locus-tag	class	description
HO345_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HO345_00015	COG0587	DNA-directed DNA polymerase activity
HO345_00045	COG2986	histidine ammonia-lyase
HO345_00050	COG0825	malonyl-CoA metabolic process
HO345_00055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HO345_00060	COG0439	Biotin carboxylase
HO345_00080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HO345_00095	COG1028	Short-chain dehydrogenase reductase Sdr
HO345_00100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HO345_00105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HO345_00125	COG1475	DNA binding
HO345_00130	COG1192	Involved in chromosome partitioning
HO345_00160	COG0840	transmembrane signaling receptor activity
HO345_00170	COG0534	Mate efflux family protein
HO345_00185	COG0396	ATPase activity
HO345_00190	COG0719	Fe-S assembly protein
HO345_00200	COG0674	pyruvate-flavodoxin oxidoreductase activity
HO345_00200	COG1013	pyruvate-flavodoxin oxidoreductase activity
HO345_00200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HO345_00200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HO345_00205	COG4172	Belongs to the ABC transporter superfamily
HO345_00210	COG0444	Belongs to the ABC transporter superfamily
HO345_00215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_00225	COG4166	transmembrane transport
HO345_00235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HO345_00235	COG1747	RNA polymerase binding
HO345_00250	COG0504	CTP synthase activity
HO345_00265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HO345_00270	COG1419	protein localization to endoplasmic reticulum
HO345_00285	COG1191	sigma factor activity
HO345_00320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HO345_00350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HO345_00355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HO345_00365	COG0516	GMP reductase activity
HO345_00370	COG2211	Major facilitator Superfamily
HO345_00430	COG1120	ATPase activity
HO345_00455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HO345_00460	COG0443	Heat shock 70 kDa protein
HO345_00465	COG0484	heat shock protein binding
HO345_00490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HO345_00495	COG4608	Belongs to the ABC transporter superfamily
HO345_00500	COG0444	Belongs to the ABC transporter superfamily
HO345_00505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_00510	COG0601	transmembrane transport
HO345_00520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HO345_00530	COG0193	aminoacyl-tRNA hydrolase activity
HO345_00535	COG1137	ATPase activity
HO345_00555	COG2201	protein-glutamate methylesterase activity
HO345_00575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HO345_00590	COG1473	amidohydrolase
HO345_00600	COG5002	protein histidine kinase activity
HO345_00605	COG1136	(ABC) transporter
HO345_00625	COG2378	regulation of single-species biofilm formation
HO345_00650	COG2885	chlorophyll binding
HO345_00655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HO345_00665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO345_00675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HO345_00685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HO345_00715	COG3118	belongs to the thioredoxin family
HO345_00725	COG1120	ATPase activity
HO345_00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_00745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HO345_00745	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HO345_00750	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HO345_00765	COG1757	Na H antiporter
HO345_00770	COG1120	ATPase activity
HO345_00775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_00785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HO345_00790	COG0051	transcription antitermination factor activity, RNA binding
HO345_00795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HO345_00800	COG0088	Forms part of the polypeptide exit tunnel
HO345_00805	COG0089	rRNA binding
HO345_00810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HO345_00815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HO345_00820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HO345_00825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HO345_00830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HO345_00835	COG0255	Belongs to the universal ribosomal protein uL29 family
HO345_00840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HO345_00845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HO345_00850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HO345_00855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HO345_00860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HO345_00865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HO345_00870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HO345_00875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HO345_00880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HO345_00885	COG1841	ribosomal large subunit assembly
HO345_00890	COG0200	Binds to the 23S rRNA
HO345_00900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HO345_00905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HO345_00910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HO345_00915	COG0202	RNA polymerase activity
HO345_00920	COG0203	ribosomal protein L17
HO345_00945	COG1254	Belongs to the acylphosphatase family
HO345_00970	COG2226	methyltransferase
HO345_00975	COG1959	2 iron, 2 sulfur cluster binding
HO345_00980	COG2910	NAD(P)H-binding
HO345_01005	COG1401	restriction endodeoxyribonuclease activity
HO345_01040	COG0840	transmembrane signaling receptor activity
HO345_01050	COG1132	(ABC) transporter
HO345_01075	COG1132	(ABC) transporter
HO345_01125	COG1132	(ABC) transporter
HO345_01135	COG1129	ABC transporter
HO345_01150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HO345_01160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HO345_01165	COG0445	tRNA wobble uridine modification
HO345_01170	COG1362	aminopeptidase activity
HO345_01190	COG4657	Part of a membrane complex involved in electron transport
HO345_01195	COG4660	Part of a membrane complex involved in electron transport
HO345_01200	COG4659	FMN binding
HO345_01205	COG4658	electron transport chain
HO345_01210	COG4656	Part of a membrane complex involved in electron transport
HO345_01220	COG2304	oxidoreductase activity
HO345_01235	COG0574	Belongs to the PEP-utilizing enzyme family
HO345_01235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO345_01245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HO345_01270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HO345_01280	COG2137	regulation of response to DNA damage stimulus
HO345_01285	COG2197	response regulator
HO345_01310	COG1187	pseudouridine synthase activity
HO345_01315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HO345_01330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HO345_01375	COG0326	Molecular chaperone. Has ATPase activity
HO345_01390	COG1285	pathogenesis
HO345_01395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HO345_01425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HO345_01430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HO345_01435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HO345_01465	COG0357	Ribosomal RNA small subunit methyltransferase G
HO345_01470	COG1012	belongs to the aldehyde dehydrogenase family
HO345_01475	COG1132	(ABC) transporter
HO345_01480	COG1132	(ABC) transporter
HO345_01500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HO345_01535	COG0840	transmembrane signaling receptor activity
HO345_01545	COG1573	uracil-dna glycosylase
HO345_01550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HO345_01570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HO345_01615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HO345_01630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HO345_01645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HO345_01660	COG2604	Protein of unknown function DUF115
HO345_01690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HO345_01715	COG0322	excinuclease ABC activity
HO345_01725	COG1921	L-seryl-tRNASec selenium transferase activity
HO345_01730	COG0549	Belongs to the carbamate kinase family
HO345_01735	COG0534	Mate efflux family protein
HO345_01740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO345_01745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HO345_01755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO345_01760	COG0765	amino acid transport
HO345_01770	COG1126	abc transporter atp-binding protein
HO345_01775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HO345_01790	COG0425	Belongs to the sulfur carrier protein TusA family
HO345_01810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HO345_01825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HO345_01830	COG0666	response to abiotic stimulus
HO345_01835	COG3885	ferrous iron binding
HO345_01835	COG2078	PFAM AMMECR1 domain protein
HO345_01850	COG0281	malic enzyme
HO345_01860	COG1363	Peptidase, m42
HO345_01865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HO345_01895	COG1652	LysM domain
HO345_01925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HO345_01935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HO345_01940	COG0250	Participates in transcription elongation, termination and antitermination
HO345_01945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HO345_01950	COG0081	regulation of translation
HO345_01955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HO345_01960	COG0222	ribosome binding
HO345_01965	COG0085	RNA polymerase activity
HO345_01970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HO345_01975	COG0601	transmembrane transport
HO345_01980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_01985	COG4172	Belongs to the ABC transporter superfamily
HO345_02030	COG0058	SHG alpha-glucan phosphorylase activity
HO345_02035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HO345_02050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HO345_02070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HO345_02080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HO345_02085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HO345_02095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HO345_02100	COG0706	membrane insertase activity
HO345_02105	COG1847	R3H domain protein
HO345_02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HO345_02125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HO345_02130	COG0740	serine-type endopeptidase activity
HO345_02145	COG1181	Belongs to the D-alanine--D-alanine ligase family
HO345_02155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HO345_02165	COG4585	Histidine kinase
HO345_02180	COG1131	(ABC) transporter
HO345_02185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HO345_02205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HO345_02225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HO345_02230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HO345_02235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_02245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HO345_02250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HO345_02255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HO345_02285	COG1413	lyase activity
HO345_02290	COG0424	maF-like protein
HO345_02295	COG0052	Belongs to the universal ribosomal protein uS2 family
HO345_02300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HO345_02305	COG0233	cytoplasmic translational termination
HO345_02310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HO345_02315	COG0575	Belongs to the CDS family
HO345_02320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HO345_02325	COG0750	zinc metalloprotease
HO345_02335	COG0495	leucyl-tRNA aminoacylation
HO345_02345	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HO345_02350	COG1132	(ABC) transporter
HO345_02355	COG1132	(ABC) transporter
HO345_02360	COG0210	DNA helicase
HO345_02365	COG2949	membrane
HO345_02390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HO345_02395	COG0542	response to heat
HO345_02420	COG2197	response regulator
HO345_02425	COG0668	transmembrane transport
HO345_02450	COG1196	nuclear chromosome segregation
HO345_02450	COG0741	lytic transglycosylase activity
HO345_02450	COG0739	heme binding
HO345_02455	COG1272	protein, Hemolysin III
HO345_02475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HO345_02480	COG0598	Magnesium transport protein CorA
HO345_02510	COG0196	riboflavin kinase activity
HO345_02515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HO345_02520	COG1185	polyribonucleotide nucleotidyltransferase activity
HO345_02525	COG0756	dUTP diphosphatase activity
HO345_02540	COG2832	Protein of unknown function (DUF454)
HO345_02550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HO345_02555	COG0049	tRNA binding
HO345_02560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HO345_02585	COG0840	transmembrane signaling receptor activity
HO345_02590	COG0534	Mate efflux family protein
HO345_02605	COG0577	efflux transmembrane transporter activity
HO345_02605	COG1136	(ABC) transporter
HO345_02610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HO345_02615	COG2195	Cleaves the N-terminal amino acid of tripeptides
HO345_02625	COG0803	Belongs to the bacterial solute-binding protein 9 family
HO345_02645	COG0442	prolyl-tRNA aminoacylation
HO345_02660	COG1879	ABC-type sugar transport system periplasmic component
HO345_02665	COG1129	ABC transporter
HO345_02670	COG4211	Belongs to the binding-protein-dependent transport system permease family
HO345_02675	COG2226	methyltransferase
HO345_02685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HO345_02705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HO345_02710	COG2056	Na+-H+ antiporter family
HO345_02725	COG0626	cystathionine gamma-synthase activity
HO345_02730	COG1013	pyruvate-flavodoxin oxidoreductase activity
HO345_02730	COG0674	pyruvate-flavodoxin oxidoreductase activity
HO345_02730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO345_02730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HO345_02745	COG0564	pseudouridine synthase activity
HO345_02750	COG0156	8-amino-7-oxononanoate synthase activity
HO345_02760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HO345_02770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HO345_02770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HO345_02775	COG0739	heme binding
HO345_02785	COG1475	DNA binding
HO345_02790	COG1022	Amp-dependent synthetase and ligase
HO345_02815	COG0671	phosphoesterase, PA-phosphatase related
HO345_02820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HO345_02845	COG2226	methyltransferase
HO345_02865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HO345_02875	COG2738	Putative neutral zinc metallopeptidase
HO345_02885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HO345_02895	COG1129	ABC transporter
HO345_02910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HO345_02915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HO345_02925	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HO345_02930	COG1671	Belongs to the UPF0178 family
HO345_02940	COG0741	lytic transglycosylase activity
HO345_02940	COG1388	LysM domain
HO345_02960	COG3681	Belongs to the UPF0597 family
HO345_02965	COG4953	penicillin-binding protein 1C
HO345_02970	COG1770	oligopeptidase
HO345_03000	COG1122	ATPase activity
HO345_03050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HO345_03060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HO345_03105	COG1131	(ABC) transporter
HO345_03125	COG0284	orotidine-5'-phosphate decarboxylase activity
HO345_03130	COG0513	Belongs to the DEAD box helicase family
HO345_03140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HO345_03150	COG3876	Protein conserved in bacteria
HO345_03155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HO345_03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO345_03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HO345_03175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HO345_03180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HO345_03190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HO345_03195	COG0484	heat shock protein binding
HO345_03200	COG0528	UMP kinase activity
HO345_03205	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HO345_03220	COG0539	negative regulation of cytoplasmic translation
HO345_03225	COG2204	response regulator
HO345_03230	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HO345_03250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HO345_03275	COG0251	oxidation-reduction process
HO345_03280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HO345_03285	COG1722	exodeoxyribonuclease VII activity
HO345_03305	COG1918	ferrous iron import across plasma membrane
HO345_03310	COG1918	ferrous iron import across plasma membrane
HO345_03310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HO345_03355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HO345_03375	COG4166	transmembrane transport
HO345_03390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HO345_03405	COG0552	protein localization to endoplasmic reticulum
HO345_03415	COG4591	ABC-type transport system involved in lipoprotein release permease component
HO345_03420	COG1136	(ABC) transporter
HO345_03430	COG3880	PFAM UvrB UvrC protein
HO345_03435	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HO345_03445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HO345_03450	COG0438	transferase activity, transferring glycosyl groups
HO345_03460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HO345_03470	COG0084	hydrolase, TatD family'
HO345_03475	COG2885	chlorophyll binding
HO345_03550	COG0697	spore germination
HO345_03585	COG2375	cellular response to nickel ion
HO345_03585	COG1132	(ABC) transporter
HO345_03595	COG1309	transcriptional regulator
HO345_03605	COG1164	Oligoendopeptidase f
HO345_03610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HO345_03615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HO345_03620	COG0606	chelatase, subunit chli
HO345_03630	COG2885	chlorophyll binding
HO345_03640	COG1199	ATP-dependent helicase activity
HO345_03650	COG0823	Involved in the tonB-independent uptake of proteins
HO345_03665	COG4254	PFAM FecR protein
HO345_03700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HO345_03705	COG1286	toxin biosynthetic process
HO345_03710	COG0470	DNA polymerase III
HO345_03715	COG3852	Histidine kinase
HO345_03720	COG2204	response regulator
HO345_03725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HO345_03740	COG0475	glutathione-regulated potassium exporter activity
HO345_03745	COG1283	sodium-dependent phosphate transmembrane transporter activity
HO345_03820	COG1234	tRNA 3'-trailer cleavage
HO345_03825	COG1744	ABC transporter substrate-binding protein PnrA-like
HO345_03830	COG3845	ABC transporter
HO345_03835	COG4603	Belongs to the binding-protein-dependent transport system permease family
HO345_03840	COG1079	Belongs to the binding-protein-dependent transport system permease family
HO345_03870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HO345_03920	COG0295	cytidine deaminase activity
HO345_03955	COG1047	Peptidyl-prolyl cis-trans
HO345_03970	COG0731	radical SAM domain protein
HO345_03985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HO345_03990	COG1979	alcohol dehydrogenase
HO345_03995	COG2255	four-way junction helicase activity
HO345_04010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HO345_04015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HO345_04030	COG0736	holo-[acyl-carrier-protein] synthase activity
HO345_04050	COG0653	protein targeting
HO345_04060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HO345_04065	COG0138	bifunctional purine biosynthesis protein purh
HO345_04070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HO345_04075	COG2878	Part of a membrane complex involved in electron transport
HO345_04080	COG0481	GTPase activity
HO345_04090	COG1114	Component of the transport system for branched-chain amino acids
HO345_04105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HO345_04125	COG3657	addiction module killer protein
HO345_04130	COG2723	6-phospho-beta-galactosidase activity
HO345_04145	COG0488	(ABC) transporter
HO345_04155	COG0793	Belongs to the peptidase S41A family
HO345_04190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HO345_04195	COG0632	four-way junction helicase activity
HO345_04255	COG2361	Protein of unknown function DUF86
HO345_04275	COG1136	(ABC) transporter
HO345_04405	COG2361	Protein of unknown function DUF86
HO345_04635	COG2337	Toxic component of a toxin-antitoxin (TA) module
HO345_04670	COG2801	Transposase and inactivated derivatives
HO345_04710	COG2226	methyltransferase
HO345_04720	COG0406	alpha-ribazole phosphatase activity
HO345_04730	COG1418	mRNA catabolic process
HO345_04745	COG2033	superoxide reductase activity
HO345_04750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HO345_04755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HO345_04765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HO345_04770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HO345_04785	COG0799	negative regulation of ribosome biogenesis
HO345_04790	COG2059	Chromate
HO345_04835	COG0739	heme binding
HO345_04845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO345_04855	COG0708	Exodeoxyribonuclease III
HO345_04860	COG0024	Methionine aminopeptidase
HO345_04875	COG1233	COG1233 Phytoene dehydrogenase and related
HO345_04880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HO345_04880	COG1017	nitric oxide dioxygenase activity
HO345_04900	COG0617	tRNA 3'-terminal CCA addition
HO345_04935	COG1846	Transcriptional regulator
HO345_04940	COG0519	Catalyzes the synthesis of GMP from XMP
HO345_04945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HO345_04955	COG0126	phosphoglycerate kinase activity
HO345_04960	COG0860	N-Acetylmuramoyl-L-alanine amidase
HO345_04980	COG0268	Binds directly to 16S ribosomal RNA
HO345_04985	COG0776	regulation of translation
HO345_04990	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HO345_05000	COG1546	Belongs to the CinA family
HO345_05000	COG1058	Belongs to the CinA family
HO345_05030	COG0588	phosphoglycerate mutase activity
HO345_05055	COG1131	(ABC) transporter
HO345_05065	COG0457	Tetratricopeptide repeat
HO345_05070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HO345_05075	COG5001	Diguanylate cyclase
HO345_05075	COG4251	negative regulation of phosphorylation
HO345_05075	COG3706	GGDEF domain
HO345_05075	COG2203	Gaf domain
HO345_05080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HO345_05085	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HO345_05090	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HO345_05095	COG1394	ATPase activity, coupled to movement of substances
HO345_05100	COG1269	ATP hydrolysis coupled proton transport
HO345_05110	COG0360	Binds together with S18 to 16S ribosomal RNA
HO345_05115	COG0629	single-stranded DNA binding
HO345_05120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HO345_05125	COG0359	binds to the 23S rRNA
HO345_05135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HO345_05140	COG0740	serine-type endopeptidase activity
HO345_05145	COG0544	peptidyl-prolyl cis-trans isomerase activity
HO345_05160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HO345_05180	COG0305	Participates in initiation and elongation during chromosome replication
HO345_05190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HO345_05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HO345_05200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HO345_05235	COG1268	BioY protein
HO345_05240	COG1122	ATPase activity
HO345_05245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HO345_05255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HO345_05270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HO345_05275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HO345_05285	COG0237	dephospho-CoA kinase activity
HO345_05290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HO345_05290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HO345_05290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HO345_05310	COG3052	prosthetic group binding
HO345_05330	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HO345_05340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HO345_05350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HO345_05355	COG0509	glycine decarboxylation via glycine cleavage system
HO345_05360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HO345_05365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HO345_05380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HO345_05400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HO345_05420	COG2226	methyltransferase
HO345_05430	COG1061	Type III restriction enzyme res subunit
HO345_05460	COG1129	ABC transporter
HO345_05465	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HO345_05470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HO345_05470	COG0493	'glutamate synthase
HO345_05480	COG0488	(ABC) transporter
HO345_05485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HO345_05495	COG0835	chemotaxis
HO345_05510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HO345_05530	COG0297	glycogen (starch) synthase activity
HO345_05535	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HO345_05540	COG2982	Protein involved in outer membrane biogenesis
HO345_05565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HO345_05570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HO345_05685	COG0095	Lipoate-protein ligase
HO345_05690	COG4608	Belongs to the ABC transporter superfamily
HO345_05695	COG0444	Belongs to the ABC transporter superfamily
HO345_05700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_05705	COG0601	transmembrane transport
HO345_05710	COG0747	negative chemotaxis
HO345_05715	COG0205	6-phosphofructokinase activity
HO345_05720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HO345_05725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HO345_05730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HO345_05750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HO345_05765	COG0727	PFAM Uncharacterised protein family (UPF0153)
HO345_05785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HO345_05795	COG0142	geranyltranstransferase activity
HO345_05805	COG1692	metallophosphoesterase
HO345_05840	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HO345_05875	COG1136	(ABC) transporter
HO345_05880	COG0577	efflux transmembrane transporter activity
HO345_05895	COG3470	protein probably involved in high-affinity Fe2 transport
HO345_05900	COG0672	)-iron permease
HO345_05905	COG1132	(ABC) transporter
HO345_05910	COG1136	(ABC) transporter
HO345_05920	COG1760	l-serine dehydratase
HO345_05925	COG1760	l-serine dehydratase
HO345_05935	COG0254	rRNA binding
HO345_05940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HO345_05955	COG0574	Belongs to the PEP-utilizing enzyme family
HO345_05955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO345_05965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HO345_05975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HO345_05985	COG1196	nuclear chromosome segregation
HO345_05995	COG2201	protein-glutamate methylesterase activity
HO345_06005	COG0835	chemotaxis
HO345_06010	COG0643	Histidine kinase
HO345_06010	COG2198	Histidine kinase
HO345_06025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HO345_06030	COG0217	transcriptional regulatory protein
HO345_06065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HO345_06070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HO345_06080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HO345_06080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HO345_06095	COG0802	atpase or kinase
HO345_06105	COG3437	response regulator, receiver
HO345_06110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HO345_06115	COG0681	Belongs to the peptidase S26 family
HO345_06120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HO345_06130	COG0009	L-threonylcarbamoyladenylate synthase
HO345_06165	COG2190	(PTS) system
HO345_06165	COG2211	Major facilitator Superfamily
HO345_06180	COG1193	negative regulation of DNA recombination
HO345_06185	COG1162	GTPase activity
HO345_06195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HO345_06210	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HO345_06220	COG0124	histidyl-tRNA synthetase
HO345_06235	COG0438	transferase activity, transferring glycosyl groups
HO345_06270	COG0463	Glycosyl transferase, family 2
HO345_06275	COG3306	glycosyltransferase involved in LPS biosynthesis
HO345_06280	COG0463	Glycosyl transferase, family 2
HO345_06320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HO345_06320	COG1215	transferase activity, transferring glycosyl groups
HO345_06325	COG1215	transferase activity, transferring glycosyl groups
HO345_06340	COG1215	transferase activity, transferring glycosyl groups
HO345_06345	COG1215	transferase activity, transferring glycosyl groups
HO345_06355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HO345_06415	COG0475	glutathione-regulated potassium exporter activity
HO345_06440	COG1078	dGTPase activity
HO345_06450	COG0047	phosphoribosylformylglycinamidine synthase activity
HO345_06460	COG0488	(ABC) transporter
HO345_06470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HO345_06470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HO345_06475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HO345_06520	COG4656	Part of a membrane complex involved in electron transport
HO345_06535	COG0564	pseudouridine synthase activity
HO345_06545	COG2217	Heavy metal translocating P-type atpase
HO345_06550	COG0640	Transcriptional regulator
HO345_06555	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HO345_06580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HO345_06605	COG0557	exoribonuclease II activity
HO345_06610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HO345_06610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HO345_06615	COG0556	nucleotide-excision repair
HO345_06625	COG1129	ABC transporter
HO345_06650	COG1129	ABC transporter
HO345_06665	COG1132	(ABC) transporter
HO345_06670	COG1132	(ABC) transporter
HO345_06670	COG2375	cellular response to nickel ion
HO345_06675	COG2207	Transcriptional regulator
HO345_06685	COG4555	ABC transporter
HO345_06695	COG2378	regulation of single-species biofilm formation
HO345_06700	COG0525	valine-tRNA ligase activity
HO345_06710	COG2252	PERMEase
HO345_06735	COG0772	Belongs to the SEDS family
HO345_06740	COG0768	penicillin binding
HO345_06755	COG1077	Cell shape determining protein MreB Mrl
HO345_06775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO345_06780	COG0358	DNA primase activity
HO345_06795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO345_06800	COG0457	Tetratricopeptide repeat
HO345_06805	COG0037	tRNA processing
HO345_06810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HO345_06820	COG2088	sporulation resulting in formation of a cellular spore
HO345_06825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HO345_06845	COG0330	HflC and HflK could
HO345_06850	COG0330	HflC and HflK could
HO345_06860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HO345_06885	COG1739	Uncharacterized protein family UPF0029
HO345_06890	COG0658	competence protein
HO345_06890	COG2333	competence protein COMEC
HO345_06910	COG2604	Protein of unknown function DUF115
HO345_06915	COG0768	penicillin binding
HO345_06925	COG0433	COG0433 Predicted ATPase
HO345_06935	COG0312	modulator of DNA gyrase
HO345_06960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HO345_06980	COG0497	DNA recombination
HO345_07000	COG1388	LysM domain
HO345_07000	COG0791	NLP P60 protein
HO345_07010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HO345_07015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO345_07020	COG0312	modulator of DNA gyrase
HO345_07045	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HO345_07050	COG0840	transmembrane signaling receptor activity
HO345_07080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HO345_07085	COG4475	Protein of unknown function (DUF436)
HO345_07125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HO345_07130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HO345_07135	COG3118	belongs to the thioredoxin family
HO345_07150	COG4750	Nucleotidyl transferase
HO345_07155	COG1115	amino acid carrier protein
HO345_07180	COG1193	negative regulation of DNA recombination
HO345_07230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HO345_07235	COG1480	7TM receptor with intracellular HD hydrolase
HO345_07240	COG1702	phosphate starvation-inducible protein PhoH
HO345_07255	COG0149	triose-phosphate isomerase activity
HO345_07265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HO345_07285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HO345_07300	COG0803	Belongs to the bacterial solute-binding protein 9 family
HO345_07305	COG1121	(ABC) transporter
HO345_07310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HO345_07315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HO345_07340	COG1157	protein secretion by the type III secretion system
HO345_07345	COG1317	bacterial-type flagellum organization
HO345_07355	COG1766	The M ring may be actively involved in energy transduction
HO345_07360	COG1677	Flagellar hook-basal body complex protein FliE
HO345_07375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HO345_07380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HO345_07385	COG4974	Belongs to the 'phage' integrase family
HO345_07390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HO345_07390	COG0551	DNA topoisomerase type I activity
HO345_07395	COG0758	DNA mediated transformation
HO345_07405	COG4974	Belongs to the 'phage' integrase family
HO345_07410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HO345_07420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HO345_07425	COG0772	Belongs to the SEDS family
HO345_07430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HO345_07440	COG0275	rRNA processing
HO345_07445	COG2001	Belongs to the MraZ family
HO345_07450	COG1505	serine-type exopeptidase activity
HO345_07485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HO345_07495	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HO345_07515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_07520	COG1120	ATPase activity
HO345_07530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HO345_07535	COG0459	protein refolding
HO345_07550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HO345_07555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HO345_07595	COG1366	Belongs to the anti-sigma-factor antagonist family
HO345_07615	COG3033	Beta-eliminating lyase
HO345_07645	COG0563	adenylate kinase activity
HO345_07665	COG0779	Required for maturation of 30S ribosomal subunits
HO345_07675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HO345_07680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HO345_07685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HO345_07695	COG0840	transmembrane signaling receptor activity
HO345_07730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HO345_07735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HO345_07745	COG3330	Domain of unknown function (DUF4912)
HO345_07760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HO345_07770	COG3706	GGDEF domain
HO345_07775	COG1102	Psort location Cytoplasmic, score
HO345_07780	COG1561	YicC-like family, N-terminal region
HO345_07795	COG0564	pseudouridine synthase activity
HO345_07810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HO345_07815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HO345_07820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HO345_07820	COG0426	domain, Protein
HO345_07830	COG0601	transmembrane transport
HO345_07835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_07840	COG0444	Belongs to the ABC transporter superfamily
HO345_07845	COG4608	Belongs to the ABC transporter superfamily
HO345_07855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HO345_07855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HO345_07885	COG3956	TIGRFAM MazG family protein
HO345_07890	COG0545	Peptidyl-prolyl cis-trans isomerase
HO345_07895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HO345_07905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HO345_07905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HO345_07910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HO345_07925	COG0668	transmembrane transport
HO345_07940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HO345_07945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HO345_07950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO345_07965	COG0792	nuclease activity
HO345_07980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HO345_08000	COG3604	Transcriptional regulator
HO345_08025	COG0737	Belongs to the 5'-nucleotidase family
HO345_08055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HO345_08075	COG3142	Participates in the control of copper homeostasis
HO345_08120	COG0826	peptidase U32
HO345_08125	COG0657	acetylesterase activity
HO345_08130	COG1132	(ABC) transporter
HO345_08135	COG0840	transmembrane signaling receptor activity
HO345_08140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HO345_08155	COG0101	tRNA pseudouridine synthase activity
HO345_08165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HO345_08170	COG1639	'signal transduction protein
HO345_08185	COG1120	ATPase activity
HO345_08190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_08205	COG4865	methylaspartate mutase activity
HO345_08220	COG0617	tRNA 3'-terminal CCA addition
HO345_08230	COG0071	Belongs to the small heat shock protein (HSP20) family
HO345_08235	COG0571	ribonuclease III activity
HO345_08240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HO345_08245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HO345_08255	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HO345_08275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HO345_08275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HO345_08290	COG1067	ATP-dependent peptidase activity
HO345_08300	COG2703	oxygen carrier activity
HO345_08305	COG2183	response to ionizing radiation
HO345_08315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HO345_08325	COG3951	Flagellar rod assembly protein muramidase FlgJ
HO345_08335	COG4786	Flagellar basal body rod
HO345_08355	COG2084	Dehydrogenase
HO345_08360	COG2116	formate transmembrane transporter activity
HO345_08370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HO345_08390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HO345_08400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HO345_08410	COG4608	Belongs to the ABC transporter superfamily
HO345_08415	COG0444	Belongs to the ABC transporter superfamily
HO345_08425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_08430	COG0601	transmembrane transport
HO345_08450	COG0017	Asparaginyl-tRNA synthetase
HO345_08455	COG1686	Belongs to the peptidase S11 family
HO345_08460	COG2003	Belongs to the UPF0758 family
HO345_08465	COG1040	competence protein
HO345_08470	COG0018	arginyl-trna synthetase
HO345_08475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HO345_08485	COG0084	hydrolase, TatD family'
HO345_08490	COG1692	metallophosphoesterase
HO345_08500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HO345_08510	COG0484	heat shock protein binding
HO345_08515	COG2089	acid synthase
HO345_08520	COG5341	Protein conserved in bacteria
HO345_08525	COG1752	Esterase of the alpha-beta hydrolase superfamily
HO345_08530	COG0584	glycerophosphoryl diester phosphodiesterase
HO345_08535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HO345_08540	COG1704	LemA family
HO345_08545	COG1079	Belongs to the binding-protein-dependent transport system permease family
HO345_08550	COG4603	Belongs to the binding-protein-dependent transport system permease family
HO345_08555	COG3845	ABC transporter
HO345_08560	COG1744	ABC transporter substrate-binding protein PnrA-like
HO345_08590	COG0148	phosphopyruvate hydratase activity
HO345_08595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HO345_08605	COG0318	PFAM AMP-dependent synthetase and ligase
HO345_08610	COG0791	NLP P60 protein
HO345_08620	COG3735	TraB family
HO345_08625	COG0116	Belongs to the methyltransferase superfamily
HO345_08630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO345_08635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HO345_08640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HO345_08645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HO345_08655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HO345_08665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HO345_08670	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HO345_08685	COG2195	Cleaves the N-terminal amino acid of tripeptides
HO345_08705	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HO345_08715	COG1132	(ABC) transporter
HO345_08720	COG1132	(ABC) transporter
HO345_08730	COG1129	ABC transporter
HO345_08740	COG0210	DNA helicase
HO345_08770	COG0335	large ribosomal subunit rRNA binding
HO345_08775	COG0336	Belongs to the RNA methyltransferase TrmD family
HO345_08780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HO345_08785	COG1837	Belongs to the UPF0109 family
HO345_08790	COG0228	four-way junction DNA binding
HO345_08810	COG0577	efflux transmembrane transporter activity
HO345_08810	COG1136	(ABC) transporter
HO345_08815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HO345_08845	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HO345_08850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HO345_08860	COG1132	(ABC) transporter
HO345_08865	COG4988	ABC transporter
HO345_08870	COG1121	(ABC) transporter
HO345_08875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HO345_08900	COG0301	tRNA thio-modification
HO345_08905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HO345_08910	COG0328	RNA-DNA hybrid ribonuclease activity
HO345_08915	COG4443	Transcriptional Coactivator p15 (PC4)
HO345_08920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HO345_08930	COG0166	Belongs to the GPI family
HO345_08935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HO345_08945	COG0564	pseudouridine synthase activity
HO345_08950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HO345_08960	COG3706	GGDEF domain
HO345_08980	COG0840	transmembrane signaling receptor activity
HO345_08985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HO345_09000	COG1362	aminopeptidase activity
HO345_09005	COG1054	Belongs to the UPF0176 family
HO345_09010	COG0724	RNA recognition motif
HO345_09055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HO345_09070	COG1266	CAAX protease self-immunity
HO345_09100	COG1086	Polysaccharide biosynthesis protein
HO345_09145	COG0330	HflC and HflK could
HO345_09165	COG1131	(ABC) transporter
HO345_09195	COG1131	(ABC) transporter
HO345_09200	COG0351	phosphomethylpyrimidine kinase
HO345_09210	COG0482	sulfurtransferase activity
HO345_09225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HO345_09230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HO345_09235	COG1028	Short-chain dehydrogenase reductase Sdr
HO345_09240	COG0629	single-stranded DNA binding
HO345_09245	COG1862	Preprotein translocase
HO345_09250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HO345_09255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HO345_09260	COG1104	cysteine desulfurase activity
HO345_09270	COG0425	Belongs to the sulfur carrier protein TusA family
HO345_09310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HO345_09325	COG3314	Sporulation integral membrane protein YlbJ
HO345_09335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HO345_09350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HO345_09370	COG1477	protein flavinylation
HO345_09375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HO345_09380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HO345_09395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HO345_09400	COG0346	lactoylglutathione lyase activity
HO345_09420	COG1132	(ABC) transporter
HO345_09425	COG1132	(ABC) transporter
HO345_09425	COG2375	cellular response to nickel ion
HO345_09455	COG3177	Filamentation induced by cAMP protein fic
HO345_09465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HO345_09465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HO345_09470	COG0446	pyridine nucleotide-disulphide oxidoreductase
HO345_09480	COG3448	diguanylate cyclase activity
HO345_09480	COG4175	Glycine betaine
HO345_09485	COG0095	Lipoate-protein ligase
HO345_09495	COG1131	(ABC) transporter
HO345_09500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HO345_09505	COG1122	ATPase activity
HO345_09540	COG1797	cobyrinic acid a,c-diamide synthase activity
HO345_09545	COG2770	Histidine kinase
HO345_09545	COG3437	response regulator, receiver
HO345_09565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HO345_09605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HO345_09610	COG0546	phosphoglycolate phosphatase activity
HO345_09620	COG2239	Acts as a magnesium transporter
HO345_09635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HO345_09645	COG1309	transcriptional regulator
HO345_09650	COG1132	(ABC) transporter
HO345_09655	COG1132	(ABC) transporter
HO345_09660	COG1132	(ABC) transporter
HO345_09695	COG1132	(ABC) transporter
HO345_09700	COG1129	ABC transporter
HO345_09720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HO345_09730	COG2199	diguanylate cyclase activity
HO345_09730	COG2203	Gaf domain
HO345_09740	COG0084	hydrolase, TatD family'
HO345_09745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HO345_09745	COG3116	cell division
HO345_09765	COG4974	Belongs to the 'phage' integrase family
HO345_09785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HO345_09800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HO345_09815	COG4545	Glutaredoxin-related protein
HO345_09820	COG1196	nuclear chromosome segregation
HO345_09820	COG0741	lytic transglycosylase activity
HO345_09820	COG0739	heme binding
HO345_09825	COG2423	ornithine cyclodeaminase activity
HO345_09830	COG4166	transmembrane transport
HO345_09900	COG1338	Plays a role in the flagellum-specific transport system
HO345_09910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HO345_09910	COG1776	CheC inhibitor of MCP methylation
HO345_09915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HO345_09920	COG1580	Controls the rotational direction of flagella during chemotaxis
HO345_09925	COG1360	Flagellar Motor Protein
HO345_09930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HO345_09945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HO345_09965	COG1132	(ABC) transporter
HO345_09980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HO345_09985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HO345_10005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HO345_10010	COG1120	ATPase activity
HO345_10015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HO345_10055	COG1132	(ABC) transporter
HO345_10060	COG1132	(ABC) transporter
HO345_10070	COG0701	Predicted permease
HO345_10075	COG3689	TIGRFAM TIGR03943 family protein
HO345_10080	COG0714	Associated with various cellular activities
HO345_10115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HO345_10120	COG0154	amidase activity
HO345_10125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HO345_10215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HO345_10285	COG1136	(ABC) transporter
HO345_10485	COG1396	sequence-specific DNA binding
HO345_10495	COG3550	peptidyl-serine autophosphorylation
HO345_10520	COG4555	ABC transporter
HO345_10535	COG0840	transmembrane signaling receptor activity
HO345_10555	COG1151	hydroxylamine reductase activity
HO345_10570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HO345_10575	COG0577	efflux transmembrane transporter activity
HO345_10575	COG1136	(ABC) transporter
HO345_10595	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HO345_10600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HO345_10615	COG2235	arginine
HO345_10620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HO345_10635	COG4555	ABC transporter
HO345_10645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HO345_10885	COG0343	queuine tRNA-ribosyltransferase activity
HO345_10895	COG1381	Involved in DNA repair and RecF pathway recombination
HO345_10905	COG0514	ATP-dependent DNA helicase (RecQ)
HO345_10910	COG1592	Rubrerythrin
HO345_10940	COG2274	protein secretion by the type I secretion system
HO345_10975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HO345_10980	COG0501	Belongs to the peptidase M48B family
HO345_10990	COG0543	2 iron, 2 sulfur cluster binding
HO345_11030	COG1074	ATP-dependent DNA helicase activity
HO345_11035	COG2887	Belongs to the helicase family. UvrD subfamily
HO345_11040	COG0569	domain protein
HO345_11045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HO345_11050	COG1305	Transglutaminase-like
HO345_11065	COG0215	cysteine-tRNA ligase activity
HO345_11070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HO345_11085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HO345_11100	COG0823	Involved in the tonB-independent uptake of proteins
HO345_11100	COG4946	Tricorn protease homolog
HO345_11100	COG1506	peptidase
HO345_11125	COG1104	cysteine desulfurase activity
HO345_11130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HO345_11135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HO345_11160	COG1609	Transcriptional regulator
HO345_11170	COG0366	Alpha amylase catalytic
HO345_11190	COG0739	heme binding
HO345_11200	COG1728	Protein conserved in bacteria
HO345_11205	COG1774	PSP1 C-terminal conserved region
HO345_11220	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HO345_11240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HO345_11300	COG5001	Diguanylate cyclase
HO345_11300	COG5002	protein histidine kinase activity
HO345_11305	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HO345_11305	COG0540	Belongs to the ATCase OTCase family
HO345_11320	COG0446	pyridine nucleotide-disulphide oxidoreductase
HO345_11330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HO345_11345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HO345_11350	COG4143	(ABC) transporter
HO345_11360	COG3842	ATPase activity
HO345_11365	COG1373	ATPase (AAA superfamily
HO345_11375	COG1473	amidohydrolase
HO345_11380	COG4585	Histidine kinase
HO345_11385	COG2197	response regulator
HO345_11395	COG0446	pyridine nucleotide-disulphide oxidoreductase
HO345_11420	COG0800	Aldolase
HO345_11455	COG0716	FMN binding
HO345_11475	COG1131	(ABC) transporter
HO345_11485	COG3290	protein histidine kinase activity
HO345_11485	COG0840	transmembrane signaling receptor activity
HO345_11490	COG0420	3'-5' exonuclease activity
HO345_11495	COG0419	ATPase involved in DNA repair
HO345_11500	COG1968	undecaprenyl-diphosphatase activity
HO345_11505	COG1674	ftsk spoiiie
HO345_11510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HO345_11520	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HO345_11540	COG3839	Belongs to the ABC transporter superfamily
HO345_11545	COG4208	sulfate ABC transporter
HO345_11565	COG0730	response to heat
HO345_11580	COG2184	nucleotidyltransferase activity
HO345_11620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HO345_11635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HO345_11650	COG2610	gluconate transmembrane transporter activity
HO345_11655	COG1929	Belongs to the glycerate kinase type-1 family
HO345_11660	COG3152	Membrane
HO345_11665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HO345_11690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HO345_11700	COG4166	transmembrane transport
HO345_11705	COG0601	transmembrane transport
HO345_11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HO345_11715	COG0444	Belongs to the ABC transporter superfamily
HO345_11720	COG4608	Belongs to the ABC transporter superfamily
HO345_11785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HO345_11875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HO345_11880	COG0592	DNA-directed DNA polymerase activity
HO345_11885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HO345_11890	COG3177	Filamentation induced by cAMP protein fic
HO345_11930	COG1418	mRNA catabolic process
HO345_11940	COG1175	transmembrane transport
HO345_11945	COG3833	ABC-type maltose transport systems, permease component
HO345_11950	COG3842	ATPase activity
HO345_11960	COG3118	belongs to the thioredoxin family
HO345_12000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HO345_12005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HO345_12010	COG0569	domain protein
HO345_12020	COG1132	(ABC) transporter
HO345_12035	COG0714	Associated with various cellular activities
HO345_12040	COG4536	flavin adenine dinucleotide binding
HO345_12045	COG4536	flavin adenine dinucleotide binding
HO345_12070	COG0514	ATP-dependent DNA helicase (RecQ)
HO345_12075	COG1309	transcriptional regulator
HO345_12080	COG0534	Mate efflux family protein
HO345_12090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO345_12095	COG0628	permease
HO345_12100	COG0363	glucosamine-6-phosphate deaminase activity
HO345_12135	COG2375	cellular response to nickel ion
HO345_12135	COG1132	(ABC) transporter
HO345_12140	COG1132	(ABC) transporter
HO345_12180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HO345_12195	COG1129	ABC transporter
HO345_12210	COG0616	signal peptide processing
HO345_12215	COG0012	GTP binding
HO345_12235	COG3706	GGDEF domain
HO345_12240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HO345_12255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HO345_12260	COG0569	domain protein
HO345_12270	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HO345_12285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HO345_12300	COG3588	fructose-bisphosphate aldolase
HO345_12305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HO345_12310	COG0728	peptidoglycan biosynthetic process
HO345_12315	COG0840	transmembrane signaling receptor activity
HO345_12325	COG1309	transcriptional regulator
HO345_12330	COG0574	Belongs to the PEP-utilizing enzyme family
HO345_12330	COG3848	Pyruvate phosphate dikinase
HO345_12335	COG0534	Mate efflux family protein
HO345_12340	COG0039	L-malate dehydrogenase activity
HO345_12345	COG0698	ribose 5-phosphate isomerase
HO345_12360	COG2249	NAD(P)H dehydrogenase (quinone) activity
HO345_12375	COG1132	(ABC) transporter
HO345_12380	COG1132	(ABC) transporter
HO345_12385	COG0786	glutamate:sodium symporter activity
HO345_12400	COG1132	(ABC) transporter
HO345_12430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HO345_12450	COG2274	protein secretion by the type I secretion system
HO345_12450	COG3271	cysteine-type peptidase activity
HO345_12460	COG0438	transferase activity, transferring glycosyl groups
HO345_12465	COG3842	ATPase activity
HO345_12515	COG1840	ABC-type Fe3 transport system, periplasmic component
HO345_12520	COG1924	4 iron, 4 sulfur cluster binding
HO345_12530	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HO345_12545	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HO345_12555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HO345_12575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HO345_12595	COG0840	transmembrane signaling receptor activity
HO345_12600	COG0826	peptidase U32
HO345_12605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HO345_12610	COG1509	lysine 2,3-aminomutase activity
HO345_12615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HO345_12620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HO345_12635	COG0205	6-phosphofructokinase activity
HO345_12680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HO345_12690	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HO345_12695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HO345_12700	COG1684	flagellar biosynthetic protein fliR
HO345_12705	COG1987	bacterial-type flagellum assembly
HO345_12725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HO345_12730	COG0813	purine-nucleoside phosphorylase activity
HO345_12765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HO345_12795	COG1228	amidohydrolase
HO345_12805	COG0457	Tetratricopeptide repeat
HO345_12810	COG0280	phosphate acetyltransferase
HO345_12820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HO345_12830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HO345_12875	COG0537	adenosine 5'-monophosphoramidase activity
HO345_12940	COG1472	Belongs to the glycosyl hydrolase 3 family
HO345_12960	COG0423	glycine-tRNA ligase activity
HO345_12965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HO345_12990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HO345_12995	COG1966	Carbon starvation protein
HO345_13000	COG0450	alkyl hydroperoxide reductase
HO345_13005	COG0494	nUDIX hydrolase
HO345_13015	COG2217	Heavy metal translocating P-type atpase
HO345_13025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HO345_13045	COG0187	DNA topoisomerase II activity