locus-tag	class	description
TPCCA_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPCCA_0002	COG0592	DNA-directed DNA polymerase activity
TPCCA_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPCCA_0004	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TPCCA_0005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPCCA_0006	COG1609	Transcriptional regulator
TPCCA_0013	COG1609	Transcriptional regulator
TPCCA_0015	COG0072	phenylalanine-tRNA ligase activity
TPCCA_0016	COG1067	ATP-dependent peptidase activity
TPCCA_0018	COG1747	RNA polymerase binding
TPCCA_0018	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPCCA_0023	COG0733	neurotransmitter:sodium symporter activity
TPCCA_0026	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPCCA_0028	COG1253	flavin adenine dinucleotide binding
TPCCA_0029	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPCCA_0030	COG0459	protein refolding
TPCCA_0032	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPCCA_0034	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPCCA_0035	COG1121	(ABC) transporter
TPCCA_0036	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPCCA_0037	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPCCA_0042	COG1652	LysM domain
TPCCA_0044	COG0445	tRNA wobble uridine modification
TPCCA_0045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TPCCA_0046	COG1774	PSP1 C-terminal conserved region
TPCCA_0049	COG0739	heme binding
TPCCA_0052	COG2890	protein-(glutamine-N5) methyltransferase activity
TPCCA_0053	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPCCA_0055	COG3630	sodium ion export across plasma membrane
TPCCA_0057	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TPCCA_0058	COG0305	Participates in initiation and elongation during chromosome replication
TPCCA_0060	COG0359	binds to the 23S rRNA
TPCCA_0061	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPCCA_0062	COG0629	single-stranded DNA binding
TPCCA_0063	COG0360	Binds together with S18 to 16S ribosomal RNA
TPCCA_0068	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPCCA_0071	COG0542	response to heat
TPCCA_0073	COG1639	'signal transduction protein
TPCCA_0076	COG0395	ABC-type sugar transport system, permease component
TPCCA_0078	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPCCA_0081	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TPCCA_0082	COG3604	Transcriptional regulator
TPCCA_0085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPCCA_0085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPCCA_0085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPCCA_0089	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPCCA_0090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPCCA_0091	COG0215	cysteine-tRNA ligase activity
TPCCA_0094	COG0280	phosphate acetyltransferase
TPCCA_0095	COG0457	Tetratricopeptide repeat
TPCCA_0097	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPCCA_0098	COG0484	heat shock protein binding
TPCCA_0100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPCCA_0101	COG0785	Cytochrome C biogenesis protein
TPCCA_0104	COG0737	Belongs to the 5'-nucleotidase family
TPCCA_0105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPCCA_0105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPCCA_0105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPCCA_0107	COG4750	Nucleotidyl transferase
TPCCA_0108	COG0205	6-phosphofructokinase activity
TPCCA_0111	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPCCA_0112	COG3579	cysteine-type endopeptidase activity
TPCCA_0113	COG0330	HflC and HflK could
TPCCA_0114	COG0330	HflC and HflK could
TPCCA_0115	COG0351	phosphomethylpyrimidine kinase
TPCCA_0116	COG0556	nucleotide-excision repair
TPCCA_0119	COG2011	ABC-type metal ion transport system permease component
TPCCA_0120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPCCA_0121	COG1509	lysine 2,3-aminomutase activity
TPCCA_0122	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TPCCA_0123	COG0457	Tetratricopeptide repeat
TPCCA_0124	COG0012	GTP binding
TPCCA_0125	COG0708	Exodeoxyribonuclease III
TPCCA_0139	COG0569	domain protein
TPCCA_0140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPCCA_0141	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPCCA_0145	COG1022	Amp-dependent synthetase and ligase
TPCCA_0147	COG1449	Belongs to the glycosyl hydrolase 57 family
TPCCA_0153	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TPCCA_0160	COG0442	prolyl-tRNA aminoacylation
TPCCA_0162	COG2255	four-way junction helicase activity
TPCCA_0163	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPCCA_0164	COG1121	(ABC) transporter
TPCCA_0165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPCCA_0166	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPCCA_0168	COG0588	phosphoglycerate mutase activity
TPCCA_0170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPCCA_0171	COG4939	FMN-binding domain protein
TPCCA_0172	COG2199	diguanylate cyclase activity
TPCCA_0181	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TPCCA_0184	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPCCA_0186	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPCCA_0187	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPCCA_0188	COG0051	transcription antitermination factor activity, RNA binding
TPCCA_0189	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPCCA_0190	COG0088	Forms part of the polypeptide exit tunnel
TPCCA_0191	COG0089	rRNA binding
TPCCA_0192	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPCCA_0193	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPCCA_0194	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TPCCA_0195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPCCA_0196	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPCCA_0197	COG0255	Belongs to the universal ribosomal protein uL29 family
TPCCA_0198	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPCCA_0199	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPCCA_0200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPCCA_0201	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPCCA_0203	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPCCA_0204	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPCCA_0205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPCCA_0206	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TPCCA_0207	COG0200	Binds to the 23S rRNA
TPCCA_0210	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPCCA_0211	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPCCA_0212	COG0202	RNA polymerase activity
TPCCA_0213	COG0203	ribosomal protein L17
TPCCA_0215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPCCA_0216	COG0443	Heat shock 70 kDa protein
TPCCA_0217	COG0484	heat shock protein binding
TPCCA_0220	COG1366	Belongs to the anti-sigma-factor antagonist family
TPCCA_0227	COG1122	ATPase activity
TPCCA_0228	COG1268	BioY protein
TPCCA_0229	COG1573	uracil-dna glycosylase
TPCCA_0230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPCCA_0231	COG0564	pseudouridine synthase activity
TPCCA_0234	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TPCCA_0235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPCCA_0236	COG0250	Participates in transcription elongation, termination and antitermination
TPCCA_0237	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPCCA_0238	COG0081	regulation of translation
TPCCA_0239	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPCCA_0240	COG0222	ribosome binding
TPCCA_0241	COG0085	RNA polymerase activity
TPCCA_0242	COG0739	heme binding
TPCCA_0242	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPCCA_0243	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPCCA_0244	COG0049	tRNA binding
TPCCA_0245	COG0714	Associated with various cellular activities
TPCCA_0246	COG2304	oxidoreductase activity
TPCCA_0247	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPCCA_0252	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPCCA_0254	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPCCA_0255	COG0254	rRNA binding
TPCCA_0256	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPCCA_0257	COG0584	glycerophosphoryl diester phosphodiesterase
TPCCA_0262	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPCCA_0264	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPCCA_0265	COG1114	Component of the transport system for branched-chain amino acids
TPCCA_0269	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPCCA_0270	COG0617	tRNA 3'-terminal CCA addition
TPCCA_0271	COG1475	DNA binding
TPCCA_0272	COG1192	Involved in chromosome partitioning
TPCCA_0277	COG0793	Belongs to the peptidase S41A family
TPCCA_0282	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TPCCA_0283	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPCCA_0284	COG0731	radical SAM domain protein
TPCCA_0288	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TPCCA_0290	COG0561	phosphatase activity
TPCCA_0292	COG2885	chlorophyll binding
TPCCA_0294	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPCCA_0296	COG0237	dephospho-CoA kinase activity
TPCCA_0298	COG1744	ABC transporter substrate-binding protein PnrA-like
TPCCA_0300	COG3845	ABC transporter
TPCCA_0301	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPCCA_0302	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPCCA_0303	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPCCA_0304	COG0823	Involved in the tonB-independent uptake of proteins
TPCCA_0305	COG0504	CTP synthase activity
TPCCA_0306	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPCCA_0319	COG1744	ABC transporter substrate-binding protein PnrA-like
TPCCA_0324	COG2911	Protein conserved in bacteria
TPCCA_0326	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPCCA_0328	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TPCCA_0329	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPCCA_0331	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TPCCA_0337	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPCCA_0340	COG0285	dihydrofolate synthase activity
TPCCA_0341	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPCCA_0342	COG1102	Psort location Cytoplasmic, score
TPCCA_0345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPCCA_0349	COG1047	Peptidyl-prolyl cis-trans
TPCCA_0350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TPCCA_0351	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TPCCA_0352	COG4443	Transcriptional Coactivator p15 (PC4)
TPCCA_0353	COG0328	RNA-DNA hybrid ribonuclease activity
TPCCA_0354	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPCCA_0358	COG1543	Belongs to the glycosyl hydrolase 57 family
TPCCA_0359	COG3330	Domain of unknown function (DUF4912)
TPCCA_0362	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPCCA_0363	COG0643	Histidine kinase
TPCCA_0363	COG2198	Histidine kinase
TPCCA_0364	COG0835	chemotaxis
TPCCA_0366	COG2201	protein-glutamate methylesterase activity
TPCCA_0367	COG1196	nuclear chromosome segregation
TPCCA_0369	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPCCA_0371	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPCCA_0372	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TPCCA_0373	COG0037	tRNA processing
TPCCA_0374	COG0457	Tetratricopeptide repeat
TPCCA_0379	COG0653	protein targeting
TPCCA_0381	COG5522	Integral membrane protein (intg_mem_TP0381)
TPCCA_0383	COG2001	Belongs to the MraZ family
TPCCA_0384	COG0275	rRNA processing
TPCCA_0386	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPCCA_0388	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPCCA_0390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPCCA_0391	COG4974	Belongs to the 'phage' integrase family
TPCCA_0393	COG0758	DNA mediated transformation
TPCCA_0394	COG0551	DNA topoisomerase type I activity
TPCCA_0394	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPCCA_0395	COG4974	Belongs to the 'phage' integrase family
TPCCA_0396	COG1815	bacterial-type flagellum-dependent cell motility
TPCCA_0398	COG1677	Flagellar hook-basal body complex protein FliE
TPCCA_0399	COG1766	The M ring may be actively involved in energy transduction
TPCCA_0401	COG1317	bacterial-type flagellum organization
TPCCA_0402	COG1157	protein secretion by the type III secretion system
TPCCA_0404	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPCCA_0406	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TPCCA_0409a	COG1862	Preprotein translocase
TPCCA_0410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPCCA_0411	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPCCA_0414	COG1115	amino acid carrier protein
TPCCA_0416	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPCCA_0417	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPCCA_0418	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPCCA_0419	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPCCA_0424	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TPCCA_0426	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPCCA_0427	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPCCA_0428	COG1394	ATPase activity, coupled to movement of substances
TPCCA_0429	COG1269	ATP hydrolysis coupled proton transport
TPCCA_0431	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TPCCA_0435	COG3015	lipoprotein NlpE involved in copper resistance
TPCCA_0436	COG1227	inorganic diphosphatase activity
TPCCA_0438	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPCCA_0439	COG0835	chemotaxis
TPCCA_0441	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPCCA_0442	COG0497	DNA recombination
TPCCA_0446	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPCCA_0447	COG3118	belongs to the thioredoxin family
TPCCA_0448	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPCCA_0449	COG0457	Tetratricopeptide repeat
TPCCA_0450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPCCA_0452	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPCCA_0454	COG3706	GGDEF domain
TPCCA_0458	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPCCA_0464	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPCCA_0472	COG0322	excinuclease ABC activity
TPCCA_0474	COG0217	transcriptional regulatory protein
TPCCA_0475	COG0166	Belongs to the GPI family
TPCCA_0476	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPCCA_0477	COG0363	glucosamine-6-phosphate deaminase activity
TPCCA_0478	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TPCCA_0480	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TPCCA_0481	COG2982	Protein involved in outer membrane biogenesis
TPCCA_0484	COG4254	PFAM FecR protein
TPCCA_0487	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPCCA_0491	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPCCA_0492	COG0358	DNA primase activity
TPCCA_0493	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPCCA_0497	COG1077	Cell shape determining protein MreB Mrl
TPCCA_0500	COG0768	penicillin binding
TPCCA_0501	COG0772	Belongs to the SEDS family
TPCCA_0502	COG0666	response to abiotic stimulus
TPCCA_0506	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPCCA_0507	COG0740	serine-type endopeptidase activity
TPCCA_0508	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TPCCA_0509	COG0450	alkyl hydroperoxide reductase
TPCCA_0510	COG0481	GTPase activity
TPCCA_0511	COG1329	Transcriptional regulator
TPCCA_0512	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPCCA_0512	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPCCA_0514	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPCCA_0516	COG0728	peptidoglycan biosynthetic process
TPCCA_0517	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPCCA_0519	COG2204	response regulator
TPCCA_0520	COG3852	Histidine kinase
TPCCA_0521	COG0470	DNA polymerase III
TPCCA_0522	COG1286	toxin biosynthetic process
TPCCA_0523	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPCCA_0524	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPCCA_0525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPCCA_0527	COG1394	ATPase activity, coupled to movement of substances
TPCCA_0528	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPCCA_0529	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPCCA_0533	COG1269	ATP hydrolysis coupled proton transport
TPCCA_0534	COG1527	subunit (C
TPCCA_0536	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPCCA_0537	COG0149	triose-phosphate isomerase activity
TPCCA_0538	COG0126	phosphoglycerate kinase activity
TPCCA_0540	COG1366	Belongs to the anti-sigma-factor antagonist family
TPCCA_0541	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TPCCA_0542	COG0205	6-phosphofructokinase activity
TPCCA_0543	COG0632	four-way junction helicase activity
TPCCA_0546	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPCCA_0547	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TPCCA_0550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TPCCA_0553	COG0628	permease
TPCCA_0554	COG0546	phosphoglycolate phosphatase activity
TPCCA_0556	COG2502	aspartate--ammonia ligase
TPCCA_0560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TPCCA_0561	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TPCCA_0562	COG2089	acid synthase
TPCCA_0568	COG0800	Aldolase
TPCCA_0569	COG0006	proline dipeptidase activity
TPCCA_0572	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TPCCA_0572	COG3976	FMN-binding domain protein
TPCCA_0575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPCCA_0576	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPCCA_0578	COG0552	protein localization to endoplasmic reticulum
TPCCA_0580	COG4591	ABC-type transport system involved in lipoprotein release permease component
TPCCA_0581	COG1136	(ABC) transporter
TPCCA_0585	COG4166	transmembrane transport
TPCCA_0586	COG0495	leucyl-tRNA aminoacylation
TPCCA_0587	COG1466	dna polymerase III delta subunit
TPCCA_0589	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPCCA_0591	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TPCCA_0593	COG3064	Membrane
TPCCA_0595	COG0563	adenylate kinase activity
TPCCA_0596	COG0617	tRNA 3'-terminal CCA addition
TPCCA_0600	COG0750	zinc metalloprotease
TPCCA_0601	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPCCA_0602	COG0575	Belongs to the CDS family
TPCCA_0603	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPCCA_0604	COG0233	cytoplasmic translational termination
TPCCA_0605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPCCA_0606	COG0052	Belongs to the universal ribosomal protein uS2 family
TPCCA_0608	COG1413	lyase activity
TPCCA_0609	COG0017	Asparaginyl-tRNA synthetase
TPCCA_0612	COG0719	Fe-S assembly protein
TPCCA_0613	COG0719	Fe-S assembly protein
TPCCA_0614	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPCCA_0616	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TPCCA_0623	COG0741	lytic transglycosylase activity
TPCCA_0623	COG1388	LysM domain
TPCCA_0626	COG0420	3'-5' exonuclease activity
TPCCA_0627	COG0419	ATPase involved in DNA repair
TPCCA_0628	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPCCA_0631	COG2201	protein-glutamate methylesterase activity
TPCCA_0632	COG0180	Tryptophanyl-tRNA synthetase
TPCCA_0633	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPCCA_0633	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPCCA_0634	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPCCA_0637	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPCCA_0639	COG3290	protein histidine kinase activity
TPCCA_0639	COG0840	transmembrane signaling receptor activity
TPCCA_0640	COG5278	phosphoserine phosphatase activity
TPCCA_0640	COG0840	transmembrane signaling receptor activity
TPCCA_0641	COG0124	histidyl-tRNA synthetase
TPCCA_0642	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPCCA_0643	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPCCA_0644	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPCCA_0647	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPCCA_0650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPCCA_0651	COG1480	7TM receptor with intracellular HD hydrolase
TPCCA_0652	COG3842	ATPase activity
TPCCA_0653	COG1176	ABC-type spermidine putrescine transport system, permease component I
TPCCA_0654	COG1177	transmembrane transport
TPCCA_0657	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TPCCA_0658	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TPCCA_0662	COG0191	fructose-bisphosphate aldolase activity
TPCCA_0667	COG0572	uridine kinase
TPCCA_0669	COG0587	DNA-directed DNA polymerase activity
TPCCA_0670	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPCCA_0672	COG0423	glycine-tRNA ligase activity
TPCCA_0673	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPCCA_0674	COG2840	Smr protein MutS2
TPCCA_0675	COG3735	TraB family
TPCCA_0678	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPCCA_0680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPCCA_0681	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPCCA_0682	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TPCCA_0683	COG0142	geranyltranstransferase activity
TPCCA_0684	COG1879	ABC-type sugar transport system periplasmic component
TPCCA_0685	COG1129	ABC transporter
TPCCA_0686	COG4211	Belongs to the binding-protein-dependent transport system permease family
TPCCA_0687	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPCCA_0688	COG1619	proteins homologs of microcin C7 resistance protein MccF
TPCCA_0689	COG1160	GTP binding
TPCCA_0692	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPCCA_0695	COG0151	Belongs to the GarS family
TPCCA_0702	COG0739	heme binding
TPCCA_0704	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPCCA_0704	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPCCA_0706	COG0739	heme binding
TPCCA_0706	COG1196	nuclear chromosome segregation
TPCCA_0706	COG0741	lytic transglycosylase activity
TPCCA_0709	COG1191	sigma factor activity
TPCCA_0712	COG0455	bacterial-type flagellum organization
TPCCA_0713	COG1419	protein localization to endoplasmic reticulum
TPCCA_0714	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPCCA_0715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPCCA_0716	COG1684	flagellar biosynthetic protein fliR
TPCCA_0717	COG1987	bacterial-type flagellum assembly
TPCCA_0718	COG1338	Plays a role in the flagellum-specific transport system
TPCCA_0720	COG1776	CheC inhibitor of MCP methylation
TPCCA_0720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPCCA_0721	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPCCA_0722	COG1580	Controls the rotational direction of flagella during chemotaxis
TPCCA_0724	COG1360	Flagellar Motor Protein
TPCCA_0725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TPCCA_0727	COG1749	Flagellar hook protein flgE
TPCCA_0728	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPCCA_0732	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPCCA_0734	COG0813	purine-nucleoside phosphorylase activity
TPCCA_0735	COG0493	'glutamate synthase
TPCCA_0736	COG0543	2 iron, 2 sulfur cluster binding
TPCCA_0738	COG0799	negative regulation of ribosome biogenesis
TPCCA_0741	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPCCA_0742	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPCCA_0743	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPCCA_0745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TPCCA_0746	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPCCA_0746	COG0574	Belongs to the PEP-utilizing enzyme family
TPCCA_0750	COG2304	oxidoreductase activity
TPCCA_0754	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPCCA_0755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPCCA_0755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPCCA_0755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPCCA_0756	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPCCA_0757	COG0242	peptide deformylase activity
TPCCA_0758	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TPCCA_0760	COG0768	penicillin binding
TPCCA_0761	COG2604	Protein of unknown function DUF115
TPCCA_0762	COG2604	Protein of unknown function DUF115
TPCCA_0765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPCCA_0767	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPCCA_0769	COG1652	LysM domain
TPCCA_0773	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPCCA_0774	COG1285	pathogenesis
TPCCA_0775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPCCA_0778	COG3956	TIGRFAM MazG family protein
TPCCA_0780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPCCA_0780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPCCA_0781	COG0739	heme binding
TPCCA_0786	COG1137	ATPase activity
TPCCA_0789	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TPCCA_0792	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPCCA_0794	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPCCA_0796	COG1477	protein flavinylation
TPCCA_0797	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPCCA_0798	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPCCA_0798	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPCCA_0800	COG1686	Belongs to the peptidase S11 family
TPCCA_0801	COG0542	response to heat
TPCCA_0804	COG3842	ATPase activity
TPCCA_0805	COG0557	exoribonuclease II activity
TPCCA_0807	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TPCCA_0808	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPCCA_0809	COG0571	ribonuclease III activity
TPCCA_0810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TPCCA_0814	COG0492	ferredoxin-NADP+ reductase activity
TPCCA_0817	COG0148	phosphopyruvate hydratase activity
TPCCA_0819	COG1234	tRNA 3'-trailer cleavage
TPCCA_0821	COG1464	Belongs to the NlpA lipoprotein family
TPCCA_0822	COG0668	transmembrane transport
TPCCA_0823	COG2033	superoxide reductase activity
TPCCA_0824	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPCCA_0828	COG0736	holo-[acyl-carrier-protein] synthase activity
TPCCA_0830	COG0101	tRNA pseudouridine synthase activity
TPCCA_0831	COG0018	arginyl-trna synthetase
TPCCA_0834	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPCCA_0837	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPCCA_0838	COG0488	(ABC) transporter
TPCCA_0841	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPCCA_0842	COG0024	Methionine aminopeptidase
TPCCA_0844	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPCCA_0845	COG1671	Belongs to the UPF0178 family
TPCCA_0846	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPCCA_0848	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPCCA_0849	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPCCA_0850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TPCCA_0851	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPCCA_0852	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPCCA_0853	COG0455	bacterial-type flagellum organization
TPCCA_0861	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPCCA_0862	COG0545	Peptidyl-prolyl cis-trans isomerase
TPCCA_0863	COG1104	cysteine desulfurase activity
TPCCA_0864	COG1388	LysM domain
TPCCA_0864	COG3942	CHAP domain
TPCCA_0866	COG0606	chelatase, subunit chli
TPCCA_0868	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPCCA_0870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPCCA_0872	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TPCCA_0872	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPCCA_0875	COG0802	atpase or kinase
TPCCA_0876	COG1214	PFAM Peptidase M22, glycoprotease
TPCCA_0877	COG2770	Histidine kinase
TPCCA_0877	COG3437	response regulator, receiver
TPCCA_0881	COG4555	ABC transporter
TPCCA_0885	COG0756	dUTP diphosphatase activity
TPCCA_0886	COG1185	polyribonucleotide nucleotidyltransferase activity
TPCCA_0887	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPCCA_0889	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPCCA_0890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPCCA_0891	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPCCA_0893	COG0779	Required for maturation of 30S ribosomal subunits
TPCCA_0899	COG2887	Belongs to the helicase family. UvrD subfamily
TPCCA_0901	COG0534	Mate efflux family protein
TPCCA_0903	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPCCA_0905	COG0228	four-way junction DNA binding
TPCCA_0906	COG1837	Belongs to the UPF0109 family
TPCCA_0907	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPCCA_0908	COG0336	Belongs to the RNA methyltransferase TrmD family
TPCCA_0909	COG0335	large ribosomal subunit rRNA binding
TPCCA_0911	COG2257	FlhB HrpN YscU SpaS Family
TPCCA_0913	COG0792	nuclease activity
TPCCA_0917	COG2239	Acts as a magnesium transporter
TPCCA_0919	COG3118	belongs to the thioredoxin family
TPCCA_0920	COG0457	Tetratricopeptide repeat
TPCCA_0924	COG2183	response to ionizing radiation
TPCCA_0925	COG0716	FMN binding
TPCCA_0926	COG0681	Belongs to the peptidase S26 family
TPCCA_0928	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPCCA_0930	COG2604	Protein of unknown function DUF115
TPCCA_0933	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPCCA_0936	COG1253	flavin adenine dinucleotide binding
TPCCA_0945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPCCA_0946	COG0357	Ribosomal RNA small subunit methyltransferase G
TPCCA_0947	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TPCCA_0948	COG1847	R3H domain protein
TPCCA_0949	COG0706	membrane insertase activity
TPCCA_0949a	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TPCCA_0951	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TPCCA_0959	COG3951	Flagellar rod assembly protein muramidase FlgJ
TPCCA_0961	COG4786	Flagellar basal body rod
TPCCA_0963	COG1136	(ABC) transporter
TPCCA_0963	COG0577	efflux transmembrane transporter activity
TPCCA_0964	COG1136	(ABC) transporter
TPCCA_0965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TPCCA_0971	COG3470	protein probably involved in high-affinity Fe2 transport
TPCCA_0972	COG0672	)-iron permease
TPCCA_0973	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPCCA_0975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPCCA_0977	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPCCA_0978	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPCCA_0979	COG0084	hydrolase, TatD family'
TPCCA_0980	COG3116	cell division
TPCCA_0980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPCCA_0981	COG3706	GGDEF domain
TPCCA_0981	COG0745	RESPONSE REGULATOR receiver
TPCCA_0984	COG0326	Molecular chaperone. Has ATPase activity
TPCCA_0985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPCCA_0988	COG2095	MarC family integral membrane protein
TPCCA_0991	COG1773	rubredoxin
TPCCA_0993	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TPCCA_0994	COG0084	hydrolase, TatD family'
TPCCA_0997	COG0616	signal peptide processing
TPCCA_0998	COG1115	amino acid carrier protein
TPCCA_0999	COG1674	ftsk spoiiie
TPCCA_1004	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPCCA_1005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPCCA_1006	COG0187	DNA topoisomerase II activity
TPCCA_1007	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TPCCA_1008	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPCCA_1009	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPCCA_1010	COG0105	UTP biosynthetic process
TPCCA_1011	COG0193	aminoacyl-tRNA hydrolase activity
TPCCA_1012	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPCCA_1013	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPCCA_1015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPCCA_1016	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPCCA_1017	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPCCA_1018	COG1418	mRNA catabolic process
TPCCA_1019	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPCCA_1020	COG0154	amidase activity
TPCCA_1021	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPCCA_1022	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPCCA_1023	COG2137	regulation of response to DNA damage stimulus
TPCCA_1024	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TPCCA_1025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPCCA_1027	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TPCCA_1028	COG0210	DNA helicase
TPCCA_1029	COG0724	RNA recognition motif
TPCCA_1032	COG5341	Protein conserved in bacteria
TPCCA_1033	COG1752	Esterase of the alpha-beta hydrolase superfamily
TPCCA_1034	COG0530	calcium, potassium:sodium antiporter activity
TPCCA_1035	COG0525	valine-tRNA ligase activity
TPCCA_1037	COG1272	protein, Hemolysin III
TPCCA_1039	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TPCCA_1040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TPCCA_1041	COG0740	serine-type endopeptidase activity