locus-tag	class	description
E4N91_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N91_00015	COG0587	DNA-directed DNA polymerase activity
E4N91_00040	COG0840	transmembrane signaling receptor activity
E4N91_00045	COG1132	(ABC) transporter
E4N91_00050	COG1132	(ABC) transporter
E4N91_00090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N91_00105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N91_00110	COG1360	Flagellar Motor Protein
E4N91_00115	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N91_00120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N91_00125	COG1776	CheC inhibitor of MCP methylation
E4N91_00125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N91_00135	COG1338	Plays a role in the flagellum-specific transport system
E4N91_00150	COG4166	transmembrane transport
E4N91_00155	COG2423	ornithine cyclodeaminase activity
E4N91_00160	COG0739	heme binding
E4N91_00165	COG4545	Glutaredoxin-related protein
E4N91_00180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N91_00205	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4N91_00220	COG0732	type I restriction modification DNA specificity domain
E4N91_00225	COG0732	type I restriction modification DNA specificity domain
E4N91_00230	COG4974	Belongs to the 'phage' integrase family
E4N91_00260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N91_00260	COG3116	cell division
E4N91_00265	COG0084	hydrolase, TatD family'
E4N91_00280	COG2203	Gaf domain
E4N91_00280	COG2199	diguanylate cyclase activity
E4N91_00290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N91_00305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N91_00315	COG2239	Acts as a magnesium transporter
E4N91_00325	COG0546	phosphoglycolate phosphatase activity
E4N91_00345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N91_00380	COG2211	Major facilitator Superfamily
E4N91_00410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N91_00410	COG1747	RNA polymerase binding
E4N91_00425	COG0504	CTP synthase activity
E4N91_00435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N91_00440	COG1419	protein localization to endoplasmic reticulum
E4N91_00455	COG1191	sigma factor activity
E4N91_00490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N91_00520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N91_00525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N91_00530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N91_00540	COG0516	GMP reductase activity
E4N91_00545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N91_00565	COG0784	Response regulator, receiver
E4N91_00565	COG3437	response regulator, receiver
E4N91_00570	COG1797	cobyrinic acid a,c-diamide synthase activity
E4N91_00600	COG1122	ATPase activity
E4N91_00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N91_00620	COG1132	(ABC) transporter
E4N91_00625	COG0095	Lipoate-protein ligase
E4N91_00630	COG0517	IMP dehydrogenase activity
E4N91_00630	COG4175	Glycine betaine
E4N91_00640	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N91_00655	COG3177	Filamentation induced by cAMP protein fic
E4N91_00705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_00715	COG0747	negative chemotaxis
E4N91_00725	COG1132	(ABC) transporter
E4N91_00725	COG2375	cellular response to nickel ion
E4N91_00745	COG1129	ABC transporter
E4N91_00750	COG0346	lactoylglutathione lyase activity
E4N91_00755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N91_00770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N91_00775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N91_00780	COG1477	protein flavinylation
E4N91_00800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N91_00815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N91_00820	COG0406	alpha-ribazole phosphatase activity
E4N91_00830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N91_00840	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N91_00850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N91_00860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N91_00885	COG0724	RNA recognition motif
E4N91_00890	COG1054	Belongs to the UPF0176 family
E4N91_00895	COG1362	aminopeptidase activity
E4N91_00910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N91_00915	COG3290	protein histidine kinase activity
E4N91_00915	COG0840	transmembrane signaling receptor activity
E4N91_00935	COG3706	GGDEF domain
E4N91_00940	COG3706	GGDEF domain
E4N91_00945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N91_00960	COG1121	(ABC) transporter
E4N91_00965	COG0564	pseudouridine synthase activity
E4N91_00975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N91_00980	COG0166	Belongs to the GPI family
E4N91_00990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N91_00995	COG4443	Transcriptional Coactivator p15 (PC4)
E4N91_01000	COG0328	RNA-DNA hybrid ribonuclease activity
E4N91_01005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N91_01010	COG0301	tRNA thio-modification
E4N91_01040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N91_01045	COG1121	(ABC) transporter
E4N91_01055	COG4988	ABC transporter
E4N91_01060	COG1132	(ABC) transporter
E4N91_01075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N91_01080	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N91_01085	COG1132	(ABC) transporter
E4N91_01105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N91_01155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N91_01190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N91_01205	COG2604	Protein of unknown function DUF115
E4N91_01215	COG1132	(ABC) transporter
E4N91_01225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N91_01240	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N91_01245	COG1012	belongs to the aldehyde dehydrogenase family
E4N91_01250	COG1132	(ABC) transporter
E4N91_01255	COG1132	(ABC) transporter
E4N91_01280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N91_01315	COG0840	transmembrane signaling receptor activity
E4N91_01330	COG1573	uracil-dna glycosylase
E4N91_01335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N91_01340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N91_01380	COG0326	Molecular chaperone. Has ATPase activity
E4N91_01390	COG0322	excinuclease ABC activity
E4N91_01395	COG1921	L-seryl-tRNASec selenium transferase activity
E4N91_01405	COG0549	Belongs to the carbamate kinase family
E4N91_01420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N91_01430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N91_01435	COG0765	amino acid transport
E4N91_01445	COG1126	abc transporter atp-binding protein
E4N91_01450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N91_01465	COG0425	Belongs to the sulfur carrier protein TusA family
E4N91_01485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N91_01515	COG2801	Transposase and inactivated derivatives
E4N91_01540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4N91_01565	COG3451	type IV secretory pathway VirB4
E4N91_01590	COG2948	multi-organism process
E4N91_01625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N91_01640	COG2003	Belongs to the UPF0758 family
E4N91_01685	COG0629	single-stranded DNA binding
E4N91_01775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N91_01780	COG0666	response to abiotic stimulus
E4N91_01785	COG2078	PFAM AMMECR1 domain protein
E4N91_01785	COG3885	ferrous iron binding
E4N91_01800	COG0281	malic enzyme
E4N91_01820	COG2274	protein secretion by the type I secretion system
E4N91_01825	COG1363	Peptidase, m42
E4N91_01830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4N91_01890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N91_01900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N91_01905	COG0250	Participates in transcription elongation, termination and antitermination
E4N91_01910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N91_01915	COG0081	regulation of translation
E4N91_01920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N91_01925	COG0222	ribosome binding
E4N91_01930	COG0085	RNA polymerase activity
E4N91_01935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N91_01990	COG0058	SHG alpha-glucan phosphorylase activity
E4N91_02010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N91_02030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N91_02060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N91_02070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N91_02075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N91_02085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N91_02090	COG0706	membrane insertase activity
E4N91_02095	COG1847	R3H domain protein
E4N91_02105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N91_02115	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4N91_02120	COG0740	serine-type endopeptidase activity
E4N91_02135	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N91_02145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N91_02155	COG4585	Histidine kinase
E4N91_02170	COG1131	(ABC) transporter
E4N91_02175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N91_02195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N91_02210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N91_02215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N91_02255	COG2376	Dihydroxyacetone kinase
E4N91_02260	COG2376	Dihydroxyacetone kinase
E4N91_02270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N91_02280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N91_02285	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N91_02310	COG1413	lyase activity
E4N91_02315	COG0424	maF-like protein
E4N91_02320	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N91_02325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N91_02330	COG0233	cytoplasmic translational termination
E4N91_02335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N91_02340	COG0575	Belongs to the CDS family
E4N91_02345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N91_02350	COG0750	zinc metalloprotease
E4N91_02360	COG0495	leucyl-tRNA aminoacylation
E4N91_02370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N91_02375	COG0210	DNA helicase
E4N91_02380	COG2949	membrane
E4N91_02405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N91_02410	COG0542	response to heat
E4N91_02425	COG2197	response regulator
E4N91_02430	COG0668	transmembrane transport
E4N91_02455	COG0739	heme binding
E4N91_02455	COG0741	lytic transglycosylase activity
E4N91_02455	COG1196	nuclear chromosome segregation
E4N91_02460	COG1272	protein, Hemolysin III
E4N91_02475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N91_02490	COG3604	Transcriptional regulator
E4N91_02510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N91_02525	COG0792	nuclease activity
E4N91_02540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N91_02545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N91_02550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N91_02565	COG0668	transmembrane transport
E4N91_02580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N91_02585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N91_02585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N91_02590	COG1329	Transcriptional regulator
E4N91_02595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N91_02605	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N91_02610	COG3956	TIGRFAM MazG family protein
E4N91_02635	COG0577	efflux transmembrane transporter activity
E4N91_02635	COG1136	(ABC) transporter
E4N91_02640	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N91_02660	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N91_02670	COG0101	tRNA pseudouridine synthase activity
E4N91_02685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N91_02695	COG1132	(ABC) transporter
E4N91_02705	COG0826	peptidase U32
E4N91_02710	COG0737	Belongs to the 5'-nucleotidase family
E4N91_02750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N91_02775	COG3142	Participates in the control of copper homeostasis
E4N91_02800	COG4865	methylaspartate mutase activity
E4N91_02815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N91_02820	COG1120	ATPase activity
E4N91_02840	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N91_02850	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N91_02870	COG0442	prolyl-tRNA aminoacylation
E4N91_02885	COG1879	ABC-type sugar transport system periplasmic component
E4N91_02890	COG1129	ABC transporter
E4N91_02895	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N91_02910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N91_02930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N91_02950	COG2056	Na+-H+ antiporter family
E4N91_02955	COG1757	Na H antiporter
E4N91_02965	COG0626	cystathionine gamma-synthase activity
E4N91_02970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N91_02975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N91_02975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N91_02975	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N91_02975	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N91_02985	COG0564	pseudouridine synthase activity
E4N91_02990	COG0156	8-amino-7-oxononanoate synthase activity
E4N91_03000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N91_03010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N91_03010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N91_03015	COG0739	heme binding
E4N91_03025	COG1475	DNA binding
E4N91_03030	COG1022	Amp-dependent synthetase and ligase
E4N91_03055	COG0671	phosphoesterase, PA-phosphatase related
E4N91_03060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N91_03080	COG1028	Short-chain dehydrogenase reductase Sdr
E4N91_03135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N91_03145	COG2738	Putative neutral zinc metallopeptidase
E4N91_03150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4N91_03150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4N91_03155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N91_03165	COG1129	ABC transporter
E4N91_03180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N91_03185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N91_03195	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N91_03200	COG1671	Belongs to the UPF0178 family
E4N91_03210	COG0741	lytic transglycosylase activity
E4N91_03210	COG1388	LysM domain
E4N91_03235	COG3681	Belongs to the UPF0597 family
E4N91_03240	COG4953	penicillin-binding protein 1C
E4N91_03245	COG1770	oligopeptidase
E4N91_03275	COG1122	ATPase activity
E4N91_03320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N91_03365	COG1131	(ABC) transporter
E4N91_03385	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N91_03390	COG0513	Belongs to the DEAD box helicase family
E4N91_03400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N91_03415	COG3876	Protein conserved in bacteria
E4N91_03420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N91_03445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N91_03450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N91_03455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N91_03460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N91_03465	COG0484	heat shock protein binding
E4N91_03470	COG0528	UMP kinase activity
E4N91_03475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N91_03490	COG0539	negative regulation of cytoplasmic translation
E4N91_03495	COG2204	response regulator
E4N91_03500	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N91_03515	COG5001	Diguanylate cyclase
E4N91_03520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N91_03545	COG0251	oxidation-reduction process
E4N91_03555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N91_03560	COG1722	exodeoxyribonuclease VII activity
E4N91_03570	COG1918	ferrous iron import across plasma membrane
E4N91_03575	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4N91_03575	COG1918	ferrous iron import across plasma membrane
E4N91_03620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N91_03640	COG4166	transmembrane transport
E4N91_03655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N91_03670	COG0552	protein localization to endoplasmic reticulum
E4N91_03680	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N91_03685	COG1136	(ABC) transporter
E4N91_03695	COG3880	PFAM UvrB UvrC protein
E4N91_03700	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N91_03710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N91_03715	COG0438	transferase activity, transferring glycosyl groups
E4N91_03725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N91_03735	COG0084	hydrolase, TatD family'
E4N91_03740	COG2885	chlorophyll binding
E4N91_03830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N91_03840	COG1132	(ABC) transporter
E4N91_03840	COG2375	cellular response to nickel ion
E4N91_03850	COG1309	transcriptional regulator
E4N91_03870	COG1164	Oligoendopeptidase f
E4N91_03880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N91_03885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N91_03900	COG0606	chelatase, subunit chli
E4N91_03910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4N91_03910	COG2885	chlorophyll binding
E4N91_03920	COG1199	ATP-dependent helicase activity
E4N91_03930	COG0823	Involved in the tonB-independent uptake of proteins
E4N91_03945	COG4254	PFAM FecR protein
E4N91_03995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N91_04000	COG1286	toxin biosynthetic process
E4N91_04010	COG3852	Histidine kinase
E4N91_04015	COG2204	response regulator
E4N91_04020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N91_04035	COG0475	glutathione-regulated potassium exporter activity
E4N91_04040	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N91_04095	COG1234	tRNA 3'-trailer cleavage
E4N91_04100	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N91_04105	COG3845	ABC transporter
E4N91_04110	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N91_04145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N91_04200	COG0295	cytidine deaminase activity
E4N91_04235	COG1047	Peptidyl-prolyl cis-trans
E4N91_04260	COG0731	radical SAM domain protein
E4N91_04270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N91_04275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N91_04280	COG1979	alcohol dehydrogenase
E4N91_04285	COG2255	four-way junction helicase activity
E4N91_04295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N91_04300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N91_04305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N91_04315	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N91_04330	COG1725	Transcriptional regulator
E4N91_04335	COG0653	protein targeting
E4N91_04340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N91_04345	COG0138	bifunctional purine biosynthesis protein purh
E4N91_04350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N91_04355	COG2878	Part of a membrane complex involved in electron transport
E4N91_04360	COG0481	GTPase activity
E4N91_04370	COG1114	Component of the transport system for branched-chain amino acids
E4N91_04385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N91_04400	COG2723	6-phospho-beta-galactosidase activity
E4N91_04415	COG0488	(ABC) transporter
E4N91_04425	COG0793	Belongs to the peptidase S41A family
E4N91_04465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N91_04470	COG0632	four-way junction helicase activity
E4N91_04525	COG1136	(ABC) transporter
E4N91_04530	COG0577	efflux transmembrane transporter activity
E4N91_04530	COG1136	(ABC) transporter
E4N91_04770	COG1418	mRNA catabolic process
E4N91_04795	COG2033	superoxide reductase activity
E4N91_04800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N91_04805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N91_04815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N91_04820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N91_04840	COG2059	Chromate
E4N91_04875	COG0739	heme binding
E4N91_04885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N91_04895	COG0708	Exodeoxyribonuclease III
E4N91_04900	COG0024	Methionine aminopeptidase
E4N91_04915	COG3250	beta-galactosidase activity
E4N91_04930	COG1233	COG1233 Phytoene dehydrogenase and related
E4N91_04935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4N91_04935	COG1017	nitric oxide dioxygenase activity
E4N91_04955	COG0617	tRNA 3'-terminal CCA addition
E4N91_04975	COG0519	Catalyzes the synthesis of GMP from XMP
E4N91_04990	COG0126	phosphoglycerate kinase activity
E4N91_04995	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N91_05015	COG0268	Binds directly to 16S ribosomal RNA
E4N91_05020	COG0776	regulation of translation
E4N91_05025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N91_05035	COG1546	Belongs to the CinA family
E4N91_05035	COG1058	Belongs to the CinA family
E4N91_05080	COG0588	phosphoglycerate mutase activity
E4N91_05110	COG1131	(ABC) transporter
E4N91_05120	COG0457	Tetratricopeptide repeat
E4N91_05125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N91_05130	COG3706	GGDEF domain
E4N91_05130	COG2203	Gaf domain
E4N91_05130	COG4251	negative regulation of phosphorylation
E4N91_05130	COG5001	Diguanylate cyclase
E4N91_05135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N91_05140	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N91_05145	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N91_05150	COG1394	ATPase activity, coupled to movement of substances
E4N91_05155	COG1269	ATP hydrolysis coupled proton transport
E4N91_05165	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N91_05170	COG0629	single-stranded DNA binding
E4N91_05175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N91_05180	COG0359	binds to the 23S rRNA
E4N91_05190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N91_05195	COG0740	serine-type endopeptidase activity
E4N91_05200	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N91_05220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N91_05230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N91_05250	COG0305	Participates in initiation and elongation during chromosome replication
E4N91_05265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N91_05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N91_05275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N91_05295	COG1132	(ABC) transporter
E4N91_05300	COG1132	(ABC) transporter
E4N91_05305	COG1268	BioY protein
E4N91_05310	COG1122	ATPase activity
E4N91_05335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N91_05350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N91_05355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N91_05365	COG0237	dephospho-CoA kinase activity
E4N91_05370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N91_05370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N91_05370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N91_05390	COG3052	prosthetic group binding
E4N91_05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N91_05420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N91_05425	COG0509	glycine decarboxylation via glycine cleavage system
E4N91_05430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N91_05435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N91_05455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N91_05475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N91_05505	COG1061	Type III restriction enzyme res subunit
E4N91_05535	COG1129	ABC transporter
E4N91_05540	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N91_05545	COG0493	'glutamate synthase
E4N91_05545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N91_05555	COG0488	(ABC) transporter
E4N91_05560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N91_05570	COG0835	chemotaxis
E4N91_05585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N91_05605	COG0297	glycogen (starch) synthase activity
E4N91_05610	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N91_05615	COG2982	Protein involved in outer membrane biogenesis
E4N91_05640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N91_05645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4N91_05785	COG0095	Lipoate-protein ligase
E4N91_05795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N91_05800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N91_05805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N91_05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N91_05840	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N91_05860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N91_05865	COG0142	geranyltranstransferase activity
E4N91_05875	COG1692	metallophosphoesterase
E4N91_05895	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N91_05925	COG1136	(ABC) transporter
E4N91_05930	COG0577	efflux transmembrane transporter activity
E4N91_05945	COG3470	protein probably involved in high-affinity Fe2 transport
E4N91_05950	COG0672	)-iron permease
E4N91_05955	COG1136	(ABC) transporter
E4N91_05965	COG1760	l-serine dehydratase
E4N91_05970	COG1760	l-serine dehydratase
E4N91_05980	COG0254	rRNA binding
E4N91_05985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N91_06000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N91_06000	COG0574	Belongs to the PEP-utilizing enzyme family
E4N91_06010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N91_06015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N91_06025	COG1196	nuclear chromosome segregation
E4N91_06035	COG2201	protein-glutamate methylesterase activity
E4N91_06045	COG0835	chemotaxis
E4N91_06065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N91_06070	COG0217	transcriptional regulatory protein
E4N91_06120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N91_06125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N91_06135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N91_06135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N91_06150	COG0802	atpase or kinase
E4N91_06160	COG3437	response regulator, receiver
E4N91_06160	COG2770	Histidine kinase
E4N91_06165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N91_06175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N91_06185	COG0009	L-threonylcarbamoyladenylate synthase
E4N91_06220	COG1136	(ABC) transporter
E4N91_06230	COG0745	RESPONSE REGULATOR receiver
E4N91_06230	COG2205	protein histidine kinase activity
E4N91_06230	COG3292	Two component regulator propeller
E4N91_06235	COG0745	RESPONSE REGULATOR receiver
E4N91_06250	COG2190	(PTS) system
E4N91_06250	COG2211	Major facilitator Superfamily
E4N91_06265	COG1193	negative regulation of DNA recombination
E4N91_06270	COG1162	GTPase activity
E4N91_06280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N91_06295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N91_06305	COG0124	histidyl-tRNA synthetase
E4N91_06320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N91_06325	COG0438	transferase activity, transferring glycosyl groups
E4N91_06335	COG0706	membrane insertase activity
E4N91_06340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4N91_06345	COG1216	Glycosyl transferase, family 2
E4N91_06345	COG1442	glycosyl transferase family 8
E4N91_06355	COG0438	transferase activity, transferring glycosyl groups
E4N91_06360	COG0463	Glycosyl transferase, family 2
E4N91_06365	COG0463	Glycosyl transferase, family 2
E4N91_06365	COG1216	Glycosyl transferase, family 2
E4N91_06370	COG1442	glycosyl transferase family 8
E4N91_06370	COG1216	Glycosyl transferase, family 2
E4N91_06385	COG1216	Glycosyl transferase, family 2
E4N91_06400	COG1086	Polysaccharide biosynthesis protein
E4N91_06430	COG0028	Belongs to the TPP enzyme family
E4N91_06430	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N91_06440	COG0475	glutathione-regulated potassium exporter activity
E4N91_06465	COG1078	dGTPase activity
E4N91_06475	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N91_06485	COG0488	(ABC) transporter
E4N91_06495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N91_06495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N91_06500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N91_06540	COG4658	electron transport chain
E4N91_06545	COG4656	Part of a membrane complex involved in electron transport
E4N91_06560	COG0564	pseudouridine synthase activity
E4N91_06570	COG2217	Heavy metal translocating P-type atpase
E4N91_06575	COG0640	Transcriptional regulator
E4N91_06580	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N91_06610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N91_06625	COG0557	exoribonuclease II activity
E4N91_06630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N91_06630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N91_06635	COG0556	nucleotide-excision repair
E4N91_06645	COG0346	lactoylglutathione lyase activity
E4N91_06650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N91_06660	COG0525	valine-tRNA ligase activity
E4N91_06675	COG2252	PERMEase
E4N91_06710	COG0772	Belongs to the SEDS family
E4N91_06715	COG0768	penicillin binding
E4N91_06730	COG1077	Cell shape determining protein MreB Mrl
E4N91_06750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N91_06755	COG0358	DNA primase activity
E4N91_06770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N91_06775	COG0457	Tetratricopeptide repeat
E4N91_06780	COG0037	tRNA processing
E4N91_06785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N91_06795	COG2088	sporulation resulting in formation of a cellular spore
E4N91_06800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N91_06825	COG0330	HflC and HflK could
E4N91_06830	COG0330	HflC and HflK could
E4N91_06840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N91_06875	COG1739	Uncharacterized protein family UPF0029
E4N91_06900	COG2604	Protein of unknown function DUF115
E4N91_06905	COG0768	penicillin binding
E4N91_06915	COG0433	COG0433 Predicted ATPase
E4N91_06920	COG4988	ABC transporter
E4N91_06930	COG0312	modulator of DNA gyrase
E4N91_06935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N91_06965	COG0497	DNA recombination
E4N91_06985	COG0791	NLP P60 protein
E4N91_06985	COG1388	LysM domain
E4N91_06995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N91_07000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N91_07005	COG0312	modulator of DNA gyrase
E4N91_07010	COG0312	modulator of DNA gyrase
E4N91_07030	COG0535	radical SAM domain protein
E4N91_07070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N91_07075	COG0840	transmembrane signaling receptor activity
E4N91_07115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N91_07120	COG4475	Protein of unknown function (DUF436)
E4N91_07130	COG0601	transmembrane transport
E4N91_07135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_07145	COG0444	Belongs to the ABC transporter superfamily
E4N91_07150	COG4608	Belongs to the ABC transporter superfamily
E4N91_07185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N91_07190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N91_07195	COG3118	belongs to the thioredoxin family
E4N91_07205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N91_07210	COG4750	Nucleotidyl transferase
E4N91_07215	COG1115	amino acid carrier protein
E4N91_07240	COG1193	negative regulation of DNA recombination
E4N91_07290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N91_07295	COG1480	7TM receptor with intracellular HD hydrolase
E4N91_07300	COG1702	phosphate starvation-inducible protein PhoH
E4N91_07315	COG0149	triose-phosphate isomerase activity
E4N91_07340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N91_07355	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N91_07360	COG1121	(ABC) transporter
E4N91_07365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N91_07370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N91_07395	COG1157	protein secretion by the type III secretion system
E4N91_07400	COG1317	bacterial-type flagellum organization
E4N91_07410	COG1766	The M ring may be actively involved in energy transduction
E4N91_07415	COG1677	Flagellar hook-basal body complex protein FliE
E4N91_07430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N91_07435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N91_07440	COG4974	Belongs to the 'phage' integrase family
E4N91_07445	COG0551	DNA topoisomerase type I activity
E4N91_07445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N91_07450	COG0758	DNA mediated transformation
E4N91_07460	COG4974	Belongs to the 'phage' integrase family
E4N91_07465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N91_07480	COG0772	Belongs to the SEDS family
E4N91_07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N91_07495	COG0275	rRNA processing
E4N91_07500	COG2001	Belongs to the MraZ family
E4N91_07505	COG1505	serine-type exopeptidase activity
E4N91_07545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N91_07555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4N91_07585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N91_07590	COG1120	ATPase activity
E4N91_07600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N91_07605	COG0459	protein refolding
E4N91_07620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N91_07625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N91_07665	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N91_07685	COG3033	Beta-eliminating lyase
E4N91_07710	COG0563	adenylate kinase activity
E4N91_07730	COG0779	Required for maturation of 30S ribosomal subunits
E4N91_07740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N91_07745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N91_07750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N91_07790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N91_07795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N91_07805	COG3330	Domain of unknown function (DUF4912)
E4N91_07820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N91_07830	COG3706	GGDEF domain
E4N91_07835	COG1102	Psort location Cytoplasmic, score
E4N91_07840	COG1561	YicC-like family, N-terminal region
E4N91_07855	COG0564	pseudouridine synthase activity
E4N91_07870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N91_07875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N91_07880	COG0426	domain, Protein
E4N91_07880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N91_07890	COG4608	Belongs to the ABC transporter superfamily
E4N91_07895	COG0444	Belongs to the ABC transporter superfamily
E4N91_07900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_07920	COG0601	transmembrane transport
E4N91_07925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_07930	COG0444	Belongs to the ABC transporter superfamily
E4N91_07935	COG4608	Belongs to the ABC transporter superfamily
E4N91_07955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N91_07955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N91_07975	COG0534	Mate efflux family protein
E4N91_07980	COG0840	transmembrane signaling receptor activity
E4N91_08005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N91_08010	COG0049	tRNA binding
E4N91_08015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N91_08040	COG0756	dUTP diphosphatase activity
E4N91_08045	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N91_08050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N91_08055	COG0196	riboflavin kinase activity
E4N91_08065	COG0598	Magnesium transport protein CorA
E4N91_08070	COG0617	tRNA 3'-terminal CCA addition
E4N91_08080	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N91_08085	COG0571	ribonuclease III activity
E4N91_08090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N91_08095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N91_08105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N91_08125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N91_08125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N91_08140	COG1067	ATP-dependent peptidase activity
E4N91_08150	COG2703	oxygen carrier activity
E4N91_08155	COG2183	response to ionizing radiation
E4N91_08165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N91_08170	COG0840	transmembrane signaling receptor activity
E4N91_08175	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N91_08185	COG4786	Flagellar basal body rod
E4N91_08205	COG2084	Dehydrogenase
E4N91_08210	COG2116	formate transmembrane transporter activity
E4N91_08215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4N91_08235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N91_08245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N91_08260	COG4166	transmembrane transport
E4N91_08265	COG4166	transmembrane transport
E4N91_08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_08275	COG4174	ABC transporter (Permease)
E4N91_08280	COG0747	negative chemotaxis
E4N91_08285	COG4608	Belongs to the ABC transporter superfamily
E4N91_08290	COG0444	Belongs to the ABC transporter superfamily
E4N91_08300	COG4239	(ABC) transporter, permease
E4N91_08305	COG4174	ABC transporter (Permease)
E4N91_08320	COG0017	Asparaginyl-tRNA synthetase
E4N91_08325	COG1686	Belongs to the peptidase S11 family
E4N91_08350	COG2003	Belongs to the UPF0758 family
E4N91_08355	COG1040	competence protein
E4N91_08360	COG0018	arginyl-trna synthetase
E4N91_08375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N91_08390	COG1692	metallophosphoesterase
E4N91_08400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N91_08410	COG0484	heat shock protein binding
E4N91_08415	COG2089	acid synthase
E4N91_08420	COG5341	Protein conserved in bacteria
E4N91_08425	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N91_08430	COG0584	glycerophosphoryl diester phosphodiesterase
E4N91_08435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N91_08440	COG1704	LemA family
E4N91_08445	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N91_08450	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N91_08455	COG3845	ABC transporter
E4N91_08460	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N91_08475	COG0148	phosphopyruvate hydratase activity
E4N91_08480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N91_08495	COG0318	PFAM AMP-dependent synthetase and ligase
E4N91_08500	COG0791	NLP P60 protein
E4N91_08510	COG3735	TraB family
E4N91_08515	COG0116	Belongs to the methyltransferase superfamily
E4N91_08520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N91_08525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N91_08530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N91_08535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N91_08545	COG0534	Mate efflux family protein
E4N91_08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N91_08560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N91_08565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N91_08580	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N91_08585	COG1132	(ABC) transporter
E4N91_08585	COG2375	cellular response to nickel ion
E4N91_08590	COG1132	(ABC) transporter
E4N91_08595	COG1132	(ABC) transporter
E4N91_08600	COG1132	(ABC) transporter
E4N91_08610	COG0433	COG0433 Predicted ATPase
E4N91_08635	COG1132	(ABC) transporter
E4N91_08650	COG1129	ABC transporter
E4N91_08660	COG0210	DNA helicase
E4N91_08675	COG1129	ABC transporter
E4N91_08690	COG1132	(ABC) transporter
E4N91_08695	COG2375	cellular response to nickel ion
E4N91_08695	COG1132	(ABC) transporter
E4N91_08700	COG2207	Transcriptional regulator
E4N91_08710	COG4555	ABC transporter
E4N91_08725	COG2378	regulation of single-species biofilm formation
E4N91_08755	COG0335	large ribosomal subunit rRNA binding
E4N91_08760	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N91_08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N91_08770	COG1837	Belongs to the UPF0109 family
E4N91_08775	COG0228	four-way junction DNA binding
E4N91_08790	COG1136	(ABC) transporter
E4N91_08790	COG0577	efflux transmembrane transporter activity
E4N91_08805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N91_08810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N91_08815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N91_08820	COG0737	Belongs to the 5'-nucleotidase family
E4N91_08855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N91_08860	COG1285	pathogenesis
E4N91_08880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N91_08885	COG1187	pseudouridine synthase activity
E4N91_08910	COG2197	response regulator
E4N91_08915	COG2137	regulation of response to DNA damage stimulus
E4N91_08925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N91_08950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N91_08960	COG0574	Belongs to the PEP-utilizing enzyme family
E4N91_08960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N91_08975	COG2304	oxidoreductase activity
E4N91_08985	COG1054	Belongs to the UPF0176 family
E4N91_08990	COG4656	Part of a membrane complex involved in electron transport
E4N91_08995	COG4658	electron transport chain
E4N91_09000	COG4659	FMN binding
E4N91_09005	COG4660	Part of a membrane complex involved in electron transport
E4N91_09010	COG4657	Part of a membrane complex involved in electron transport
E4N91_09030	COG1362	aminopeptidase activity
E4N91_09035	COG0445	tRNA wobble uridine modification
E4N91_09040	COG3422	double-strand break repair
E4N91_09045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N91_09050	COG2340	Cysteine-rich secretory protein family
E4N91_09055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N91_09070	COG1132	(ABC) transporter
E4N91_09075	COG1132	(ABC) transporter
E4N91_09080	COG1132	(ABC) transporter
E4N91_09115	COG3339	Conserved Protein
E4N91_09140	COG1690	Belongs to the RtcB family
E4N91_09150	COG2910	NAD(P)H-binding
E4N91_09155	COG1959	2 iron, 2 sulfur cluster binding
E4N91_09175	COG1254	Belongs to the acylphosphatase family
E4N91_09200	COG0203	ribosomal protein L17
E4N91_09205	COG0202	RNA polymerase activity
E4N91_09210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N91_09215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N91_09220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N91_09230	COG0200	Binds to the 23S rRNA
E4N91_09235	COG1841	ribosomal large subunit assembly
E4N91_09240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N91_09245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N91_09250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N91_09255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N91_09260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N91_09265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N91_09270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N91_09275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N91_09280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N91_09285	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N91_09290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N91_09295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N91_09300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N91_09305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N91_09310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N91_09315	COG0089	rRNA binding
E4N91_09320	COG0088	Forms part of the polypeptide exit tunnel
E4N91_09325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N91_09330	COG0051	transcription antitermination factor activity, RNA binding
E4N91_09335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N91_09365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N91_09370	COG1120	ATPase activity
E4N91_09375	COG1757	Na H antiporter
E4N91_09385	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N91_09430	COG0732	type I restriction modification DNA specificity domain
E4N91_09435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N91_09440	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N91_09445	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N91_09445	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N91_09460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N91_09465	COG1120	ATPase activity
E4N91_09475	COG3118	belongs to the thioredoxin family
E4N91_09525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N91_09545	COG1086	Polysaccharide biosynthesis protein
E4N91_09590	COG0330	HflC and HflK could
E4N91_09605	COG1131	(ABC) transporter
E4N91_09645	COG1131	(ABC) transporter
E4N91_09650	COG0351	phosphomethylpyrimidine kinase
E4N91_09660	COG0482	sulfurtransferase activity
E4N91_09675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N91_09680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N91_09685	COG1028	Short-chain dehydrogenase reductase Sdr
E4N91_09690	COG0629	single-stranded DNA binding
E4N91_09695	COG1862	Preprotein translocase
E4N91_09700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N91_09705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N91_09720	COG0425	Belongs to the sulfur carrier protein TusA family
E4N91_09745	COG2910	NAD(P)H-binding
E4N91_09770	COG0484	heat shock protein binding
E4N91_09785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N91_09800	COG0719	Fe-S assembly protein
E4N91_09805	COG0396	ATPase activity
E4N91_09810	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N91_09810	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N91_09810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N91_09810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N91_09815	COG2885	chlorophyll binding
E4N91_09825	COG4115	mRNA cleavage
E4N91_09850	COG2378	regulation of single-species biofilm formation
E4N91_09865	COG1136	(ABC) transporter
E4N91_09870	COG5002	protein histidine kinase activity
E4N91_09880	COG1473	amidohydrolase
E4N91_09895	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N91_09915	COG2201	protein-glutamate methylesterase activity
E4N91_09935	COG1137	ATPase activity
E4N91_09940	COG0193	aminoacyl-tRNA hydrolase activity
E4N91_09950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N91_09960	COG0601	transmembrane transport
E4N91_09965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_09970	COG0444	Belongs to the ABC transporter superfamily
E4N91_09975	COG4608	Belongs to the ABC transporter superfamily
E4N91_09985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N91_10010	COG0484	heat shock protein binding
E4N91_10015	COG0443	Heat shock 70 kDa protein
E4N91_10020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N91_10030	COG1120	ATPase activity
E4N91_10055	COG0534	Mate efflux family protein
E4N91_10085	COG1192	Involved in chromosome partitioning
E4N91_10090	COG1475	DNA binding
E4N91_10110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N91_10115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N91_10120	COG1028	Short-chain dehydrogenase reductase Sdr
E4N91_10135	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N91_10160	COG0439	Biotin carboxylase
E4N91_10165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N91_10170	COG0825	malonyl-CoA metabolic process
E4N91_10175	COG2986	histidine ammonia-lyase
E4N91_10190	COG0701	Predicted permease
E4N91_10195	COG3689	TIGRFAM TIGR03943 family protein
E4N91_10200	COG0714	Associated with various cellular activities
E4N91_10235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N91_10240	COG0154	amidase activity
E4N91_10245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N91_10320	COG4104	PAAR repeat-containing protein
E4N91_10320	COG3209	COG3209 Rhs family protein
E4N91_10330	COG3209	COG3209 Rhs family protein
E4N91_10440	COG1136	(ABC) transporter
E4N91_10550	COG0456	acetyltransferase
E4N91_10630	COG3041	Addiction module toxin RelE StbE family
E4N91_10685	COG1396	sequence-specific DNA binding
E4N91_10700	COG0745	RESPONSE REGULATOR receiver
E4N91_10725	COG4555	ABC transporter
E4N91_10765	COG1151	hydroxylamine reductase activity
E4N91_10780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N91_10785	COG0577	efflux transmembrane transporter activity
E4N91_10785	COG1136	(ABC) transporter
E4N91_10810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N91_10840	COG0813	purine-nucleoside phosphorylase activity
E4N91_10845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N91_10865	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N91_10870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N91_10885	COG2235	arginine
E4N91_10890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N91_10900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N91_10920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N91_10950	COG0343	queuine tRNA-ribosyltransferase activity
E4N91_10960	COG1381	Involved in DNA repair and RecF pathway recombination
E4N91_10965	COG0514	ATP-dependent DNA helicase (RecQ)
E4N91_10970	COG1592	Rubrerythrin
E4N91_11010	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N91_11015	COG0501	Belongs to the peptidase M48B family
E4N91_11025	COG0543	2 iron, 2 sulfur cluster binding
E4N91_11055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N91_11070	COG0747	negative chemotaxis
E4N91_11075	COG4608	Belongs to the ABC transporter superfamily
E4N91_11080	COG0444	Belongs to the ABC transporter superfamily
E4N91_11085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_11100	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N91_11115	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N91_11135	COG1653	transport
E4N91_11140	COG0395	ABC-type sugar transport system, permease component
E4N91_11150	COG3842	ATPase activity
E4N91_11170	COG0601	transmembrane transport
E4N91_11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_11185	COG4608	Belongs to the ABC transporter superfamily
E4N91_11190	COG4166	transmembrane transport
E4N91_11195	COG0601	transmembrane transport
E4N91_11200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N91_11205	COG0444	Belongs to the ABC transporter superfamily
E4N91_11210	COG4608	Belongs to the ABC transporter superfamily
E4N91_11215	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N91_11220	COG4133	protoheme IX ABC transporter activity
E4N91_11270	COG3842	ATPase activity
E4N91_11290	COG3271	cysteine-type peptidase activity
E4N91_11290	COG2274	protein secretion by the type I secretion system
E4N91_11300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N91_11305	COG1132	(ABC) transporter
E4N91_11320	COG0786	glutamate:sodium symporter activity
E4N91_11325	COG1132	(ABC) transporter
E4N91_11330	COG1132	(ABC) transporter
E4N91_11355	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N91_11365	COG3340	Belongs to the peptidase S51 family
E4N91_11370	COG0698	ribose 5-phosphate isomerase
E4N91_11375	COG0039	L-malate dehydrogenase activity
E4N91_11380	COG0534	Mate efflux family protein
E4N91_11385	COG0574	Belongs to the PEP-utilizing enzyme family
E4N91_11385	COG3848	Pyruvate phosphate dikinase
E4N91_11390	COG1309	transcriptional regulator
E4N91_11395	COG0840	transmembrane signaling receptor activity
E4N91_11415	COG0728	peptidoglycan biosynthetic process
E4N91_11420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N91_11425	COG3588	fructose-bisphosphate aldolase
E4N91_11430	COG1309	transcriptional regulator
E4N91_11440	COG0363	glucosamine-6-phosphate deaminase activity
E4N91_11445	COG0628	permease
E4N91_11450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N91_11460	COG0534	Mate efflux family protein
E4N91_11465	COG1309	transcriptional regulator
E4N91_11475	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N91_11480	COG1518	maintenance of DNA repeat elements
E4N91_11490	COG0514	ATP-dependent DNA helicase (RecQ)
E4N91_11515	COG4536	flavin adenine dinucleotide binding
E4N91_11520	COG4536	flavin adenine dinucleotide binding
E4N91_11525	COG0714	Associated with various cellular activities
E4N91_11540	COG1132	(ABC) transporter
E4N91_11555	COG0569	domain protein
E4N91_11560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N91_11565	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N91_11585	COG0616	signal peptide processing
E4N91_11590	COG0012	GTP binding
E4N91_11620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N91_11630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N91_11635	COG0569	domain protein
E4N91_11645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N91_11660	COG1132	(ABC) transporter
E4N91_11665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4N91_11670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N91_11685	COG1129	ABC transporter
E4N91_11700	COG0596	Alpha beta hydrolase
E4N91_11730	COG1132	(ABC) transporter
E4N91_11730	COG2375	cellular response to nickel ion
E4N91_11735	COG1132	(ABC) transporter
E4N91_11790	COG1846	Transcriptional regulator
E4N91_11795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N91_11810	COG1129	ABC transporter
E4N91_11835	COG0733	neurotransmitter:sodium symporter activity
E4N91_11845	COG3189	MarR family transcriptional regulator
E4N91_11850	COG1309	transcriptional regulator
E4N91_11855	COG1132	(ABC) transporter
E4N91_11860	COG1132	(ABC) transporter
E4N91_11865	COG1132	(ABC) transporter
E4N91_11870	COG1132	(ABC) transporter
E4N91_11900	COG1131	(ABC) transporter
E4N91_11905	COG1309	transcriptional regulator
E4N91_11930	COG1129	ABC transporter
E4N91_11945	COG1132	(ABC) transporter
E4N91_11950	COG1132	(ABC) transporter
E4N91_11950	COG2375	cellular response to nickel ion
E4N91_11980	COG1418	mRNA catabolic process
E4N91_12000	COG3177	Filamentation induced by cAMP protein fic
E4N91_12005	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N91_12010	COG0592	DNA-directed DNA polymerase activity
E4N91_12015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N91_12030	COG3549	Plasmid maintenance system killer
E4N91_12130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N91_12145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N91_12150	COG1929	Belongs to the glycerate kinase type-1 family
E4N91_12155	COG2610	gluconate transmembrane transporter activity
E4N91_12170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N91_12185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N91_12235	COG0730	response to heat
E4N91_12265	COG4208	sulfate ABC transporter
E4N91_12270	COG3839	Belongs to the ABC transporter superfamily
E4N91_12275	COG0840	transmembrane signaling receptor activity
E4N91_12280	COG0840	transmembrane signaling receptor activity
E4N91_12295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N91_12305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N91_12310	COG1674	ftsk spoiiie
E4N91_12315	COG1968	undecaprenyl-diphosphatase activity
E4N91_12320	COG0419	ATPase involved in DNA repair
E4N91_12325	COG0420	3'-5' exonuclease activity
E4N91_12330	COG3290	protein histidine kinase activity
E4N91_12330	COG0840	transmembrane signaling receptor activity
E4N91_12340	COG1131	(ABC) transporter
E4N91_12360	COG0716	FMN binding
E4N91_12395	COG0800	Aldolase
E4N91_12420	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N91_12445	COG4585	Histidine kinase
E4N91_12450	COG1473	amidohydrolase
E4N91_12485	COG1823	symporter activity
E4N91_12490	COG0540	Belongs to the ATCase OTCase family
E4N91_12490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N91_12495	COG5001	Diguanylate cyclase
E4N91_12495	COG5002	protein histidine kinase activity
E4N91_12555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N91_12570	COG1774	PSP1 C-terminal conserved region
E4N91_12575	COG1728	Protein conserved in bacteria
E4N91_12585	COG0739	heme binding
E4N91_12600	COG0366	Alpha amylase catalytic
E4N91_12610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N91_12615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N91_12620	COG1104	cysteine desulfurase activity
E4N91_12635	COG0823	Involved in the tonB-independent uptake of proteins
E4N91_12635	COG1506	peptidase
E4N91_12635	COG4946	Tricorn protease homolog
E4N91_12665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N91_12670	COG0215	cysteine-tRNA ligase activity
E4N91_12685	COG1305	Transglutaminase-like
E4N91_12690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N91_12695	COG0569	domain protein
E4N91_12700	COG2887	Belongs to the helicase family. UvrD subfamily
E4N91_12705	COG1074	ATP-dependent DNA helicase activity
E4N91_12755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N91_12775	COG1012	belongs to the aldehyde dehydrogenase family
E4N91_12785	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E4N91_12800	COG1830	Aldolase
E4N91_12805	COG1063	alcohol dehydrogenase
E4N91_12810	COG0531	amino acid
E4N91_12815	COG0196	riboflavin kinase activity
E4N91_12820	COG0840	transmembrane signaling receptor activity
E4N91_12825	COG0826	peptidase U32
E4N91_12830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N91_12835	COG1509	lysine 2,3-aminomutase activity
E4N91_12840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N91_12845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N91_12860	COG0205	6-phosphofructokinase activity
E4N91_12895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N91_12905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N91_12910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N91_12915	COG1684	flagellar biosynthetic protein fliR
E4N91_12920	COG1987	bacterial-type flagellum assembly
E4N91_12940	COG1228	amidohydrolase
E4N91_12955	COG0457	Tetratricopeptide repeat
E4N91_12960	COG0280	phosphate acetyltransferase
E4N91_12970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N91_12975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N91_13005	COG3279	Response regulator of the LytR AlgR family
E4N91_13030	COG1132	(ABC) transporter
E4N91_13060	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N91_13080	COG0423	glycine-tRNA ligase activity
E4N91_13085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N91_13095	COG1363	Peptidase, m42
E4N91_13100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N91_13115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N91_13120	COG1966	Carbon starvation protein
E4N91_13125	COG0450	alkyl hydroperoxide reductase
E4N91_13130	COG0494	nUDIX hydrolase
E4N91_13150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N91_13170	COG0187	DNA topoisomerase II activity