locus-tag	class	description
MWR63_00010	COG0592	DNA-directed DNA polymerase activity
MWR63_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MWR63_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MWR63_00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MWR63_00030	COG1609	Transcriptional regulator
MWR63_00055	COG1609	Transcriptional regulator
MWR63_00065	COG1067	ATP-dependent peptidase activity
MWR63_00075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MWR63_00075	COG1747	RNA polymerase binding
MWR63_00125	COG0733	neurotransmitter:sodium symporter activity
MWR63_00140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MWR63_00150	COG1253	flavin adenine dinucleotide binding
MWR63_00155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MWR63_00170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MWR63_00180	COG0803	Belongs to the bacterial solute-binding protein 9 family
MWR63_00185	COG1121	(ABC) transporter
MWR63_00190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MWR63_00195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MWR63_00210	COG1652	LysM domain
MWR63_00230	COG1774	PSP1 C-terminal conserved region
MWR63_00245	COG0739	heme binding
MWR63_00255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MWR63_00260	COG2890	protein-(glutamine-N5) methyltransferase activity
MWR63_00265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MWR63_00275	COG3630	sodium ion export across plasma membrane
MWR63_00285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MWR63_00290	COG0305	Participates in initiation and elongation during chromosome replication
MWR63_00310	COG0629	single-stranded DNA binding
MWR63_00355	COG0542	response to heat
MWR63_00365	COG1639	'signal transduction protein
MWR63_00375	COG1175	transmembrane transport
MWR63_00380	COG0395	ABC-type sugar transport system, permease component
MWR63_00390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MWR63_00405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MWR63_00410	COG3604	Transcriptional regulator
MWR63_00425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MWR63_00425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MWR63_00425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MWR63_00445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWR63_00450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MWR63_00470	COG0280	phosphate acetyltransferase
MWR63_00475	COG0457	Tetratricopeptide repeat
MWR63_00485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MWR63_00490	COG0484	heat shock protein binding
MWR63_00500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MWR63_00505	COG0785	Cytochrome C biogenesis protein
MWR63_00520	COG0737	Belongs to the 5'-nucleotidase family
MWR63_00525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MWR63_00525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MWR63_00525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MWR63_00535	COG4750	Nucleotidyl transferase
MWR63_00540	COG0205	6-phosphofructokinase activity
MWR63_00570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MWR63_00575	COG3579	cysteine-type endopeptidase activity
MWR63_00580	COG0330	HflC and HflK could
MWR63_00585	COG0330	HflC and HflK could
MWR63_00590	COG0351	phosphomethylpyrimidine kinase
MWR63_00610	COG2011	ABC-type metal ion transport system permease component
MWR63_00615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MWR63_00620	COG1509	lysine 2,3-aminomutase activity
MWR63_00630	COG0457	Tetratricopeptide repeat
MWR63_00635	COG0012	GTP binding
MWR63_00640	COG0708	Exodeoxyribonuclease III
MWR63_00710	COG0569	domain protein
MWR63_00715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MWR63_00720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MWR63_00740	COG1022	Amp-dependent synthetase and ligase
MWR63_00760	COG1449	Belongs to the glycosyl hydrolase 57 family
MWR63_00790	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MWR63_00830	COG2255	four-way junction helicase activity
MWR63_00835	COG0803	Belongs to the bacterial solute-binding protein 9 family
MWR63_00840	COG1121	(ABC) transporter
MWR63_00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MWR63_00850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MWR63_00870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MWR63_00875	COG4939	FMN-binding domain protein
MWR63_00880	COG2199	diguanylate cyclase activity
MWR63_00905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MWR63_00930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MWR63_00935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MWR63_01065	COG0202	RNA polymerase activity
MWR63_01080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MWR63_01090	COG0484	heat shock protein binding
MWR63_01105	COG1366	Belongs to the anti-sigma-factor antagonist family
MWR63_01155	COG1122	ATPase activity
MWR63_01160	COG1268	BioY protein
MWR63_01165	COG1573	uracil-dna glycosylase
MWR63_01170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MWR63_01175	COG0564	pseudouridine synthase activity
MWR63_01200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MWR63_01205	COG0250	Participates in transcription elongation, termination and antitermination
MWR63_01230	COG0085	RNA polymerase activity
MWR63_01250	COG0714	Associated with various cellular activities
MWR63_01255	COG2304	oxidoreductase activity
MWR63_01260	COG0860	N-Acetylmuramoyl-L-alanine amidase
MWR63_01285	COG0776	regulation of translation
MWR63_01290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MWR63_01300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MWR63_01310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MWR63_01315	COG0584	glycerophosphoryl diester phosphodiesterase
MWR63_01340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MWR63_01360	COG1114	Component of the transport system for branched-chain amino acids
MWR63_01395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MWR63_01400	COG0617	tRNA 3'-terminal CCA addition
MWR63_01405	COG1475	DNA binding
MWR63_01410	COG1192	Involved in chromosome partitioning
MWR63_01435	COG0793	Belongs to the peptidase S41A family
MWR63_01445	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MWR63_01455	COG0731	radical SAM domain protein
MWR63_01465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MWR63_01470	COG0561	phosphatase activity
MWR63_01480	COG2885	chlorophyll binding
MWR63_01485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MWR63_01495	COG0237	dephospho-CoA kinase activity
MWR63_01505	COG1744	ABC transporter substrate-binding protein PnrA-like
MWR63_01510	COG3845	ABC transporter
MWR63_01515	COG4603	Belongs to the binding-protein-dependent transport system permease family
MWR63_01520	COG1079	Belongs to the binding-protein-dependent transport system permease family
MWR63_01525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MWR63_01530	COG0823	Involved in the tonB-independent uptake of proteins
MWR63_01600	COG1744	ABC transporter substrate-binding protein PnrA-like
MWR63_01610	COG3845	ABC transporter
MWR63_01615	COG4603	Belongs to the binding-protein-dependent transport system permease family
MWR63_01620	COG1079	Belongs to the binding-protein-dependent transport system permease family
MWR63_01625	COG2911	Protein conserved in bacteria
MWR63_01630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MWR63_01645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MWR63_01665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MWR63_01705	COG0285	dihydrofolate synthase activity
MWR63_01715	COG1102	Psort location Cytoplasmic, score
MWR63_01750	COG1047	Peptidyl-prolyl cis-trans
MWR63_01765	COG4443	Transcriptional Coactivator p15 (PC4)
MWR63_01775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MWR63_01795	COG1543	Belongs to the glycosyl hydrolase 57 family
MWR63_01800	COG3330	Domain of unknown function (DUF4912)
MWR63_01820	COG0643	Histidine kinase
MWR63_01820	COG2198	Histidine kinase
MWR63_01825	COG0835	chemotaxis
MWR63_01835	COG2201	protein-glutamate methylesterase activity
MWR63_01840	COG1196	nuclear chromosome segregation
MWR63_01850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MWR63_01880	COG0457	Tetratricopeptide repeat
MWR63_01905	COG0653	protein targeting
MWR63_01915	COG5522	Integral membrane protein (intg_mem_TP0381)
MWR63_01935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MWR63_01945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MWR63_01955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MWR63_01960	COG4974	Belongs to the 'phage' integrase family
MWR63_01970	COG0758	DNA mediated transformation
MWR63_01975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MWR63_01975	COG0551	DNA topoisomerase type I activity
MWR63_01980	COG4974	Belongs to the 'phage' integrase family
MWR63_01985	COG1815	bacterial-type flagellum-dependent cell motility
MWR63_02000	COG1766	The M ring may be actively involved in energy transduction
MWR63_02010	COG1317	bacterial-type flagellum organization
MWR63_02015	COG1157	protein secretion by the type III secretion system
MWR63_02025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MWR63_02055	COG1862	Preprotein translocase
MWR63_02060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MWR63_02065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MWR63_02080	COG1115	amino acid carrier protein
MWR63_02085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MWR63_02090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MWR63_02095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MWR63_02100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MWR63_02130	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MWR63_02135	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MWR63_02140	COG1394	ATPase activity, coupled to movement of substances
MWR63_02145	COG1269	ATP hydrolysis coupled proton transport
MWR63_02155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MWR63_02170	COG3015	lipoprotein NlpE involved in copper resistance
MWR63_02175	COG1227	inorganic diphosphatase activity
MWR63_02190	COG0835	chemotaxis
MWR63_02205	COG0497	DNA recombination
MWR63_02225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MWR63_02230	COG3118	belongs to the thioredoxin family
MWR63_02235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MWR63_02240	COG0457	Tetratricopeptide repeat
MWR63_02245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MWR63_02270	COG3706	GGDEF domain
MWR63_02290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MWR63_02375	COG0363	glucosamine-6-phosphate deaminase activity
MWR63_02380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MWR63_02390	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
MWR63_02395	COG2982	Protein involved in outer membrane biogenesis
MWR63_02405	COG4254	PFAM FecR protein
MWR63_02420	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MWR63_02425	COG0840	transmembrane signaling receptor activity
MWR63_02450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MWR63_02455	COG0358	DNA primase activity
MWR63_02460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MWR63_02480	COG1077	Cell shape determining protein MreB Mrl
MWR63_02495	COG0768	penicillin binding
MWR63_02500	COG0772	Belongs to the SEDS family
MWR63_02505	COG0666	response to abiotic stimulus
MWR63_02540	COG0740	serine-type endopeptidase activity
MWR63_02550	COG0450	alkyl hydroperoxide reductase
MWR63_02560	COG1329	Transcriptional regulator
MWR63_02565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MWR63_02565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MWR63_02575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MWR63_02585	COG0728	peptidoglycan biosynthetic process
MWR63_02600	COG2204	response regulator
MWR63_02605	COG4191	Histidine kinase
MWR63_02610	COG3852	Histidine kinase
MWR63_02615	COG0470	DNA polymerase III
MWR63_02620	COG1286	toxin biosynthetic process
MWR63_02630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MWR63_02645	COG1394	ATPase activity, coupled to movement of substances
MWR63_02650	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MWR63_02655	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MWR63_02675	COG1269	ATP hydrolysis coupled proton transport
MWR63_02680	COG1527	subunit (C
MWR63_02690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MWR63_02715	COG1366	Belongs to the anti-sigma-factor antagonist family
MWR63_02725	COG0205	6-phosphofructokinase activity
MWR63_02745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWR63_02785	COG0628	permease
MWR63_02790	COG0546	phosphoglycolate phosphatase activity
MWR63_02815	COG0301	tRNA thio-modification
MWR63_02820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MWR63_02825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MWR63_02830	COG2089	acid synthase
MWR63_02860	COG0800	Aldolase
MWR63_02865	COG0006	proline dipeptidase activity
MWR63_02880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MWR63_02880	COG3976	FMN-binding domain protein
MWR63_02890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MWR63_02905	COG0552	protein localization to endoplasmic reticulum
MWR63_02915	COG4591	ABC-type transport system involved in lipoprotein release permease component
MWR63_02920	COG1136	(ABC) transporter
MWR63_02935	COG4166	transmembrane transport
MWR63_02945	COG1466	dna polymerase III delta subunit
MWR63_02950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MWR63_02955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MWR63_02985	COG3064	Membrane
MWR63_03000	COG0617	tRNA 3'-terminal CCA addition
MWR63_03015	COG0750	zinc metalloprotease
MWR63_03020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MWR63_03025	COG0575	Belongs to the CDS family
MWR63_03030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MWR63_03055	COG1413	lyase activity
MWR63_03075	COG0719	Fe-S assembly protein
MWR63_03080	COG0719	Fe-S assembly protein
MWR63_03085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MWR63_03130	COG0741	lytic transglycosylase activity
MWR63_03130	COG1388	LysM domain
MWR63_03145	COG0420	3'-5' exonuclease activity
MWR63_03150	COG0419	ATPase involved in DNA repair
MWR63_03155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MWR63_03170	COG2201	protein-glutamate methylesterase activity
MWR63_03175	COG0180	Tryptophanyl-tRNA synthetase
MWR63_03180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MWR63_03180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MWR63_03220	COG0840	transmembrane signaling receptor activity
MWR63_03220	COG3290	protein histidine kinase activity
MWR63_03225	COG0840	transmembrane signaling receptor activity
MWR63_03235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MWR63_03240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MWR63_03245	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MWR63_03275	COG1480	7TM receptor with intracellular HD hydrolase
MWR63_03280	COG3842	ATPase activity
MWR63_03285	COG1176	ABC-type spermidine putrescine transport system, permease component I
MWR63_03290	COG1177	transmembrane transport
MWR63_03325	COG0191	fructose-bisphosphate aldolase activity
MWR63_03350	COG0572	uridine kinase
MWR63_03365	COG0587	DNA-directed DNA polymerase activity
MWR63_03395	COG2840	Smr protein MutS2
MWR63_03400	COG3735	TraB family
MWR63_03420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MWR63_03445	COG0142	geranyltranstransferase activity
MWR63_03450	COG1879	ABC-type sugar transport system periplasmic component
MWR63_03455	COG1129	ABC transporter
MWR63_03460	COG4211	Belongs to the binding-protein-dependent transport system permease family
MWR63_03465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MWR63_03470	COG1619	proteins homologs of microcin C7 resistance protein MccF
MWR63_03485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MWR63_03510	COG0151	Belongs to the GarS family
MWR63_03545	COG0739	heme binding
MWR63_03550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MWR63_03550	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MWR63_03560	COG0739	heme binding
MWR63_03560	COG0741	lytic transglycosylase activity
MWR63_03560	COG1196	nuclear chromosome segregation
MWR63_03575	COG1191	sigma factor activity
MWR63_03595	COG1419	protein localization to endoplasmic reticulum
MWR63_03600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MWR63_03605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MWR63_03610	COG1684	flagellar biosynthetic protein fliR
MWR63_03615	COG1987	bacterial-type flagellum assembly
MWR63_03620	COG1338	Plays a role in the flagellum-specific transport system
MWR63_03630	COG1776	CheC inhibitor of MCP methylation
MWR63_03630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MWR63_03635	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MWR63_03640	COG1580	Controls the rotational direction of flagella during chemotaxis
MWR63_03645	COG1360	Flagellar Motor Protein
MWR63_03650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MWR63_03660	COG1749	Flagellar hook protein flgE
MWR63_03665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MWR63_03695	COG0813	purine-nucleoside phosphorylase activity
MWR63_03700	COG0493	'glutamate synthase
MWR63_03705	COG0543	2 iron, 2 sulfur cluster binding
MWR63_03715	COG0799	negative regulation of ribosome biogenesis
MWR63_03755	COG0574	Belongs to the PEP-utilizing enzyme family
MWR63_03755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MWR63_03775	COG2304	oxidoreductase activity
MWR63_03820	COG0768	penicillin binding
MWR63_03825	COG2604	Protein of unknown function DUF115
MWR63_03830	COG2604	Protein of unknown function DUF115
MWR63_03845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MWR63_03855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MWR63_03865	COG1652	LysM domain
MWR63_03885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWR63_03900	COG1285	pathogenesis
MWR63_03905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MWR63_03920	COG3956	TIGRFAM MazG family protein
MWR63_03930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MWR63_03930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MWR63_03935	COG0739	heme binding
MWR63_03955	COG1137	ATPase activity
MWR63_03970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MWR63_03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MWR63_04000	COG1477	protein flavinylation
MWR63_04005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MWR63_04010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MWR63_04010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MWR63_04015	COG1686	Belongs to the peptidase S11 family
MWR63_04020	COG0542	response to heat
MWR63_04035	COG3842	ATPase activity
MWR63_04040	COG0557	exoribonuclease II activity
MWR63_04065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MWR63_04080	COG0492	ferredoxin-NADP+ reductase activity
MWR63_04110	COG1464	Belongs to the NlpA lipoprotein family
MWR63_04115	COG0668	transmembrane transport
MWR63_04120	COG2033	superoxide reductase activity
MWR63_04175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MWR63_04195	COG0488	(ABC) transporter
MWR63_04210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MWR63_04215	COG0024	Methionine aminopeptidase
MWR63_04220	COG0484	heat shock protein binding
MWR63_04225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MWR63_04230	COG1671	Belongs to the UPF0178 family
MWR63_04235	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MWR63_04260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MWR63_04265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MWR63_04270	COG0455	bacterial-type flagellum organization
MWR63_04305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MWR63_04310	COG0545	Peptidyl-prolyl cis-trans isomerase
MWR63_04315	COG1104	cysteine desulfurase activity
MWR63_04320	COG1388	LysM domain
MWR63_04320	COG3942	CHAP domain
MWR63_04335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MWR63_04345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MWR63_04350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MWR63_04350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MWR63_04365	COG0802	atpase or kinase
MWR63_04370	COG1214	PFAM Peptidase M22, glycoprotease
MWR63_04375	COG2770	Histidine kinase
MWR63_04375	COG3437	response regulator, receiver
MWR63_04395	COG4555	ABC transporter
MWR63_04445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MWR63_04455	COG0779	Required for maturation of 30S ribosomal subunits
MWR63_04480	COG2887	Belongs to the helicase family. UvrD subfamily
MWR63_04495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MWR63_04510	COG1837	Belongs to the UPF0109 family
MWR63_04515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MWR63_04520	COG0336	Belongs to the RNA methyltransferase TrmD family
MWR63_04535	COG2257	FlhB HrpN YscU SpaS Family
MWR63_04565	COG2239	Acts as a magnesium transporter
MWR63_04575	COG3118	belongs to the thioredoxin family
MWR63_04580	COG0457	Tetratricopeptide repeat
MWR63_04605	COG2183	response to ionizing radiation
MWR63_04615	COG0716	FMN binding
MWR63_04620	COG0681	Belongs to the peptidase S26 family
MWR63_04630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MWR63_04635	COG2604	Protein of unknown function DUF115
MWR63_04645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MWR63_04665	COG1253	flavin adenine dinucleotide binding
MWR63_04680	COG0674	pyruvate-flavodoxin oxidoreductase activity
MWR63_04680	COG1013	pyruvate-flavodoxin oxidoreductase activity
MWR63_04680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MWR63_04680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MWR63_04705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MWR63_04715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MWR63_04720	COG1847	R3H domain protein
MWR63_04725	COG0706	membrane insertase activity
MWR63_04730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MWR63_04735	COG0594	ribonuclease P activity
MWR63_04780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MWR63_04780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MWR63_04785	COG3951	Flagellar rod assembly protein muramidase FlgJ
MWR63_04805	COG0577	efflux transmembrane transporter activity
MWR63_04805	COG1136	(ABC) transporter
MWR63_04810	COG1136	(ABC) transporter
MWR63_04815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MWR63_04840	COG3470	protein probably involved in high-affinity Fe2 transport
MWR63_04845	COG0672	)-iron permease
MWR63_04860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MWR63_04870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MWR63_04875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MWR63_04880	COG0084	hydrolase, TatD family'
MWR63_04885	COG3116	cell division
MWR63_04885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MWR63_04905	COG0326	Molecular chaperone. Has ATPase activity
MWR63_04925	COG2095	MarC family integral membrane protein
MWR63_04940	COG1773	rubredoxin
MWR63_04950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MWR63_04960	COG0084	hydrolase, TatD family'
MWR63_04980	COG0616	signal peptide processing
MWR63_04985	COG1115	amino acid carrier protein
MWR63_04990	COG1674	ftsk spoiiie
MWR63_05015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MWR63_05020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MWR63_05025	COG0187	DNA topoisomerase II activity
MWR63_05030	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MWR63_05035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MWR63_05055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MWR63_05075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MWR63_05080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MWR63_05085	COG1418	mRNA catabolic process
MWR63_05090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MWR63_05105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MWR63_05135	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MWR63_05145	COG0724	RNA recognition motif
MWR63_05155	COG5341	Protein conserved in bacteria
MWR63_05160	COG1752	Esterase of the alpha-beta hydrolase superfamily
MWR63_05165	COG0530	calcium, potassium:sodium antiporter activity
MWR63_05170	COG0525	valine-tRNA ligase activity
MWR63_05180	COG1272	protein, Hemolysin III
MWR63_05185	COG0783	Belongs to the Dps family
MWR63_05195	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MWR63_05200	COG0740	serine-type endopeptidase activity