locus-tag class description TPE_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) TPE_0003 ENOG4105CEU Arginine dihydrolase TPE_0005 ENOG4105C5S asparaginyl-tRNA synthetase TPE_0006 ENOG4105DZ1 carboxypeptidase TPE_0007 ENOG41081F0 Precorrin-8x methylmutase TPE_0009 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TPE_0021 ENOG4105CJR Integral membrane protein (MviN TPE_0022 ENOG4105D6U Sodium Glutamate Symporter TPE_0027 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TPE_0028 ENOG41068UM RNA Polymerase TPE_0033 ENOG4107QKZ Ompa motb domain protein TPE_0034 ENOG4108N3W hemolysin secretion protein TPE_0035 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) TPE_0036 ENOG4105FE9 pseudouridine synthase TPE_0037 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) TPE_0038 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) TPE_0041 ENOG4107QJD pyruvate phosphate dikinase TPE_0042 ENOG4108SXE TPE_0043 ENOG41073RW Cytoplasmic filament protein A TPE_0044 ENOG4105YQK von Willebrand factor type A domain TPE_0045 ENOG4106BN6 TPE_0046 ENOG4107YZP Rhodanese domain protein TPE_0049 ENOG4105EHG Permease protein TPE_0050 ENOG4105E0A ABC, transporter TPE_0064 ENOG4105C94 Transporter TPE_0066 ENOG4105DQ5 transport system permease protein TPE_0068 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TPE_0071 ENOG4105MAX Superoxide reductase TPE_0073 ENOG4105UQX Mate efflux family protein TPE_0131 ENOG4108JMM (ABC) transporter TPE_0133 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_0135 ENOG4105DEF Extracellular solute-binding protein, family 5 TPE_0136 ENOG4105E7U AraC family transcriptional regulator TPE_0137 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0148 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) TPE_0149 ENOG4107QMG Nad synthetase TPE_0154 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) TPE_0156 ENOG41090Q2 TPE_0162 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0163 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TPE_0164 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) TPE_0166 ENOG4105WPN DNA integration recombination invertion protein TPE_0168 ENOG4105CJN penicillin-binding protein TPE_0172 ENOG4108V1T peptidylprolyl cis-trans isomerase TPE_0173 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) TPE_0174 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) TPE_0176 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TPE_0177 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TPE_0178 ENOG41069X2 TPE_0180 ENOG4105C0H protease TPE_0182 ENOG4105F6J Alpha beta hydrolase fold TPE_0187 ENOG4105E4P ATPase (AAA TPE_0188 ENOG4105J5G Transferase hexapeptide repeat containing protein TPE_0191 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TPE_0195 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase TPE_0196 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TPE_0201 ENOG4105D2T synthase TPE_0202 ENOG4105F0R Cytidylyltransferase TPE_0207 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase TPE_0208 ENOG4107QQG Dehydrogenase TPE_0211 ENOG4105KPE licD family TPE_0216 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase TPE_0218 ENOG4105C1B dTDP-glucose 4-6-dehydratase TPE_0221 ENOG4105EJQ L-serine dehydratase TPE_0226 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TPE_0241 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TPE_0244 ENOG4105C2J ABC transporter TPE_0247 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator TPE_0248 ENOG4105C4Y ABC transporter TPE_0249 ENOG4105CPK Glycosyl transferase (Group 1 TPE_0250 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TPE_0251 ENOG4107RCV ABC transporter, permease TPE_0252 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) TPE_0254 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TPE_0255 ENOG4105E2Y ABC, transporter TPE_0264 ENOG4107ZYR domain protein TPE_0265 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TPE_0266 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) TPE_0268 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TPE_0270 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TPE_0271 ENOG410691R Modulates RecA activity (By similarity) TPE_0272 ENOG4108UJD 30S ribosomal protein S9 TPE_0273 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) TPE_0277 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0279 ENOG4105CG6 trap dicarboxylate transporter dctm subunit TPE_0281 ENOG41081IW Inherit from COG: Membrane TPE_0288 ENOG4105EHG Permease protein TPE_0302 ENOG4105ECW sulfate abc transporter TPE_0304 ENOG4105Z8J TPE_0308 ENOG4108JJB ABC transporter TPE_0309 ENOG4107ZYJ bioY protein TPE_0312 ENOG4108I7Y domain protein TPE_0313 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TPE_0316 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) TPE_0323 ENOG4105C1A potassium transporter peripheral membrane TPE_0324 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) TPE_0329 ENOG41063XV TPE_0330 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase TPE_0334 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY TPE_0338 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) TPE_0341 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) TPE_0344 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane TPE_0346 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) TPE_0353 ENOG41089UC methyltransferase, type 11 TPE_0356 ENOG4106J2Q Uncharacterised protein family (UPF0164) TPE_0357 ENOG4106NKH TPE_0359 ENOG4108IUW ABC transporter TPE_0363 ENOG4105BZ1 (ABC) transporter TPE_0364 ENOG4105BZ1 (ABC) transporter TPE_0366 ENOG4105CD3 dihydroorotase TPE_0367 ENOG4105EHZ conserved protein UCP016719 TPE_0372 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TPE_0375 ENOG4108JJB ABC transporter TPE_0379 ENOG4105CE1 Ferrous iron transport protein b TPE_0387 ENOG4105C9U ATP-dependent DNA helicase RecQ TPE_0394 ENOG4106N2C TPE_0395 ENOG4105CGH 5'-nucleotidase TPE_0398 ENOG4105DFA alanine racemase domain protein TPE_0400 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) TPE_0401 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) TPE_0403 ENOG4107QYI peptidase TPE_0404 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TPE_0410 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) TPE_0411 ENOG4105KZ7 phosphocarrier protein hpr TPE_0412 ENOG4106KIQ TPE_0414 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TPE_0415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TPE_0416 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) TPE_0417 ENOG4105C59 p-type ATPase TPE_0419 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TPE_0420 ENOG4105BZ1 (ABC) transporter TPE_0422 ENOG4105KME endoribonuclease L-psp TPE_0423 ENOG4105EIB trna rrna methyltransferase TPE_0425 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) TPE_0427 ENOG4105K46 50S ribosomal protein l27 TPE_0428 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TPE_0429 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) TPE_0433 ENOG4105CIZ coA-substrate-specific enzyme activase TPE_0434 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TPE_0443 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TPE_0444 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) TPE_0445 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) TPE_0446 ENOG4108VZM 50s ribosomal protein L10 TPE_0447 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) TPE_0448 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TPE_0449 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TPE_0453 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TPE_0457 ENOG4105C9B Cysteine desulfurase TPE_0461 ENOG4105C22 threonyL-tRNA synthetase TPE_0462 ENOG4105BZU Histidine kinase TPE_0463 ENOG4105CQ7 ATP-dependent helicase TPE_0465 ENOG4105CKU formyltetrahydrofolate synthetase TPE_0467 ENOG4105DER m42 family TPE_0470 ENOG4108IQE Amp-dependent synthetase and ligase TPE_0472 ENOG4108RZE Tetr family transcriptional regulator TPE_0473 ENOG4105D6U Sodium Glutamate Symporter TPE_0474 ENOG4105BZ1 (ABC) transporter TPE_0477 ENOG4108JJB ABC transporter TPE_0478 ENOG4105BZ1 (ABC) transporter TPE_0480 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) TPE_0481 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) TPE_0482 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) TPE_0485 ENOG4105D48 metallophosphoesterase TPE_0488 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TPE_0490 ENOG4105C3J Cysteine desulfurase TPE_0491 ENOG4105D49 3-dehydroquinate synthase TPE_0492 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TPE_0493 ENOG4108JU6 CBS domain protein TPE_0494 ENOG4105C37 (CBS) domain TPE_0496 ENOG4108J59 Extracellular solute-binding protein, family 5 TPE_0497 ENOG4108JQ7 (ABC) transporter TPE_0499 ENOG4108J59 Extracellular solute-binding protein, family 5 TPE_0500 ENOG4105DEF Extracellular solute-binding protein, family 5 TPE_0501 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_0502 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component TPE_0509 ENOG4105BZU Histidine kinase TPE_0510 ENOG4105BZU Histidine kinase TPE_0516 ENOG4108UHU Aldolase TPE_0523 ENOG4105BZU Histidine kinase TPE_0524 ENOG4105M3Z response regulator TPE_0526 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TPE_0529 ENOG4105C5X domain protein TPE_0532 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TPE_0533 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) TPE_0534 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) TPE_0536 ENOG4105CZV ABC transporter TPE_0539 ENOG4105C6E dna polymerase iii TPE_0540 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) TPE_0543 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TPE_0544 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein TPE_0547 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase TPE_0548 ENOG4106PMH Extracellular solute-binding protein family 3 TPE_0551 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TPE_0554 ENOG4105I03 Flagellin TPE_0555 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0558 ENOG4105F8V Hydrolase, tatD family TPE_0559 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TPE_0561 ENOG4105F8J Adenylate Guanylate cyclase TPE_0563 ENOG4108Z29 Flavodoxin TPE_0567 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase TPE_0568 ENOG4105ESV Glycosyl transferase, family 4 TPE_0569 ENOG4105FZW flagellar biosynthesis regulator FlhF TPE_0572 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TPE_0578 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TPE_0579 ENOG4105F4G Membrane TPE_0580 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) TPE_0582 ENOG4105K63 Thioredoxin TPE_0584 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) TPE_0586 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TPE_0587 ENOG4105MJ2 Competence protein TPE_0588 ENOG4105C75 arginyL-tRNA synthetase TPE_0589 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TPE_0598 ENOG4105D6S protein involved in catabolism of external DNA TPE_0599 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TPE_0601 ENOG4105CN7 Flagellar biosynthetic protein FliP TPE_0603 ENOG4105DD5 Flagellar motor switch protein TPE_0604 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TPE_0605 ENOG41064SM flagellar basal body-associated protein flil TPE_0606 ENOG4107XSU flagellar motor protein motb TPE_0607 ENOG4107R0U MotA TolQ exbB proton channel TPE_0609 ENOG4105BZE flagellar hook protein, FlgE TPE_0610 ENOG410822I Flagellar hook capping protein TPE_0612 ENOG4105CIA precorrin-4 C(11)-methyltransferase TPE_0613 ENOG4108P62 biosynthesis protein (CbiG) TPE_0620 ENOG4109031 TPE_0621 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation TPE_0623 ENOG4105FDK ABC transporter TPE_0624 ENOG4105FAV ABC, transporter TPE_0630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TPE_0636 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TPE_0653 ENOG4105DIK (ABC) transporter TPE_0660 ENOG4105CGH 5'-nucleotidase TPE_0662 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) TPE_0663 ENOG4107QP8 phosphohexose isomerase TPE_0664 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) TPE_0666 ENOG4105CEY Amp-dependent synthetase and ligase TPE_0672 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) TPE_0674 ENOG4105CH2 amidohydrolase TPE_0678 ENOG4108IUW ABC transporter TPE_0688 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) TPE_0695 ENOG4105BZ1 (ABC) transporter TPE_0696 ENOG4105BZ1 (ABC) transporter TPE_0698 ENOG4108JJB ABC transporter TPE_0700 ENOG4108R6W Transcriptional regulator, ARAC family TPE_0707 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) TPE_0713 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase TPE_0716 ENOG4105CJW magnesium transporter TPE_0721 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TPE_0725 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TPE_0727 ENOG4105CI2 imidazolone-5-propionate hydrolase TPE_0729 ENOG4105DAP Nicotinate phosphoribosyltransferase TPE_0731 ENOG4107MD5 glycoside hydrolase, family TPE_0732 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) TPE_0736 ENOG4105D17 glycoside hydrolase, family 3 domain protein TPE_0737 ENOG41062VP TPE_0739 ENOG4108UZE carboxy-peptidase TPE_0740 ENOG4105WN5 stage II sporulation protein TPE_0747 ENOG41080E8 Transcriptional regulator, Spx MgsR family TPE_0748 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) TPE_0750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TPE_0753 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 TPE_0760 ENOG4107QID Threonine synthase TPE_0762 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) TPE_0763 ENOG4105C0H protease TPE_0764 ENOG4105E0Y RtcB Protein TPE_0765 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) TPE_0766 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TPE_0767 ENOG4105DF9 Lipoate-protein, ligase TPE_0768 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) TPE_0769 ENOG4108KS2 transglutaminase domain protein TPE_0772 ENOG4105C8N cysteinyl-tRNA synthetase TPE_0775 ENOG4105TMB Formate nitrite transporter TPE_0776 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TPE_0777 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) TPE_0783 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) TPE_0785 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) TPE_0787 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) TPE_0790 ENOG4105CJ1 ABC, transporter TPE_0792 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TPE_0793 ENOG4105DR5 peptidase TPE_0795 ENOG4105XVJ Protein of unknown function (DUF327) TPE_0796 ENOG4105MA4 psp1 domain protein TPE_0799 ENOG4105D7X high-affinity nickel-transporter TPE_0801 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0803 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) TPE_0805 ENOG4105BZ1 (ABC) transporter TPE_0810 ENOG4105CXT aspartate transcarbamylase TPE_0811 ENOG4105CSM endonuclease III TPE_0812 ENOG4105CNU cell division protein FtsK TPE_0813 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TPE_0816 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) TPE_0817 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) TPE_0818 ENOG4105DFM M18 family aminopeptidase TPE_0820 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for TPE_0821 ENOG41090A1 ferritin TPE_0824 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TPE_0825 ENOG4105DWF phosphomethylpyrimidine kinase TPE_0826 ENOG4105C8M UPF0272 protein TPE_0827 ENOG4105CCS Glutamate formiminotransferase TPE_0828 ENOG4105CIH Imidazole acetol-phosphate transaminase TPE_0830 ENOG4105ZAM anti-sigma-28 factor flgm family protein TPE_0831 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) TPE_0832 ENOG4106TEA TPE_0833 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TPE_0834 ENOG4105CB5 ATP-dependent DNA helicase recG TPE_0837 ENOG4108JQ7 (ABC) transporter TPE_0839 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_0840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_0841 ENOG4105WYW fructose-bisphosphate aldolase TPE_0844 ENOG4105KRQ Addiction module toxin, Txe YoeB family TPE_0846 ENOG4105KRQ Addiction module toxin, Txe YoeB family TPE_0848 ENOG4105MBR gumn family TPE_0851 ENOG41067S9 phage shock protein C, PspC TPE_0852 ENOG4105MQ3 flagellar protein FliS TPE_0853 ENOG4106VWR TPE_0854 ENOG4105C0D helicase TPE_0855 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0858 ENOG4108IG5 Transcriptional regulator TPE_0861 ENOG4105BZ1 (ABC) transporter TPE_0864 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TPE_0866 ENOG4105E0A ABC, transporter TPE_0867 ENOG4105EHG Permease protein TPE_0869 ENOG4108I0C methyltransferase TPE_0881 ENOG4105BZ1 (ABC) transporter TPE_0884 ENOG41090KZ TPE_0888 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) TPE_0889 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TPE_0892 ENOG4108PJD permease TPE_0894 ENOG4105C0B DNA polymerase III (alpha subunit) TPE_0895 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr TPE_0896 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0898 ENOG4108IUW ABC transporter TPE_0902 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) TPE_0903 ENOG4105EJ9 Membrane TPE_0905 ENOG4108Z40 Transcriptional regulator TPE_0906 ENOG4108RYK Nad-dependent epimerase dehydratase TPE_0909 ENOG4106JH4 TPE_0910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TPE_0914 ENOG4105E0A ABC, transporter TPE_0916 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit TPE_0918 ENOG4107QIZ NADH dehydrogenase TPE_0919 ENOG4107QHI -hydrogenase TPE_0922 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TPE_0923 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TPE_0924 ENOG4108RMU ferritin dps family protein TPE_0925 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0930 ENOG4105VFE sira family TPE_0932 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) TPE_0935 ENOG4105DG7 nitrate ABC transporter TPE_0939 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase TPE_0942 ENOG4108SP1 single-stranded DNA-binding protein TPE_0943 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase TPE_0949 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_0950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_0951 ENOG4105C3U ABC transporter TPE_0952 ENOG4108JQ5 ABC transporter TPE_0953 ENOG4105BZ1 (ABC) transporter TPE_0954 ENOG4105BZ1 (ABC) transporter TPE_0960 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) TPE_0961 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) TPE_0962 ENOG4105DTN riboflavin biosynthesis protein ribF TPE_0963 ENOG4105C8Q Methyl-accepting chemotaxis TPE_0968 ENOG4105CUZ uba thif-type nad fad binding protein TPE_0969 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) TPE_0971 ENOG4105C2W permease TPE_0973 ENOG410841Q phosphoesterase PA-phosphatase related protein TPE_0974 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TPE_0975 ENOG41071ZZ TPE_0976 ENOG4105C3F Signal peptidase i TPE_0979 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) TPE_0983 ENOG4105F8J Adenylate Guanylate cyclase TPE_0984 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TPE_0985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TPE_0986 ENOG4108J59 Extracellular solute-binding protein, family 5 TPE_1020 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TPE_1022 ENOG4105CFP Peptidase U32 TPE_1023 ENOG4105DVM PP-loop domain protein TPE_1024 ENOG4105BZ1 (ABC) transporter TPE_1027 ENOG4105BZ1 (ABC) transporter TPE_1028 ENOG4105BZ1 (ABC) transporter TPE_1031 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase TPE_1032 ENOG4105FA0 parb-like partition protein TPE_1033 ENOG4107QJE Chromosome Partitioning Protein TPE_1035 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1039 ENOG4105DRR Transcriptional regulator, GntR family TPE_1041 ENOG4107QSA Oxaloacetate decarboxylase TPE_1043 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein TPE_1044 ENOG4105D9Q decarboxylase (Beta subunit) TPE_1046 ENOG4105CI0 Citrate lyase TPE_1047 ENOG4105CHY citrate lyase, alpha TPE_1052 ENOG4105D07 Signal peptide peptidase, SppA TPE_1053 ENOG4105C3G gtp-binding protein TPE_1057 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) TPE_1058 ENOG4108SSC basic membrane TPE_1060 ENOG4108TWB ABC transporter (Permease TPE_1061 ENOG4108ZV0 ABC transporter, permease TPE_1063 ENOG4107YT1 Glutamate mutase subunit sigma TPE_1070 ENOG4108IJ2 phosphate acetyltransferase TPE_1071 ENOG4107GWN repeat protein TPE_1072 ENOG4105DPN Oligoendopeptidase f TPE_1073 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TPE_1074 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) TPE_1076 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TPE_1077 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) TPE_1080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) TPE_1083 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase TPE_1085 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1087 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) TPE_1088 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TPE_1089 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TPE_1090 ENOG4105C87 Aminotransferase class I and II TPE_1093 ENOG4107Z9R response regulator TPE_1095 ENOG4105YFD chemotaxis, protein TPE_1096 ENOG4105CBS Chea signal transduction histidine kinase TPE_1099 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TPE_1102 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) TPE_1103 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TPE_1104 ENOG4106ARS TPE_1107 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein TPE_1113 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase TPE_1115 ENOG4108XHQ (2Fe-2S)-binding domain protein TPE_1118 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) TPE_1119 ENOG4105VS8 Flagellar biosynthetic protein fliq TPE_1120 ENOG4105D19 Role in flagellar biosynthesis (By similarity) TPE_1121 ENOG4105D00 flagellar biosynthetic protein flhB TPE_1122 ENOG4105D7B Flagellar biosynthesis protein flha TPE_1126 ENOG4105C59 p-type ATPase TPE_1128 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TPE_1132 ENOG4105DJV ribulose-phosphate 3-epimerase TPE_1134 ENOG41063VX Inherit from COG: glutaredoxin-related protein TPE_1139 ENOG4105DR5 peptidase TPE_1140 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) TPE_1144 ENOG4105DF5 DNA topoisomerase IV, subunit A TPE_1145 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TPE_1147 ENOG4105E0A ABC, transporter TPE_1162 ENOG4105E0A ABC, transporter TPE_1163 ENOG4108JTQ reductase TPE_1164 ENOG4105E4R Precorrin-3B C17-methyltransferase TPE_1165 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1166 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) TPE_1167 ENOG4105DVK Precorrin-2 c20-methyltransferase TPE_1168 ENOG4107PPM cobalt chelatase TPE_1170 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1171 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) TPE_1172 ENOG4105D6A Electron transport complex TPE_1173 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit TPE_1174 ENOG4105DZB Electron transport complex TPE_1175 ENOG4105DGN Electron transport complex TPE_1179 ENOG41082I4 UPF0102 protein TPE_1180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TPE_1181 ENOG4105D00 flagellar biosynthetic protein flhB TPE_1183 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TPE_1184 ENOG4105VVB TPE_1185 ENOG4108JYZ YitT family TPE_1187 ENOG4105EI2 Pseudouridine synthase TPE_1188 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) TPE_1189 ENOG4105C26 Dehydrogenase TPE_1190 ENOG4105DFD Na H antiporter TPE_1191 ENOG4105DJI Methylaspartate mutase, E subunit TPE_1195 ENOG41062BZ domain protein TPE_1197 ENOG4105F8J Adenylate Guanylate cyclase TPE_1199 ENOG4107RFY SbcCD D subunit TPE_1200 ENOG4105EYH Exonuclease TPE_1202 ENOG4105T73 TPE_1204 ENOG4105X1A TPE_1205 ENOG41062Z1 TPE_1215 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TPE_1216 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TPE_1220 ENOG4105IJJ transcriptional regulator, crp fnr family TPE_1228 ENOG41080XV Thioredoxin TPE_1229 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination TPE_1230 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination TPE_1231 ENOG4108UT2 hemolysin iii TPE_1233 ENOG4108YZY peptidylprolyl cis-trans isomerase TPE_1241 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase TPE_1242 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TPE_1244 ENOG4105EAH synthase TPE_1245 ENOG4107QR9 Iron-sulfur cluster binding protein TPE_1250 ENOG4105D0U Arsenite-activated ATPase (ArsA) TPE_1252 ENOG4105BZJ Electron transfer flavoprotein TPE_1253 ENOG4105C10 Electron transfer flavoprotein TPE_1282 ENOG4105VXP Protein of unknown function DUF86 TPE_1301 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TPE_1327 ENOG4105D3A purine nucleoside phosphorylase DeoD-type TPE_1362 ENOG41064HX Suppressor of fused protein (SUFU) TPE_1370 ENOG4105BZ1 (ABC) transporter TPE_1382 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1390 ENOG4108R6W Transcriptional regulator, ARAC family TPE_1391 ENOG4105BZ1 (ABC) transporter TPE_1392 ENOG4105BZ1 (ABC) transporter TPE_1403 ENOG4105HMI Membrane TPE_1405 ENOG4108JJB ABC transporter TPE_1408 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1410 ENOG4105GSQ TM1410 hypothetical-related protein TPE_1411 ENOG4107TFB basic membrane TPE_1412 ENOG4108JQ9 ABC transporter TPE_1413 ENOG4105UIB (ABC) transporter TPE_1415 ENOG4106R77 TPE_1417 ENOG4105BZA Phosphoglycerate kinase TPE_1419 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase TPE_1421 ENOG4107NGC Flagellar filament outer layer protein TPE_1423 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) TPE_1424 ENOG41083IJ DNA-binding protein TPE_1425 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) TPE_1429 ENOG4105CEM UPF0597 protein TPE_1430 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TPE_1431 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate TPE_1433 ENOG4107QN2 dihydrolipoyl dehydrogenase TPE_1434 ENOG4106XCQ Inherit from COG: Pfam:DUF82 TPE_1435 ENOG4105BZ1 (ABC) transporter TPE_1436 ENOG4105BZ1 (ABC) transporter TPE_1440 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) TPE_1442 ENOG4106W1H TPE_1444 ENOG4105K9Q Binds to the 23S rRNA (By similarity) TPE_1445 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) TPE_1446 ENOG4105Z8H single-stranded DNA-binding protein TPE_1447 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) TPE_1448 ENOG4105CNA YD repeat protein TPE_1450 ENOG4105CNA YD repeat protein TPE_1454 ENOG4105C7N Xanthine uracil vitamin C permease TPE_1457 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) TPE_1459 ENOG4105F1A Pyruvate formate-lyase TPE_1460 ENOG4105VN1 Heat shock protein TPE_1461 ENOG4105HCZ TPE_1465 ENOG4105BZ1 (ABC) transporter TPE_1466 ENOG4105BZ1 (ABC) transporter TPE_1467 ENOG4105E0A ABC, transporter TPE_1468 ENOG4105EHG Permease protein TPE_1469 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) TPE_1471 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1473 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) TPE_1474 ENOG4105BZU Histidine kinase TPE_1477 ENOG4108IUZ ABC transporter TPE_1478 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) TPE_1481 ENOG4105CIN aminoacyl-histidine dipeptidase TPE_1482 ENOG4105CUT histidyl-tRNA synthetase TPE_1484 ENOG4107ZET Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) TPE_1485 ENOG4108YZT Adenosylcobinamide kinase TPE_1486 ENOG4105C98 muts2 protein TPE_1488 ENOG4106UUF TPE_1495 ENOG4105WN5 stage II sporulation protein TPE_1499 ENOG4105C0F tryptophanase EC 4.1.99.1 TPE_1500 ENOG4105D5T phosphonate abc transporter TPE_1502 ENOG4105S7S phosphonate abc transporter TPE_1503 ENOG4108RY1 ATP synthase, subunit E TPE_1508 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TPE_1509 ENOG4105D7A ATP-binding protein TPE_1510 ENOG4105C0F tryptophanase EC 4.1.99.1 TPE_1511 ENOG4108JQ7 (ABC) transporter TPE_1513 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_1514 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_1515 ENOG4105DEF Extracellular solute-binding protein, family 5 TPE_1516 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1522 ENOG4107RBS Methyltransferase TPE_1523 ENOG4107WUB V-type ATPase 116 kDa subunit TPE_1526 ENOG4105DM4 PTS System TPE_1527 ENOG4106447 Preprotein translocase subunit SecG TPE_1529 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TPE_1530 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TPE_1532 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) TPE_1533 ENOG4105K4W Could be involved in septation (By similarity) TPE_1534 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) TPE_1536 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TPE_1538 ENOG4108RAC Rubrerythrin TPE_1544 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TPE_1545 ENOG4105HHA aminodeoxychorismate lyase TPE_1547 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) TPE_1553 ENOG4105C3K feS assembly ATPase SufC TPE_1554 ENOG4105DIW FeS assembly protein SUFB TPE_1556 ENOG4105DUM transcriptional regulator, lysR family TPE_1557 ENOG4105CJ1 ABC, transporter TPE_1560 ENOG4105C8T Leucyl-tRNA synthetase TPE_1567 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TPE_1569 ENOG4106GEY TPE_1646 ENOG4105CSA Coproporphyrinogen iii oxidase TPE_1649 ENOG4105EHG Permease protein TPE_1651 ENOG4105DC7 peptidase M24 TPE_1652 ENOG4105C12 Phosphoribosylglycinamide synthetase TPE_1653 ENOG4105CPF Cell wall formation (By similarity) TPE_1655 ENOG4108ENG carbohydrate kinase, YjeF related protein TPE_1656 ENOG4108Z4J Cytidine monophosphate kinase TPE_1657 ENOG4105DSJ YicC domain protein TPE_1658 ENOG4105DFU Cell wall formation (By similarity) TPE_1659 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase TPE_1662 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) TPE_1663 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN TPE_1665 ENOG4105DSE periplasmic solute binding protein TPE_1666 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) TPE_1667 ENOG4105EEI dihydropteroate synthase TPE_1668 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TPE_1669 ENOG4105E4C Lytic transglycosylase catalytic TPE_1671 ENOG4105JVQ RNA Polymerase TPE_1674 ENOG41080VC Galactokinase (EC 2.7.1.6) TPE_1675 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) TPE_1677 ENOG4105DXN mazG family TPE_1680 ENOG4105CN1 protease TPE_1682 ENOG4107QI1 Mate efflux family protein TPE_1686 ENOG4105C5B carbamate kinase TPE_1688 ENOG4105MB2 TPE_1690 ENOG4105DVT helicase TPE_1734 ENOG4105CY0 Metallo-Beta-Lactamase TPE_1735 ENOG4106SWD TPE_1736 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TPE_1738 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) TPE_1741 ENOG4105C5H ABC transporter TPE_1743 ENOG4105CTM Glycoside hydrolase family 5 TPE_1746 ENOG4105C5I Dehydrogenase TPE_1747 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) TPE_1751 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TPE_1752 ENOG4105C2M dna polymerase I TPE_1754 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) TPE_1755 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) TPE_1760 ENOG4108N5C SNARE associated Golgi protein-related protein TPE_1762 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) TPE_1764 ENOG4105D8X mechanosensitive ion channel TPE_1769 ENOG4107RM6 sulfurtransferase TPE_1773 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) TPE_1778 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TPE_1780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TPE_1781 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TPE_1785 ENOG4105DFF Rod shape-determining protein mreb TPE_1788 ENOG4105CJN penicillin-binding protein TPE_1789 ENOG4105CNI cell division protein FtsW TPE_1793 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) TPE_1794 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1796 ENOG4107U1W v-type ATP synthase subunit I TPE_1797 ENOG4108WBK V-type ATP synthase subunit D TPE_1798 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit TPE_1799 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) TPE_1800 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TPE_1803 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TPE_1806 ENOG4108IUW ABC transporter TPE_1811 ENOG4105CDY transcriptional regulatory protein TPE_1813 ENOG4105DC1 bifunctional purine biosynthesis protein purh TPE_1815 ENOG4105DFM M18 family aminopeptidase TPE_1820 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) TPE_1822 ENOG4105BZG amino acid carrier protein TPE_1826 ENOG4107ZFZ Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) TPE_1827 ENOG4105CAH Chromate TPE_1830 ENOG4105CTJ Metal Dependent Phosphohydrolase TPE_1831 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) TPE_1832 ENOG4105C37 (CBS) domain TPE_1833 ENOG4107QKZ Ompa motb domain protein TPE_1834 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) TPE_1841 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) TPE_1845 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) TPE_1847 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor TPE_1849 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) TPE_1850 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) TPE_1855 ENOG4106QD2 TPE_1856 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) TPE_1858 ENOG4105CSA Coproporphyrinogen iii oxidase TPE_1860 ENOG4105VCQ rubredoxin TPE_1862 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) TPE_1864 ENOG4105D48 metallophosphoesterase TPE_1866 ENOG4105EAH synthase TPE_1869 ENOG4108IUW ABC transporter TPE_1876 ENOG4105BZG amino acid carrier protein TPE_1878 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TPE_1880 ENOG41084YP 30S ribosomal protein S21 TPE_1881 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) TPE_1884 ENOG4107V28 uracil phosphoribosyltransferase TPE_1885 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TPE_1886 ENOG4108R3D Electron transport complex TPE_1887 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) TPE_1889 ENOG4105DER m42 family TPE_1890 ENOG4105C6K Malic enzyme TPE_1894 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TPE_1895 ENOG4105D3G Pseudouridine synthase TPE_1896 ENOG4105DR4 Methyltransferase TPE_1897 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) TPE_1898 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TPE_1899 ENOG4105ZFX TPE_1901 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs TPE_1902 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TPE_1906 ENOG4105C0H protease TPE_1907 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TPE_1908 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) TPE_1909 ENOG4108VJ1 Transcriptional regulator (CarD family TPE_1912 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TPE_1914 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TPE_1916 ENOG4107UIY sua5 ycio yrdc ywlc family protein TPE_1918 ENOG410698I TPE_1920 ENOG4105BZU Histidine kinase TPE_1922 ENOG4105W0I repeat-containing protein TPE_1923 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TPE_1924 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) TPE_1928 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TPE_1932 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TPE_1936 ENOG4106678 morphogenetic protein associated with SpoVID TPE_1937 ENOG4105DFD Na H antiporter TPE_1938 ENOG4105C28 cystathionine TPE_1942 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) TPE_1944 ENOG4105C5H ABC transporter TPE_1945 ENOG4105CS2 ec 3.2.1.21 TPE_1946 ENOG4107RBJ symporter TPE_1954 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) TPE_1956 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TPE_1957 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TPE_1959 ENOG4105DK7 lysyl-tRNA synthetase TPE_1960 ENOG4105CIH Imidazole acetol-phosphate transaminase TPE_1962 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) TPE_1963 ENOG4107QW4 alcohol dehydrogenase TPE_1964 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TPE_1965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TPE_1967 ENOG4108Z0C Uvrb UvrC protein TPE_1969 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TPE_1970 ENOG4105D60 lipoprotein releasing system transmembrane protein TPE_1972 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TPE_1975 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TPE_1979 ENOG4105C8Q Methyl-accepting chemotaxis TPE_1980 ENOG4107ZT5 Thiol disulfide interchange protein TPE_1981 ENOG4105C4R Atp-dependent dna helicase TPE_1984 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) TPE_1985 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase TPE_1987 ENOG4105D3Y Na H antiporter TPE_1989 ENOG4106YRG TPE_1991 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TPE_1993 ENOG4105BZ1 (ABC) transporter TPE_1994 ENOG4108JJB ABC transporter TPE_1997 ENOG4105C5H ABC transporter TPE_1998 ENOG4105I76 (LipO)protein TPE_1999 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) TPE_2002 ENOG4108JQ7 (ABC) transporter TPE_2004 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_2007 ENOG4105D1U peptidase U62 modulator of DNA gyrase TPE_2012 ENOG4106SUR Protein of unknown function DUF115 TPE_2013 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TPE_2015 ENOG4105CFG Acts as a chaperone (By similarity) TPE_2016 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TPE_2017 ENOG4105SKN orotidine 5''-phosphate decarboxylase TPE_2019 ENOG4105E2X shikimate dehydrogenase TPE_2020 ENOG4105E66 phosphoriboisomerase A TPE_2022 ENOG4105CV1 Transketolase (EC 2.2.1.1) TPE_2024 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) TPE_2025 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) TPE_2026 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TPE_2027 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein TPE_2028 ENOG4105RKW reductase (By TPE_2029 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TPE_2030 ENOG4105CHR reductase TPE_2031 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TPE_2032 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TPE_2034 ENOG4105C9M aspartyl-trna synthetase TPE_2037 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TPE_2039 ENOG4105EPW hflc protein TPE_2040 ENOG4107RIZ hflk protein TPE_2042 ENOG4105DUA (citrate (pro-3S)-lyase ligase TPE_2043 ENOG4107GFK fumarate TPE_2044 ENOG4106DSS Tartrate dehydratase subunit alpha TPE_2046 ENOG4105I03 Flagellin TPE_2047 ENOG4105YFD chemotaxis, protein TPE_2049 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TPE_2050 ENOG4105BZ1 (ABC) transporter TPE_2051 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TPE_2052 ENOG4105C84 Histidine ammonia-lyase TPE_2054 ENOG4105CJ1 ABC, transporter TPE_2057 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) TPE_2086 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) TPE_2088 ENOG4108JQ7 (ABC) transporter TPE_2090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_2091 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_2092 ENOG4105DIB Oligopeptide-binding protein TPE_2094 ENOG4105F23 Fibronectin-binding protein TPE_2095 ENOG410877G TPE_2096 ENOG4105RJI TPE_2097 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) TPE_2098 ENOG4108UIC UPF0340 protein TPE_2101 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) TPE_2104 ENOG4108JIR Flagellum-specific ATP synthase TPE_2105 ENOG4105W2B Flagellar assembly protein TPE_2106 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TPE_2107 ENOG4107U2N Flagellar M-ring protein TPE_2108 ENOG41069WH flagellar hook-basal body complex TPE_2109 ENOG4108ZC9 flagellar basal-body rod protein flgc TPE_2110 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TPE_2111 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) TPE_2112 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) TPE_2113 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TPE_2114 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TPE_2118 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TPE_2119 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TPE_2121 ENOG4105CNI cell division protein FtsW TPE_2122 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TPE_2124 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) TPE_2125 ENOG4107YM1 mraZ protein TPE_2127 ENOG4105D82 Glutamate dehydrogenase TPE_2129 ENOG41086CX Inherit from COG: 40-residue yvtn family beta-propeller repeat protein TPE_2131 ENOG4105C1J atp-dependent rna helicase TPE_2133 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family TPE_2134 ENOG4105EZ5 reductase TPE_2135 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TPE_2139 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TPE_2140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_2141 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_2144 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TPE_2145 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase TPE_2147 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) TPE_2149 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2150 ENOG4105DZP Membrane-associated zinc metalloprotease TPE_2151 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TPE_2153 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TPE_2154 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) TPE_2155 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) TPE_2156 ENOG4105CE9 30S ribosomal protein S2 TPE_2173 ENOG4105CNA YD repeat protein TPE_2184 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2187 ENOG4105D1U peptidase U62 modulator of DNA gyrase TPE_2188 ENOG4105CMS peptidase U62, modulator of DNA gyrase TPE_2189 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) TPE_2191 ENOG4105CHY citrate lyase, alpha TPE_2192 ENOG4105EM7 Selenocysteine-specific translation elongation factor TPE_2194 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) TPE_2195 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TPE_2196 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TPE_2197 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) TPE_2199 ENOG4105C8B TIGR00159 family TPE_2200 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) TPE_2201 ENOG4105C0H protease TPE_2202 ENOG4108Z03 MAF-like protein TPE_2203 ENOG4105SXG TPE_2204 ENOG4105ZF0 Lipoprotein TPE_2205 ENOG4105I03 Flagellin TPE_2206 ENOG4105I03 Flagellin TPE_2207 ENOG41083S7 flagellar protein FlaG TPE_2208 ENOG4107VE5 flagellar hook-associated protein TPE_2209 ENOG4106SAP TPE_2211 ENOG4105K8N protein family UPF0079, ATPase TPE_2213 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TPE_2215 ENOG4108JDX DNA polymerase iii, epsilon subunit TPE_2216 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TPE_2219 ENOG410684W TPE_2225 ENOG4106D63 TPE_2227 ENOG4108ZVA radical SAM domain protein TPE_2230 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TPE_2231 ENOG4108JQC penicillin-binding protein 1A TPE_2232 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) TPE_2233 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) TPE_2237 ENOG4107EFR Flavocytochrome c TPE_2244 ENOG4105C0P Mg chelatase subunit ChlI TPE_2246 ENOG4105CFC Transporter TPE_2247 ENOG4106B9X TPE_2248 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) TPE_2252 ENOG4105C3M thioredoxin reductase TPE_2254 ENOG4105CGA flagellar basal-body rod protein FlgG TPE_2255 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) TPE_2258 ENOG4105M7K Involved in the transcription termination process (By similarity) TPE_2259 ENOG4107Z25 Basic membrane protein TPE_2260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TPE_2266 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TPE_2268 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TPE_2275 ENOG4108V3E phosphoribosylglycinamide formyltransferase TPE_2285 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TPE_2288 ENOG4105BZU Histidine kinase TPE_2290 ENOG4105Y6R TPE_2293 ENOG4108HU6 Metal dependent phosphohydrolase TPE_2295 ENOG4105IJJ transcriptional regulator, crp fnr family TPE_2296 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) TPE_2297 ENOG4105CJ2 (LipO)protein TPE_2298 ENOG4107SCN K03215 23S rRNA (uracil1939-C5)-methyltransferase EC 2.1.1.190 TPE_2308 ENOG4105BZ8 glutamate synthase TPE_2309 ENOG4107QHI -hydrogenase TPE_2310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TPE_2311 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) TPE_2312 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) TPE_2314 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TPE_2316 ENOG41068FD TPE_2318 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) TPE_2320 ENOG41085BT Protein of unknown function (DUF1312) TPE_2321 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TPE_2322 ENOG4105CFP Peptidase U32 TPE_2324 ENOG4105BZ1 (ABC) transporter TPE_2330 ENOG4108JJB ABC transporter TPE_2333 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TPE_2334 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TPE_2337 ENOG41089XN TPE_2344 ENOG4105CJ1 ABC, transporter TPE_2345 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TPE_2346 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TPE_2347 ENOG4105VIE preprotein translocase, subunit YajC TPE_2348 ENOG41085YX 50S ribosomal protein L32 TPE_2349 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) TPE_2350 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) TPE_2351 ENOG4105C25 Primosomal protein n' TPE_2352 ENOG4108UN4 phage SPO1 DNA polymerase-related protein TPE_2353 ENOG41061XC TPE_2354 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TPE_2355 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) TPE_2359 ENOG4105DR5 peptidase TPE_2361 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2366 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TPE_2367 ENOG41082DI 50s ribosomal protein l31 TPE_2370 ENOG4108IJ0 Aspartate ammonia-lyase TPE_2372 ENOG4108JA2 transcriptioN-repair coupling factor TPE_2376 ENOG4105C59 p-type ATPase TPE_2379 ENOG4105G3C Type iv pilus assembly TPE_2383 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TPE_2384 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) TPE_2385 ENOG4105DBV ornithine carbamoyltransferase TPE_2387 ENOG4105W5Q DNA repair protein (RadC TPE_2389 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TPE_2393 ENOG4105HEE Binding Domain protein TPE_2394 ENOG4105BZ1 (ABC) transporter TPE_2396 ENOG4108QUE repeat-containing protein TPE_2401 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TPE_2403 ENOG4108IG5 Transcriptional regulator TPE_2405 ENOG4105BZ1 (ABC) transporter TPE_2410 ENOG4105KY5 gCN5-related N-acetyltransferase TPE_2441 ENOG4105EI2 Pseudouridine synthase TPE_2444 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) TPE_2447 ENOG4106VF0 TPE_2453 ENOG4105D56 permease protein TPE_2454 ENOG4105EG2 ABC transporter, permease TPE_2456 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) TPE_2460 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) TPE_2461 ENOG4105CHV Transcription elongation factor NusA TPE_2462 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) TPE_2463 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) TPE_2464 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TPE_2467 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) TPE_2468 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) TPE_2469 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) TPE_2470 ENOG4105K4H Nlp p60 protein TPE_2471 ENOG4105CEY Amp-dependent synthetase and ligase TPE_2480 ENOG4105C2J ABC transporter TPE_2481 ENOG4105K95 (LipO)protein TPE_2486 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 TPE_2487 ENOG4105C12 Phosphoribosylglycinamide synthetase TPE_2488 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) TPE_2489 ENOG4105E1F short-chain dehydrogenase reductase TPE_2490 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase TPE_2495 ENOG4108V0P LemA family TPE_2497 ENOG4105C8V SAICAR synthetase TPE_2498 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TPE_2499 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) TPE_2500 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TPE_2503 ENOG4106RHC TPE_2505 ENOG4106XHX TPE_2506 ENOG4105UYK outer membrane protein a TPE_2507 ENOG4105K4H Nlp p60 protein TPE_2510 ENOG4108JQ7 (ABC) transporter TPE_2512 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_2513 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_2517 ENOG4108J59 Extracellular solute-binding protein, family 5 TPE_2518 ENOG4105G9E TPE_2519 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) TPE_2522 ENOG41090QR TPE_2523 ENOG4105DJ0 Poly(A) Polymerase TPE_2524 ENOG4106FRC TPE_2525 ENOG4105JTB TPE_2528 ENOG4105DCI Phosphohydrolase TPE_2530 ENOG4108DGI Phosphoribosylformylglycinamidine synthase I TPE_2533 ENOG4107ZYR domain protein TPE_2537 ENOG4106KG8 TPE_2538 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TPE_2539 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) TPE_2540 ENOG4105K6T rare lipoprotein A TPE_2541 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TPE_2542 ENOG41084MZ 50S ribosomal protein L35 TPE_2543 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) TPE_2544 ENOG4106BH8 TPE_2545 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) TPE_2546 ENOG41082MQ UPF0178 protein TPE_2549 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) TPE_2550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TPE_2551 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TPE_2552 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TPE_2557 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2558 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2563 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) TPE_2564 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) TPE_2565 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) TPE_2566 ENOG4105VB6 UPF0109 protein TPE_2567 ENOG4105K5M 30s ribosomal protein S16 TPE_2568 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TPE_2570 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) TPE_2572 ENOG4105YA8 Transcriptional regulator TPE_2574 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) TPE_2575 ENOG4105KT7 mgtC SapB transporter TPE_2578 ENOG4105CJ1 ABC, transporter TPE_2579 ENOG4108JQB penicillin-binding protein 1C TPE_2580 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) TPE_2581 ENOG4105F8V Hydrolase, tatD family TPE_2583 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) TPE_2584 ENOG4105DN3 alpha-2-macroglobulin domain protein TPE_2586 ENOG4107JR8 Colicin v production protein TPE_2587 ENOG4107QRG dna polymerase iii TPE_2588 ENOG4105BZU Histidine kinase TPE_2589 ENOG4105D3R alkyl hydroperoxide reductase TPE_2590 ENOG4105CGK Exodeoxyribonuclease III TPE_2591 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TPE_2592 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) TPE_2597 ENOG4105X4X Protein of unknown function DUF115 TPE_2598 ENOG41090QV Protein of unknown function DUF115 TPE_2605 ENOG4107R2W ABC transporter, permease TPE_2606 ENOG41084P6 50S ribosomal protein l28 TPE_2612 ENOG4105EHG Permease protein TPE_2614 ENOG4105BZ1 (ABC) transporter TPE_2618 ENOG4105BZ1 (ABC) transporter TPE_2619 ENOG4106DC9 TPE_2620 ENOG4108ZT0 50S ribosomal protein l17 TPE_2621 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TPE_2622 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) TPE_2623 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits TPE_2625 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TPE_2626 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) TPE_2627 ENOG41084HK 50S ribosomal protein L30 TPE_2628 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) TPE_2629 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) TPE_2630 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TPE_2631 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) TPE_2632 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits TPE_2633 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) TPE_2634 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) TPE_2635 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal TPE_2636 ENOG41086S0 50s ribosomal protein l29 TPE_2637 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) TPE_2638 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) TPE_2640 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity TPE_2641 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) TPE_2642 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) TPE_2643 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) TPE_2644 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) TPE_2645 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) TPE_2647 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TPE_2648 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) TPE_2656 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TPE_2659 ENOG4105C8Q Methyl-accepting chemotaxis TPE_2667 ENOG4105CB5 ATP-dependent DNA helicase recG TPE_2673 ENOG4105C5H ABC transporter TPE_2679 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TPE_2688 ENOG4105D29 Helix-turn-helix type 11 domain protein TPE_2693 ENOG41086D8 Transcriptional regulator TPE_2699 ENOG4107EFR Flavocytochrome c TPE_2701 ENOG4105E0A ABC, transporter TPE_2702 ENOG4105EHG Permease protein TPE_2703 ENOG4105DQ5 transport system permease protein TPE_2704 ENOG4108V5C ABC transporter TPE_2708 ENOG4105CGP Urocanate hydratase TPE_2714 ENOG4105DAN ATP-dependent protease TPE_2717 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase TPE_2718 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase TPE_2720 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) TPE_2721 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) TPE_2722 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) TPE_2723 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii TPE_2727 ENOG4105CP7 Triose-phosphate isomerase TPE_2728 ENOG4105CMR udp-glucose 4-epimerase TPE_2729 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP TPE_2731 ENOG4107QJQ Mate efflux family protein TPE_2732 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) TPE_2733 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TPE_2734 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TPE_2737 ENOG4108120 Pasta domain protein TPE_2738 ENOG4106S0F TPE_2739 ENOG4105CDU Replicative dna helicase TPE_2742 ENOG4105C98 muts2 protein TPE_2745 ENOG4107QVM von Willebrand factor, type A TPE_2750 ENOG4108M1M outer membrane lipoprotein-sorting protein TPE_2752 ENOG410630P Transcriptional regulator TPE_2754 ENOG4107RBD ABC, transporter TPE_2755 ENOG4107RPQ ABC transporter TPE_2756 ENOG4105DIK (ABC) transporter TPE_2757 ENOG4107SIG periplasmic solute binding protein TPE_2765 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TPE_2766 ENOG41081XE plasmid maintenance system antidote protein, xre family TPE_2769 ENOG4105CTQ phosphohexokinase TPE_2771 ENOG4105DNX Dna topoisomerase iv (Subunit b) TPE_2774 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) TPE_2776 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein TPE_2777 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TPE_2778 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) TPE_2779 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) TPE_2780 ENOG4105VG0 50S ribosomal protein l34 TPE_2781 ENOG4105DWD nucleoside recognition domain protein TPE_2782 ENOG4105D3A purine nucleoside phosphorylase DeoD-type TPE_2786 ENOG4105BZU Histidine kinase TPE_2787 ENOG4105BZU Histidine kinase TPE_2791 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) TPE_2792 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TPE_2793 ENOG4105CGA flagellar basal-body rod protein FlgG TPE_2794 ENOG410680E Flagellar protein TPE_2795 ENOG4107QWW Cell wall formation (By similarity) TPE_2805 ENOG4108VEN abc transporter atp-binding protein TPE_2806 ENOG4105C9U ATP-dependent DNA helicase RecQ TPE_2808 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)