDE_2142 ENOG4105C8Q Methyl-accepting chemotaxis TDE_2143 ENOG4108JQB penicillin-binding protein 1C TDE_2144 ENOG4105CEM UPF0597 protein TDE_2149 ENOG4105E9H Lytic Murein transglycosylase TDE_2151 ENOG41082MQ UPF0178 protein TDE_2152 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) TDE_2153 ENOG4106BH8 TDE_2154 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TDE_2155 ENOG41084MZ 50S ribosomal protein L35 TDE_2156 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TDE_2158 ENOG4108JJB ABC transporter TDE_2161 ENOG4105D9U N-acetyltransferase TDE_2162 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TDE_2165 ENOG4107RSS Hydrogenase accessory protein HypB TDE_2171 ENOG4108I0C methyltransferase TDE_2176 ENOG4108SVB resolvase TDE_2180 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TDE_2181 ENOG410841Q phosphoesterase PA-phosphatase related protein TDE_2183 ENOG41062Z1 TDE_2186 ENOG4108IQE Amp-dependent synthetase and ligase TDE_2189 ENOG4105DR5 peptidase TDE_2190 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TDE_2192 ENOG4105D98 threonine synthase TDE_2194 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TDE_2195 ENOG4105C34 Pseudouridine synthase TDE_2198 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TDE_2199 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TDE_2200 ENOG4105C28 cystathionine TDE_2208 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 TDE_2212 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TDE_2215 ENOG4107R2W ABC transporter, permease TDE_2216 ENOG4105C2J ABC transporter TDE_2217 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator TDE_2219 ENOG4105C3F Signal peptidase i TDE_2220 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TDE_2221 ENOG4106KG8 TDE_2226 ENOG4105DSE periplasmic solute binding protein TDE_2228 ENOG4105CIN aminoacyl-histidine dipeptidase TDE_2232 ENOG4105E0A ABC, transporter TDE_2233 ENOG4105EHG Permease protein TDE_2234 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TDE_2236 ENOG4105DJI Methylaspartate mutase, E subunit TDE_2243 ENOG4106N3A copper homeostasis protein cutc TDE_2245 ENOG4105DNX Dna topoisomerase iv (Subunit b) TDE_2248 ENOG4105CUZ uba thif-type nad fad binding protein TDE_2249 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TDE_2257 ENOG4105CGH 5'-nucleotidase TDE_2262 ENOG4105CFP Peptidase U32 TDE_2264 ENOG4105BZ1 (ABC) transporter TDE_2270 ENOG4105C8Q Methyl-accepting chemotaxis TDE_2271 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TDE_2274 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) TDE_2275 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TDE_2277 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TDE_2279 ENOG4108HU6 Metal dependent phosphohydrolase TDE_2282 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) TDE_2283 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TDE_2286 ENOG4105DXN mazG family TDE_2287 ENOG4108V1T peptidylprolyl cis-trans isomerase TDE_2289 ENOG4105C22 threonyL-tRNA synthetase TDE_2290 ENOG4108VJ1 Transcriptional regulator (CarD family TDE_2291 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TDE_2292 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TDE_2295 ENOG4105D8X mechanosensitive ion channel TDE_2298 ENOG41080VC Galactokinase (EC 2.7.1.6) TDE_2299 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) TDE_2300 ENOG4105C0H protease TDE_2302 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TDE_2303 ENOG41082I4 UPF0102 protein TDE_2307 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TDE_2309 ENOG4108JUA Transcriptional regulator TDE_2315 ENOG4105DFA alanine racemase domain protein TDE_2317 ENOG4108UT2 hemolysin iii TDE_2318 ENOG4105E4C Lytic transglycosylase catalytic TDE_2323 ENOG4105CUY Mechanosensitive ion channel TDE_2324 ENOG4105WH1 Two component transcriptional regulator luxr family TDE_2327 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TDE_2328 ENOG4105CFC Transporter TDE_2333 ENOG4108UB4 uncharacterized protein ygjQ TDE_2335 ENOG4105C4R Atp-dependent dna helicase TDE_2336 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) TDE_2339 ENOG4105C8T Leucyl-tRNA synthetase TDE_2341 ENOG4105DZP Membrane-associated zinc metalloprotease TDE_2342 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TDE_2343 ENOG4105KNE Phosphatidate cytidylyltransferase TDE_2344 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TDE_2345 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) TDE_2346 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TDE_2347 ENOG4105CE9 30S ribosomal protein S2 TDE_2348 ENOG4108Z03 MAF-like protein TDE_2349 ENOG4105SXG TDE_2350 ENOG4105ZF0 Lipoprotein TDE_2351 ENOG41069DF TDE_2353 ENOG4105I03 Flagellin TDE_2354 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) TDE_2355 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) TDE_2357 ENOG4108U1V ABC transporter, permease TDE_2359 ENOG4105CMT Dihydroxyacetone kinase TDE_2360 ENOG4105CMT Dihydroxyacetone kinase TDE_2363 ENOG4108IV0 ABC, transporter TDE_2364 ENOG4105C0Z ABC transporter TDE_2365 ENOG4105CF8 branched-chain amino acid ABC transporter, permease TDE_2366 ENOG4105C32 Amino acid ABC transporter (Permease) TDE_2368 ENOG4108UIN ybak prolyl-trna synthetase associated region TDE_2369 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TDE_2371 ENOG4105HEE Binding Domain protein TDE_2372 ENOG4107ZT5 Thiol disulfide interchange protein TDE_2373 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase TDE_2374 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase TDE_2376 ENOG41089XN TDE_2378 ENOG4105CJ1 ABC, transporter TDE_2381 ENOG4105BZU Histidine kinase TDE_2383 ENOG4107ZET Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) TDE_2385 ENOG4105CPF Cell wall formation (By similarity) TDE_2387 ENOG4108IUJ 4-alpha-glucanotransferase TDE_2388 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TDE_2389 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) TDE_2391 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) TDE_2395 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein TDE_2396 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TDE_2398 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) TDE_2400 ENOG4105VG0 50S ribosomal protein l34 TDE_2401 ENOG4105EXW epimerase dehydratase TDE_2403 ENOG4105C5X domain protein TDE_2407 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase TDE_2410 ENOG4105C87 Aminotransferase class I and II TDE_2420 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TDE_2421 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TDE_2422 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TDE_2423 ENOG4108VZM 50s ribosomal protein L10 TDE_2424 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) TDE_2425 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TDE_2426 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TDE_2428 ENOG41084ED 50S ribosomal protein L33 TDE_2435 ENOG4105Z8J TDE_2438 ENOG4107SVH Potassium channel protein TDE_2439 ENOG4105DER m42 family TDE_2440 ENOG4108JJA ABC, transporter TDE_2446 ENOG4105C6K Malic enzyme TDE_2449 ENOG4105NBF ammecr1 domain protein TDE_2450 ENOG41082BE ankyrin repeat-containing protein TDE_2451 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) TDE_2460 ENOG4105C9B Cysteine desulfurase TDE_2466 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) TDE_2470 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TDE_2473 ENOG41084YP 30S ribosomal protein S21 TDE_2475 ENOG4107QI1 Mate efflux family protein TDE_2476 ENOG4105C5B carbamate kinase TDE_2477 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) TDE_2478 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TDE_2480 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) TDE_2489 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TDE_2490 ENOG4105C25 Primosomal protein n' TDE_2491 ENOG4108UN4 phage SPO1 DNA polymerase-related protein TDE_2492 ENOG41061XC TDE_2496 ENOG4105C8Q Methyl-accepting chemotaxis TDE_2499 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TDE_2502 ENOG4105BZU Histidine kinase TDE_2504 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TDE_2510 ENOG4105BZ1 (ABC) transporter TDE_2511 ENOG4105BZ1 (ABC) transporter TDE_2512 ENOG4105C26 Dehydrogenase TDE_2513 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TDE_2515 ENOG4105E6M Sulphatase-modifying factor protein TDE_2517 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TDE_2522 ENOG4105BZ1 (ABC) transporter TDE_2525 ENOG4106SUR Protein of unknown function DUF115 TDE_2526 ENOG4108W50 ppic-type peptidyL-prolyl cis-trans isomerase TDE_2527 ENOG4105HA9 of methanol dehydrogenase type TDE_2534 ENOG4105CSM endonuclease III TDE_2545 ENOG4106TEA TDE_2546 ENOG4108JYZ YitT family TDE_2549 ENOG4105C8Q Methyl-accepting chemotaxis TDE_2552 ENOG4105BZ1 (ABC) transporter TDE_2553 ENOG4105DK7 lysyl-tRNA synthetase TDE_2554 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) TDE_2555 ENOG41081F0 Precorrin-8x methylmutase TDE_2558 ENOG4105BZ1 (ABC) transporter TDE_2559 ENOG4108JJ9 ABC, transporter TDE_2561 ENOG4105FDK ABC transporter TDE_2562 ENOG4105FAV ABC, transporter TDE_2568 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) TDE_2569 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TDE_2570 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TDE_2571 ENOG4105VEM Conserved domain protein TDE_2572 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase TDE_2573 ENOG4107QP8 phosphohexose isomerase TDE_2574 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) TDE_2576 ENOG4105C34 Pseudouridine synthase TDE_2579 ENOG4105CB5 ATP-dependent DNA helicase recG TDE_2580 ENOG4105BZU Histidine kinase TDE_2582 ENOG4105BZU Histidine kinase TDE_2584 ENOG4105DZW Dipeptidase TDE_2585 ENOG4108W2P Methyl-accepting chemotaxis TDE_2586 ENOG4105C6E dna polymerase iii TDE_2589 ENOG4105DFM M18 family aminopeptidase TDE_2591 ENOG4105C72 UPF0176 protein TDE_2592 ENOG41062BZ domain protein TDE_2597 ENOG4105DJV ribulose-phosphate 3-epimerase TDE_2599 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TDE_2601 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane TDE_2603 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) TDE_2605 ENOG4105CVJ phosphoglycerate mutase TDE_2606 ENOG4105CGP Urocanate hydratase TDE_2609 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TDE_2614 ENOG4105CJ2 (LipO)protein TDE_2615 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TDE_2616 ENOG4105IJJ transcriptional regulator, crp fnr family TDE_2619 ENOG4107SCN K03215 23S rRNA (uracil1939-C5)-methyltransferase EC 2.1.1.190 TDE_2622 ENOG4108JJB ABC transporter TDE_2625 ENOG4105BZ1 (ABC) transporter TDE_2629 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TDE_2631 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TDE_2639 ENOG4105DPN Oligoendopeptidase f TDE_2646 ENOG4108IJ7 Glycine betaine TDE_2647 ENOG4105DF9 Lipoate-protein, ligase TDE_2650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TDE_2651 ENOG4108JJB ABC transporter TDE_2656 ENOG4107PPM cobalt chelatase TDE_2657 ENOG4105DVK Precorrin-2 c20-methyltransferase TDE_2658 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) TDE_2659 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TDE_2663 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TDE_2665 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TDE_2668 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TDE_2669 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase TDE_2670 ENOG4105ESV Glycosyl transferase, family 4 TDE_2676 ENOG4105D98 threonine synthase TDE_2683 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TDE_2686 ENOG4105FZW flagellar biosynthesis regulator FlhF TDE_2687 ENOG4105CIH Imidazole acetol-phosphate transaminase TDE_2692 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TDE_2713 ENOG4105EIB trna rrna methyltransferase TDE_2716 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TDE_2718 ENOG4105CJW magnesium transporter TDE_2720 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TDE_2723 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TDE_2725 ENOG4105BZU Histidine kinase TDE_2726 ENOG4105BZU Histidine kinase TDE_2730 ENOG4105F8V Hydrolase, tatD family TDE_2731 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TDE_2746 ENOG4105CVR type I restriction-modification system TDE_2747 ENOG4108F3G Type I restriction-modification system, R subunit TDE_2750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TDE_2752 ENOG41063VX Inherit from COG: glutaredoxin-related protein TDE_2753 ENOG4105DR5 peptidase TDE_2754 ENOG4107QWB Ornithine cyclodeaminase TDE_2756 ENOG4108J59 Extracellular solute-binding protein, family 5 TDE_2758 ENOG4105VXP Protein of unknown function DUF86 TDE_2760 ENOG4105CN7 Flagellar biosynthetic protein FliP TDE_2762 ENOG4105DD5 Flagellar motor switch protein TDE_2763 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TDE_2764 ENOG41064SM flagellar basal body-associated protein flil TDE_2765 ENOG4107XSU flagellar motor protein motb TDE_2766 ENOG4107R0U MotA TolQ exbB proton channel TDE_2768 ENOG4105BZE flagellar hook protein, FlgE TDE_2769 ENOG410822I Flagellar hook capping protein TDE_2772 ENOG4105BZ1 (ABC) transporter TDE_2781 ENOG4105BZ1 (ABC) transporter TDE_2782 ENOG4105BZ1 (ABC) transporter TDE_2783 ENOG4105C8Q Methyl-accepting chemotaxis TDE_2784 ENOG41090KZ TDE_2786 ENOG4105C0B DNA polymerase III (alpha subunit)