locus-tag	class	description
E4N90_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N90_00015	COG0587	DNA-directed DNA polymerase activity
E4N90_00040	COG0840	transmembrane signaling receptor activity
E4N90_00045	COG1132	(ABC) transporter
E4N90_00050	COG1132	(ABC) transporter
E4N90_00095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N90_00110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N90_00115	COG1360	Flagellar Motor Protein
E4N90_00120	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N90_00125	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N90_00130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N90_00130	COG1776	CheC inhibitor of MCP methylation
E4N90_00140	COG1338	Plays a role in the flagellum-specific transport system
E4N90_00150	COG2361	Protein of unknown function DUF86
E4N90_00160	COG4166	transmembrane transport
E4N90_00165	COG2423	ornithine cyclodeaminase activity
E4N90_00170	COG0739	heme binding
E4N90_00175	COG4545	Glutaredoxin-related protein
E4N90_00190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N90_00215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N90_00225	COG0732	type I restriction modification DNA specificity domain
E4N90_00230	COG0732	type I restriction modification DNA specificity domain
E4N90_00235	COG4974	Belongs to the 'phage' integrase family
E4N90_00280	COG3116	cell division
E4N90_00280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N90_00285	COG0084	hydrolase, TatD family'
E4N90_00295	COG1373	ATPase (AAA superfamily
E4N90_00300	COG2199	diguanylate cyclase activity
E4N90_00300	COG2203	Gaf domain
E4N90_00310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N90_00325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N90_00335	COG2239	Acts as a magnesium transporter
E4N90_00345	COG0546	phosphoglycolate phosphatase activity
E4N90_00360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N90_00395	COG2211	Major facilitator Superfamily
E4N90_00425	COG1747	RNA polymerase binding
E4N90_00425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N90_00440	COG0504	CTP synthase activity
E4N90_00450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N90_00455	COG1419	protein localization to endoplasmic reticulum
E4N90_00470	COG1191	sigma factor activity
E4N90_00505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N90_00535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N90_00540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N90_00545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N90_00555	COG0516	GMP reductase activity
E4N90_00560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N90_00580	COG3437	response regulator, receiver
E4N90_00580	COG0784	Response regulator, receiver
E4N90_00585	COG1797	cobyrinic acid a,c-diamide synthase activity
E4N90_00615	COG1122	ATPase activity
E4N90_00620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N90_00625	COG1131	(ABC) transporter
E4N90_00635	COG1132	(ABC) transporter
E4N90_00640	COG0095	Lipoate-protein ligase
E4N90_00645	COG0517	IMP dehydrogenase activity
E4N90_00645	COG4175	Glycine betaine
E4N90_00655	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N90_00660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4N90_00660	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4N90_00670	COG3177	Filamentation induced by cAMP protein fic
E4N90_00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_00725	COG0747	negative chemotaxis
E4N90_00735	COG1132	(ABC) transporter
E4N90_00735	COG2375	cellular response to nickel ion
E4N90_00755	COG1129	ABC transporter
E4N90_00795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N90_00810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N90_00815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N90_00820	COG1477	protein flavinylation
E4N90_00840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N90_00855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N90_00860	COG0406	alpha-ribazole phosphatase activity
E4N90_00865	COG3314	Sporulation integral membrane protein YlbJ
E4N90_00880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N90_00890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N90_00900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N90_00910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N90_00935	COG0724	RNA recognition motif
E4N90_00940	COG1054	Belongs to the UPF0176 family
E4N90_00945	COG1362	aminopeptidase activity
E4N90_00960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N90_00965	COG0840	transmembrane signaling receptor activity
E4N90_00965	COG3290	protein histidine kinase activity
E4N90_00990	COG3706	GGDEF domain
E4N90_00995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N90_01010	COG0564	pseudouridine synthase activity
E4N90_01020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N90_01025	COG0166	Belongs to the GPI family
E4N90_01030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N90_01035	COG4443	Transcriptional Coactivator p15 (PC4)
E4N90_01040	COG0328	RNA-DNA hybrid ribonuclease activity
E4N90_01045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N90_01050	COG0301	tRNA thio-modification
E4N90_01080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N90_01085	COG1121	(ABC) transporter
E4N90_01090	COG4988	ABC transporter
E4N90_01095	COG1132	(ABC) transporter
E4N90_01110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N90_01115	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N90_01120	COG1132	(ABC) transporter
E4N90_01145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N90_01195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N90_01230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N90_01245	COG2604	Protein of unknown function DUF115
E4N90_01260	COG1132	(ABC) transporter
E4N90_01270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N90_01280	COG4115	mRNA cleavage
E4N90_01315	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N90_01320	COG1012	belongs to the aldehyde dehydrogenase family
E4N90_01325	COG1132	(ABC) transporter
E4N90_01330	COG1132	(ABC) transporter
E4N90_01355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N90_01390	COG0840	transmembrane signaling receptor activity
E4N90_01405	COG1573	uracil-dna glycosylase
E4N90_01410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N90_01445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N90_01450	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N90_01485	COG0326	Molecular chaperone. Has ATPase activity
E4N90_01495	COG0322	excinuclease ABC activity
E4N90_01500	COG1921	L-seryl-tRNASec selenium transferase activity
E4N90_01515	COG0549	Belongs to the carbamate kinase family
E4N90_01520	COG0534	Mate efflux family protein
E4N90_01530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N90_01540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N90_01545	COG0765	amino acid transport
E4N90_01555	COG1126	abc transporter atp-binding protein
E4N90_01560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N90_01575	COG0425	Belongs to the sulfur carrier protein TusA family
E4N90_01595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N90_01635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N90_01640	COG0666	response to abiotic stimulus
E4N90_01645	COG2078	PFAM AMMECR1 domain protein
E4N90_01645	COG3885	ferrous iron binding
E4N90_01660	COG0281	malic enzyme
E4N90_01665	COG1363	Peptidase, m42
E4N90_01670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4N90_01730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N90_01740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N90_01745	COG0250	Participates in transcription elongation, termination and antitermination
E4N90_01750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N90_01755	COG0081	regulation of translation
E4N90_01760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N90_01765	COG0222	ribosome binding
E4N90_01770	COG0085	RNA polymerase activity
E4N90_01775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N90_01780	COG0601	transmembrane transport
E4N90_01785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_01790	COG4172	Belongs to the ABC transporter superfamily
E4N90_01835	COG0058	SHG alpha-glucan phosphorylase activity
E4N90_01840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N90_01855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N90_01875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N90_01885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N90_01890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N90_01895	COG0594	ribonuclease P activity
E4N90_01900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N90_01905	COG0706	membrane insertase activity
E4N90_01910	COG1847	R3H domain protein
E4N90_01920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N90_01930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4N90_01935	COG0740	serine-type endopeptidase activity
E4N90_01940	COG1640	4-alpha-glucanotransferase
E4N90_01950	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N90_01960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N90_01970	COG4585	Histidine kinase
E4N90_01985	COG1131	(ABC) transporter
E4N90_01990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N90_02010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N90_02025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N90_02030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N90_02070	COG2376	Dihydroxyacetone kinase
E4N90_02085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N90_02095	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N90_02100	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N90_02125	COG1413	lyase activity
E4N90_02130	COG0424	maF-like protein
E4N90_02135	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N90_02140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N90_02145	COG0233	cytoplasmic translational termination
E4N90_02150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N90_02155	COG0575	Belongs to the CDS family
E4N90_02160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N90_02165	COG0750	zinc metalloprotease
E4N90_02175	COG0495	leucyl-tRNA aminoacylation
E4N90_02190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N90_02195	COG0210	DNA helicase
E4N90_02205	COG2949	membrane
E4N90_02210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N90_02215	COG0542	response to heat
E4N90_02230	COG2197	response regulator
E4N90_02235	COG0668	transmembrane transport
E4N90_02260	COG1196	nuclear chromosome segregation
E4N90_02260	COG0741	lytic transglycosylase activity
E4N90_02260	COG0739	heme binding
E4N90_02265	COG1272	protein, Hemolysin III
E4N90_02280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N90_02525	COG3604	Transcriptional regulator
E4N90_02545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N90_02560	COG0792	nuclease activity
E4N90_02575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N90_02580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N90_02585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N90_02605	COG0668	transmembrane transport
E4N90_02620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N90_02625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N90_02625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N90_02630	COG1329	Transcriptional regulator
E4N90_02635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N90_02645	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N90_02650	COG3956	TIGRFAM MazG family protein
E4N90_02670	COG1136	(ABC) transporter
E4N90_02670	COG0577	efflux transmembrane transporter activity
E4N90_02675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N90_02690	COG1639	'signal transduction protein
E4N90_02695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N90_02705	COG0101	tRNA pseudouridine synthase activity
E4N90_02720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N90_02725	COG0840	transmembrane signaling receptor activity
E4N90_02730	COG1132	(ABC) transporter
E4N90_02740	COG0826	peptidase U32
E4N90_02745	COG0737	Belongs to the 5'-nucleotidase family
E4N90_02785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N90_02810	COG3142	Participates in the control of copper homeostasis
E4N90_02830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N90_02835	COG4865	methylaspartate mutase activity
E4N90_02850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N90_02855	COG1120	ATPase activity
E4N90_02875	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N90_02885	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N90_02905	COG0442	prolyl-tRNA aminoacylation
E4N90_02920	COG1879	ABC-type sugar transport system periplasmic component
E4N90_02925	COG1129	ABC transporter
E4N90_02930	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N90_02945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N90_02965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N90_02985	COG2056	Na+-H+ antiporter family
E4N90_02990	COG1757	Na H antiporter
E4N90_03000	COG0626	cystathionine gamma-synthase activity
E4N90_03005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N90_03010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N90_03010	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N90_03010	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N90_03010	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N90_03015	COG0564	pseudouridine synthase activity
E4N90_03020	COG0156	8-amino-7-oxononanoate synthase activity
E4N90_03030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N90_03040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N90_03040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N90_03045	COG0739	heme binding
E4N90_03055	COG1475	DNA binding
E4N90_03060	COG1022	Amp-dependent synthetase and ligase
E4N90_03085	COG0671	phosphoesterase, PA-phosphatase related
E4N90_03090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N90_03125	COG2226	methyltransferase
E4N90_03135	COG1028	Short-chain dehydrogenase reductase Sdr
E4N90_03185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N90_03195	COG2738	Putative neutral zinc metallopeptidase
E4N90_03200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4N90_03200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4N90_03205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N90_03215	COG1129	ABC transporter
E4N90_03230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N90_03235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N90_03245	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N90_03250	COG1671	Belongs to the UPF0178 family
E4N90_03260	COG0741	lytic transglycosylase activity
E4N90_03260	COG1388	LysM domain
E4N90_03285	COG3681	Belongs to the UPF0597 family
E4N90_03290	COG4953	penicillin-binding protein 1C
E4N90_03295	COG1770	oligopeptidase
E4N90_03325	COG1122	ATPase activity
E4N90_03365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N90_03410	COG1131	(ABC) transporter
E4N90_03430	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N90_03435	COG0513	Belongs to the DEAD box helicase family
E4N90_03445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N90_03470	COG3876	Protein conserved in bacteria
E4N90_03475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N90_03495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N90_03500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N90_03505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N90_03510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N90_03515	COG0484	heat shock protein binding
E4N90_03520	COG0528	UMP kinase activity
E4N90_03525	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N90_03540	COG0539	negative regulation of cytoplasmic translation
E4N90_03545	COG2204	response regulator
E4N90_03550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N90_03565	COG5001	Diguanylate cyclase
E4N90_03570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N90_03595	COG0251	oxidation-reduction process
E4N90_03605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N90_03610	COG1722	exodeoxyribonuclease VII activity
E4N90_03620	COG1918	ferrous iron import across plasma membrane
E4N90_03625	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4N90_03625	COG1918	ferrous iron import across plasma membrane
E4N90_03670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N90_03705	COG3561	AntA/AntB antirepressor
E4N90_03745	COG0629	single-stranded DNA binding
E4N90_03750	COG1192	Involved in chromosome partitioning
E4N90_03755	COG1475	DNA binding
E4N90_03775	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4N90_03880	COG0740	serine-type endopeptidase activity
E4N90_03925	COG3657	addiction module killer protein
E4N90_04020	COG4166	transmembrane transport
E4N90_04035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N90_04050	COG0552	protein localization to endoplasmic reticulum
E4N90_04060	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N90_04065	COG1136	(ABC) transporter
E4N90_04075	COG3880	PFAM UvrB UvrC protein
E4N90_04080	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N90_04090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N90_04095	COG0438	transferase activity, transferring glycosyl groups
E4N90_04105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N90_04115	COG0084	hydrolase, TatD family'
E4N90_04120	COG2885	chlorophyll binding
E4N90_04245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N90_04255	COG2375	cellular response to nickel ion
E4N90_04255	COG1132	(ABC) transporter
E4N90_04265	COG1309	transcriptional regulator
E4N90_04280	COG1164	Oligoendopeptidase f
E4N90_04290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N90_04295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N90_04300	COG0606	chelatase, subunit chli
E4N90_04310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4N90_04310	COG2885	chlorophyll binding
E4N90_04320	COG1199	ATP-dependent helicase activity
E4N90_04330	COG0823	Involved in the tonB-independent uptake of proteins
E4N90_04345	COG4254	PFAM FecR protein
E4N90_04375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N90_04380	COG1286	toxin biosynthetic process
E4N90_04385	COG0470	DNA polymerase III
E4N90_04390	COG3852	Histidine kinase
E4N90_04395	COG2204	response regulator
E4N90_04400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N90_04410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N90_04415	COG0475	glutathione-regulated potassium exporter activity
E4N90_04420	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N90_04475	COG0456	acetyltransferase
E4N90_04480	COG1234	tRNA 3'-trailer cleavage
E4N90_04485	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N90_04490	COG3845	ABC transporter
E4N90_04495	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N90_04500	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N90_04530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N90_04645	COG1047	Peptidyl-prolyl cis-trans
E4N90_04670	COG0731	radical SAM domain protein
E4N90_04680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N90_04685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N90_04690	COG1979	alcohol dehydrogenase
E4N90_04695	COG2255	four-way junction helicase activity
E4N90_04705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N90_04710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N90_04725	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N90_04735	COG0653	protein targeting
E4N90_04740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N90_04745	COG0138	bifunctional purine biosynthesis protein purh
E4N90_04750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N90_04755	COG2878	Part of a membrane complex involved in electron transport
E4N90_04760	COG0481	GTPase activity
E4N90_04770	COG1114	Component of the transport system for branched-chain amino acids
E4N90_04785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N90_04815	COG0488	(ABC) transporter
E4N90_04825	COG0793	Belongs to the peptidase S41A family
E4N90_04870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N90_04875	COG0632	four-way junction helicase activity
E4N90_04930	COG1136	(ABC) transporter
E4N90_05070	COG0539	negative regulation of cytoplasmic translation
E4N90_05140	COG1418	mRNA catabolic process
E4N90_05155	COG2033	superoxide reductase activity
E4N90_05160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N90_05165	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N90_05175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N90_05180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N90_05195	COG0799	negative regulation of ribosome biogenesis
E4N90_05200	COG2059	Chromate
E4N90_05235	COG0739	heme binding
E4N90_05245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N90_05255	COG0708	Exodeoxyribonuclease III
E4N90_05260	COG0024	Methionine aminopeptidase
E4N90_05265	COG0484	heat shock protein binding
E4N90_05295	COG0617	tRNA 3'-terminal CCA addition
E4N90_05330	COG1846	Transcriptional regulator
E4N90_05335	COG0519	Catalyzes the synthesis of GMP from XMP
E4N90_05350	COG0126	phosphoglycerate kinase activity
E4N90_05355	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N90_05375	COG0268	Binds directly to 16S ribosomal RNA
E4N90_05380	COG0776	regulation of translation
E4N90_05385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N90_05395	COG1058	Belongs to the CinA family
E4N90_05395	COG1546	Belongs to the CinA family
E4N90_05430	COG0588	phosphoglycerate mutase activity
E4N90_05460	COG1131	(ABC) transporter
E4N90_05470	COG0457	Tetratricopeptide repeat
E4N90_05475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N90_05480	COG4251	negative regulation of phosphorylation
E4N90_05480	COG2203	Gaf domain
E4N90_05480	COG3706	GGDEF domain
E4N90_05480	COG5001	Diguanylate cyclase
E4N90_05485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N90_05490	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N90_05495	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N90_05500	COG1394	ATPase activity, coupled to movement of substances
E4N90_05505	COG1269	ATP hydrolysis coupled proton transport
E4N90_05515	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N90_05520	COG0629	single-stranded DNA binding
E4N90_05525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N90_05530	COG0359	binds to the 23S rRNA
E4N90_05540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N90_05545	COG0740	serine-type endopeptidase activity
E4N90_05550	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N90_05570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N90_05580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N90_05600	COG0305	Participates in initiation and elongation during chromosome replication
E4N90_05615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N90_05620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N90_05625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N90_05645	COG1132	(ABC) transporter
E4N90_05650	COG1132	(ABC) transporter
E4N90_05655	COG1268	BioY protein
E4N90_05660	COG1122	ATPase activity
E4N90_05685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N90_05700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N90_05705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N90_05715	COG0237	dephospho-CoA kinase activity
E4N90_05720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N90_05720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N90_05720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N90_05740	COG3052	prosthetic group binding
E4N90_05770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N90_05780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N90_05785	COG0509	glycine decarboxylation via glycine cleavage system
E4N90_05790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N90_05795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N90_05800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N90_05820	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N90_05865	COG1129	ABC transporter
E4N90_05870	COG1309	transcriptional regulator
E4N90_05875	COG2375	cellular response to nickel ion
E4N90_05875	COG1132	(ABC) transporter
E4N90_05880	COG1132	(ABC) transporter
E4N90_05885	COG1129	ABC transporter
E4N90_05900	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N90_05905	COG0493	'glutamate synthase
E4N90_05905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N90_05915	COG0488	(ABC) transporter
E4N90_05920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N90_05930	COG0835	chemotaxis
E4N90_05945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N90_05950	COG0531	amino acid
E4N90_05960	COG0297	glycogen (starch) synthase activity
E4N90_05965	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N90_05970	COG2982	Protein involved in outer membrane biogenesis
E4N90_06000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N90_06005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4N90_06100	COG0095	Lipoate-protein ligase
E4N90_06105	COG0205	6-phosphofructokinase activity
E4N90_06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N90_06115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N90_06120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N90_06140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N90_06155	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N90_06175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N90_06180	COG0142	geranyltranstransferase activity
E4N90_06190	COG1692	metallophosphoesterase
E4N90_06210	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N90_06240	COG1136	(ABC) transporter
E4N90_06245	COG0577	efflux transmembrane transporter activity
E4N90_06245	COG1136	(ABC) transporter
E4N90_06260	COG3470	protein probably involved in high-affinity Fe2 transport
E4N90_06265	COG0672	)-iron permease
E4N90_06270	COG1136	(ABC) transporter
E4N90_06300	COG1760	l-serine dehydratase
E4N90_06305	COG1760	l-serine dehydratase
E4N90_06315	COG0254	rRNA binding
E4N90_06320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N90_06335	COG0574	Belongs to the PEP-utilizing enzyme family
E4N90_06335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N90_06345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N90_06350	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N90_06360	COG1196	nuclear chromosome segregation
E4N90_06370	COG2201	protein-glutamate methylesterase activity
E4N90_06380	COG0835	chemotaxis
E4N90_06385	COG0643	Histidine kinase
E4N90_06385	COG2198	Histidine kinase
E4N90_06400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N90_06405	COG0217	transcriptional regulatory protein
E4N90_06455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N90_06460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N90_06470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N90_06470	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N90_06485	COG0802	atpase or kinase
E4N90_06495	COG2770	Histidine kinase
E4N90_06495	COG3437	response regulator, receiver
E4N90_06500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N90_06510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N90_06520	COG0009	L-threonylcarbamoyladenylate synthase
E4N90_06560	COG2190	(PTS) system
E4N90_06560	COG2211	Major facilitator Superfamily
E4N90_06575	COG1193	negative regulation of DNA recombination
E4N90_06580	COG1162	GTPase activity
E4N90_06590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N90_06605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N90_06615	COG0124	histidyl-tRNA synthetase
E4N90_06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N90_06635	COG0297	glycogen (starch) synthase activity
E4N90_06645	COG0706	membrane insertase activity
E4N90_06650	COG1215	transferase activity, transferring glycosyl groups
E4N90_06650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4N90_06655	COG1216	Glycosyl transferase, family 2
E4N90_06665	COG0438	transferase activity, transferring glycosyl groups
E4N90_06670	COG0463	Glycosyl transferase, family 2
E4N90_06675	COG1216	Glycosyl transferase, family 2
E4N90_06675	COG1442	glycosyl transferase family 8
E4N90_06710	COG1216	Glycosyl transferase, family 2
E4N90_06745	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N90_06745	COG0028	Belongs to the TPP enzyme family
E4N90_06755	COG0475	glutathione-regulated potassium exporter activity
E4N90_06780	COG1078	dGTPase activity
E4N90_06790	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N90_06800	COG0488	(ABC) transporter
E4N90_06810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N90_06810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N90_06815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N90_06855	COG4658	electron transport chain
E4N90_06860	COG4656	Part of a membrane complex involved in electron transport
E4N90_06875	COG0564	pseudouridine synthase activity
E4N90_06885	COG2217	Heavy metal translocating P-type atpase
E4N90_06890	COG0640	Transcriptional regulator
E4N90_06895	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N90_06925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N90_06960	COG0557	exoribonuclease II activity
E4N90_06965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N90_06965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N90_06970	COG0556	nucleotide-excision repair
E4N90_06980	COG0346	lactoylglutathione lyase activity
E4N90_06985	COG0525	valine-tRNA ligase activity
E4N90_07000	COG2252	PERMEase
E4N90_07035	COG0772	Belongs to the SEDS family
E4N90_07040	COG0768	penicillin binding
E4N90_07055	COG1077	Cell shape determining protein MreB Mrl
E4N90_07075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N90_07080	COG0358	DNA primase activity
E4N90_07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N90_07095	COG0457	Tetratricopeptide repeat
E4N90_07100	COG0037	tRNA processing
E4N90_07105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N90_07115	COG2088	sporulation resulting in formation of a cellular spore
E4N90_07120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N90_07145	COG0330	HflC and HflK could
E4N90_07150	COG0330	HflC and HflK could
E4N90_07160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N90_07185	COG1739	Uncharacterized protein family UPF0029
E4N90_07210	COG2604	Protein of unknown function DUF115
E4N90_07215	COG0768	penicillin binding
E4N90_07225	COG0433	COG0433 Predicted ATPase
E4N90_07230	COG3842	ATPase activity
E4N90_07240	COG0312	modulator of DNA gyrase
E4N90_07245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N90_07275	COG0497	DNA recombination
E4N90_07295	COG0791	NLP P60 protein
E4N90_07295	COG1388	LysM domain
E4N90_07305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N90_07310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N90_07315	COG0312	modulator of DNA gyrase
E4N90_07345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N90_07350	COG0840	transmembrane signaling receptor activity
E4N90_07375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N90_07380	COG4475	Protein of unknown function (DUF436)
E4N90_07390	COG0601	transmembrane transport
E4N90_07395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_07405	COG0444	Belongs to the ABC transporter superfamily
E4N90_07410	COG4608	Belongs to the ABC transporter superfamily
E4N90_07435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N90_07440	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N90_07445	COG3118	belongs to the thioredoxin family
E4N90_07460	COG4750	Nucleotidyl transferase
E4N90_07465	COG1115	amino acid carrier protein
E4N90_07490	COG1193	negative regulation of DNA recombination
E4N90_07545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N90_07550	COG1480	7TM receptor with intracellular HD hydrolase
E4N90_07555	COG1702	phosphate starvation-inducible protein PhoH
E4N90_07570	COG0149	triose-phosphate isomerase activity
E4N90_07595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N90_07610	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N90_07615	COG1121	(ABC) transporter
E4N90_07620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N90_07625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N90_07650	COG1157	protein secretion by the type III secretion system
E4N90_07655	COG1317	bacterial-type flagellum organization
E4N90_07665	COG1766	The M ring may be actively involved in energy transduction
E4N90_07670	COG1677	Flagellar hook-basal body complex protein FliE
E4N90_07685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N90_07690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N90_07695	COG4974	Belongs to the 'phage' integrase family
E4N90_07700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N90_07700	COG0551	DNA topoisomerase type I activity
E4N90_07705	COG0758	DNA mediated transformation
E4N90_07715	COG4974	Belongs to the 'phage' integrase family
E4N90_07720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N90_07735	COG0772	Belongs to the SEDS family
E4N90_07740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N90_07750	COG0275	rRNA processing
E4N90_07755	COG2001	Belongs to the MraZ family
E4N90_07760	COG1505	serine-type exopeptidase activity
E4N90_07800	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N90_07810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4N90_07830	COG1120	ATPase activity
E4N90_07835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N90_07840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N90_07845	COG1846	Transcriptional regulator
E4N90_07850	COG0500	methyltransferase
E4N90_07860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N90_07865	COG1120	ATPase activity
E4N90_07875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N90_07880	COG0459	protein refolding
E4N90_07895	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N90_07905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N90_07965	COG3033	Beta-eliminating lyase
E4N90_07990	COG0563	adenylate kinase activity
E4N90_08010	COG0779	Required for maturation of 30S ribosomal subunits
E4N90_08020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N90_08025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N90_08030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N90_08125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N90_08130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N90_08140	COG3330	Domain of unknown function (DUF4912)
E4N90_08155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N90_08165	COG3706	GGDEF domain
E4N90_08170	COG1102	Psort location Cytoplasmic, score
E4N90_08175	COG1561	YicC-like family, N-terminal region
E4N90_08190	COG0564	pseudouridine synthase activity
E4N90_08205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N90_08210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N90_08215	COG0426	domain, Protein
E4N90_08215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N90_08225	COG4608	Belongs to the ABC transporter superfamily
E4N90_08230	COG0444	Belongs to the ABC transporter superfamily
E4N90_08235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_08255	COG0601	transmembrane transport
E4N90_08260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_08265	COG0444	Belongs to the ABC transporter superfamily
E4N90_08270	COG4608	Belongs to the ABC transporter superfamily
E4N90_08290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N90_08290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N90_08330	COG0534	Mate efflux family protein
E4N90_08335	COG0840	transmembrane signaling receptor activity
E4N90_08360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N90_08365	COG0049	tRNA binding
E4N90_08370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N90_08380	COG2832	Protein of unknown function (DUF454)
E4N90_08395	COG0756	dUTP diphosphatase activity
E4N90_08400	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N90_08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N90_08410	COG0196	riboflavin kinase activity
E4N90_08435	COG0598	Magnesium transport protein CorA
E4N90_08440	COG0617	tRNA 3'-terminal CCA addition
E4N90_08450	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N90_08455	COG0571	ribonuclease III activity
E4N90_08460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N90_08465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N90_08475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N90_08495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N90_08495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N90_08510	COG1067	ATP-dependent peptidase activity
E4N90_08520	COG2703	oxygen carrier activity
E4N90_08525	COG2183	response to ionizing radiation
E4N90_08535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N90_08545	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N90_08555	COG4786	Flagellar basal body rod
E4N90_08580	COG2084	Dehydrogenase
E4N90_08585	COG2116	formate transmembrane transporter activity
E4N90_08590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4N90_08610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N90_08620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N90_08625	COG4166	transmembrane transport
E4N90_08630	COG4166	transmembrane transport
E4N90_08635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_08640	COG4174	ABC transporter (Permease)
E4N90_08655	COG0747	negative chemotaxis
E4N90_08660	COG4608	Belongs to the ABC transporter superfamily
E4N90_08665	COG0444	Belongs to the ABC transporter superfamily
E4N90_08675	COG4239	(ABC) transporter, permease
E4N90_08680	COG4174	ABC transporter (Permease)
E4N90_08695	COG0017	Asparaginyl-tRNA synthetase
E4N90_08700	COG1686	Belongs to the peptidase S11 family
E4N90_08705	COG2003	Belongs to the UPF0758 family
E4N90_08710	COG1040	competence protein
E4N90_08715	COG0018	arginyl-trna synthetase
E4N90_08730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N90_08740	COG0084	hydrolase, TatD family'
E4N90_08745	COG1692	metallophosphoesterase
E4N90_08755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N90_08765	COG0484	heat shock protein binding
E4N90_08770	COG2089	acid synthase
E4N90_08775	COG5341	Protein conserved in bacteria
E4N90_08780	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N90_08785	COG0584	glycerophosphoryl diester phosphodiesterase
E4N90_08790	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N90_08795	COG1704	LemA family
E4N90_08800	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N90_08805	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N90_08810	COG3845	ABC transporter
E4N90_08815	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N90_08830	COG0148	phosphopyruvate hydratase activity
E4N90_08840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N90_08860	COG0318	PFAM AMP-dependent synthetase and ligase
E4N90_08865	COG0791	NLP P60 protein
E4N90_08875	COG3735	TraB family
E4N90_08880	COG0116	Belongs to the methyltransferase superfamily
E4N90_08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N90_08890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N90_08895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N90_08905	COG0534	Mate efflux family protein
E4N90_08910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N90_08915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N90_08920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N90_08935	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N90_08945	COG1132	(ABC) transporter
E4N90_08950	COG1132	(ABC) transporter
E4N90_08955	COG1132	(ABC) transporter
E4N90_08965	COG1132	(ABC) transporter
E4N90_08990	COG1132	(ABC) transporter
E4N90_09000	COG1129	ABC transporter
E4N90_09010	COG0210	DNA helicase
E4N90_09025	COG1129	ABC transporter
E4N90_09040	COG1132	(ABC) transporter
E4N90_09045	COG1132	(ABC) transporter
E4N90_09050	COG2207	Transcriptional regulator
E4N90_09060	COG4555	ABC transporter
E4N90_09070	COG2378	regulation of single-species biofilm formation
E4N90_09100	COG0335	large ribosomal subunit rRNA binding
E4N90_09105	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N90_09110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N90_09115	COG1837	Belongs to the UPF0109 family
E4N90_09120	COG0228	four-way junction DNA binding
E4N90_09155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N90_09160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N90_09165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N90_09170	COG0737	Belongs to the 5'-nucleotidase family
E4N90_09200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N90_09205	COG1285	pathogenesis
E4N90_09220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N90_09225	COG1187	pseudouridine synthase activity
E4N90_09250	COG2197	response regulator
E4N90_09255	COG2137	regulation of response to DNA damage stimulus
E4N90_09265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N90_09290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N90_09300	COG0574	Belongs to the PEP-utilizing enzyme family
E4N90_09300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N90_09315	COG2304	oxidoreductase activity
E4N90_09325	COG1054	Belongs to the UPF0176 family
E4N90_09330	COG4656	Part of a membrane complex involved in electron transport
E4N90_09335	COG4658	electron transport chain
E4N90_09340	COG4659	FMN binding
E4N90_09345	COG4660	Part of a membrane complex involved in electron transport
E4N90_09350	COG4657	Part of a membrane complex involved in electron transport
E4N90_09370	COG1362	aminopeptidase activity
E4N90_09375	COG0445	tRNA wobble uridine modification
E4N90_09380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N90_09385	COG2340	Cysteine-rich secretory protein family
E4N90_09390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N90_09405	COG1132	(ABC) transporter
E4N90_09410	COG1132	(ABC) transporter
E4N90_09455	COG1690	Belongs to the RtcB family
E4N90_09465	COG2910	NAD(P)H-binding
E4N90_09470	COG1959	2 iron, 2 sulfur cluster binding
E4N90_09475	COG2226	methyltransferase
E4N90_09500	COG1254	Belongs to the acylphosphatase family
E4N90_09525	COG0203	ribosomal protein L17
E4N90_09530	COG0202	RNA polymerase activity
E4N90_09535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N90_09540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N90_09545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N90_09555	COG0200	Binds to the 23S rRNA
E4N90_09560	COG1841	ribosomal large subunit assembly
E4N90_09565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N90_09570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N90_09575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N90_09580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N90_09585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N90_09590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N90_09595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N90_09600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N90_09605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N90_09610	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N90_09615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N90_09620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N90_09625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N90_09630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N90_09635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N90_09640	COG0089	rRNA binding
E4N90_09645	COG0088	Forms part of the polypeptide exit tunnel
E4N90_09650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N90_09655	COG0051	transcription antitermination factor activity, RNA binding
E4N90_09660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N90_09690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N90_09695	COG1120	ATPase activity
E4N90_09700	COG1757	Na H antiporter
E4N90_09715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N90_09725	COG3118	belongs to the thioredoxin family
E4N90_09740	COG1012	belongs to the aldehyde dehydrogenase family
E4N90_09775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N90_09810	COG1086	Polysaccharide biosynthesis protein
E4N90_09850	COG0330	HflC and HflK could
E4N90_09865	COG1131	(ABC) transporter
E4N90_09895	COG1131	(ABC) transporter
E4N90_09900	COG0351	phosphomethylpyrimidine kinase
E4N90_09920	COG1132	(ABC) transporter
E4N90_09925	COG0482	sulfurtransferase activity
E4N90_09940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N90_09945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N90_09950	COG1028	Short-chain dehydrogenase reductase Sdr
E4N90_09955	COG0629	single-stranded DNA binding
E4N90_09960	COG1862	Preprotein translocase
E4N90_09965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N90_09970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N90_09975	COG1104	cysteine desulfurase activity
E4N90_09985	COG0425	Belongs to the sulfur carrier protein TusA family
E4N90_10025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N90_10035	COG0719	Fe-S assembly protein
E4N90_10040	COG0396	ATPase activity
E4N90_10045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N90_10045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N90_10045	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N90_10045	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N90_10050	COG2885	chlorophyll binding
E4N90_10080	COG2378	regulation of single-species biofilm formation
E4N90_10095	COG1136	(ABC) transporter
E4N90_10100	COG5002	protein histidine kinase activity
E4N90_10110	COG1473	amidohydrolase
E4N90_10125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N90_10145	COG2201	protein-glutamate methylesterase activity
E4N90_10165	COG1137	ATPase activity
E4N90_10170	COG0193	aminoacyl-tRNA hydrolase activity
E4N90_10180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N90_10190	COG0601	transmembrane transport
E4N90_10195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_10200	COG0444	Belongs to the ABC transporter superfamily
E4N90_10205	COG4608	Belongs to the ABC transporter superfamily
E4N90_10215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N90_10240	COG0484	heat shock protein binding
E4N90_10245	COG0443	Heat shock 70 kDa protein
E4N90_10250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N90_10275	COG1120	ATPase activity
E4N90_10300	COG0534	Mate efflux family protein
E4N90_10320	COG1192	Involved in chromosome partitioning
E4N90_10325	COG1475	DNA binding
E4N90_10345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N90_10350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N90_10355	COG1028	Short-chain dehydrogenase reductase Sdr
E4N90_10360	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N90_10380	COG0511	ligase activity, forming carbon-carbon bonds
E4N90_10385	COG0439	Biotin carboxylase
E4N90_10390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N90_10395	COG0825	malonyl-CoA metabolic process
E4N90_10400	COG2986	histidine ammonia-lyase
E4N90_10415	COG0701	Predicted permease
E4N90_10420	COG3689	TIGRFAM TIGR03943 family protein
E4N90_10425	COG0714	Associated with various cellular activities
E4N90_10460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N90_10465	COG0154	amidase activity
E4N90_10470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N90_10645	COG1136	(ABC) transporter
E4N90_10840	COG1396	sequence-specific DNA binding
E4N90_10850	COG3550	peptidyl-serine autophosphorylation
E4N90_10870	COG3850	Histidine kinase
E4N90_10870	COG5002	protein histidine kinase activity
E4N90_10875	COG0745	RESPONSE REGULATOR receiver
E4N90_10905	COG4555	ABC transporter
E4N90_10935	COG1151	hydroxylamine reductase activity
E4N90_10950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N90_10955	COG1136	(ABC) transporter
E4N90_10955	COG0577	efflux transmembrane transporter activity
E4N90_10980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N90_11015	COG0813	purine-nucleoside phosphorylase activity
E4N90_11020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N90_11040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N90_11045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N90_11065	COG2235	arginine
E4N90_11070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N90_11080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N90_11100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N90_11120	COG0515	serine threonine protein kinase
E4N90_11145	COG0343	queuine tRNA-ribosyltransferase activity
E4N90_11155	COG1381	Involved in DNA repair and RecF pathway recombination
E4N90_11160	COG0514	ATP-dependent DNA helicase (RecQ)
E4N90_11165	COG1592	Rubrerythrin
E4N90_11205	COG0501	Belongs to the peptidase M48B family
E4N90_11215	COG0543	2 iron, 2 sulfur cluster binding
E4N90_11245	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N90_11260	COG0747	negative chemotaxis
E4N90_11265	COG4608	Belongs to the ABC transporter superfamily
E4N90_11270	COG0444	Belongs to the ABC transporter superfamily
E4N90_11275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_11290	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N90_11305	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N90_11325	COG1653	transport
E4N90_11330	COG0395	ABC-type sugar transport system, permease component
E4N90_11335	COG1175	transmembrane transport
E4N90_11340	COG3842	ATPase activity
E4N90_11355	COG0747	negative chemotaxis
E4N90_11360	COG0601	transmembrane transport
E4N90_11365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_11370	COG0444	Belongs to the ABC transporter superfamily
E4N90_11375	COG4608	Belongs to the ABC transporter superfamily
E4N90_11380	COG4166	transmembrane transport
E4N90_11385	COG0601	transmembrane transport
E4N90_11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N90_11395	COG0444	Belongs to the ABC transporter superfamily
E4N90_11400	COG4608	Belongs to the ABC transporter superfamily
E4N90_11405	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N90_11410	COG4133	protoheme IX ABC transporter activity
E4N90_11440	COG3842	ATPase activity
E4N90_11445	COG0438	transferase activity, transferring glycosyl groups
E4N90_11455	COG1132	(ABC) transporter
E4N90_11460	COG2274	protein secretion by the type I secretion system
E4N90_11460	COG3271	cysteine-type peptidase activity
E4N90_11470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N90_11490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N90_11500	COG1132	(ABC) transporter
E4N90_11515	COG0786	glutamate:sodium symporter activity
E4N90_11520	COG1132	(ABC) transporter
E4N90_11525	COG1132	(ABC) transporter
E4N90_11550	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N90_11560	COG0698	ribose 5-phosphate isomerase
E4N90_11565	COG0039	L-malate dehydrogenase activity
E4N90_11570	COG0534	Mate efflux family protein
E4N90_11575	COG0574	Belongs to the PEP-utilizing enzyme family
E4N90_11575	COG3848	Pyruvate phosphate dikinase
E4N90_11580	COG1309	transcriptional regulator
E4N90_11590	COG0840	transmembrane signaling receptor activity
E4N90_11590	COG0840	transmembrane signaling receptor activity
E4N90_11605	COG0728	peptidoglycan biosynthetic process
E4N90_11610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N90_11615	COG3588	fructose-bisphosphate aldolase
E4N90_11620	COG1309	transcriptional regulator
E4N90_11635	COG0363	glucosamine-6-phosphate deaminase activity
E4N90_11640	COG0628	permease
E4N90_11645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N90_11655	COG0534	Mate efflux family protein
E4N90_11660	COG1309	transcriptional regulator
E4N90_11670	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N90_11675	COG1518	maintenance of DNA repeat elements
E4N90_11685	COG0514	ATP-dependent DNA helicase (RecQ)
E4N90_11710	COG4536	flavin adenine dinucleotide binding
E4N90_11715	COG4536	flavin adenine dinucleotide binding
E4N90_11720	COG0714	Associated with various cellular activities
E4N90_11735	COG1132	(ABC) transporter
E4N90_11750	COG0569	domain protein
E4N90_11755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N90_11760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N90_11780	COG0616	signal peptide processing
E4N90_11785	COG0012	GTP binding
E4N90_11810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N90_11835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N90_11840	COG0569	domain protein
E4N90_11850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N90_11865	COG3271	cysteine-type peptidase activity
E4N90_11865	COG2274	protein secretion by the type I secretion system
E4N90_11870	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4N90_11875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N90_11890	COG1129	ABC transporter
E4N90_11925	COG1132	(ABC) transporter
E4N90_11925	COG2375	cellular response to nickel ion
E4N90_11930	COG1132	(ABC) transporter
E4N90_11980	COG1846	Transcriptional regulator
E4N90_11985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N90_12000	COG1129	ABC transporter
E4N90_12025	COG0733	neurotransmitter:sodium symporter activity
E4N90_12035	COG3189	MarR family transcriptional regulator
E4N90_12040	COG1309	transcriptional regulator
E4N90_12045	COG1132	(ABC) transporter
E4N90_12050	COG1132	(ABC) transporter
E4N90_12055	COG1132	(ABC) transporter
E4N90_12060	COG1132	(ABC) transporter
E4N90_12065	COG1129	ABC transporter
E4N90_12080	COG1129	ABC transporter
E4N90_12095	COG1132	(ABC) transporter
E4N90_12100	COG2375	cellular response to nickel ion
E4N90_12100	COG1132	(ABC) transporter
E4N90_12125	COG3118	belongs to the thioredoxin family
E4N90_12130	COG3842	ATPase activity
E4N90_12135	COG3833	ABC-type maltose transport systems, permease component
E4N90_12140	COG1175	transmembrane transport
E4N90_12150	COG1418	mRNA catabolic process
E4N90_12170	COG3177	Filamentation induced by cAMP protein fic
E4N90_12175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N90_12180	COG0592	DNA-directed DNA polymerase activity
E4N90_12185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N90_12225	COG3549	Plasmid maintenance system killer
E4N90_12320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N90_12335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N90_12340	COG1929	Belongs to the glycerate kinase type-1 family
E4N90_12345	COG2610	gluconate transmembrane transporter activity
E4N90_12360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N90_12375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N90_12420	COG2184	nucleotidyltransferase activity
E4N90_12430	COG0730	response to heat
E4N90_12460	COG4208	sulfate ABC transporter
E4N90_12470	COG0840	transmembrane signaling receptor activity
E4N90_12475	COG0840	transmembrane signaling receptor activity
E4N90_12490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N90_12495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N90_12500	COG1674	ftsk spoiiie
E4N90_12505	COG1968	undecaprenyl-diphosphatase activity
E4N90_12510	COG0419	ATPase involved in DNA repair
E4N90_12515	COG0420	3'-5' exonuclease activity
E4N90_12520	COG0840	transmembrane signaling receptor activity
E4N90_12520	COG3290	protein histidine kinase activity
E4N90_12530	COG1131	(ABC) transporter
E4N90_12550	COG0716	FMN binding
E4N90_12580	COG0800	Aldolase
E4N90_12605	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N90_12630	COG4585	Histidine kinase
E4N90_12635	COG1473	amidohydrolase
E4N90_12675	COG1823	symporter activity
E4N90_12680	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N90_12680	COG0540	Belongs to the ATCase OTCase family
E4N90_12685	COG5001	Diguanylate cyclase
E4N90_12685	COG5002	protein histidine kinase activity
E4N90_12745	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N90_12760	COG1774	PSP1 C-terminal conserved region
E4N90_12765	COG1728	Protein conserved in bacteria
E4N90_12775	COG0739	heme binding
E4N90_12790	COG0366	Alpha amylase catalytic
E4N90_12800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N90_12805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N90_12825	COG0823	Involved in the tonB-independent uptake of proteins
E4N90_12825	COG1506	peptidase
E4N90_12825	COG4946	Tricorn protease homolog
E4N90_12840	COG3177	Filamentation induced by cAMP protein fic
E4N90_12850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N90_12855	COG0215	cysteine-tRNA ligase activity
E4N90_12870	COG1305	Transglutaminase-like
E4N90_12875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N90_12880	COG0569	domain protein
E4N90_12885	COG2887	Belongs to the helicase family. UvrD subfamily
E4N90_12890	COG1074	ATP-dependent DNA helicase activity
E4N90_12950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N90_12970	COG0840	transmembrane signaling receptor activity
E4N90_12975	COG0826	peptidase U32
E4N90_12980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N90_12985	COG1509	lysine 2,3-aminomutase activity
E4N90_12990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N90_12995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N90_13010	COG0205	6-phosphofructokinase activity
E4N90_13045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N90_13065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N90_13070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N90_13075	COG1684	flagellar biosynthetic protein fliR
E4N90_13080	COG1987	bacterial-type flagellum assembly
E4N90_13105	COG1228	amidohydrolase
E4N90_13115	COG0457	Tetratricopeptide repeat
E4N90_13120	COG0280	phosphate acetyltransferase
E4N90_13130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N90_13135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N90_13155	COG1401	restriction endodeoxyribonuclease activity
E4N90_13175	COG2197	response regulator
E4N90_13195	COG1132	(ABC) transporter
E4N90_13225	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N90_13245	COG0423	glycine-tRNA ligase activity
E4N90_13250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N90_13260	COG1363	Peptidase, m42
E4N90_13280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N90_13285	COG1966	Carbon starvation protein
E4N90_13290	COG0450	alkyl hydroperoxide reductase
E4N90_13295	COG0494	nUDIX hydrolase
E4N90_13315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N90_13335	COG0187	DNA topoisomerase II activity