locus-tag	class	description
HXT04_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HXT04_00010	COG0592	DNA-directed DNA polymerase activity
HXT04_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HXT04_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HXT04_00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HXT04_00035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HXT04_00040	COG0706	membrane insertase activity
HXT04_00045	COG1847	R3H domain protein
HXT04_00055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXT04_00070	COG0561	phosphatase activity
HXT04_00080	COG1192	Involved in chromosome partitioning
HXT04_00085	COG1475	DNA binding
HXT04_00090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HXT04_00105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HXT04_00195	COG0656	L-ascorbic acid biosynthetic process
HXT04_00200	COG1639	'signal transduction protein
HXT04_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXT04_00225	COG0564	pseudouridine synthase activity
HXT04_00240	COG4536	flavin adenine dinucleotide binding
HXT04_00245	COG4536	flavin adenine dinucleotide binding
HXT04_00270	COG1840	ABC-type Fe3 transport system, periplasmic component
HXT04_00275	COG3842	ATPase activity
HXT04_00290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HXT04_00290	COG0140	phosphoribosyl-ATP diphosphatase activity
HXT04_00295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXT04_00300	COG0242	peptide deformylase activity
HXT04_00305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXT04_00325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HXT04_00335	COG1640	4-alpha-glucanotransferase
HXT04_00350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXT04_00350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXT04_00350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXT04_00365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HXT04_00370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HXT04_00375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXT04_00385	COG3830	Belongs to the UPF0237 family
HXT04_00390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HXT04_00415	COG1704	LemA family
HXT04_00425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HXT04_00445	COG0488	(ABC) transporter
HXT04_00450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXT04_00455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXT04_00470	COG0138	bifunctional purine biosynthesis protein purh
HXT04_00480	COG1846	Transcriptional regulator
HXT04_00495	COG1757	Na H antiporter
HXT04_00505	COG0492	ferredoxin-NADP+ reductase activity
HXT04_00520	COG3118	belongs to the thioredoxin family
HXT04_00525	COG0534	Mate efflux family protein
HXT04_00540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HXT04_00555	COG0395	ABC-type sugar transport system, permease component
HXT04_00565	COG0583	DNA-binding transcription factor activity
HXT04_00585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXT04_00585	COG0574	Belongs to the PEP-utilizing enzyme family
HXT04_00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXT04_00595	COG0622	Phosphoesterase
HXT04_00605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXT04_00610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HXT04_00625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HXT04_00625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HXT04_00630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXT04_00635	COG1917	Cupin 2, conserved barrel domain protein
HXT04_00655	COG1047	Peptidyl-prolyl cis-trans
HXT04_00660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HXT04_00675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXT04_00730	COG2078	PFAM AMMECR1 domain protein
HXT04_00730	COG3885	ferrous iron binding
HXT04_00740	COG1119	ATPase activity
HXT04_00745	COG0038	chloride channel
HXT04_00750	COG2848	UPF0210 protein
HXT04_00755	COG0534	Mate efflux family protein
HXT04_00760	COG5001	Diguanylate cyclase
HXT04_00760	COG3300	MHYT domain
HXT04_00770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXT04_00775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HXT04_00780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HXT04_00810	COG0564	pseudouridine synthase activity
HXT04_00820	COG0071	Belongs to the small heat shock protein (HSP20) family
HXT04_00830	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HXT04_00845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HXT04_00850	COG0131	Imidazoleglycerol-phosphate dehydratase
HXT04_00855	COG1640	4-alpha-glucanotransferase
HXT04_00885	COG0826	peptidase U32
HXT04_00890	COG0657	acetylesterase activity
HXT04_00895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HXT04_00900	COG2890	protein-(glutamine-N5) methyltransferase activity
HXT04_00905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXT04_00910	COG0445	tRNA wobble uridine modification
HXT04_00915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXT04_00915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXT04_00915	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXT04_00915	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXT04_00920	COG1940	carbohydrate kinase activity
HXT04_00950	COG0673	inositol 2-dehydrogenase activity
HXT04_00970	COG3119	arylsulfatase activity
HXT04_00975	COG2188	Transcriptional regulator
HXT04_00980	COG2188	Transcriptional regulator
HXT04_00990	COG0191	fructose-bisphosphate aldolase activity
HXT04_00995	COG0205	6-phosphofructokinase activity
HXT04_01000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXT04_01005	COG1129	ABC transporter
HXT04_01010	COG4213	ABC transporter substrate-binding protein
HXT04_01015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXT04_01025	COG1902	pentaerythritol trinitrate reductase activity
HXT04_01030	COG1970	mechanosensitive ion channel activity
HXT04_01035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXT04_01040	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_01045	COG0371	Dehydrogenase
HXT04_01060	COG3842	ATPase activity
HXT04_01065	COG4115	mRNA cleavage
HXT04_01075	COG2337	Toxic component of a toxin-antitoxin (TA) module
HXT04_01100	COG2315	Protein conserved in bacteria
HXT04_01105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXT04_01110	COG1120	ATPase activity
HXT04_01135	COG1132	(ABC) transporter
HXT04_01140	COG2375	cellular response to nickel ion
HXT04_01140	COG1132	(ABC) transporter
HXT04_01155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXT04_01160	COG1116	anion transmembrane transporter activity
HXT04_01225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXT04_01230	COG0246	Mannitol dehydrogenase
HXT04_01235	COG1802	Transcriptional regulator
HXT04_01255	COG1078	dGTPase activity
HXT04_01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXT04_01285	COG0840	transmembrane signaling receptor activity
HXT04_01290	COG3804	dihydrodipicolinate reductase
HXT04_01295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HXT04_01305	COG0039	L-malate dehydrogenase activity
HXT04_01325	COG0205	6-phosphofructokinase activity
HXT04_01335	COG0840	transmembrane signaling receptor activity
HXT04_01340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HXT04_01345	COG0248	Ppx GppA phosphatase
HXT04_01370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HXT04_01380	COG1045	serine acetyltransferase
HXT04_01385	COG1216	Glycosyl transferase, family 2
HXT04_01390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HXT04_01415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXT04_01425	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXT04_01430	COG0250	Participates in transcription elongation, termination and antitermination
HXT04_01435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXT04_01440	COG0081	regulation of translation
HXT04_01445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXT04_01455	COG0085	RNA polymerase activity
HXT04_01465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXT04_01470	COG0049	tRNA binding
HXT04_01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXT04_01480	COG0051	transcription antitermination factor activity, RNA binding
HXT04_01485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXT04_01490	COG0088	Forms part of the polypeptide exit tunnel
HXT04_01495	COG0089	rRNA binding
HXT04_01500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXT04_01505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXT04_01510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXT04_01515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXT04_01525	COG0255	Belongs to the universal ribosomal protein uL29 family
HXT04_01530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HXT04_01535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXT04_01545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HXT04_01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXT04_01555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HXT04_01560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXT04_01570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXT04_01580	COG0200	Binds to the 23S rRNA
HXT04_01590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXT04_01600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXT04_01605	COG0202	RNA polymerase activity
HXT04_01610	COG0203	ribosomal protein L17
HXT04_01625	COG0559	Belongs to the binding-protein-dependent transport system permease family
HXT04_01645	COG0517	IMP dehydrogenase activity
HXT04_01655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HXT04_01660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXT04_01665	COG0455	bacterial-type flagellum organization
HXT04_01670	COG0793	Belongs to the peptidase S41A family
HXT04_01685	COG2204	response regulator
HXT04_01690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HXT04_01695	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_01720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXT04_01730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HXT04_01740	COG0058	SHG alpha-glucan phosphorylase activity
HXT04_01765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXT04_01770	COG0765	amino acid transport
HXT04_01775	COG1126	abc transporter atp-binding protein
HXT04_01795	COG0659	secondary active sulfate transmembrane transporter activity
HXT04_01805	COG0534	Mate efflux family protein
HXT04_01810	COG2186	Transcriptional regulator
HXT04_01820	COG3959	Transketolase, thiamine diphosphate binding domain
HXT04_01825	COG3958	Transketolase
HXT04_01830	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HXT04_01835	COG0488	(ABC) transporter
HXT04_01850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HXT04_01865	COG2873	o-acetylhomoserine
HXT04_01875	COG1012	belongs to the aldehyde dehydrogenase family
HXT04_01875	COG1454	alcohol dehydrogenase
HXT04_01890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HXT04_01895	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_01900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXT04_01905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXT04_01915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXT04_01915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXT04_01920	COG0613	PHP domain protein
HXT04_01965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXT04_01980	COG4443	Transcriptional Coactivator p15 (PC4)
HXT04_01990	COG1652	LysM domain
HXT04_01995	COG0494	nUDIX hydrolase
HXT04_02030	COG4667	esterase of the alpha-beta hydrolase superfamily
HXT04_02040	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HXT04_02045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXT04_02050	COG0783	Belongs to the Dps family
HXT04_02065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXT04_02115	COG0501	Belongs to the peptidase M48B family
HXT04_02135	COG1175	transmembrane transport
HXT04_02150	COG1283	sodium-dependent phosphate transmembrane transporter activity
HXT04_02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXT04_02170	COG0724	RNA recognition motif
HXT04_02180	COG0740	serine-type endopeptidase activity
HXT04_02200	COG1205	dead DEAH box helicase
HXT04_02200	COG1111	helicase
HXT04_02220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXT04_02235	COG3956	TIGRFAM MazG family protein
HXT04_02240	COG0193	aminoacyl-tRNA hydrolase activity
HXT04_02245	COG2217	Heavy metal translocating P-type atpase
HXT04_02250	COG0640	Transcriptional regulator
HXT04_02270	COG1131	(ABC) transporter
HXT04_02280	COG1959	2 iron, 2 sulfur cluster binding
HXT04_02290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXT04_02295	COG2703	oxygen carrier activity
HXT04_02300	COG2342	PFAM TM1410 hypothetical-related protein
HXT04_02320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXT04_02325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXT04_02330	COG4948	Mandelate Racemase Muconate Lactonizing
HXT04_02335	COG1349	DNA-binding transcription factor activity
HXT04_02340	COG0322	excinuclease ABC activity
HXT04_02355	COG0006	proline dipeptidase activity
HXT04_02360	COG0728	peptidoglycan biosynthetic process
HXT04_02400	COG0811	peptide transport
HXT04_02405	COG0848	biopolymer transport protein
HXT04_02430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HXT04_02430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXT04_02440	COG2885	chlorophyll binding
HXT04_02455	COG1177	transmembrane transport
HXT04_02460	COG1176	ABC-type spermidine putrescine transport system, permease component I
HXT04_02465	COG3842	ATPase activity
HXT04_02475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HXT04_02485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXT04_02505	COG0616	signal peptide processing
HXT04_02520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXT04_02525	COG0800	Aldolase
HXT04_02550	COG1418	mRNA catabolic process
HXT04_02555	COG1137	ATPase activity
HXT04_02570	COG0504	CTP synthase activity
HXT04_02580	COG2201	protein-glutamate methylesterase activity
HXT04_02600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HXT04_02605	COG0739	heme binding
HXT04_02615	COG1595	DNA-templated transcription, initiation
HXT04_02635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXT04_02655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HXT04_02660	COG2011	ABC-type metal ion transport system permease component
HXT04_02740	COG2878	Part of a membrane complex involved in electron transport
HXT04_02745	COG4657	Part of a membrane complex involved in electron transport
HXT04_02750	COG4660	Part of a membrane complex involved in electron transport
HXT04_02760	COG4658	electron transport chain
HXT04_02765	COG4656	Part of a membrane complex involved in electron transport
HXT04_02795	COG1397	ADP-ribosylglycohydrolase
HXT04_02830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HXT04_02835	COG2199	diguanylate cyclase activity
HXT04_02840	COG1862	Preprotein translocase
HXT04_02845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXT04_02850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXT04_02855	COG1063	alcohol dehydrogenase
HXT04_02860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXT04_02865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXT04_02905	COG0826	peptidase U32
HXT04_02960	COG1929	Belongs to the glycerate kinase type-1 family
HXT04_02965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXT04_02975	COG0330	HflC and HflK could
HXT04_02980	COG0330	HflC and HflK could
HXT04_02985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXT04_03000	COG0523	cobalamin synthesis protein
HXT04_03005	COG0137	argininosuccinate synthase activity
HXT04_03010	COG2816	NAD+ diphosphatase activity
HXT04_03015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HXT04_03035	COG4120	Belongs to the binding-protein-dependent transport system permease family
HXT04_03040	COG1122	ATPase activity
HXT04_03045	COG0423	glycine-tRNA ligase activity
HXT04_03065	COG0768	penicillin binding
HXT04_03070	COG0681	Belongs to the peptidase S26 family
HXT04_03075	COG0739	heme binding
HXT04_03090	COG1686	Belongs to the peptidase S11 family
HXT04_03095	COG2252	PERMEase
HXT04_03100	COG0191	fructose-bisphosphate aldolase activity
HXT04_03115	COG0084	hydrolase, TatD family'
HXT04_03120	COG1438	arginine binding
HXT04_03125	COG1193	negative regulation of DNA recombination
HXT04_03130	COG1162	GTPase activity
HXT04_03135	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HXT04_03155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXT04_03170	COG0601	transmembrane transport
HXT04_03185	COG2217	Heavy metal translocating P-type atpase
HXT04_03190	COG1937	Protein conserved in bacteria
HXT04_03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXT04_03220	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HXT04_03235	COG3845	ABC transporter
HXT04_03240	COG1744	ABC transporter substrate-binding protein PnrA-like
HXT04_03265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXT04_03265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXT04_03265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXT04_03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HXT04_03290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXT04_03295	COG0450	alkyl hydroperoxide reductase
HXT04_03300	COG0492	ferredoxin-NADP+ reductase activity
HXT04_03340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXT04_03345	COG0473	3-isopropylmalate dehydrogenase activity
HXT04_03370	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HXT04_03385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXT04_03390	COG4948	Mandelate Racemase Muconate Lactonizing
HXT04_03395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_03405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_03420	COG1879	ABC-type sugar transport system periplasmic component
HXT04_03425	COG1129	ABC transporter
HXT04_03435	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXT04_03495	COG3842	ATPase activity
HXT04_03520	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HXT04_03535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXT04_03540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXT04_03560	COG0681	Belongs to the peptidase S26 family
HXT04_03565	COG0653	protein targeting
HXT04_03585	COG0494	nUDIX hydrolase
HXT04_03595	COG1464	Belongs to the NlpA lipoprotein family
HXT04_03605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXT04_03605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXT04_03605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXT04_03615	COG0564	pseudouridine synthase activity
HXT04_03665	COG0668	transmembrane transport
HXT04_03670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXT04_03675	COG0779	Required for maturation of 30S ribosomal subunits
HXT04_03685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXT04_03690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXT04_03695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXT04_03700	COG0196	riboflavin kinase activity
HXT04_03705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXT04_03710	COG1185	polyribonucleotide nucleotidyltransferase activity
HXT04_03715	COG0756	dUTP diphosphatase activity
HXT04_03730	COG0343	queuine tRNA-ribosyltransferase activity
HXT04_03745	COG0280	phosphate acetyltransferase
HXT04_03770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXT04_03785	COG0800	Aldolase
HXT04_03790	COG1199	ATP-dependent helicase activity
HXT04_03805	COG0268	Binds directly to 16S ribosomal RNA
HXT04_03815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HXT04_03825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HXT04_03830	COG1609	Transcriptional regulator
HXT04_03835	COG0363	glucosamine-6-phosphate deaminase activity
HXT04_03840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_03845	COG2801	Transposase and inactivated derivatives
HXT04_03875	COG2801	Transposase and inactivated derivatives
HXT04_03900	COG1131	(ABC) transporter
HXT04_03915	COG0395	ABC-type sugar transport system, permease component
HXT04_03920	COG1175	transmembrane transport
HXT04_03945	COG0513	Belongs to the DEAD box helicase family
HXT04_03950	COG0488	(ABC) transporter
HXT04_03955	COG0210	DNA helicase
HXT04_03980	COG1104	cysteine desulfurase activity
HXT04_03985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXT04_03995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXT04_04005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXT04_04015	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HXT04_04020	COG1040	competence protein
HXT04_04025	COG0835	chemotaxis
HXT04_04035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXT04_04040	COG0497	DNA recombination
HXT04_04050	COG1744	ABC transporter substrate-binding protein PnrA-like
HXT04_04055	COG3845	ABC transporter
HXT04_04060	COG4603	Belongs to the binding-protein-dependent transport system permease family
HXT04_04065	COG1079	Belongs to the binding-protein-dependent transport system permease family
HXT04_04080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXT04_04085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXT04_04110	COG2001	Belongs to the MraZ family
HXT04_04115	COG0275	rRNA processing
HXT04_04125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HXT04_04160	COG0758	DNA mediated transformation
HXT04_04160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXT04_04165	COG0551	DNA topoisomerase type I activity
HXT04_04165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HXT04_04170	COG4974	Belongs to the 'phage' integrase family
HXT04_04175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HXT04_04180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HXT04_04215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXT04_04215	COG0248	Ppx GppA phosphatase
HXT04_04225	COG0583	DNA-binding transcription factor activity
HXT04_04230	COG1766	The M ring may be actively involved in energy transduction
HXT04_04240	COG1317	bacterial-type flagellum organization
HXT04_04245	COG1157	protein secretion by the type III secretion system
HXT04_04255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXT04_04260	COG2084	Dehydrogenase
HXT04_04280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXT04_04290	COG1702	phosphate starvation-inducible protein PhoH
HXT04_04295	COG1480	7TM receptor with intracellular HD hydrolase
HXT04_04300	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HXT04_04335	COG0552	protein localization to endoplasmic reticulum
HXT04_04345	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXT04_04350	COG1136	(ABC) transporter
HXT04_04365	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HXT04_04375	COG3977	Valine--pyruvate aminotransferase
HXT04_04380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HXT04_04390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXT04_04400	COG1904	glucuronate isomerase
HXT04_04405	COG0670	Belongs to the BI1 family
HXT04_04410	COG0006	proline dipeptidase activity
HXT04_04420	COG1966	Carbon starvation protein
HXT04_04430	COG1373	ATPase (AAA superfamily
HXT04_04460	COG0626	cystathionine gamma-synthase activity
HXT04_04505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HXT04_04525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HXT04_04560	COG1234	tRNA 3'-trailer cleavage
HXT04_04570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXT04_04595	COG1136	(ABC) transporter
HXT04_04605	COG0632	four-way junction helicase activity
HXT04_04610	COG2255	four-way junction helicase activity
HXT04_04615	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HXT04_04635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXT04_04660	COG1129	ABC transporter
HXT04_04665	COG1129	ABC transporter
HXT04_04670	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXT04_04685	COG1802	Transcriptional regulator
HXT04_04695	COG1366	Belongs to the anti-sigma-factor antagonist family
HXT04_04720	COG2972	Histidine kinase
HXT04_04725	COG0662	Cupin 2, conserved barrel domain protein
HXT04_04725	COG2207	Transcriptional regulator
HXT04_04735	COG1175	transmembrane transport
HXT04_04740	COG3833	ABC-type maltose transport systems, permease component
HXT04_04750	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HXT04_04755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXT04_04760	COG1722	exodeoxyribonuclease VII activity
HXT04_04765	COG1570	exodeoxyribonuclease VII activity
HXT04_04770	COG0731	radical SAM domain protein
HXT04_04780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXT04_04790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXT04_04790	COG1388	LysM domain
HXT04_04820	COG1904	glucuronate isomerase
HXT04_04825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_04835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_04840	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_04845	COG0473	3-isopropylmalate dehydrogenase activity
HXT04_04845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXT04_04850	COG1312	Catalyzes the dehydration of D-mannonate
HXT04_04860	COG3330	Domain of unknown function (DUF4912)
HXT04_04915	COG2801	Transposase and inactivated derivatives
HXT04_04955	COG2211	Major facilitator Superfamily
HXT04_04965	COG2169	Transcriptional regulator
HXT04_04990	COG0730	response to heat
HXT04_04995	COG1053	succinate dehydrogenase
HXT04_04995	COG3976	FMN-binding domain protein
HXT04_05000	COG3976	FMN-binding domain protein
HXT04_05000	COG1053	succinate dehydrogenase
HXT04_05000	COG0431	NADPH-dependent FMN reductase
HXT04_05010	COG1724	mRNA binding
HXT04_05020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXT04_05030	COG0470	DNA polymerase III
HXT04_05035	COG3852	Histidine kinase
HXT04_05040	COG2204	response regulator
HXT04_05045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HXT04_05050	COG4786	Flagellar basal body rod
HXT04_05090	COG3706	GGDEF domain
HXT04_05100	COG2348	transferase activity, transferring amino-acyl groups
HXT04_05130	COG0747	negative chemotaxis
HXT04_05140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXT04_05145	COG0444	Belongs to the ABC transporter superfamily
HXT04_05150	COG4608	Belongs to the ABC transporter superfamily
HXT04_05170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXT04_05175	COG0285	dihydrofolate synthase activity
HXT04_05185	COG0617	tRNA 3'-terminal CCA addition
HXT04_05240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HXT04_05245	COG0358	DNA primase activity
HXT04_05250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXT04_05270	COG1077	Cell shape determining protein MreB Mrl
HXT04_05285	COG0768	penicillin binding
HXT04_05290	COG0772	Belongs to the SEDS family
HXT04_05300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXT04_05335	COG0813	purine-nucleoside phosphorylase activity
HXT04_05345	COG1482	cell wall glycoprotein biosynthetic process
HXT04_05350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXT04_05355	COG0217	transcriptional regulatory protein
HXT04_05360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HXT04_05380	COG0297	glycogen (starch) synthase activity
HXT04_05390	COG0750	zinc metalloprotease
HXT04_05395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXT04_05400	COG0575	Belongs to the CDS family
HXT04_05405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXT04_05410	COG0233	cytoplasmic translational termination
HXT04_05415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXT04_05420	COG0052	Belongs to the universal ribosomal protein uS2 family
HXT04_05425	COG0424	maF-like protein
HXT04_05435	COG1413	lyase activity
HXT04_05445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HXT04_05450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXT04_05460	COG0571	ribonuclease III activity
HXT04_05485	COG1234	tRNA 3'-trailer cleavage
HXT04_05520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXT04_05530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HXT04_05540	COG0564	pseudouridine synthase activity
HXT04_05545	COG0564	pseudouridine synthase activity
HXT04_05595	COG1151	hydroxylamine reductase activity
HXT04_05615	COG0395	ABC-type sugar transport system, permease component
HXT04_05620	COG1175	transmembrane transport
HXT04_05630	COG4948	Mandelate Racemase Muconate Lactonizing
HXT04_05635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HXT04_05650	COG0460	homoserine dehydrogenase
HXT04_05650	COG0527	aspartate kinase activity
HXT04_05655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXT04_05660	COG3842	ATPase activity
HXT04_05665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXT04_05675	COG2207	Transcriptional regulator
HXT04_05675	COG4753	response regulator
HXT04_05680	COG2972	Histidine kinase
HXT04_05685	COG1653	transport
HXT04_05690	COG1175	transmembrane transport
HXT04_05695	COG0395	ABC-type sugar transport system, permease component
HXT04_05700	COG1486	melibiose metabolic process
HXT04_05705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXT04_05775	COG0617	tRNA 3'-terminal CCA addition
HXT04_05785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXT04_05795	COG3386	PFAM SMP-30 Gluconolaconase
HXT04_05810	COG0305	Participates in initiation and elongation during chromosome replication
HXT04_05820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXT04_05825	COG0629	single-stranded DNA binding
HXT04_05830	COG0360	Binds together with S18 to 16S ribosomal RNA
HXT04_05860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXT04_05870	COG1102	Psort location Cytoplasmic, score
HXT04_05875	COG0426	domain, Protein
HXT04_05915	COG0463	Glycosyl transferase, family 2
HXT04_05940	COG0706	membrane insertase activity
HXT04_05945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXT04_05970	COG2801	Transposase and inactivated derivatives
HXT04_06025	COG0629	single-stranded DNA binding
HXT04_06050	COG3723	Recombinational DNA repair protein, rece pathway
HXT04_06065	COG5377	YqaJ viral recombinase family
HXT04_06100	COG3118	belongs to the thioredoxin family
HXT04_06105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HXT04_06115	COG1269	ATP hydrolysis coupled proton transport
HXT04_06120	COG1394	ATPase activity, coupled to movement of substances
HXT04_06125	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HXT04_06130	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HXT04_06140	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HXT04_06165	COG1191	sigma factor activity
HXT04_06185	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXT04_06190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXT04_06195	COG1684	flagellar biosynthetic protein fliR
HXT04_06200	COG1987	bacterial-type flagellum assembly
HXT04_06205	COG1338	Plays a role in the flagellum-specific transport system
HXT04_06220	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXT04_06225	COG1580	Controls the rotational direction of flagella during chemotaxis
HXT04_06230	COG1360	Flagellar Motor Protein
HXT04_06245	COG0745	RESPONSE REGULATOR receiver
HXT04_06250	COG5002	protein histidine kinase activity
HXT04_06255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXT04_06265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXT04_06275	COG0009	L-threonylcarbamoyladenylate synthase
HXT04_06315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HXT04_06325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXT04_06450	COG1022	Amp-dependent synthetase and ligase
HXT04_06460	COG0301	tRNA thio-modification
HXT04_06480	COG0438	transferase activity, transferring glycosyl groups
HXT04_06485	COG1573	uracil-dna glycosylase
HXT04_06490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HXT04_06495	COG0101	tRNA pseudouridine synthase activity
HXT04_06505	COG0736	holo-[acyl-carrier-protein] synthase activity
HXT04_06515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HXT04_06520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXT04_06525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXT04_06530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXT04_06540	COG1053	succinate dehydrogenase
HXT04_06540	COG3976	FMN-binding domain protein
HXT04_06550	COG3421	Type III restriction
HXT04_06555	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HXT04_06560	COG3620	sequence-specific DNA binding
HXT04_06580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HXT04_06585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HXT04_06585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HXT04_06590	COG0739	heme binding
HXT04_06600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXT04_06605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXT04_06620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXT04_06635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HXT04_06640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXT04_06645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HXT04_06650	COG1268	BioY protein
HXT04_06655	COG1122	ATPase activity
HXT04_06660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HXT04_06685	COG3549	Plasmid maintenance system killer
HXT04_06705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXT04_06730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXT04_06750	COG4821	SIS domain
HXT04_06780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXT04_06820	COG0802	atpase or kinase
HXT04_06825	COG1214	PFAM Peptidase M22, glycoprotease
HXT04_06830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HXT04_06835	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HXT04_06840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXT04_06860	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_06870	COG4948	Mandelate Racemase Muconate Lactonizing
HXT04_06875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_06875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_06885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_06890	COG0492	ferredoxin-NADP+ reductase activity
HXT04_06925	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXT04_06930	COG0740	serine-type endopeptidase activity
HXT04_06935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HXT04_06940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HXT04_06950	COG4565	transcriptional regulatory protein
HXT04_06955	COG3290	protein histidine kinase activity
HXT04_06965	COG4149	molybdate abc transporter
HXT04_06970	COG3842	ATPase activity
HXT04_06985	COG4806	L-rhamnose isomerase
HXT04_06990	COG0436	Aminotransferase
HXT04_06995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HXT04_07000	COG0396	ATPase activity
HXT04_07010	COG0719	Fe-S assembly protein
HXT04_07020	COG0537	adenosine 5'-monophosphoramidase activity
HXT04_07030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_07040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_07040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_07045	COG0579	oxidoreductase
HXT04_07050	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXT04_07060	COG1177	transmembrane transport
HXT04_07065	COG3842	ATPase activity
HXT04_07070	COG1840	ABC-type Fe3 transport system, periplasmic component
HXT04_07085	COG0534	Mate efflux family protein
HXT04_07095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HXT04_07110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXT04_07140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXT04_07150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXT04_07155	COG1132	(ABC) transporter
HXT04_07170	COG1309	transcriptional regulator
HXT04_07180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HXT04_07185	COG0419	ATPase involved in DNA repair
HXT04_07195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXT04_07210	COG0542	response to heat
HXT04_07230	COG0557	exoribonuclease II activity
HXT04_07250	COG0588	phosphoglycerate mutase activity
HXT04_07255	COG2226	methyltransferase
HXT04_07290	COG0733	neurotransmitter:sodium symporter activity
HXT04_07300	COG1349	DNA-binding transcription factor activity
HXT04_07305	COG1070	Carbohydrate kinase
HXT04_07310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXT04_07315	COG2373	Large extracellular alpha-helical protein
HXT04_07325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXT04_07340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXT04_07365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXT04_07385	COG2207	Transcriptional regulator
HXT04_07385	COG3708	Transcriptional regulator
HXT04_07420	COG1285	pathogenesis
HXT04_07445	COG2972	Histidine kinase
HXT04_07450	COG4753	response regulator
HXT04_07450	COG2207	Transcriptional regulator
HXT04_07455	COG1840	ABC-type Fe3 transport system, periplasmic component
HXT04_07475	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HXT04_07500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXT04_07510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HXT04_07515	COG2089	acid synthase
HXT04_07520	COG0124	histidyl-tRNA synthetase
HXT04_07540	COG2604	Protein of unknown function DUF115
HXT04_07545	COG0481	GTPase activity
HXT04_07550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXT04_07560	COG0037	tRNA processing
HXT04_07565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXT04_07580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXT04_07610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXT04_07615	COG1979	alcohol dehydrogenase
HXT04_07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXT04_07625	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXT04_07640	COG1773	rubredoxin
HXT04_07640	COG1592	Rubrerythrin
HXT04_07650	COG0666	response to abiotic stimulus
HXT04_07660	COG4608	Belongs to the ABC transporter superfamily
HXT04_07665	COG0444	Belongs to the ABC transporter superfamily
HXT04_07715	COG0018	arginyl-trna synthetase
HXT04_07770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXT04_07780	COG0335	large ribosomal subunit rRNA binding
HXT04_07785	COG0336	Belongs to the RNA methyltransferase TrmD family
HXT04_07795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HXT04_07800	COG1837	Belongs to the UPF0109 family
HXT04_07860	COG0765	amino acid transport
HXT04_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXT04_07870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HXT04_07885	COG3177	Filamentation induced by cAMP protein fic
HXT04_07890	COG0028	Belongs to the TPP enzyme family
HXT04_07895	COG0129	dihydroxy-acid dehydratase activity
HXT04_07940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXT04_07955	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HXT04_07960	COG1671	Belongs to the UPF0178 family
HXT04_07965	COG0784	Response regulator, receiver
HXT04_07965	COG3437	response regulator, receiver
HXT04_07970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXT04_07970	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HXT04_07995	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXT04_07995	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXT04_07995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXT04_07995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXT04_08010	COG0426	domain, Protein
HXT04_08010	COG1773	rubredoxin
HXT04_08015	COG4221	oxidoreductase activity
HXT04_08020	COG0037	tRNA processing
HXT04_08025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HXT04_08030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HXT04_08040	COG2201	protein-glutamate methylesterase activity
HXT04_08050	COG0835	chemotaxis
HXT04_08055	COG0643	Histidine kinase
HXT04_08055	COG2198	Histidine kinase
HXT04_08065	COG0436	Aminotransferase
HXT04_08070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HXT04_08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXT04_08115	COG0475	glutathione-regulated potassium exporter activity
HXT04_08125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HXT04_08140	COG1196	nuclear chromosome segregation
HXT04_08160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXT04_08200	COG2233	PERMEase
HXT04_08215	COG0525	valine-tRNA ligase activity
HXT04_08265	COG3842	ATPase activity
HXT04_08270	COG1840	ABC-type Fe3 transport system, periplasmic component
HXT04_08295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXT04_08300	COG4115	mRNA cleavage
HXT04_08320	COG1509	lysine 2,3-aminomutase activity
HXT04_08330	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HXT04_08335	COG0534	Mate efflux family protein
HXT04_08345	COG1187	pseudouridine synthase activity
HXT04_08350	COG0372	Belongs to the citrate synthase family
HXT04_08355	COG0024	Methionine aminopeptidase
HXT04_08360	COG0484	heat shock protein binding
HXT04_08370	COG1394	ATPase activity, coupled to movement of substances
HXT04_08375	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HXT04_08380	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HXT04_08400	COG1269	ATP hydrolysis coupled proton transport
HXT04_08415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXT04_08415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXT04_08415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXT04_08420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXT04_08425	COG0149	triose-phosphate isomerase activity
HXT04_08430	COG0126	phosphoglycerate kinase activity
HXT04_08435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXT04_08455	COG1609	Transcriptional regulator
HXT04_08460	COG0363	glucosamine-6-phosphate deaminase activity
HXT04_08465	COG0363	glucosamine-6-phosphate deaminase activity
HXT04_08485	COG3604	Transcriptional regulator
HXT04_08490	COG0539	negative regulation of cytoplasmic translation
HXT04_08500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HXT04_08505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HXT04_08510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXT04_08515	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXT04_08535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXT04_08545	COG1747	RNA polymerase binding
HXT04_08545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXT04_08550	COG0708	Exodeoxyribonuclease III
HXT04_08575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXT04_08615	COG3328	transposase activity
HXT04_08650	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HXT04_08685	COG1215	transferase activity, transferring glycosyl groups
HXT04_08720	COG1215	transferase activity, transferring glycosyl groups
HXT04_08730	COG1454	alcohol dehydrogenase
HXT04_08740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXT04_08755	COG4310	Domain of unknown function (DUF2172)
HXT04_08760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HXT04_08765	COG2089	acid synthase
HXT04_08785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXT04_08790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXT04_08815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXT04_08855	COG0148	phosphopyruvate hydratase activity
HXT04_08865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HXT04_08870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXT04_08875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HXT04_08880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HXT04_08890	COG4452	Inner membrane protein CreD
HXT04_08895	COG0840	transmembrane signaling receptor activity
HXT04_08900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HXT04_08925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXT04_08930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXT04_08935	COG0215	cysteine-tRNA ligase activity
HXT04_08955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HXT04_08965	COG2003	Belongs to the UPF0758 family
HXT04_08980	COG0556	nucleotide-excision repair
HXT04_08985	COG1120	ATPase activity
HXT04_08990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXT04_09005	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HXT04_09020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXT04_09025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_09025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_09040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXT04_09070	COG1349	DNA-binding transcription factor activity
HXT04_09090	COG0395	ABC-type sugar transport system, permease component
HXT04_09095	COG1175	transmembrane transport
HXT04_09155	COG1129	ABC transporter
HXT04_09160	COG1609	Transcriptional regulator
HXT04_09165	COG1609	Transcriptional regulator
HXT04_09170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXT04_09175	COG1882	Formate acetyltransferase
HXT04_09200	COG0656	L-ascorbic acid biosynthetic process
HXT04_09205	COG1739	Uncharacterized protein family UPF0029
HXT04_09245	COG0495	leucyl-tRNA aminoacylation
HXT04_09260	COG1366	Belongs to the anti-sigma-factor antagonist family
HXT04_09275	COG0484	heat shock protein binding
HXT04_09280	COG0443	Heat shock 70 kDa protein
HXT04_09285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXT04_09290	COG0564	pseudouridine synthase activity
HXT04_09310	COG0563	adenylate kinase activity
HXT04_09325	COG0513	Belongs to the DEAD box helicase family
HXT04_09350	COG1846	Transcriptional regulator
HXT04_09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXT04_09360	COG1469	GTP cyclohydrolase I activity
HXT04_09365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXT04_09390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXT04_09395	COG1830	Aldolase
HXT04_09400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_09400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_09405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_09425	COG1349	DNA-binding transcription factor activity
HXT04_09435	COG0154	amidase activity
HXT04_09445	COG0017	Asparaginyl-tRNA synthetase
HXT04_09450	COG0504	CTP synthase activity
HXT04_09460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXT04_09465	COG0564	pseudouridine synthase activity
HXT04_09475	COG0765	amino acid transport
HXT04_09480	COG1126	abc transporter atp-binding protein
HXT04_09485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXT04_09490	COG0534	Mate efflux family protein
HXT04_09500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HXT04_09505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXT04_09510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXT04_09520	COG1070	Carbohydrate kinase
HXT04_09525	COG2115	Belongs to the xylose isomerase family
HXT04_09535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXT04_09540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXT04_09545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXT04_09550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXT04_09555	COG1121	(ABC) transporter
HXT04_09560	COG0803	Belongs to the bacterial solute-binding protein 9 family
HXT04_09590	COG1373	ATPase (AAA superfamily
HXT04_09600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXT04_09605	COG0107	imidazoleglycerol-phosphate synthase activity
HXT04_09615	COG0720	synthase
HXT04_09620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXT04_09625	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXT04_09630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXT04_09645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HXT04_09650	COG0724	RNA recognition motif
HXT04_09675	COG0210	DNA helicase
HXT04_09680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXT04_09690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HXT04_09715	COG2885	chlorophyll binding
HXT04_09725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXT04_09730	COG1121	(ABC) transporter
HXT04_09735	COG0534	Mate efflux family protein
HXT04_09745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HXT04_09755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXT04_09760	COG0800	Aldolase
HXT04_09765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXT04_09770	COG2755	lipolytic protein G-D-S-L family
HXT04_09775	COG0517	IMP dehydrogenase activity
HXT04_09775	COG0516	GMP reductase activity
HXT04_09780	COG1053	succinate dehydrogenase
HXT04_09790	COG0587	DNA-directed DNA polymerase activity
HXT04_09795	COG0762	integral membrane protein
HXT04_09800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HXT04_09805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXT04_09810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXT04_09820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXT04_09825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXT04_09830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXT04_09840	COG1773	rubredoxin
HXT04_09855	COG1733	regulation of RNA biosynthetic process
HXT04_09860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXT04_09865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXT04_09885	COG0328	RNA-DNA hybrid ribonuclease activity
HXT04_09890	COG0295	cytidine deaminase activity
HXT04_09895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXT04_09905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXT04_09925	COG1028	Short-chain dehydrogenase reductase Sdr
HXT04_09930	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HXT04_09935	COG0693	protein deglycase activity
HXT04_09940	COG4565	transcriptional regulatory protein
HXT04_09955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXT04_09960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXT04_09965	COG0484	heat shock protein binding
HXT04_09970	COG1193	negative regulation of DNA recombination
HXT04_10000	COG0714	Associated with various cellular activities
HXT04_10040	COG1127	ABC transporter
HXT04_10070	COG0357	Ribosomal RNA small subunit methyltransferase G
HXT04_10080	COG0436	Aminotransferase
HXT04_10085	COG1522	sequence-specific DNA binding
HXT04_10090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXT04_10095	COG3858	chitin binding
HXT04_10120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HXT04_10125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HXT04_10135	COG1051	belongs to the nudix hydrolase family
HXT04_10150	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HXT04_10160	COG0166	Belongs to the GPI family
HXT04_10170	COG2801	Transposase and inactivated derivatives
HXT04_10175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HXT04_10180	COG1477	protein flavinylation
HXT04_10185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXT04_10195	COG1272	protein, Hemolysin III
HXT04_10200	COG0730	response to heat
HXT04_10205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXT04_10210	COG3012	SEC-C Motif Domain Protein
HXT04_10215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXT04_10245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HXT04_10265	COG2721	sulfolactate sulfo-lyase activity
HXT04_10270	COG0246	Mannitol dehydrogenase
HXT04_10275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_10275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_10285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_10290	COG1063	alcohol dehydrogenase
HXT04_10315	COG1573	uracil-dna glycosylase
HXT04_10335	COG0579	oxidoreductase
HXT04_10385	COG0501	Belongs to the peptidase M48B family
HXT04_10390	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HXT04_10405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXT04_10420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXT04_10430	COG1309	transcriptional regulator
HXT04_10435	COG0116	Belongs to the methyltransferase superfamily
HXT04_10440	COG0167	dihydroorotate dehydrogenase activity
HXT04_10445	COG0284	orotidine-5'-phosphate decarboxylase activity
HXT04_10450	COG0318	PFAM AMP-dependent synthetase and ligase
HXT04_10500	COG2207	Transcriptional regulator
HXT04_10500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXT04_10505	COG4209	transmembrane transport
HXT04_10510	COG0395	ABC-type sugar transport system, permease component
HXT04_10515	COG1653	transport
HXT04_10525	COG1968	undecaprenyl-diphosphatase activity
HXT04_10530	COG1132	(ABC) transporter
HXT04_10540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HXT04_10540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HXT04_10550	COG0151	Belongs to the GarS family
HXT04_10560	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HXT04_10565	COG3250	beta-galactosidase activity
HXT04_10570	COG0395	ABC-type sugar transport system, permease component
HXT04_10575	COG1175	transmembrane transport
HXT04_10585	COG1653	transport
HXT04_10590	COG1609	Transcriptional regulator
HXT04_10590	COG2207	Transcriptional regulator
HXT04_10605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXT04_10610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXT04_10615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HXT04_10625	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HXT04_10630	COG0641	radical SAM
HXT04_10635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXT04_10640	COG3507	Belongs to the glycosyl hydrolase 43 family
HXT04_10670	COG2382	esterase
HXT04_10675	COG1175	transmembrane transport
HXT04_10680	COG0395	ABC-type sugar transport system, permease component
HXT04_10695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXT04_10705	COG1121	(ABC) transporter
HXT04_10725	COG2183	response to ionizing radiation
HXT04_10755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXT04_10780	COG3116	cell division
HXT04_10780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXT04_10785	COG0084	hydrolase, TatD family'
HXT04_10790	COG0739	heme binding
HXT04_10805	COG1774	PSP1 C-terminal conserved region
HXT04_10820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HXT04_10850	COG0442	prolyl-tRNA aminoacylation
HXT04_10875	COG1733	regulation of RNA biosynthetic process
HXT04_10935	COG0281	malic enzyme
HXT04_10950	COG0488	(ABC) transporter
HXT04_10955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXT04_10960	COG1234	tRNA 3'-trailer cleavage
HXT04_10980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXT04_10995	COG1312	Catalyzes the dehydration of D-mannonate
HXT04_11010	COG4948	Mandelate Racemase Muconate Lactonizing
HXT04_11035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXT04_11045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXT04_11045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXT04_11055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXT04_11065	COG2084	Dehydrogenase
HXT04_11225	COG2197	response regulator
HXT04_11275	COG1733	regulation of RNA biosynthetic process
HXT04_11290	COG3321	synthase
HXT04_11290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXT04_11290	COG0604	alcohol dehydrogenase
HXT04_11290	COG4221	oxidoreductase activity
HXT04_11310	COG2226	methyltransferase
HXT04_11355	COG0110	maltose O-acetyltransferase activity
HXT04_11380	COG1132	(ABC) transporter
HXT04_11380	COG2375	cellular response to nickel ion
HXT04_11430	COG3048	D-serine ammonia-lyase activity
HXT04_11445	COG1053	succinate dehydrogenase
HXT04_11445	COG3976	FMN-binding domain protein
HXT04_11455	COG1022	Amp-dependent synthetase and ligase
HXT04_11465	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HXT04_11465	COG3264	Mechanosensitive ion channel
HXT04_11475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HXT04_11485	COG1674	ftsk spoiiie
HXT04_11490	COG0205	6-phosphofructokinase activity
HXT04_11500	COG1609	Transcriptional regulator
HXT04_11515	COG2972	Histidine kinase
HXT04_11525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXT04_11545	COG0697	spore germination
HXT04_11560	COG0765	amino acid transport
HXT04_11575	COG0492	ferredoxin-NADP+ reductase activity
HXT04_11580	COG2502	aspartate--ammonia ligase
HXT04_11590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXT04_11595	COG1070	Carbohydrate kinase
HXT04_11605	COG1129	ABC transporter
HXT04_11610	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXT04_11615	COG1879	ABC-type sugar transport system periplasmic component
HXT04_11635	COG0673	inositol 2-dehydrogenase activity
HXT04_11665	COG3549	Plasmid maintenance system killer
HXT04_11700	COG4115	mRNA cleavage
HXT04_11715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXT04_11735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXT04_11740	COG0326	Molecular chaperone. Has ATPase activity
HXT04_11780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXT04_11785	COG0187	DNA topoisomerase II activity