locus-tag	class	description
HGJ18_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGJ18_00015	COG0587	DNA-directed DNA polymerase activity
HGJ18_00040	COG0840	transmembrane signaling receptor activity
HGJ18_00045	COG1132	(ABC) transporter
HGJ18_00050	COG1132	(ABC) transporter
HGJ18_00110	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGJ18_00125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGJ18_00130	COG1360	Flagellar Motor Protein
HGJ18_00135	COG1580	Controls the rotational direction of flagella during chemotaxis
HGJ18_00140	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_00145	COG1776	CheC inhibitor of MCP methylation
HGJ18_00145	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_00155	COG1338	Plays a role in the flagellum-specific transport system
HGJ18_00170	COG4166	transmembrane transport
HGJ18_00175	COG2423	ornithine cyclodeaminase activity
HGJ18_00180	COG0739	heme binding
HGJ18_00185	COG4545	Glutaredoxin-related protein
HGJ18_00200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGJ18_00225	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HGJ18_00235	COG0732	type I restriction modification DNA specificity domain
HGJ18_00245	COG4974	Belongs to the 'phage' integrase family
HGJ18_00265	COG3116	cell division
HGJ18_00265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGJ18_00270	COG0084	hydrolase, TatD family'
HGJ18_00285	COG2199	diguanylate cyclase activity
HGJ18_00285	COG2203	Gaf domain
HGJ18_00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGJ18_00320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGJ18_00325	COG2239	Acts as a magnesium transporter
HGJ18_00335	COG0546	phosphoglycolate phosphatase activity
HGJ18_00340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGJ18_00445	COG2211	Major facilitator Superfamily
HGJ18_00475	COG0396	ATPase activity
HGJ18_00480	COG0719	Fe-S assembly protein
HGJ18_00495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGJ18_00500	COG3549	Plasmid maintenance system killer
HGJ18_00505	COG3093	addiction module antidote protein HigA
HGJ18_00535	COG0425	Belongs to the sulfur carrier protein TusA family
HGJ18_00545	COG1104	cysteine desulfurase activity
HGJ18_00550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGJ18_00555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGJ18_00560	COG1862	Preprotein translocase
HGJ18_00565	COG0629	single-stranded DNA binding
HGJ18_00570	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_00575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGJ18_00580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGJ18_00595	COG0482	sulfurtransferase activity
HGJ18_00605	COG0351	phosphomethylpyrimidine kinase
HGJ18_00610	COG1131	(ABC) transporter
HGJ18_00650	COG1131	(ABC) transporter
HGJ18_00670	COG0330	HflC and HflK could
HGJ18_00750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGJ18_00775	COG0793	Belongs to the peptidase S41A family
HGJ18_00780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGJ18_00830	COG3118	belongs to the thioredoxin family
HGJ18_00840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_00855	COG1757	Na H antiporter
HGJ18_00865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGJ18_00870	COG0051	transcription antitermination factor activity, RNA binding
HGJ18_00875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGJ18_00880	COG0088	Forms part of the polypeptide exit tunnel
HGJ18_00885	COG0089	rRNA binding
HGJ18_00890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGJ18_00895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGJ18_00900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGJ18_00905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGJ18_00910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGJ18_00915	COG0255	Belongs to the universal ribosomal protein uL29 family
HGJ18_00920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGJ18_00925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGJ18_00930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGJ18_00935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGJ18_00940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGJ18_00945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGJ18_00950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGJ18_00955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGJ18_00960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGJ18_00965	COG1841	ribosomal large subunit assembly
HGJ18_00970	COG0200	Binds to the 23S rRNA
HGJ18_00980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGJ18_00985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGJ18_00990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGJ18_00995	COG0202	RNA polymerase activity
HGJ18_01000	COG0203	ribosomal protein L17
HGJ18_01025	COG1254	Belongs to the acylphosphatase family
HGJ18_01045	COG2226	methyltransferase
HGJ18_01050	COG1959	2 iron, 2 sulfur cluster binding
HGJ18_01055	COG2910	NAD(P)H-binding
HGJ18_01070	COG1401	restriction endodeoxyribonuclease activity
HGJ18_01090	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HGJ18_01185	COG2274	protein secretion by the type I secretion system
HGJ18_01190	COG1132	(ABC) transporter
HGJ18_01195	COG1132	(ABC) transporter
HGJ18_01220	COG1132	(ABC) transporter
HGJ18_01225	COG1129	ABC transporter
HGJ18_01240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGJ18_01250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGJ18_01255	COG3422	double-strand break repair
HGJ18_01260	COG0445	tRNA wobble uridine modification
HGJ18_01265	COG1362	aminopeptidase activity
HGJ18_01270	COG4657	Part of a membrane complex involved in electron transport
HGJ18_01275	COG4660	Part of a membrane complex involved in electron transport
HGJ18_01280	COG4659	FMN binding
HGJ18_01285	COG4658	electron transport chain
HGJ18_01290	COG4656	Part of a membrane complex involved in electron transport
HGJ18_01295	COG1054	Belongs to the UPF0176 family
HGJ18_01305	COG2304	oxidoreductase activity
HGJ18_01320	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_01320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_01330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGJ18_01355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGJ18_01365	COG2137	regulation of response to DNA damage stimulus
HGJ18_01370	COG2197	response regulator
HGJ18_01395	COG1187	pseudouridine synthase activity
HGJ18_01400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGJ18_01420	COG1285	pathogenesis
HGJ18_01425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGJ18_01460	COG0737	Belongs to the 5'-nucleotidase family
HGJ18_01465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGJ18_01470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGJ18_01475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGJ18_01500	COG0228	four-way junction DNA binding
HGJ18_01505	COG1837	Belongs to the UPF0109 family
HGJ18_01510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGJ18_01515	COG0336	Belongs to the RNA methyltransferase TrmD family
HGJ18_01520	COG0335	large ribosomal subunit rRNA binding
HGJ18_01545	COG0210	DNA helicase
HGJ18_01560	COG1129	ABC transporter
HGJ18_01570	COG2375	cellular response to nickel ion
HGJ18_01570	COG1132	(ABC) transporter
HGJ18_01575	COG1132	(ABC) transporter
HGJ18_01585	COG1132	(ABC) transporter
HGJ18_01590	COG1132	(ABC) transporter
HGJ18_01595	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGJ18_01610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HGJ18_01615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGJ18_01620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGJ18_01625	COG0534	Mate efflux family protein
HGJ18_01635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGJ18_01640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGJ18_01645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_01650	COG0116	Belongs to the methyltransferase superfamily
HGJ18_01655	COG3735	TraB family
HGJ18_01665	COG0791	NLP P60 protein
HGJ18_01670	COG0318	PFAM AMP-dependent synthetase and ligase
HGJ18_01690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_01700	COG0148	phosphopyruvate hydratase activity
HGJ18_01720	COG1744	ABC transporter substrate-binding protein PnrA-like
HGJ18_01725	COG3845	ABC transporter
HGJ18_01730	COG4603	Belongs to the binding-protein-dependent transport system permease family
HGJ18_01735	COG1079	Belongs to the binding-protein-dependent transport system permease family
HGJ18_01775	COG1704	LemA family
HGJ18_01780	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGJ18_01785	COG0584	glycerophosphoryl diester phosphodiesterase
HGJ18_01790	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGJ18_01795	COG5341	Protein conserved in bacteria
HGJ18_01800	COG2089	acid synthase
HGJ18_01805	COG0484	heat shock protein binding
HGJ18_01815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGJ18_01825	COG1692	metallophosphoesterase
HGJ18_01830	COG0084	hydrolase, TatD family'
HGJ18_01840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGJ18_01865	COG0018	arginyl-trna synthetase
HGJ18_01870	COG1040	competence protein
HGJ18_01875	COG2003	Belongs to the UPF0758 family
HGJ18_01880	COG1686	Belongs to the peptidase S11 family
HGJ18_01885	COG0017	Asparaginyl-tRNA synthetase
HGJ18_01900	COG4166	transmembrane transport
HGJ18_01905	COG4166	transmembrane transport
HGJ18_01910	COG4174	ABC transporter (Permease)
HGJ18_01915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_01920	COG4166	transmembrane transport
HGJ18_01925	COG0444	Belongs to the ABC transporter superfamily
HGJ18_01930	COG4608	Belongs to the ABC transporter superfamily
HGJ18_01935	COG4166	transmembrane transport
HGJ18_01940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGJ18_01950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGJ18_01975	COG2116	formate transmembrane transporter activity
HGJ18_01980	COG2084	Dehydrogenase
HGJ18_01995	COG4786	Flagellar basal body rod
HGJ18_02005	COG3951	Flagellar rod assembly protein muramidase FlgJ
HGJ18_02015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGJ18_02025	COG2183	response to ionizing radiation
HGJ18_02040	COG1067	ATP-dependent peptidase activity
HGJ18_02055	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HGJ18_02055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HGJ18_02075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HGJ18_02085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGJ18_02090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGJ18_02095	COG0571	ribonuclease III activity
HGJ18_02100	COG0071	Belongs to the small heat shock protein (HSP20) family
HGJ18_02115	COG0617	tRNA 3'-terminal CCA addition
HGJ18_02120	COG0598	Magnesium transport protein CorA
HGJ18_02130	COG0196	riboflavin kinase activity
HGJ18_02135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGJ18_02140	COG1185	polyribonucleotide nucleotidyltransferase activity
HGJ18_02145	COG0756	dUTP diphosphatase activity
HGJ18_02160	COG2832	Protein of unknown function (DUF454)
HGJ18_02170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGJ18_02175	COG0049	tRNA binding
HGJ18_02180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_02205	COG0840	transmembrane signaling receptor activity
HGJ18_02210	COG0534	Mate efflux family protein
HGJ18_02240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGJ18_02240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGJ18_02250	COG4608	Belongs to the ABC transporter superfamily
HGJ18_02255	COG0444	Belongs to the ABC transporter superfamily
HGJ18_02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_02265	COG0601	transmembrane transport
HGJ18_02285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_02290	COG0444	Belongs to the ABC transporter superfamily
HGJ18_02295	COG4608	Belongs to the ABC transporter superfamily
HGJ18_02300	COG0426	domain, Protein
HGJ18_02300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGJ18_02310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGJ18_02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGJ18_02330	COG0564	pseudouridine synthase activity
HGJ18_02335	COG0285	dihydrofolate synthase activity
HGJ18_02345	COG1561	YicC-like family, N-terminal region
HGJ18_02350	COG1102	Psort location Cytoplasmic, score
HGJ18_02355	COG3706	GGDEF domain
HGJ18_02365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGJ18_02380	COG3330	Domain of unknown function (DUF4912)
HGJ18_02390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGJ18_02395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGJ18_02415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGJ18_02420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGJ18_02425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGJ18_02435	COG0779	Required for maturation of 30S ribosomal subunits
HGJ18_02455	COG0563	adenylate kinase activity
HGJ18_02460	COG3033	Beta-eliminating lyase
HGJ18_02480	COG1366	Belongs to the anti-sigma-factor antagonist family
HGJ18_02520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGJ18_02525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGJ18_02540	COG0459	protein refolding
HGJ18_02560	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HGJ18_02570	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HGJ18_02610	COG1505	serine-type exopeptidase activity
HGJ18_02615	COG2001	Belongs to the MraZ family
HGJ18_02620	COG0275	rRNA processing
HGJ18_02630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGJ18_02635	COG0772	Belongs to the SEDS family
HGJ18_02650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGJ18_02655	COG4974	Belongs to the 'phage' integrase family
HGJ18_02665	COG0758	DNA mediated transformation
HGJ18_02670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGJ18_02670	COG0551	DNA topoisomerase type I activity
HGJ18_02675	COG4974	Belongs to the 'phage' integrase family
HGJ18_02680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGJ18_02685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGJ18_02700	COG1677	Flagellar hook-basal body complex protein FliE
HGJ18_02705	COG1766	The M ring may be actively involved in energy transduction
HGJ18_02715	COG1317	bacterial-type flagellum organization
HGJ18_02720	COG1157	protein secretion by the type III secretion system
HGJ18_02745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_02750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_02755	COG1121	(ABC) transporter
HGJ18_02760	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGJ18_02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGJ18_02790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGJ18_02800	COG0149	triose-phosphate isomerase activity
HGJ18_02815	COG1702	phosphate starvation-inducible protein PhoH
HGJ18_02820	COG1480	7TM receptor with intracellular HD hydrolase
HGJ18_02825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGJ18_02875	COG1193	negative regulation of DNA recombination
HGJ18_02900	COG1115	amino acid carrier protein
HGJ18_02905	COG4750	Nucleotidyl transferase
HGJ18_02910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGJ18_02920	COG3118	belongs to the thioredoxin family
HGJ18_02925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGJ18_02930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGJ18_02955	COG4475	Protein of unknown function (DUF436)
HGJ18_02960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGJ18_02980	COG4245	von Willebrand factor, type A
HGJ18_03035	COG0840	transmembrane signaling receptor activity
HGJ18_03040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGJ18_03120	COG0312	modulator of DNA gyrase
HGJ18_03125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGJ18_03130	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGJ18_03140	COG3942	CHAP domain
HGJ18_03140	COG1388	LysM domain
HGJ18_03160	COG0497	DNA recombination
HGJ18_03190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGJ18_03195	COG0312	modulator of DNA gyrase
HGJ18_03205	COG4988	ABC transporter
HGJ18_03210	COG0433	COG0433 Predicted ATPase
HGJ18_03220	COG0768	penicillin binding
HGJ18_03225	COG2604	Protein of unknown function DUF115
HGJ18_03250	COG1739	Uncharacterized protein family UPF0029
HGJ18_03280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGJ18_03290	COG0330	HflC and HflK could
HGJ18_03295	COG0330	HflC and HflK could
HGJ18_03320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGJ18_03325	COG2088	sporulation resulting in formation of a cellular spore
HGJ18_03335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGJ18_03340	COG0037	tRNA processing
HGJ18_03345	COG0457	Tetratricopeptide repeat
HGJ18_03350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_03355	COG0358	DNA primase activity
HGJ18_03360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_03380	COG1077	Cell shape determining protein MreB Mrl
HGJ18_03395	COG0768	penicillin binding
HGJ18_03400	COG0772	Belongs to the SEDS family
HGJ18_03425	COG2252	PERMEase
HGJ18_03435	COG0525	valine-tRNA ligase activity
HGJ18_03445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_03450	COG0346	lactoylglutathione lyase activity
HGJ18_03460	COG0556	nucleotide-excision repair
HGJ18_03465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HGJ18_03465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HGJ18_03470	COG0557	exoribonuclease II activity
HGJ18_03505	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGJ18_03540	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HGJ18_03545	COG0640	Transcriptional regulator
HGJ18_03550	COG2217	Heavy metal translocating P-type atpase
HGJ18_03560	COG0564	pseudouridine synthase activity
HGJ18_03575	COG4656	Part of a membrane complex involved in electron transport
HGJ18_03580	COG4658	electron transport chain
HGJ18_03620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGJ18_03625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGJ18_03625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGJ18_03635	COG0488	(ABC) transporter
HGJ18_03645	COG0047	phosphoribosylformylglycinamidine synthase activity
HGJ18_03655	COG1078	dGTPase activity
HGJ18_03680	COG0475	glutathione-regulated potassium exporter activity
HGJ18_03710	COG0463	Glycosyl transferase, family 2
HGJ18_03725	COG1368	sulfuric ester hydrolase activity
HGJ18_03745	COG1086	Polysaccharide biosynthesis protein
HGJ18_03750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGJ18_03760	COG0562	UDP-galactopyranose mutase
HGJ18_03775	COG1083	cytidylyl-transferase
HGJ18_03780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGJ18_03800	COG2089	acid synthase
HGJ18_03810	COG1215	transferase activity, transferring glycosyl groups
HGJ18_03820	COG0463	Glycosyl transferase, family 2
HGJ18_03820	COG1216	Glycosyl transferase, family 2
HGJ18_03845	COG0438	transferase activity, transferring glycosyl groups
HGJ18_03855	COG0463	Glycosyl transferase, family 2
HGJ18_03865	COG1696	Membrane protein involved in D-alanine export
HGJ18_03890	COG0297	glycogen (starch) synthase activity
HGJ18_03895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGJ18_03905	COG1088	dTDP-glucose 4,6-dehydratase activity
HGJ18_03910	COG0124	histidyl-tRNA synthetase
HGJ18_03920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HGJ18_03935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGJ18_03945	COG1162	GTPase activity
HGJ18_03950	COG1193	negative regulation of DNA recombination
HGJ18_03965	COG2211	Major facilitator Superfamily
HGJ18_03965	COG2190	(PTS) system
HGJ18_04005	COG0009	L-threonylcarbamoyladenylate synthase
HGJ18_04015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGJ18_04025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGJ18_04030	COG3437	response regulator, receiver
HGJ18_04030	COG2770	Histidine kinase
HGJ18_04040	COG0802	atpase or kinase
HGJ18_04055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGJ18_04055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGJ18_04065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGJ18_04070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGJ18_04105	COG0217	transcriptional regulatory protein
HGJ18_04110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGJ18_04125	COG0643	Histidine kinase
HGJ18_04125	COG2198	Histidine kinase
HGJ18_04130	COG0835	chemotaxis
HGJ18_04140	COG2201	protein-glutamate methylesterase activity
HGJ18_04150	COG1196	nuclear chromosome segregation
HGJ18_04160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGJ18_04165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGJ18_04175	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_04175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_04190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGJ18_04195	COG0254	rRNA binding
HGJ18_04205	COG1760	l-serine dehydratase
HGJ18_04210	COG1760	l-serine dehydratase
HGJ18_04220	COG1136	(ABC) transporter
HGJ18_04225	COG0672	)-iron permease
HGJ18_04230	COG3470	protein probably involved in high-affinity Fe2 transport
HGJ18_04245	COG0577	efflux transmembrane transporter activity
HGJ18_04250	COG1136	(ABC) transporter
HGJ18_04280	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HGJ18_04300	COG1692	metallophosphoesterase
HGJ18_04310	COG0142	geranyltranstransferase activity
HGJ18_04315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGJ18_04335	COG0727	PFAM Uncharacterised protein family (UPF0153)
HGJ18_04340	COG1234	tRNA 3'-trailer cleavage
HGJ18_04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGJ18_04370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGJ18_04375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGJ18_04380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGJ18_04385	COG0205	6-phosphofructokinase activity
HGJ18_04390	COG0095	Lipoate-protein ligase
HGJ18_04425	COG4115	mRNA cleavage
HGJ18_04435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGJ18_04440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_04465	COG2982	Protein involved in outer membrane biogenesis
HGJ18_04470	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HGJ18_04475	COG0297	glycogen (starch) synthase activity
HGJ18_04495	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGJ18_04505	COG0835	chemotaxis
HGJ18_04515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGJ18_04520	COG0488	(ABC) transporter
HGJ18_04530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_04530	COG0493	'glutamate synthase
HGJ18_04535	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HGJ18_04550	COG1129	ABC transporter
HGJ18_04555	COG1132	(ABC) transporter
HGJ18_04560	COG1132	(ABC) transporter
HGJ18_04560	COG2375	cellular response to nickel ion
HGJ18_04565	COG1309	transcriptional regulator
HGJ18_04585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGJ18_04605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGJ18_04625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGJ18_04630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGJ18_04635	COG0509	glycine decarboxylation via glycine cleavage system
HGJ18_04640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGJ18_04650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGJ18_04685	COG3052	prosthetic group binding
HGJ18_04690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGJ18_04690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGJ18_04690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGJ18_04695	COG0237	dephospho-CoA kinase activity
HGJ18_04705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGJ18_04710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGJ18_04725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGJ18_04750	COG1122	ATPase activity
HGJ18_04755	COG1268	BioY protein
HGJ18_04760	COG1132	(ABC) transporter
HGJ18_04765	COG1132	(ABC) transporter
HGJ18_04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGJ18_04790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGJ18_04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGJ18_04805	COG0305	Participates in initiation and elongation during chromosome replication
HGJ18_04825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HGJ18_04835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HGJ18_04855	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGJ18_04860	COG0740	serine-type endopeptidase activity
HGJ18_04865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGJ18_04875	COG0359	binds to the 23S rRNA
HGJ18_04880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGJ18_04885	COG0629	single-stranded DNA binding
HGJ18_04890	COG0360	Binds together with S18 to 16S ribosomal RNA
HGJ18_04900	COG1269	ATP hydrolysis coupled proton transport
HGJ18_04905	COG1394	ATPase activity, coupled to movement of substances
HGJ18_04910	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HGJ18_04915	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HGJ18_04920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGJ18_04925	COG2203	Gaf domain
HGJ18_04925	COG3706	GGDEF domain
HGJ18_04925	COG4251	negative regulation of phosphorylation
HGJ18_04925	COG5001	Diguanylate cyclase
HGJ18_04930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGJ18_04935	COG0457	Tetratricopeptide repeat
HGJ18_04945	COG1131	(ABC) transporter
HGJ18_04965	COG0588	phosphoglycerate mutase activity
HGJ18_04990	COG1546	Belongs to the CinA family
HGJ18_04990	COG1058	Belongs to the CinA family
HGJ18_05000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGJ18_05005	COG0776	regulation of translation
HGJ18_05010	COG0268	Binds directly to 16S ribosomal RNA
HGJ18_05030	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGJ18_05035	COG0126	phosphoglycerate kinase activity
HGJ18_05045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGJ18_05050	COG0519	Catalyzes the synthesis of GMP from XMP
HGJ18_05055	COG1846	Transcriptional regulator
HGJ18_05090	COG0617	tRNA 3'-terminal CCA addition
HGJ18_05110	COG3250	beta-galactosidase activity
HGJ18_05120	COG0484	heat shock protein binding
HGJ18_05125	COG0024	Methionine aminopeptidase
HGJ18_05130	COG0708	Exodeoxyribonuclease III
HGJ18_05145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_05155	COG0739	heme binding
HGJ18_05410	COG2059	Chromate
HGJ18_05415	COG0799	negative regulation of ribosome biogenesis
HGJ18_05430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGJ18_05435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGJ18_05445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGJ18_05450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGJ18_05455	COG2033	superoxide reductase activity
HGJ18_05530	COG0484	heat shock protein binding
HGJ18_05665	COG3093	addiction module antidote protein HigA
HGJ18_05790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGJ18_05820	COG1418	mRNA catabolic process
HGJ18_05835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGJ18_05875	COG1196	nuclear chromosome segregation
HGJ18_06050	COG0561	phosphatase activity
HGJ18_06140	COG1136	(ABC) transporter
HGJ18_06140	COG0577	efflux transmembrane transporter activity
HGJ18_06145	COG1136	(ABC) transporter
HGJ18_06165	COG2161	toxin-antitoxin pair type II binding
HGJ18_06185	COG2056	Na+-H+ antiporter family
HGJ18_06220	COG0632	four-way junction helicase activity
HGJ18_06225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGJ18_06260	COG0793	Belongs to the peptidase S41A family
HGJ18_06270	COG0488	(ABC) transporter
HGJ18_06285	COG2723	6-phospho-beta-galactosidase activity
HGJ18_06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_06315	COG1114	Component of the transport system for branched-chain amino acids
HGJ18_06325	COG0481	GTPase activity
HGJ18_06330	COG2878	Part of a membrane complex involved in electron transport
HGJ18_06335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGJ18_06340	COG0138	bifunctional purine biosynthesis protein purh
HGJ18_06345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGJ18_06350	COG0653	protein targeting
HGJ18_06355	COG1725	Transcriptional regulator
HGJ18_06370	COG0736	holo-[acyl-carrier-protein] synthase activity
HGJ18_06385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGJ18_06390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HGJ18_06400	COG2255	four-way junction helicase activity
HGJ18_06405	COG1979	alcohol dehydrogenase
HGJ18_06410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGJ18_06415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HGJ18_06425	COG0731	radical SAM domain protein
HGJ18_06445	COG1047	Peptidyl-prolyl cis-trans
HGJ18_06480	COG0295	cytidine deaminase activity
HGJ18_06525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGJ18_06555	COG1079	Belongs to the binding-protein-dependent transport system permease family
HGJ18_06560	COG4603	Belongs to the binding-protein-dependent transport system permease family
HGJ18_06565	COG3845	ABC transporter
HGJ18_06570	COG1744	ABC transporter substrate-binding protein PnrA-like
HGJ18_06575	COG1234	tRNA 3'-trailer cleavage
HGJ18_06620	COG1283	sodium-dependent phosphate transmembrane transporter activity
HGJ18_06625	COG0475	glutathione-regulated potassium exporter activity
HGJ18_06640	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HGJ18_06645	COG2204	response regulator
HGJ18_06650	COG3852	Histidine kinase
HGJ18_06655	COG0470	DNA polymerase III
HGJ18_06660	COG1286	toxin biosynthetic process
HGJ18_06665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGJ18_06705	COG4254	PFAM FecR protein
HGJ18_06720	COG0823	Involved in the tonB-independent uptake of proteins
HGJ18_06730	COG1199	ATP-dependent helicase activity
HGJ18_06740	COG2885	chlorophyll binding
HGJ18_06750	COG0606	chelatase, subunit chli
HGJ18_06765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGJ18_06770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGJ18_06785	COG0170	dolichyl monophosphate biosynthetic process
HGJ18_06795	COG1233	COG1233 Phytoene dehydrogenase and related
HGJ18_06805	COG1132	(ABC) transporter
HGJ18_06805	COG2375	cellular response to nickel ion
HGJ18_06815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGJ18_06840	COG2885	chlorophyll binding
HGJ18_06845	COG0084	hydrolase, TatD family'
HGJ18_06855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGJ18_06865	COG0438	transferase activity, transferring glycosyl groups
HGJ18_06870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HGJ18_06880	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HGJ18_06885	COG3880	PFAM UvrB UvrC protein
HGJ18_06895	COG1136	(ABC) transporter
HGJ18_06900	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGJ18_06910	COG0552	protein localization to endoplasmic reticulum
HGJ18_06925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HGJ18_06940	COG4166	transmembrane transport
HGJ18_06960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGJ18_07005	COG1918	ferrous iron import across plasma membrane
HGJ18_07005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HGJ18_07010	COG1918	ferrous iron import across plasma membrane
HGJ18_07030	COG1722	exodeoxyribonuclease VII activity
HGJ18_07035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGJ18_07040	COG0251	oxidation-reduction process
HGJ18_07065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGJ18_07070	COG5001	Diguanylate cyclase
HGJ18_07090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HGJ18_07095	COG2204	response regulator
HGJ18_07100	COG0539	negative regulation of cytoplasmic translation
HGJ18_07115	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HGJ18_07120	COG0528	UMP kinase activity
HGJ18_07125	COG0484	heat shock protein binding
HGJ18_07130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGJ18_07135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGJ18_07140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGJ18_07145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGJ18_07165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGJ18_07170	COG3876	Protein conserved in bacteria
HGJ18_07185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGJ18_07195	COG0513	Belongs to the DEAD box helicase family
HGJ18_07200	COG0284	orotidine-5'-phosphate decarboxylase activity
HGJ18_07220	COG1131	(ABC) transporter
HGJ18_07245	COG1126	abc transporter atp-binding protein
HGJ18_07255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGJ18_07280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGJ18_07320	COG1122	ATPase activity
HGJ18_07350	COG1770	oligopeptidase
HGJ18_07355	COG4953	penicillin-binding protein 1C
HGJ18_07360	COG3681	Belongs to the UPF0597 family
HGJ18_07385	COG0741	lytic transglycosylase activity
HGJ18_07385	COG1388	LysM domain
HGJ18_07395	COG1671	Belongs to the UPF0178 family
HGJ18_07400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HGJ18_07410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGJ18_07415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGJ18_07430	COG1129	ABC transporter
HGJ18_07440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGJ18_07445	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HGJ18_07445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGJ18_07450	COG2738	Putative neutral zinc metallopeptidase
HGJ18_07465	COG2226	methyltransferase
HGJ18_07485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGJ18_07505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGJ18_07510	COG0671	phosphoesterase, PA-phosphatase related
HGJ18_07535	COG1022	Amp-dependent synthetase and ligase
HGJ18_07540	COG1475	DNA binding
HGJ18_07550	COG0739	heme binding
HGJ18_07555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGJ18_07555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HGJ18_07565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGJ18_07575	COG0156	8-amino-7-oxononanoate synthase activity
HGJ18_07585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGJ18_07585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGJ18_07585	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGJ18_07585	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGJ18_07590	COG0626	cystathionine gamma-synthase activity
HGJ18_07600	COG1757	Na H antiporter
HGJ18_07605	COG2056	Na+-H+ antiporter family
HGJ18_07625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGJ18_07645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_07665	COG2226	methyltransferase
HGJ18_07670	COG4211	Belongs to the binding-protein-dependent transport system permease family
HGJ18_07675	COG1129	ABC transporter
HGJ18_07680	COG1879	ABC-type sugar transport system periplasmic component
HGJ18_07695	COG0442	prolyl-tRNA aminoacylation
HGJ18_07715	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGJ18_07725	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGJ18_07730	COG1120	ATPase activity
HGJ18_07735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGJ18_07750	COG4865	methylaspartate mutase activity
HGJ18_07770	COG3142	Participates in the control of copper homeostasis
HGJ18_07785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGJ18_07805	COG3657	addiction module killer protein
HGJ18_07825	COG0737	Belongs to the 5'-nucleotidase family
HGJ18_07830	COG0826	peptidase U32
HGJ18_07835	COG0657	acetylesterase activity
HGJ18_07840	COG1132	(ABC) transporter
HGJ18_07850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGJ18_07865	COG0101	tRNA pseudouridine synthase activity
HGJ18_07875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGJ18_07880	COG1639	'signal transduction protein
HGJ18_07895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGJ18_07900	COG1136	(ABC) transporter
HGJ18_07900	COG0577	efflux transmembrane transporter activity
HGJ18_07920	COG3956	TIGRFAM MazG family protein
HGJ18_07925	COG0545	Peptidyl-prolyl cis-trans isomerase
HGJ18_07930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGJ18_07935	COG1329	Transcriptional regulator
HGJ18_07940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGJ18_07940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGJ18_07945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGJ18_07960	COG0668	transmembrane transport
HGJ18_07975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_07980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGJ18_07985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGJ18_08000	COG0792	nuclease activity
HGJ18_08015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGJ18_08035	COG3604	Transcriptional regulator
HGJ18_08045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGJ18_08060	COG1272	protein, Hemolysin III
HGJ18_08065	COG0739	heme binding
HGJ18_08065	COG0741	lytic transglycosylase activity
HGJ18_08065	COG1196	nuclear chromosome segregation
HGJ18_08090	COG0668	transmembrane transport
HGJ18_08095	COG2197	response regulator
HGJ18_08130	COG0542	response to heat
HGJ18_08135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HGJ18_08140	COG2949	membrane
HGJ18_08145	COG0210	DNA helicase
HGJ18_08150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HGJ18_08160	COG0495	leucyl-tRNA aminoacylation
HGJ18_08170	COG0750	zinc metalloprotease
HGJ18_08175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGJ18_08180	COG0575	Belongs to the CDS family
HGJ18_08185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGJ18_08190	COG0233	cytoplasmic translational termination
HGJ18_08195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGJ18_08200	COG0052	Belongs to the universal ribosomal protein uS2 family
HGJ18_08205	COG0424	maF-like protein
HGJ18_08210	COG1413	lyase activity
HGJ18_08235	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HGJ18_08240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGJ18_08250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGJ18_08255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGJ18_08260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGJ18_08275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGJ18_08295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGJ18_08300	COG1131	(ABC) transporter
HGJ18_08315	COG4585	Histidine kinase
HGJ18_08325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HGJ18_08335	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGJ18_08350	COG0740	serine-type endopeptidase activity
HGJ18_08365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGJ18_08375	COG1847	R3H domain protein
HGJ18_08380	COG0706	membrane insertase activity
HGJ18_08385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGJ18_08395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HGJ18_08405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGJ18_08415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGJ18_08445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGJ18_08460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HGJ18_08465	COG0058	SHG alpha-glucan phosphorylase activity
HGJ18_08500	COG4172	Belongs to the ABC transporter superfamily
HGJ18_08505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_08510	COG0601	transmembrane transport
HGJ18_08515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGJ18_08520	COG0085	RNA polymerase activity
HGJ18_08525	COG0222	ribosome binding
HGJ18_08530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGJ18_08535	COG0081	regulation of translation
HGJ18_08540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGJ18_08545	COG0250	Participates in transcription elongation, termination and antitermination
HGJ18_08550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGJ18_08560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGJ18_08620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGJ18_08625	COG1363	Peptidase, m42
HGJ18_08630	COG2274	protein secretion by the type I secretion system
HGJ18_08635	COG0281	malic enzyme
HGJ18_08650	COG3885	ferrous iron binding
HGJ18_08650	COG2078	PFAM AMMECR1 domain protein
HGJ18_08655	COG0666	response to abiotic stimulus
HGJ18_08660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGJ18_08665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGJ18_08685	COG0425	Belongs to the sulfur carrier protein TusA family
HGJ18_08700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGJ18_08710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HGJ18_08720	COG0534	Mate efflux family protein
HGJ18_08725	COG0549	Belongs to the carbamate kinase family
HGJ18_08730	COG1921	L-seryl-tRNASec selenium transferase activity
HGJ18_08735	COG0322	excinuclease ABC activity
HGJ18_08745	COG0326	Molecular chaperone. Has ATPase activity
HGJ18_08780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGJ18_08785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGJ18_08790	COG1573	uracil-dna glycosylase
HGJ18_08835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGJ18_08860	COG1132	(ABC) transporter
HGJ18_08865	COG1132	(ABC) transporter
HGJ18_08870	COG1012	belongs to the aldehyde dehydrogenase family
HGJ18_08875	COG0357	Ribosomal RNA small subunit methyltransferase G
HGJ18_08885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGJ18_08895	COG1132	(ABC) transporter
HGJ18_08910	COG2604	Protein of unknown function DUF115
HGJ18_08925	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGJ18_08960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGJ18_09010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGJ18_09030	COG1132	(ABC) transporter
HGJ18_09035	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HGJ18_09040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGJ18_09060	COG1132	(ABC) transporter
HGJ18_09065	COG4988	ABC transporter
HGJ18_09075	COG1121	(ABC) transporter
HGJ18_09080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGJ18_09105	COG0301	tRNA thio-modification
HGJ18_09110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGJ18_09115	COG0328	RNA-DNA hybrid ribonuclease activity
HGJ18_09120	COG4443	Transcriptional Coactivator p15 (PC4)
HGJ18_09125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_09135	COG0166	Belongs to the GPI family
HGJ18_09140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGJ18_09150	COG0564	pseudouridine synthase activity
HGJ18_09165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGJ18_09170	COG3706	GGDEF domain
HGJ18_09195	COG3290	protein histidine kinase activity
HGJ18_09195	COG0840	transmembrane signaling receptor activity
HGJ18_09200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGJ18_09215	COG1362	aminopeptidase activity
HGJ18_09220	COG1054	Belongs to the UPF0176 family
HGJ18_09225	COG0724	RNA recognition motif
HGJ18_09250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGJ18_09260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGJ18_09270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGJ18_09280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGJ18_09290	COG3314	Sporulation integral membrane protein YlbJ
HGJ18_09295	COG0406	alpha-ribazole phosphatase activity
HGJ18_09300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGJ18_09315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGJ18_09335	COG1477	protein flavinylation
HGJ18_09340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGJ18_09345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGJ18_09360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGJ18_09385	COG1132	(ABC) transporter
HGJ18_09390	COG2375	cellular response to nickel ion
HGJ18_09390	COG1132	(ABC) transporter
HGJ18_09420	COG3177	Filamentation induced by cAMP protein fic
HGJ18_09435	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_09445	COG4175	Glycine betaine
HGJ18_09445	COG0517	IMP dehydrogenase activity
HGJ18_09455	COG2205	protein histidine kinase activity
HGJ18_09460	COG1136	(ABC) transporter
HGJ18_09470	COG0095	Lipoate-protein ligase
HGJ18_09475	COG1132	(ABC) transporter
HGJ18_09500	COG1131	(ABC) transporter
HGJ18_09525	COG1797	cobyrinic acid a,c-diamide synthase activity
HGJ18_09530	COG0784	Response regulator, receiver
HGJ18_09530	COG3437	response regulator, receiver
HGJ18_09550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGJ18_09555	COG0516	GMP reductase activity
HGJ18_09565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGJ18_09570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGJ18_09575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGJ18_09605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGJ18_09640	COG1191	sigma factor activity
HGJ18_09655	COG1419	protein localization to endoplasmic reticulum
HGJ18_09660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGJ18_09670	COG0504	CTP synthase activity
HGJ18_09685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGJ18_09685	COG1747	RNA polymerase binding
HGJ18_09695	COG0674	pyruvate-flavodoxin oxidoreductase activity
HGJ18_09695	COG1013	pyruvate-flavodoxin oxidoreductase activity
HGJ18_09695	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HGJ18_09695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HGJ18_09700	COG2885	chlorophyll binding
HGJ18_09735	COG2378	regulation of single-species biofilm formation
HGJ18_09750	COG1136	(ABC) transporter
HGJ18_09755	COG5002	protein histidine kinase activity
HGJ18_09765	COG1473	amidohydrolase
HGJ18_09780	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HGJ18_09800	COG2201	protein-glutamate methylesterase activity
HGJ18_09820	COG1137	ATPase activity
HGJ18_09825	COG0193	aminoacyl-tRNA hydrolase activity
HGJ18_09835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGJ18_09845	COG0601	transmembrane transport
HGJ18_09850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGJ18_09855	COG0444	Belongs to the ABC transporter superfamily
HGJ18_09860	COG4608	Belongs to the ABC transporter superfamily
HGJ18_09865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGJ18_09890	COG0484	heat shock protein binding
HGJ18_09895	COG0443	Heat shock 70 kDa protein
HGJ18_09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGJ18_09925	COG1120	ATPase activity
HGJ18_09950	COG0534	Mate efflux family protein
HGJ18_09960	COG0840	transmembrane signaling receptor activity
HGJ18_09995	COG1192	Involved in chromosome partitioning
HGJ18_10000	COG1475	DNA binding
HGJ18_10020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGJ18_10025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGJ18_10040	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_10055	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGJ18_10080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGJ18_10085	COG0825	malonyl-CoA metabolic process
HGJ18_10090	COG2986	histidine ammonia-lyase
HGJ18_10105	COG0701	Predicted permease
HGJ18_10110	COG3689	TIGRFAM TIGR03943 family protein
HGJ18_10115	COG0714	Associated with various cellular activities
HGJ18_10150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGJ18_10155	COG0154	amidase activity
HGJ18_10160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGJ18_10230	COG1136	(ABC) transporter
HGJ18_10285	COG1028	Short-chain dehydrogenase reductase Sdr
HGJ18_10345	COG3041	Addiction module toxin RelE StbE family
HGJ18_10380	COG3850	Histidine kinase
HGJ18_10380	COG5002	protein histidine kinase activity
HGJ18_10385	COG0745	RESPONSE REGULATOR receiver
HGJ18_10410	COG4555	ABC transporter
HGJ18_10445	COG1151	hydroxylamine reductase activity
HGJ18_10460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HGJ18_10465	COG1136	(ABC) transporter
HGJ18_10465	COG0577	efflux transmembrane transporter activity
HGJ18_10485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGJ18_10525	COG0813	purine-nucleoside phosphorylase activity
HGJ18_10545	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HGJ18_10550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGJ18_10570	COG2235	arginine
HGJ18_10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGJ18_10580	COG1528	Iron-storage protein
HGJ18_10585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGJ18_10605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HGJ18_10625	COG0515	serine threonine protein kinase
HGJ18_10650	COG0343	queuine tRNA-ribosyltransferase activity
HGJ18_10660	COG1381	Involved in DNA repair and RecF pathway recombination
HGJ18_10665	COG0514	ATP-dependent DNA helicase (RecQ)
HGJ18_10670	COG1592	Rubrerythrin
HGJ18_10680	COG1652	LysM domain
HGJ18_10680	COG2823	Periplasmic or secreted lipoprotein
HGJ18_10725	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HGJ18_10730	COG0501	Belongs to the peptidase M48B family
HGJ18_10740	COG0543	2 iron, 2 sulfur cluster binding
HGJ18_10770	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HGJ18_10785	COG1136	(ABC) transporter
HGJ18_10800	COG1116	anion transmembrane transporter activity
HGJ18_10805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGJ18_10810	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HGJ18_10830	COG1653	transport
HGJ18_10835	COG0395	ABC-type sugar transport system, permease component
HGJ18_10840	COG1175	transmembrane transport
HGJ18_10845	COG3842	ATPase activity
HGJ18_10850	COG1840	ABC-type Fe3 transport system, periplasmic component
HGJ18_10855	COG4133	protoheme IX ABC transporter activity
HGJ18_10895	COG3842	ATPase activity
HGJ18_10900	COG0438	transferase activity, transferring glycosyl groups
HGJ18_10910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGJ18_10930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGJ18_10940	COG1132	(ABC) transporter
HGJ18_10955	COG0786	glutamate:sodium symporter activity
HGJ18_10960	COG1132	(ABC) transporter
HGJ18_10965	COG1132	(ABC) transporter
HGJ18_10990	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGJ18_11005	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGJ18_11030	COG0698	ribose 5-phosphate isomerase
HGJ18_11035	COG0039	L-malate dehydrogenase activity
HGJ18_11040	COG0534	Mate efflux family protein
HGJ18_11045	COG0574	Belongs to the PEP-utilizing enzyme family
HGJ18_11045	COG3848	Pyruvate phosphate dikinase
HGJ18_11050	COG1309	transcriptional regulator
HGJ18_11055	COG0840	transmembrane signaling receptor activity
HGJ18_11065	COG0728	peptidoglycan biosynthetic process
HGJ18_11105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGJ18_11110	COG3588	fructose-bisphosphate aldolase
HGJ18_11115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGJ18_11120	COG1132	(ABC) transporter
HGJ18_11125	COG1132	(ABC) transporter
HGJ18_11135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGJ18_11145	COG0569	domain protein
HGJ18_11150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGJ18_11170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGJ18_11180	COG3177	Filamentation induced by cAMP protein fic
HGJ18_11190	COG0012	GTP binding
HGJ18_11195	COG0616	signal peptide processing
HGJ18_11210	COG1136	(ABC) transporter
HGJ18_11225	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HGJ18_11230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGJ18_11235	COG0569	domain protein
HGJ18_11260	COG0714	Associated with various cellular activities
HGJ18_11265	COG4536	flavin adenine dinucleotide binding
HGJ18_11270	COG4536	flavin adenine dinucleotide binding
HGJ18_11285	COG0514	ATP-dependent DNA helicase (RecQ)
HGJ18_11295	COG1518	maintenance of DNA repeat elements
HGJ18_11300	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HGJ18_11310	COG1309	transcriptional regulator
HGJ18_11315	COG0534	Mate efflux family protein
HGJ18_11325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGJ18_11330	COG0628	permease
HGJ18_11335	COG0363	glucosamine-6-phosphate deaminase activity
HGJ18_11345	COG1309	transcriptional regulator
HGJ18_11360	COG1129	ABC transporter
HGJ18_11390	COG1132	(ABC) transporter
HGJ18_11390	COG2375	cellular response to nickel ion
HGJ18_11395	COG1132	(ABC) transporter
HGJ18_11445	COG2226	methyltransferase
HGJ18_11460	COG1129	ABC transporter
HGJ18_11490	COG3189	MarR family transcriptional regulator
HGJ18_11495	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HGJ18_11500	COG1309	transcriptional regulator
HGJ18_11505	COG1132	(ABC) transporter
HGJ18_11510	COG1132	(ABC) transporter
HGJ18_11515	COG1129	ABC transporter
HGJ18_11540	COG3118	belongs to the thioredoxin family
HGJ18_11545	COG1418	mRNA catabolic process
HGJ18_11605	COG0592	DNA-directed DNA polymerase activity
HGJ18_11610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGJ18_11765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGJ18_11780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HGJ18_11800	COG1929	Belongs to the glycerate kinase type-1 family
HGJ18_11805	COG2610	gluconate transmembrane transporter activity
HGJ18_11820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGJ18_11835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGJ18_11855	COG2337	Toxic component of a toxin-antitoxin (TA) module
HGJ18_11885	COG2184	nucleotidyltransferase activity
HGJ18_11895	COG0730	response to heat
HGJ18_11915	COG4208	sulfate ABC transporter
HGJ18_11930	COG0840	transmembrane signaling receptor activity
HGJ18_11945	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HGJ18_11950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGJ18_11955	COG1674	ftsk spoiiie
HGJ18_11960	COG1968	undecaprenyl-diphosphatase activity
HGJ18_11965	COG0419	ATPase involved in DNA repair
HGJ18_11970	COG0420	3'-5' exonuclease activity
HGJ18_11975	COG0840	transmembrane signaling receptor activity
HGJ18_11975	COG3290	protein histidine kinase activity
HGJ18_11985	COG1131	(ABC) transporter
HGJ18_12005	COG0716	FMN binding
HGJ18_12025	COG1401	restriction endodeoxyribonuclease activity
HGJ18_12045	COG0800	Aldolase
HGJ18_12070	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_12095	COG4585	Histidine kinase
HGJ18_12100	COG1473	amidohydrolase
HGJ18_12120	COG1373	ATPase (AAA superfamily
HGJ18_12135	COG4143	(ABC) transporter
HGJ18_12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGJ18_12160	COG1070	Carbohydrate kinase
HGJ18_12170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGJ18_12180	COG2186	Transcriptional regulator
HGJ18_12190	COG1823	symporter activity
HGJ18_12195	COG0540	Belongs to the ATCase OTCase family
HGJ18_12195	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HGJ18_12200	COG5001	Diguanylate cyclase
HGJ18_12200	COG5002	protein histidine kinase activity
HGJ18_12250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGJ18_12270	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HGJ18_12285	COG1774	PSP1 C-terminal conserved region
HGJ18_12290	COG1728	Protein conserved in bacteria
HGJ18_12300	COG0739	heme binding
HGJ18_12320	COG0366	Alpha amylase catalytic
HGJ18_12330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGJ18_12335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGJ18_12340	COG1104	cysteine desulfurase activity
HGJ18_12355	COG4946	Tricorn protease homolog
HGJ18_12355	COG0823	Involved in the tonB-independent uptake of proteins
HGJ18_12355	COG1506	peptidase
HGJ18_12385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGJ18_12390	COG0215	cysteine-tRNA ligase activity
HGJ18_12405	COG1305	Transglutaminase-like
HGJ18_12410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGJ18_12415	COG0569	domain protein
HGJ18_12420	COG2887	Belongs to the helicase family. UvrD subfamily
HGJ18_12425	COG1074	ATP-dependent DNA helicase activity
HGJ18_12445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGJ18_12465	COG0840	transmembrane signaling receptor activity
HGJ18_12470	COG0826	peptidase U32
HGJ18_12475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGJ18_12480	COG1509	lysine 2,3-aminomutase activity
HGJ18_12485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGJ18_12490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGJ18_12505	COG0205	6-phosphofructokinase activity
HGJ18_12540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGJ18_12550	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGJ18_12555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGJ18_12560	COG1684	flagellar biosynthetic protein fliR
HGJ18_12565	COG1987	bacterial-type flagellum assembly
HGJ18_12590	COG1228	amidohydrolase
HGJ18_12605	COG0457	Tetratricopeptide repeat
HGJ18_12610	COG0280	phosphate acetyltransferase
HGJ18_12620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGJ18_12625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGJ18_12645	COG1401	restriction endodeoxyribonuclease activity
HGJ18_12690	COG1132	(ABC) transporter
HGJ18_12720	COG1472	Belongs to the glycosyl hydrolase 3 family
HGJ18_12740	COG0423	glycine-tRNA ligase activity
HGJ18_12745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HGJ18_12755	COG1363	Peptidase, m42
HGJ18_12760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGJ18_12775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGJ18_12780	COG1966	Carbon starvation protein
HGJ18_12785	COG0450	alkyl hydroperoxide reductase
HGJ18_12790	COG0494	nUDIX hydrolase
HGJ18_12800	COG2217	Heavy metal translocating P-type atpase
HGJ18_12810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGJ18_12830	COG0187	DNA topoisomerase II activity