locus-tag	class	description
C5O78_00010	COG1879	ABC-type sugar transport system periplasmic component
C5O78_00015	COG1692	metallophosphoesterase
C5O78_00025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5O78_00045	COG1115	amino acid carrier protein
C5O78_00055	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5O78_00075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5O78_00095	COG0530	calcium, potassium:sodium antiporter activity
C5O78_00115	COG0321	lipoyl(octanoyl) transferase activity
C5O78_00115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5O78_00135	COG2204	response regulator
C5O78_00140	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5O78_00150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5O78_00170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5O78_00195	COG0405	Gamma-glutamyltransferase
C5O78_00210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5O78_00215	COG0587	DNA-directed DNA polymerase activity
C5O78_00220	COG0762	integral membrane protein
C5O78_00225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5O78_00230	COG0584	glycerophosphoryl diester phosphodiesterase
C5O78_00235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5O78_00245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5O78_00250	COG0542	response to heat
C5O78_00280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5O78_00285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5O78_00295	COG0457	Tetratricopeptide repeat
C5O78_00300	COG1475	DNA binding
C5O78_00305	COG1438	arginine binding
C5O78_00310	COG0251	oxidation-reduction process
C5O78_00330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C5O78_00340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O78_00380	COG2244	polysaccharide biosynthetic process
C5O78_00395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_00440	COG0673	inositol 2-dehydrogenase activity
C5O78_00450	COG0028	Belongs to the TPP enzyme family
C5O78_00450	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C5O78_00495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5O78_00515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5O78_00530	COG1178	ABC-type Fe3 transport system permease component
C5O78_00535	COG3842	ATPase activity
C5O78_00550	COG0363	glucosamine-6-phosphate deaminase activity
C5O78_00555	COG0714	Associated with various cellular activities
C5O78_00565	COG1305	Transglutaminase-like
C5O78_00570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5O78_00585	COG0706	membrane insertase activity
C5O78_00590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5O78_00600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5O78_00610	COG1640	4-alpha-glucanotransferase
C5O78_00615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5O78_00625	COG3328	transposase activity
C5O78_00630	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5O78_00635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_00655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5O78_00685	COG2932	Transcriptional regulator
C5O78_01080	COG1879	ABC-type sugar transport system periplasmic component
C5O78_01085	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_01090	COG1129	ABC transporter
C5O78_01095	COG1869	D-ribose catabolic process
C5O78_01120	COG0835	chemotaxis
C5O78_01125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_01130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5O78_01135	COG0497	DNA recombination
C5O78_01150	COG0671	phosphoesterase, PA-phosphatase related
C5O78_01155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_01165	COG0601	transmembrane transport
C5O78_01170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5O78_01175	COG0444	Belongs to the ABC transporter superfamily
C5O78_01180	COG4608	Belongs to the ABC transporter superfamily
C5O78_01195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5O78_01215	COG0534	Mate efflux family protein
C5O78_01220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5O78_01230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5O78_01235	COG2911	Protein conserved in bacteria
C5O78_01240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_01250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5O78_01265	COG3037	sugar-specific permease SgaT UlaA
C5O78_01275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_01275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_01280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_01310	COG1175	transmembrane transport
C5O78_01315	COG0395	ABC-type sugar transport system, permease component
C5O78_01320	COG0514	ATP-dependent DNA helicase (RecQ)
C5O78_01345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_01355	COG1686	Belongs to the peptidase S11 family
C5O78_01370	COG1418	mRNA catabolic process
C5O78_01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5O78_01405	COG2604	Protein of unknown function DUF115
C5O78_01425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5O78_01465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5O78_01470	COG4750	Nucleotidyl transferase
C5O78_01495	COG1570	exodeoxyribonuclease VII activity
C5O78_01505	COG1362	aminopeptidase activity
C5O78_01520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5O78_01525	COG2255	four-way junction helicase activity
C5O78_01560	COG2738	Putative neutral zinc metallopeptidase
C5O78_01610	COG0297	glycogen (starch) synthase activity
C5O78_01685	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C5O78_01695	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5O78_01700	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5O78_01705	COG1394	ATPase activity, coupled to movement of substances
C5O78_01710	COG1269	ATP hydrolysis coupled proton transport
C5O78_01720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5O78_01725	COG2832	Protein of unknown function (DUF454)
C5O78_01730	COG0285	dihydrofolate synthase activity
C5O78_01755	COG2333	competence protein COMEC
C5O78_01755	COG0658	competence protein
C5O78_01780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5O78_01785	COG2890	protein-(glutamine-N5) methyltransferase activity
C5O78_01790	COG1022	Amp-dependent synthetase and ligase
C5O78_01800	COG1321	iron dependent repressor
C5O78_01805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_01810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_01815	COG1121	(ABC) transporter
C5O78_01820	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5O78_01830	COG1879	ABC-type sugar transport system periplasmic component
C5O78_01835	COG1129	ABC transporter
C5O78_01840	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5O78_01855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5O78_01885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_01885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_01885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_01910	COG0484	heat shock protein binding
C5O78_01915	COG0443	Heat shock 70 kDa protein
C5O78_01920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5O78_01925	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5O78_01930	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5O78_01950	COG1269	ATP hydrolysis coupled proton transport
C5O78_01955	COG1527	subunit (C
C5O78_01965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_01965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_01965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_01970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5O78_01985	COG2313	pseudouridylate synthase activity
C5O78_01990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_01995	COG2001	Belongs to the MraZ family
C5O78_02000	COG0275	rRNA processing
C5O78_02010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5O78_02015	COG0772	Belongs to the SEDS family
C5O78_02020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5O78_02030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5O78_02035	COG4974	Belongs to the 'phage' integrase family
C5O78_02045	COG0758	DNA mediated transformation
C5O78_02050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5O78_02050	COG0551	DNA topoisomerase type I activity
C5O78_02055	COG4974	Belongs to the 'phage' integrase family
C5O78_02060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5O78_02065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5O78_02075	COG1815	bacterial-type flagellum-dependent cell motility
C5O78_02090	COG1766	The M ring may be actively involved in energy transduction
C5O78_02100	COG1317	bacterial-type flagellum organization
C5O78_02105	COG1157	protein secretion by the type III secretion system
C5O78_02125	COG0019	diaminopimelate decarboxylase activity
C5O78_02140	COG0438	transferase activity, transferring glycosyl groups
C5O78_02170	COG2186	Transcriptional regulator
C5O78_02180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5O78_02205	COG1490	D-aminoacyl-tRNA deacylase activity
C5O78_02210	COG0193	aminoacyl-tRNA hydrolase activity
C5O78_02230	COG1473	amidohydrolase
C5O78_02245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O78_02255	COG0545	Peptidyl-prolyl cis-trans isomerase
C5O78_02275	COG2217	Heavy metal translocating P-type atpase
C5O78_02285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_02290	COG0813	purine-nucleoside phosphorylase activity
C5O78_02295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5O78_02305	COG0840	transmembrane signaling receptor activity
C5O78_02340	COG5002	protein histidine kinase activity
C5O78_02350	COG0704	Plays a role in the regulation of phosphate uptake
C5O78_02355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5O78_02360	COG0581	inorganic phosphate transmembrane transporter activity
C5O78_02365	COG0573	inorganic phosphate transmembrane transporter activity
C5O78_02370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5O78_02400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5O78_02435	COG0305	Participates in initiation and elongation during chromosome replication
C5O78_02440	COG0359	binds to the 23S rRNA
C5O78_02445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5O78_02450	COG0629	single-stranded DNA binding
C5O78_02455	COG0360	Binds together with S18 to 16S ribosomal RNA
C5O78_02465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O78_02475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5O78_02505	COG0084	hydrolase, TatD family'
C5O78_02510	COG3116	cell division
C5O78_02510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5O78_02555	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5O78_02560	COG0740	serine-type endopeptidase activity
C5O78_02565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5O78_02585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5O78_02595	COG0455	bacterial-type flagellum organization
C5O78_02610	COG3330	Domain of unknown function (DUF4912)
C5O78_02615	COG1285	pathogenesis
C5O78_02655	COG0534	Mate efflux family protein
C5O78_02695	COG0187	DNA topoisomerase II activity
C5O78_02710	COG2081	HI0933 family
C5O78_02715	COG1053	succinate dehydrogenase
C5O78_02720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5O78_02725	COG0049	tRNA binding
C5O78_02790	COG3621	Patatin-like phospholipase
C5O78_02860	COG0840	transmembrane signaling receptor activity
C5O78_02880	COG1132	(ABC) transporter
C5O78_02950	COG2197	response regulator
C5O78_02955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_02975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5O78_02985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5O78_03005	COG0167	dihydroorotate dehydrogenase activity
C5O78_03020	COG1199	ATP-dependent helicase activity
C5O78_03025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5O78_03030	COG0006	proline dipeptidase activity
C5O78_03040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_03075	COG0484	heat shock protein binding
C5O78_03080	COG0024	Methionine aminopeptidase
C5O78_03095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C5O78_03115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5O78_03160	COG0840	transmembrane signaling receptor activity
C5O78_03175	COG1053	succinate dehydrogenase
C5O78_03175	COG3976	FMN-binding domain protein
C5O78_03175	COG0431	NADPH-dependent FMN reductase
C5O78_03220	COG0840	transmembrane signaling receptor activity
C5O78_03250	COG0357	Ribosomal RNA small subunit methyltransferase G
C5O78_03255	COG1757	Na H antiporter
C5O78_03270	COG2801	Transposase and inactivated derivatives
C5O78_03295	COG0733	neurotransmitter:sodium symporter activity
C5O78_03300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5O78_03310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5O78_03330	COG2116	formate transmembrane transporter activity
C5O78_03335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5O78_03360	COG4536	flavin adenine dinucleotide binding
C5O78_03365	COG1253	flavin adenine dinucleotide binding
C5O78_03370	COG0800	Aldolase
C5O78_03390	COG3706	GGDEF domain
C5O78_03395	COG3706	GGDEF domain
C5O78_03410	COG1653	transport
C5O78_03420	COG0395	ABC-type sugar transport system, permease component
C5O78_03465	COG2885	chlorophyll binding
C5O78_03495	COG0653	protein targeting
C5O78_03510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C5O78_03540	COG2056	Na+-H+ antiporter family
C5O78_03545	COG2986	histidine ammonia-lyase
C5O78_03560	COG3404	Formiminotransferase-cyclodeaminase
C5O78_03580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5O78_03585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5O78_03595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5O78_03595	COG0493	'glutamate synthase
C5O78_03600	COG0402	S-adenosylhomocysteine deaminase activity
C5O78_03615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5O78_03620	COG3608	succinylglutamate desuccinylase aspartoacylase
C5O78_03620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5O78_03625	COG1058	Belongs to the CinA family
C5O78_03625	COG1546	Belongs to the CinA family
C5O78_03630	COG0315	cyclic pyranopterin monophosphate synthase activity
C5O78_03645	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5O78_03655	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5O78_03660	COG4149	molybdate abc transporter
C5O78_03665	COG3842	ATPase activity
C5O78_03670	COG0746	molybdenum cofactor guanylyltransferase activity
C5O78_03675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5O78_03675	COG3608	succinylglutamate desuccinylase aspartoacylase
C5O78_03680	COG0709	Synthesizes selenophosphate from selenide and ATP
C5O78_03695	COG1104	cysteine desulfurase activity
C5O78_03705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O78_03710	COG0772	Belongs to the SEDS family
C5O78_03715	COG0768	penicillin binding
C5O78_03730	COG1077	Cell shape determining protein MreB Mrl
C5O78_03750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_03755	COG0358	DNA primase activity
C5O78_03760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5O78_03770	COG1234	tRNA 3'-trailer cleavage
C5O78_03790	COG4656	Part of a membrane complex involved in electron transport
C5O78_03795	COG4658	electron transport chain
C5O78_03805	COG4660	Part of a membrane complex involved in electron transport
C5O78_03810	COG4657	Part of a membrane complex involved in electron transport
C5O78_03815	COG1245	4Fe-4S binding domain
C5O78_03815	COG2878	Part of a membrane complex involved in electron transport
C5O78_03820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5O78_03830	COG1598	PFAM Uncharacterised protein family UPF0150
C5O78_03835	COG2211	Major facilitator Superfamily
C5O78_03840	COG3064	Membrane
C5O78_03885	COG1254	Belongs to the acylphosphatase family
C5O78_03895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_03905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5O78_03915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5O78_03920	COG0745	RESPONSE REGULATOR receiver
C5O78_03930	COG1136	(ABC) transporter
C5O78_03950	COG4585	Histidine kinase
C5O78_03970	COG1131	(ABC) transporter
C5O78_03975	COG0513	Belongs to the DEAD box helicase family
C5O78_03980	COG0577	efflux transmembrane transporter activity
C5O78_03985	COG0577	efflux transmembrane transporter activity
C5O78_03990	COG1136	(ABC) transporter
C5O78_04005	COG0052	Belongs to the universal ribosomal protein uS2 family
C5O78_04010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5O78_04015	COG0233	cytoplasmic translational termination
C5O78_04020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5O78_04025	COG4589	Belongs to the CDS family
C5O78_04030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5O78_04035	COG0750	zinc metalloprotease
C5O78_04060	COG0681	Belongs to the peptidase S26 family
C5O78_04065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5O78_04070	COG0616	signal peptide processing
C5O78_04085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5O78_04100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5O78_04115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5O78_04115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5O78_04120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5O78_04125	COG0617	tRNA 3'-terminal CCA addition
C5O78_04135	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5O78_04150	COG0629	single-stranded DNA binding
C5O78_04155	COG0205	6-phosphofructokinase activity
C5O78_04165	COG0494	nUDIX hydrolase
C5O78_04185	COG0488	(ABC) transporter
C5O78_04200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O78_04205	COG0786	glutamate:sodium symporter activity
C5O78_04215	COG4770	biotin carboxylase activity
C5O78_04220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C5O78_04225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5O78_04230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5O78_04235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5O78_04240	COG0786	glutamate:sodium symporter activity
C5O78_04250	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5O78_04255	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5O78_04265	COG4209	transmembrane transport
C5O78_04275	COG0395	ABC-type sugar transport system, permease component
C5O78_04300	COG4475	Protein of unknown function (DUF436)
C5O78_04305	COG1136	(ABC) transporter
C5O78_04345	COG1983	PspC domain protein
C5O78_04365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5O78_04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O78_04380	COG0280	phosphate acetyltransferase
C5O78_04385	COG0457	Tetratricopeptide repeat
C5O78_04390	COG2205	protein histidine kinase activity
C5O78_04390	COG0784	Response regulator, receiver
C5O78_04390	COG5002	protein histidine kinase activity
C5O78_04395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5O78_04400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5O78_04410	COG0528	UMP kinase activity
C5O78_04415	COG1305	Transglutaminase-like
C5O78_04430	COG0215	cysteine-tRNA ligase activity
C5O78_04435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5O78_04440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5O78_04460	COG2201	protein-glutamate methylesterase activity
C5O78_04470	COG2801	Transposase and inactivated derivatives
C5O78_04485	COG2887	Belongs to the helicase family. UvrD subfamily
C5O78_04490	COG1074	ATP-dependent DNA helicase activity
C5O78_04495	COG0840	transmembrane signaling receptor activity
C5O78_04525	COG0217	transcriptional regulatory protein
C5O78_04535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5O78_04540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5O78_04545	COG0840	transmembrane signaling receptor activity
C5O78_04560	COG3842	ATPase activity
C5O78_04565	COG1178	ABC-type Fe3 transport system permease component
C5O78_04570	COG3842	ATPase activity
C5O78_04580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5O78_04620	COG1253	flavin adenine dinucleotide binding
C5O78_04640	COG1882	Formate acetyltransferase
C5O78_04645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5O78_04675	COG0643	Histidine kinase
C5O78_04675	COG2198	Histidine kinase
C5O78_04680	COG0835	chemotaxis
C5O78_04690	COG2201	protein-glutamate methylesterase activity
C5O78_04705	COG1196	nuclear chromosome segregation
C5O78_04715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_04720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5O78_04745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5O78_04770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5O78_04775	COG2088	sporulation resulting in formation of a cellular spore
C5O78_04785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5O78_04790	COG0037	tRNA processing
C5O78_04795	COG0457	Tetratricopeptide repeat
C5O78_04800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_04805	COG0481	GTPase activity
C5O78_04820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_04825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_04825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_04825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_04830	COG1105	Belongs to the carbohydrate kinase PfkB family
C5O78_04835	COG1349	DNA-binding transcription factor activity
C5O78_04840	COG0450	alkyl hydroperoxide reductase
C5O78_04860	COG1472	Belongs to the glycosyl hydrolase 3 family
C5O78_04865	COG0492	ferredoxin-NADP+ reductase activity
C5O78_04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5O78_04890	COG0444	Belongs to the ABC transporter superfamily
C5O78_04895	COG4608	Belongs to the ABC transporter superfamily
C5O78_04900	COG1132	(ABC) transporter
C5O78_04905	COG1132	(ABC) transporter
C5O78_04910	COG1132	(ABC) transporter
C5O78_04915	COG1132	(ABC) transporter
C5O78_04925	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5O78_04960	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C5O78_04975	COG2801	Transposase and inactivated derivatives
C5O78_05000	COG0584	glycerophosphoryl diester phosphodiesterase
C5O78_05005	COG3958	Transketolase
C5O78_05010	COG3959	Transketolase, thiamine diphosphate binding domain
C5O78_05030	COG1122	ATPase activity
C5O78_05035	COG1268	BioY protein
C5O78_05050	COG0012	GTP binding
C5O78_05055	COG0205	6-phosphofructokinase activity
C5O78_05085	COG1477	protein flavinylation
C5O78_05120	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5O78_05125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5O78_05130	COG0592	DNA-directed DNA polymerase activity
C5O78_05140	COG1687	branched-chain amino acid
C5O78_05145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5O78_05150	COG0116	Belongs to the methyltransferase superfamily
C5O78_05175	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5O78_05185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5O78_05190	COG1129	ABC transporter
C5O78_05200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5O78_05245	COG2226	methyltransferase
C5O78_05270	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O78_05275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5O78_05280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5O78_05280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5O78_05285	COG0739	heme binding
C5O78_05295	COG1132	(ABC) transporter
C5O78_05300	COG1132	(ABC) transporter
C5O78_05305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5O78_05315	COG1187	pseudouridine synthase activity
C5O78_05345	COG1132	(ABC) transporter
C5O78_05350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5O78_05370	COG3706	GGDEF domain
C5O78_05385	COG1413	lyase activity
C5O78_05395	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_05400	COG0673	inositol 2-dehydrogenase activity
C5O78_05405	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_05415	COG1879	ABC-type sugar transport system periplasmic component
C5O78_05470	COG2610	gluconate transmembrane transporter activity
C5O78_05475	COG1929	Belongs to the glycerate kinase type-1 family
C5O78_05485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5O78_05490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_05505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5O78_05565	COG0110	maltose O-acetyltransferase activity
C5O78_05580	COG3579	cysteine-type endopeptidase activity
C5O78_05595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5O78_05615	COG2770	Histidine kinase
C5O78_05615	COG3437	response regulator, receiver
C5O78_05620	COG1214	PFAM Peptidase M22, glycoprotease
C5O78_05625	COG0802	atpase or kinase
C5O78_05630	COG0322	excinuclease ABC activity
C5O78_05660	COG2885	chlorophyll binding
C5O78_05675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5O78_05680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5O78_05690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5O78_05690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5O78_05715	COG0564	pseudouridine synthase activity
C5O78_05730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5O78_05740	COG0488	(ABC) transporter
C5O78_05740	COG0488	(ABC) transporter
C5O78_05750	COG1573	uracil-dna glycosylase
C5O78_05755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5O78_05760	COG1086	Polysaccharide biosynthesis protein
C5O78_05770	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5O78_05785	COG1136	(ABC) transporter
C5O78_05800	COG0552	protein localization to endoplasmic reticulum
C5O78_05835	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5O78_05840	COG3457	Alanine racemase
C5O78_05845	COG0626	cystathionine gamma-synthase activity
C5O78_05885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5O78_05905	COG1473	amidohydrolase
C5O78_05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_05915	COG1121	(ABC) transporter
C5O78_05920	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5O78_05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O78_05935	COG2604	Protein of unknown function DUF115
C5O78_05945	COG1592	Rubrerythrin
C5O78_05975	COG1760	l-serine dehydratase
C5O78_05980	COG1760	l-serine dehydratase
C5O78_05985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C5O78_06255	COG1335	isochorismatase
C5O78_06260	COG3142	Participates in the control of copper homeostasis
C5O78_06270	COG4988	ABC transporter
C5O78_06275	COG1132	(ABC) transporter
C5O78_06280	COG1137	ATPase activity
C5O78_06320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5O78_06335	COG0701	Predicted permease
C5O78_06360	COG1131	(ABC) transporter
C5O78_06365	COG1028	Short-chain dehydrogenase reductase Sdr
C5O78_06380	COG0154	amidase activity
C5O78_06385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5O78_06390	COG0124	histidyl-tRNA synthetase
C5O78_06400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5O78_06405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5O78_06410	COG0579	oxidoreductase
C5O78_06425	COG0728	peptidoglycan biosynthetic process
C5O78_06430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_06570	COG5002	protein histidine kinase activity
C5O78_06570	COG5001	Diguanylate cyclase
C5O78_06575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5O78_06575	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C5O78_06585	COG3118	belongs to the thioredoxin family
C5O78_06590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5O78_06600	COG1516	flagellar protein fliS
C5O78_06605	COG0840	transmembrane signaling receptor activity
C5O78_06625	COG1879	ABC-type sugar transport system periplasmic component
C5O78_06630	COG1129	ABC transporter
C5O78_06635	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_06640	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_06680	COG0719	Fe-S assembly protein
C5O78_06685	COG0719	Fe-S assembly protein
C5O78_06690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5O78_06695	COG0822	iron-sulfur transferase activity
C5O78_06720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5O78_06725	COG0670	Belongs to the BI1 family
C5O78_06735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5O78_06740	COG2801	Transposase and inactivated derivatives
C5O78_06760	COG1366	Belongs to the anti-sigma-factor antagonist family
C5O78_06775	COG0714	Associated with various cellular activities
C5O78_06790	COG0569	domain protein
C5O78_06795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5O78_06800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5O78_06805	COG3876	Protein conserved in bacteria
C5O78_06855	COG3039	Transposase
C5O78_06860	COG0840	transmembrane signaling receptor activity
C5O78_06875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5O78_06890	COG1252	NADH dehydrogenase
C5O78_06900	COG1960	acyl-CoA dehydrogenase activity
C5O78_06905	COG2086	electron transfer activity
C5O78_06910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5O78_06940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5O78_06945	COG1480	7TM receptor with intracellular HD hydrolase
C5O78_06950	COG1702	phosphate starvation-inducible protein PhoH
C5O78_06960	COG0018	arginyl-trna synthetase
C5O78_06970	COG0419	ATPase involved in DNA repair
C5O78_06975	COG0420	3'-5' exonuclease activity
C5O78_06980	COG0840	transmembrane signaling receptor activity
C5O78_07035	COG0571	ribonuclease III activity
C5O78_07040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5O78_07045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5O78_07055	COG0563	adenylate kinase activity
C5O78_07110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5O78_07150	COG0531	amino acid
C5O78_07165	COG0740	serine-type endopeptidase activity
C5O78_07170	COG0543	2 iron, 2 sulfur cluster binding
C5O78_07175	COG0493	'glutamate synthase
C5O78_07190	COG2197	response regulator
C5O78_07220	COG0733	neurotransmitter:sodium symporter activity
C5O78_07225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5O78_07235	COG0765	amino acid transport
C5O78_07250	COG1924	4 iron, 4 sulfur cluster binding
C5O78_07260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5O78_07265	COG0564	pseudouridine synthase activity
C5O78_07270	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O78_07275	COG4555	ABC transporter
C5O78_07295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5O78_07305	COG0731	radical SAM domain protein
C5O78_07315	COG0423	glycine-tRNA ligase activity
C5O78_07320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5O78_07355	COG1271	oxidase subunit
C5O78_07360	COG1294	oxidase, subunit
C5O78_07365	COG4988	ABC transporter
C5O78_07370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5O78_07375	COG0328	RNA-DNA hybrid ribonuclease activity
C5O78_07380	COG4443	Transcriptional Coactivator p15 (PC4)
C5O78_07390	COG0708	Exodeoxyribonuclease III
C5O78_07395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5O78_07400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5O78_07400	COG1263	PTS System
C5O78_07410	COG0183	Belongs to the thiolase family
C5O78_07415	COG1960	acyl-CoA dehydrogenase activity
C5O78_07420	COG0426	domain, Protein
C5O78_07425	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5O78_07430	COG1024	Enoyl-CoA hydratase
C5O78_07435	COG0427	acetyl-CoA hydrolase
C5O78_07450	COG0297	glycogen (starch) synthase activity
C5O78_07455	COG0101	tRNA pseudouridine synthase activity
C5O78_07475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5O78_07480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5O78_07485	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5O78_07500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5O78_07505	COG0456	acetyltransferase
C5O78_07505	COG1214	PFAM Peptidase M22, glycoprotease
C5O78_07510	COG1811	Na channel or pump
C5O78_07525	COG2059	Chromate
C5O78_07550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5O78_07580	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_07590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O78_07615	COG1609	Transcriptional regulator
C5O78_07635	COG0632	four-way junction helicase activity
C5O78_07645	COG0457	Tetratricopeptide repeat
C5O78_07665	COG0789	Transcriptional regulator
C5O78_07690	COG0588	phosphoglycerate mutase activity
C5O78_07695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5O78_07705	COG0149	triose-phosphate isomerase activity
C5O78_07710	COG0126	phosphoglycerate kinase activity
C5O78_07735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O78_07740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5O78_07745	COG0826	peptidase U32
C5O78_07770	COG0433	COG0433 Predicted ATPase
C5O78_07785	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5O78_07800	COG1696	Membrane protein involved in D-alanine export
C5O78_07810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5O78_07815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5O78_07820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5O78_07835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5O78_07840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5O78_07845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5O78_07850	COG1114	Component of the transport system for branched-chain amino acids
C5O78_07855	COG0436	Aminotransferase
C5O78_07860	COG1522	sequence-specific DNA binding
C5O78_07870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5O78_07905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5O78_07925	COG0823	Involved in the tonB-independent uptake of proteins
C5O78_07925	COG1506	peptidase
C5O78_07925	COG4946	Tricorn protease homolog
C5O78_07930	COG0840	transmembrane signaling receptor activity
C5O78_07945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5O78_07960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5O78_07965	COG1469	GTP cyclohydrolase I activity
C5O78_07980	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C5O78_07990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5O78_08005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5O78_08010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5O78_08030	COG3956	TIGRFAM MazG family protein
C5O78_08060	COG0716	FMN binding
C5O78_08070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5O78_08080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5O78_08085	COG0250	Participates in transcription elongation, termination and antitermination
C5O78_08090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5O78_08095	COG0081	regulation of translation
C5O78_08110	COG0085	RNA polymerase activity
C5O78_08120	COG1394	ATPase activity, coupled to movement of substances
C5O78_08135	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5O78_08145	COG0426	domain, Protein
C5O78_08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5O78_08150	COG2304	oxidoreductase activity
C5O78_08165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_08165	COG0574	Belongs to the PEP-utilizing enzyme family
C5O78_08175	COG1131	(ABC) transporter
C5O78_08185	COG0180	Tryptophanyl-tRNA synthetase
C5O78_08190	COG3735	TraB family
C5O78_08195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5O78_08210	COG3700	Belongs to the class B bacterial acid phosphatase family
C5O78_08230	COG2339	peptidase activity
C5O78_08235	COG0151	Belongs to the GarS family
C5O78_08240	COG0138	bifunctional purine biosynthesis protein purh
C5O78_08260	COG1509	lysine 2,3-aminomutase activity
C5O78_08265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_08275	COG1177	transmembrane transport
C5O78_08280	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5O78_08285	COG3842	ATPase activity
C5O78_08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O78_08300	COG0724	RNA recognition motif
C5O78_08310	COG1979	alcohol dehydrogenase
C5O78_08320	COG0791	NLP P60 protein
C5O78_08320	COG1388	LysM domain
C5O78_08325	COG0318	PFAM AMP-dependent synthetase and ligase
C5O78_08335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5O78_08335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5O78_08340	COG0739	heme binding
C5O78_08350	COG0295	cytidine deaminase activity
C5O78_08360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5O78_08380	COG1272	protein, Hemolysin III
C5O78_08570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5O78_08730	COG0564	pseudouridine synthase activity
C5O78_08730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5O78_08750	COG0823	Involved in the tonB-independent uptake of proteins
C5O78_08770	COG5341	Protein conserved in bacteria
C5O78_08775	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5O78_08780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5O78_08810	COG1968	undecaprenyl-diphosphatase activity
C5O78_08815	COG1674	ftsk spoiiie
C5O78_08825	COG0482	sulfurtransferase activity
C5O78_08885	COG0166	Belongs to the GPI family
C5O78_08895	COG4585	Histidine kinase
C5O78_08900	COG2197	response regulator
C5O78_08915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5O78_08940	COG0330	HflC and HflK could
C5O78_08955	COG2084	Dehydrogenase
C5O78_08965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5O78_08970	COG1653	transport
C5O78_08980	COG0395	ABC-type sugar transport system, permease component
C5O78_09010	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C5O78_09015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5O78_09020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5O78_09025	COG1722	exodeoxyribonuclease VII activity
C5O78_09030	COG1966	Carbon starvation protein
C5O78_09035	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C5O78_09060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5O78_09065	COG0534	Mate efflux family protein
C5O78_09070	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O78_09080	COG0549	Belongs to the carbamate kinase family
C5O78_09085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5O78_09090	COG2235	arginine
C5O78_09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_09125	COG1747	RNA polymerase binding
C5O78_09125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5O78_09135	COG2183	response to ionizing radiation
C5O78_09165	COG0488	(ABC) transporter
C5O78_09175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5O78_09180	COG0793	Belongs to the peptidase S41A family
C5O78_09185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5O78_09200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C5O78_09215	COG0673	inositol 2-dehydrogenase activity
C5O78_09230	COG1191	sigma factor activity
C5O78_09235	COG1847	R3H domain protein
C5O78_09260	COG0840	transmembrane signaling receptor activity
C5O78_09285	COG0840	transmembrane signaling receptor activity
C5O78_09380	COG0840	transmembrane signaling receptor activity
C5O78_09390	COG0778	Nitroreductase
C5O78_09455	COG1132	(ABC) transporter
C5O78_09460	COG1132	(ABC) transporter
C5O78_09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5O78_09470	COG1120	ATPase activity
C5O78_09500	COG0785	Cytochrome C biogenesis protein
C5O78_09505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O78_09570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5O78_09575	COG0786	glutamate:sodium symporter activity
C5O78_09590	COG2378	regulation of single-species biofilm formation
C5O78_09635	COG0519	Catalyzes the synthesis of GMP from XMP
C5O78_09645	COG0519	Catalyzes the synthesis of GMP from XMP
C5O78_09730	COG0210	DNA helicase
C5O78_09765	COG2226	methyltransferase
C5O78_09800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5O78_09820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5O78_09835	COG1744	ABC transporter substrate-binding protein PnrA-like
C5O78_09840	COG3845	ABC transporter
C5O78_09845	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5O78_09850	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5O78_09870	COG1346	cytolysis
C5O78_09890	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C5O78_09910	COG0191	fructose-bisphosphate aldolase activity
C5O78_09935	COG4166	transmembrane transport
C5O78_09950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_09970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O78_09975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O78_09980	COG1862	Preprotein translocase
C5O78_09985	COG1639	'signal transduction protein
C5O78_09995	COG4115	mRNA cleavage
C5O78_10025	COG2078	PFAM AMMECR1 domain protein
C5O78_10025	COG3885	ferrous iron binding
C5O78_10035	COG1022	Amp-dependent synthetase and ligase
C5O78_10040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5O78_10045	COG1486	melibiose metabolic process
C5O78_10055	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
C5O78_10060	COG2982	Protein involved in outer membrane biogenesis
C5O78_10065	COG0697	spore germination
C5O78_10075	COG2723	6-phospho-beta-galactosidase activity
C5O78_10080	COG0561	phosphatase activity
C5O78_10085	COG1263	PTS System
C5O78_10085	COG2190	(PTS) system
C5O78_10085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5O78_10090	COG2188	Transcriptional regulator
C5O78_10100	COG4786	Flagellar basal body rod
C5O78_10115	COG0301	tRNA thio-modification
C5O78_10120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5O78_10145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5O78_10155	COG1704	LemA family
C5O78_10160	COG2502	aspartate--ammonia ligase
C5O78_10195	COG0666	response to abiotic stimulus
C5O78_10220	COG0739	heme binding
C5O78_10240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5O78_10245	COG2070	2-Nitropropane dioxygenase
C5O78_10250	COG3976	FMN-binding domain protein
C5O78_10250	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C5O78_10275	COG1136	(ABC) transporter
C5O78_10290	COG0577	efflux transmembrane transporter activity
C5O78_10290	COG1136	(ABC) transporter
C5O78_10305	COG3470	protein probably involved in high-affinity Fe2 transport
C5O78_10310	COG0672	)-iron permease
C5O78_10320	COG1136	(ABC) transporter
C5O78_10345	COG1640	4-alpha-glucanotransferase
C5O78_10375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5O78_10380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5O78_10390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5O78_10405	COG1366	Belongs to the anti-sigma-factor antagonist family
C5O78_10450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5O78_10480	COG0826	peptidase U32
C5O78_10500	COG0542	response to heat
C5O78_10520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5O78_10535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5O78_10550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5O78_10610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5O78_10620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5O78_10625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5O78_10635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5O78_10640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5O78_10650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_10660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_10670	COG5016	pyruvate
C5O78_10670	COG0511	ligase activity, forming carbon-carbon bonds
C5O78_10675	COG3630	sodium ion export across plasma membrane
C5O78_10695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5O78_10700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5O78_10705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5O78_10715	COG0300	oxidoreductase activity
C5O78_10730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_10760	COG2003	Belongs to the UPF0758 family
C5O78_10780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5O78_10805	COG2801	Transposase and inactivated derivatives
C5O78_10945	COG0228	four-way junction DNA binding
C5O78_10950	COG1837	Belongs to the UPF0109 family
C5O78_10955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5O78_10960	COG0336	Belongs to the RNA methyltransferase TrmD family
C5O78_10965	COG0335	large ribosomal subunit rRNA binding
C5O78_10975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_11015	COG0210	DNA helicase
C5O78_11020	COG0733	neurotransmitter:sodium symporter activity
C5O78_11030	COG0561	phosphatase activity
C5O78_11040	COG3681	Belongs to the UPF0597 family
C5O78_11050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5O78_11060	COG0142	geranyltranstransferase activity
C5O78_11065	COG1609	Transcriptional regulator
C5O78_11070	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5O78_11080	COG0395	ABC-type sugar transport system, permease component
C5O78_11085	COG4209	transmembrane transport
C5O78_11095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5O78_11100	COG2986	histidine ammonia-lyase
C5O78_11105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5O78_11105	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5O78_11105	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5O78_11105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5O78_11115	COG0626	cystathionine gamma-synthase activity
C5O78_11120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5O78_11125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5O78_11135	COG1132	(ABC) transporter
C5O78_11140	COG0653	protein targeting
C5O78_11145	COG2801	Transposase and inactivated derivatives
C5O78_11155	COG0556	nucleotide-excision repair
C5O78_11175	COG1102	Psort location Cytoplasmic, score
C5O78_11190	COG0840	transmembrane signaling receptor activity
C5O78_11200	COG2801	Transposase and inactivated derivatives
C5O78_11210	COG0778	Nitroreductase
C5O78_11215	COG1104	cysteine desulfurase activity
C5O78_11230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_11230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_11270	COG1067	ATP-dependent peptidase activity
C5O78_11295	COG0737	Belongs to the 5'-nucleotidase family
C5O78_11300	COG3842	ATPase activity
C5O78_11310	COG0656	L-ascorbic acid biosynthetic process
C5O78_11320	COG1802	Transcriptional regulator
C5O78_11340	COG1368	sulfuric ester hydrolase activity
C5O78_11345	COG1368	sulfuric ester hydrolase activity
C5O78_11375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5O78_11385	COG0343	queuine tRNA-ribosyltransferase activity
C5O78_11390	COG0779	Required for maturation of 30S ribosomal subunits
C5O78_11400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5O78_11410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5O78_11420	COG0196	riboflavin kinase activity
C5O78_11430	COG1185	polyribonucleotide nucleotidyltransferase activity
C5O78_11435	COG0756	dUTP diphosphatase activity
C5O78_11450	COG1739	Uncharacterized protein family UPF0029
C5O78_11455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5O78_11465	COG1070	Carbohydrate kinase
C5O78_11480	COG2801	Transposase and inactivated derivatives
C5O78_11485	COG2801	Transposase and inactivated derivatives
C5O78_11495	COG2095	MarC family integral membrane protein
C5O78_11505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5O78_11510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5O78_11520	COG0737	Belongs to the 5'-nucleotidase family
C5O78_11530	COG0525	valine-tRNA ligase activity
C5O78_11550	COG1132	(ABC) transporter
C5O78_11555	COG1132	(ABC) transporter
C5O78_11580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5O78_11590	COG1132	(ABC) transporter
C5O78_11595	COG2375	cellular response to nickel ion
C5O78_11595	COG1132	(ABC) transporter
C5O78_11600	COG1309	transcriptional regulator
C5O78_11605	COG0516	GMP reductase activity
C5O78_11605	COG0517	IMP dehydrogenase activity
C5O78_11620	COG0840	transmembrane signaling receptor activity
C5O78_11645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5O78_11675	COG0517	IMP dehydrogenase activity
C5O78_11685	COG0326	Molecular chaperone. Has ATPase activity
C5O78_11705	COG0840	transmembrane signaling receptor activity
C5O78_11710	COG0017	Asparaginyl-tRNA synthetase
C5O78_11730	COG2801	Transposase and inactivated derivatives
C5O78_11735	COG1744	ABC transporter substrate-binding protein PnrA-like
C5O78_11740	COG3845	ABC transporter
C5O78_11745	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5O78_11750	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5O78_11755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5O78_11785	COG0656	L-ascorbic acid biosynthetic process
C5O78_11820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_11830	COG2801	Transposase and inactivated derivatives
C5O78_11855	COG3385	transposase activity
C5O78_11865	COG3177	Filamentation induced by cAMP protein fic
C5O78_11875	COG2217	Heavy metal translocating P-type atpase
C5O78_11885	COG0640	Transcriptional regulator
C5O78_11930	COG0395	ABC-type sugar transport system, permease component
C5O78_11935	COG4209	transmembrane transport
C5O78_11940	COG1040	competence protein
C5O78_11955	COG1388	LysM domain
C5O78_11955	COG0741	lytic transglycosylase activity
C5O78_11965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5O78_11975	COG1475	DNA binding
C5O78_11980	COG1192	Involved in chromosome partitioning
C5O78_11985	COG4953	penicillin-binding protein 1C
C5O78_11990	COG2373	Large extracellular alpha-helical protein
C5O78_11995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5O78_12010	COG2089	acid synthase
C5O78_12020	COG0495	leucyl-tRNA aminoacylation
C5O78_12025	COG0351	phosphomethylpyrimidine kinase
C5O78_12035	COG0739	heme binding
C5O78_12045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5O78_12050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5O78_12055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5O78_12080	COG0739	heme binding
C5O78_12095	COG0517	IMP dehydrogenase activity
C5O78_12095	COG1227	inorganic diphosphatase activity
C5O78_12105	COG0768	penicillin binding
C5O78_12110	COG2604	Protein of unknown function DUF115
C5O78_12140	COG5377	YqaJ viral recombinase family
C5O78_12160	COG3723	Recombinational DNA repair protein, rece pathway
C5O78_12180	COG2376	Dihydroxyacetone kinase
C5O78_12200	COG0557	exoribonuclease II activity
C5O78_12220	COG1129	ABC transporter
C5O78_12240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_12260	COG1234	tRNA 3'-trailer cleavage
C5O78_12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_12300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5O78_12310	COG0504	CTP synthase activity
C5O78_12315	COG1757	Na H antiporter
C5O78_12330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5O78_12340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_12345	COG0765	amino acid transport
C5O78_12350	COG1126	abc transporter atp-binding protein
C5O78_12365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5O78_12380	COG1175	transmembrane transport
C5O78_12390	COG0330	HflC and HflK could
C5O78_12395	COG0330	HflC and HflK could
C5O78_12415	COG1785	Belongs to the alkaline phosphatase family
C5O78_12440	COG1136	(ABC) transporter
C5O78_12460	COG0037	tRNA processing
C5O78_12470	COG1309	transcriptional regulator
C5O78_12480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5O78_12490	COG1047	Peptidyl-prolyl cis-trans
C5O78_12500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5O78_12505	COG3951	Flagellar rod assembly protein muramidase FlgJ
C5O78_12515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5O78_12530	COG1193	negative regulation of DNA recombination
C5O78_12535	COG1162	GTPase activity
C5O78_12555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O78_12580	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5O78_12580	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5O78_12580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5O78_12580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5O78_12600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5O78_12600	COG1918	ferrous iron import across plasma membrane
C5O78_12650	COG2204	response regulator
C5O78_12655	COG3852	Histidine kinase
C5O78_12660	COG0470	DNA polymerase III
C5O78_12665	COG1286	toxin biosynthetic process
C5O78_12670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5O78_12695	COG1692	metallophosphoesterase
C5O78_12705	COG0142	geranyltranstransferase activity
C5O78_12720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5O78_12725	COG0205	6-phosphofructokinase activity
C5O78_12730	COG2801	Transposase and inactivated derivatives
C5O78_12755	COG2239	Acts as a magnesium transporter
C5O78_12760	COG0460	homoserine dehydrogenase
C5O78_12765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5O78_12770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C5O78_12785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5O78_12805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5O78_12810	COG4608	Belongs to the ABC transporter superfamily
C5O78_12815	COG0444	Belongs to the ABC transporter superfamily
C5O78_12825	COG0601	transmembrane transport
C5O78_12835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O78_12840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5O78_12840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5O78_12855	COG0523	cobalamin synthesis protein
C5O78_12865	COG1349	DNA-binding transcription factor activity
C5O78_12875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_12880	COG0191	fructose-bisphosphate aldolase activity
C5O78_12885	COG0673	inositol 2-dehydrogenase activity
C5O78_12890	COG1228	amidohydrolase
C5O78_12930	COG0432	Pfam Uncharacterised protein family UPF0047
C5O78_12940	COG0513	Belongs to the DEAD box helicase family
C5O78_12960	COG1131	(ABC) transporter
C5O78_12970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_12990	COG1129	ABC transporter
C5O78_12995	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_13005	COG0617	tRNA 3'-terminal CCA addition
C5O78_13010	COG0668	transmembrane transport
C5O78_13050	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5O78_13060	COG0084	hydrolase, TatD family'
C5O78_13065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5O78_13070	COG3118	belongs to the thioredoxin family
C5O78_13075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5O78_13095	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5O78_13110	COG2357	RelA SpoT domain protein
C5O78_13115	COG0268	Binds directly to 16S ribosomal RNA
C5O78_13120	COG0776	regulation of translation
C5O78_13130	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5O78_13140	COG1546	Belongs to the CinA family
C5O78_13140	COG1058	Belongs to the CinA family
C5O78_13145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5O78_13150	COG0254	rRNA binding
C5O78_13180	COG0395	ABC-type sugar transport system, permease component
C5O78_13185	COG1175	transmembrane transport
C5O78_13200	COG0395	ABC-type sugar transport system, permease component
C5O78_13220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5O78_13225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O78_13225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O78_13260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O78_13260	COG0515	serine threonine protein kinase
C5O78_13265	COG0811	peptide transport
C5O78_13270	COG0848	biopolymer transport protein
C5O78_13295	COG0203	ribosomal protein L17
C5O78_13300	COG0202	RNA polymerase activity
C5O78_13305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5O78_13315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5O78_13325	COG0200	Binds to the 23S rRNA
C5O78_13330	COG1841	ribosomal large subunit assembly
C5O78_13340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5O78_13345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5O78_13350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5O78_13360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5O78_13375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5O78_13380	COG0255	Belongs to the universal ribosomal protein uL29 family
C5O78_13390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5O78_13395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5O78_13405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5O78_13410	COG0089	rRNA binding
C5O78_13415	COG0088	Forms part of the polypeptide exit tunnel
C5O78_13420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5O78_13425	COG0051	transcription antitermination factor activity, RNA binding
C5O78_13430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5O78_13440	COG1652	LysM domain
C5O78_13440	COG2823	Periplasmic or secreted lipoprotein
C5O78_13450	COG2033	superoxide reductase activity
C5O78_13455	COG1078	dGTPase activity
C5O78_13485	COG1774	PSP1 C-terminal conserved region
C5O78_13500	COG0739	heme binding
C5O78_13510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5O78_13520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5O78_13540	COG0710	3-dehydroquinate dehydratase activity
C5O78_13540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5O78_13545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5O78_13550	COG0237	dephospho-CoA kinase activity
C5O78_13565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5O78_13570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_13585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5O78_13595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C5O78_13605	COG1671	Belongs to the UPF0178 family
C5O78_13610	COG3437	response regulator, receiver
C5O78_13620	COG1419	protein localization to endoplasmic reticulum
C5O78_13625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_13630	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_13635	COG1684	flagellar biosynthetic protein fliR
C5O78_13640	COG1987	bacterial-type flagellum assembly
C5O78_13645	COG1338	Plays a role in the flagellum-specific transport system
C5O78_13655	COG1776	CheC inhibitor of MCP methylation
C5O78_13655	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_13660	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_13665	COG1580	Controls the rotational direction of flagella during chemotaxis
C5O78_13670	COG1360	Flagellar Motor Protein
C5O78_13690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5O78_13715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C5O78_13725	COG5278	phosphoserine phosphatase activity
C5O78_13725	COG0840	transmembrane signaling receptor activity
C5O78_13740	COG1164	Oligoendopeptidase f
C5O78_13745	COG1690	Belongs to the RtcB family
C5O78_13750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_13750	COG2213	PTS system mannitol-specific
C5O78_13755	COG1349	DNA-binding transcription factor activity
C5O78_13760	COG1063	alcohol dehydrogenase
C5O78_13770	COG0235	Class ii aldolase
C5O78_13775	COG0058	SHG alpha-glucan phosphorylase activity
C5O78_13785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5O78_13805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O78_13805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O78_13805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5O78_13830	COG1151	hydroxylamine reductase activity
C5O78_13880	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_13885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_13930	COG3052	prosthetic group binding
C5O78_13975	COG1129	ABC transporter
C5O78_14005	COG2226	methyltransferase
C5O78_14040	COG3177	Filamentation induced by cAMP protein fic
C5O78_14200	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_14200	COG1454	alcohol dehydrogenase
C5O78_14210	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C5O78_14215	COG0442	prolyl-tRNA aminoacylation
C5O78_14230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5O78_14245	COG0628	permease
C5O78_14250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5O78_14260	COG1312	Catalyzes the dehydration of D-mannonate
C5O78_14265	COG0246	Mannitol dehydrogenase
C5O78_14285	COG1904	glucuronate isomerase
C5O78_14290	COG3250	beta-galactosidase activity
C5O78_14295	COG2211	Major facilitator Superfamily
C5O78_14310	COG1349	DNA-binding transcription factor activity