locus-tag	class	description
TPE_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPE_0003	COG2235	arginine
TPE_0005	COG0017	Asparaginyl-tRNA synthetase
TPE_0006	COG1686	Belongs to the peptidase S11 family
TPE_0009	COG0840	transmembrane signaling receptor activity
TPE_0014	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TPE_0021	COG0728	peptidoglycan biosynthetic process
TPE_0022	COG0786	glutamate:sodium symporter activity
TPE_0027	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPE_0033	COG2885	chlorophyll binding
TPE_0034	COG0840	transmembrane signaling receptor activity
TPE_0035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPE_0037	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPE_0038	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TPE_0041	COG0574	Belongs to the PEP-utilizing enzyme family
TPE_0041	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_0044	COG2304	oxidoreductase activity
TPE_0046	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPE_0049	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_0050	COG1120	ATPase activity
TPE_0059	COG4750	Nucleotidyl transferase
TPE_0064	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPE_0066	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_0068	COG0588	phosphoglycerate mutase activity
TPE_0071	COG2033	superoxide reductase activity
TPE_0073	COG0534	Mate efflux family protein
TPE_0133	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_0134	COG0601	transmembrane transport
TPE_0135	COG0747	negative chemotaxis
TPE_0136	COG1917	Cupin 2, conserved barrel domain protein
TPE_0136	COG4977	sequence-specific DNA binding
TPE_0137	COG0840	transmembrane signaling receptor activity
TPE_0146	COG0455	bacterial-type flagellum organization
TPE_0148	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPE_0149	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPE_0149	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPE_0154	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPE_0158	COG3949	Membrane
TPE_0162	COG0840	transmembrane signaling receptor activity
TPE_0163	COG0542	response to heat
TPE_0164	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TPE_0168	COG0768	penicillin binding
TPE_0170	COG2604	Protein of unknown function DUF115
TPE_0173	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPE_0174	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPE_0176	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_0177	COG0037	tRNA processing
TPE_0178	COG0457	Tetratricopeptide repeat
TPE_0180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_0182	COG1073	alpha beta
TPE_0187	COG1373	ATPase (AAA superfamily
TPE_0190	COG1086	Polysaccharide biosynthesis protein
TPE_0191	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPE_0195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TPE_0196	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPE_0201	COG2089	acid synthase
TPE_0202	COG1083	cytidylyl-transferase
TPE_0203	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPE_0211	COG3475	LICD family
TPE_0221	COG1760	l-serine dehydratase
TPE_0222	COG1760	l-serine dehydratase
TPE_0223	COG1114	Component of the transport system for branched-chain amino acids
TPE_0226	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_0241	COG1570	exodeoxyribonuclease VII activity
TPE_0244	COG1129	ABC transporter
TPE_0246	COG3493	citrate carrier protein
TPE_0247	COG1879	ABC-type sugar transport system periplasmic component
TPE_0248	COG1840	ABC-type Fe3 transport system, periplasmic component
TPE_0249	COG0438	transferase activity, transferring glycosyl groups
TPE_0250	COG3842	ATPase activity
TPE_0252	COG0148	phosphopyruvate hydratase activity
TPE_0254	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPE_0255	COG1116	anion transmembrane transporter activity
TPE_0264	COG0569	domain protein
TPE_0265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPE_0266	COG0504	CTP synthase activity
TPE_0268	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_0268	COG0574	Belongs to the PEP-utilizing enzyme family
TPE_0271	COG2137	regulation of response to DNA damage stimulus
TPE_0272	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TPE_0273	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPE_0277	COG0840	transmembrane signaling receptor activity
TPE_0298	COG3177	Filamentation induced by cAMP protein fic
TPE_0302	COG4208	sulfate ABC transporter
TPE_0306	COG0726	polysaccharide deacetylase
TPE_0308	COG1122	ATPase activity
TPE_0309	COG1268	BioY protein
TPE_0312	COG1652	LysM domain
TPE_0313	COG0517	IMP dehydrogenase activity
TPE_0313	COG0516	GMP reductase activity
TPE_0316	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TPE_0323	COG0569	domain protein
TPE_0324	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPE_0330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPE_0334	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPE_0338	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPE_0341	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TPE_0344	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPE_0346	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TPE_0353	COG2226	methyltransferase
TPE_0359	COG4555	ABC transporter
TPE_0363	COG1132	(ABC) transporter
TPE_0364	COG1132	(ABC) transporter
TPE_0366	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPE_0367	COG3876	Protein conserved in bacteria
TPE_0368	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TPE_0379	COG1918	ferrous iron import across plasma membrane
TPE_0379	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPE_0395	COG0737	Belongs to the 5'-nucleotidase family
TPE_0398	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TPE_0400	COG0632	four-way junction helicase activity
TPE_0401	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPE_0404	COG0519	Catalyzes the synthesis of GMP from XMP
TPE_0410	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TPE_0411	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPE_0414	COG0577	efflux transmembrane transporter activity
TPE_0414	COG1136	(ABC) transporter
TPE_0415	COG1136	(ABC) transporter
TPE_0415	COG0577	efflux transmembrane transporter activity
TPE_0417	COG2217	Heavy metal translocating P-type atpase
TPE_0419	COG0525	valine-tRNA ligase activity
TPE_0420	COG1132	(ABC) transporter
TPE_0423	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPE_0425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TPE_0427	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPE_0428	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPE_0429	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPE_0433	COG1924	4 iron, 4 sulfur cluster binding
TPE_0434	COG0840	transmembrane signaling receptor activity
TPE_0442	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPE_0443	COG0250	Participates in transcription elongation, termination and antitermination
TPE_0444	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPE_0445	COG0081	regulation of translation
TPE_0446	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPE_0447	COG0222	ribosome binding
TPE_0448	COG0085	RNA polymerase activity
TPE_0449	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPE_0453	COG0322	excinuclease ABC activity
TPE_0457	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPE_0461	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPE_0462	COG4585	Histidine kinase
TPE_0465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TPE_0467	COG1363	Peptidase, m42
TPE_0470	COG1022	Amp-dependent synthetase and ligase
TPE_0472	COG1309	transcriptional regulator
TPE_0473	COG0786	glutamate:sodium symporter activity
TPE_0474	COG1132	(ABC) transporter
TPE_0477	COG1129	ABC transporter
TPE_0478	COG1132	(ABC) transporter
TPE_0480	COG0072	phenylalanine-tRNA ligase activity
TPE_0481	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPE_0482	COG1394	ATPase activity, coupled to movement of substances
TPE_0485	COG1692	metallophosphoesterase
TPE_0488	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPE_0490	COG1104	cysteine desulfurase activity
TPE_0491	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TPE_0492	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPE_0493	COG4536	flavin adenine dinucleotide binding
TPE_0494	COG1253	flavin adenine dinucleotide binding
TPE_0496	COG4166	transmembrane transport
TPE_0497	COG4608	Belongs to the ABC transporter superfamily
TPE_0498	COG0444	Belongs to the ABC transporter superfamily
TPE_0499	COG4166	transmembrane transport
TPE_0500	COG0747	negative chemotaxis
TPE_0501	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_0502	COG4174	ABC transporter (Permease)
TPE_0509	COG0745	RESPONSE REGULATOR receiver
TPE_0509	COG3706	GGDEF domain
TPE_0510	COG2203	Gaf domain
TPE_0510	COG2199	diguanylate cyclase activity
TPE_0516	COG0800	Aldolase
TPE_0529	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPE_0532	COG0328	RNA-DNA hybrid ribonuclease activity
TPE_0533	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TPE_0534	COG0301	tRNA thio-modification
TPE_0536	COG1131	(ABC) transporter
TPE_0539	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TPE_0540	COG0326	Molecular chaperone. Has ATPase activity
TPE_0543	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_0544	COG1509	lysine 2,3-aminomutase activity
TPE_0547	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TPE_0554	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_0555	COG0840	transmembrane signaling receptor activity
TPE_0558	COG0084	hydrolase, TatD family'
TPE_0559	COG3116	cell division
TPE_0559	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPE_0563	COG0716	FMN binding
TPE_0567	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPE_0568	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPE_0569	COG1419	protein localization to endoplasmic reticulum
TPE_0570	COG0455	bacterial-type flagellum organization
TPE_0572	COG1191	sigma factor activity
TPE_0578	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPE_0579	COG0628	permease
TPE_0580	COG0363	glucosamine-6-phosphate deaminase activity
TPE_0582	COG3118	belongs to the thioredoxin family
TPE_0584	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPE_0586	COG0584	glycerophosphoryl diester phosphodiesterase
TPE_0587	COG1040	competence protein
TPE_0588	COG0018	arginyl-trna synthetase
TPE_0589	COG0714	Associated with various cellular activities
TPE_0598	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TPE_0599	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPE_0601	COG1338	Plays a role in the flagellum-specific transport system
TPE_0603	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPE_0603	COG1776	CheC inhibitor of MCP methylation
TPE_0604	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TPE_0605	COG1580	Controls the rotational direction of flagella during chemotaxis
TPE_0606	COG1360	Flagellar Motor Protein
TPE_0607	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TPE_0610	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TPE_0612	COG2875	Belongs to the precorrin methyltransferase family
TPE_0620	COG2887	Belongs to the helicase family. UvrD subfamily
TPE_0621	COG1074	ATP-dependent DNA helicase activity
TPE_0623	COG1121	(ABC) transporter
TPE_0624	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_0630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_0632	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPE_0632	COG1747	RNA polymerase binding
TPE_0636	COG0116	Belongs to the methyltransferase superfamily
TPE_0653	COG1121	(ABC) transporter
TPE_0660	COG0737	Belongs to the 5'-nucleotidase family
TPE_0662	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPE_0663	COG0166	Belongs to the GPI family
TPE_0664	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TPE_0666	COG0318	PFAM AMP-dependent synthetase and ligase
TPE_0672	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPE_0674	COG1473	amidohydrolase
TPE_0678	COG4555	ABC transporter
TPE_0688	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TPE_0695	COG1132	(ABC) transporter
TPE_0696	COG1132	(ABC) transporter
TPE_0698	COG1129	ABC transporter
TPE_0700	COG2207	Transcriptional regulator
TPE_0706	COG2357	RelA SpoT domain protein
TPE_0707	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TPE_0713	COG1755	Isoprenylcysteine carboxyl methyltransferase
TPE_0716	COG2239	Acts as a magnesium transporter
TPE_0721	COG0556	nucleotide-excision repair
TPE_0725	COG4946	Tricorn protease homolog
TPE_0725	COG1506	peptidase
TPE_0725	COG0823	Involved in the tonB-independent uptake of proteins
TPE_0727	COG1228	amidohydrolase
TPE_0729	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPE_0732	COG0423	glycine-tRNA ligase activity
TPE_0736	COG1472	Belongs to the glycosyl hydrolase 3 family
TPE_0739	COG1876	peptidase activity
TPE_0740	COG1366	Belongs to the anti-sigma-factor antagonist family
TPE_0747	COG1393	Belongs to the ArsC family
TPE_0748	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPE_0750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPE_0751	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TPE_0752	COG1115	amino acid carrier protein
TPE_0753	COG1254	Belongs to the acylphosphatase family
TPE_0759	COG1301	dicarboxylic acid transport
TPE_0760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPE_0762	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPE_0763	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_0764	COG1690	Belongs to the RtcB family
TPE_0765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPE_0766	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPE_0766	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPE_0767	COG0095	Lipoate-protein ligase
TPE_0768	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TPE_0769	COG1305	Transglutaminase-like
TPE_0772	COG0215	cysteine-tRNA ligase activity
TPE_0774	COG0330	HflC and HflK could
TPE_0775	COG2116	formate transmembrane transporter activity
TPE_0776	COG0592	DNA-directed DNA polymerase activity
TPE_0777	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPE_0783	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TPE_0785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TPE_0787	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TPE_0790	COG1131	(ABC) transporter
TPE_0792	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPE_0793	COG0739	heme binding
TPE_0795	COG1728	Protein conserved in bacteria
TPE_0796	COG1774	PSP1 C-terminal conserved region
TPE_0799	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
TPE_0801	COG0840	transmembrane signaling receptor activity
TPE_0803	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TPE_0803	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPE_0803	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TPE_0803	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPE_0805	COG1132	(ABC) transporter
TPE_0810	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TPE_0810	COG0540	Belongs to the ATCase OTCase family
TPE_0811	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPE_0812	COG1674	ftsk spoiiie
TPE_0813	COG1968	undecaprenyl-diphosphatase activity
TPE_0816	COG1492	cobalamin metabolic process
TPE_0817	COG0445	tRNA wobble uridine modification
TPE_0818	COG1362	aminopeptidase activity
TPE_0820	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TPE_0821	COG1528	Iron-storage protein
TPE_0822	COG1505	serine-type exopeptidase activity
TPE_0824	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TPE_0825	COG0351	phosphomethylpyrimidine kinase
TPE_0828	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPE_0831	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TPE_0833	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TPE_0834	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPE_0837	COG4608	Belongs to the ABC transporter superfamily
TPE_0838	COG0444	Belongs to the ABC transporter superfamily
TPE_0839	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_0840	COG0601	transmembrane transport
TPE_0841	COG3588	fructose-bisphosphate aldolase
TPE_0844	COG4115	mRNA cleavage
TPE_0846	COG4115	mRNA cleavage
TPE_0848	COG3735	TraB family
TPE_0851	COG1983	PspC domain protein
TPE_0852	COG1516	flagellar protein fliS
TPE_0854	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPE_0855	COG0840	transmembrane signaling receptor activity
TPE_0861	COG1132	(ABC) transporter
TPE_0864	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_0866	COG1120	ATPase activity
TPE_0867	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_0869	COG2226	methyltransferase
TPE_0881	COG1132	(ABC) transporter
TPE_0888	COG0167	dihydroorotate dehydrogenase activity
TPE_0889	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TPE_0892	COG0701	Predicted permease
TPE_0894	COG0587	DNA-directed DNA polymerase activity
TPE_0895	COG1028	Short-chain dehydrogenase reductase Sdr
TPE_0897	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPE_0898	COG4555	ABC transporter
TPE_0903	COG0730	response to heat
TPE_0905	COG1959	2 iron, 2 sulfur cluster binding
TPE_0906	COG2910	NAD(P)H-binding
TPE_0907	COG2089	acid synthase
TPE_0910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPE_0914	COG1120	ATPase activity
TPE_0922	COG1696	Membrane protein involved in D-alanine export
TPE_0923	COG3842	ATPase activity
TPE_0924	COG0783	Belongs to the Dps family
TPE_0925	COG0840	transmembrane signaling receptor activity
TPE_0930	COG0425	Belongs to the sulfur carrier protein TusA family
TPE_0932	COG0709	Synthesizes selenophosphate from selenide and ATP
TPE_0935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPE_0938	COG1136	(ABC) transporter
TPE_0939	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TPE_0942	COG0629	single-stranded DNA binding
TPE_0943	COG1691	(AIR) carboxylase
TPE_0949	COG0601	transmembrane transport
TPE_0951	COG0444	Belongs to the ABC transporter superfamily
TPE_0952	COG4172	Belongs to the ABC transporter superfamily
TPE_0953	COG1132	(ABC) transporter
TPE_0954	COG1132	(ABC) transporter
TPE_0960	COG1185	polyribonucleotide nucleotidyltransferase activity
TPE_0961	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPE_0962	COG0196	riboflavin kinase activity
TPE_0963	COG0840	transmembrane signaling receptor activity
TPE_0968	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TPE_0969	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPE_0971	COG2233	PERMEase
TPE_0973	COG0671	phosphoesterase, PA-phosphatase related
TPE_0974	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TPE_0979	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_0984	COG0546	phosphoglycolate phosphatase activity
TPE_0985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPE_0986	COG4166	transmembrane transport
TPE_1020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPE_1022	COG0826	peptidase U32
TPE_1023	COG1606	tRNA processing
TPE_1024	COG1132	(ABC) transporter
TPE_1027	COG1132	(ABC) transporter
TPE_1028	COG1132	(ABC) transporter
TPE_1032	COG1475	DNA binding
TPE_1033	COG1192	Involved in chromosome partitioning
TPE_1035	COG0840	transmembrane signaling receptor activity
TPE_1039	COG1802	Transcriptional regulator
TPE_1043	COG0511	ligase activity, forming carbon-carbon bonds
TPE_1044	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TPE_1046	COG2301	Belongs to the HpcH HpaI aldolase family
TPE_1047	COG3051	citrate lyase alpha subunit
TPE_1052	COG0616	signal peptide processing
TPE_1053	COG0012	GTP binding
TPE_1057	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPE_1058	COG1744	ABC transporter substrate-binding protein PnrA-like
TPE_1059	COG3845	ABC transporter
TPE_1060	COG4603	Belongs to the binding-protein-dependent transport system permease family
TPE_1061	COG1079	Belongs to the binding-protein-dependent transport system permease family
TPE_1063	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TPE_1070	COG0280	phosphate acetyltransferase
TPE_1071	COG0457	Tetratricopeptide repeat
TPE_1073	COG0542	response to heat
TPE_1074	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPE_1076	COG0101	tRNA pseudouridine synthase activity
TPE_1080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TPE_1083	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPE_1085	COG0840	transmembrane signaling receptor activity
TPE_1087	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TPE_1088	COG0740	serine-type endopeptidase activity
TPE_1089	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPE_1090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TPE_1091	COG2211	Major facilitator Superfamily
TPE_1093	COG2201	protein-glutamate methylesterase activity
TPE_1095	COG0835	chemotaxis
TPE_1096	COG2198	Histidine kinase
TPE_1096	COG0643	Histidine kinase
TPE_1099	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPE_1102	COG0316	Belongs to the HesB IscA family
TPE_1102	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TPE_1103	COG0756	dUTP diphosphatase activity
TPE_1104	COG3330	Domain of unknown function (DUF4912)
TPE_1107	COG0543	2 iron, 2 sulfur cluster binding
TPE_1113	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPE_1115	COG2080	2 iron, 2 sulfur cluster binding
TPE_1118	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPE_1119	COG1987	bacterial-type flagellum assembly
TPE_1120	COG1684	flagellar biosynthetic protein fliR
TPE_1121	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_1122	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_1126	COG2217	Heavy metal translocating P-type atpase
TPE_1132	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TPE_1134	COG4545	Glutaredoxin-related protein
TPE_1139	COG0739	heme binding
TPE_1140	COG1418	mRNA catabolic process
TPE_1147	COG1120	ATPase activity
TPE_1151	COG1132	(ABC) transporter
TPE_1162	COG1120	ATPase activity
TPE_1165	COG0840	transmembrane signaling receptor activity
TPE_1170	COG0840	transmembrane signaling receptor activity
TPE_1171	COG4656	Part of a membrane complex involved in electron transport
TPE_1172	COG4658	electron transport chain
TPE_1173	COG4659	FMN binding
TPE_1174	COG4660	Part of a membrane complex involved in electron transport
TPE_1175	COG4657	Part of a membrane complex involved in electron transport
TPE_1179	COG0792	nuclease activity
TPE_1181	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TPE_1183	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TPE_1185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TPE_1188	COG0357	Ribosomal RNA small subunit methyltransferase G
TPE_1189	COG1012	belongs to the aldehyde dehydrogenase family
TPE_1190	COG1757	Na H antiporter
TPE_1191	COG4865	methylaspartate mutase activity
TPE_1195	COG0724	RNA recognition motif
TPE_1198	COG0534	Mate efflux family protein
TPE_1199	COG0420	3'-5' exonuclease activity
TPE_1200	COG0419	ATPase involved in DNA repair
TPE_1206	COG1187	pseudouridine synthase activity
TPE_1215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPE_1216	COG0154	amidase activity
TPE_1220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPE_1223	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPE_1223	COG0426	domain, Protein
TPE_1228	COG3118	belongs to the thioredoxin family
TPE_1231	COG1272	protein, Hemolysin III
TPE_1233	COG1047	Peptidyl-prolyl cis-trans
TPE_1241	COG0644	oxidoreductase
TPE_1242	COG2226	methyltransferase
TPE_1244	COG0142	geranyltranstransferase activity
TPE_1250	COG0003	Pfam Anion-transporting ATPase
TPE_1251	COG1620	l-lactate permease
TPE_1253	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TPE_1282	COG2361	Protein of unknown function DUF86
TPE_1285	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TPE_1301	COG0588	phosphoglycerate mutase activity
TPE_1306	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPE_1310	COG3177	Filamentation induced by cAMP protein fic
TPE_1327	COG0813	purine-nucleoside phosphorylase activity
TPE_1370	COG1132	(ABC) transporter
TPE_1379	COG0656	L-ascorbic acid biosynthetic process
TPE_1382	COG0840	transmembrane signaling receptor activity
TPE_1390	COG2207	Transcriptional regulator
TPE_1391	COG1132	(ABC) transporter
TPE_1392	COG1132	(ABC) transporter
TPE_1403	COG2855	membrane
TPE_1405	COG1129	ABC transporter
TPE_1410	COG2342	PFAM TM1410 hypothetical-related protein
TPE_1411	COG1744	ABC transporter substrate-binding protein PnrA-like
TPE_1417	COG0126	phosphoglycerate kinase activity
TPE_1419	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPE_1423	COG0268	Binds directly to 16S ribosomal RNA
TPE_1425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPE_1427	COG1058	Belongs to the CinA family
TPE_1427	COG1546	Belongs to the CinA family
TPE_1429	COG3681	Belongs to the UPF0597 family
TPE_1430	COG0840	transmembrane signaling receptor activity
TPE_1431	COG0617	tRNA 3'-terminal CCA addition
TPE_1433	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TPE_1435	COG1132	(ABC) transporter
TPE_1436	COG1132	(ABC) transporter
TPE_1440	COG0343	queuine tRNA-ribosyltransferase activity
TPE_1444	COG0359	binds to the 23S rRNA
TPE_1445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPE_1446	COG0629	single-stranded DNA binding
TPE_1447	COG0360	Binds together with S18 to 16S ribosomal RNA
TPE_1448	COG3209	COG3209 Rhs family protein
TPE_1448	COG4104	PAAR repeat-containing protein
TPE_1450	COG3209	COG3209 Rhs family protein
TPE_1454	COG2252	PERMEase
TPE_1457	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TPE_1459	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TPE_1460	COG0071	Belongs to the small heat shock protein (HSP20) family
TPE_1461	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPE_1465	COG1132	(ABC) transporter
TPE_1466	COG1132	(ABC) transporter
TPE_1467	COG1120	ATPase activity
TPE_1468	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_1469	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_1471	COG0840	transmembrane signaling receptor activity
TPE_1473	COG2201	protein-glutamate methylesterase activity
TPE_1477	COG1137	ATPase activity
TPE_1478	COG3976	FMN-binding domain protein
TPE_1478	COG0431	NADPH-dependent FMN reductase
TPE_1478	COG1053	succinate dehydrogenase
TPE_1479	COG1418	mRNA catabolic process
TPE_1481	COG2195	Cleaves the N-terminal amino acid of tripeptides
TPE_1482	COG0124	histidyl-tRNA synthetase
TPE_1484	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TPE_1486	COG1193	negative regulation of DNA recombination
TPE_1488	COG3706	GGDEF domain
TPE_1495	COG1366	Belongs to the anti-sigma-factor antagonist family
TPE_1499	COG3033	Beta-eliminating lyase
TPE_1500	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TPE_1502	COG3639	organic phosphonate transmembrane transporter activity
TPE_1503	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TPE_1508	COG0019	diaminopimelate decarboxylase activity
TPE_1509	COG0433	COG0433 Predicted ATPase
TPE_1511	COG4608	Belongs to the ABC transporter superfamily
TPE_1512	COG0444	Belongs to the ABC transporter superfamily
TPE_1515	COG0747	negative chemotaxis
TPE_1516	COG0840	transmembrane signaling receptor activity
TPE_1523	COG1269	ATP hydrolysis coupled proton transport
TPE_1526	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPE_1526	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPE_1526	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPE_1527	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPE_1529	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TPE_1530	COG2890	protein-(glutamine-N5) methyltransferase activity
TPE_1532	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPE_1533	COG2088	sporulation resulting in formation of a cellular spore
TPE_1534	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TPE_1536	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_1538	COG1592	Rubrerythrin
TPE_1539	COG1283	sodium-dependent phosphate transmembrane transporter activity
TPE_1543	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TPE_1544	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TPE_1545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPE_1553	COG0396	ATPase activity
TPE_1554	COG0719	Fe-S assembly protein
TPE_1556	COG0583	DNA-binding transcription factor activity
TPE_1557	COG1131	(ABC) transporter
TPE_1560	COG0495	leucyl-tRNA aminoacylation
TPE_1567	COG1196	nuclear chromosome segregation
TPE_1569	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPE_1646	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPE_1649	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_1651	COG0006	proline dipeptidase activity
TPE_1653	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPE_1655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TPE_1655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TPE_1656	COG1102	Psort location Cytoplasmic, score
TPE_1657	COG1561	YicC-like family, N-terminal region
TPE_1658	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPE_1659	COG0285	dihydrofolate synthase activity
TPE_1662	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPE_1665	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPE_1667	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPE_1668	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TPE_1668	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TPE_1669	COG1196	nuclear chromosome segregation
TPE_1669	COG0739	heme binding
TPE_1669	COG0741	lytic transglycosylase activity
TPE_1671	COG1595	DNA-templated transcription, initiation
TPE_1674	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPE_1675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TPE_1676	COG1966	Carbon starvation protein
TPE_1677	COG3956	TIGRFAM MazG family protein
TPE_1680	COG0793	Belongs to the peptidase S41A family
TPE_1682	COG0534	Mate efflux family protein
TPE_1686	COG0549	Belongs to the carbamate kinase family
TPE_1688	COG0823	Involved in the tonB-independent uptake of proteins
TPE_1690	COG1199	ATP-dependent helicase activity
TPE_1734	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TPE_1736	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TPE_1738	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TPE_1741	COG0488	(ABC) transporter
TPE_1746	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPE_1747	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TPE_1748	COG0058	SHG alpha-glucan phosphorylase activity
TPE_1751	COG0237	dephospho-CoA kinase activity
TPE_1752	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPE_1752	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPE_1752	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPE_1754	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TPE_1755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPE_1760	COG0398	Pfam SNARE associated Golgi protein
TPE_1762	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPE_1764	COG0668	transmembrane transport
TPE_1769	COG2897	thiosulfate sulfurtransferase activity
TPE_1778	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPE_1778	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPE_1779	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPE_1780	COG0358	DNA primase activity
TPE_1781	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TPE_1785	COG1077	Cell shape determining protein MreB Mrl
TPE_1788	COG0768	penicillin binding
TPE_1789	COG0772	Belongs to the SEDS family
TPE_1793	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPE_1794	COG0840	transmembrane signaling receptor activity
TPE_1796	COG1269	ATP hydrolysis coupled proton transport
TPE_1797	COG1394	ATPase activity, coupled to movement of substances
TPE_1798	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPE_1799	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPE_1800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TPE_1803	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPE_1804	COG1794	racemase activity, acting on amino acids and derivatives
TPE_1806	COG4555	ABC transporter
TPE_1811	COG0217	transcriptional regulatory protein
TPE_1813	COG0138	bifunctional purine biosynthesis protein purh
TPE_1815	COG1362	aminopeptidase activity
TPE_1820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TPE_1822	COG1115	amino acid carrier protein
TPE_1826	COG0799	negative regulation of ribosome biogenesis
TPE_1827	COG2059	Chromate
TPE_1830	COG1480	7TM receptor with intracellular HD hydrolase
TPE_1831	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPE_1833	COG2885	chlorophyll binding
TPE_1834	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPE_1841	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPE_1845	COG0509	glycine decarboxylation via glycine cleavage system
TPE_1847	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPE_1849	COG1722	exodeoxyribonuclease VII activity
TPE_1850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TPE_1856	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPE_1858	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TPE_1860	COG1773	rubredoxin
TPE_1864	COG1692	metallophosphoesterase
TPE_1866	COG0142	geranyltranstransferase activity
TPE_1869	COG4555	ABC transporter
TPE_1876	COG1115	amino acid carrier protein
TPE_1878	COG2195	Cleaves the N-terminal amino acid of tripeptides
TPE_1880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TPE_1881	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPE_1884	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPE_1885	COG0156	8-amino-7-oxononanoate synthase activity
TPE_1887	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TPE_1888	COG2183	response to ionizing radiation
TPE_1889	COG1363	Peptidase, m42
TPE_1890	COG0281	malic enzyme
TPE_1893	COG2738	Putative neutral zinc metallopeptidase
TPE_1894	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TPE_1894	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TPE_1897	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TPE_1898	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPE_1901	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPE_1902	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TPE_1907	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPE_1908	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPE_1908	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TPE_1909	COG1329	Transcriptional regulator
TPE_1912	COG0577	efflux transmembrane transporter activity
TPE_1912	COG1136	(ABC) transporter
TPE_1914	COG0577	efflux transmembrane transporter activity
TPE_1914	COG1136	(ABC) transporter
TPE_1916	COG0009	L-threonylcarbamoyladenylate synthase
TPE_1922	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
TPE_1923	COG2204	response regulator
TPE_1924	COG0539	negative regulation of cytoplasmic translation
TPE_1928	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPE_1932	COG0497	DNA recombination
TPE_1936	COG1388	LysM domain
TPE_1937	COG1757	Na H antiporter
TPE_1938	COG0626	cystathionine gamma-synthase activity
TPE_1942	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPE_1944	COG0488	(ABC) transporter
TPE_1945	COG2723	6-phospho-beta-galactosidase activity
TPE_1946	COG2190	(PTS) system
TPE_1946	COG2211	Major facilitator Superfamily
TPE_1949	COG0557	exoribonuclease II activity
TPE_1954	COG2017	converts alpha-aldose to the beta-anomer
TPE_1956	COG1162	GTPase activity
TPE_1957	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TPE_1959	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPE_1960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPE_1962	COG2255	four-way junction helicase activity
TPE_1963	COG1979	alcohol dehydrogenase
TPE_1967	COG3880	PFAM UvrB UvrC protein
TPE_1969	COG1136	(ABC) transporter
TPE_1972	COG0552	protein localization to endoplasmic reticulum
TPE_1975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPE_1980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPE_1981	COG0210	DNA helicase
TPE_1984	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPE_1985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TPE_1987	COG2056	Na+-H+ antiporter family
TPE_1988	COG2056	Na+-H+ antiporter family
TPE_1991	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TPE_1992	COG1309	transcriptional regulator
TPE_1993	COG1132	(ABC) transporter
TPE_1994	COG1129	ABC transporter
TPE_1997	COG0488	(ABC) transporter
TPE_1999	COG2264	protein methyltransferase activity
TPE_2002	COG4608	Belongs to the ABC transporter superfamily
TPE_2003	COG0444	Belongs to the ABC transporter superfamily
TPE_2004	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_2005	COG0601	transmembrane transport
TPE_2007	COG0312	modulator of DNA gyrase
TPE_2012	COG2604	Protein of unknown function DUF115
TPE_2013	COG0484	heat shock protein binding
TPE_2015	COG0443	Heat shock 70 kDa protein
TPE_2016	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPE_2017	COG0284	orotidine-5'-phosphate decarboxylase activity
TPE_2019	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPE_2020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TPE_2022	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TPE_2024	COG0825	malonyl-CoA metabolic process
TPE_2025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TPE_2026	COG0439	Biotin carboxylase
TPE_2027	COG0511	ligase activity, forming carbon-carbon bonds
TPE_2028	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TPE_2029	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TPE_2030	COG1028	Short-chain dehydrogenase reductase Sdr
TPE_2031	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TPE_2032	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPE_2034	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPE_2039	COG0330	HflC and HflK could
TPE_2040	COG0330	HflC and HflK could
TPE_2042	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
TPE_2044	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TPE_2047	COG0835	chemotaxis
TPE_2049	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPE_2050	COG1132	(ABC) transporter
TPE_2051	COG2084	Dehydrogenase
TPE_2052	COG2986	histidine ammonia-lyase
TPE_2054	COG1131	(ABC) transporter
TPE_2057	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TPE_2086	COG0442	prolyl-tRNA aminoacylation
TPE_2088	COG4608	Belongs to the ABC transporter superfamily
TPE_2089	COG0444	Belongs to the ABC transporter superfamily
TPE_2090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_2091	COG0601	transmembrane transport
TPE_2092	COG4166	transmembrane transport
TPE_2095	COG2982	Protein involved in outer membrane biogenesis
TPE_2096	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
TPE_2097	COG0297	glycogen (starch) synthase activity
TPE_2098	COG4475	Protein of unknown function (DUF436)
TPE_2101	COG1472	Belongs to the glycosyl hydrolase 3 family
TPE_2104	COG1157	protein secretion by the type III secretion system
TPE_2105	COG1317	bacterial-type flagellum organization
TPE_2107	COG1766	The M ring may be actively involved in energy transduction
TPE_2108	COG1677	Flagellar hook-basal body complex protein FliE
TPE_2111	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TPE_2112	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TPE_2113	COG4974	Belongs to the 'phage' integrase family
TPE_2114	COG0551	DNA topoisomerase type I activity
TPE_2114	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPE_2115	COG0758	DNA mediated transformation
TPE_2115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPE_2118	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPE_2121	COG0772	Belongs to the SEDS family
TPE_2122	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPE_2124	COG0275	rRNA processing
TPE_2125	COG2001	Belongs to the MraZ family
TPE_2131	COG0513	Belongs to the DEAD box helicase family
TPE_2133	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TPE_2135	COG1739	Uncharacterized protein family UPF0029
TPE_2139	COG0747	negative chemotaxis
TPE_2140	COG0601	transmembrane transport
TPE_2141	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_2144	COG2226	methyltransferase
TPE_2147	COG0481	GTPase activity
TPE_2150	COG0750	zinc metalloprotease
TPE_2151	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPE_2152	COG0575	Belongs to the CDS family
TPE_2153	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPE_2154	COG0233	cytoplasmic translational termination
TPE_2155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPE_2156	COG0052	Belongs to the universal ribosomal protein uS2 family
TPE_2173	COG3209	COG3209 Rhs family protein
TPE_2184	COG0840	transmembrane signaling receptor activity
TPE_2187	COG0312	modulator of DNA gyrase
TPE_2188	COG0312	modulator of DNA gyrase
TPE_2189	COG3052	prosthetic group binding
TPE_2191	COG3051	citrate lyase alpha subunit
TPE_2194	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPE_2195	COG0484	heat shock protein binding
TPE_2196	COG0528	UMP kinase activity
TPE_2197	COG0736	holo-[acyl-carrier-protein] synthase activity
TPE_2199	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TPE_2200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPE_2201	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPE_2202	COG0424	maF-like protein
TPE_2203	COG1413	lyase activity
TPE_2205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_2206	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TPE_2207	COG1334	flagellar protein FlaG
TPE_2208	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPE_2208	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TPE_2211	COG0802	atpase or kinase
TPE_2213	COG3437	response regulator, receiver
TPE_2214	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPE_2215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TPE_2216	COG2204	response regulator
TPE_2227	COG0731	radical SAM domain protein
TPE_2231	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TPE_2232	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TPE_2233	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TPE_2237	COG1053	succinate dehydrogenase
TPE_2244	COG0606	chelatase, subunit chli
TPE_2246	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TPE_2247	COG3118	belongs to the thioredoxin family
TPE_2248	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPE_2252	COG0492	ferredoxin-NADP+ reductase activity
TPE_2254	COG4786	Flagellar basal body rod
TPE_2255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPE_2258	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPE_2259	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TPE_2260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPE_2266	COG0740	serine-type endopeptidase activity
TPE_2268	COG0193	aminoacyl-tRNA hydrolase activity
TPE_2275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TPE_2285	COG0653	protein targeting
TPE_2288	COG3706	GGDEF domain
TPE_2293	COG1639	'signal transduction protein
TPE_2295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TPE_2296	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPE_2297	COG1477	protein flavinylation
TPE_2298	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPE_2308	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TPE_2308	COG0493	'glutamate synthase
TPE_2310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPE_2311	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPE_2314	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPE_2318	COG0459	protein refolding
TPE_2320	COG5341	Protein conserved in bacteria
TPE_2321	COG0577	efflux transmembrane transporter activity
TPE_2321	COG1136	(ABC) transporter
TPE_2324	COG1132	(ABC) transporter
TPE_2330	COG1122	ATPase activity
TPE_2333	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TPE_2334	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPE_2337	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPE_2344	COG1131	(ABC) transporter
TPE_2345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPE_2346	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPE_2347	COG1862	Preprotein translocase
TPE_2348	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TPE_2349	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPE_2350	COG0571	ribonuclease III activity
TPE_2351	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TPE_2352	COG1573	uracil-dna glycosylase
TPE_2354	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPE_2355	COG0563	adenylate kinase activity
TPE_2359	COG0739	heme binding
TPE_2366	COG0556	nucleotide-excision repair
TPE_2367	COG0254	rRNA binding
TPE_2376	COG2217	Heavy metal translocating P-type atpase
TPE_2377	COG0640	Transcriptional regulator
TPE_2383	COG0784	Response regulator, receiver
TPE_2383	COG3437	response regulator, receiver
TPE_2384	COG1921	L-seryl-tRNASec selenium transferase activity
TPE_2385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPE_2387	COG2003	Belongs to the UPF0758 family
TPE_2389	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPE_2394	COG1132	(ABC) transporter
TPE_2396	COG0457	Tetratricopeptide repeat
TPE_2401	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TPE_2405	COG1132	(ABC) transporter
TPE_2441	COG0564	pseudouridine synthase activity
TPE_2444	COG4656	Part of a membrane complex involved in electron transport
TPE_2453	COG1175	transmembrane transport
TPE_2454	COG3833	ABC-type maltose transport systems, permease component
TPE_2455	COG3842	ATPase activity
TPE_2456	COG1640	4-alpha-glucanotransferase
TPE_2460	COG0779	Required for maturation of 30S ribosomal subunits
TPE_2462	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPE_2463	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPE_2464	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPE_2468	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPE_2469	COG0049	tRNA binding
TPE_2470	COG0791	NLP P60 protein
TPE_2471	COG0318	PFAM AMP-dependent synthetase and ligase
TPE_2480	COG1129	ABC transporter
TPE_2481	COG1609	Transcriptional regulator
TPE_2486	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPE_2487	COG0151	Belongs to the GarS family
TPE_2488	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPE_2489	COG0300	oxidoreductase activity
TPE_2490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TPE_2495	COG1704	LemA family
TPE_2497	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TPE_2498	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TPE_2499	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
TPE_2500	COG0482	sulfurtransferase activity
TPE_2510	COG4608	Belongs to the ABC transporter superfamily
TPE_2511	COG0444	Belongs to the ABC transporter superfamily
TPE_2512	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_2513	COG0601	transmembrane transport
TPE_2515	COG1505	serine-type exopeptidase activity
TPE_2517	COG4166	transmembrane transport
TPE_2519	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPE_2523	COG0617	tRNA 3'-terminal CCA addition
TPE_2528	COG1078	dGTPase activity
TPE_2530	COG0047	phosphoribosylformylglycinamidine synthase activity
TPE_2532	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPE_2533	COG0569	domain protein
TPE_2538	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPE_2539	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TPE_2540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TPE_2541	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TPE_2542	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPE_2543	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPE_2545	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TPE_2546	COG1671	Belongs to the UPF0178 family
TPE_2549	COG0444	Belongs to the ABC transporter superfamily
TPE_2550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPE_2551	COG0601	transmembrane transport
TPE_2552	COG0747	negative chemotaxis
TPE_2557	COG0840	transmembrane signaling receptor activity
TPE_2563	COG0335	large ribosomal subunit rRNA binding
TPE_2564	COG0336	Belongs to the RNA methyltransferase TrmD family
TPE_2565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPE_2566	COG1837	Belongs to the UPF0109 family
TPE_2567	COG0228	four-way junction DNA binding
TPE_2568	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPE_2570	COG1160	GTP binding
TPE_2572	COG1309	transcriptional regulator
TPE_2574	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPE_2575	COG1285	pathogenesis
TPE_2578	COG1131	(ABC) transporter
TPE_2579	COG4953	penicillin-binding protein 1C
TPE_2580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPE_2581	COG0084	hydrolase, TatD family'
TPE_2583	COG0709	Synthesizes selenophosphate from selenide and ATP
TPE_2586	COG1286	toxin biosynthetic process
TPE_2587	COG0470	DNA polymerase III
TPE_2588	COG5002	protein histidine kinase activity
TPE_2589	COG0450	alkyl hydroperoxide reductase
TPE_2590	COG0708	Exodeoxyribonuclease III
TPE_2591	COG0024	Methionine aminopeptidase
TPE_2592	COG0484	heat shock protein binding
TPE_2605	COG4211	Belongs to the binding-protein-dependent transport system permease family
TPE_2606	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPE_2612	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_2618	COG1132	(ABC) transporter
TPE_2620	COG0203	ribosomal protein L17
TPE_2621	COG0202	RNA polymerase activity
TPE_2622	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPE_2623	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPE_2626	COG0200	Binds to the 23S rRNA
TPE_2627	COG1841	ribosomal large subunit assembly
TPE_2628	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TPE_2629	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPE_2630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPE_2631	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPE_2632	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPE_2633	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPE_2634	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPE_2635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPE_2636	COG0255	Belongs to the universal ribosomal protein uL29 family
TPE_2637	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPE_2638	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPE_2640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPE_2641	COG0089	rRNA binding
TPE_2642	COG0088	Forms part of the polypeptide exit tunnel
TPE_2643	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPE_2644	COG0051	transcription antitermination factor activity, RNA binding
TPE_2645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPE_2647	COG0714	Associated with various cellular activities
TPE_2648	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TPE_2656	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPE_2659	COG0840	transmembrane signaling receptor activity
TPE_2662	COG0657	acetylesterase activity
TPE_2673	COG0488	(ABC) transporter
TPE_2679	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPE_2688	COG2378	regulation of single-species biofilm formation
TPE_2693	COG2207	Transcriptional regulator
TPE_2693	COG3708	Transcriptional regulator
TPE_2699	COG3976	FMN-binding domain protein
TPE_2699	COG1053	succinate dehydrogenase
TPE_2701	COG1120	ATPase activity
TPE_2702	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_2703	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPE_2704	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPE_2708	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TPE_2714	COG1067	ATP-dependent peptidase activity
TPE_2717	COG2241	protein methyltransferase activity
TPE_2720	COG0205	6-phosphofructokinase activity
TPE_2721	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TPE_2722	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TPE_2723	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPE_2727	COG0149	triose-phosphate isomerase activity
TPE_2728	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TPE_2729	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPE_2731	COG0534	Mate efflux family protein
TPE_2732	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPE_2733	COG0242	peptide deformylase activity
TPE_2734	COG0588	phosphoglycerate mutase activity
TPE_2739	COG0305	Participates in initiation and elongation during chromosome replication
TPE_2742	COG1193	negative regulation of DNA recombination
TPE_2745	COG2304	oxidoreductase activity
TPE_2750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TPE_2754	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_2755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPE_2756	COG1121	(ABC) transporter
TPE_2757	COG0803	Belongs to the bacterial solute-binding protein 9 family
TPE_2765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TPE_2766	COG3093	addiction module antidote protein HigA
TPE_2769	COG0205	6-phosphofructokinase activity
TPE_2774	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TPE_2776	COG1847	R3H domain protein
TPE_2777	COG0706	membrane insertase activity
TPE_2778	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TPE_2779	COG0594	ribonuclease P activity
TPE_2780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TPE_2782	COG0813	purine-nucleoside phosphorylase activity
TPE_2786	COG3706	GGDEF domain
TPE_2791	COG1234	tRNA 3'-trailer cleavage
TPE_2794	COG3951	Flagellar rod assembly protein muramidase FlgJ
TPE_2795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPE_2805	COG3842	ATPase activity
TPE_2806	COG0514	ATP-dependent DNA helicase (RecQ)
TPE_2808	COG0187	DNA topoisomerase II activity