locus-tag	class	description
HRI96_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRI96_00010	COG0187	DNA topoisomerase II activity
HRI96_00015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRI96_00055	COG0326	Molecular chaperone. Has ATPase activity
HRI96_00060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRI96_00080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRI96_00160	COG3549	Plasmid maintenance system killer
HRI96_00190	COG0673	inositol 2-dehydrogenase activity
HRI96_00210	COG1879	ABC-type sugar transport system periplasmic component
HRI96_00215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI96_00220	COG1129	ABC transporter
HRI96_00230	COG1070	Carbohydrate kinase
HRI96_00235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRI96_00245	COG2502	aspartate--ammonia ligase
HRI96_00250	COG0492	ferredoxin-NADP+ reductase activity
HRI96_00265	COG0765	amino acid transport
HRI96_00280	COG0697	spore germination
HRI96_00300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_00310	COG2972	Histidine kinase
HRI96_00325	COG1609	Transcriptional regulator
HRI96_00335	COG0205	6-phosphofructokinase activity
HRI96_00340	COG1674	ftsk spoiiie
HRI96_00350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRI96_00360	COG3264	Mechanosensitive ion channel
HRI96_00360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRI96_00365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI96_00370	COG1022	Amp-dependent synthetase and ligase
HRI96_00380	COG1053	succinate dehydrogenase
HRI96_00380	COG3976	FMN-binding domain protein
HRI96_00395	COG3048	D-serine ammonia-lyase activity
HRI96_00430	COG0840	transmembrane signaling receptor activity
HRI96_00455	COG2375	cellular response to nickel ion
HRI96_00455	COG1132	(ABC) transporter
HRI96_00470	COG1309	transcriptional regulator
HRI96_00485	COG1132	(ABC) transporter
HRI96_00490	COG1132	(ABC) transporter
HRI96_00505	COG0656	L-ascorbic acid biosynthetic process
HRI96_00520	COG0110	maltose O-acetyltransferase activity
HRI96_00560	COG2226	methyltransferase
HRI96_00580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRI96_00580	COG0604	alcohol dehydrogenase
HRI96_00580	COG3321	synthase
HRI96_00580	COG4221	oxidoreductase activity
HRI96_00585	COG0535	radical SAM domain protein
HRI96_00595	COG1733	regulation of RNA biosynthetic process
HRI96_00645	COG2197	response regulator
HRI96_00690	COG0583	DNA-binding transcription factor activity
HRI96_00715	COG0656	L-ascorbic acid biosynthetic process
HRI96_00720	COG2801	Transposase and inactivated derivatives
HRI96_00725	COG0583	DNA-binding transcription factor activity
HRI96_00830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HRI96_00855	COG2084	Dehydrogenase
HRI96_00860	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_00865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRI96_00875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_00875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_00885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRI96_00910	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_00925	COG1312	Catalyzes the dehydration of D-mannonate
HRI96_00940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRI96_00945	COG2801	Transposase and inactivated derivatives
HRI96_00970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRI96_00975	COG0488	(ABC) transporter
HRI96_00990	COG0281	malic enzyme
HRI96_01055	COG1733	regulation of RNA biosynthetic process
HRI96_01075	COG0442	prolyl-tRNA aminoacylation
HRI96_01105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HRI96_01115	COG1774	PSP1 C-terminal conserved region
HRI96_01130	COG0739	heme binding
HRI96_01135	COG0084	hydrolase, TatD family'
HRI96_01140	COG3116	cell division
HRI96_01140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRI96_01165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRI96_01170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRI96_01195	COG2183	response to ionizing radiation
HRI96_01210	COG1121	(ABC) transporter
HRI96_01220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRI96_01235	COG0395	ABC-type sugar transport system, permease component
HRI96_01245	COG2382	esterase
HRI96_01275	COG3507	Belongs to the glycosyl hydrolase 43 family
HRI96_01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRI96_01285	COG0641	radical SAM
HRI96_01290	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HRI96_01300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRI96_01305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRI96_01310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRI96_01325	COG1609	Transcriptional regulator
HRI96_01325	COG2207	Transcriptional regulator
HRI96_01330	COG1653	transport
HRI96_01335	COG1175	transmembrane transport
HRI96_01340	COG0395	ABC-type sugar transport system, permease component
HRI96_01345	COG3250	beta-galactosidase activity
HRI96_01360	COG0151	Belongs to the GarS family
HRI96_01370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRI96_01370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRI96_01380	COG1132	(ABC) transporter
HRI96_01385	COG1968	undecaprenyl-diphosphatase activity
HRI96_01395	COG1653	transport
HRI96_01400	COG0395	ABC-type sugar transport system, permease component
HRI96_01405	COG4209	transmembrane transport
HRI96_01410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRI96_01410	COG2207	Transcriptional regulator
HRI96_01460	COG0318	PFAM AMP-dependent synthetase and ligase
HRI96_01470	COG0167	dihydroorotate dehydrogenase activity
HRI96_01475	COG0116	Belongs to the methyltransferase superfamily
HRI96_01480	COG1309	transcriptional regulator
HRI96_01490	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRI96_01505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRI96_01530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_01535	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HRI96_01540	COG0501	Belongs to the peptidase M48B family
HRI96_01590	COG0579	oxidoreductase
HRI96_01610	COG1573	uracil-dna glycosylase
HRI96_01635	COG1063	alcohol dehydrogenase
HRI96_01640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_01650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_01650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_01655	COG0246	Mannitol dehydrogenase
HRI96_01660	COG2721	sulfolactate sulfo-lyase activity
HRI96_01680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRI96_01690	COG3041	Addiction module toxin RelE StbE family
HRI96_01710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRI96_01715	COG3012	SEC-C Motif Domain Protein
HRI96_01720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRI96_01725	COG0730	response to heat
HRI96_01730	COG1272	protein, Hemolysin III
HRI96_01740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRI96_01745	COG1477	protein flavinylation
HRI96_01750	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRI96_01755	COG2801	Transposase and inactivated derivatives
HRI96_01765	COG0166	Belongs to the GPI family
HRI96_01775	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HRI96_01790	COG1051	belongs to the nudix hydrolase family
HRI96_01800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRI96_01805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRI96_01810	COG0012	GTP binding
HRI96_01830	COG3858	chitin binding
HRI96_01835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRI96_01840	COG1522	sequence-specific DNA binding
HRI96_01845	COG0436	Aminotransferase
HRI96_01855	COG0357	Ribosomal RNA small subunit methyltransferase G
HRI96_01890	COG1127	ABC transporter
HRI96_01930	COG0714	Associated with various cellular activities
HRI96_01960	COG1193	negative regulation of DNA recombination
HRI96_01965	COG0484	heat shock protein binding
HRI96_01970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRI96_01985	COG0784	Response regulator, receiver
HRI96_01985	COG2205	protein histidine kinase activity
HRI96_01985	COG5002	protein histidine kinase activity
HRI96_01990	COG4565	transcriptional regulatory protein
HRI96_01995	COG0693	protein deglycase activity
HRI96_02000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HRI96_02005	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_02015	COG4166	transmembrane transport
HRI96_02025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRI96_02035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRI96_02040	COG0295	cytidine deaminase activity
HRI96_02055	COG1175	transmembrane transport
HRI96_02060	COG0395	ABC-type sugar transport system, permease component
HRI96_02070	COG0584	glycerophosphoryl diester phosphodiesterase
HRI96_02075	COG1609	Transcriptional regulator
HRI96_02085	COG0328	RNA-DNA hybrid ribonuclease activity
HRI96_02105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRI96_02110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRI96_02115	COG1733	regulation of RNA biosynthetic process
HRI96_02130	COG1773	rubredoxin
HRI96_02140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRI96_02145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRI96_02150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRI96_02160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRI96_02165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRI96_02170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRI96_02175	COG0762	integral membrane protein
HRI96_02180	COG0587	DNA-directed DNA polymerase activity
HRI96_02190	COG1053	succinate dehydrogenase
HRI96_02195	COG0516	GMP reductase activity
HRI96_02195	COG0517	IMP dehydrogenase activity
HRI96_02200	COG2755	lipolytic protein G-D-S-L family
HRI96_02205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRI96_02210	COG0800	Aldolase
HRI96_02215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRI96_02225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRI96_02230	COG0534	Mate efflux family protein
HRI96_02235	COG1121	(ABC) transporter
HRI96_02240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI96_02250	COG2885	chlorophyll binding
HRI96_02275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRI96_02285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI96_02315	COG0724	RNA recognition motif
HRI96_02320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRI96_02335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRI96_02340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRI96_02345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRI96_02350	COG0720	synthase
HRI96_02360	COG0107	imidazoleglycerol-phosphate synthase activity
HRI96_02365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRI96_02375	COG1373	ATPase (AAA superfamily
HRI96_02400	COG1321	iron dependent repressor
HRI96_02405	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRI96_02410	COG1121	(ABC) transporter
HRI96_02415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI96_02420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI96_02430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRI96_02440	COG2115	Belongs to the xylose isomerase family
HRI96_02445	COG1070	Carbohydrate kinase
HRI96_02455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRI96_02460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRI96_02465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRI96_02475	COG0534	Mate efflux family protein
HRI96_02480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRI96_02485	COG1126	abc transporter atp-binding protein
HRI96_02490	COG0765	amino acid transport
HRI96_02500	COG0564	pseudouridine synthase activity
HRI96_02505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRI96_02515	COG0504	CTP synthase activity
HRI96_02520	COG0017	Asparaginyl-tRNA synthetase
HRI96_02530	COG0154	amidase activity
HRI96_02560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRI96_02565	COG1469	GTP cyclohydrolase I activity
HRI96_02570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI96_02575	COG1846	Transcriptional regulator
HRI96_02600	COG0513	Belongs to the DEAD box helicase family
HRI96_02645	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRI96_02650	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRI96_02655	COG3845	ABC transporter
HRI96_02670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI96_02680	COG0563	adenylate kinase activity
HRI96_02710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRI96_02720	COG0484	heat shock protein binding
HRI96_02735	COG1366	Belongs to the anti-sigma-factor antagonist family
HRI96_02750	COG0495	leucyl-tRNA aminoacylation
HRI96_02790	COG1739	Uncharacterized protein family UPF0029
HRI96_02795	COG0656	L-ascorbic acid biosynthetic process
HRI96_02820	COG1882	Formate acetyltransferase
HRI96_02825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HRI96_02830	COG1609	Transcriptional regulator
HRI96_02835	COG1609	Transcriptional regulator
HRI96_02885	COG1175	transmembrane transport
HRI96_02890	COG0395	ABC-type sugar transport system, permease component
HRI96_02910	COG1349	DNA-binding transcription factor activity
HRI96_02935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI96_02950	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_02950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_02955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRI96_02985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRI96_02990	COG1120	ATPase activity
HRI96_02995	COG0556	nucleotide-excision repair
HRI96_03010	COG2003	Belongs to the UPF0758 family
HRI96_03020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRI96_03040	COG0215	cysteine-tRNA ligase activity
HRI96_03045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRI96_03050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRI96_03075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRI96_03080	COG0840	transmembrane signaling receptor activity
HRI96_03085	COG4452	Inner membrane protein CreD
HRI96_03095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRI96_03100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRI96_03105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRI96_03110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRI96_03120	COG0148	phosphopyruvate hydratase activity
HRI96_03130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRI96_03140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRI96_03165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRI96_03170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRI96_03190	COG2089	acid synthase
HRI96_03195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRI96_03200	COG4310	Domain of unknown function (DUF2172)
HRI96_03215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRI96_03225	COG1454	alcohol dehydrogenase
HRI96_03235	COG1215	transferase activity, transferring glycosyl groups
HRI96_03265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRI96_03270	COG1215	transferase activity, transferring glycosyl groups
HRI96_03295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRI96_03310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRI96_03350	COG0840	transmembrane signaling receptor activity
HRI96_03370	COG2801	Transposase and inactivated derivatives
HRI96_03380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRI96_03405	COG0708	Exodeoxyribonuclease III
HRI96_03410	COG1747	RNA polymerase binding
HRI96_03410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRI96_03420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRI96_03440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRI96_03450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRI96_03455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRI96_03465	COG0539	negative regulation of cytoplasmic translation
HRI96_03495	COG0363	glucosamine-6-phosphate deaminase activity
HRI96_03500	COG1609	Transcriptional regulator
HRI96_03515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_03520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRI96_03525	COG0126	phosphoglycerate kinase activity
HRI96_03530	COG0149	triose-phosphate isomerase activity
HRI96_03535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRI96_03555	COG1269	ATP hydrolysis coupled proton transport
HRI96_03575	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HRI96_03580	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HRI96_03585	COG1394	ATPase activity, coupled to movement of substances
HRI96_03595	COG0484	heat shock protein binding
HRI96_03600	COG0024	Methionine aminopeptidase
HRI96_03605	COG0372	Belongs to the citrate synthase family
HRI96_03610	COG1187	pseudouridine synthase activity
HRI96_03615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRI96_03625	COG1509	lysine 2,3-aminomutase activity
HRI96_03645	COG4115	mRNA cleavage
HRI96_03650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRI96_03675	COG1840	ABC-type Fe3 transport system, periplasmic component
HRI96_03680	COG3842	ATPase activity
HRI96_03730	COG0525	valine-tRNA ligase activity
HRI96_03745	COG2233	PERMEase
HRI96_03785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRI96_03805	COG1196	nuclear chromosome segregation
HRI96_03820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRI96_03830	COG0475	glutathione-regulated potassium exporter activity
HRI96_03875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRI96_03880	COG0436	Aminotransferase
HRI96_03890	COG2198	Histidine kinase
HRI96_03890	COG0643	Histidine kinase
HRI96_03895	COG0835	chemotaxis
HRI96_03905	COG2201	protein-glutamate methylesterase activity
HRI96_03915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRI96_03920	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRI96_03925	COG0037	tRNA processing
HRI96_03930	COG4221	oxidoreductase activity
HRI96_03935	COG0426	domain, Protein
HRI96_03935	COG1773	rubredoxin
HRI96_03950	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRI96_03950	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRI96_03950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRI96_03950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRI96_03975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRI96_03975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HRI96_03980	COG3437	response regulator, receiver
HRI96_03980	COG0784	Response regulator, receiver
HRI96_03985	COG1671	Belongs to the UPF0178 family
HRI96_03990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HRI96_04005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRI96_04050	COG0129	dihydroxy-acid dehydratase activity
HRI96_04055	COG0028	Belongs to the TPP enzyme family
HRI96_04075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRI96_04080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRI96_04085	COG0765	amino acid transport
HRI96_04135	COG1837	Belongs to the UPF0109 family
HRI96_04140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRI96_04145	COG0336	Belongs to the RNA methyltransferase TrmD family
HRI96_04150	COG0335	large ribosomal subunit rRNA binding
HRI96_04160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRI96_04205	COG0018	arginyl-trna synthetase
HRI96_04225	COG0601	transmembrane transport
HRI96_04230	COG0444	Belongs to the ABC transporter superfamily
HRI96_04235	COG4608	Belongs to the ABC transporter superfamily
HRI96_04255	COG1773	rubredoxin
HRI96_04255	COG1592	Rubrerythrin
HRI96_04270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRI96_04275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI96_04280	COG1979	alcohol dehydrogenase
HRI96_04285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRI96_04315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRI96_04330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRI96_04335	COG0037	tRNA processing
HRI96_04345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI96_04350	COG0481	GTPase activity
HRI96_04355	COG2604	Protein of unknown function DUF115
HRI96_04375	COG0124	histidyl-tRNA synthetase
HRI96_04380	COG2089	acid synthase
HRI96_04385	COG1528	Iron-storage protein
HRI96_04390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HRI96_04400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRI96_04425	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HRI96_04445	COG1840	ABC-type Fe3 transport system, periplasmic component
HRI96_04450	COG4753	response regulator
HRI96_04450	COG2207	Transcriptional regulator
HRI96_04455	COG2972	Histidine kinase
HRI96_04475	COG1285	pathogenesis
HRI96_04510	COG3708	Transcriptional regulator
HRI96_04510	COG2207	Transcriptional regulator
HRI96_04520	COG0500	methyltransferase
HRI96_04535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRI96_04575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRI96_04585	COG2373	Large extracellular alpha-helical protein
HRI96_04590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRI96_04595	COG1070	Carbohydrate kinase
HRI96_04605	COG0733	neurotransmitter:sodium symporter activity
HRI96_04640	COG2226	methyltransferase
HRI96_04645	COG0588	phosphoglycerate mutase activity
HRI96_04665	COG0557	exoribonuclease II activity
HRI96_04685	COG0542	response to heat
HRI96_04700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRI96_04710	COG0419	ATPase involved in DNA repair
HRI96_04715	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRI96_04725	COG1309	transcriptional regulator
HRI96_04735	COG1132	(ABC) transporter
HRI96_04740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRI96_04750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRI96_04795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRI96_04805	COG0534	Mate efflux family protein
HRI96_04810	COG1012	belongs to the aldehyde dehydrogenase family
HRI96_04815	COG1349	DNA-binding transcription factor activity
HRI96_04820	COG0191	fructose-bisphosphate aldolase activity
HRI96_04825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI96_04835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_04840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_04845	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_04850	COG1063	alcohol dehydrogenase
HRI96_04860	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRI96_04865	COG0579	oxidoreductase
HRI96_04870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_04870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_04880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_04890	COG0537	adenosine 5'-monophosphoramidase activity
HRI96_04900	COG0719	Fe-S assembly protein
HRI96_04910	COG0396	ATPase activity
HRI96_04915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRI96_04920	COG0436	Aminotransferase
HRI96_04925	COG4806	L-rhamnose isomerase
HRI96_04940	COG3842	ATPase activity
HRI96_04945	COG4149	molybdate abc transporter
HRI96_04955	COG3290	protein histidine kinase activity
HRI96_04960	COG4565	transcriptional regulatory protein
HRI96_04970	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HRI96_04975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRI96_04980	COG0740	serine-type endopeptidase activity
HRI96_04985	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRI96_05025	COG3875	lactate racemase activity
HRI96_05035	COG0492	ferredoxin-NADP+ reductase activity
HRI96_05040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_05050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI96_05050	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_05055	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_05065	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_05070	COG4977	sequence-specific DNA binding
HRI96_05085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRI96_05090	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HRI96_05100	COG1214	PFAM Peptidase M22, glycoprotease
HRI96_05105	COG0802	atpase or kinase
HRI96_05145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRI96_05175	COG4821	SIS domain
HRI96_05195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRI96_05220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRI96_05240	COG3549	Plasmid maintenance system killer
HRI96_05265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRI96_05270	COG1122	ATPase activity
HRI96_05275	COG1268	BioY protein
HRI96_05280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRI96_05285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRI96_05290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRI96_05305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRI96_05320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRI96_05325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRI96_05335	COG0739	heme binding
HRI96_05340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRI96_05340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRI96_05345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRI96_05365	COG3620	sequence-specific DNA binding
HRI96_05375	COG3421	Type III restriction
HRI96_05385	COG3976	FMN-binding domain protein
HRI96_05385	COG1053	succinate dehydrogenase
HRI96_05395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRI96_05400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRI96_05405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRI96_05410	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HRI96_05420	COG0736	holo-[acyl-carrier-protein] synthase activity
HRI96_05430	COG0101	tRNA pseudouridine synthase activity
HRI96_05435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRI96_05440	COG1573	uracil-dna glycosylase
HRI96_05445	COG0438	transferase activity, transferring glycosyl groups
HRI96_05465	COG0301	tRNA thio-modification
HRI96_05475	COG1022	Amp-dependent synthetase and ligase
HRI96_05560	COG0515	serine threonine protein kinase
HRI96_05560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRI96_05590	COG3549	Plasmid maintenance system killer
HRI96_05600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRI96_05610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRI96_05650	COG0009	L-threonylcarbamoyladenylate synthase
HRI96_05660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRI96_05670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRI96_05675	COG5002	protein histidine kinase activity
HRI96_05680	COG0745	RESPONSE REGULATOR receiver
HRI96_05695	COG1360	Flagellar Motor Protein
HRI96_05700	COG1580	Controls the rotational direction of flagella during chemotaxis
HRI96_05705	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRI96_05720	COG1338	Plays a role in the flagellum-specific transport system
HRI96_05725	COG1987	bacterial-type flagellum assembly
HRI96_05730	COG1684	flagellar biosynthetic protein fliR
HRI96_05735	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRI96_05740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRI96_05760	COG1191	sigma factor activity
HRI96_05785	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HRI96_05795	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HRI96_05800	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HRI96_05805	COG1394	ATPase activity, coupled to movement of substances
HRI96_05810	COG1269	ATP hydrolysis coupled proton transport
HRI96_05820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRI96_05825	COG3118	belongs to the thioredoxin family
HRI96_05860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRI96_05865	COG0706	membrane insertase activity
HRI96_05890	COG0463	Glycosyl transferase, family 2
HRI96_05930	COG0426	domain, Protein
HRI96_05935	COG1102	Psort location Cytoplasmic, score
HRI96_05945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRI96_05975	COG0360	Binds together with S18 to 16S ribosomal RNA
HRI96_05980	COG0629	single-stranded DNA binding
HRI96_05985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRI96_05995	COG0305	Participates in initiation and elongation during chromosome replication
HRI96_06010	COG3386	PFAM SMP-30 Gluconolaconase
HRI96_06020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRI96_06030	COG0617	tRNA 3'-terminal CCA addition
HRI96_06040	COG0564	pseudouridine synthase activity
HRI96_06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRI96_06105	COG1486	melibiose metabolic process
HRI96_06110	COG0395	ABC-type sugar transport system, permease component
HRI96_06115	COG1175	transmembrane transport
HRI96_06120	COG1653	transport
HRI96_06125	COG2972	Histidine kinase
HRI96_06130	COG4753	response regulator
HRI96_06130	COG2207	Transcriptional regulator
HRI96_06140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI96_06145	COG3842	ATPase activity
HRI96_06150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRI96_06155	COG0460	homoserine dehydrogenase
HRI96_06155	COG0527	aspartate kinase activity
HRI96_06160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRI96_06165	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_06175	COG1175	transmembrane transport
HRI96_06180	COG0395	ABC-type sugar transport system, permease component
HRI96_06185	COG1151	hydroxylamine reductase activity
HRI96_06195	COG1136	(ABC) transporter
HRI96_06235	COG0564	pseudouridine synthase activity
HRI96_06240	COG0564	pseudouridine synthase activity
HRI96_06250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRI96_06255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRI96_06285	COG1234	tRNA 3'-trailer cleavage
HRI96_06305	COG0571	ribonuclease III activity
HRI96_06315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRI96_06320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRI96_06330	COG1413	lyase activity
HRI96_06340	COG0424	maF-like protein
HRI96_06345	COG0052	Belongs to the universal ribosomal protein uS2 family
HRI96_06350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRI96_06355	COG0233	cytoplasmic translational termination
HRI96_06360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRI96_06365	COG0575	Belongs to the CDS family
HRI96_06370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRI96_06375	COG0750	zinc metalloprotease
HRI96_06385	COG0297	glycogen (starch) synthase activity
HRI96_06405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRI96_06410	COG0217	transcriptional regulatory protein
HRI96_06415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI96_06420	COG1482	cell wall glycoprotein biosynthetic process
HRI96_06430	COG0813	purine-nucleoside phosphorylase activity
HRI96_06465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRI96_06475	COG0772	Belongs to the SEDS family
HRI96_06480	COG0768	penicillin binding
HRI96_06495	COG1077	Cell shape determining protein MreB Mrl
HRI96_06515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRI96_06520	COG0358	DNA primase activity
HRI96_06525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRI96_06565	COG0617	tRNA 3'-terminal CCA addition
HRI96_06570	COG0180	Tryptophanyl-tRNA synthetase
HRI96_06575	COG0285	dihydrofolate synthase activity
HRI96_06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRI96_06590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRI96_06600	COG4608	Belongs to the ABC transporter superfamily
HRI96_06605	COG0444	Belongs to the ABC transporter superfamily
HRI96_06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRI96_06620	COG0747	negative chemotaxis
HRI96_06650	COG2348	transferase activity, transferring amino-acyl groups
HRI96_06665	COG3706	GGDEF domain
HRI96_06685	COG1074	ATP-dependent DNA helicase activity
HRI96_06705	COG4786	Flagellar basal body rod
HRI96_06710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRI96_06715	COG2204	response regulator
HRI96_06720	COG3852	Histidine kinase
HRI96_06735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRI96_06755	COG3976	FMN-binding domain protein
HRI96_06755	COG0431	NADPH-dependent FMN reductase
HRI96_06755	COG1053	succinate dehydrogenase
HRI96_06760	COG1053	succinate dehydrogenase
HRI96_06760	COG3976	FMN-binding domain protein
HRI96_06765	COG0730	response to heat
HRI96_06790	COG2169	Transcriptional regulator
HRI96_06800	COG2211	Major facilitator Superfamily
HRI96_06850	COG3330	Domain of unknown function (DUF4912)
HRI96_06860	COG4214	carbohydrate transport
HRI96_06870	COG4213	ABC transporter substrate-binding protein
HRI96_06890	COG1312	Catalyzes the dehydration of D-mannonate
HRI96_06895	COG0473	3-isopropylmalate dehydrogenase activity
HRI96_06895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRI96_06900	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_06905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_06915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_06920	COG1904	glucuronate isomerase
HRI96_06950	COG1388	LysM domain
HRI96_06950	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRI96_06960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRI96_06970	COG0731	radical SAM domain protein
HRI96_06975	COG1570	exodeoxyribonuclease VII activity
HRI96_06980	COG1722	exodeoxyribonuclease VII activity
HRI96_06985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRI96_06990	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HRI96_07000	COG3833	ABC-type maltose transport systems, permease component
HRI96_07005	COG1175	transmembrane transport
HRI96_07015	COG2207	Transcriptional regulator
HRI96_07020	COG2972	Histidine kinase
HRI96_07045	COG1366	Belongs to the anti-sigma-factor antagonist family
HRI96_07055	COG1802	Transcriptional regulator
HRI96_07070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI96_07075	COG1129	ABC transporter
HRI96_07105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRI96_07125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRI96_07130	COG2255	four-way junction helicase activity
HRI96_07135	COG0632	four-way junction helicase activity
HRI96_07145	COG1136	(ABC) transporter
HRI96_07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRI96_07180	COG1234	tRNA 3'-trailer cleavage
HRI96_07210	COG2801	Transposase and inactivated derivatives
HRI96_07215	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRI96_07235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRI96_07285	COG0626	cystathionine gamma-synthase activity
HRI96_07315	COG1373	ATPase (AAA superfamily
HRI96_07325	COG1966	Carbon starvation protein
HRI96_07340	COG0006	proline dipeptidase activity
HRI96_07345	COG0670	Belongs to the BI1 family
HRI96_07350	COG1904	glucuronate isomerase
HRI96_07360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRI96_07370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRI96_07375	COG3977	Valine--pyruvate aminotransferase
HRI96_07385	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HRI96_07400	COG1136	(ABC) transporter
HRI96_07405	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRI96_07415	COG0552	protein localization to endoplasmic reticulum
HRI96_07450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRI96_07455	COG1480	7TM receptor with intracellular HD hydrolase
HRI96_07460	COG1702	phosphate starvation-inducible protein PhoH
HRI96_07470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRI96_07490	COG2084	Dehydrogenase
HRI96_07495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRI96_07505	COG1157	protein secretion by the type III secretion system
HRI96_07510	COG1317	bacterial-type flagellum organization
HRI96_07520	COG1766	The M ring may be actively involved in energy transduction
HRI96_07525	COG0583	DNA-binding transcription factor activity
HRI96_07535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRI96_07535	COG0248	Ppx GppA phosphatase
HRI96_07570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRI96_07575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRI96_07580	COG4974	Belongs to the 'phage' integrase family
HRI96_07585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRI96_07585	COG0551	DNA topoisomerase type I activity
HRI96_07590	COG0758	DNA mediated transformation
HRI96_07590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRI96_07625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRI96_07635	COG0275	rRNA processing
HRI96_07640	COG2001	Belongs to the MraZ family
HRI96_07665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI96_07670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRI96_07685	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRI96_07690	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRI96_07695	COG3845	ABC transporter
HRI96_07700	COG1744	ABC transporter substrate-binding protein PnrA-like
HRI96_07710	COG0497	DNA recombination
HRI96_07715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRI96_07725	COG0835	chemotaxis
HRI96_07730	COG1040	competence protein
HRI96_07735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRI96_07745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRI96_07755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRI96_07765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRI96_07770	COG1104	cysteine desulfurase activity
HRI96_07795	COG0210	DNA helicase
HRI96_07800	COG0488	(ABC) transporter
HRI96_07805	COG0513	Belongs to the DEAD box helicase family
HRI96_07825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRI96_07835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRI96_07845	COG0268	Binds directly to 16S ribosomal RNA
HRI96_07860	COG1199	ATP-dependent helicase activity
HRI96_07865	COG0800	Aldolase
HRI96_07880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI96_07905	COG0280	phosphate acetyltransferase
HRI96_07925	COG0343	queuine tRNA-ribosyltransferase activity
HRI96_07940	COG0756	dUTP diphosphatase activity
HRI96_07945	COG1185	polyribonucleotide nucleotidyltransferase activity
HRI96_07950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRI96_07955	COG0196	riboflavin kinase activity
HRI96_07960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRI96_07965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRI96_07970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRI96_07980	COG0779	Required for maturation of 30S ribosomal subunits
HRI96_07985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRI96_07990	COG0668	transmembrane transport
HRI96_08040	COG0564	pseudouridine synthase activity
HRI96_08050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRI96_08050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI96_08050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI96_08060	COG1464	Belongs to the NlpA lipoprotein family
HRI96_08070	COG0494	nUDIX hydrolase
HRI96_08090	COG0653	protein targeting
HRI96_08095	COG0681	Belongs to the peptidase S26 family
HRI96_08115	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRI96_08120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRI96_08135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRI96_08160	COG3842	ATPase activity
HRI96_08210	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI96_08220	COG1129	ABC transporter
HRI96_08225	COG1879	ABC-type sugar transport system periplasmic component
HRI96_08240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI96_08250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI96_08255	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_08260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRI96_08270	COG3263	regulation of cellular component size
HRI96_08275	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HRI96_08300	COG0473	3-isopropylmalate dehydrogenase activity
HRI96_08305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRI96_08345	COG1373	ATPase (AAA superfamily
HRI96_08385	COG0492	ferredoxin-NADP+ reductase activity
HRI96_08390	COG0450	alkyl hydroperoxide reductase
HRI96_08395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRI96_08400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRI96_08420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRI96_08420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRI96_08420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRI96_08425	COG0237	dephospho-CoA kinase activity
HRI96_08445	COG1744	ABC transporter substrate-binding protein PnrA-like
HRI96_08450	COG3845	ABC transporter
HRI96_08465	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HRI96_08480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRI96_08495	COG1937	Protein conserved in bacteria
HRI96_08500	COG2217	Heavy metal translocating P-type atpase
HRI96_08515	COG0601	transmembrane transport
HRI96_08530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRI96_08550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HRI96_08555	COG1162	GTPase activity
HRI96_08560	COG1193	negative regulation of DNA recombination
HRI96_08565	COG1438	arginine binding
HRI96_08570	COG0084	hydrolase, TatD family'
HRI96_08585	COG0191	fructose-bisphosphate aldolase activity
HRI96_08590	COG2252	PERMEase
HRI96_08595	COG1686	Belongs to the peptidase S11 family
HRI96_08610	COG0739	heme binding
HRI96_08615	COG0681	Belongs to the peptidase S26 family
HRI96_08620	COG0768	penicillin binding
HRI96_08640	COG0423	glycine-tRNA ligase activity
HRI96_08645	COG1122	ATPase activity
HRI96_08650	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRI96_08670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRI96_08675	COG2816	NAD+ diphosphatase activity
HRI96_08680	COG0137	argininosuccinate synthase activity
HRI96_08685	COG0523	cobalamin synthesis protein
HRI96_08695	COG2801	Transposase and inactivated derivatives
HRI96_08700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRI96_08705	COG0330	HflC and HflK could
HRI96_08710	COG0330	HflC and HflK could
HRI96_08720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRI96_08725	COG1929	Belongs to the glycerate kinase type-1 family
HRI96_08750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRI96_08765	COG0826	peptidase U32
HRI96_08800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRI96_08805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRI96_08810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRI96_08815	COG1063	alcohol dehydrogenase
HRI96_08820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRI96_08825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRI96_08830	COG1862	Preprotein translocase
HRI96_08835	COG2203	Gaf domain
HRI96_08835	COG4251	negative regulation of phosphorylation
HRI96_08835	COG5001	Diguanylate cyclase
HRI96_08835	COG3706	GGDEF domain
HRI96_08840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRI96_08870	COG1397	ADP-ribosylglycohydrolase
HRI96_08900	COG4656	Part of a membrane complex involved in electron transport
HRI96_08905	COG4658	electron transport chain
HRI96_08915	COG4660	Part of a membrane complex involved in electron transport
HRI96_08920	COG4657	Part of a membrane complex involved in electron transport
HRI96_08925	COG2878	Part of a membrane complex involved in electron transport
HRI96_08965	COG2011	ABC-type metal ion transport system permease component
HRI96_08970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRI96_08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRI96_09010	COG1595	DNA-templated transcription, initiation
HRI96_09020	COG0739	heme binding
HRI96_09025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRI96_09045	COG2201	protein-glutamate methylesterase activity
HRI96_09055	COG0504	CTP synthase activity
HRI96_09070	COG1137	ATPase activity
HRI96_09075	COG1418	mRNA catabolic process
HRI96_09100	COG0800	Aldolase
HRI96_09105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRI96_09125	COG0616	signal peptide processing
HRI96_09145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRI96_09155	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRI96_09165	COG3842	ATPase activity
HRI96_09170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRI96_09175	COG1177	transmembrane transport
HRI96_09190	COG2885	chlorophyll binding
HRI96_09200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRI96_09200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRI96_09225	COG0848	biopolymer transport protein
HRI96_09230	COG0811	peptide transport
HRI96_09270	COG0728	peptidoglycan biosynthetic process
HRI96_09275	COG0006	proline dipeptidase activity
HRI96_09290	COG0322	excinuclease ABC activity
HRI96_09295	COG1349	DNA-binding transcription factor activity
HRI96_09300	COG4948	Mandelate Racemase Muconate Lactonizing
HRI96_09305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRI96_09310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRI96_09325	COG2342	PFAM TM1410 hypothetical-related protein
HRI96_09330	COG2703	oxygen carrier activity
HRI96_09335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRI96_09345	COG1959	2 iron, 2 sulfur cluster binding
HRI96_09355	COG1131	(ABC) transporter
HRI96_09375	COG0640	Transcriptional regulator
HRI96_09380	COG2217	Heavy metal translocating P-type atpase
HRI96_09385	COG0193	aminoacyl-tRNA hydrolase activity
HRI96_09390	COG3956	TIGRFAM MazG family protein
HRI96_09405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRI96_09425	COG1205	dead DEAH box helicase
HRI96_09425	COG1111	helicase
HRI96_09450	COG0740	serine-type endopeptidase activity
HRI96_09460	COG0724	RNA recognition motif
HRI96_09465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRI96_09480	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRI96_09495	COG1175	transmembrane transport
HRI96_09510	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRI96_09515	COG0501	Belongs to the peptidase M48B family
HRI96_09535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRI96_09585	COG0783	Belongs to the Dps family
HRI96_09590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRI96_09595	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HRI96_09605	COG4667	esterase of the alpha-beta hydrolase superfamily
HRI96_09630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRI96_09640	COG0494	nUDIX hydrolase
HRI96_09645	COG1652	LysM domain
HRI96_09655	COG4443	Transcriptional Coactivator p15 (PC4)
HRI96_09670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI96_09715	COG0613	PHP domain protein
HRI96_09720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRI96_09720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRI96_09735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRI96_09740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRI96_09745	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_09750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRI96_09765	COG1454	alcohol dehydrogenase
HRI96_09765	COG1012	belongs to the aldehyde dehydrogenase family
HRI96_09775	COG2873	o-acetylhomoserine
HRI96_09790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRI96_09805	COG0488	(ABC) transporter
HRI96_09810	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HRI96_09815	COG3958	Transketolase
HRI96_09820	COG3959	Transketolase, thiamine diphosphate binding domain
HRI96_09830	COG2186	Transcriptional regulator
HRI96_09835	COG0534	Mate efflux family protein
HRI96_09845	COG0659	secondary active sulfate transmembrane transporter activity
HRI96_09850	COG1126	abc transporter atp-binding protein
HRI96_09855	COG0765	amino acid transport
HRI96_09860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRI96_09885	COG0058	SHG alpha-glucan phosphorylase activity
HRI96_09895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRI96_09905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRI96_09930	COG1028	Short-chain dehydrogenase reductase Sdr
HRI96_09935	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRI96_09955	COG0793	Belongs to the peptidase S41A family
HRI96_09960	COG0455	bacterial-type flagellum organization
HRI96_09965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRI96_09970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRI96_09980	COG0517	IMP dehydrogenase activity
HRI96_10000	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRI96_10015	COG0203	ribosomal protein L17
HRI96_10020	COG0202	RNA polymerase activity
HRI96_10025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRI96_10035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRI96_10045	COG0200	Binds to the 23S rRNA
HRI96_10050	COG1841	ribosomal large subunit assembly
HRI96_10055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRI96_10065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRI96_10070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRI96_10075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRI96_10080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRI96_10090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRI96_10095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRI96_10100	COG0255	Belongs to the universal ribosomal protein uL29 family
HRI96_10110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRI96_10115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRI96_10120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRI96_10125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRI96_10130	COG0089	rRNA binding
HRI96_10135	COG0088	Forms part of the polypeptide exit tunnel
HRI96_10140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRI96_10145	COG0051	transcription antitermination factor activity, RNA binding
HRI96_10150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRI96_10155	COG0049	tRNA binding
HRI96_10160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRI96_10170	COG0085	RNA polymerase activity
HRI96_10180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRI96_10185	COG0081	regulation of translation
HRI96_10190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRI96_10195	COG0250	Participates in transcription elongation, termination and antitermination
HRI96_10200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRI96_10210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRI96_10235	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRI96_10240	COG1216	Glycosyl transferase, family 2
HRI96_10245	COG1045	serine acetyltransferase
HRI96_10255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRI96_10280	COG0248	Ppx GppA phosphatase
HRI96_10285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRI96_10290	COG0840	transmembrane signaling receptor activity
HRI96_10300	COG0205	6-phosphofructokinase activity
HRI96_10330	COG3340	Belongs to the peptidase S51 family
HRI96_10340	COG0039	L-malate dehydrogenase activity
HRI96_10365	COG0789	Transcriptional regulator
HRI96_10370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRI96_10375	COG3804	dihydrodipicolinate reductase
HRI96_10380	COG0840	transmembrane signaling receptor activity
HRI96_10390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRI96_10405	COG1078	dGTPase activity
HRI96_10430	COG0246	Mannitol dehydrogenase
HRI96_10435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRI96_10495	COG3041	Addiction module toxin RelE StbE family
HRI96_10510	COG1116	anion transmembrane transporter activity
HRI96_10515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRI96_10535	COG2375	cellular response to nickel ion
HRI96_10535	COG1132	(ABC) transporter
HRI96_10540	COG1132	(ABC) transporter
HRI96_10565	COG1120	ATPase activity
HRI96_10570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRI96_10575	COG2315	Protein conserved in bacteria
HRI96_10600	COG2337	Toxic component of a toxin-antitoxin (TA) module
HRI96_10610	COG4115	mRNA cleavage
HRI96_10615	COG3842	ATPase activity
HRI96_10620	COG1177	transmembrane transport
HRI96_10635	COG0371	Dehydrogenase
HRI96_10645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI96_10650	COG1970	mechanosensitive ion channel activity
HRI96_10655	COG1368	sulfuric ester hydrolase activity
HRI96_10705	COG1902	pentaerythritol trinitrate reductase activity
HRI96_10715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRI96_10720	COG4213	ABC transporter substrate-binding protein
HRI96_10725	COG1129	ABC transporter
HRI96_10730	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI96_10735	COG0205	6-phosphofructokinase activity
HRI96_10740	COG0191	fructose-bisphosphate aldolase activity
HRI96_10750	COG2188	Transcriptional regulator
HRI96_10755	COG2188	Transcriptional regulator
HRI96_10760	COG3119	arylsulfatase activity
HRI96_10780	COG0673	inositol 2-dehydrogenase activity
HRI96_10810	COG1940	carbohydrate kinase activity
HRI96_10815	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRI96_10815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRI96_10815	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRI96_10815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRI96_10820	COG0445	tRNA wobble uridine modification
HRI96_10825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRI96_10830	COG2890	protein-(glutamine-N5) methyltransferase activity
HRI96_10835	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRI96_10840	COG0657	acetylesterase activity
HRI96_10845	COG0826	peptidase U32
HRI96_10875	COG1640	4-alpha-glucanotransferase
HRI96_10880	COG0131	Imidazoleglycerol-phosphate dehydratase
HRI96_10885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRI96_10900	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRI96_10910	COG0071	Belongs to the small heat shock protein (HSP20) family
HRI96_10920	COG0564	pseudouridine synthase activity
HRI96_10950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRI96_10955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRI96_10960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRI96_10970	COG3300	MHYT domain
HRI96_10970	COG5001	Diguanylate cyclase
HRI96_10975	COG0534	Mate efflux family protein
HRI96_10980	COG2848	UPF0210 protein
HRI96_10985	COG0038	chloride channel
HRI96_10990	COG1119	ATPase activity
HRI96_11000	COG3885	ferrous iron binding
HRI96_11000	COG2078	PFAM AMMECR1 domain protein
HRI96_11025	COG2801	Transposase and inactivated derivatives
HRI96_11060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRI96_11075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRI96_11080	COG1047	Peptidyl-prolyl cis-trans
HRI96_11100	COG1917	Cupin 2, conserved barrel domain protein
HRI96_11105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRI96_11110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRI96_11110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRI96_11125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRI96_11130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRI96_11140	COG0622	Phosphoesterase
HRI96_11145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRI96_11150	COG0574	Belongs to the PEP-utilizing enzyme family
HRI96_11150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRI96_11170	COG0583	DNA-binding transcription factor activity
HRI96_11180	COG0395	ABC-type sugar transport system, permease component
HRI96_11210	COG0534	Mate efflux family protein
HRI96_11215	COG3118	belongs to the thioredoxin family
HRI96_11230	COG0492	ferredoxin-NADP+ reductase activity
HRI96_11235	COG2801	Transposase and inactivated derivatives
HRI96_11245	COG1757	Na H antiporter
HRI96_11260	COG1846	Transcriptional regulator
HRI96_11270	COG0138	bifunctional purine biosynthesis protein purh
HRI96_11285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRI96_11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRI96_11295	COG0488	(ABC) transporter
HRI96_11315	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HRI96_11325	COG1704	LemA family
HRI96_11350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRI96_11355	COG3830	Belongs to the UPF0237 family
HRI96_11365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRI96_11370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRI96_11375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HRI96_11390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRI96_11390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRI96_11390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI96_11405	COG1640	4-alpha-glucanotransferase
HRI96_11415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRI96_11440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRI96_11445	COG0242	peptide deformylase activity
HRI96_11450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRI96_11455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRI96_11455	COG0140	phosphoribosyl-ATP diphosphatase activity
HRI96_11470	COG3842	ATPase activity
HRI96_11475	COG1840	ABC-type Fe3 transport system, periplasmic component
HRI96_11480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRI96_11490	COG4536	flavin adenine dinucleotide binding
HRI96_11495	COG4536	flavin adenine dinucleotide binding
HRI96_11510	COG0564	pseudouridine synthase activity
HRI96_11515	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRI96_11535	COG1639	'signal transduction protein
HRI96_11540	COG0656	L-ascorbic acid biosynthetic process
HRI96_11620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRI96_11630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRI96_11635	COG1475	DNA binding
HRI96_11640	COG1192	Involved in chromosome partitioning
HRI96_11650	COG0561	phosphatase activity
HRI96_11665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRI96_11680	COG1847	R3H domain protein
HRI96_11685	COG0706	membrane insertase activity
HRI96_11690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRI96_11695	COG0594	ribonuclease P activity
HRI96_11700	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRI96_11705	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HRI96_11710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRI96_11715	COG0592	DNA-directed DNA polymerase activity