locus-tag	class	description
TPSea814_000002	COG0592	DNA-directed DNA polymerase activity
TPSea814_000003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPSea814_0000037	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPSea814_000004	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TPSea814_000005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPSea814_000007	COG1609	Transcriptional regulator
TPSea814_000013	COG1609	Transcriptional regulator
TPSea814_000015	COG0072	phenylalanine-tRNA ligase activity
TPSea814_000016	COG1067	ATP-dependent peptidase activity
TPSea814_0000173	COG2199	diguanylate cyclase activity
TPSea814_000018	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPSea814_000018	COG1747	RNA polymerase binding
TPSea814_000023	COG0733	neurotransmitter:sodium symporter activity
TPSea814_000026	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSea814_000028	COG1253	flavin adenine dinucleotide binding
TPSea814_000029	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPSea814_000030	COG0459	protein refolding
TPSea814_000032	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPSea814_000034	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPSea814_000035	COG1121	(ABC) transporter
TPSea814_000036	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSea814_000042	COG1652	LysM domain
TPSea814_000044	COG0445	tRNA wobble uridine modification
TPSea814_000045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TPSea814_000046	COG1774	PSP1 C-terminal conserved region
TPSea814_000049	COG0739	heme binding
TPSea814_000052	COG2890	protein-(glutamine-N5) methyltransferase activity
TPSea814_000053	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPSea814_000055	COG3630	sodium ion export across plasma membrane
TPSea814_000057	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TPSea814_000058	COG0305	Participates in initiation and elongation during chromosome replication
TPSea814_000060	COG0359	binds to the 23S rRNA
TPSea814_000061	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPSea814_000062	COG0629	single-stranded DNA binding
TPSea814_000063	COG0360	Binds together with S18 to 16S ribosomal RNA
TPSea814_000068	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPSea814_000071	COG0542	response to heat
TPSea814_000073	COG1639	'signal transduction protein
TPSea814_000076	COG0395	ABC-type sugar transport system, permease component
TPSea814_000078	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPSea814_000081	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TPSea814_000082	COG3604	Transcriptional regulator
TPSea814_000085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPSea814_000085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSea814_000085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPSea814_000089	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPSea814_000090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPSea814_000091	COG0215	cysteine-tRNA ligase activity
TPSea814_000094	COG0280	phosphate acetyltransferase
TPSea814_000095	COG0457	Tetratricopeptide repeat
TPSea814_000097	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPSea814_000098	COG0484	heat shock protein binding
TPSea814_000100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPSea814_000101	COG0785	Cytochrome C biogenesis protein
TPSea814_000104	COG0737	Belongs to the 5'-nucleotidase family
TPSea814_000105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPSea814_000105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPSea814_000105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPSea814_000107	COG4750	Nucleotidyl transferase
TPSea814_000108	COG0205	6-phosphofructokinase activity
TPSea814_000111	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPSea814_000113	COG0330	HflC and HflK could
TPSea814_000114	COG0330	HflC and HflK could
TPSea814_000115	COG0351	phosphomethylpyrimidine kinase
TPSea814_000116	COG0556	nucleotide-excision repair
TPSea814_000119	COG2011	ABC-type metal ion transport system permease component
TPSea814_000120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPSea814_000121	COG1509	lysine 2,3-aminomutase activity
TPSea814_000122	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TPSea814_000124	COG0012	GTP binding
TPSea814_000125	COG0708	Exodeoxyribonuclease III
TPSea814_000139	COG0569	domain protein
TPSea814_000140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPSea814_000141	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPSea814_000145	COG1022	Amp-dependent synthetase and ligase
TPSea814_000147	COG1449	Belongs to the glycosyl hydrolase 57 family
TPSea814_000153	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TPSea814_000160	COG0442	prolyl-tRNA aminoacylation
TPSea814_000162	COG2255	four-way junction helicase activity
TPSea814_000163	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPSea814_000164	COG1121	(ABC) transporter
TPSea814_000165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSea814_000166	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPSea814_000168	COG0588	phosphoglycerate mutase activity
TPSea814_000170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPSea814_000171	COG4939	FMN-binding domain protein
TPSea814_000180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TPSea814_000184	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPSea814_000186	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPSea814_000187	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPSea814_000188	COG0051	transcription antitermination factor activity, RNA binding
TPSea814_000189	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPSea814_000190	COG0088	Forms part of the polypeptide exit tunnel
TPSea814_000191	COG0089	rRNA binding
TPSea814_000192	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPSea814_000193	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPSea814_000194	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TPSea814_000195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPSea814_000196	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPSea814_000197	COG0255	Belongs to the universal ribosomal protein uL29 family
TPSea814_000198	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPSea814_000199	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPSea814_000200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPSea814_000201	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPSea814_000202	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TPSea814_000203	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPSea814_000204	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPSea814_000205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPSea814_000206	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TPSea814_000207	COG0200	Binds to the 23S rRNA
TPSea814_000210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPSea814_000211	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPSea814_000212	COG0202	RNA polymerase activity
TPSea814_000213	COG0203	ribosomal protein L17
TPSea814_000215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPSea814_000216	COG0443	Heat shock 70 kDa protein
TPSea814_000217	COG0484	heat shock protein binding
TPSea814_000220	COG1366	Belongs to the anti-sigma-factor antagonist family
TPSea814_000227	COG1122	ATPase activity
TPSea814_000228	COG1268	BioY protein
TPSea814_000229	COG1573	uracil-dna glycosylase
TPSea814_000230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPSea814_000231	COG0564	pseudouridine synthase activity
TPSea814_000234	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TPSea814_000235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPSea814_000236	COG0250	Participates in transcription elongation, termination and antitermination
TPSea814_000237	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPSea814_000238	COG0081	regulation of translation
TPSea814_000239	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPSea814_000240	COG0222	ribosome binding
TPSea814_000241	COG0085	RNA polymerase activity
TPSea814_000242	COG0739	heme binding
TPSea814_000242	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPSea814_000243	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPSea814_000244	COG0049	tRNA binding
TPSea814_000245	COG0714	Associated with various cellular activities
TPSea814_000246	COG2304	oxidoreductase activity
TPSea814_000247	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPSea814_000250	COG0776	regulation of translation
TPSea814_000252	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPSea814_000254	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPSea814_000255	COG0254	rRNA binding
TPSea814_000256	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPSea814_000257	COG0584	glycerophosphoryl diester phosphodiesterase
TPSea814_000262	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPSea814_000264	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPSea814_000265	COG1114	Component of the transport system for branched-chain amino acids
TPSea814_000269	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPSea814_000270	COG0617	tRNA 3'-terminal CCA addition
TPSea814_000271	COG1475	DNA binding
TPSea814_000272	COG1192	Involved in chromosome partitioning
TPSea814_000277	COG0793	Belongs to the peptidase S41A family
TPSea814_000282	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TPSea814_000283	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPSea814_000284	COG0731	radical SAM domain protein
TPSea814_000288	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TPSea814_000290	COG0561	phosphatase activity
TPSea814_000292	COG2885	chlorophyll binding
TPSea814_000294	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPSea814_000296	COG0237	dephospho-CoA kinase activity
TPSea814_000298	COG1744	ABC transporter substrate-binding protein PnrA-like
TPSea814_000300	COG3845	ABC transporter
TPSea814_000301	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPSea814_000302	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPSea814_000303	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPSea814_000304	COG0823	Involved in the tonB-independent uptake of proteins
TPSea814_000305	COG0504	CTP synthase activity
TPSea814_000306	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPSea814_000319	COG1744	ABC transporter substrate-binding protein PnrA-like
TPSea814_000324	COG2911	Protein conserved in bacteria
TPSea814_000326	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPSea814_000328	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TPSea814_000329	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPSea814_000331	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TPSea814_000337	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPSea814_000340	COG0285	dihydrofolate synthase activity
TPSea814_000341	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPSea814_000342	COG1102	Psort location Cytoplasmic, score
TPSea814_000345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPSea814_000349	COG1047	Peptidyl-prolyl cis-trans
TPSea814_000350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TPSea814_000351	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TPSea814_000352	COG4443	Transcriptional Coactivator p15 (PC4)
TPSea814_000353	COG0328	RNA-DNA hybrid ribonuclease activity
TPSea814_000354	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPSea814_000358	COG1543	Belongs to the glycosyl hydrolase 57 family
TPSea814_000359	COG3330	Domain of unknown function (DUF4912)
TPSea814_000362	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPSea814_000363	COG2198	Histidine kinase
TPSea814_000363	COG0643	Histidine kinase
TPSea814_000364	COG0835	chemotaxis
TPSea814_000366	COG2201	protein-glutamate methylesterase activity
TPSea814_000367	COG1196	nuclear chromosome segregation
TPSea814_000371	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPSea814_000372	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TPSea814_000373	COG0037	tRNA processing
TPSea814_000374	COG0457	Tetratricopeptide repeat
TPSea814_000379	COG0653	protein targeting
TPSea814_000381	COG5522	Integral membrane protein (intg_mem_TP0381)
TPSea814_000383	COG2001	Belongs to the MraZ family
TPSea814_000384	COG0275	rRNA processing
TPSea814_000386	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPSea814_000388	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPSea814_000390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPSea814_000391	COG4974	Belongs to the 'phage' integrase family
TPSea814_000393	COG0758	DNA mediated transformation
TPSea814_000394	COG0551	DNA topoisomerase type I activity
TPSea814_000394	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPSea814_000396	COG1815	bacterial-type flagellum-dependent cell motility
TPSea814_000398	COG1677	Flagellar hook-basal body complex protein FliE
TPSea814_000401	COG1317	bacterial-type flagellum organization
TPSea814_000402	COG1157	protein secretion by the type III secretion system
TPSea814_000404	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPSea814_000406	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TPSea814_000408a	COG1862	Preprotein translocase
TPSea814_000410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPSea814_000411	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPSea814_000414	COG1115	amino acid carrier protein
TPSea814_000416	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPSea814_000417	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPSea814_000418	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPSea814_000419	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPSea814_000424	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TPSea814_000426	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPSea814_000427	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPSea814_000428	COG1394	ATPase activity, coupled to movement of substances
TPSea814_000429	COG1269	ATP hydrolysis coupled proton transport
TPSea814_000431	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TPSea814_000435	COG3015	lipoprotein NlpE involved in copper resistance
TPSea814_000436	COG1227	inorganic diphosphatase activity
TPSea814_000438	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPSea814_000439	COG0835	chemotaxis
TPSea814_000441	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPSea814_000442	COG0497	DNA recombination
TPSea814_000446	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPSea814_000446a	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPSea814_000447	COG3118	belongs to the thioredoxin family
TPSea814_000448	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPSea814_000449	COG0457	Tetratricopeptide repeat
TPSea814_000450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPSea814_000452	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPSea814_000454	COG3706	GGDEF domain
TPSea814_000458	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPSea814_000464	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPSea814_000472	COG0322	excinuclease ABC activity
TPSea814_000474	COG0217	transcriptional regulatory protein
TPSea814_000475	COG0166	Belongs to the GPI family
TPSea814_000476	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPSea814_000477	COG0363	glucosamine-6-phosphate deaminase activity
TPSea814_000478	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TPSea814_000480	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TPSea814_000481	COG2982	Protein involved in outer membrane biogenesis
TPSea814_000484	COG4254	PFAM FecR protein
TPSea814_000488	COG0840	transmembrane signaling receptor activity
TPSea814_000492	COG0358	DNA primase activity
TPSea814_000493	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPSea814_000497	COG1077	Cell shape determining protein MreB Mrl
TPSea814_000501	COG0772	Belongs to the SEDS family
TPSea814_000502	COG0666	response to abiotic stimulus
TPSea814_000506	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPSea814_000507	COG0740	serine-type endopeptidase activity
TPSea814_000508	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TPSea814_000509	COG0450	alkyl hydroperoxide reductase
TPSea814_000510	COG0481	GTPase activity
TPSea814_000511	COG1329	Transcriptional regulator
TPSea814_000512	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPSea814_000512	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPSea814_000516	COG0728	peptidoglycan biosynthetic process
TPSea814_000517	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPSea814_000519	COG2204	response regulator
TPSea814_000521	COG0470	DNA polymerase III
TPSea814_000522	COG1286	toxin biosynthetic process
TPSea814_000523	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPSea814_000524	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPSea814_000525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPSea814_000527	COG1394	ATPase activity, coupled to movement of substances
TPSea814_000528	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPSea814_000529	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPSea814_000533	COG1269	ATP hydrolysis coupled proton transport
TPSea814_000534	COG1527	subunit (C
TPSea814_000536	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPSea814_000537	COG0149	triose-phosphate isomerase activity
TPSea814_000538	COG0126	phosphoglycerate kinase activity
TPSea814_000540	COG1366	Belongs to the anti-sigma-factor antagonist family
TPSea814_000541	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TPSea814_000542	COG0205	6-phosphofructokinase activity
TPSea814_000543	COG0632	four-way junction helicase activity
TPSea814_000546	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPSea814_000547	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TPSea814_000550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TPSea814_000553	COG0628	permease
TPSea814_000554	COG0546	phosphoglycolate phosphatase activity
TPSea814_000556	COG2502	aspartate--ammonia ligase
TPSea814_000559	COG0301	tRNA thio-modification
TPSea814_000560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TPSea814_000561	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TPSea814_000562	COG2089	acid synthase
TPSea814_000568	COG0800	Aldolase
TPSea814_000569	COG0006	proline dipeptidase activity
TPSea814_000572	COG3976	FMN-binding domain protein
TPSea814_000572	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TPSea814_000574b	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPSea814_000576	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPSea814_000578	COG0552	protein localization to endoplasmic reticulum
TPSea814_000580	COG4591	ABC-type transport system involved in lipoprotein release permease component
TPSea814_000581	COG1136	(ABC) transporter
TPSea814_000585	COG4166	transmembrane transport
TPSea814_000586	COG0495	leucyl-tRNA aminoacylation
TPSea814_000588	COG1466	dna polymerase III delta subunit
TPSea814_000589	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSea814_000591	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TPSea814_000593	COG3064	Membrane
TPSea814_000595	COG0563	adenylate kinase activity
TPSea814_000596	COG0617	tRNA 3'-terminal CCA addition
TPSea814_000600	COG0750	zinc metalloprotease
TPSea814_000601	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPSea814_000602	COG0575	Belongs to the CDS family
TPSea814_000603	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPSea814_000604	COG0233	cytoplasmic translational termination
TPSea814_000605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPSea814_000606	COG0052	Belongs to the universal ribosomal protein uS2 family
TPSea814_000608	COG1413	lyase activity
TPSea814_000609	COG0017	Asparaginyl-tRNA synthetase
TPSea814_000612	COG0719	Fe-S assembly protein
TPSea814_000613	COG0719	Fe-S assembly protein
TPSea814_000614	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPSea814_000616	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TPSea814_000623	COG0741	lytic transglycosylase activity
TPSea814_000623	COG1388	LysM domain
TPSea814_000628	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPSea814_000631	COG2201	protein-glutamate methylesterase activity
TPSea814_000632	COG0180	Tryptophanyl-tRNA synthetase
TPSea814_000633	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPSea814_000633	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPSea814_000634	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPSea814_000637	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPSea814_000639	COG3290	protein histidine kinase activity
TPSea814_000639	COG0840	transmembrane signaling receptor activity
TPSea814_000640	COG0840	transmembrane signaling receptor activity
TPSea814_000641	COG0124	histidyl-tRNA synthetase
TPSea814_000642	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPSea814_000643	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPSea814_000644	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPSea814_000645	COG1177	transmembrane transport
TPSea814_000647	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPSea814_000650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPSea814_000652	COG3842	ATPase activity
TPSea814_000653	COG1176	ABC-type spermidine putrescine transport system, permease component I
TPSea814_000657	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TPSea814_000658	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TPSea814_000662	COG0191	fructose-bisphosphate aldolase activity
TPSea814_000667	COG0572	uridine kinase
TPSea814_000669	COG0587	DNA-directed DNA polymerase activity
TPSea814_000670	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPSea814_000672	COG0423	glycine-tRNA ligase activity
TPSea814_000673	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPSea814_000674	COG2840	Smr protein MutS2
TPSea814_000675	COG3735	TraB family
TPSea814_000678	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPSea814_000680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPSea814_000681	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPSea814_000682	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TPSea814_000683	COG0142	geranyltranstransferase activity
TPSea814_000684	COG1879	ABC-type sugar transport system periplasmic component
TPSea814_000685	COG1129	ABC transporter
TPSea814_000686	COG4211	Belongs to the binding-protein-dependent transport system permease family
TPSea814_000687	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPSea814_000688	COG1619	proteins homologs of microcin C7 resistance protein MccF
TPSea814_000689	COG1160	GTP binding
TPSea814_000692	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPSea814_000695	COG0151	Belongs to the GarS family
TPSea814_000703	COG0739	heme binding
TPSea814_000704	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPSea814_000704	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPSea814_000706	COG0739	heme binding
TPSea814_000706	COG1196	nuclear chromosome segregation
TPSea814_000706	COG0741	lytic transglycosylase activity
TPSea814_000709	COG1191	sigma factor activity
TPSea814_000712	COG0455	bacterial-type flagellum organization
TPSea814_000714	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPSea814_000715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPSea814_000717	COG1987	bacterial-type flagellum assembly
TPSea814_000718	COG1338	Plays a role in the flagellum-specific transport system
TPSea814_000720	COG1776	CheC inhibitor of MCP methylation
TPSea814_000720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSea814_000721	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPSea814_000722	COG1580	Controls the rotational direction of flagella during chemotaxis
TPSea814_000724	COG1360	Flagellar Motor Protein
TPSea814_000725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TPSea814_000727	COG1749	Flagellar hook protein flgE
TPSea814_000728	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPSea814_000732	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPSea814_000734	COG0813	purine-nucleoside phosphorylase activity
TPSea814_000735	COG0493	'glutamate synthase
TPSea814_000736	COG0543	2 iron, 2 sulfur cluster binding
TPSea814_000738	COG0799	negative regulation of ribosome biogenesis
TPSea814_000741	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPSea814_000742	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPSea814_000743	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPSea814_000745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TPSea814_000746	COG0574	Belongs to the PEP-utilizing enzyme family
TPSea814_000746	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPSea814_000750	COG2304	oxidoreductase activity
TPSea814_000754	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPSea814_000755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSea814_000755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPSea814_000755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPSea814_000756	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPSea814_000757	COG0242	peptide deformylase activity
TPSea814_000758	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TPSea814_000760	COG0768	penicillin binding
TPSea814_000761	COG2604	Protein of unknown function DUF115
TPSea814_000762	COG2604	Protein of unknown function DUF115
TPSea814_000765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPSea814_000767	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPSea814_000769	COG1652	LysM domain
TPSea814_000773	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPSea814_000774	COG1285	pathogenesis
TPSea814_000775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPSea814_000778	COG3956	TIGRFAM MazG family protein
TPSea814_000780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPSea814_000780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPSea814_000782	COG0739	heme binding
TPSea814_000786	COG1137	ATPase activity
TPSea814_000789	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TPSea814_000792	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSea814_000794	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPSea814_000796	COG1477	protein flavinylation
TPSea814_000797	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPSea814_000800	COG1686	Belongs to the peptidase S11 family
TPSea814_000801	COG0542	response to heat
TPSea814_000804	COG3842	ATPase activity
TPSea814_000805	COG0557	exoribonuclease II activity
TPSea814_000807	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TPSea814_000808	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPSea814_000809	COG0571	ribonuclease III activity
TPSea814_000810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TPSea814_000814	COG0492	ferredoxin-NADP+ reductase activity
TPSea814_000817	COG0148	phosphopyruvate hydratase activity
TPSea814_000819	COG1234	tRNA 3'-trailer cleavage
TPSea814_000821	COG1464	Belongs to the NlpA lipoprotein family
TPSea814_000822	COG0668	transmembrane transport
TPSea814_000823	COG2033	superoxide reductase activity
TPSea814_000824	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPSea814_000828	COG0736	holo-[acyl-carrier-protein] synthase activity
TPSea814_000830	COG0101	tRNA pseudouridine synthase activity
TPSea814_000831	COG0018	arginyl-trna synthetase
TPSea814_000834	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPSea814_000837	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPSea814_000838	COG0488	(ABC) transporter
TPSea814_000841	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPSea814_000842	COG0024	Methionine aminopeptidase
TPSea814_000844	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPSea814_000845	COG1671	Belongs to the UPF0178 family
TPSea814_000846	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPSea814_000848	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPSea814_000849	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPSea814_000850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TPSea814_000851	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPSea814_000852	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPSea814_000853	COG0455	bacterial-type flagellum organization
TPSea814_000861	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPSea814_000862	COG0545	Peptidyl-prolyl cis-trans isomerase
TPSea814_000863	COG1104	cysteine desulfurase activity
TPSea814_000864	COG3942	CHAP domain
TPSea814_000864	COG1388	LysM domain
TPSea814_000865a	COG0606	chelatase, subunit chli
TPSea814_000868	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSea814_000870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPSea814_000875	COG0802	atpase or kinase
TPSea814_000876	COG1214	PFAM Peptidase M22, glycoprotease
TPSea814_000877	COG2770	Histidine kinase
TPSea814_000877	COG3437	response regulator, receiver
TPSea814_000881	COG4555	ABC transporter
TPSea814_000885	COG0756	dUTP diphosphatase activity
TPSea814_000886	COG1185	polyribonucleotide nucleotidyltransferase activity
TPSea814_000887	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPSea814_000889	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPSea814_000890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPSea814_000891	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPSea814_000893	COG0779	Required for maturation of 30S ribosomal subunits
TPSea814_000901	COG0534	Mate efflux family protein
TPSea814_000903	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPSea814_000905	COG0228	four-way junction DNA binding
TPSea814_000906	COG1837	Belongs to the UPF0109 family
TPSea814_000907	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPSea814_000908	COG0336	Belongs to the RNA methyltransferase TrmD family
TPSea814_000909	COG0335	large ribosomal subunit rRNA binding
TPSea814_000911	COG2257	FlhB HrpN YscU SpaS Family
TPSea814_000913	COG0792	nuclease activity
TPSea814_000917	COG2239	Acts as a magnesium transporter
TPSea814_000919	COG3118	belongs to the thioredoxin family
TPSea814_000920	COG0457	Tetratricopeptide repeat
TPSea814_000925	COG0716	FMN binding
TPSea814_000926	COG0681	Belongs to the peptidase S26 family
TPSea814_000928	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPSea814_000930	COG2604	Protein of unknown function DUF115
TPSea814_000933	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPSea814_000936	COG1253	flavin adenine dinucleotide binding
TPSea814_000945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPSea814_000946	COG0357	Ribosomal RNA small subunit methyltransferase G
TPSea814_000947	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TPSea814_000948	COG1847	R3H domain protein
TPSea814_000949	COG0706	membrane insertase activity
TPSea814_000949a	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TPSea814_000951	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TPSea814_000959	COG3951	Flagellar rod assembly protein muramidase FlgJ
TPSea814_000963	COG1136	(ABC) transporter
TPSea814_000963	COG0577	efflux transmembrane transporter activity
TPSea814_000964	COG1136	(ABC) transporter
TPSea814_000965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPSea814_000971	COG3470	protein probably involved in high-affinity Fe2 transport
TPSea814_000972	COG0672	)-iron permease
TPSea814_000973	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPSea814_000975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPSea814_000977	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPSea814_000978	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPSea814_000979	COG0084	hydrolase, TatD family'
TPSea814_000980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPSea814_000980	COG3116	cell division
TPSea814_000981	COG3706	GGDEF domain
TPSea814_000981	COG0745	RESPONSE REGULATOR receiver
TPSea814_000984	COG0326	Molecular chaperone. Has ATPase activity
TPSea814_000985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPSea814_000988	COG2095	MarC family integral membrane protein
TPSea814_000991	COG1773	rubredoxin
TPSea814_000993	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TPSea814_000994	COG0084	hydrolase, TatD family'
TPSea814_000997	COG0616	signal peptide processing
TPSea814_000998	COG1115	amino acid carrier protein
TPSea814_000999	COG1674	ftsk spoiiie
TPSea814_001004	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPSea814_001005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPSea814_001006	COG0187	DNA topoisomerase II activity
TPSea814_001007	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TPSea814_001008	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPSea814_001009	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPSea814_001010	COG0105	UTP biosynthetic process
TPSea814_001011	COG0193	aminoacyl-tRNA hydrolase activity
TPSea814_001012	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPSea814_001013	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPSea814_001015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPSea814_001016	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPSea814_001017	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPSea814_001018	COG1418	mRNA catabolic process
TPSea814_001019	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPSea814_001020	COG0154	amidase activity
TPSea814_001021	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPSea814_001022	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPSea814_001023	COG2137	regulation of response to DNA damage stimulus
TPSea814_001024	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TPSea814_001025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPSea814_001027	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TPSea814_001029	COG0724	RNA recognition motif
TPSea814_001032	COG5341	Protein conserved in bacteria
TPSea814_001033	COG1752	Esterase of the alpha-beta hydrolase superfamily
TPSea814_001034	COG0530	calcium, potassium:sodium antiporter activity
TPSea814_001035	COG0525	valine-tRNA ligase activity
TPSea814_001037	COG1272	protein, Hemolysin III
TPSea814_001038	COG0783	Belongs to the Dps family
TPSea814_001039	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TPSea814_001040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TPSea814_001041	COG0740	serine-type endopeptidase activity