locus-tag	class	description
E4N83_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N83_00015	COG0587	DNA-directed DNA polymerase activity
E4N83_00040	COG0840	transmembrane signaling receptor activity
E4N83_00045	COG1132	(ABC) transporter
E4N83_00050	COG1132	(ABC) transporter
E4N83_00095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N83_00110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N83_00115	COG1360	Flagellar Motor Protein
E4N83_00120	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N83_00125	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N83_00130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N83_00130	COG1776	CheC inhibitor of MCP methylation
E4N83_00140	COG1338	Plays a role in the flagellum-specific transport system
E4N83_00200	COG4166	transmembrane transport
E4N83_00205	COG2423	ornithine cyclodeaminase activity
E4N83_00210	COG0739	heme binding
E4N83_00215	COG4545	Glutaredoxin-related protein
E4N83_00230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N83_00255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N83_00265	COG0732	type I restriction modification DNA specificity domain
E4N83_00270	COG0732	type I restriction modification DNA specificity domain
E4N83_00275	COG4974	Belongs to the 'phage' integrase family
E4N83_00295	COG3116	cell division
E4N83_00295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N83_00300	COG0084	hydrolase, TatD family'
E4N83_00315	COG2199	diguanylate cyclase activity
E4N83_00315	COG2203	Gaf domain
E4N83_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N83_00355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N83_00365	COG2239	Acts as a magnesium transporter
E4N83_00375	COG0546	phosphoglycolate phosphatase activity
E4N83_00380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N83_00415	COG2211	Major facilitator Superfamily
E4N83_00470	COG1747	RNA polymerase binding
E4N83_00470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N83_00485	COG0504	CTP synthase activity
E4N83_00495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N83_00500	COG1419	protein localization to endoplasmic reticulum
E4N83_00515	COG1191	sigma factor activity
E4N83_00545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N83_00575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N83_00580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N83_00585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N83_00595	COG0516	GMP reductase activity
E4N83_00600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N83_00620	COG0784	Response regulator, receiver
E4N83_00620	COG3437	response regulator, receiver
E4N83_00655	COG1122	ATPase activity
E4N83_00660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N83_00665	COG1131	(ABC) transporter
E4N83_00675	COG1132	(ABC) transporter
E4N83_00680	COG0095	Lipoate-protein ligase
E4N83_00690	COG1136	(ABC) transporter
E4N83_00695	COG2205	protein histidine kinase activity
E4N83_00705	COG4175	Glycine betaine
E4N83_00705	COG0517	IMP dehydrogenase activity
E4N83_00715	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N83_00730	COG3177	Filamentation induced by cAMP protein fic
E4N83_00780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_00790	COG0747	negative chemotaxis
E4N83_00800	COG1132	(ABC) transporter
E4N83_00800	COG2375	cellular response to nickel ion
E4N83_00805	COG1132	(ABC) transporter
E4N83_00820	COG1129	ABC transporter
E4N83_00855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N83_00870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N83_00875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N83_00880	COG1477	protein flavinylation
E4N83_00900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N83_00915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N83_00920	COG0406	alpha-ribazole phosphatase activity
E4N83_00935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N83_00945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N83_00955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N83_00965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N83_00990	COG0724	RNA recognition motif
E4N83_00995	COG1054	Belongs to the UPF0176 family
E4N83_01000	COG1362	aminopeptidase activity
E4N83_01015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N83_01020	COG3290	protein histidine kinase activity
E4N83_01020	COG0840	transmembrane signaling receptor activity
E4N83_01040	COG3706	GGDEF domain
E4N83_01045	COG3706	GGDEF domain
E4N83_01050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N83_01065	COG0564	pseudouridine synthase activity
E4N83_01075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N83_01080	COG0166	Belongs to the GPI family
E4N83_01085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N83_01090	COG4443	Transcriptional Coactivator p15 (PC4)
E4N83_01095	COG0328	RNA-DNA hybrid ribonuclease activity
E4N83_01100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N83_01105	COG0301	tRNA thio-modification
E4N83_01125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N83_01130	COG1121	(ABC) transporter
E4N83_01140	COG4988	ABC transporter
E4N83_01145	COG1132	(ABC) transporter
E4N83_01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N83_01165	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N83_01170	COG1132	(ABC) transporter
E4N83_01190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N83_01240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N83_01265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N83_01280	COG2604	Protein of unknown function DUF115
E4N83_01300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N83_01325	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N83_01330	COG1012	belongs to the aldehyde dehydrogenase family
E4N83_01335	COG1132	(ABC) transporter
E4N83_01340	COG1132	(ABC) transporter
E4N83_01360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N83_01395	COG0840	transmembrane signaling receptor activity
E4N83_01405	COG1573	uracil-dna glycosylase
E4N83_01410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N83_01415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N83_01455	COG0326	Molecular chaperone. Has ATPase activity
E4N83_01465	COG0322	excinuclease ABC activity
E4N83_01470	COG1921	L-seryl-tRNASec selenium transferase activity
E4N83_01475	COG0549	Belongs to the carbamate kinase family
E4N83_01490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N83_01500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N83_01515	COG0425	Belongs to the sulfur carrier protein TusA family
E4N83_01535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N83_01580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N83_01585	COG0666	response to abiotic stimulus
E4N83_01590	COG2078	PFAM AMMECR1 domain protein
E4N83_01590	COG3885	ferrous iron binding
E4N83_01600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N83_01605	COG0281	malic enzyme
E4N83_01610	COG2274	protein secretion by the type I secretion system
E4N83_01615	COG1363	Peptidase, m42
E4N83_01620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4N83_01650	COG1652	LysM domain
E4N83_01680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N83_01690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N83_01695	COG0250	Participates in transcription elongation, termination and antitermination
E4N83_01700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N83_01705	COG0081	regulation of translation
E4N83_01710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N83_01715	COG0222	ribosome binding
E4N83_01720	COG0085	RNA polymerase activity
E4N83_01725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N83_01730	COG0601	transmembrane transport
E4N83_01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_01740	COG4172	Belongs to the ABC transporter superfamily
E4N83_01800	COG0058	SHG alpha-glucan phosphorylase activity
E4N83_01805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N83_01825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N83_01845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N83_01855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N83_01860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N83_01870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N83_01875	COG0706	membrane insertase activity
E4N83_01880	COG1847	R3H domain protein
E4N83_01890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N83_01900	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4N83_01905	COG0740	serine-type endopeptidase activity
E4N83_01920	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N83_01930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N83_01940	COG4585	Histidine kinase
E4N83_01955	COG1131	(ABC) transporter
E4N83_01960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N83_01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N83_01995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N83_02000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N83_02040	COG2376	Dihydroxyacetone kinase
E4N83_02055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_02065	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N83_02070	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N83_02095	COG1413	lyase activity
E4N83_02100	COG0424	maF-like protein
E4N83_02105	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N83_02110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N83_02115	COG0233	cytoplasmic translational termination
E4N83_02120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N83_02125	COG0575	Belongs to the CDS family
E4N83_02130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N83_02135	COG0750	zinc metalloprotease
E4N83_02145	COG0495	leucyl-tRNA aminoacylation
E4N83_02155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N83_02160	COG0210	DNA helicase
E4N83_02170	COG2949	membrane
E4N83_02195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N83_02200	COG0542	response to heat
E4N83_02215	COG2197	response regulator
E4N83_02220	COG0668	transmembrane transport
E4N83_02245	COG0741	lytic transglycosylase activity
E4N83_02245	COG1196	nuclear chromosome segregation
E4N83_02245	COG0739	heme binding
E4N83_02250	COG1272	protein, Hemolysin III
E4N83_02265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N83_02290	COG3604	Transcriptional regulator
E4N83_02310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N83_02325	COG0792	nuclease activity
E4N83_02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N83_02345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N83_02350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N83_02370	COG0668	transmembrane transport
E4N83_02385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N83_02390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N83_02390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N83_02395	COG1329	Transcriptional regulator
E4N83_02400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N83_02410	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N83_02415	COG3956	TIGRFAM MazG family protein
E4N83_02435	COG1136	(ABC) transporter
E4N83_02435	COG0577	efflux transmembrane transporter activity
E4N83_02440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N83_02455	COG1639	'signal transduction protein
E4N83_02460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N83_02470	COG0101	tRNA pseudouridine synthase activity
E4N83_02485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N83_02495	COG1132	(ABC) transporter
E4N83_02500	COG0657	acetylesterase activity
E4N83_02505	COG0826	peptidase U32
E4N83_02520	COG1120	ATPase activity
E4N83_02525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_02535	COG0737	Belongs to the 5'-nucleotidase family
E4N83_02565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N83_02590	COG3142	Participates in the control of copper homeostasis
E4N83_02605	COG0463	Glycosyl transferase, family 2
E4N83_02625	COG4865	methylaspartate mutase activity
E4N83_02640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_02645	COG1120	ATPase activity
E4N83_02660	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N83_02670	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N83_02690	COG0442	prolyl-tRNA aminoacylation
E4N83_02705	COG1879	ABC-type sugar transport system periplasmic component
E4N83_02710	COG1129	ABC transporter
E4N83_02715	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N83_02730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N83_02750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N83_02770	COG2056	Na+-H+ antiporter family
E4N83_02775	COG1757	Na H antiporter
E4N83_02785	COG0626	cystathionine gamma-synthase activity
E4N83_02790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N83_02795	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N83_02795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N83_02795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N83_02795	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N83_02800	COG0564	pseudouridine synthase activity
E4N83_02805	COG0156	8-amino-7-oxononanoate synthase activity
E4N83_02815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N83_02825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N83_02825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N83_02830	COG0739	heme binding
E4N83_02840	COG1475	DNA binding
E4N83_02845	COG1022	Amp-dependent synthetase and ligase
E4N83_02870	COG0671	phosphoesterase, PA-phosphatase related
E4N83_02875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N83_02895	COG1028	Short-chain dehydrogenase reductase Sdr
E4N83_02950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N83_02960	COG2738	Putative neutral zinc metallopeptidase
E4N83_02965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4N83_02965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4N83_02970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N83_02980	COG1129	ABC transporter
E4N83_02995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N83_03000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N83_03010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N83_03015	COG1671	Belongs to the UPF0178 family
E4N83_03025	COG0741	lytic transglycosylase activity
E4N83_03025	COG1388	LysM domain
E4N83_03050	COG3681	Belongs to the UPF0597 family
E4N83_03055	COG4953	penicillin-binding protein 1C
E4N83_03090	COG1122	ATPase activity
E4N83_03130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N83_03175	COG1131	(ABC) transporter
E4N83_03195	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N83_03200	COG0513	Belongs to the DEAD box helicase family
E4N83_03210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N83_03245	COG3876	Protein conserved in bacteria
E4N83_03250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N83_03275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N83_03280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N83_03285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N83_03290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N83_03295	COG0484	heat shock protein binding
E4N83_03300	COG0528	UMP kinase activity
E4N83_03305	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N83_03320	COG0539	negative regulation of cytoplasmic translation
E4N83_03325	COG2204	response regulator
E4N83_03330	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N83_03345	COG5001	Diguanylate cyclase
E4N83_03350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N83_03375	COG0251	oxidation-reduction process
E4N83_03385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N83_03390	COG1722	exodeoxyribonuclease VII activity
E4N83_03400	COG1918	ferrous iron import across plasma membrane
E4N83_03405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4N83_03405	COG1918	ferrous iron import across plasma membrane
E4N83_03450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N83_03470	COG4166	transmembrane transport
E4N83_03485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N83_03500	COG0552	protein localization to endoplasmic reticulum
E4N83_03510	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N83_03515	COG1136	(ABC) transporter
E4N83_03525	COG3880	PFAM UvrB UvrC protein
E4N83_03530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N83_03540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N83_03545	COG0438	transferase activity, transferring glycosyl groups
E4N83_03555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N83_03565	COG0084	hydrolase, TatD family'
E4N83_03570	COG2885	chlorophyll binding
E4N83_03640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N83_03645	COG1132	(ABC) transporter
E4N83_03650	COG2375	cellular response to nickel ion
E4N83_03650	COG1132	(ABC) transporter
E4N83_03660	COG1309	transcriptional regulator
E4N83_03710	COG1164	Oligoendopeptidase f
E4N83_03720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N83_03725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N83_03730	COG0606	chelatase, subunit chli
E4N83_03740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4N83_03740	COG2885	chlorophyll binding
E4N83_03750	COG1199	ATP-dependent helicase activity
E4N83_03775	COG4254	PFAM FecR protein
E4N83_03825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N83_03830	COG1286	toxin biosynthetic process
E4N83_03835	COG0470	DNA polymerase III
E4N83_03840	COG3852	Histidine kinase
E4N83_03845	COG2204	response regulator
E4N83_03850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N83_03860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N83_03865	COG0475	glutathione-regulated potassium exporter activity
E4N83_03870	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N83_03945	COG1234	tRNA 3'-trailer cleavage
E4N83_03950	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N83_03955	COG3845	ABC transporter
E4N83_03960	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N83_03965	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N83_03995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N83_04100	COG1047	Peptidyl-prolyl cis-trans
E4N83_04125	COG0731	radical SAM domain protein
E4N83_04140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N83_04145	COG1979	alcohol dehydrogenase
E4N83_04150	COG2255	four-way junction helicase activity
E4N83_04160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N83_04165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N83_04180	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N83_04190	COG0653	protein targeting
E4N83_04195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N83_04200	COG0138	bifunctional purine biosynthesis protein purh
E4N83_04205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N83_04210	COG2878	Part of a membrane complex involved in electron transport
E4N83_04215	COG0481	GTPase activity
E4N83_04225	COG1114	Component of the transport system for branched-chain amino acids
E4N83_04240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N83_04255	COG2723	6-phospho-beta-galactosidase activity
E4N83_04270	COG0488	(ABC) transporter
E4N83_04280	COG0793	Belongs to the peptidase S41A family
E4N83_04355	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N83_04360	COG0632	four-way junction helicase activity
E4N83_04410	COG1136	(ABC) transporter
E4N83_04415	COG0577	efflux transmembrane transporter activity
E4N83_04415	COG1136	(ABC) transporter
E4N83_04690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N83_04705	COG1418	mRNA catabolic process
E4N83_04720	COG2033	superoxide reductase activity
E4N83_04725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N83_04730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N83_04740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N83_04745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N83_04760	COG0799	negative regulation of ribosome biogenesis
E4N83_04765	COG2059	Chromate
E4N83_04810	COG0739	heme binding
E4N83_04820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N83_04830	COG0708	Exodeoxyribonuclease III
E4N83_04835	COG0024	Methionine aminopeptidase
E4N83_04850	COG3250	beta-galactosidase activity
E4N83_04870	COG0617	tRNA 3'-terminal CCA addition
E4N83_04905	COG1846	Transcriptional regulator
E4N83_04910	COG0519	Catalyzes the synthesis of GMP from XMP
E4N83_04925	COG0126	phosphoglycerate kinase activity
E4N83_04930	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N83_04950	COG0268	Binds directly to 16S ribosomal RNA
E4N83_04955	COG0776	regulation of translation
E4N83_04960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N83_04970	COG1546	Belongs to the CinA family
E4N83_04970	COG1058	Belongs to the CinA family
E4N83_05000	COG0588	phosphoglycerate mutase activity
E4N83_05030	COG1131	(ABC) transporter
E4N83_05040	COG0457	Tetratricopeptide repeat
E4N83_05045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N83_05050	COG2203	Gaf domain
E4N83_05050	COG3706	GGDEF domain
E4N83_05050	COG4251	negative regulation of phosphorylation
E4N83_05050	COG5001	Diguanylate cyclase
E4N83_05055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N83_05060	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N83_05065	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N83_05070	COG1394	ATPase activity, coupled to movement of substances
E4N83_05075	COG1269	ATP hydrolysis coupled proton transport
E4N83_05085	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N83_05090	COG0629	single-stranded DNA binding
E4N83_05095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N83_05100	COG0359	binds to the 23S rRNA
E4N83_05110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N83_05115	COG0740	serine-type endopeptidase activity
E4N83_05120	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N83_05140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N83_05150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N83_05170	COG0305	Participates in initiation and elongation during chromosome replication
E4N83_05180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N83_05185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N83_05190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N83_05210	COG1132	(ABC) transporter
E4N83_05215	COG1132	(ABC) transporter
E4N83_05220	COG1268	BioY protein
E4N83_05225	COG1122	ATPase activity
E4N83_05245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N83_05260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N83_05265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N83_05275	COG0237	dephospho-CoA kinase activity
E4N83_05280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N83_05280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N83_05280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N83_05300	COG3052	prosthetic group binding
E4N83_05320	COG1737	Transcriptional regulator
E4N83_05335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N83_05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N83_05360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N83_05365	COG0509	glycine decarboxylation via glycine cleavage system
E4N83_05370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N83_05375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N83_05380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N83_05400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N83_05445	COG1129	ABC transporter
E4N83_05450	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N83_05455	COG0493	'glutamate synthase
E4N83_05455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N83_05465	COG0488	(ABC) transporter
E4N83_05470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N83_05480	COG0835	chemotaxis
E4N83_05490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N83_05510	COG0297	glycogen (starch) synthase activity
E4N83_05515	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N83_05520	COG2982	Protein involved in outer membrane biogenesis
E4N83_05545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N83_05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4N83_05620	COG0095	Lipoate-protein ligase
E4N83_05625	COG0205	6-phosphofructokinase activity
E4N83_05630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N83_05635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N83_05640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N83_05660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N83_05675	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N83_05695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N83_05700	COG0142	geranyltranstransferase activity
E4N83_05710	COG1692	metallophosphoesterase
E4N83_05730	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N83_05760	COG1136	(ABC) transporter
E4N83_05765	COG0577	efflux transmembrane transporter activity
E4N83_05765	COG1136	(ABC) transporter
E4N83_05780	COG3470	protein probably involved in high-affinity Fe2 transport
E4N83_05785	COG0672	)-iron permease
E4N83_05790	COG1136	(ABC) transporter
E4N83_05800	COG1760	l-serine dehydratase
E4N83_05805	COG1760	l-serine dehydratase
E4N83_05815	COG0254	rRNA binding
E4N83_05820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N83_05835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N83_05835	COG0574	Belongs to the PEP-utilizing enzyme family
E4N83_05845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N83_05850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N83_05860	COG1196	nuclear chromosome segregation
E4N83_05870	COG2201	protein-glutamate methylesterase activity
E4N83_05880	COG0835	chemotaxis
E4N83_05885	COG0643	Histidine kinase
E4N83_05885	COG2198	Histidine kinase
E4N83_05900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N83_05905	COG0217	transcriptional regulatory protein
E4N83_05955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N83_05960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N83_05970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N83_05970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N83_05985	COG0802	atpase or kinase
E4N83_05995	COG3437	response regulator, receiver
E4N83_06000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N83_06010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N83_06020	COG0009	L-threonylcarbamoyladenylate synthase
E4N83_06060	COG2211	Major facilitator Superfamily
E4N83_06060	COG2190	(PTS) system
E4N83_06075	COG1193	negative regulation of DNA recombination
E4N83_06080	COG1162	GTPase activity
E4N83_06090	COG1132	(ABC) transporter
E4N83_06095	COG1132	(ABC) transporter
E4N83_06100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N83_06115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N83_06125	COG0124	histidyl-tRNA synthetase
E4N83_06140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N83_06145	COG0297	glycogen (starch) synthase activity
E4N83_06155	COG0706	membrane insertase activity
E4N83_06165	COG0706	membrane insertase activity
E4N83_06175	COG0706	membrane insertase activity
E4N83_06180	COG0706	membrane insertase activity
E4N83_06190	COG0463	Glycosyl transferase, family 2
E4N83_06200	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N83_06205	COG1442	glycosyl transferase family 8
E4N83_06205	COG1216	Glycosyl transferase, family 2
E4N83_06245	COG1216	Glycosyl transferase, family 2
E4N83_06245	COG0463	Glycosyl transferase, family 2
E4N83_06280	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N83_06280	COG0028	Belongs to the TPP enzyme family
E4N83_06290	COG0475	glutathione-regulated potassium exporter activity
E4N83_06315	COG1078	dGTPase activity
E4N83_06325	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N83_06335	COG0488	(ABC) transporter
E4N83_06345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N83_06345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N83_06350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N83_06390	COG4658	electron transport chain
E4N83_06395	COG4656	Part of a membrane complex involved in electron transport
E4N83_06410	COG0564	pseudouridine synthase activity
E4N83_06420	COG2217	Heavy metal translocating P-type atpase
E4N83_06425	COG0640	Transcriptional regulator
E4N83_06430	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N83_06465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N83_06480	COG0557	exoribonuclease II activity
E4N83_06485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N83_06485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N83_06490	COG0556	nucleotide-excision repair
E4N83_06500	COG0346	lactoylglutathione lyase activity
E4N83_06510	COG0525	valine-tRNA ligase activity
E4N83_06525	COG2252	PERMEase
E4N83_06560	COG0772	Belongs to the SEDS family
E4N83_06565	COG0768	penicillin binding
E4N83_06580	COG1077	Cell shape determining protein MreB Mrl
E4N83_06600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N83_06605	COG0358	DNA primase activity
E4N83_06615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N83_06620	COG0457	Tetratricopeptide repeat
E4N83_06625	COG0037	tRNA processing
E4N83_06630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N83_06640	COG2088	sporulation resulting in formation of a cellular spore
E4N83_06645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N83_06670	COG0330	HflC and HflK could
E4N83_06675	COG0330	HflC and HflK could
E4N83_06685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N83_06710	COG1739	Uncharacterized protein family UPF0029
E4N83_06735	COG2604	Protein of unknown function DUF115
E4N83_06740	COG0768	penicillin binding
E4N83_06750	COG0433	COG0433 Predicted ATPase
E4N83_06760	COG0312	modulator of DNA gyrase
E4N83_06765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N83_06795	COG0497	DNA recombination
E4N83_06815	COG1388	LysM domain
E4N83_06815	COG0791	NLP P60 protein
E4N83_06825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N83_06830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N83_06835	COG0312	modulator of DNA gyrase
E4N83_06840	COG0312	modulator of DNA gyrase
E4N83_06860	COG0535	radical SAM domain protein
E4N83_06910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N83_06915	COG0840	transmembrane signaling receptor activity
E4N83_06940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N83_06945	COG4475	Protein of unknown function (DUF436)
E4N83_06955	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N83_06975	COG0601	transmembrane transport
E4N83_06980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_06990	COG0444	Belongs to the ABC transporter superfamily
E4N83_06995	COG4608	Belongs to the ABC transporter superfamily
E4N83_07030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N83_07035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N83_07040	COG3118	belongs to the thioredoxin family
E4N83_07055	COG4750	Nucleotidyl transferase
E4N83_07060	COG1115	amino acid carrier protein
E4N83_07085	COG1193	negative regulation of DNA recombination
E4N83_07135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N83_07140	COG1480	7TM receptor with intracellular HD hydrolase
E4N83_07145	COG1702	phosphate starvation-inducible protein PhoH
E4N83_07160	COG0149	triose-phosphate isomerase activity
E4N83_07170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N83_07190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N83_07205	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N83_07210	COG1121	(ABC) transporter
E4N83_07215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N83_07220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N83_07245	COG1157	protein secretion by the type III secretion system
E4N83_07250	COG1317	bacterial-type flagellum organization
E4N83_07260	COG1766	The M ring may be actively involved in energy transduction
E4N83_07265	COG1677	Flagellar hook-basal body complex protein FliE
E4N83_07280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N83_07285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N83_07290	COG4974	Belongs to the 'phage' integrase family
E4N83_07295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N83_07295	COG0551	DNA topoisomerase type I activity
E4N83_07300	COG0758	DNA mediated transformation
E4N83_07310	COG4974	Belongs to the 'phage' integrase family
E4N83_07315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N83_07330	COG0772	Belongs to the SEDS family
E4N83_07335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N83_07345	COG0275	rRNA processing
E4N83_07350	COG2001	Belongs to the MraZ family
E4N83_07355	COG1505	serine-type exopeptidase activity
E4N83_07395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N83_07405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4N83_07425	COG1120	ATPase activity
E4N83_07430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_07435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N83_07440	COG1846	Transcriptional regulator
E4N83_07445	COG0500	methyltransferase
E4N83_07455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_07460	COG1120	ATPase activity
E4N83_07470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N83_07475	COG0459	protein refolding
E4N83_07490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N83_07495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N83_07535	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N83_07555	COG3033	Beta-eliminating lyase
E4N83_07570	COG0563	adenylate kinase activity
E4N83_07590	COG0779	Required for maturation of 30S ribosomal subunits
E4N83_07600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N83_07605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N83_07610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N83_07620	COG1132	(ABC) transporter
E4N83_07625	COG1132	(ABC) transporter
E4N83_07640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_07645	COG0601	transmembrane transport
E4N83_07650	COG0747	negative chemotaxis
E4N83_07655	COG4977	sequence-specific DNA binding
E4N83_07655	COG1917	Cupin 2, conserved barrel domain protein
E4N83_07685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N83_07690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N83_07700	COG3330	Domain of unknown function (DUF4912)
E4N83_07715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N83_07725	COG3706	GGDEF domain
E4N83_07730	COG1102	Psort location Cytoplasmic, score
E4N83_07735	COG1561	YicC-like family, N-terminal region
E4N83_07750	COG0564	pseudouridine synthase activity
E4N83_07765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N83_07770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N83_07790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N83_07790	COG0426	domain, Protein
E4N83_07800	COG4608	Belongs to the ABC transporter superfamily
E4N83_07805	COG0444	Belongs to the ABC transporter superfamily
E4N83_07810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_07830	COG0601	transmembrane transport
E4N83_07835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_07840	COG0444	Belongs to the ABC transporter superfamily
E4N83_07845	COG4608	Belongs to the ABC transporter superfamily
E4N83_07865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N83_07865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N83_07900	COG0534	Mate efflux family protein
E4N83_07905	COG0840	transmembrane signaling receptor activity
E4N83_07930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N83_07935	COG0049	tRNA binding
E4N83_07940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N83_07950	COG2832	Protein of unknown function (DUF454)
E4N83_07965	COG0756	dUTP diphosphatase activity
E4N83_07970	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N83_07975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N83_07980	COG0196	riboflavin kinase activity
E4N83_07990	COG0598	Magnesium transport protein CorA
E4N83_07995	COG0617	tRNA 3'-terminal CCA addition
E4N83_08010	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N83_08015	COG0571	ribonuclease III activity
E4N83_08020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N83_08025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N83_08035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N83_08055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N83_08055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N83_08070	COG1067	ATP-dependent peptidase activity
E4N83_08080	COG2703	oxygen carrier activity
E4N83_08085	COG2183	response to ionizing radiation
E4N83_08095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N83_08105	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N83_08115	COG4786	Flagellar basal body rod
E4N83_08130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N83_08135	COG2084	Dehydrogenase
E4N83_08140	COG2116	formate transmembrane transporter activity
E4N83_08165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N83_08175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N83_08185	COG0747	negative chemotaxis
E4N83_08190	COG4608	Belongs to the ABC transporter superfamily
E4N83_08195	COG0444	Belongs to the ABC transporter superfamily
E4N83_08205	COG4239	(ABC) transporter, permease
E4N83_08210	COG4174	ABC transporter (Permease)
E4N83_08225	COG0017	Asparaginyl-tRNA synthetase
E4N83_08230	COG1686	Belongs to the peptidase S11 family
E4N83_08235	COG2003	Belongs to the UPF0758 family
E4N83_08240	COG1040	competence protein
E4N83_08245	COG0018	arginyl-trna synthetase
E4N83_08260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N83_08270	COG0084	hydrolase, TatD family'
E4N83_08275	COG1692	metallophosphoesterase
E4N83_08285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N83_08295	COG0484	heat shock protein binding
E4N83_08300	COG2089	acid synthase
E4N83_08305	COG5341	Protein conserved in bacteria
E4N83_08310	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N83_08315	COG0584	glycerophosphoryl diester phosphodiesterase
E4N83_08320	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N83_08325	COG1704	LemA family
E4N83_08330	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N83_08335	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N83_08340	COG3845	ABC transporter
E4N83_08345	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N83_08360	COG0148	phosphopyruvate hydratase activity
E4N83_08370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N83_08390	COG0318	PFAM AMP-dependent synthetase and ligase
E4N83_08395	COG0791	NLP P60 protein
E4N83_08405	COG3735	TraB family
E4N83_08410	COG0116	Belongs to the methyltransferase superfamily
E4N83_08415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N83_08420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N83_08435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N83_08440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N83_08455	COG0534	Mate efflux family protein
E4N83_08460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N83_08465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N83_08470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N83_08485	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N83_08490	COG2375	cellular response to nickel ion
E4N83_08490	COG1132	(ABC) transporter
E4N83_08495	COG1132	(ABC) transporter
E4N83_08500	COG1132	(ABC) transporter
E4N83_08505	COG1132	(ABC) transporter
E4N83_08560	COG1132	(ABC) transporter
E4N83_08570	COG1129	ABC transporter
E4N83_08595	COG1129	ABC transporter
E4N83_08610	COG1132	(ABC) transporter
E4N83_08615	COG1132	(ABC) transporter
E4N83_08615	COG2375	cellular response to nickel ion
E4N83_08620	COG2207	Transcriptional regulator
E4N83_08630	COG4555	ABC transporter
E4N83_08640	COG2378	regulation of single-species biofilm formation
E4N83_08665	COG0335	large ribosomal subunit rRNA binding
E4N83_08670	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N83_08675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N83_08680	COG1837	Belongs to the UPF0109 family
E4N83_08685	COG0228	four-way junction DNA binding
E4N83_08695	COG1136	(ABC) transporter
E4N83_08695	COG0577	efflux transmembrane transporter activity
E4N83_08700	COG1136	(ABC) transporter
E4N83_08710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N83_08715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N83_08720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N83_08725	COG0737	Belongs to the 5'-nucleotidase family
E4N83_08755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N83_08760	COG1285	pathogenesis
E4N83_08780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N83_08785	COG1187	pseudouridine synthase activity
E4N83_08810	COG2197	response regulator
E4N83_08815	COG2137	regulation of response to DNA damage stimulus
E4N83_08825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N83_08850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N83_08860	COG0574	Belongs to the PEP-utilizing enzyme family
E4N83_08860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N83_08875	COG2304	oxidoreductase activity
E4N83_08885	COG1054	Belongs to the UPF0176 family
E4N83_08890	COG4656	Part of a membrane complex involved in electron transport
E4N83_08895	COG4658	electron transport chain
E4N83_08900	COG4659	FMN binding
E4N83_08905	COG4660	Part of a membrane complex involved in electron transport
E4N83_08910	COG4657	Part of a membrane complex involved in electron transport
E4N83_08930	COG1362	aminopeptidase activity
E4N83_08935	COG0445	tRNA wobble uridine modification
E4N83_08940	COG3422	double-strand break repair
E4N83_08945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N83_08950	COG2340	Cysteine-rich secretory protein family
E4N83_08955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N83_08970	COG1132	(ABC) transporter
E4N83_08980	COG1473	amidohydrolase
E4N83_08985	COG1288	antiporter activity
E4N83_08995	COG1132	(ABC) transporter
E4N83_09030	COG1690	Belongs to the RtcB family
E4N83_09040	COG2910	NAD(P)H-binding
E4N83_09045	COG1959	2 iron, 2 sulfur cluster binding
E4N83_09065	COG1254	Belongs to the acylphosphatase family
E4N83_09090	COG0203	ribosomal protein L17
E4N83_09095	COG0202	RNA polymerase activity
E4N83_09100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N83_09105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N83_09110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N83_09120	COG0200	Binds to the 23S rRNA
E4N83_09125	COG1841	ribosomal large subunit assembly
E4N83_09130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N83_09135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N83_09140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N83_09145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N83_09150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N83_09155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N83_09160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N83_09165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N83_09170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N83_09175	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N83_09180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N83_09185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N83_09190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N83_09195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N83_09200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N83_09205	COG0089	rRNA binding
E4N83_09210	COG0088	Forms part of the polypeptide exit tunnel
E4N83_09215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N83_09220	COG0051	transcription antitermination factor activity, RNA binding
E4N83_09225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N83_09255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N83_09260	COG1120	ATPase activity
E4N83_09265	COG1757	Na H antiporter
E4N83_09285	COG3118	belongs to the thioredoxin family
E4N83_09335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N83_09405	COG1086	Polysaccharide biosynthesis protein
E4N83_09445	COG0330	HflC and HflK could
E4N83_09460	COG1131	(ABC) transporter
E4N83_09500	COG1131	(ABC) transporter
E4N83_09505	COG0351	phosphomethylpyrimidine kinase
E4N83_09515	COG0482	sulfurtransferase activity
E4N83_09530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N83_09535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N83_09540	COG1028	Short-chain dehydrogenase reductase Sdr
E4N83_09545	COG0629	single-stranded DNA binding
E4N83_09550	COG1862	Preprotein translocase
E4N83_09555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N83_09560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N83_09565	COG1104	cysteine desulfurase activity
E4N83_09575	COG0425	Belongs to the sulfur carrier protein TusA family
E4N83_09605	COG3093	addiction module antidote protein HigA
E4N83_09610	COG3549	Plasmid maintenance system killer
E4N83_09615	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N83_09625	COG0719	Fe-S assembly protein
E4N83_09630	COG0396	ATPase activity
E4N83_09635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N83_09635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N83_09635	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N83_09635	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N83_09640	COG2885	chlorophyll binding
E4N83_09650	COG4115	mRNA cleavage
E4N83_09680	COG2378	regulation of single-species biofilm formation
E4N83_09695	COG1136	(ABC) transporter
E4N83_09700	COG5002	protein histidine kinase activity
E4N83_09710	COG1473	amidohydrolase
E4N83_09725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N83_09745	COG2201	protein-glutamate methylesterase activity
E4N83_09765	COG1137	ATPase activity
E4N83_09770	COG0193	aminoacyl-tRNA hydrolase activity
E4N83_09780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N83_09785	COG0601	transmembrane transport
E4N83_09790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N83_09795	COG0444	Belongs to the ABC transporter superfamily
E4N83_09800	COG4608	Belongs to the ABC transporter superfamily
E4N83_09810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N83_09835	COG0484	heat shock protein binding
E4N83_09840	COG0443	Heat shock 70 kDa protein
E4N83_09845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N83_09855	COG0515	serine threonine protein kinase
E4N83_09855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N83_09870	COG1120	ATPase activity
E4N83_09890	COG0534	Mate efflux family protein
E4N83_09920	COG1192	Involved in chromosome partitioning
E4N83_09925	COG1475	DNA binding
E4N83_09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N83_09950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N83_09955	COG1028	Short-chain dehydrogenase reductase Sdr
E4N83_09960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N83_09980	COG0439	Biotin carboxylase
E4N83_09985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N83_09990	COG0825	malonyl-CoA metabolic process
E4N83_09995	COG2986	histidine ammonia-lyase
E4N83_10015	COG0701	Predicted permease
E4N83_10020	COG3689	TIGRFAM TIGR03943 family protein
E4N83_10025	COG0714	Associated with various cellular activities
E4N83_10060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N83_10065	COG0154	amidase activity
E4N83_10070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N83_10185	COG1309	transcriptional regulator
E4N83_10190	COG1131	(ABC) transporter
E4N83_10240	COG1136	(ABC) transporter
E4N83_10375	COG3041	Addiction module toxin RelE StbE family
E4N83_10440	COG1396	sequence-specific DNA binding
E4N83_10450	COG3550	peptidyl-serine autophosphorylation
E4N83_10460	COG3850	Histidine kinase
E4N83_10460	COG5002	protein histidine kinase activity
E4N83_10480	COG4555	ABC transporter
E4N83_10515	COG1151	hydroxylamine reductase activity
E4N83_10530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N83_10535	COG0577	efflux transmembrane transporter activity
E4N83_10535	COG1136	(ABC) transporter
E4N83_10550	COG4115	mRNA cleavage
E4N83_10565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N83_10590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N83_10615	COG0813	purine-nucleoside phosphorylase activity
E4N83_10620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N83_10640	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N83_10645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N83_10660	COG2235	arginine
E4N83_10665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N83_10675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N83_10695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N83_10725	COG0343	queuine tRNA-ribosyltransferase activity
E4N83_10735	COG1381	Involved in DNA repair and RecF pathway recombination
E4N83_10745	COG0514	ATP-dependent DNA helicase (RecQ)
E4N83_10750	COG1592	Rubrerythrin
E4N83_10820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N83_10825	COG0501	Belongs to the peptidase M48B family
E4N83_10835	COG0543	2 iron, 2 sulfur cluster binding
E4N83_10860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N83_10870	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N83_10885	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N83_10900	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N83_10905	COG4133	protoheme IX ABC transporter activity
E4N83_10950	COG3842	ATPase activity
E4N83_10955	COG0438	transferase activity, transferring glycosyl groups
E4N83_10965	COG3271	cysteine-type peptidase activity
E4N83_10965	COG2274	protein secretion by the type I secretion system
E4N83_10985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N83_10995	COG0786	glutamate:sodium symporter activity
E4N83_11000	COG1132	(ABC) transporter
E4N83_11005	COG1132	(ABC) transporter
E4N83_11025	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N83_11035	COG0698	ribose 5-phosphate isomerase
E4N83_11040	COG0039	L-malate dehydrogenase activity
E4N83_11045	COG0534	Mate efflux family protein
E4N83_11050	COG0574	Belongs to the PEP-utilizing enzyme family
E4N83_11050	COG3848	Pyruvate phosphate dikinase
E4N83_11055	COG1309	transcriptional regulator
E4N83_11065	COG0840	transmembrane signaling receptor activity
E4N83_11080	COG0728	peptidoglycan biosynthetic process
E4N83_11085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N83_11090	COG3588	fructose-bisphosphate aldolase
E4N83_11095	COG1309	transcriptional regulator
E4N83_11105	COG0363	glucosamine-6-phosphate deaminase activity
E4N83_11110	COG0628	permease
E4N83_11115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N83_11130	COG0534	Mate efflux family protein
E4N83_11135	COG1309	transcriptional regulator
E4N83_11145	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N83_11150	COG1518	maintenance of DNA repeat elements
E4N83_11155	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E4N83_11160	COG0514	ATP-dependent DNA helicase (RecQ)
E4N83_11185	COG4536	flavin adenine dinucleotide binding
E4N83_11190	COG4536	flavin adenine dinucleotide binding
E4N83_11195	COG0714	Associated with various cellular activities
E4N83_11210	COG1132	(ABC) transporter
E4N83_11225	COG0569	domain protein
E4N83_11230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N83_11235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N83_11255	COG0616	signal peptide processing
E4N83_11260	COG0012	GTP binding
E4N83_11285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N83_11290	COG0494	nUDIX hydrolase
E4N83_11305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N83_11310	COG0569	domain protein
E4N83_11320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N83_11345	COG2274	protein secretion by the type I secretion system
E4N83_11345	COG3271	cysteine-type peptidase activity
E4N83_11350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4N83_11355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N83_11370	COG1129	ABC transporter
E4N83_11400	COG2375	cellular response to nickel ion
E4N83_11400	COG1132	(ABC) transporter
E4N83_11405	COG1132	(ABC) transporter
E4N83_11445	COG1846	Transcriptional regulator
E4N83_11465	COG1129	ABC transporter
E4N83_11490	COG0733	neurotransmitter:sodium symporter activity
E4N83_11510	COG1222	aaa ATPase
E4N83_11520	COG3189	MarR family transcriptional regulator
E4N83_11525	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N83_11530	COG1309	transcriptional regulator
E4N83_11535	COG1132	(ABC) transporter
E4N83_11540	COG1132	(ABC) transporter
E4N83_11545	COG1129	ABC transporter
E4N83_11565	COG1129	ABC transporter
E4N83_11580	COG1132	(ABC) transporter
E4N83_11585	COG2375	cellular response to nickel ion
E4N83_11585	COG1132	(ABC) transporter
E4N83_11620	COG3842	ATPase activity
E4N83_11625	COG3833	ABC-type maltose transport systems, permease component
E4N83_11630	COG1175	transmembrane transport
E4N83_11640	COG1418	mRNA catabolic process
E4N83_11650	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N83_11655	COG0592	DNA-directed DNA polymerase activity
E4N83_11660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N83_11775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N83_11790	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N83_11795	COG1929	Belongs to the glycerate kinase type-1 family
E4N83_11800	COG2610	gluconate transmembrane transporter activity
E4N83_11815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N83_11830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N83_11880	COG0730	response to heat
E4N83_11910	COG4208	sulfate ABC transporter
E4N83_11925	COG0840	transmembrane signaling receptor activity
E4N83_11940	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N83_11945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N83_11950	COG1674	ftsk spoiiie
E4N83_11955	COG1968	undecaprenyl-diphosphatase activity
E4N83_11960	COG0419	ATPase involved in DNA repair
E4N83_11965	COG0420	3'-5' exonuclease activity
E4N83_11970	COG0840	transmembrane signaling receptor activity
E4N83_11970	COG3290	protein histidine kinase activity
E4N83_11980	COG1131	(ABC) transporter
E4N83_12000	COG0716	FMN binding
E4N83_12020	COG0800	Aldolase
E4N83_12040	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N83_12065	COG4585	Histidine kinase
E4N83_12070	COG1473	amidohydrolase
E4N83_12085	COG4143	(ABC) transporter
E4N83_12095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N83_12100	COG1070	Carbohydrate kinase
E4N83_12110	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N83_12120	COG2186	Transcriptional regulator
E4N83_12130	COG1823	symporter activity
E4N83_12135	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N83_12135	COG0540	Belongs to the ATCase OTCase family
E4N83_12140	COG5001	Diguanylate cyclase
E4N83_12140	COG5002	protein histidine kinase activity
E4N83_12200	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N83_12215	COG1774	PSP1 C-terminal conserved region
E4N83_12220	COG1728	Protein conserved in bacteria
E4N83_12230	COG0739	heme binding
E4N83_12245	COG0366	Alpha amylase catalytic
E4N83_12255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N83_12260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N83_12280	COG0823	Involved in the tonB-independent uptake of proteins
E4N83_12280	COG1506	peptidase
E4N83_12280	COG4946	Tricorn protease homolog
E4N83_12310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N83_12315	COG0215	cysteine-tRNA ligase activity
E4N83_12330	COG1305	Transglutaminase-like
E4N83_12335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N83_12340	COG0569	domain protein
E4N83_12345	COG2887	Belongs to the helicase family. UvrD subfamily
E4N83_12350	COG1074	ATP-dependent DNA helicase activity
E4N83_12355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N83_12375	COG1012	belongs to the aldehyde dehydrogenase family
E4N83_12385	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E4N83_12400	COG1830	Aldolase
E4N83_12405	COG1063	alcohol dehydrogenase
E4N83_12410	COG0531	amino acid
E4N83_12415	COG0196	riboflavin kinase activity
E4N83_12420	COG0840	transmembrane signaling receptor activity
E4N83_12425	COG0826	peptidase U32
E4N83_12435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N83_12440	COG1509	lysine 2,3-aminomutase activity
E4N83_12445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N83_12450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N83_12465	COG0205	6-phosphofructokinase activity
E4N83_12500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N83_12510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N83_12515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N83_12520	COG1684	flagellar biosynthetic protein fliR
E4N83_12525	COG1987	bacterial-type flagellum assembly
E4N83_12550	COG1228	amidohydrolase
E4N83_12565	COG0457	Tetratricopeptide repeat
E4N83_12570	COG0280	phosphate acetyltransferase
E4N83_12580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N83_12585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N83_12600	COG0537	adenosine 5'-monophosphoramidase activity
E4N83_12615	COG3279	Response regulator of the LytR AlgR family
E4N83_12670	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N83_12690	COG0423	glycine-tRNA ligase activity
E4N83_12695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N83_12705	COG1363	Peptidase, m42
E4N83_12725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N83_12730	COG1966	Carbon starvation protein
E4N83_12735	COG0450	alkyl hydroperoxide reductase
E4N83_12740	COG0494	nUDIX hydrolase
E4N83_12750	COG2217	Heavy metal translocating P-type atpase
E4N83_12760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N83_12780	COG0187	DNA topoisomerase II activity