locus-tag	class	description
IWA51_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IWA51_00010	COG0592	DNA-directed DNA polymerase activity
IWA51_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IWA51_00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IWA51_00035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IWA51_00040	COG0706	membrane insertase activity
IWA51_00045	COG1847	R3H domain protein
IWA51_00055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IWA51_00065	COG1643	Atp-dependent helicase
IWA51_00085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IWA51_00105	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IWA51_00110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IWA51_00160	COG1115	amino acid carrier protein
IWA51_00170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IWA51_00180	COG1639	'signal transduction protein
IWA51_00200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IWA51_00205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IWA51_00210	COG2011	ABC-type metal ion transport system permease component
IWA51_00215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IWA51_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IWA51_00270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IWA51_00280	COG0366	Alpha amylase catalytic
IWA51_00285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IWA51_00290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IWA51_00310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IWA51_00325	COG2201	protein-glutamate methylesterase activity
IWA51_00335	COG0643	Histidine kinase
IWA51_00335	COG0784	Response regulator, receiver
IWA51_00335	COG2198	Histidine kinase
IWA51_00360	COG0351	phosphomethylpyrimidine kinase
IWA51_00365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IWA51_00375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IWA51_00425	COG1104	cysteine desulfurase activity
IWA51_00445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IWA51_00455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IWA51_00460	COG1373	ATPase (AAA superfamily
IWA51_00465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IWA51_00470	COG1105	Belongs to the carbohydrate kinase PfkB family
IWA51_00485	COG1979	alcohol dehydrogenase
IWA51_00500	COG0583	DNA-binding transcription factor activity
IWA51_00510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IWA51_00520	COG1160	GTP binding
IWA51_00525	COG2885	chlorophyll binding
IWA51_00550	COG1309	transcriptional regulator
IWA51_00585	COG1442	glycosyl transferase family 8
IWA51_00605	COG0640	Transcriptional regulator
IWA51_00625	COG0210	DNA helicase
IWA51_00690	COG2801	Transposase and inactivated derivatives
IWA51_00810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IWA51_00810	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IWA51_00815	COG3040	lipid binding
IWA51_00820	COG1373	ATPase (AAA superfamily
IWA51_00855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IWA51_00865	COG3041	Addiction module toxin RelE StbE family
IWA51_00905	COG1918	ferrous iron import across plasma membrane
IWA51_00905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IWA51_00935	COG0577	efflux transmembrane transporter activity
IWA51_00935	COG1136	(ABC) transporter
IWA51_01000	COG0732	type I restriction modification DNA specificity domain
IWA51_01010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IWA51_01060	COG1401	restriction endodeoxyribonuclease activity
IWA51_01070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IWA51_01075	COG2011	ABC-type metal ion transport system permease component
IWA51_01080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IWA51_01090	COG0277	FAD linked oxidase domain protein
IWA51_01095	COG0039	L-malate dehydrogenase activity
IWA51_01105	COG0543	2 iron, 2 sulfur cluster binding
IWA51_01110	COG0493	'glutamate synthase
IWA51_01115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IWA51_01125	COG0367	asparagine synthase
IWA51_01135	COG0739	heme binding
IWA51_01150	COG1774	PSP1 C-terminal conserved region
IWA51_01160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IWA51_01165	COG0577	efflux transmembrane transporter activity
IWA51_01170	COG1136	(ABC) transporter
IWA51_01175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IWA51_01190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IWA51_01200	COG0732	type I restriction modification DNA specificity domain
IWA51_01205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IWA51_01215	COG1132	(ABC) transporter
IWA51_01255	COG0501	Belongs to the peptidase M48B family
IWA51_01260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IWA51_01300	COG2203	Gaf domain
IWA51_01300	COG3706	GGDEF domain
IWA51_01300	COG4251	negative regulation of phosphorylation
IWA51_01300	COG5001	Diguanylate cyclase
IWA51_01310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IWA51_01310	COG3116	cell division
IWA51_01315	COG0084	hydrolase, TatD family'
IWA51_01320	COG1464	Belongs to the NlpA lipoprotein family
IWA51_01325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWA51_01330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IWA51_01330	COG0574	Belongs to the PEP-utilizing enzyme family
IWA51_01340	COG0174	glutamine synthetase
IWA51_01345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IWA51_01375	COG1984	allophanate hydrolase subunit 2
IWA51_01380	COG4336	lyase activity
IWA51_01385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IWA51_01390	COG0840	transmembrane signaling receptor activity
IWA51_01410	COG0411	ABC transporter
IWA51_01420	COG1028	Short-chain dehydrogenase reductase Sdr
IWA51_01425	COG4377	Putative membrane peptidase family (DUF2324)
IWA51_01600	COG1783	phage Terminase large subunit
IWA51_01665	COG0629	single-stranded DNA binding
IWA51_01710	COG4536	flavin adenine dinucleotide binding
IWA51_01725	COG0564	pseudouridine synthase activity
IWA51_01765	COG0346	lactoylglutathione lyase activity
IWA51_01800	COG0456	acetyltransferase
IWA51_01880	COG1373	ATPase (AAA superfamily
IWA51_01930	COG3550	peptidyl-serine autophosphorylation
IWA51_01970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IWA51_01975	COG1335	isochorismatase
IWA51_01985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IWA51_01990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IWA51_02000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IWA51_02010	COG0840	transmembrane signaling receptor activity
IWA51_02015	COG1388	LysM domain
IWA51_02015	COG0741	lytic transglycosylase activity
IWA51_02035	COG1862	Preprotein translocase
IWA51_02040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IWA51_02045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IWA51_02050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IWA51_02060	COG3047	cAMP biosynthetic process
IWA51_02060	COG2885	chlorophyll binding
IWA51_02075	COG0107	imidazoleglycerol-phosphate synthase activity
IWA51_02080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IWA51_02090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IWA51_02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IWA51_02130	COG1760	l-serine dehydratase
IWA51_02135	COG1760	l-serine dehydratase
IWA51_02160	COG0789	Transcriptional regulator
IWA51_02170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IWA51_02175	COG1477	protein flavinylation
IWA51_02190	COG1285	pathogenesis
IWA51_02205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IWA51_02210	COG4120	Belongs to the binding-protein-dependent transport system permease family
IWA51_02215	COG0534	Mate efflux family protein
IWA51_02250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IWA51_02255	COG2165	general secretion pathway protein
IWA51_02305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IWA51_02315	COG0330	HflC and HflK could
IWA51_02320	COG0330	HflC and HflK could
IWA51_02325	COG0488	(ABC) transporter
IWA51_02340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IWA51_02345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IWA51_02355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IWA51_02360	COG0242	peptide deformylase activity
IWA51_02365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IWA51_02370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IWA51_02370	COG0140	phosphoribosyl-ATP diphosphatase activity
IWA51_02375	COG1122	ATPase activity
IWA51_02400	COG0714	Associated with various cellular activities
IWA51_02435	COG0484	heat shock protein binding
IWA51_02440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IWA51_02445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IWA51_02455	COG0784	Response regulator, receiver
IWA51_02455	COG5002	protein histidine kinase activity
IWA51_02455	COG2205	protein histidine kinase activity
IWA51_02465	COG0693	protein deglycase activity
IWA51_02485	COG1309	transcriptional regulator
IWA51_02505	COG1640	4-alpha-glucanotransferase
IWA51_02520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_02520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_02520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_02530	COG0205	6-phosphofructokinase activity
IWA51_02535	COG1704	LemA family
IWA51_02550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IWA51_02555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IWA51_02560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IWA51_02565	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IWA51_02575	COG1268	BioY protein
IWA51_02580	COG1122	ATPase activity
IWA51_02585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IWA51_02590	COG2816	NAD+ diphosphatase activity
IWA51_02595	COG1362	aminopeptidase activity
IWA51_02600	COG0151	Belongs to the GarS family
IWA51_02605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IWA51_02610	COG0131	Imidazoleglycerol-phosphate dehydratase
IWA51_02615	COG1522	sequence-specific DNA binding
IWA51_02620	COG0436	Aminotransferase
IWA51_02630	COG0357	Ribosomal RNA small subunit methyltransferase G
IWA51_02645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IWA51_02695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IWA51_02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IWA51_02740	COG1874	Beta-galactosidase
IWA51_02740	COG0366	Alpha amylase catalytic
IWA51_02745	COG1523	belongs to the glycosyl hydrolase 13 family
IWA51_02795	COG1187	pseudouridine synthase activity
IWA51_02800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IWA51_02810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IWA51_02815	COG0473	3-isopropylmalate dehydrogenase activity
IWA51_02820	COG2198	Histidine kinase
IWA51_02820	COG2205	protein histidine kinase activity
IWA51_02820	COG0784	Response regulator, receiver
IWA51_02825	COG0534	Mate efflux family protein
IWA51_02840	COG3177	Filamentation induced by cAMP protein fic
IWA51_02875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IWA51_02880	COG0154	amidase activity
IWA51_02885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IWA51_02895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IWA51_02915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IWA51_02920	COG0514	ATP-dependent DNA helicase (RecQ)
IWA51_02990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IWA51_02995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IWA51_03010	COG1523	belongs to the glycosyl hydrolase 13 family
IWA51_03020	COG1175	transmembrane transport
IWA51_03025	COG3833	ABC-type maltose transport systems, permease component
IWA51_03030	COG0366	Alpha amylase catalytic
IWA51_03055	COG0514	ATP-dependent DNA helicase (RecQ)
IWA51_03085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IWA51_03095	COG1028	Short-chain dehydrogenase reductase Sdr
IWA51_03110	COG0326	Molecular chaperone. Has ATPase activity
IWA51_03115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IWA51_03120	COG0569	domain protein
IWA51_03125	COG4684	Psort location CytoplasmicMembrane, score
IWA51_03130	COG0697	spore germination
IWA51_03140	COG0205	6-phosphofructokinase activity
IWA51_03155	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IWA51_03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWA51_03175	COG0765	amino acid transport
IWA51_03190	COG0228	four-way junction DNA binding
IWA51_03195	COG1837	Belongs to the UPF0109 family
IWA51_03200	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IWA51_03205	COG0336	Belongs to the RNA methyltransferase TrmD family
IWA51_03210	COG0335	large ribosomal subunit rRNA binding
IWA51_03220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IWA51_03250	COG0084	hydrolase, TatD family'
IWA51_03255	COG0166	Belongs to the GPI family
IWA51_03265	COG1438	arginine binding
IWA51_03270	COG1193	negative regulation of DNA recombination
IWA51_03275	COG0546	phosphoglycolate phosphatase activity
IWA51_03280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IWA51_03285	COG1121	(ABC) transporter
IWA51_03290	COG0803	Belongs to the bacterial solute-binding protein 9 family
IWA51_03305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IWA51_03310	COG0440	acetolactate synthase activity
IWA51_03340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IWA51_03350	COG0024	Methionine aminopeptidase
IWA51_03355	COG0484	heat shock protein binding
IWA51_03360	COG0018	arginyl-trna synthetase
IWA51_03370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IWA51_03460	COG4962	Type ii secretion system protein e
IWA51_03650	COG1192	Involved in chromosome partitioning
IWA51_03655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IWA51_03660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IWA51_03700	COG3118	belongs to the thioredoxin family
IWA51_03710	COG0523	cobalamin synthesis protein
IWA51_03720	COG3534	alpha-L-arabinofuranosidase
IWA51_03730	COG3534	alpha-L-arabinofuranosidase
IWA51_03735	COG0640	Transcriptional regulator
IWA51_03765	COG2033	superoxide reductase activity
IWA51_03770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IWA51_03775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IWA51_03785	COG0058	SHG alpha-glucan phosphorylase activity
IWA51_03795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWA51_03800	COG0765	amino acid transport
IWA51_03810	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IWA51_03815	COG1245	4Fe-4S binding domain
IWA51_03815	COG2878	Part of a membrane complex involved in electron transport
IWA51_03820	COG4657	Part of a membrane complex involved in electron transport
IWA51_03825	COG4660	Part of a membrane complex involved in electron transport
IWA51_03835	COG4658	electron transport chain
IWA51_03840	COG4656	Part of a membrane complex involved in electron transport
IWA51_03845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IWA51_03855	COG0105	UTP biosynthetic process
IWA51_03865	COG0372	Belongs to the citrate synthase family
IWA51_03875	COG0443	Heat shock 70 kDa protein
IWA51_03880	COG0484	heat shock protein binding
IWA51_03905	COG0495	leucyl-tRNA aminoacylation
IWA51_03910	COG2873	o-acetylhomoserine
IWA51_03915	COG0525	valine-tRNA ligase activity
IWA51_03930	COG0628	permease
IWA51_03935	COG0492	ferredoxin-NADP+ reductase activity
IWA51_03940	COG1472	Belongs to the glycosyl hydrolase 3 family
IWA51_03945	COG0564	pseudouridine synthase activity
IWA51_03965	COG1242	4 iron, 4 sulfur cluster binding
IWA51_03985	COG0534	Mate efflux family protein
IWA51_04005	COG3940	Belongs to the glycosyl hydrolase 43 family
IWA51_04040	COG0395	ABC-type sugar transport system, permease component
IWA51_04045	COG3507	Belongs to the glycosyl hydrolase 43 family
IWA51_04080	COG2199	diguanylate cyclase activity
IWA51_04080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IWA51_04110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IWA51_04175	COG0557	exoribonuclease II activity
IWA51_04185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IWA51_04190	COG4942	peptidase
IWA51_04205	COG0489	protein tyrosine kinase activity
IWA51_04225	COG0564	pseudouridine synthase activity
IWA51_04240	COG1418	mRNA catabolic process
IWA51_04250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IWA51_04250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_04250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_04255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IWA51_04275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IWA51_04290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IWA51_04295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IWA51_04310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IWA51_04320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IWA51_04325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IWA51_04330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IWA51_04335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IWA51_04370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IWA51_04380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IWA51_04390	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IWA51_04395	COG2502	aspartate--ammonia ligase
IWA51_04405	COG1971	Probably functions as a manganese efflux pump
IWA51_04420	COG0445	tRNA wobble uridine modification
IWA51_04425	COG1164	Oligoendopeptidase f
IWA51_04435	COG0488	(ABC) transporter
IWA51_04440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IWA51_04450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IWA51_04460	COG0318	PFAM AMP-dependent synthetase and ligase
IWA51_04465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IWA51_04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IWA51_04475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IWA51_04485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IWA51_04490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IWA51_04510	COG0799	negative regulation of ribosome biogenesis
IWA51_04525	COG2088	sporulation resulting in formation of a cellular spore
IWA51_04535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IWA51_04540	COG0037	tRNA processing
IWA51_04550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IWA51_04555	COG0481	GTPase activity
IWA51_04605	COG3330	Domain of unknown function (DUF4912)
IWA51_04645	COG1702	phosphate starvation-inducible protein PhoH
IWA51_04650	COG1480	7TM receptor with intracellular HD hydrolase
IWA51_04695	COG0552	protein localization to endoplasmic reticulum
IWA51_04705	COG4591	ABC-type transport system involved in lipoprotein release permease component
IWA51_04710	COG1136	(ABC) transporter
IWA51_04735	COG3977	Valine--pyruvate aminotransferase
IWA51_04740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IWA51_04750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IWA51_04765	COG1104	cysteine desulfurase activity
IWA51_04770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IWA51_04780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IWA51_04790	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IWA51_04800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IWA51_04810	COG0835	chemotaxis
IWA51_04815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IWA51_04820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IWA51_04825	COG0497	DNA recombination
IWA51_04850	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IWA51_04855	COG0420	3'-5' exonuclease activity
IWA51_04860	COG0419	ATPase involved in DNA repair
IWA51_04870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IWA51_04880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IWA51_04890	COG0739	heme binding
IWA51_04900	COG0708	Exodeoxyribonuclease III
IWA51_04915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IWA51_04925	COG0543	2 iron, 2 sulfur cluster binding
IWA51_04945	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IWA51_04970	COG1199	ATP-dependent helicase activity
IWA51_04985	COG0268	Binds directly to 16S ribosomal RNA
IWA51_04990	COG0776	regulation of translation
IWA51_05000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IWA51_05005	COG0254	rRNA binding
IWA51_05015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IWA51_05015	COG0116	Belongs to the methyltransferase superfamily
IWA51_05020	COG0513	Belongs to the DEAD box helicase family
IWA51_05025	COG0488	(ABC) transporter
IWA51_05060	COG0395	ABC-type sugar transport system, permease component
IWA51_05065	COG4209	transmembrane transport
IWA51_05070	COG2207	Transcriptional regulator
IWA51_05070	COG4753	response regulator
IWA51_05075	COG2972	Histidine kinase
IWA51_05080	COG1472	Belongs to the glycosyl hydrolase 3 family
IWA51_05090	COG2089	acid synthase
IWA51_05105	COG0217	transcriptional regulatory protein
IWA51_05115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IWA51_05135	COG0542	response to heat
IWA51_05145	COG0307	riboflavin synthase, alpha
IWA51_05150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IWA51_05150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IWA51_05180	COG0137	argininosuccinate synthase activity
IWA51_05185	COG1640	4-alpha-glucanotransferase
IWA51_05190	COG2059	Chromate
IWA51_05200	COG0813	purine-nucleoside phosphorylase activity
IWA51_05210	COG1482	cell wall glycoprotein biosynthetic process
IWA51_05215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IWA51_05230	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IWA51_05240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IWA51_05245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IWA51_05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IWA51_05340	COG0583	DNA-binding transcription factor activity
IWA51_05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IWA51_05425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IWA51_05425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IWA51_05440	COG0706	membrane insertase activity
IWA51_05450	COG5297	Belongs to the glycosyl hydrolase family 6
IWA51_05450	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IWA51_05455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IWA51_05460	COG1501	Belongs to the glycosyl hydrolase 31 family
IWA51_05470	COG1472	Belongs to the glycosyl hydrolase 3 family
IWA51_05495	COG2203	Gaf domain
IWA51_05495	COG3706	GGDEF domain
IWA51_05495	COG4251	negative regulation of phosphorylation
IWA51_05495	COG5001	Diguanylate cyclase
IWA51_05505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IWA51_05515	COG1126	abc transporter atp-binding protein
IWA51_05520	COG0765	amino acid transport
IWA51_05525	COG0765	amino acid transport
IWA51_05530	COG0670	Belongs to the BI1 family
IWA51_05540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IWA51_05560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IWA51_05575	COG1196	nuclear chromosome segregation
IWA51_05595	COG1132	(ABC) transporter
IWA51_05605	COG1309	transcriptional regulator
IWA51_05635	COG2226	methyltransferase
IWA51_05655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IWA51_05665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IWA51_05670	COG0740	serine-type endopeptidase activity
IWA51_05675	COG0544	peptidyl-prolyl cis-trans isomerase activity
IWA51_05720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IWA51_05725	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IWA51_05735	COG1214	PFAM Peptidase M22, glycoprotease
IWA51_05740	COG0802	atpase or kinase
IWA51_05775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IWA51_05795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IWA51_05810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IWA51_05820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IWA51_05825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IWA51_05845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IWA51_05865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IWA51_05870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IWA51_05885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IWA51_05885	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IWA51_05890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IWA51_05900	COG2002	toxin-antitoxin pair type II binding
IWA51_05910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IWA51_05950	COG1028	Short-chain dehydrogenase reductase Sdr
IWA51_05970	COG0656	L-ascorbic acid biosynthetic process
IWA51_05995	COG0463	Glycosyl transferase, family 2
IWA51_06000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IWA51_06010	COG3475	LICD family
IWA51_06015	COG1216	Glycosyl transferase, family 2
IWA51_06025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IWA51_06030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IWA51_06045	COG1216	Glycosyl transferase, family 2
IWA51_06125	COG0250	Participates in transcription elongation, termination and antitermination
IWA51_06130	COG1022	Amp-dependent synthetase and ligase
IWA51_06135	COG0180	Tryptophanyl-tRNA synthetase
IWA51_06140	COG0534	Mate efflux family protein
IWA51_06170	COG0297	glycogen (starch) synthase activity
IWA51_06195	COG0358	DNA primase activity
IWA51_06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IWA51_06220	COG1077	Cell shape determining protein MreB Mrl
IWA51_06235	COG0768	penicillin binding
IWA51_06240	COG0772	Belongs to the SEDS family
IWA51_06250	COG0617	tRNA 3'-terminal CCA addition
IWA51_06260	COG0564	pseudouridine synthase activity
IWA51_06315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IWA51_06315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IWA51_06320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IWA51_06335	COG0436	Aminotransferase
IWA51_06340	COG0297	glycogen (starch) synthase activity
IWA51_06350	COG0750	zinc metalloprotease
IWA51_06355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IWA51_06360	COG0575	Belongs to the CDS family
IWA51_06365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IWA51_06370	COG0233	cytoplasmic translational termination
IWA51_06375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IWA51_06380	COG0052	Belongs to the universal ribosomal protein uS2 family
IWA51_06385	COG0424	maF-like protein
IWA51_06395	COG1413	lyase activity
IWA51_06405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IWA51_06410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IWA51_06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IWA51_06420	COG0571	ribonuclease III activity
IWA51_06425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IWA51_06540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IWA51_06545	COG0285	dihydrofolate synthase activity
IWA51_06565	COG1234	tRNA 3'-trailer cleavage
IWA51_06620	COG1309	transcriptional regulator
IWA51_06635	COG0706	membrane insertase activity
IWA51_06645	COG0438	transferase activity, transferring glycosyl groups
IWA51_06670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IWA51_06680	COG1269	ATP hydrolysis coupled proton transport
IWA51_06685	COG1394	ATPase activity, coupled to movement of substances
IWA51_06690	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IWA51_06695	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IWA51_06705	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
IWA51_06730	COG1191	sigma factor activity
IWA51_06745	COG1419	protein localization to endoplasmic reticulum
IWA51_06755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IWA51_06760	COG1684	flagellar biosynthetic protein fliR
IWA51_06765	COG1987	bacterial-type flagellum assembly
IWA51_06770	COG1338	Plays a role in the flagellum-specific transport system
IWA51_06785	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IWA51_06790	COG1580	Controls the rotational direction of flagella during chemotaxis
IWA51_06795	COG1360	Flagellar Motor Protein
IWA51_06810	COG0745	RESPONSE REGULATOR receiver
IWA51_06815	COG5002	protein histidine kinase activity
IWA51_06820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IWA51_06870	COG2252	PERMEase
IWA51_06880	COG2267	carboxylic ester hydrolase activity
IWA51_06885	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IWA51_06905	COG1442	glycosyl transferase family 8
IWA51_06910	COG1216	Glycosyl transferase, family 2
IWA51_06910	COG1442	glycosyl transferase family 8
IWA51_07090	COG1783	phage Terminase large subunit
IWA51_07155	COG0629	single-stranded DNA binding
IWA51_07200	COG2246	polysaccharide biosynthetic process
IWA51_07205	COG0463	Glycosyl transferase, family 2
IWA51_07215	COG4115	mRNA cleavage
IWA51_07235	COG0463	Glycosyl transferase, family 2
IWA51_07260	COG0305	Participates in initiation and elongation during chromosome replication
IWA51_07265	COG0359	binds to the 23S rRNA
IWA51_07270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IWA51_07275	COG0629	single-stranded DNA binding
IWA51_07280	COG0360	Binds together with S18 to 16S ribosomal RNA
IWA51_07295	COG0742	ribosomal rna small subunit methyltransferase
IWA51_07310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IWA51_07320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IWA51_07325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IWA51_07330	COG0066	3-isopropylmalate dehydratase activity
IWA51_07335	COG1102	Psort location Cytoplasmic, score
IWA51_07340	COG1561	YicC-like family, N-terminal region
IWA51_07360	COG4786	Flagellar basal body rod
IWA51_07365	COG3300	MHYT domain
IWA51_07365	COG5001	Diguanylate cyclase
IWA51_07370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IWA51_07375	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IWA51_07380	COG2204	response regulator
IWA51_07385	COG3852	Histidine kinase
IWA51_07390	COG0470	DNA polymerase III
IWA51_07400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IWA51_07425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IWA51_07460	COG0301	tRNA thio-modification
IWA51_07480	COG1573	uracil-dna glycosylase
IWA51_07485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IWA51_07490	COG0101	tRNA pseudouridine synthase activity
IWA51_07500	COG0736	holo-[acyl-carrier-protein] synthase activity
IWA51_07515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IWA51_07520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IWA51_07525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IWA51_07535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IWA51_07545	COG0009	L-threonylcarbamoyladenylate synthase
IWA51_07580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IWA51_07590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IWA51_07600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IWA51_07645	COG2165	general secretion pathway protein
IWA51_07670	COG1086	Polysaccharide biosynthesis protein
IWA51_07675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IWA51_07695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IWA51_07700	COG2255	four-way junction helicase activity
IWA51_07705	COG0632	four-way junction helicase activity
IWA51_07715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IWA51_07720	COG0124	histidyl-tRNA synthetase
IWA51_07730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IWA51_07765	COG1388	LysM domain
IWA51_07765	COG0860	N-Acetylmuramoyl-L-alanine amidase
IWA51_07785	COG0731	radical SAM domain protein
IWA51_07790	COG1570	exodeoxyribonuclease VII activity
IWA51_07795	COG1722	exodeoxyribonuclease VII activity
IWA51_07800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IWA51_07880	COG0653	protein targeting
IWA51_07885	COG0681	Belongs to the peptidase S26 family
IWA51_07905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IWA51_07920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IWA51_07925	COG0719	Fe-S assembly protein
IWA51_07930	COG0719	Fe-S assembly protein
IWA51_07935	COG0396	ATPase activity
IWA51_07960	COG2204	response regulator
IWA51_07965	COG0539	negative regulation of cytoplasmic translation
IWA51_07975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IWA51_07980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IWA51_07985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IWA51_07990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IWA51_08010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IWA51_08025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IWA51_08025	COG1747	RNA polymerase binding
IWA51_08035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IWA51_08045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IWA51_08050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IWA51_08055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IWA51_08075	COG0583	DNA-binding transcription factor activity
IWA51_08100	COG1157	protein secretion by the type III secretion system
IWA51_08105	COG1317	bacterial-type flagellum organization
IWA51_08110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IWA51_08115	COG1766	The M ring may be actively involved in energy transduction
IWA51_08155	COG0732	type I restriction modification DNA specificity domain
IWA51_08160	COG0732	type I restriction modification DNA specificity domain
IWA51_08175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IWA51_08180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IWA51_08185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IWA51_08185	COG0551	DNA topoisomerase type I activity
IWA51_08190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IWA51_08190	COG0758	DNA mediated transformation
IWA51_08210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IWA51_08220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IWA51_08235	COG2001	Belongs to the MraZ family
IWA51_08255	COG0191	fructose-bisphosphate aldolase activity
IWA51_08275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IWA51_08285	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IWA51_08290	COG1671	Belongs to the UPF0178 family
IWA51_08295	COG3437	response regulator, receiver
IWA51_08295	COG0784	Response regulator, receiver
IWA51_08300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IWA51_08300	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IWA51_08305	COG1472	Belongs to the glycosyl hydrolase 3 family
IWA51_08315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IWA51_08340	COG0167	dihydroorotate dehydrogenase activity
IWA51_08355	COG1773	rubredoxin
IWA51_08355	COG1592	Rubrerythrin
IWA51_08365	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IWA51_08375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IWA51_08395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IWA51_08410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IWA51_08410	COG0446	pyridine nucleotide-disulphide oxidoreductase
IWA51_08425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IWA51_08445	COG0765	amino acid transport
IWA51_08455	COG2843	Capsule synthesis protein
IWA51_08470	COG0343	queuine tRNA-ribosyltransferase activity
IWA51_08485	COG0756	dUTP diphosphatase activity
IWA51_08495	COG1185	polyribonucleotide nucleotidyltransferase activity
IWA51_08500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IWA51_08510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IWA51_08515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IWA51_08540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_08540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_08540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_08555	COG0482	sulfurtransferase activity
IWA51_08560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IWA51_08565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IWA51_08570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IWA51_08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IWA51_08585	COG0745	RESPONSE REGULATOR receiver
IWA51_08590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IWA51_08595	COG1686	Belongs to the peptidase S11 family
IWA51_08605	COG1196	nuclear chromosome segregation
IWA51_08605	COG0739	heme binding
IWA51_08605	COG0741	lytic transglycosylase activity
IWA51_08615	COG0768	penicillin binding
IWA51_08635	COG0423	glycine-tRNA ligase activity
IWA51_08650	COG1744	ABC transporter substrate-binding protein PnrA-like
IWA51_08655	COG3845	ABC transporter
IWA51_08665	COG1079	Belongs to the binding-protein-dependent transport system permease family
IWA51_08675	COG1070	Carbohydrate kinase
IWA51_08685	COG5001	Diguanylate cyclase
IWA51_08690	COG2201	protein-glutamate methylesterase activity
IWA51_08700	COG0835	chemotaxis
IWA51_08705	COG0643	Histidine kinase
IWA51_08705	COG2198	Histidine kinase
IWA51_08715	COG0436	Aminotransferase
IWA51_08725	COG0745	RESPONSE REGULATOR receiver
IWA51_08735	COG1394	ATPase activity, coupled to movement of substances
IWA51_08740	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IWA51_08745	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IWA51_08765	COG1269	ATP hydrolysis coupled proton transport
IWA51_08780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_08780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IWA51_08780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_08795	COG0149	triose-phosphate isomerase activity
IWA51_08800	COG0126	phosphoglycerate kinase activity
IWA51_08805	COG0012	GTP binding
IWA51_08810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IWA51_08825	COG0251	oxidation-reduction process
IWA51_08830	COG0280	phosphate acetyltransferase
IWA51_08840	COG0724	RNA recognition motif
IWA51_08855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IWA51_08865	COG1739	Uncharacterized protein family UPF0029
IWA51_08895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IWA51_08900	COG0205	6-phosphofructokinase activity
IWA51_08915	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IWA51_08925	COG1469	GTP cyclohydrolase I activity
IWA51_08930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IWA51_08945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IWA51_08950	COG0563	adenylate kinase activity
IWA51_08960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IWA51_08960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IWA51_08980	COG0848	biopolymer transport protein
IWA51_09010	COG0728	peptidoglycan biosynthetic process
IWA51_09015	COG0006	proline dipeptidase activity
IWA51_09030	COG0322	excinuclease ABC activity
IWA51_09035	COG2207	Transcriptional regulator
IWA51_09035	COG3708	Transcriptional regulator
IWA51_09045	COG1216	Glycosyl transferase, family 2
IWA51_09095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IWA51_09105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IWA51_09115	COG0328	RNA-DNA hybrid ribonuclease activity
IWA51_09130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IWA51_09140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IWA51_09145	COG2890	protein-(glutamine-N5) methyltransferase activity
IWA51_09155	COG0826	peptidase U32
IWA51_09165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IWA51_09170	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IWA51_09180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IWA51_09185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IWA51_09190	COG1028	Short-chain dehydrogenase reductase Sdr
IWA51_09200	COG3706	GGDEF domain
IWA51_09205	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
IWA51_09210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IWA51_09245	COG0017	Asparaginyl-tRNA synthetase
IWA51_09260	COG0504	CTP synthase activity
IWA51_09270	COG0517	IMP dehydrogenase activity
IWA51_09270	COG1227	inorganic diphosphatase activity
IWA51_09275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IWA51_09290	COG0535	radical SAM domain protein
IWA51_09305	COG1121	(ABC) transporter
IWA51_09320	COG0028	Belongs to the TPP enzyme family
IWA51_09330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IWA51_09335	COG0646	methionine synthase
IWA51_09335	COG1410	methionine synthase
IWA51_09345	COG0513	Belongs to the DEAD box helicase family
IWA51_09355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IWA51_09375	COG3706	GGDEF domain
IWA51_09375	COG4251	negative regulation of phosphorylation
IWA51_09375	COG2203	Gaf domain
IWA51_09375	COG5001	Diguanylate cyclase
IWA51_09380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IWA51_09395	COG2003	Belongs to the UPF0758 family
IWA51_09410	COG0556	nucleotide-excision repair
IWA51_09415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IWA51_09420	COG0321	lipoyl(octanoyl) transferase activity
IWA51_09420	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IWA51_09425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IWA51_09460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IWA51_09475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IWA51_09480	COG0659	secondary active sulfate transmembrane transporter activity
IWA51_09485	COG1283	sodium-dependent phosphate transmembrane transporter activity
IWA51_09495	COG5002	protein histidine kinase activity
IWA51_09515	COG0616	signal peptide processing
IWA51_09520	COG0745	RESPONSE REGULATOR receiver
IWA51_09535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IWA51_09550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IWA51_09555	COG3842	ATPase activity
IWA51_09560	COG1176	ABC-type spermidine putrescine transport system, permease component I
IWA51_09565	COG1177	transmembrane transport
IWA51_09570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IWA51_09585	COG2885	chlorophyll binding
IWA51_09590	COG3459	Glycosyltransferase 36 associated
IWA51_09615	COG1131	(ABC) transporter
IWA51_09620	COG0587	DNA-directed DNA polymerase activity
IWA51_09625	COG0762	integral membrane protein
IWA51_09630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IWA51_09635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IWA51_09640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IWA51_09650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IWA51_09655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IWA51_09660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IWA51_09700	COG2264	protein methyltransferase activity
IWA51_09710	COG1396	sequence-specific DNA binding
IWA51_09770	COG2272	Belongs to the type-B carboxylesterase lipase family
IWA51_09795	COG0583	DNA-binding transcription factor activity
IWA51_09830	COG1846	Transcriptional regulator
IWA51_09845	COG3340	Belongs to the peptidase S51 family
IWA51_09870	COG3041	Addiction module toxin RelE StbE family
IWA51_09880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IWA51_09955	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IWA51_09975	COG0534	Mate efflux family protein
IWA51_09980	COG2364	Membrane
IWA51_09985	COG0004	ammonium transporteR
IWA51_10010	COG0840	transmembrane signaling receptor activity
IWA51_10015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IWA51_10035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IWA51_10045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IWA51_10050	COG0581	inorganic phosphate transmembrane transporter activity
IWA51_10055	COG0573	inorganic phosphate transmembrane transporter activity
IWA51_10065	COG2357	RelA SpoT domain protein
IWA51_10070	COG0534	Mate efflux family protein
IWA51_10075	COG0791	NLP P60 protein
IWA51_10100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IWA51_10105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IWA51_10110	COG1181	Belongs to the D-alanine--D-alanine ligase family
IWA51_10115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IWA51_10120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IWA51_10125	COG0517	IMP dehydrogenase activity
IWA51_10125	COG0516	GMP reductase activity
IWA51_10135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IWA51_10140	COG1516	flagellar protein fliS
IWA51_10150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IWA51_10150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IWA51_10150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IWA51_10155	COG0237	dephospho-CoA kinase activity
IWA51_10165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IWA51_10200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IWA51_10215	COG0740	serine-type endopeptidase activity
IWA51_10220	COG3956	TIGRFAM MazG family protein
IWA51_10225	COG0193	aminoacyl-tRNA hydrolase activity
IWA51_10280	COG2217	Heavy metal translocating P-type atpase
IWA51_10285	COG0640	Transcriptional regulator
IWA51_10290	COG2207	Transcriptional regulator
IWA51_10290	COG1917	Cupin 2, conserved barrel domain protein
IWA51_10300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IWA51_10310	COG4211	Belongs to the binding-protein-dependent transport system permease family
IWA51_10315	COG1129	ABC transporter
IWA51_10320	COG1879	ABC-type sugar transport system periplasmic component
IWA51_10420	COG1773	rubredoxin
IWA51_10420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IWA51_10465	COG0028	Belongs to the TPP enzyme family
IWA51_10475	COG3459	Glycosyltransferase 36 associated
IWA51_10480	COG3833	ABC-type maltose transport systems, permease component
IWA51_10485	COG1175	transmembrane transport
IWA51_10525	COG0442	prolyl-tRNA aminoacylation
IWA51_10540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IWA51_10545	COG0626	cystathionine gamma-synthase activity
IWA51_10570	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IWA51_10575	COG1373	ATPase (AAA superfamily
IWA51_10595	COG1388	LysM domain
IWA51_10595	COG3103	Sh3 type 3 domain protein
IWA51_10595	COG0791	NLP P60 protein
IWA51_10610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IWA51_10625	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IWA51_10645	COG1047	Peptidyl-prolyl cis-trans
IWA51_10660	COG0741	lytic transglycosylase activity
IWA51_10670	COG1592	Rubrerythrin
IWA51_10680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IWA51_10695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IWA51_10695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IWA51_10710	COG1854	S-ribosylhomocysteine lyase activity
IWA51_10715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IWA51_10720	COG1534	Rna-binding protein
IWA51_10725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IWA51_10725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IWA51_10755	COG0512	Glutamine amidotransferase of anthranilate synthase
IWA51_10755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IWA51_10765	COG0133	tryptophan synthase activity
IWA51_10770	COG0159	tryptophan synthase activity
IWA51_10775	COG4716	Myosin-crossreactive antigen
IWA51_10800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IWA51_10805	COG2207	Transcriptional regulator
IWA51_10815	COG1475	DNA binding
IWA51_10820	COG1192	Involved in chromosome partitioning
IWA51_10825	COG0784	Response regulator, receiver
IWA51_10825	COG2198	Histidine kinase
IWA51_10825	COG2205	protein histidine kinase activity
IWA51_10845	COG0534	Mate efflux family protein
IWA51_10895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IWA51_10900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IWA51_10930	COG4974	Belongs to the 'phage' integrase family
IWA51_10940	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IWA51_10950	COG1966	Carbon starvation protein
IWA51_10970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IWA51_10975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IWA51_10980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IWA51_10985	COG1272	protein, Hemolysin III
IWA51_10990	COG3012	SEC-C Motif Domain Protein
IWA51_11020	COG1022	Amp-dependent synthetase and ligase
IWA51_11060	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IWA51_11065	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IWA51_11085	COG0793	Belongs to the peptidase S41A family
IWA51_11090	COG0455	bacterial-type flagellum organization
IWA51_11095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IWA51_11105	COG0138	bifunctional purine biosynthesis protein purh
IWA51_11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IWA51_11135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IWA51_11140	COG0215	cysteine-tRNA ligase activity
IWA51_11145	COG1595	DNA-templated transcription, initiation
IWA51_11160	COG0528	UMP kinase activity
IWA51_11170	COG0318	PFAM AMP-dependent synthetase and ligase
IWA51_11185	COG2703	oxygen carrier activity
IWA51_11190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IWA51_11220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IWA51_11230	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IWA51_11235	COG1028	Short-chain dehydrogenase reductase Sdr
IWA51_11240	COG0019	diaminopimelate decarboxylase activity
IWA51_11300	COG0494	nUDIX hydrolase
IWA51_11315	COG4443	Transcriptional Coactivator p15 (PC4)
IWA51_11330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWA51_11370	COG3845	ABC transporter
IWA51_11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IWA51_11390	COG1757	Na H antiporter
IWA51_11400	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IWA51_11475	COG0556	nucleotide-excision repair
IWA51_11505	COG0493	'glutamate synthase
IWA51_11510	COG0070	glutamate synthase
IWA51_11510	COG0069	glutamate synthase activity
IWA51_11510	COG0067	glutamate synthase
IWA51_11515	COG1968	undecaprenyl-diphosphatase activity
IWA51_11520	COG0840	transmembrane signaling receptor activity
IWA51_11530	COG0824	Thioesterase
IWA51_11545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IWA51_11560	COG1595	DNA-templated transcription, initiation
IWA51_11570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IWA51_11575	COG0741	lytic transglycosylase activity
IWA51_11575	COG1196	nuclear chromosome segregation
IWA51_11575	COG0739	heme binding
IWA51_11585	COG2201	protein-glutamate methylesterase activity
IWA51_11605	COG0504	CTP synthase activity
IWA51_11620	COG1137	ATPase activity
IWA51_11625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IWA51_11625	COG0617	tRNA 3'-terminal CCA addition
IWA51_11625	COG0517	IMP dehydrogenase activity
IWA51_11660	COG0203	ribosomal protein L17
IWA51_11665	COG0202	RNA polymerase activity
IWA51_11675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IWA51_11680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IWA51_11685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IWA51_11695	COG0200	Binds to the 23S rRNA
IWA51_11700	COG1841	ribosomal large subunit assembly
IWA51_11705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IWA51_11710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IWA51_11715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IWA51_11720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IWA51_11725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IWA51_11730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IWA51_11735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IWA51_11740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IWA51_11745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IWA51_11750	COG0255	Belongs to the universal ribosomal protein uL29 family
IWA51_11760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IWA51_11765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IWA51_11770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IWA51_11775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IWA51_11780	COG0089	rRNA binding
IWA51_11785	COG0088	Forms part of the polypeptide exit tunnel
IWA51_11790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IWA51_11795	COG0051	transcription antitermination factor activity, RNA binding
IWA51_11800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IWA51_11805	COG0049	tRNA binding
IWA51_11810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IWA51_11820	COG0085	RNA polymerase activity
IWA51_11825	COG0222	ribosome binding
IWA51_11830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IWA51_11835	COG0081	regulation of translation
IWA51_11840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IWA51_11845	COG0250	Participates in transcription elongation, termination and antitermination
IWA51_11850	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IWA51_11860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IWA51_11870	COG1045	serine acetyltransferase
IWA51_11890	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IWA51_11910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IWA51_11925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IWA51_11930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IWA51_11940	COG4166	transmembrane transport
IWA51_11955	COG0668	transmembrane transport
IWA51_11960	COG3191	aminopeptidase activity
IWA51_11965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IWA51_11975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IWA51_11980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IWA51_11990	COG0501	Belongs to the peptidase M48B family
IWA51_12025	COG1119	ATPase activity
IWA51_12030	COG3858	chitin binding
IWA51_12035	COG1674	ftsk spoiiie
IWA51_12050	COG1172	Belongs to the binding-protein-dependent transport system permease family
IWA51_12055	COG1172	Belongs to the binding-protein-dependent transport system permease family
IWA51_12065	COG1879	ABC-type sugar transport system periplasmic component
IWA51_12070	COG2207	Transcriptional regulator
IWA51_12070	COG4753	response regulator
IWA51_12075	COG2972	Histidine kinase
IWA51_12080	COG1879	ABC-type sugar transport system periplasmic component
IWA51_12085	COG5001	Diguanylate cyclase
IWA51_12085	COG3300	MHYT domain
IWA51_12090	COG1346	cytolysis
IWA51_12095	COG1380	Effector of murein hydrolase LrgA
IWA51_12110	COG0534	Mate efflux family protein
IWA51_12130	COG0284	orotidine-5'-phosphate decarboxylase activity
IWA51_12140	COG0295	cytidine deaminase activity
IWA51_12155	COG2358	TRAP transporter, solute receptor (TAXI family
IWA51_12200	COG4977	sequence-specific DNA binding
IWA51_12205	COG0006	proline dipeptidase activity
IWA51_12220	COG1373	ATPase (AAA superfamily
IWA51_12230	COG1373	ATPase (AAA superfamily
IWA51_12260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IWA51_12340	COG0534	Mate efflux family protein
IWA51_12360	COG1328	CTP reductase activity
IWA51_12365	COG0840	transmembrane signaling receptor activity
IWA51_12380	COG4608	Belongs to the ABC transporter superfamily
IWA51_12390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IWA51_12390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IWA51_12395	COG0601	transmembrane transport
IWA51_12420	COG0116	Belongs to the methyltransferase superfamily
IWA51_12420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IWA51_12435	COG1487	ribonuclease activity
IWA51_12465	COG2183	response to ionizing radiation
IWA51_12470	COG5278	phosphoserine phosphatase activity
IWA51_12470	COG0840	transmembrane signaling receptor activity
IWA51_12475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IWA51_12490	COG1051	belongs to the nudix hydrolase family
IWA51_12500	COG0622	Phosphoesterase
IWA51_12510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IWA51_12520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IWA51_12520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IWA51_12525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IWA51_12530	COG0187	DNA topoisomerase II activity