locus-tag	class	description
TREPR_0001	ENOG4105EXC	Acyl-transferase
TREPR_0003	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
TREPR_0007	ENOG4105D3Q	Sugar transferase
TREPR_0008	ENOG4105DMT	epimerase dehydratase
TREPR_0009	ENOG4108RT7	Glycosyl transferase, family 2
TREPR_0020	ENOG4107S6X	Glycosyl transferase, family 2
TREPR_0033	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
TREPR_0035	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TREPR_0039	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
TREPR_0040	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TREPR_0049	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TREPR_0052	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_0060	ENOG4105CN1	protease
TREPR_0072	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
TREPR_0081	ENOG4105D4X	repressor
TREPR_0085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0087	ENOG4105D81	ABC transporter, permease
TREPR_0088	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
TREPR_0106	ENOG41081GK	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase
TREPR_0109	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TREPR_0119	ENOG4107QI1	Mate efflux family protein
TREPR_0120	ENOG4105C3R	Methionine synthase
TREPR_0123	ENOG4105CFP	Peptidase U32
TREPR_0125	ENOG4108SP1	single-stranded DNA-binding protein
TREPR_0129	ENOG41076HS	cation diffusion facilitator family transporter
TREPR_0130	ENOG4105C0H	protease
TREPR_0131	ENOG4105E98	transcriptional regulator DeoR family
TREPR_0132	ENOG4105N2W	Transcriptional regulator
TREPR_0133	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TREPR_0134	ENOG4105CPQ	Dehydrogenase
TREPR_0136	ENOG4105C22	threonyL-tRNA synthetase
TREPR_0143	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TREPR_0144	ENOG4105KXX	peptidase s58 dmpa
TREPR_0148	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
TREPR_0149	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TREPR_0150	ENOG41069P5	Protein slyX homolog
TREPR_0157	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TREPR_0161	ENOG4105BZU	Histidine kinase
TREPR_0162	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TREPR_0165	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TREPR_0170	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
TREPR_0173	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
TREPR_0175	ENOG4108IQE	Amp-dependent synthetase and ligase
TREPR_0178	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TREPR_0183	ENOG4105BZU	Histidine kinase
TREPR_0184	ENOG410620I	Diguanylate cyclase
TREPR_0195	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TREPR_0203	ENOG4105K64	Glycosyl transferase, family 2
TREPR_0213	ENOG4105XMH	SpoVT AbrB domain protein
TREPR_0218	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TREPR_0219	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TREPR_0223	ENOG4108IUJ	4-alpha-glucanotransferase
TREPR_0226	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TREPR_0227	ENOG4107QTF	adenylosuccinate lyase
TREPR_0230	ENOG4107QIV	Cytochrome c biogenesis protein
TREPR_0233	ENOG4108SSC	basic membrane
TREPR_0234	ENOG4105C2J	ABC transporter
TREPR_0240	ENOG4107S1W	4-alpha-glucanotransferase
TREPR_0245	ENOG4105D06	uba thif-type nad fad binding protein
TREPR_0249	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
TREPR_0250	ENOG4105C11	sulfate adenylyltransferase), subunit 2
TREPR_0252	ENOG4108IJ6	ABC transporter
TREPR_0254	ENOG4108I5D	sulfate abc transporter
TREPR_0255	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
TREPR_0256	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TREPR_0259	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TREPR_0262	ENOG4105D52	delta-aminolevulinic acid dehydratase
TREPR_0264	ENOG4105D98	threonine synthase
TREPR_0265	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_0266	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
TREPR_0267	ENOG4105CNN	ABC, transporter
TREPR_0268	ENOG4105C2J	ABC transporter
TREPR_0270	ENOG4108TSD	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
TREPR_0274	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TREPR_0275	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
TREPR_0277	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TREPR_0279	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TREPR_0280	ENOG4105BZU	Histidine kinase
TREPR_0281	ENOG4105BZU	Histidine kinase
TREPR_0282	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TREPR_0284	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0288	ENOG4108UIN	ybak prolyl-trna synthetase associated region
TREPR_0293	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
TREPR_0296	ENOG4105I03	Flagellin
TREPR_0298	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_0302	ENOG4105CPC	Aldo Keto reductase
TREPR_0303	ENOG4105CY0	Metallo-Beta-Lactamase
TREPR_0305	ENOG4108R3D	Electron transport complex
TREPR_0306	ENOG4105DGN	Electron transport complex
TREPR_0307	ENOG4105DZB	Electron transport complex
TREPR_0308	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
TREPR_0309	ENOG4105D6A	Electron transport complex
TREPR_0310	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
TREPR_0311	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TREPR_0312	ENOG4105CFG	Acts as a chaperone (By similarity)
TREPR_0313	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TREPR_0314	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TREPR_0318	ENOG4105E4P	ATPase (AAA
TREPR_0323	ENOG4105XMH	SpoVT AbrB domain protein
TREPR_0333	ENOG4107TXM	Nad-dependent epimerase dehydratase
TREPR_0334	ENOG4108HHA	Transketolase
TREPR_0336	ENOG4107XGZ	Hydrolase
TREPR_0340	ENOG4105CAQ	asparagine synthetase
TREPR_0342	ENOG4108KMV	Glycosyl transferase (Group 1
TREPR_0344	ENOG4108IAJ	Nad-dependent epimerase dehydratase
TREPR_0345	ENOG4107QQG	Dehydrogenase
TREPR_0353	ENOG4105D3Q	Sugar transferase
TREPR_0357	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
TREPR_0367	ENOG4105CPF	Cell wall formation (By similarity)
TREPR_0369	ENOG4108MXF	Alpha Beta Hydrolase
TREPR_0370	ENOG4108RCM	Nitroreductase
TREPR_0371	ENOG4107RAN	Peptidase, M16
TREPR_0372	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TREPR_0373	ENOG4105CVG	Homoserine O-transsuccinylase
TREPR_0375	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TREPR_0380	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
TREPR_0382	ENOG4105CRQ	synthase (Component I)
TREPR_0383	ENOG4105DDQ	anthranilate synthase
TREPR_0384	ENOG4108I0Q	anthranilate phosphoribosyltransferase
TREPR_0385	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TREPR_0387	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TREPR_0388	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TREPR_0391	ENOG4105QUH	Domain of unknown function (DUF2088)
TREPR_0393	ENOG4105C6K	Malic enzyme
TREPR_0395	ENOG4105BZA	Phosphoglycerate kinase
TREPR_0396	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
TREPR_0397	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
TREPR_0399	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
TREPR_0401	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_0402	ENOG4105C2J	ABC transporter
TREPR_0403	ENOG4105CNN	ABC, transporter
TREPR_0404	ENOG4107R5G	Periplasmic binding protein LacI transcriptional regulator
TREPR_0405	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_0406	ENOG4105CV1	Transketolase (EC 2.2.1.1)
TREPR_0407	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TREPR_0408	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
TREPR_0409	ENOG4105K5B	UPF0225 protein
TREPR_0410	ENOG4105C0D	helicase
TREPR_0417	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
TREPR_0421	ENOG4105D98	threonine synthase
TREPR_0423	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
TREPR_0424	ENOG4105CE7	Amidase, hydantoinase carbamoylase family
TREPR_0425	ENOG4107SJI	Dehydrogenase
TREPR_0427	ENOG4107XKF	NMT1 THI5 Like Domain Protein
TREPR_0428	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
TREPR_0429	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
TREPR_0433	ENOG4105C32	Amino acid ABC transporter (Permease)
TREPR_0435	ENOG4105C0Z	ABC transporter
TREPR_0436	ENOG4108IV0	ABC, transporter
TREPR_0440	ENOG4105C0Z	ABC transporter
TREPR_0441	ENOG4108IV0	ABC, transporter
TREPR_0442	ENOG4105CNN	ABC, transporter
TREPR_0446	ENOG4105EBR	Carboxylesterase
TREPR_0447	ENOG4105C6E	dna polymerase iii
TREPR_0448	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
TREPR_0449	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TREPR_0450	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
TREPR_0451	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_0452	ENOG4105F8V	Hydrolase, tatD family
TREPR_0453	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TREPR_0454	ENOG4105BZU	Histidine kinase
TREPR_0456	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TREPR_0460	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TREPR_0463	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
TREPR_0464	ENOG4105KZ7	phosphocarrier protein hpr
TREPR_0465	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TREPR_0466	ENOG4105VCP	PTS System
TREPR_0467	ENOG4105VZJ	PTS System
TREPR_0468	ENOG4105CK1	PTS System
TREPR_0469	ENOG4105M2Z	protein tyrosine serine phosphatase
TREPR_0470	ENOG4105CS2	ec 3.2.1.21
TREPR_0471	ENOG4107VKM	6-phosphogluconolactonase
TREPR_0472	ENOG4107QY8	reductase
TREPR_0473	ENOG4105DC7	peptidase M24
TREPR_0476	ENOG4108JQ7	(ABC) transporter
TREPR_0477	ENOG4105C3U	ABC transporter
TREPR_0478	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_0483	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
TREPR_0489	ENOG4105DM4	PTS System
TREPR_0490	ENOG4105D7N	magnesium and cobalt transport protein CorA
TREPR_0491	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TREPR_0492	ENOG4105DSF	transport protein
TREPR_0493	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_0494	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_0495	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_0497	ENOG41067SE	Tetr family transcriptional regulator
TREPR_0498	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
TREPR_0499	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
TREPR_0502	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
TREPR_0503	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TREPR_0504	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TREPR_0505	ENOG41084M4	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
TREPR_0506	ENOG4105VG0	50S ribosomal protein l34
TREPR_0510	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
TREPR_0512	ENOG4105WPN	DNA integration recombination invertion protein
TREPR_0513	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TREPR_0516	ENOG4107PPM	cobalt chelatase
TREPR_0518	ENOG4105D05	Receptor
TREPR_0520	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
TREPR_0521	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TREPR_0522	ENOG4108P62	biosynthesis protein (CbiG)
TREPR_0523	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TREPR_0525	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
TREPR_0526	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TREPR_0527	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TREPR_0528	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TREPR_0529	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TREPR_0530	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TREPR_0532	ENOG4105EHG	Permease protein
TREPR_0533	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0534	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TREPR_0537	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
TREPR_0539	ENOG4105EHG	Permease protein
TREPR_0540	ENOG4105E0A	ABC, transporter
TREPR_0541	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
TREPR_0543	ENOG4108YZT	Adenosylcobinamide kinase
TREPR_0545	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
TREPR_0546	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TREPR_0553	ENOG4105CX6	glutaminyL-tRNA synthetase
TREPR_0556	ENOG4105C5H	ABC transporter
TREPR_0560	ENOG4105CMR	udp-glucose 4-epimerase
TREPR_0561	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TREPR_0562	ENOG4108UW5	maltose o-acetyltransferase
TREPR_0566	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
TREPR_0567	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0568	ENOG4105F38	ABC transporter, permease
TREPR_0569	ENOG4105D38	putrescine abc transporter
TREPR_0570	ENOG4107RUE	extracellular solute-binding protein family 1
TREPR_0572	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TREPR_0573	ENOG4105CUZ	uba thif-type nad fad binding protein
TREPR_0581	ENOG4105EB3	Histidine kinase
TREPR_0583	ENOG410681U	heavy metal transport detoxification protein
TREPR_0584	ENOG4105C59	p-type ATPase
TREPR_0587	ENOG4107UEK	pfkb domain protein
TREPR_0588	ENOG4108UHU	Aldolase
TREPR_0589	ENOG4105D2H	Uronic isomerase
TREPR_0590	ENOG4105DEI	Mannitol dehydrogenase
TREPR_0591	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
TREPR_0592	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TREPR_0595	ENOG4107XBN	GntR Family Transcriptional Regulator
TREPR_0596	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TREPR_0598	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TREPR_0599	ENOG4105VEM	Conserved domain protein
TREPR_0605	ENOG4105XMH	SpoVT AbrB domain protein
TREPR_0606	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
TREPR_0608	ENOG4105CTQ	phosphohexokinase
TREPR_0612	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TREPR_0614	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TREPR_0616	ENOG4105BZU	Histidine kinase
TREPR_0625	ENOG4108Z4K	mutator MutT protein
TREPR_0627	ENOG4105CE1	Ferrous iron transport protein b
TREPR_0629	ENOG4105C28	cystathionine
TREPR_0630	ENOG4105C28	cystathionine
TREPR_0631	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
TREPR_0634	ENOG4105CHM	Aminotransferase
TREPR_0638	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TREPR_0639	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TREPR_0640	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TREPR_0641	ENOG4105DCG	PHP domain protein
TREPR_0648	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TREPR_0650	ENOG4105UYK	outer membrane protein a
TREPR_0651	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_0655	ENOG4105CMG	Carbohydrate kinase
TREPR_0658	ENOG4107RCV	ABC transporter, permease
TREPR_0659	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0660	ENOG4105ECY	inositol monophosphatase
TREPR_0663	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TREPR_0665	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TREPR_0667	ENOG4107MD5	glycoside hydrolase, family
TREPR_0668	ENOG4105C9X	ppx gppa phosphatase
TREPR_0669	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
TREPR_0670	ENOG4105DR4	Methyltransferase
TREPR_0673	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_0675	ENOG4108JQ7	(ABC) transporter
TREPR_0683	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TREPR_0684	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TREPR_0685	ENOG4105ES5	Histidine kinase
TREPR_0686	ENOG4105KZ7	phosphocarrier protein hpr
TREPR_0687	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
TREPR_0688	ENOG41082AN	stage II sporulation protein
TREPR_0692	ENOG4105DCI	Phosphohydrolase
TREPR_0698	ENOG4105BZU	Histidine kinase
TREPR_0699	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_0700	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
TREPR_0703	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TREPR_0704	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_0705	ENOG4105C3U	ABC transporter
TREPR_0706	ENOG4108JQ7	(ABC) transporter
TREPR_0707	ENOG4105DEF	Extracellular solute-binding protein, family 5
TREPR_0711	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TREPR_0714	ENOG4105E4C	Lytic transglycosylase catalytic
TREPR_0716	ENOG4105EAH	synthase
TREPR_0717	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
TREPR_0720	ENOG4105CV8	reductase
TREPR_0722	ENOG4105EAB	amino acid AbC transporter
TREPR_0723	ENOG4105E5Q	amino acid AbC transporter
TREPR_0726	ENOG4105BZ1	(ABC) transporter
TREPR_0727	ENOG4108HWV	)-transporter
TREPR_0728	ENOG4105C2J	ABC transporter
TREPR_0729	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
TREPR_0730	ENOG4107RFY	SbcCD D subunit
TREPR_0731	ENOG4105EYH	Exonuclease
TREPR_0733	ENOG4105UQX	Mate efflux family protein
TREPR_0734	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TREPR_0735	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TREPR_0738	ENOG4108J1Q	
TREPR_0744	ENOG4108Z40	Transcriptional regulator
TREPR_0747	ENOG4106MP8	UPF0754 membrane protein
TREPR_0749	ENOG4105C4R	Atp-dependent dna helicase
TREPR_0755	ENOG4108Q52	Methyltransferase cognate corrinoid protein
TREPR_0758	ENOG4105DI5	UPF0365 protein
TREPR_0764	ENOG4105VFU	Rna-binding protein
TREPR_0765	ENOG4108HU6	Metal dependent phosphohydrolase
TREPR_0767	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TREPR_0768	ENOG410835P	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TREPR_0773	ENOG4105YES	addiction module antidote protein
TREPR_0774	ENOG4105VUH	addiction module killer protein
TREPR_0776	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TREPR_0779	ENOG4105M7K	Involved in the transcription termination process (By similarity)
TREPR_0781	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TREPR_0791	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
TREPR_0796	ENOG4105CY3	ABC transporter, permease
TREPR_0797	ENOG4105KMT	branched-chain amino acid
TREPR_0798	ENOG4108UMN	azlc family
TREPR_0799	ENOG4105NBF	ammecr1 domain protein
TREPR_0800	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
TREPR_0801	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TREPR_0808	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
TREPR_0817	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
TREPR_0819	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TREPR_0825	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TREPR_0826	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_0829	ENOG4105DFM	M18 family aminopeptidase
TREPR_0830	ENOG4107RRN	ABC transporter substrate-binding protein
TREPR_0831	ENOG4105CH2	amidohydrolase
TREPR_0832	ENOG4108UMI	ABC transporter, permease
TREPR_0833	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_0836	ENOG4105C28	cystathionine
TREPR_0839	ENOG4108V2V	5 nucleotidase deoxy cytosolic type C
TREPR_0843	ENOG4105KVH	Transcriptional regulator
TREPR_0848	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
TREPR_0850	ENOG41084P6	50S ribosomal protein l28
TREPR_0851	ENOG4105PNM	synthesis protein
TREPR_0854	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TREPR_0855	ENOG4105BZU	Histidine kinase
TREPR_0859	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TREPR_0864	ENOG4108UK5	Transposase
TREPR_0887	ENOG4105Z8H	single-stranded DNA-binding protein
TREPR_0898	ENOG410826E	Dna repair protein radc
TREPR_0900	ENOG4108JJB	ABC transporter
TREPR_0901	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TREPR_0904	ENOG4105C0B	DNA polymerase III (alpha subunit)
TREPR_0912	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
TREPR_0913	ENOG4105C2U	cobyrinic Acid a,c-diamide synthase
TREPR_0917	ENOG4105BZU	Histidine kinase
TREPR_0921	ENOG41084ED	50S ribosomal protein L33
TREPR_0925	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TREPR_0926	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TREPR_0927	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TREPR_0928	ENOG4108VZM	50s ribosomal protein L10
TREPR_0929	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TREPR_0930	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TREPR_0931	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TREPR_0932	ENOG4108JQ7	(ABC) transporter
TREPR_0933	ENOG4105C3U	ABC transporter
TREPR_0934	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TREPR_0935	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_0936	ENOG4105DEF	Extracellular solute-binding protein, family 5
TREPR_0937	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
TREPR_0938	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
TREPR_0939	ENOG4105DC7	peptidase M24
TREPR_0953	ENOG4105CDA	abc transporter atp-binding protein
TREPR_0954	ENOG4105E5Q	amino acid AbC transporter
TREPR_0955	ENOG4106TNF	Periplasmic binding protein
TREPR_0957	ENOG4107QY8	reductase
TREPR_0959	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
TREPR_0962	ENOG4105CDA	abc transporter atp-binding protein
TREPR_0963	ENOG4107RP9	extracellular solute-binding protein, family 3
TREPR_0964	ENOG4105EAD	ABC transporter
TREPR_0965	ENOG4105DRP	amino acid AbC transporter
TREPR_0966	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TREPR_0969	ENOG4105BZU	Histidine kinase
TREPR_0970	ENOG4105D22	carbon starvation protein
TREPR_0971	ENOG41085BT	Protein of unknown function (DUF1312)
TREPR_0974	ENOG4105CJ2	(LipO)protein
TREPR_0976	ENOG4105C7K	acetolactate synthase
TREPR_0977	ENOG4105C01	Dihydroxy-acid dehydratase
TREPR_0979	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TREPR_0980	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TREPR_0981	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TREPR_0982	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TREPR_0986	ENOG410620I	Diguanylate cyclase
TREPR_0988	ENOG4108FRU	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
TREPR_0989	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
TREPR_0998	ENOG41084YP	30S ribosomal protein S21
TREPR_1001	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TREPR_1005	ENOG4107YHD	transcriptional regulator
TREPR_1015	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TREPR_1016	ENOG4107QYI	peptidase
TREPR_1019	ENOG4105C0D	helicase
TREPR_1021	ENOG4105UQX	Mate efflux family protein
TREPR_1023	ENOG4108VJ1	Transcriptional regulator (CarD family
TREPR_1025	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TREPR_1026	ENOG4105CSM	endonuclease III
TREPR_1030	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TREPR_1033	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TREPR_1046	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
TREPR_1047	ENOG41064MX	Tetr family transcriptional regulator
TREPR_1050	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
TREPR_1052	ENOG4105D4B	ABC, transporter
TREPR_1054	ENOG4105BZU	Histidine kinase
TREPR_1058	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TREPR_1061	ENOG4106HK8	GPR1 FUN34 yaaH family protein
TREPR_1062	ENOG4105C0P	Mg chelatase subunit ChlI
TREPR_1063	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TREPR_1066	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TREPR_1067	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
TREPR_1069	ENOG4105C3G	gtp-binding protein
TREPR_1070	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TREPR_1075	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TREPR_1076	ENOG4107YU2	histidine triad (hIT) protein
TREPR_1078	ENOG4105WMR	Protein CrcB homolog
TREPR_1079	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TREPR_1080	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TREPR_1081	ENOG410841Q	phosphoesterase PA-phosphatase related protein
TREPR_1085	ENOG4105D2N	Aldolase
TREPR_1101	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TREPR_1104	ENOG4108HU6	Metal dependent phosphohydrolase
TREPR_1105	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TREPR_1107	ENOG4105DC7	peptidase M24
TREPR_1116	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TREPR_1117	ENOG4105W06	Cupin 2, conserved barrel domain protein
TREPR_1118	ENOG4105D64	Mechanosensitive ion channel
TREPR_1123	ENOG4105C32	Amino acid ABC transporter (Permease)
TREPR_1124	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TREPR_1125	ENOG4105C0Z	ABC transporter
TREPR_1126	ENOG4108IV0	ABC, transporter
TREPR_1127	ENOG4105W87	Cbs domain
TREPR_1128	ENOG4105E0A	ABC, transporter
TREPR_1129	ENOG4105EHG	Permease protein
TREPR_1133	ENOG4107ENK	receptor
TREPR_1140	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
TREPR_1141	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TREPR_1143	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
TREPR_1145	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
TREPR_1148	ENOG4107WUB	V-type ATPase 116 kDa subunit
TREPR_1152	ENOG4107RVI	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TREPR_1153	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TREPR_1166	ENOG4108UQV	Membrane
TREPR_1169	ENOG4108YBP	pseudouridine synthase
TREPR_1170	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
TREPR_1172	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TREPR_1173	ENOG4108IQE	Amp-dependent synthetase and ligase
TREPR_1175	ENOG4105MYT	Heat shock protein
TREPR_1176	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
TREPR_1177	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
TREPR_1179	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TREPR_1180	ENOG4108120	Pasta domain protein
TREPR_1182	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TREPR_1185	ENOG4107QSS	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity)
TREPR_1193	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TREPR_1202	ENOG4107THF	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TREPR_1205	ENOG4107Y80	Major Facilitator superfamily
TREPR_1206	ENOG4107TVT	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TREPR_1209	ENOG4107SJN	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TREPR_1211	ENOG4105GRF	N-glycosylase DNA lyase
TREPR_1214	ENOG4107AYK	membrAne
TREPR_1215	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TREPR_1218	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TREPR_1219	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
TREPR_1220	ENOG4105C0H	protease
TREPR_1224	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TREPR_1226	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
TREPR_1228	ENOG4105C28	cystathionine
TREPR_1231	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
TREPR_1232	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
TREPR_1233	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
TREPR_1234	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
TREPR_1235	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
TREPR_1236	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
TREPR_1237	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TREPR_1249	ENOG4105BZU	Histidine kinase
TREPR_1250	ENOG4105BZU	Histidine kinase
TREPR_1251	ENOG4105BZU	Histidine kinase
TREPR_1254	ENOG4105BZU	Histidine kinase
TREPR_1255	ENOG4105BZU	Histidine kinase
TREPR_1256	ENOG4105BZU	Histidine kinase
TREPR_1257	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_1258	ENOG4105BZU	Histidine kinase
TREPR_1260	ENOG4105BZU	Histidine kinase
TREPR_1261	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_1265	ENOG4105BZJ	Electron transfer flavoprotein
TREPR_1266	ENOG4105C10	Electron transfer flavoprotein
TREPR_1268	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
TREPR_1269	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
TREPR_1270	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TREPR_1276	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TREPR_1277	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TREPR_1278	ENOG4105CHR	reductase
TREPR_1279	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TREPR_1280	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TREPR_1284	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
TREPR_1286	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
TREPR_1287	ENOG4105CI0	Citrate lyase
TREPR_1288	ENOG4105CHY	citrate lyase, alpha
TREPR_1289	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
TREPR_1299	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
TREPR_1301	ENOG4107YT1	Glutamate mutase subunit sigma
TREPR_1306	ENOG4106DSS	Tartrate dehydratase subunit alpha
TREPR_1309	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
TREPR_1311	ENOG4108HHA	Transketolase
TREPR_1313	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TREPR_1315	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
TREPR_1316	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
TREPR_1317	ENOG4105JXH	GntR family transcriptional regulator
TREPR_1321	ENOG4108JNI	Alpha beta hydrolase
TREPR_1323	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
TREPR_1324	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
TREPR_1328	ENOG4105F2F	Xylan 1,4-beta-xylosidase (EC 3.2.1.37)
TREPR_1332	ENOG4105DEF	Extracellular solute-binding protein, family 5
TREPR_1337	ENOG4105EBR	Carboxylesterase
TREPR_1338	ENOG4105EBR	Carboxylesterase
TREPR_1340	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
TREPR_1345	ENOG4105C4K	Nad synthetase
TREPR_1353	ENOG4105CDA	abc transporter atp-binding protein
TREPR_1355	ENOG4105EAB	amino acid AbC transporter
TREPR_1357	ENOG4105CGH	5'-nucleotidase
TREPR_1358	ENOG4105DFD	Na H antiporter
TREPR_1360	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
TREPR_1361	ENOG4105KIJ	D-ornithine aminomutase S component
TREPR_1362	ENOG4107RH1	pyridoxal-5'-phosphate-dependent protein beta subunit
TREPR_1363	ENOG4105Z5Q	
TREPR_1364	ENOG4108KR4	dihydrodipicolinate reductase
TREPR_1365	ENOG4106M28	alanine racemase domain protein
TREPR_1366	ENOG4105DBV	ornithine carbamoyltransferase
TREPR_1368	ENOG4105C34	Pseudouridine synthase
TREPR_1369	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TREPR_1372	ENOG4105DTQ	mandelate racemase muconate lactonizing
TREPR_1373	ENOG4108JQ7	(ABC) transporter
TREPR_1375	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_1377	ENOG4105DEF	Extracellular solute-binding protein, family 5
TREPR_1379	ENOG4105BZ1	(ABC) transporter
TREPR_1380	ENOG4108IG5	Transcriptional regulator
TREPR_1383	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
TREPR_1394	ENOG4108VAU	general secretion pathway protein G
TREPR_1396	ENOG4107QHF	type ii secretion system protein e
TREPR_1397	ENOG4105E4G	Type IV pilus
TREPR_1401	ENOG410667J	hydrolase
TREPR_1406	ENOG41082AG	Plasmid maintenance system antidote protein
TREPR_1420	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TREPR_1439	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
TREPR_1449	ENOG4107SJW	iron permease, FTR1
TREPR_1450	ENOG4108SDV	Periplasmic Protein
TREPR_1453	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TREPR_1454	ENOG4105C19	ABC transporter
TREPR_1457	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TREPR_1459	ENOG4105DPN	Oligoendopeptidase f
TREPR_1465	ENOG4107RUE	extracellular solute-binding protein family 1
TREPR_1466	ENOG4105D38	putrescine abc transporter
TREPR_1467	ENOG4105F38	ABC transporter, permease
TREPR_1468	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_1471	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TREPR_1472	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TREPR_1475	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TREPR_1476	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TREPR_1477	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TREPR_1478	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TREPR_1479	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TREPR_1480	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TREPR_1481	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TREPR_1482	ENOG41082G4	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TREPR_1483	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TREPR_1484	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TREPR_1485	ENOG41086S0	50s ribosomal protein l29
TREPR_1486	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TREPR_1487	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TREPR_1488	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TREPR_1490	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
TREPR_1491	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TREPR_1492	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TREPR_1493	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TREPR_1494	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TREPR_1495	ENOG4105VPB	50S ribosomal protein L30
TREPR_1496	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TREPR_1497	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TREPR_1498	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TREPR_1499	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TREPR_1500	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TREPR_1501	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TREPR_1502	ENOG4108ZT0	50S ribosomal protein l17
TREPR_1503	ENOG4106DC9	
TREPR_1504	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TREPR_1505	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TREPR_1506	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TREPR_1509	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_1510	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
TREPR_1511	ENOG4105C4Y	ABC transporter
TREPR_1512	ENOG4105F8D	glycoside hydrolase family 4
TREPR_1513	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_1519	ENOG4105C2J	ABC transporter
TREPR_1520	ENOG4105CNN	ABC, transporter
TREPR_1521	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
TREPR_1523	ENOG4105C5H	ABC transporter
TREPR_1527	ENOG4105D38	putrescine abc transporter
TREPR_1529	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TREPR_1530	ENOG4108JQ7	(ABC) transporter
TREPR_1542	ENOG4108RAC	Rubrerythrin
TREPR_1545	ENOG4105VIE	preprotein translocase, subunit YajC
TREPR_1546	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TREPR_1547	ENOG4107XHD	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TREPR_1548	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TREPR_1549	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
TREPR_1555	ENOG4108Q52	Methyltransferase cognate corrinoid protein
TREPR_1559	ENOG4107RCC	Major Facilitator Superfamily
TREPR_1561	ENOG4105DUM	transcriptional regulator, lysR family
TREPR_1569	ENOG4105C3S	Mate efflux family protein
TREPR_1570	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TREPR_1573	ENOG4105D8G	Major Facilitator superfamily
TREPR_1575	ENOG4108WS4	fmn reductase
TREPR_1579	ENOG4105E4C	Lytic transglycosylase catalytic
TREPR_1582	ENOG4108UZX	fmn reductase
TREPR_1584	ENOG4105FA0	parb-like partition protein
TREPR_1587	ENOG4105EBR	Carboxylesterase
TREPR_1588	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TREPR_1589	ENOG4108NVR	Methyl-accepting chemotaxis
TREPR_1605	ENOG4105CS2	ec 3.2.1.21
TREPR_1606	ENOG4105C01	Dihydroxy-acid dehydratase
TREPR_1607	ENOG4107QM2	Aldo Keto reductase
TREPR_1611	ENOG4105CS2	ec 3.2.1.21
TREPR_1612	ENOG4105CKB	glycosidase
TREPR_1614	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
TREPR_1619	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TREPR_1620	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TREPR_1621	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
TREPR_1622	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TREPR_1623	ENOG4108KS2	transglutaminase domain protein
TREPR_1626	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_1627	ENOG4105C8N	cysteinyl-tRNA synthetase
TREPR_1628	ENOG4105C3Q	Glycosyl transferase, family 2
TREPR_1633	ENOG4105BZU	Histidine kinase
TREPR_1635	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TREPR_1637	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TREPR_1642	ENOG4105KCK	Peptidoglycan-associated lipoprotein
TREPR_1645	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TREPR_1646	ENOG41084MZ	50S ribosomal protein L35
TREPR_1647	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TREPR_1648	ENOG4106BH8	
TREPR_1649	ENOG4106BMT	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
TREPR_1650	ENOG4105EIP	mannose-6-phosphate isomerase
TREPR_1651	ENOG41082MQ	UPF0178 protein
TREPR_1652	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_1653	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
TREPR_1654	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_1655	ENOG4105CBS	Chea signal transduction histidine kinase
TREPR_1656	ENOG4107SDU	Methyl-accepting chemotaxis
TREPR_1657	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_1658	ENOG4105BZU	Histidine kinase
TREPR_1659	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
TREPR_1664	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_1666	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TREPR_1670	ENOG4105E0A	ABC, transporter
TREPR_1671	ENOG4105EHG	Permease protein
TREPR_1675	ENOG4105D9Q	decarboxylase (Beta subunit)
TREPR_1676	ENOG4107QSA	Oxaloacetate decarboxylase
TREPR_1682	ENOG41081IW	Inherit from COG: Membrane
TREPR_1684	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TREPR_1685	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
TREPR_1686	ENOG4105C9A	Phoh family
TREPR_1687	ENOG4105CTJ	Metal Dependent Phosphohydrolase
TREPR_1688	ENOG41082QW	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
TREPR_1689	ENOG4105C37	(CBS) domain
TREPR_1695	ENOG4105C7J	ABC transporter, permease
TREPR_1696	ENOG4105D7T	ABC transporter
TREPR_1700	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
TREPR_1701	ENOG4105D5B	Sulfite reductase, subunit A
TREPR_1702	ENOG4107SHJ	sulfite reductase subunit b
TREPR_1703	ENOG410810Y	Sulfite reductase
TREPR_1704	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_1705	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_1708	ENOG4107FKK	extracellular solute-binding protein family 1
TREPR_1710	ENOG4105BZU	Histidine kinase
TREPR_1715	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TREPR_1719	ENOG4105DJV	ribulose-phosphate 3-epimerase
TREPR_1722	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TREPR_1723	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TREPR_1726	ENOG4105ZFX	
TREPR_1727	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
TREPR_1730	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TREPR_1735	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TREPR_1737	ENOG4105DJ0	Poly(A) Polymerase
TREPR_1742	ENOG4105CGH	5'-nucleotidase
TREPR_1743	ENOG4105C34	Pseudouridine synthase
TREPR_1747	ENOG4105D6A	Electron transport complex
TREPR_1750	ENOG4105DGN	Electron transport complex
TREPR_1751	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
TREPR_1755	ENOG4105CHV	Transcription elongation factor NusA
TREPR_1756	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TREPR_1757	ENOG41080JB	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
TREPR_1758	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TREPR_1760	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TREPR_1761	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TREPR_1762	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
TREPR_1766	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
TREPR_1768	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TREPR_1770	ENOG4105D60	lipoprotein releasing system transmembrane protein
TREPR_1771	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TREPR_1773	ENOG4107QM5	aconitate hydratase
TREPR_1775	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TREPR_1779	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
TREPR_1782	ENOG4105CD3	dihydroorotase
TREPR_1783	ENOG4105DC7	peptidase M24
TREPR_1784	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_1786	ENOG4108JQ7	(ABC) transporter
TREPR_1794	ENOG4105E4P	ATPase (AAA
TREPR_1795	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TREPR_1798	ENOG4105E2X	shikimate dehydrogenase
TREPR_1800	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TREPR_1802	ENOG4105KG3	cytidine deaminase
TREPR_1805	ENOG4105D1Z	hydroxypyruvate reductase
TREPR_1808	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TREPR_1809	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TREPR_1827	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_1829	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TREPR_1832	ENOG4108I5C	dEAD DEAH box helicase
TREPR_1833	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TREPR_1836	ENOG4105SFS	phosphoesterase RecJ domain protein
TREPR_1838	ENOG4108SXE	
TREPR_1839	ENOG4107QJD	pyruvate phosphate dikinase
TREPR_1841	ENOG4108IJ2	phosphate acetyltransferase
TREPR_1844	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TREPR_1846	ENOG4105TMB	Formate nitrite transporter
TREPR_1860	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_1879	ENOG4105BZU	Histidine kinase
TREPR_1895	ENOG4107R0U	MotA TolQ exbB proton channel
TREPR_1903	ENOG4108J1Q	
TREPR_1911	ENOG4108JA2	transcriptioN-repair coupling factor
TREPR_1913	ENOG4105E9Q	Acyl-transferase
TREPR_1920	ENOG4105I03	Flagellin
TREPR_1921	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
TREPR_1922	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
TREPR_1923	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_1924	ENOG41072GX	Peptidase M22 Glycoprotease
TREPR_1925	ENOG4105K8N	protein family UPF0079, ATPase
TREPR_1932	ENOG4105I03	Flagellin
TREPR_1935	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TREPR_1936	ENOG4105C8B	TIGR00159 family
TREPR_1937	ENOG4105TKT	ybbr family
TREPR_1938	ENOG41083V3	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
TREPR_1940	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TREPR_1941	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TREPR_1942	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
TREPR_1943	ENOG4108YZG	isomerase
TREPR_1945	ENOG41086BH	Binds directly to 16S ribosomal RNA (By similarity)
TREPR_1946	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
TREPR_1947	ENOG4107RI4	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
TREPR_1950	ENOG4105CEV	competence damage-inducible protein
TREPR_1951	ENOG4108S10	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TREPR_1957	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_1959	ENOG4108JQ7	(ABC) transporter
TREPR_1963	ENOG4108J1Q	
TREPR_1965	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
TREPR_1966	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
TREPR_1967	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TREPR_1968	ENOG4108JQ1	Dehydrogenase
TREPR_1969	ENOG4105DXN	mazG family
TREPR_1970	ENOG4105KT7	mgtC SapB transporter
TREPR_1972	ENOG4105ETE	Transcriptional regulator (LacI family
TREPR_1974	ENOG4107RUE	extracellular solute-binding protein family 1
TREPR_1975	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_1981	ENOG4107RCV	ABC transporter, permease
TREPR_1982	ENOG4105C4Y	ABC transporter
TREPR_1985	ENOG4105BZU	Histidine kinase
TREPR_1986	ENOG4105BZU	Histidine kinase
TREPR_1988	ENOG4105IRK	Glycosyl transferase (Group 1
TREPR_1990	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TREPR_1995	ENOG4107QWW	Cell wall formation (By similarity)
TREPR_1997	ENOG4105IJJ	transcriptional regulator, crp fnr family
TREPR_2004	ENOG41073RW	Cytoplasmic filament protein A
TREPR_2015	ENOG4107WYG	Transcriptional regulator, luxr family
TREPR_2024	ENOG4108F3G	Type I restriction-modification system, R subunit
TREPR_2026	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TREPR_2029	ENOG4105C0B	DNA polymerase III (alpha subunit)
TREPR_2065	ENOG4105M6F	mutator MutT protein
TREPR_2067	ENOG4108T5G	Adenylate
TREPR_2068	ENOG4105BZU	Histidine kinase
TREPR_2069	ENOG4105BZU	Histidine kinase
TREPR_2072	ENOG4105M6F	mutator MutT protein
TREPR_2073	ENOG4108JU6	CBS domain protein
TREPR_2122	ENOG41060A7	DNA polymerase beta domain protein region
TREPR_2124	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TREPR_2126	ENOG4105DZS	Phenylacetate-CoA ligase
TREPR_2127	ENOG4108JQ7	(ABC) transporter
TREPR_2128	ENOG4105C3U	ABC transporter
TREPR_2129	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_2131	ENOG4108J59	Extracellular solute-binding protein, family 5
TREPR_2137	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
TREPR_2145	ENOG4105DZS	Phenylacetate-CoA ligase
TREPR_2164	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
TREPR_2177	ENOG4105EMU	Dehydrogenase
TREPR_2209	ENOG4105CJN	penicillin-binding protein
TREPR_2211	ENOG4105DR5	peptidase
TREPR_2214	ENOG4105DZ1	carboxypeptidase
TREPR_2215	ENOG4105C5S	asparaginyl-tRNA synthetase
TREPR_2218	ENOG4106UUF	
TREPR_2220	ENOG4108YYH	Nadph-dependent fmn reductase
TREPR_2221	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TREPR_2222	ENOG4107JR8	Colicin v production protein
TREPR_2223	ENOG4107QRG	dna polymerase iii
TREPR_2224	ENOG4107SGM	protein serine threonine phosphatase
TREPR_2225	ENOG41083UI	stage II sporulation protein
TREPR_2227	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TREPR_2228	ENOG4105BZU	Histidine kinase
TREPR_2229	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
TREPR_2235	ENOG4105VZ9	UPF0235 protein
TREPR_2238	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TREPR_2242	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TREPR_2243	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
TREPR_2244	ENOG4105C98	muts2 protein
TREPR_2248	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
TREPR_2249	ENOG4107QP8	phosphohexose isomerase
TREPR_2253	ENOG4105CQ7	ATP-dependent helicase
TREPR_2255	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TREPR_2271	ENOG4105E4P	ATPase (AAA
TREPR_2279	ENOG4105ESI	atpase involved in dna repair
TREPR_2280	ENOG4105DZR	Type I site-specific deoxyribonuclease
TREPR_2283	ENOG4105CVR	type I restriction-modification system
TREPR_2300	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_2301	ENOG4105BZU	Histidine kinase
TREPR_2308	ENOG410904A	RNA polymerase
TREPR_2311	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
TREPR_2318	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TREPR_2320	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TREPR_2321	ENOG4107QVY	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_2325	ENOG4105DFF	Rod shape-determining protein mreb
TREPR_2326	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
TREPR_2328	ENOG4105CJN	penicillin-binding protein
TREPR_2329	ENOG4105CNI	cell division protein FtsW
TREPR_2331	ENOG4105CH2	amidohydrolase
TREPR_2332	ENOG4105D01	(LipO)protein
TREPR_2333	ENOG4108UMI	ABC transporter, permease
TREPR_2334	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_2338	ENOG4108JUA	Transcriptional regulator
TREPR_2339	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TREPR_2340	ENOG4105FE9	pseudouridine synthase
TREPR_2341	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
TREPR_2342	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
TREPR_2344	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TREPR_2347	ENOG4105M6F	mutator MutT protein
TREPR_2352	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TREPR_2357	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
TREPR_2362	ENOG4105D49	3-dehydroquinate synthase
TREPR_2365	ENOG4105DTI	Phosphonopyruvate decarboxylase
TREPR_2366	ENOG4107STF	Involved in phosphonate degradation (By similarity)
TREPR_2367	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TREPR_2369	ENOG4105MFV	ABC-2 type transporter
TREPR_2371	ENOG4105EY8	ABC transporter
TREPR_2373	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
TREPR_2374	ENOG4105FAW	cDP-glucose 4,6-dehydratase
TREPR_2375	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
TREPR_2378	ENOG4105EQK	-acetyltransferase
TREPR_2380	ENOG4105H63	Glycosyl transferase, family 2
TREPR_2382	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
TREPR_2383	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
TREPR_2385	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
TREPR_2386	ENOG4108IAJ	Nad-dependent epimerase dehydratase
TREPR_2387	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
TREPR_2388	ENOG4105C30	Nad-dependent epimerase dehydratase
TREPR_2389	ENOG4105ECJ	Glycosyl Transferase
TREPR_2391	ENOG4105K64	Glycosyl transferase, family 2
TREPR_2393	ENOG4108TJN	glycosyl transferase group 1
TREPR_2397	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
TREPR_2398	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
TREPR_2399	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TREPR_2401	ENOG4108TJN	glycosyl transferase group 1
TREPR_2402	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TREPR_2403	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TREPR_2404	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TREPR_2405	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TREPR_2408	ENOG4105D3Q	Sugar transferase
TREPR_2412	ENOG4108Z4J	Cytidine monophosphate kinase
TREPR_2413	ENOG4105DSJ	YicC domain protein
TREPR_2414	ENOG4105DFU	Cell wall formation (By similarity)
TREPR_2415	ENOG4105C34	Pseudouridine synthase
TREPR_2423	ENOG4105D1H	recombination factor protein RarA
TREPR_2426	ENOG4105CN9	Peptidase m42 family protein
TREPR_2427	ENOG4105CN9	Peptidase m42 family protein
TREPR_2428	ENOG4108JQ7	(ABC) transporter
TREPR_2429	ENOG4105C3U	ABC transporter
TREPR_2430	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_2431	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TREPR_2434	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TREPR_2435	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_2441	ENOG4105DXX	methyltransferase
TREPR_2442	ENOG4105DF5	DNA topoisomerase IV, subunit A
TREPR_2443	ENOG4105C6Z	Gluconate
TREPR_2444	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TREPR_2445	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
TREPR_2447	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TREPR_2451	ENOG4105BZU	Histidine kinase
TREPR_2452	ENOG4105CP7	Triose-phosphate isomerase
TREPR_2453	ENOG4105BZA	Phosphoglycerate kinase
TREPR_2454	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TREPR_2456	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_2458	ENOG4107NGC	Flagellar filament outer layer protein
TREPR_2460	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TREPR_2461	ENOG4105CPF	Cell wall formation (By similarity)
TREPR_2465	ENOG4108ZVA	radical SAM domain protein
TREPR_2466	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
TREPR_2467	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
TREPR_2468	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TREPR_2469	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_2470	ENOG4107X35	defense response to bacterium
TREPR_2476	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TREPR_2478	ENOG41090QR	
TREPR_2483	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_2485	ENOG4105CSA	Coproporphyrinogen iii oxidase
TREPR_2488	ENOG4105C3F	Signal peptidase i
TREPR_2489	ENOG4105E6M	Sulphatase-modifying factor protein
TREPR_2490	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TREPR_2493	ENOG410698I	
TREPR_2493	ENOG410698I	
TREPR_2495	ENOG4105X4X	Protein of unknown function DUF115
TREPR_2497	ENOG4105C93	Xylose Isomerase
TREPR_2498	ENOG4105CMG	Carbohydrate kinase
TREPR_2504	ENOG4105DA5	(ABC) transporter
TREPR_2505	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TREPR_2508	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
TREPR_2509	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
TREPR_2515	ENOG4107RIZ	hflk protein
TREPR_2516	ENOG4105EPW	hflc protein
TREPR_2523	ENOG4108JQB	penicillin-binding protein 1C
TREPR_2528	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TREPR_2531	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TREPR_2532	ENOG41068UM	RNA Polymerase
TREPR_2533	ENOG4105D5D	udp-galactopyranose mutase
TREPR_2537	ENOG4105MFV	ABC-2 type transporter
TREPR_2538	ENOG4105EY8	ABC transporter
TREPR_2540	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
TREPR_2541	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
TREPR_2542	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
TREPR_2543	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
TREPR_2544	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
TREPR_2546	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TREPR_2551	ENOG4108NFJ	ABC transporter
TREPR_2555	ENOG4108JIR	Flagellum-specific ATP synthase
TREPR_2556	ENOG4105W2B	Flagellar assembly protein
TREPR_2557	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TREPR_2558	ENOG4107U2N	Flagellar M-ring protein
TREPR_2559	ENOG41069WH	flagellar hook-basal body complex
TREPR_2560	ENOG4108ZC9	flagellar basal-body rod protein flgc
TREPR_2561	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
TREPR_2562	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
TREPR_2563	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
TREPR_2564	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TREPR_2565	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TREPR_2566	ENOG4105C79	DNA protecting protein DprA
TREPR_2568	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TREPR_2569	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
TREPR_2570	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TREPR_2572	ENOG4105CNI	cell division protein FtsW
TREPR_2573	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TREPR_2575	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TREPR_2576	ENOG4107YM1	mraZ protein
TREPR_2579	ENOG41082DI	50s ribosomal protein l31
TREPR_2580	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TREPR_2582	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TREPR_2598	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
TREPR_2599	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TREPR_2600	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TREPR_2602	ENOG4108KMV	Glycosyl transferase (Group 1
TREPR_2603	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
TREPR_2604	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TREPR_2605	ENOG4105C25	Primosomal protein n'
TREPR_2606	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
TREPR_2608	ENOG4105DVT	helicase
TREPR_2619	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
TREPR_2621	ENOG4105CAG	UPF0210 protein
TREPR_2622	ENOG4105VUC	UPF0237 protein
TREPR_2627	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
TREPR_2630	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TREPR_2632	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TREPR_2634	ENOG410805Y	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TREPR_2639	ENOG4105CQ7	ATP-dependent helicase
TREPR_2640	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
TREPR_2641	ENOG4107W7Y	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
TREPR_2647	ENOG4107V28	uracil phosphoribosyltransferase
TREPR_2651	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TREPR_2653	ENOG4107U1W	v-type ATP synthase subunit I
TREPR_2654	ENOG4108WBK	V-type ATP synthase subunit D
TREPR_2655	ENOG4107RQX	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TREPR_2656	ENOG4107RVI	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TREPR_2658	ENOG4108RY1	ATP synthase, subunit E
TREPR_2660	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
TREPR_2666	ENOG4105BZ1	(ABC) transporter
TREPR_2667	ENOG4105BZ1	(ABC) transporter
TREPR_2669	ENOG4108Z03	MAF-like protein
TREPR_2670	ENOG4105CE9	30S ribosomal protein S2
TREPR_2671	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TREPR_2672	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TREPR_2673	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TREPR_2674	ENOG4105KNE	Phosphatidate cytidylyltransferase
TREPR_2675	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TREPR_2677	ENOG4105DZP	Membrane-associated zinc metalloprotease
TREPR_2680	ENOG4105CDU	Replicative dna helicase
TREPR_2681	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TREPR_2683	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TREPR_2684	ENOG4105Z8H	single-stranded DNA-binding protein
TREPR_2685	ENOG41084AY	Binds together with S18 to 16S ribosomal RNA (By similarity)
TREPR_2687	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TREPR_2689	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
TREPR_2690	ENOG41084E5	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TREPR_2691	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TREPR_2693	ENOG4105SXG	
TREPR_2696	ENOG4105CUT	histidyl-tRNA synthetase
TREPR_2697	ENOG4105CHM	Aminotransferase
TREPR_2704	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TREPR_2705	ENOG4105BZU	Histidine kinase
TREPR_2707	ENOG4105RV9	Transcriptional regulator
TREPR_2708	ENOG41062ES	Transcriptional regulator
TREPR_2710	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
TREPR_2723	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
TREPR_2724	ENOG4107QI6	Cysteine desulfurase
TREPR_2727	ENOG4105D01	(LipO)protein
TREPR_2728	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
TREPR_2730	ENOG4105DR4	Methyltransferase
TREPR_2731	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_2733	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
TREPR_2734	ENOG4105CVR	type I restriction-modification system
TREPR_2739	ENOG4105DZR	Type I site-specific deoxyribonuclease
TREPR_2740	ENOG4105E4P	ATPase (AAA
TREPR_2749	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TREPR_2750	ENOG4105DK7	lysyl-tRNA synthetase
TREPR_2751	ENOG4105CY0	Metallo-Beta-Lactamase
TREPR_2754	ENOG4105FA0	parb-like partition protein
TREPR_2755	ENOG4107QJE	Chromosome Partitioning Protein
TREPR_2756	ENOG410667J	hydrolase
TREPR_2757	ENOG4105K6T	rare lipoprotein A
TREPR_2759	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TREPR_2763	ENOG4105D48	metallophosphoesterase
TREPR_2765	ENOG4107S0N	DJ-1 family
TREPR_2769	ENOG4108V1T	peptidylprolyl cis-trans isomerase
TREPR_2770	ENOG4105CT4	transporter
TREPR_2792	ENOG4105ESV	Glycosyl transferase, family 4
TREPR_2794	ENOG4105C3J	Cysteine desulfurase
TREPR_2795	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TREPR_2800	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TREPR_2801	ENOG41080VC	Galactokinase (EC 2.7.1.6)
TREPR_2806	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TREPR_2807	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
TREPR_2811	ENOG4105CGK	Exodeoxyribonuclease III
TREPR_2812	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
TREPR_2813	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TREPR_2814	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
TREPR_2816	ENOG4105DFM	M18 family aminopeptidase
TREPR_2817	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TREPR_2819	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TREPR_2823	ENOG4105C3S	Mate efflux family protein
TREPR_2827	ENOG4108M1M	outer membrane lipoprotein-sorting protein
TREPR_2838	ENOG4105M6F	mutator MutT protein
TREPR_2839	ENOG4105CGH	5'-nucleotidase
TREPR_2845	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_2848	ENOG4105FZW	flagellar biosynthesis regulator FlhF
TREPR_2849	ENOG4105D7B	Flagellar biosynthesis protein flha
TREPR_2850	ENOG4105D00	flagellar biosynthetic protein flhB
TREPR_2851	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
TREPR_2852	ENOG4105VS8	Flagellar biosynthetic protein fliq
TREPR_2853	ENOG4105CN7	Flagellar biosynthetic protein FliP
TREPR_2855	ENOG4105DD5	Flagellar motor switch protein
TREPR_2856	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TREPR_2858	ENOG41064SM	flagellar basal body-associated protein flil
TREPR_2860	ENOG4107XSU	flagellar motor protein motb
TREPR_2861	ENOG4107R0U	MotA TolQ exbB proton channel
TREPR_2863	ENOG4105BZE	flagellar hook protein, FlgE
TREPR_2864	ENOG410822I	Flagellar hook capping protein
TREPR_2872	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
TREPR_2876	ENOG4105C4X	radical SAM domain protein
TREPR_2878	ENOG4105CEV	competence damage-inducible protein
TREPR_2880	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TREPR_2881	ENOG41089BK	Glutamine amido-transferase
TREPR_2883	ENOG4105CGC	Nitrogenase cofactor biosynthesis protein NifB
TREPR_2889	ENOG4108YZA	Nitrogen regulatory protein pii
TREPR_2890	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
TREPR_2893	ENOG4108JUA	Transcriptional regulator
TREPR_2900	ENOG4105C3R	Methionine synthase
TREPR_2903	ENOG4105BZU	Histidine kinase
TREPR_2905	ENOG4108Q52	Methyltransferase cognate corrinoid protein
TREPR_2906	ENOG4105X1Q	TOBE domain protein
TREPR_2907	ENOG4105U3E	Transcriptional regulator
TREPR_2910	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
TREPR_2916	ENOG4105BZU	Histidine kinase
TREPR_2919	ENOG4105CNU	cell division protein FtsK
TREPR_2920	ENOG4105E4C	Lytic transglycosylase catalytic
TREPR_2921	ENOG4108WZM	domain protein
TREPR_2928	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_2930	ENOG4105BZ1	(ABC) transporter
TREPR_2931	ENOG4105BZ1	(ABC) transporter
TREPR_2933	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TREPR_2934	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TREPR_2936	ENOG4105YFD	chemotaxis, protein
TREPR_2937	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
TREPR_2938	ENOG4105CDY	transcriptional regulatory protein
TREPR_2941	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_2944	ENOG4105T73	
TREPR_2946	ENOG4105CHH	sulfate transporter
TREPR_2948	ENOG4105C59	p-type ATPase
TREPR_2950	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
TREPR_2952	ENOG4105CS2	ec 3.2.1.21
TREPR_2953	ENOG4105CGH	5'-nucleotidase
TREPR_2954	ENOG4105C5Y	PTS System
TREPR_2956	ENOG4108KP7	hydrolase
TREPR_2957	ENOG4105CID	antiterminator
TREPR_2961	ENOG4105KME	endoribonuclease L-psp
TREPR_2962	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
TREPR_2963	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
TREPR_2964	ENOG4105DE4	1-phosphofructokinase
TREPR_2968	ENOG4105CTS	PTS system mannitol-specific
TREPR_2971	ENOG4105YFD	chemotaxis, protein
TREPR_2972	ENOG4105CBS	Chea signal transduction histidine kinase
TREPR_2974	ENOG4105CFH	Aspartokinase
TREPR_2975	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
TREPR_2976	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TREPR_2977	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
TREPR_2981	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TREPR_2982	ENOG4108UJD	30S ribosomal protein S9
TREPR_2983	ENOG4105Y3E	Modulates RecA activity (By similarity)
TREPR_2984	ENOG4105C1J	atp-dependent rna helicase
TREPR_2985	ENOG4105CXK	mandelate racemase muconate lactonizing
TREPR_2990	ENOG4105J4Q	Transcriptional regulator
TREPR_2991	ENOG4108UHU	Aldolase
TREPR_2997	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TREPR_2999	ENOG4107RNG	ABC transporter
TREPR_3001	ENOG4105DFW	ABC transporter
TREPR_3003	ENOG4105DFW	ABC transporter
TREPR_3005	ENOG4105C2F	Histidine kinase
TREPR_3007	ENOG4105DR5	peptidase
TREPR_3010	ENOG4105MA4	psp1 domain protein
TREPR_3011	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TREPR_3012	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
TREPR_3013	ENOG4105BZU	Histidine kinase
TREPR_3014	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TREPR_3017	ENOG4108IUZ	ABC transporter
TREPR_3018	ENOG4105UQX	Mate efflux family protein
TREPR_3022	ENOG4107QSE	Dipeptidase
TREPR_3023	ENOG4105CPC	Aldo Keto reductase
TREPR_3027	ENOG4105DIB	Oligopeptide-binding protein
TREPR_3031	ENOG4108JQ7	(ABC) transporter
TREPR_3032	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TREPR_3036	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_3037	ENOG4105E0C	molybdate abc transporter
TREPR_3038	ENOG410901P	UPF0249 protein
TREPR_3039	ENOG4105D48	metallophosphoesterase
TREPR_3042	ENOG4105ECA	phosphoserine phosphatase homoserine phosphotransferase bifunctional protein
TREPR_3043	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TREPR_3046	ENOG4105EW4	(LipO)protein
TREPR_3050	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
TREPR_3051	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
TREPR_3053	ENOG4108W8G	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity)
TREPR_3054	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TREPR_3056	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_3057	ENOG4105BZU	Histidine kinase
TREPR_3058	ENOG4105DHT	Metal Dependent Phosphohydrolase
TREPR_3059	ENOG4105C8Q	Methyl-accepting chemotaxis
TREPR_3060	ENOG4105C2M	dna polymerase I
TREPR_3064	ENOG4107VP5	methyltetrahydrofolate corrinoid iron-sulfur protein methyltransferase
TREPR_3065	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
TREPR_3066	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
TREPR_3067	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
TREPR_3068	ENOG41080XS	Cobyrinic acid ac-diamide synthase
TREPR_3069	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
TREPR_3081	ENOG4105VFE	sira family
TREPR_3082	ENOG4105C9B	Cysteine desulfurase
TREPR_3083	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TREPR_3087	ENOG4105E5Q	amino acid AbC transporter
TREPR_3090	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
TREPR_3091	ENOG4105CIZ	coA-substrate-specific enzyme activase
TREPR_3094	ENOG4107QHI	-hydrogenase
TREPR_3095	ENOG4105BZ8	glutamate synthase
TREPR_3097	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
TREPR_3098	ENOG4105BZ8	glutamate synthase
TREPR_3099	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TREPR_3102	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TREPR_3110	ENOG4108UV1	cellular component movement
TREPR_3112	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TREPR_3115	ENOG4108F3G	Type I restriction-modification system, R subunit
TREPR_3118	ENOG4105DFS	Conserved Protein
TREPR_3124	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TREPR_3125	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
TREPR_3126	ENOG4105CKU	formyltetrahydrofolate synthetase
TREPR_3129	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
TREPR_3130	ENOG4108JJB	ABC transporter
TREPR_3131	ENOG4105X71	Membrane
TREPR_3133	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TREPR_3134	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
TREPR_3137	ENOG41083NY	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TREPR_3151	ENOG4105BZU	Histidine kinase
TREPR_3153	ENOG4105K5M	30s ribosomal protein S16
TREPR_3154	ENOG4105VB6	UPF0109 protein
TREPR_3155	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TREPR_3156	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TREPR_3157	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TREPR_3159	ENOG4105VM1	flagellar
TREPR_3160	ENOG4105CPI	Metal Dependent Phosphohydrolase
TREPR_3161	ENOG4105VFF	UPF0102 protein
TREPR_3163	ENOG4105BZU	Histidine kinase
TREPR_3164	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_3165	ENOG4105BZU	Histidine kinase
TREPR_3176	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
TREPR_3178	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TREPR_3184	ENOG4105FDK	ABC transporter
TREPR_3188	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TREPR_3189	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
TREPR_3194	ENOG4105BZU	Histidine kinase
TREPR_3196	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
TREPR_3200	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TREPR_3203	ENOG4108Z66	YbaK ebsC protein
TREPR_3204	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
TREPR_3205	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TREPR_3206	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TREPR_3207	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TREPR_3209	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TREPR_3210	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TREPR_3212	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
TREPR_3216	ENOG4105C8M	UPF0272 protein
TREPR_3217	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
TREPR_3220	ENOG4106SMU	thiamine transporter membrane protein
TREPR_3221	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_3226	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TREPR_3228	ENOG4108ISG	Major Facilitator
TREPR_3229	ENOG4105C8T	Leucyl-tRNA synthetase
TREPR_3233	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
TREPR_3240	ENOG41067MG	lrgb family
TREPR_3241	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TREPR_3242	ENOG4105C1A	potassium transporter peripheral membrane
TREPR_3254	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TREPR_3255	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TREPR_3256	ENOG4105C98	muts2 protein
TREPR_3264	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TREPR_3266	ENOG4105EFJ	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity)
TREPR_3267	ENOG4105C3U	ABC transporter
TREPR_3268	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_3270	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
TREPR_3271	ENOG4105E0A	ABC, transporter
TREPR_3272	ENOG4105EHG	Permease protein
TREPR_3276	ENOG4105EHG	Permease protein
TREPR_3278	ENOG41089UC	methyltransferase, type 11
TREPR_3281	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TREPR_3284	ENOG4105DUM	transcriptional regulator, lysR family
TREPR_3287	ENOG4107QIZ	NADH dehydrogenase
TREPR_3288	ENOG4107QHI	-hydrogenase
TREPR_3289	ENOG4105C0B	DNA polymerase III (alpha subunit)
TREPR_3294	ENOG4108JJB	ABC transporter
TREPR_3297	ENOG4108EKI	Dehydrogenase
TREPR_3300	ENOG4107QHI	-hydrogenase
TREPR_3301	ENOG4107QIZ	NADH dehydrogenase
TREPR_3307	ENOG4105CFG	Acts as a chaperone (By similarity)
TREPR_3308	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TREPR_3314	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
TREPR_3316	ENOG4105CHY	citrate lyase, alpha
TREPR_3317	ENOG4107QM5	aconitate hydratase
TREPR_3321	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
TREPR_3325	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
TREPR_3326	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TREPR_3329	ENOG4105DG4	malate L-lactate dehydrogenase
TREPR_3330	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
TREPR_3333	ENOG4105CAS	nag kinase
TREPR_3334	ENOG4105C8Y	Acetylornithine aminotransferase
TREPR_3335	ENOG4108WS4	fmn reductase
TREPR_3337	ENOG4105CDA	abc transporter atp-binding protein
TREPR_3343	ENOG4105CDA	abc transporter atp-binding protein
TREPR_3344	ENOG4105E5Q	amino acid AbC transporter
TREPR_3347	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_3348	ENOG4105BZU	Histidine kinase
TREPR_3350	ENOG4105CDH	Citrulline--aspartate ligase
TREPR_3357	ENOG4105CH7	arginosuccinase
TREPR_3358	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
TREPR_3359	ENOG4105CE4	GlcNAc 6-P deacetylase
TREPR_3360	ENOG4105CNW	domain protein
TREPR_3361	ENOG4107Z9R	response regulator
TREPR_3362	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TREPR_3365	ENOG4105CPC	Aldo Keto reductase
TREPR_3367	ENOG4105W5Q	DNA repair protein (RadC
TREPR_3374	ENOG4105CIB	oxidoreductase Domain protein
TREPR_3378	ENOG4107QKZ	Ompa motb domain protein
TREPR_3381	ENOG4105C9M	aspartyl-trna synthetase
TREPR_3383	ENOG4105FGV	Chromate
TREPR_3387	ENOG4105CND	Glycosyl transferase, family 2
TREPR_3399	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TREPR_3402	ENOG4107YT1	Glutamate mutase subunit sigma
TREPR_3403	ENOG410874W	AraC family transcriptional regulator
TREPR_3404	ENOG410874W	AraC family transcriptional regulator
TREPR_3405	ENOG4108VB1	regulatoR
TREPR_3406	ENOG4108VB1	regulatoR
TREPR_3411	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_3416	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TREPR_3417	ENOG4105W2W	Cytotoxic translational repressor of toxin-antitoxin stability system
TREPR_3421	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TREPR_3429	ENOG41090KN	UPF0303 protein
TREPR_3430	ENOG4105BZU	Histidine kinase
TREPR_3432	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
TREPR_3433	ENOG4105C2I	pirin domain protein
TREPR_3434	ENOG4108QBX	(LipO)protein
TREPR_3442	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
TREPR_3443	ENOG4105C75	arginyL-tRNA synthetase
TREPR_3444	ENOG4107QI1	Mate efflux family protein
TREPR_3448	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TREPR_3450	ENOG4105K46	50S ribosomal protein l27
TREPR_3451	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TREPR_3452	ENOG4107X4V	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TREPR_3458	ENOG4105CK7	Sodium proline symporter
TREPR_3460	ENOG4107SET	aldo keto reductase
TREPR_3465	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
TREPR_3468	ENOG4105CJR	Integral membrane protein (MviN
TREPR_3469	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TREPR_3479	ENOG4105CGA	flagellar basal-body rod protein FlgG
TREPR_3480	ENOG4105CGA	flagellar basal-body rod protein FlgG
TREPR_3485	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TREPR_3486	ENOG4105DFA	alanine racemase domain protein
TREPR_3490	ENOG4105C22	threonyL-tRNA synthetase
TREPR_3491	ENOG4105DAP	Nicotinate phosphoribosyltransferase
TREPR_3492	ENOG4108RWI	nicotinamidase
TREPR_3498	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
TREPR_3499	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
TREPR_3500	ENOG4105CD3	dihydroorotase
TREPR_3504	ENOG4105BZU	Histidine kinase
TREPR_3505	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TREPR_3506	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
TREPR_3507	ENOG4108UMI	ABC transporter, permease
TREPR_3508	ENOG4105K63	Thioredoxin
TREPR_3511	ENOG4108JUA	Transcriptional regulator
TREPR_3513	ENOG4108YZA	Nitrogen regulatory protein pii
TREPR_3527	ENOG4105F8V	Hydrolase, tatD family
TREPR_3530	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
TREPR_3531	ENOG4107TFB	basic membrane
TREPR_3532	ENOG4108JQ9	ABC transporter
TREPR_3533	ENOG4105UIB	(ABC) transporter
TREPR_3541	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
TREPR_3545	ENOG41080XS	Cobyrinic acid ac-diamide synthase
TREPR_3551	ENOG4105CTQ	phosphohexokinase
TREPR_3554	ENOG41062BZ	domain protein
TREPR_3562	ENOG4105C5X	domain protein
TREPR_3563	ENOG4105EAM	Na Pi-cotransporter
TREPR_3564	ENOG4105BZG	amino acid carrier protein
TREPR_3565	ENOG4105DCF	alanine dehydrogenase
TREPR_3567	ENOG4105DUM	transcriptional regulator, lysR family
TREPR_3572	ENOG4105C3S	Mate efflux family protein
TREPR_3574	ENOG4105E4P	ATPase (AAA
TREPR_3576	ENOG4105C31	Tryptophanyl-tRNA synthetase
TREPR_3577	ENOG4105K95	(LipO)protein
TREPR_3578	ENOG4105K95	(LipO)protein
TREPR_3579	ENOG4105C2J	ABC transporter
TREPR_3589	ENOG4105WH1	Two component transcriptional regulator luxr family
TREPR_3591	ENOG4105F8J	Adenylate Guanylate cyclase
TREPR_3593	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TREPR_3594	ENOG4107QHI	-hydrogenase
TREPR_3595	ENOG4107QIZ	NADH dehydrogenase
TREPR_3596	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
TREPR_3598	ENOG4105VVB	
TREPR_3600	ENOG4105D7W	serine acetyltransferase
TREPR_3601	ENOG4105D78	K07001 NTE family protein
TREPR_3603	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TREPR_3606	ENOG4105KY8	Rubrerythrin
TREPR_3612	ENOG4107QVY	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_3614	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
TREPR_3615	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
TREPR_3616	ENOG4105EHG	Permease protein
TREPR_3617	ENOG4105E0A	ABC, transporter
TREPR_3623	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
TREPR_3629	ENOG4105DZR	Type I site-specific deoxyribonuclease
TREPR_3637	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TREPR_3638	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TREPR_3639	ENOG4105C5S	asparaginyl-tRNA synthetase
TREPR_3640	ENOG4105HKU	nucleoside recognition domain-containing protein
TREPR_3642	ENOG4105HCZ	
TREPR_3654	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TREPR_3661	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TREPR_3662	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TREPR_3663	ENOG4105C3U	ABC transporter
TREPR_3664	ENOG4108JQ7	(ABC) transporter
TREPR_3667	ENOG4107QSI	ABC, transporter
TREPR_3668	ENOG4107QW8	radical SAM domain protein
TREPR_3672	ENOG4105CJW	magnesium transporter
TREPR_3673	ENOG4108IJ0	Aspartate ammonia-lyase
TREPR_3674	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TREPR_3676	ENOG4108W2Y	isochorismatase
TREPR_3691	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TREPR_3700	ENOG4105F8V	Hydrolase, tatD family
TREPR_3706	ENOG4108IG5	Transcriptional regulator
TREPR_3713	ENOG4105C6T	cysteine synthase
TREPR_3717	ENOG4105ESN	nucleotide-binding protein
TREPR_3718	ENOG4105C9B	Cysteine desulfurase
TREPR_3719	ENOG4105D7W	serine acetyltransferase
TREPR_3721	ENOG4105E5Q	amino acid AbC transporter
TREPR_3722	ENOG4105EAB	amino acid AbC transporter
TREPR_3733	ENOG4108UW5	maltose o-acetyltransferase
TREPR_3739	ENOG4108IAJ	Nad-dependent epimerase dehydratase
TREPR_3742	ENOG4105BZ1	(ABC) transporter
TREPR_3747	ENOG4105ECJ	Glycosyl Transferase
TREPR_3756	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
TREPR_3757	ENOG4105DD7	kinase (PfkB family
TREPR_3758	ENOG41076CZ	activating enzyme
TREPR_3759	ENOG4105G0K	glycine radical enzyme YjjI family
TREPR_3760	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
TREPR_3762	ENOG4108V7D	UPF0397 protein
TREPR_3767	ENOG4105G3C	Type iv pilus assembly
TREPR_3770	ENOG4105XMA	
TREPR_3771	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TREPR_3773	ENOG4107R2T	n-acetylglutamate synthase
TREPR_3774	ENOG4105C12	Phosphoribosylglycinamide synthetase
TREPR_3777	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
TREPR_3780	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TREPR_3782	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TREPR_3783	ENOG41061GT	Aldolase
TREPR_3784	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
TREPR_3787	ENOG4105C8V	SAICAR synthetase
TREPR_3788	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TREPR_3789	ENOG4105CJR	Integral membrane protein (MviN
TREPR_3794	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
TREPR_3796	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
TREPR_3797	ENOG4109031	
TREPR_3800	ENOG4108Z29	Flavodoxin
TREPR_3802	ENOG4108JQ1	Dehydrogenase
TREPR_3803	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
TREPR_3805	ENOG4105C5H	ABC transporter
TREPR_3807	ENOG4108UT2	hemolysin iii
TREPR_3809	ENOG4105D6S	protein involved in catabolism of external DNA
TREPR_3811	ENOG4105SFS	phosphoesterase RecJ domain protein
TREPR_3813	ENOG4105DB7	PHP domain protein
TREPR_3815	ENOG4105IJJ	transcriptional regulator, crp fnr family
TREPR_3817	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
TREPR_3818	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TREPR_3819	ENOG4105CB5	ATP-dependent DNA helicase recG
TREPR_3821	ENOG4105C0B	DNA polymerase III (alpha subunit)
TREPR_3832	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
TREPR_3835	ENOG4107QN2	dihydrolipoyl dehydrogenase
TREPR_3836	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
TREPR_3837	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TREPR_3840	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TREPR_3841	ENOG4107WGG	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TREPR_3844	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
TREPR_3849	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TREPR_3858	ENOG4105C3M	thioredoxin reductase
TREPR_3866	ENOG4105D7B	Flagellar biosynthesis protein flha
TREPR_3874	ENOG4105D17	glycoside hydrolase, family 3 domain protein
TREPR_3876	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
TREPR_3877	ENOG4105CQ2	DNA polymerase
TREPR_3878	ENOG4105CMQ	Chloride channel
TREPR_3881	ENOG4105CSA	Coproporphyrinogen iii oxidase
TREPR_3882	ENOG410631K	Membrane