locus-tag	class	description
TREPR_0001	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TREPR_0001	COG2755	lipolytic protein G-D-S-L family
TREPR_0003	COG1696	Membrane protein involved in D-alanine export
TREPR_0007	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TREPR_0008	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_0020	COG1216	Glycosyl transferase, family 2
TREPR_0033	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TREPR_0039	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TREPR_0049	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TREPR_0052	COG0840	transmembrane signaling receptor activity
TREPR_0060	COG0793	Belongs to the peptidase S41A family
TREPR_0066	COG1842	Phage shock protein A
TREPR_0072	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TREPR_0078	COG0784	Response regulator, receiver
TREPR_0078	COG2205	protein histidine kinase activity
TREPR_0085	COG3842	ATPase activity
TREPR_0087	COG1176	ABC-type spermidine putrescine transport system, permease component I
TREPR_0088	COG0584	glycerophosphoryl diester phosphodiesterase
TREPR_0106	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TREPR_0108	COG3842	ATPase activity
TREPR_0109	COG1196	nuclear chromosome segregation
TREPR_0119	COG0534	Mate efflux family protein
TREPR_0120	COG1410	methionine synthase
TREPR_0120	COG0646	methionine synthase
TREPR_0125	COG0629	single-stranded DNA binding
TREPR_0131	COG1349	DNA-binding transcription factor activity
TREPR_0132	COG1349	DNA-binding transcription factor activity
TREPR_0133	COG1028	Short-chain dehydrogenase reductase Sdr
TREPR_0134	COG1063	alcohol dehydrogenase
TREPR_0136	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TREPR_0143	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TREPR_0144	COG3191	aminopeptidase activity
TREPR_0148	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TREPR_0149	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TREPR_0150	COG2900	Belongs to the SlyX family
TREPR_0155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TREPR_0157	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TREPR_0161	COG4191	Histidine kinase
TREPR_0165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TREPR_0170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TREPR_0173	COG2195	Cleaves the N-terminal amino acid of tripeptides
TREPR_0175	COG1022	Amp-dependent synthetase and ligase
TREPR_0176	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TREPR_0178	COG0714	Associated with various cellular activities
TREPR_0183	COG2205	protein histidine kinase activity
TREPR_0183	COG0784	Response regulator, receiver
TREPR_0184	COG2203	Gaf domain
TREPR_0184	COG2199	diguanylate cyclase activity
TREPR_0195	COG0438	transferase activity, transferring glycosyl groups
TREPR_0203	COG1215	transferase activity, transferring glycosyl groups
TREPR_0218	COG0519	Catalyzes the synthesis of GMP from XMP
TREPR_0218	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TREPR_0219	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TREPR_0226	COG0517	IMP dehydrogenase activity
TREPR_0226	COG0516	GMP reductase activity
TREPR_0227	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TREPR_0230	COG0785	Cytochrome C biogenesis protein
TREPR_0233	COG1744	ABC transporter substrate-binding protein PnrA-like
TREPR_0234	COG1129	ABC transporter
TREPR_0240	COG1640	4-alpha-glucanotransferase
TREPR_0245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TREPR_0248	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TREPR_0249	COG2895	sulfate adenylyltransferase (ATP) activity
TREPR_0250	COG0175	sulfate reduction
TREPR_0253	COG4208	sulfate ABC transporter
TREPR_0254	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TREPR_0255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TREPR_0256	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TREPR_0259	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TREPR_0259	COG1648	precorrin-2 dehydrogenase activity
TREPR_0262	COG0113	porphobilinogen synthase activity
TREPR_0264	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TREPR_0266	COG1879	ABC-type sugar transport system periplasmic component
TREPR_0267	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREPR_0268	COG1129	ABC transporter
TREPR_0270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TREPR_0274	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TREPR_0275	COG0592	DNA-directed DNA polymerase activity
TREPR_0277	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TREPR_0279	COG0187	DNA topoisomerase II activity
TREPR_0282	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TREPR_0284	COG3842	ATPase activity
TREPR_0288	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TREPR_0291	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TREPR_0293	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TREPR_0302	COG0667	Aldo Keto reductase
TREPR_0303	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TREPR_0306	COG4657	Part of a membrane complex involved in electron transport
TREPR_0307	COG4660	Part of a membrane complex involved in electron transport
TREPR_0308	COG4659	FMN binding
TREPR_0309	COG4658	electron transport chain
TREPR_0310	COG4656	Part of a membrane complex involved in electron transport
TREPR_0311	COG0484	heat shock protein binding
TREPR_0312	COG0443	Heat shock 70 kDa protein
TREPR_0313	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TREPR_0314	COG1968	undecaprenyl-diphosphatase activity
TREPR_0318	COG1373	ATPase (AAA superfamily
TREPR_0333	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_0334	COG3959	Transketolase, thiamine diphosphate binding domain
TREPR_0336	COG0546	phosphoglycolate phosphatase activity
TREPR_0340	COG0367	asparagine synthase
TREPR_0342	COG0438	transferase activity, transferring glycosyl groups
TREPR_0344	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_0345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TREPR_0348	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TREPR_0353	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TREPR_0367	COG1181	Belongs to the D-alanine--D-alanine ligase family
TREPR_0368	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TREPR_0369	COG2267	carboxylic ester hydrolase activity
TREPR_0370	COG0778	Nitroreductase
TREPR_0371	COG0612	Peptidase, M16
TREPR_0372	COG0519	Catalyzes the synthesis of GMP from XMP
TREPR_0383	COG0512	Glutamine amidotransferase of anthranilate synthase
TREPR_0383	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TREPR_0384	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TREPR_0387	COG0133	tryptophan synthase activity
TREPR_0388	COG0159	tryptophan synthase activity
TREPR_0391	COG3875	lactate racemase activity
TREPR_0393	COG0281	malic enzyme
TREPR_0395	COG0126	phosphoglycerate kinase activity
TREPR_0396	COG1082	Xylose isomerase domain protein TIM barrel
TREPR_0397	COG3962	Belongs to the TPP enzyme family
TREPR_0399	COG0673	inositol 2-dehydrogenase activity
TREPR_0402	COG1129	ABC transporter
TREPR_0403	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREPR_0406	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TREPR_0407	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TREPR_0408	COG0673	inositol 2-dehydrogenase activity
TREPR_0409	COG3012	SEC-C Motif Domain Protein
TREPR_0410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TREPR_0417	COG0446	pyridine nucleotide-disulphide oxidoreductase
TREPR_0417	COG1902	pentaerythritol trinitrate reductase activity
TREPR_0421	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TREPR_0423	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TREPR_0424	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TREPR_0427	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TREPR_0428	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TREPR_0429	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TREPR_0442	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREPR_0446	COG2272	Belongs to the type-B carboxylesterase lipase family
TREPR_0447	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TREPR_0448	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TREPR_0449	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TREPR_0450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TREPR_0451	COG2197	response regulator
TREPR_0452	COG0084	hydrolase, TatD family'
TREPR_0453	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TREPR_0453	COG3116	cell division
TREPR_0454	COG3706	GGDEF domain
TREPR_0456	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TREPR_0460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TREPR_0463	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_0464	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_0465	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TREPR_0465	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TREPR_0466	COG1447	Phosphotransferase system cellobiose-specific component IIA
TREPR_0467	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TREPR_0468	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TREPR_0469	COG2365	Tyrosine phosphatase family
TREPR_0470	COG2723	6-phospho-beta-galactosidase activity
TREPR_0471	COG0363	glucosamine-6-phosphate deaminase activity
TREPR_0472	COG0243	molybdopterin cofactor binding
TREPR_0473	COG0006	proline dipeptidase activity
TREPR_0476	COG4608	Belongs to the ABC transporter superfamily
TREPR_0477	COG0444	Belongs to the ABC transporter superfamily
TREPR_0478	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_0483	COG0072	phenylalanine-tRNA ligase activity
TREPR_0489	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREPR_0489	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TREPR_0489	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_0490	COG0598	Magnesium transport protein CorA
TREPR_0491	COG0009	L-threonylcarbamoyladenylate synthase
TREPR_0493	COG0840	transmembrane signaling receptor activity
TREPR_0494	COG0840	transmembrane signaling receptor activity
TREPR_0495	COG0840	transmembrane signaling receptor activity
TREPR_0497	COG1309	transcriptional regulator
TREPR_0498	COG0116	Belongs to the methyltransferase superfamily
TREPR_0499	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TREPR_0502	COG1847	R3H domain protein
TREPR_0503	COG0706	membrane insertase activity
TREPR_0505	COG0594	ribonuclease P activity
TREPR_0506	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TREPR_0512	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TREPR_0513	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TREPR_0518	COG4771	TonB-dependent receptor
TREPR_0521	COG2875	Belongs to the precorrin methyltransferase family
TREPR_0526	COG1797	cobyrinic acid a,c-diamide synthase activity
TREPR_0528	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TREPR_0531	COG2082	Precorrin-8x methylmutase
TREPR_0532	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREPR_0533	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TREPR_0534	COG1492	cobalamin metabolic process
TREPR_0539	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREPR_0540	COG1120	ATPase activity
TREPR_0541	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TREPR_0545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TREPR_0546	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TREPR_0553	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TREPR_0556	COG0488	(ABC) transporter
TREPR_0560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TREPR_0561	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TREPR_0562	COG0110	maltose O-acetyltransferase activity
TREPR_0566	COG1509	lysine 2,3-aminomutase activity
TREPR_0567	COG3842	ATPase activity
TREPR_0568	COG1176	ABC-type spermidine putrescine transport system, permease component I
TREPR_0569	COG1177	transmembrane transport
TREPR_0570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TREPR_0572	COG0037	tRNA processing
TREPR_0573	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TREPR_0581	COG2205	protein histidine kinase activity
TREPR_0583	COG2608	mercury ion transmembrane transporter activity
TREPR_0584	COG2217	Heavy metal translocating P-type atpase
TREPR_0587	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREPR_0588	COG0800	Aldolase
TREPR_0589	COG1904	glucuronate isomerase
TREPR_0591	COG1312	Catalyzes the dehydration of D-mannonate
TREPR_0592	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TREPR_0595	COG1802	Transcriptional regulator
TREPR_0596	COG0459	protein refolding
TREPR_0598	COG0328	RNA-DNA hybrid ribonuclease activity
TREPR_0599	COG4443	Transcriptional Coactivator p15 (PC4)
TREPR_0606	COG1487	ribonuclease activity
TREPR_0607	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TREPR_0608	COG0205	6-phosphofructokinase activity
TREPR_0612	COG0105	UTP biosynthetic process
TREPR_0614	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TREPR_0615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TREPR_0616	COG0784	Response regulator, receiver
TREPR_0616	COG2198	Histidine kinase
TREPR_0616	COG2205	protein histidine kinase activity
TREPR_0625	COG1051	belongs to the nudix hydrolase family
TREPR_0627	COG1918	ferrous iron import across plasma membrane
TREPR_0627	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TREPR_0629	COG0626	cystathionine gamma-synthase activity
TREPR_0630	COG0626	cystathionine gamma-synthase activity
TREPR_0632	COG1959	2 iron, 2 sulfur cluster binding
TREPR_0634	COG0436	Aminotransferase
TREPR_0636	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TREPR_0638	COG0542	response to heat
TREPR_0639	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TREPR_0640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TREPR_0648	COG0556	nucleotide-excision repair
TREPR_0655	COG1070	Carbohydrate kinase
TREPR_0659	COG3842	ATPase activity
TREPR_0663	COG0442	prolyl-tRNA aminoacylation
TREPR_0668	COG0248	Ppx GppA phosphatase
TREPR_0669	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TREPR_0670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TREPR_0672	COG0601	transmembrane transport
TREPR_0674	COG0444	Belongs to the ABC transporter superfamily
TREPR_0675	COG4608	Belongs to the ABC transporter superfamily
TREPR_0681	COG0475	glutathione-regulated potassium exporter activity
TREPR_0685	COG5000	phosphorelay sensor kinase activity
TREPR_0686	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_0687	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TREPR_0692	COG1078	dGTPase activity
TREPR_0698	COG0784	Response regulator, receiver
TREPR_0698	COG2198	Histidine kinase
TREPR_0698	COG5002	protein histidine kinase activity
TREPR_0699	COG0840	transmembrane signaling receptor activity
TREPR_0700	COG0673	inositol 2-dehydrogenase activity
TREPR_0705	COG0444	Belongs to the ABC transporter superfamily
TREPR_0706	COG4608	Belongs to the ABC transporter superfamily
TREPR_0707	COG0747	negative chemotaxis
TREPR_0711	COG0446	pyridine nucleotide-disulphide oxidoreductase
TREPR_0714	COG0739	heme binding
TREPR_0714	COG0741	lytic transglycosylase activity
TREPR_0714	COG1196	nuclear chromosome segregation
TREPR_0716	COG0142	geranyltranstransferase activity
TREPR_0717	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TREPR_0720	COG0656	L-ascorbic acid biosynthetic process
TREPR_0723	COG0765	amino acid transport
TREPR_0726	COG1132	(ABC) transporter
TREPR_0727	COG4211	Belongs to the binding-protein-dependent transport system permease family
TREPR_0730	COG0420	3'-5' exonuclease activity
TREPR_0731	COG0419	ATPase involved in DNA repair
TREPR_0733	COG0534	Mate efflux family protein
TREPR_0735	COG0423	glycine-tRNA ligase activity
TREPR_0738	COG2801	Transposase and inactivated derivatives
TREPR_0744	COG1959	2 iron, 2 sulfur cluster binding
TREPR_0747	COG4399	Belongs to the UPF0754 family
TREPR_0749	COG0210	DNA helicase
TREPR_0755	COG5012	cobalamin binding
TREPR_0758	COG4864	UPF0365 protein
TREPR_0764	COG0724	RNA recognition motif
TREPR_0765	COG1639	'signal transduction protein
TREPR_0767	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TREPR_0768	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TREPR_0773	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TREPR_0774	COG3657	addiction module killer protein
TREPR_0776	COG0148	phosphopyruvate hydratase activity
TREPR_0779	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TREPR_0781	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TREPR_0796	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TREPR_0797	COG1687	branched-chain amino acid
TREPR_0798	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TREPR_0799	COG2078	PFAM AMMECR1 domain protein
TREPR_0800	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
TREPR_0801	COG0546	phosphoglycolate phosphatase activity
TREPR_0802	COG0534	Mate efflux family protein
TREPR_0808	COG0714	Associated with various cellular activities
TREPR_0817	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TREPR_0825	COG0601	transmembrane transport
TREPR_0826	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_0827	COG0444	Belongs to the ABC transporter superfamily
TREPR_0829	COG1362	aminopeptidase activity
TREPR_0830	COG0747	negative chemotaxis
TREPR_0833	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TREPR_0836	COG0626	cystathionine gamma-synthase activity
TREPR_0839	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
TREPR_0843	COG1733	regulation of RNA biosynthetic process
TREPR_0848	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TREPR_0850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TREPR_0851	COG2843	Capsule synthesis protein
TREPR_0854	COG0563	adenylate kinase activity
TREPR_0859	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TREPR_0864	COG1943	Transposase
TREPR_0898	COG2003	Belongs to the UPF0758 family
TREPR_0900	COG1122	ATPase activity
TREPR_0901	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TREPR_0904	COG0587	DNA-directed DNA polymerase activity
TREPR_0912	COG1475	DNA binding
TREPR_0921	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TREPR_0924	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TREPR_0925	COG0250	Participates in transcription elongation, termination and antitermination
TREPR_0926	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TREPR_0927	COG0081	regulation of translation
TREPR_0928	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TREPR_0929	COG0222	ribosome binding
TREPR_0930	COG0085	RNA polymerase activity
TREPR_0931	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TREPR_0932	COG4608	Belongs to the ABC transporter superfamily
TREPR_0933	COG0444	Belongs to the ABC transporter superfamily
TREPR_0934	COG0601	transmembrane transport
TREPR_0936	COG0747	negative chemotaxis
TREPR_0937	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TREPR_0938	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
TREPR_0939	COG0006	proline dipeptidase activity
TREPR_0953	COG1126	abc transporter atp-binding protein
TREPR_0954	COG0765	amino acid transport
TREPR_0955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_0957	COG0243	molybdopterin cofactor binding
TREPR_0959	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_0962	COG1126	abc transporter atp-binding protein
TREPR_0963	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_0964	COG0765	amino acid transport
TREPR_0965	COG0765	amino acid transport
TREPR_0966	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TREPR_0970	COG1966	Carbon starvation protein
TREPR_0971	COG5341	Protein conserved in bacteria
TREPR_0974	COG1477	protein flavinylation
TREPR_0976	COG0028	Belongs to the TPP enzyme family
TREPR_0979	COG0473	3-isopropylmalate dehydrogenase activity
TREPR_0980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREPR_0982	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TREPR_0983	COG0440	acetolactate synthase activity
TREPR_0986	COG2199	diguanylate cyclase activity
TREPR_0986	COG2203	Gaf domain
TREPR_0988	COG0825	malonyl-CoA metabolic process
TREPR_0989	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TREPR_0998	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TREPR_1001	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TREPR_1001	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TREPR_1005	COG2508	Transcriptional regulator
TREPR_1011	COG3328	transposase activity
TREPR_1019	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TREPR_1021	COG0534	Mate efflux family protein
TREPR_1023	COG1329	Transcriptional regulator
TREPR_1025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TREPR_1026	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TREPR_1030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TREPR_1033	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TREPR_1050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TREPR_1054	COG5002	protein histidine kinase activity
TREPR_1054	COG2205	protein histidine kinase activity
TREPR_1054	COG0784	Response regulator, receiver
TREPR_1055	COG0564	pseudouridine synthase activity
TREPR_1058	COG1489	DNA binding
TREPR_1061	COG1584	GPR1 FUN34 yaaH family protein
TREPR_1062	COG0606	chelatase, subunit chli
TREPR_1063	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TREPR_1066	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TREPR_1067	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TREPR_1069	COG0012	GTP binding
TREPR_1070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TREPR_1075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TREPR_1076	COG0537	adenosine 5'-monophosphoramidase activity
TREPR_1078	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TREPR_1079	COG0445	tRNA wobble uridine modification
TREPR_1080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TREPR_1081	COG0671	phosphoesterase, PA-phosphatase related
TREPR_1085	COG0191	fructose-bisphosphate aldolase activity
TREPR_1101	COG0322	excinuclease ABC activity
TREPR_1104	COG1639	'signal transduction protein
TREPR_1105	COG1234	tRNA 3'-trailer cleavage
TREPR_1107	COG0006	proline dipeptidase activity
TREPR_1116	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TREPR_1117	COG0662	Cupin 2, conserved barrel domain protein
TREPR_1118	COG0668	transmembrane transport
TREPR_1122	COG0683	leucine binding
TREPR_1123	COG0559	Belongs to the binding-protein-dependent transport system permease family
TREPR_1125	COG0411	ABC transporter
TREPR_1126	COG0410	ABC transporter
TREPR_1127	COG0517	IMP dehydrogenase activity
TREPR_1128	COG1120	ATPase activity
TREPR_1140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TREPR_1141	COG1136	(ABC) transporter
TREPR_1143	COG1910	domain protein
TREPR_1148	COG1269	ATP hydrolysis coupled proton transport
TREPR_1152	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TREPR_1153	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TREPR_1166	COG1811	Na channel or pump
TREPR_1169	COG0564	pseudouridine synthase activity
TREPR_1170	COG1472	Belongs to the glycosyl hydrolase 3 family
TREPR_1172	COG1355	regulation of microtubule-based process
TREPR_1173	COG1022	Amp-dependent synthetase and ligase
TREPR_1176	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TREPR_1177	COG0662	Cupin 2, conserved barrel domain protein
TREPR_1177	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TREPR_1179	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TREPR_1182	COG0514	ATP-dependent DNA helicase (RecQ)
TREPR_1183	COG1487	ribonuclease activity
TREPR_1185	COG0436	Aminotransferase
TREPR_1193	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREPR_1199	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TREPR_1202	COG0037	tRNA processing
TREPR_1203	COG1846	Transcriptional regulator
TREPR_1205	COG2814	Major facilitator Superfamily
TREPR_1206	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TREPR_1209	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TREPR_1211	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TREPR_1214	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TREPR_1215	COG1394	ATPase activity, coupled to movement of substances
TREPR_1218	COG0484	heat shock protein binding
TREPR_1219	COG0024	Methionine aminopeptidase
TREPR_1220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TREPR_1221	COG2089	acid synthase
TREPR_1224	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TREPR_1226	COG0521	Mo-molybdopterin cofactor biosynthetic process
TREPR_1228	COG0626	cystathionine gamma-synthase activity
TREPR_1231	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TREPR_1232	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TREPR_1233	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TREPR_1234	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TREPR_1236	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TREPR_1251	COG3437	response regulator, receiver
TREPR_1251	COG2205	protein histidine kinase activity
TREPR_1251	COG3850	Histidine kinase
TREPR_1251	COG4999	Histidine kinase
TREPR_1254	COG0784	Response regulator, receiver
TREPR_1254	COG2205	protein histidine kinase activity
TREPR_1254	COG5002	protein histidine kinase activity
TREPR_1255	COG2205	protein histidine kinase activity
TREPR_1255	COG5002	protein histidine kinase activity
TREPR_1255	COG0784	Response regulator, receiver
TREPR_1260	COG2198	Histidine kinase
TREPR_1260	COG5002	protein histidine kinase activity
TREPR_1260	COG0784	Response regulator, receiver
TREPR_1265	COG2086	electron transfer activity
TREPR_1266	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TREPR_1268	COG0825	malonyl-CoA metabolic process
TREPR_1269	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TREPR_1270	COG0439	Biotin carboxylase
TREPR_1271	COG0511	ligase activity, forming carbon-carbon bonds
TREPR_1276	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TREPR_1277	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TREPR_1279	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TREPR_1280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TREPR_1281	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TREPR_1284	COG1473	amidohydrolase
TREPR_1286	COG3052	prosthetic group binding
TREPR_1287	COG2301	Belongs to the HpcH HpaI aldolase family
TREPR_1299	COG1473	amidohydrolase
TREPR_1306	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TREPR_1309	COG2084	Dehydrogenase
TREPR_1310	COG3958	Transketolase
TREPR_1311	COG3959	Transketolase, thiamine diphosphate binding domain
TREPR_1315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TREPR_1316	COG1082	Xylose isomerase domain protein TIM barrel
TREPR_1317	COG2186	Transcriptional regulator
TREPR_1321	COG2267	carboxylic ester hydrolase activity
TREPR_1323	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TREPR_1324	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREPR_1332	COG0747	negative chemotaxis
TREPR_1333	COG0601	transmembrane transport
TREPR_1337	COG2272	Belongs to the type-B carboxylesterase lipase family
TREPR_1340	COG0321	lipoyl(octanoyl) transferase activity
TREPR_1340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TREPR_1345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TREPR_1345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TREPR_1350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TREPR_1350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TREPR_1353	COG1126	abc transporter atp-binding protein
TREPR_1354	COG0765	amino acid transport
TREPR_1355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_1356	COG0561	phosphatase activity
TREPR_1357	COG0737	Belongs to the 5'-nucleotidase family
TREPR_1360	COG5012	cobalamin binding
TREPR_1362	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TREPR_1364	COG3804	dihydrodipicolinate reductase
TREPR_1365	COG3457	Alanine racemase
TREPR_1366	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TREPR_1368	COG0564	pseudouridine synthase activity
TREPR_1369	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TREPR_1372	COG4948	Mandelate Racemase Muconate Lactonizing
TREPR_1373	COG4608	Belongs to the ABC transporter superfamily
TREPR_1374	COG0444	Belongs to the ABC transporter superfamily
TREPR_1377	COG0747	negative chemotaxis
TREPR_1379	COG1132	(ABC) transporter
TREPR_1383	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TREPR_1397	COG4796	Type ii and iii secretion system protein
TREPR_1401	COG0561	phosphatase activity
TREPR_1406	COG3093	addiction module antidote protein HigA
TREPR_1420	COG0546	phosphoglycolate phosphatase activity
TREPR_1439	COG4115	mRNA cleavage
TREPR_1443	COG1175	transmembrane transport
TREPR_1449	COG0672	)-iron permease
TREPR_1450	COG3470	protein probably involved in high-affinity Fe2 transport
TREPR_1453	COG0577	efflux transmembrane transporter activity
TREPR_1453	COG1136	(ABC) transporter
TREPR_1454	COG1136	(ABC) transporter
TREPR_1457	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TREPR_1459	COG1164	Oligoendopeptidase f
TREPR_1465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TREPR_1466	COG1177	transmembrane transport
TREPR_1467	COG1176	ABC-type spermidine putrescine transport system, permease component I
TREPR_1468	COG3842	ATPase activity
TREPR_1471	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TREPR_1472	COG0049	tRNA binding
TREPR_1475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TREPR_1476	COG0051	transcription antitermination factor activity, RNA binding
TREPR_1477	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TREPR_1478	COG0088	Forms part of the polypeptide exit tunnel
TREPR_1479	COG0089	rRNA binding
TREPR_1480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TREPR_1481	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TREPR_1482	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TREPR_1483	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TREPR_1484	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TREPR_1485	COG0255	Belongs to the universal ribosomal protein uL29 family
TREPR_1486	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TREPR_1487	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TREPR_1488	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TREPR_1491	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TREPR_1492	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TREPR_1493	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TREPR_1494	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TREPR_1495	COG1841	ribosomal large subunit assembly
TREPR_1496	COG0200	Binds to the 23S rRNA
TREPR_1498	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TREPR_1499	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TREPR_1500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TREPR_1501	COG0202	RNA polymerase activity
TREPR_1502	COG0203	ribosomal protein L17
TREPR_1504	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TREPR_1505	COG2890	protein-(glutamine-N5) methyltransferase activity
TREPR_1506	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TREPR_1509	COG3842	ATPase activity
TREPR_1510	COG1178	ABC-type Fe3 transport system permease component
TREPR_1511	COG1840	ABC-type Fe3 transport system, periplasmic component
TREPR_1512	COG1486	melibiose metabolic process
TREPR_1514	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREPR_1519	COG1129	ABC transporter
TREPR_1520	COG1172	Belongs to the binding-protein-dependent transport system permease family
TREPR_1521	COG1879	ABC-type sugar transport system periplasmic component
TREPR_1523	COG0488	(ABC) transporter
TREPR_1527	COG1177	transmembrane transport
TREPR_1528	COG3842	ATPase activity
TREPR_1529	COG1660	Displays ATPase and GTPase activities
TREPR_1530	COG4608	Belongs to the ABC transporter superfamily
TREPR_1532	COG0601	transmembrane transport
TREPR_1542	COG1592	Rubrerythrin
TREPR_1545	COG1862	Preprotein translocase
TREPR_1546	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TREPR_1547	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TREPR_1548	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TREPR_1549	COG3835	regulator
TREPR_1555	COG5012	cobalamin binding
TREPR_1559	COG2814	Major facilitator Superfamily
TREPR_1561	COG0583	DNA-binding transcription factor activity
TREPR_1569	COG0534	Mate efflux family protein
TREPR_1570	COG0525	valine-tRNA ligase activity
TREPR_1573	COG2814	Major facilitator Superfamily
TREPR_1574	COG2770	Histidine kinase
TREPR_1574	COG2208	phosphoserine phosphatase activity
TREPR_1575	COG0655	NAD(P)H dehydrogenase (quinone) activity
TREPR_1579	COG0741	lytic transglycosylase activity
TREPR_1579	COG1196	nuclear chromosome segregation
TREPR_1579	COG0739	heme binding
TREPR_1582	COG0431	NADPH-dependent FMN reductase
TREPR_1584	COG1475	DNA binding
TREPR_1586	COG0784	Response regulator, receiver
TREPR_1586	COG2205	protein histidine kinase activity
TREPR_1587	COG2272	Belongs to the type-B carboxylesterase lipase family
TREPR_1588	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREPR_1605	COG2723	6-phospho-beta-galactosidase activity
TREPR_1607	COG4989	oxidoreductase activity
TREPR_1612	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TREPR_1614	COG2186	Transcriptional regulator
TREPR_1619	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TREPR_1620	COG0514	ATP-dependent DNA helicase (RecQ)
TREPR_1621	COG0205	6-phosphofructokinase activity
TREPR_1622	COG0528	UMP kinase activity
TREPR_1623	COG1305	Transglutaminase-like
TREPR_1627	COG0215	cysteine-tRNA ligase activity
TREPR_1628	COG1215	transferase activity, transferring glycosyl groups
TREPR_1635	COG0066	3-isopropylmalate dehydratase activity
TREPR_1645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TREPR_1646	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TREPR_1647	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TREPR_1649	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TREPR_1651	COG1671	Belongs to the UPF0178 family
TREPR_1652	COG0784	Response regulator, receiver
TREPR_1652	COG3437	response regulator, receiver
TREPR_1653	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TREPR_1657	COG0840	transmembrane signaling receptor activity
TREPR_1659	COG2201	protein-glutamate methylesterase activity
TREPR_1664	COG0840	transmembrane signaling receptor activity
TREPR_1666	COG1136	(ABC) transporter
TREPR_1670	COG1120	ATPase activity
TREPR_1675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TREPR_1681	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TREPR_1685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TREPR_1686	COG1702	phosphate starvation-inducible protein PhoH
TREPR_1687	COG1480	7TM receptor with intracellular HD hydrolase
TREPR_1688	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TREPR_1695	COG4120	Belongs to the binding-protein-dependent transport system permease family
TREPR_1696	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TREPR_1696	COG1116	anion transmembrane transporter activity
TREPR_1700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREPR_1703	COG2221	Nitrite and sulphite reductase 4Fe-4S
TREPR_1704	COG3437	response regulator, receiver
TREPR_1705	COG0840	transmembrane signaling receptor activity
TREPR_1708	COG2182	Extracellular solute-binding protein
TREPR_1710	COG0784	Response regulator, receiver
TREPR_1710	COG2205	protein histidine kinase activity
TREPR_1710	COG5002	protein histidine kinase activity
TREPR_1715	COG0343	queuine tRNA-ribosyltransferase activity
TREPR_1717	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TREPR_1717	COG1747	RNA polymerase binding
TREPR_1719	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TREPR_1722	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TREPR_1723	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TREPR_1727	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TREPR_1730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREPR_1735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TREPR_1737	COG0617	tRNA 3'-terminal CCA addition
TREPR_1742	COG0737	Belongs to the 5'-nucleotidase family
TREPR_1743	COG0564	pseudouridine synthase activity
TREPR_1747	COG4658	electron transport chain
TREPR_1750	COG4657	Part of a membrane complex involved in electron transport
TREPR_1751	COG1449	Belongs to the glycosyl hydrolase 57 family
TREPR_1756	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TREPR_1757	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TREPR_1760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TREPR_1761	COG1185	polyribonucleotide nucleotidyltransferase activity
TREPR_1762	COG0756	dUTP diphosphatase activity
TREPR_1766	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TREPR_1768	COG0552	protein localization to endoplasmic reticulum
TREPR_1771	COG1136	(ABC) transporter
TREPR_1773	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TREPR_1775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TREPR_1779	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_1779	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_1779	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_1782	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TREPR_1783	COG0006	proline dipeptidase activity
TREPR_1784	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_1785	COG0601	transmembrane transport
TREPR_1786	COG4608	Belongs to the ABC transporter superfamily
TREPR_1787	COG0444	Belongs to the ABC transporter superfamily
TREPR_1789	COG0564	pseudouridine synthase activity
TREPR_1794	COG1373	ATPase (AAA superfamily
TREPR_1795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TREPR_1795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TREPR_1798	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TREPR_1800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TREPR_1802	COG0295	cytidine deaminase activity
TREPR_1805	COG2379	hydroxypyruvate reductase
TREPR_1808	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TREPR_1809	COG2255	four-way junction helicase activity
TREPR_1827	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREPR_1829	COG0632	four-way junction helicase activity
TREPR_1832	COG1205	dead DEAH box helicase
TREPR_1832	COG1111	helicase
TREPR_1834	COG0542	response to heat
TREPR_1836	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TREPR_1839	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_1839	COG0574	Belongs to the PEP-utilizing enzyme family
TREPR_1841	COG0280	phosphate acetyltransferase
TREPR_1844	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TREPR_1846	COG2116	formate transmembrane transporter activity
TREPR_1860	COG2197	response regulator
TREPR_1903	COG2801	Transposase and inactivated derivatives
TREPR_1920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TREPR_1921	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TREPR_1922	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TREPR_1923	COG3437	response regulator, receiver
TREPR_1923	COG2770	Histidine kinase
TREPR_1924	COG1214	PFAM Peptidase M22, glycoprotease
TREPR_1925	COG0802	atpase or kinase
TREPR_1935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TREPR_1936	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TREPR_1938	COG0736	holo-[acyl-carrier-protein] synthase activity
TREPR_1940	COG0101	tRNA pseudouridine synthase activity
TREPR_1941	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TREPR_1941	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TREPR_1942	COG1321	iron dependent repressor
TREPR_1943	COG0698	ribose 5-phosphate isomerase
TREPR_1945	COG0268	Binds directly to 16S ribosomal RNA
TREPR_1946	COG0776	regulation of translation
TREPR_1947	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TREPR_1950	COG1546	Belongs to the CinA family
TREPR_1950	COG1058	Belongs to the CinA family
TREPR_1951	COG0740	serine-type endopeptidase activity
TREPR_1955	COG0747	negative chemotaxis
TREPR_1956	COG0601	transmembrane transport
TREPR_1958	COG0444	Belongs to the ABC transporter superfamily
TREPR_1959	COG4608	Belongs to the ABC transporter superfamily
TREPR_1963	COG2801	Transposase and inactivated derivatives
TREPR_1964	COG0789	Transcriptional regulator
TREPR_1965	COG1227	inorganic diphosphatase activity
TREPR_1965	COG0517	IMP dehydrogenase activity
TREPR_1966	COG3345	alpha-galactosidase
TREPR_1967	COG0193	aminoacyl-tRNA hydrolase activity
TREPR_1968	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TREPR_1969	COG3956	TIGRFAM MazG family protein
TREPR_1970	COG1285	pathogenesis
TREPR_1972	COG1609	Transcriptional regulator
TREPR_1974	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TREPR_1982	COG1840	ABC-type Fe3 transport system, periplasmic component
TREPR_1988	COG0438	transferase activity, transferring glycosyl groups
TREPR_1990	COG0674	pyruvate-flavodoxin oxidoreductase activity
TREPR_1990	COG1013	pyruvate-flavodoxin oxidoreductase activity
TREPR_1990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TREPR_1990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TREPR_1995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TREPR_1997	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREPR_2015	COG2197	response regulator
TREPR_2026	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TREPR_2029	COG0587	DNA-directed DNA polymerase activity
TREPR_2064	COG3328	transposase activity
TREPR_2065	COG0494	nUDIX hydrolase
TREPR_2067	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TREPR_2068	COG2205	protein histidine kinase activity
TREPR_2068	COG0784	Response regulator, receiver
TREPR_2072	COG0494	nUDIX hydrolase
TREPR_2073	COG4536	flavin adenine dinucleotide binding
TREPR_2122	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TREPR_2124	COG0297	glycogen (starch) synthase activity
TREPR_2126	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TREPR_2127	COG4608	Belongs to the ABC transporter superfamily
TREPR_2128	COG0444	Belongs to the ABC transporter superfamily
TREPR_2129	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_2130	COG0601	transmembrane transport
TREPR_2137	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TREPR_2145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TREPR_2148	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TREPR_2152	COG1253	flavin adenine dinucleotide binding
TREPR_2157	COG3328	transposase activity
TREPR_2164	COG0500	methyltransferase
TREPR_2176	COG3328	transposase activity
TREPR_2177	COG4221	oxidoreductase activity
TREPR_2206	COG4974	Belongs to the 'phage' integrase family
TREPR_2211	COG0739	heme binding
TREPR_2214	COG1686	Belongs to the peptidase S11 family
TREPR_2215	COG0017	Asparaginyl-tRNA synthetase
TREPR_2218	COG3706	GGDEF domain
TREPR_2220	COG0431	NADPH-dependent FMN reductase
TREPR_2221	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TREPR_2222	COG1286	toxin biosynthetic process
TREPR_2223	COG0470	DNA polymerase III
TREPR_2224	COG2208	phosphoserine phosphatase activity
TREPR_2225	COG1366	Belongs to the anti-sigma-factor antagonist family
TREPR_2227	COG0477	Major facilitator Superfamily
TREPR_2228	COG5002	protein histidine kinase activity
TREPR_2229	COG2204	response regulator
TREPR_2235	COG1872	DUF167
TREPR_2238	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TREPR_2242	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TREPR_2243	COG1162	GTPase activity
TREPR_2244	COG1193	negative regulation of DNA recombination
TREPR_2248	COG1438	arginine binding
TREPR_2249	COG0166	Belongs to the GPI family
TREPR_2255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_2255	COG0574	Belongs to the PEP-utilizing enzyme family
TREPR_2268	COG3328	transposase activity
TREPR_2271	COG1373	ATPase (AAA superfamily
TREPR_2279	COG1196	nuclear chromosome segregation
TREPR_2280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TREPR_2283	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TREPR_2300	COG2197	response regulator
TREPR_2308	COG1595	DNA-templated transcription, initiation
TREPR_2311	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TREPR_2312	COG2169	Transcriptional regulator
TREPR_2318	COG1234	tRNA 3'-trailer cleavage
TREPR_2320	COG0358	DNA primase activity
TREPR_2321	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREPR_2325	COG1077	Cell shape determining protein MreB Mrl
TREPR_2326	COG1792	Involved in formation and maintenance of cell shape
TREPR_2328	COG0768	penicillin binding
TREPR_2329	COG0772	Belongs to the SEDS family
TREPR_2332	COG1464	Belongs to the NlpA lipoprotein family
TREPR_2333	COG2011	ABC-type metal ion transport system permease component
TREPR_2334	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TREPR_2339	COG0539	negative regulation of cytoplasmic translation
TREPR_2342	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TREPR_2344	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TREPR_2347	COG0494	nUDIX hydrolase
TREPR_2352	COG0653	protein targeting
TREPR_2356	COG1086	Polysaccharide biosynthesis protein
TREPR_2357	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TREPR_2362	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TREPR_2365	COG0028	Belongs to the TPP enzyme family
TREPR_2365	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
TREPR_2366	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TREPR_2367	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TREPR_2373	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TREPR_2378	COG0110	maltose O-acetyltransferase activity
TREPR_2382	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TREPR_2386	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_2387	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TREPR_2388	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_2389	COG1216	Glycosyl transferase, family 2
TREPR_2391	COG0463	Glycosyl transferase, family 2
TREPR_2392	COG3328	transposase activity
TREPR_2397	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TREPR_2399	COG0706	membrane insertase activity
TREPR_2402	COG0706	membrane insertase activity
TREPR_2404	COG0706	membrane insertase activity
TREPR_2405	COG0438	transferase activity, transferring glycosyl groups
TREPR_2412	COG1102	Psort location Cytoplasmic, score
TREPR_2413	COG1561	YicC-like family, N-terminal region
TREPR_2414	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TREPR_2415	COG0564	pseudouridine synthase activity
TREPR_2423	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TREPR_2427	COG1363	Peptidase, m42
TREPR_2428	COG4608	Belongs to the ABC transporter superfamily
TREPR_2429	COG0444	Belongs to the ABC transporter superfamily
TREPR_2431	COG0601	transmembrane transport
TREPR_2441	COG2226	methyltransferase
TREPR_2443	COG2610	gluconate transmembrane transporter activity
TREPR_2444	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TREPR_2447	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREPR_2450	COG0372	Belongs to the citrate synthase family
TREPR_2452	COG0149	triose-phosphate isomerase activity
TREPR_2453	COG0126	phosphoglycerate kinase activity
TREPR_2454	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TREPR_2456	COG3437	response regulator, receiver
TREPR_2457	COG2357	RelA SpoT domain protein
TREPR_2460	COG0860	N-Acetylmuramoyl-L-alanine amidase
TREPR_2461	COG1181	Belongs to the D-alanine--D-alanine ligase family
TREPR_2465	COG0731	radical SAM domain protein
TREPR_2466	COG1570	exodeoxyribonuclease VII activity
TREPR_2467	COG1722	exodeoxyribonuclease VII activity
TREPR_2468	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TREPR_2469	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREPR_2470	COG1388	LysM domain
TREPR_2470	COG1705	Flagellar rod assembly protein muramidase FlgJ
TREPR_2483	COG2197	response regulator
TREPR_2485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TREPR_2488	COG0681	Belongs to the peptidase S26 family
TREPR_2489	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TREPR_2490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TREPR_2497	COG2115	Belongs to the xylose isomerase family
TREPR_2498	COG1070	Carbohydrate kinase
TREPR_2504	COG1131	(ABC) transporter
TREPR_2505	COG1234	tRNA 3'-trailer cleavage
TREPR_2508	COG1175	transmembrane transport
TREPR_2509	COG0395	ABC-type sugar transport system, permease component
TREPR_2511	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TREPR_2515	COG0330	HflC and HflK could
TREPR_2516	COG0330	HflC and HflK could
TREPR_2523	COG4953	penicillin-binding protein 1C
TREPR_2528	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TREPR_2531	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TREPR_2533	COG0562	UDP-galactopyranose mutase
TREPR_2535	COG1215	transferase activity, transferring glycosyl groups
TREPR_2540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TREPR_2541	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
TREPR_2542	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
TREPR_2545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TREPR_2546	COG1136	(ABC) transporter
TREPR_2551	COG1116	anion transmembrane transporter activity
TREPR_2555	COG1157	protein secretion by the type III secretion system
TREPR_2556	COG1317	bacterial-type flagellum organization
TREPR_2558	COG1766	The M ring may be actively involved in energy transduction
TREPR_2559	COG1677	Flagellar hook-basal body complex protein FliE
TREPR_2561	COG1815	bacterial-type flagellum-dependent cell motility
TREPR_2562	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TREPR_2563	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TREPR_2564	COG4974	Belongs to the 'phage' integrase family
TREPR_2565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TREPR_2565	COG0551	DNA topoisomerase type I activity
TREPR_2566	COG0758	DNA mediated transformation
TREPR_2568	COG4974	Belongs to the 'phage' integrase family
TREPR_2572	COG0772	Belongs to the SEDS family
TREPR_2573	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TREPR_2575	COG0275	rRNA processing
TREPR_2576	COG2001	Belongs to the MraZ family
TREPR_2579	COG0254	rRNA binding
TREPR_2580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TREPR_2582	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TREPR_2598	COG0544	peptidyl-prolyl cis-trans isomerase activity
TREPR_2599	COG0740	serine-type endopeptidase activity
TREPR_2600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TREPR_2602	COG0438	transferase activity, transferring glycosyl groups
TREPR_2603	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TREPR_2604	COG1573	uracil-dna glycosylase
TREPR_2605	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TREPR_2608	COG1199	ATP-dependent helicase activity
TREPR_2619	COG4115	mRNA cleavage
TREPR_2621	COG2848	UPF0210 protein
TREPR_2622	COG3830	Belongs to the UPF0237 family
TREPR_2627	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TREPR_2630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TREPR_2632	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TREPR_2634	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TREPR_2639	COG1643	Atp-dependent helicase
TREPR_2640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TREPR_2641	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TREPR_2647	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TREPR_2651	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TREPR_2653	COG1269	ATP hydrolysis coupled proton transport
TREPR_2654	COG1394	ATPase activity, coupled to movement of substances
TREPR_2655	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TREPR_2656	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TREPR_2658	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TREPR_2660	COG2017	converts alpha-aldose to the beta-anomer
TREPR_2661	COG0538	isocitrate dehydrogenase activity
TREPR_2666	COG1132	(ABC) transporter
TREPR_2667	COG1132	(ABC) transporter
TREPR_2669	COG0424	maF-like protein
TREPR_2670	COG0052	Belongs to the universal ribosomal protein uS2 family
TREPR_2671	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TREPR_2672	COG0233	cytoplasmic translational termination
TREPR_2673	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TREPR_2674	COG0575	Belongs to the CDS family
TREPR_2675	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TREPR_2677	COG0750	zinc metalloprotease
TREPR_2680	COG0305	Participates in initiation and elongation during chromosome replication
TREPR_2681	COG0359	binds to the 23S rRNA
TREPR_2683	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TREPR_2684	COG0629	single-stranded DNA binding
TREPR_2685	COG0360	Binds together with S18 to 16S ribosomal RNA
TREPR_2687	COG0617	tRNA 3'-terminal CCA addition
TREPR_2689	COG0571	ribonuclease III activity
TREPR_2690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TREPR_2691	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TREPR_2693	COG1413	lyase activity
TREPR_2696	COG0124	histidyl-tRNA synthetase
TREPR_2697	COG0436	Aminotransferase
TREPR_2704	COG0745	RESPONSE REGULATOR receiver
TREPR_2705	COG5002	protein histidine kinase activity
TREPR_2707	COG1846	Transcriptional regulator
TREPR_2708	COG1959	2 iron, 2 sulfur cluster binding
TREPR_2710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TREPR_2724	COG1104	cysteine desulfurase activity
TREPR_2728	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TREPR_2733	COG0840	transmembrane signaling receptor activity
TREPR_2734	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TREPR_2739	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TREPR_2740	COG1373	ATPase (AAA superfamily
TREPR_2744	COG0534	Mate efflux family protein
TREPR_2749	COG0105	UTP biosynthetic process
TREPR_2750	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TREPR_2751	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TREPR_2754	COG1475	DNA binding
TREPR_2755	COG1192	Involved in chromosome partitioning
TREPR_2756	COG0561	phosphatase activity
TREPR_2757	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TREPR_2759	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TREPR_2763	COG1692	metallophosphoesterase
TREPR_2765	COG0693	protein deglycase activity
TREPR_2770	COG2211	Major facilitator Superfamily
TREPR_2792	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TREPR_2794	COG1104	cysteine desulfurase activity
TREPR_2795	COG0301	tRNA thio-modification
TREPR_2800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TREPR_2801	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TREPR_2806	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TREPR_2807	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TREPR_2811	COG0708	Exodeoxyribonuclease III
TREPR_2812	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TREPR_2813	COG0542	response to heat
TREPR_2814	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TREPR_2816	COG1362	aminopeptidase activity
TREPR_2817	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TREPR_2819	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TREPR_2823	COG0534	Mate efflux family protein
TREPR_2827	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TREPR_2838	COG0494	nUDIX hydrolase
TREPR_2839	COG0737	Belongs to the 5'-nucleotidase family
TREPR_2845	COG1191	sigma factor activity
TREPR_2847	COG0455	bacterial-type flagellum organization
TREPR_2850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TREPR_2851	COG1684	flagellar biosynthetic protein fliR
TREPR_2852	COG1987	bacterial-type flagellum assembly
TREPR_2853	COG1338	Plays a role in the flagellum-specific transport system
TREPR_2855	COG1776	CheC inhibitor of MCP methylation
TREPR_2855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TREPR_2856	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TREPR_2858	COG1580	Controls the rotational direction of flagella during chemotaxis
TREPR_2860	COG1360	Flagellar Motor Protein
TREPR_2864	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TREPR_2872	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TREPR_2876	COG0641	radical SAM
TREPR_2878	COG1546	Belongs to the CinA family
TREPR_2878	COG1058	Belongs to the CinA family
TREPR_2880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TREPR_2883	COG1433	Dinitrogenase iron-molybdenum cofactor
TREPR_2883	COG0535	radical SAM domain protein
TREPR_2889	COG0347	Belongs to the P(II) protein family
TREPR_2890	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TREPR_2900	COG1410	methionine synthase
TREPR_2900	COG0646	methionine synthase
TREPR_2903	COG3437	response regulator, receiver
TREPR_2903	COG4999	Histidine kinase
TREPR_2903	COG3850	Histidine kinase
TREPR_2903	COG2205	protein histidine kinase activity
TREPR_2905	COG5012	cobalamin binding
TREPR_2906	COG3585	molybdate ion transport
TREPR_2907	COG1695	Transcriptional regulator
TREPR_2910	COG0725	ABC transporter, periplasmic molybdate-binding protein
TREPR_2911	COG3858	chitin binding
TREPR_2913	COG5146	pantothenate kinase activity
TREPR_2919	COG1674	ftsk spoiiie
TREPR_2920	COG1196	nuclear chromosome segregation
TREPR_2920	COG0739	heme binding
TREPR_2920	COG0741	lytic transglycosylase activity
TREPR_2921	COG1652	LysM domain
TREPR_2928	COG0840	transmembrane signaling receptor activity
TREPR_2930	COG1132	(ABC) transporter
TREPR_2931	COG1132	(ABC) transporter
TREPR_2933	COG0497	DNA recombination
TREPR_2934	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TREPR_2936	COG0835	chemotaxis
TREPR_2937	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TREPR_2938	COG0217	transcriptional regulatory protein
TREPR_2941	COG0840	transmembrane signaling receptor activity
TREPR_2946	COG0659	secondary active sulfate transmembrane transporter activity
TREPR_2948	COG2217	Heavy metal translocating P-type atpase
TREPR_2950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_2952	COG2723	6-phospho-beta-galactosidase activity
TREPR_2953	COG0737	Belongs to the 5'-nucleotidase family
TREPR_2954	COG2190	(PTS) system
TREPR_2954	COG1263	PTS System
TREPR_2954	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TREPR_2956	COG0561	phosphatase activity
TREPR_2957	COG3711	transcriptional antiterminator
TREPR_2961	COG0251	oxidation-reduction process
TREPR_2963	COG1063	alcohol dehydrogenase
TREPR_2964	COG1105	Belongs to the carbohydrate kinase PfkB family
TREPR_2965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_2968	COG2213	PTS system mannitol-specific
TREPR_2968	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TREPR_2971	COG0835	chemotaxis
TREPR_2972	COG0643	Histidine kinase
TREPR_2972	COG2198	Histidine kinase
TREPR_2973	COG0557	exoribonuclease II activity
TREPR_2974	COG0527	aspartate kinase activity
TREPR_2975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TREPR_2976	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TREPR_2981	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TREPR_2982	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TREPR_2983	COG2137	regulation of response to DNA damage stimulus
TREPR_2984	COG0513	Belongs to the DEAD box helicase family
TREPR_2985	COG4948	Mandelate Racemase Muconate Lactonizing
TREPR_2990	COG1414	Transcriptional regulator
TREPR_2991	COG0800	Aldolase
TREPR_2997	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TREPR_2999	COG4214	carbohydrate transport
TREPR_3001	COG4213	ABC transporter substrate-binding protein
TREPR_3003	COG4213	ABC transporter substrate-binding protein
TREPR_3005	COG2972	Histidine kinase
TREPR_3007	COG0739	heme binding
TREPR_3010	COG1774	PSP1 C-terminal conserved region
TREPR_3011	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TREPR_3012	COG2201	protein-glutamate methylesterase activity
TREPR_3017	COG1137	ATPase activity
TREPR_3018	COG0534	Mate efflux family protein
TREPR_3022	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TREPR_3023	COG0667	Aldo Keto reductase
TREPR_3027	COG4166	transmembrane transport
TREPR_3028	COG0601	transmembrane transport
TREPR_3030	COG0444	Belongs to the ABC transporter superfamily
TREPR_3031	COG4608	Belongs to the ABC transporter superfamily
TREPR_3032	COG1418	mRNA catabolic process
TREPR_3036	COG3842	ATPase activity
TREPR_3037	COG4149	molybdate abc transporter
TREPR_3038	COG3394	polysaccharide catabolic process
TREPR_3039	COG1692	metallophosphoesterase
TREPR_3042	COG0560	Phosphoserine phosphatase
TREPR_3043	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TREPR_3050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TREPR_3051	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TREPR_3053	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
TREPR_3054	COG0156	8-amino-7-oxononanoate synthase activity
TREPR_3056	COG3437	response regulator, receiver
TREPR_3058	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TREPR_3059	COG0840	transmembrane signaling receptor activity
TREPR_3060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TREPR_3060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TREPR_3060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TREPR_3082	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TREPR_3088	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_3089	COG1126	abc transporter atp-binding protein
TREPR_3090	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TREPR_3095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TREPR_3095	COG0493	'glutamate synthase
TREPR_3097	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TREPR_3098	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TREPR_3098	COG0493	'glutamate synthase
TREPR_3099	COG3383	formate dehydrogenase (NAD+) activity
TREPR_3110	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
TREPR_3112	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TREPR_3118	COG4804	nuclease activity
TREPR_3124	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TREPR_3125	COG3404	Formiminotransferase-cyclodeaminase
TREPR_3126	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TREPR_3129	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TREPR_3131	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TREPR_3133	COG0285	dihydrofolate synthase activity
TREPR_3134	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TREPR_3137	COG0237	dephospho-CoA kinase activity
TREPR_3139	COG4166	transmembrane transport
TREPR_3151	COG5002	protein histidine kinase activity
TREPR_3151	COG2198	Histidine kinase
TREPR_3151	COG0784	Response regulator, receiver
TREPR_3153	COG0228	four-way junction DNA binding
TREPR_3155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TREPR_3156	COG0336	Belongs to the RNA methyltransferase TrmD family
TREPR_3157	COG0335	large ribosomal subunit rRNA binding
TREPR_3159	COG2257	FlhB HrpN YscU SpaS Family
TREPR_3161	COG0792	nuclease activity
TREPR_3163	COG0745	RESPONSE REGULATOR receiver
TREPR_3163	COG3706	GGDEF domain
TREPR_3164	COG2197	response regulator
TREPR_3165	COG3851	Histidine kinase
TREPR_3176	COG1854	S-ribosylhomocysteine lyase activity
TREPR_3184	COG1121	(ABC) transporter
TREPR_3185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TREPR_3188	COG1160	GTP binding
TREPR_3189	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TREPR_3196	COG0326	Molecular chaperone. Has ATPase activity
TREPR_3200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TREPR_3203	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TREPR_3204	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TREPR_3205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TREPR_3206	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TREPR_3206	COG0140	phosphoribosyl-ATP diphosphatase activity
TREPR_3207	COG0107	imidazoleglycerol-phosphate synthase activity
TREPR_3210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TREPR_3212	COG0778	Nitroreductase
TREPR_3215	COG1606	tRNA processing
TREPR_3216	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TREPR_3217	COG1691	(AIR) carboxylase
TREPR_3220	COG1178	ABC-type Fe3 transport system permease component
TREPR_3221	COG3842	ATPase activity
TREPR_3226	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TREPR_3228	COG0477	Major facilitator Superfamily
TREPR_3229	COG0495	leucyl-tRNA aminoacylation
TREPR_3233	COG4115	mRNA cleavage
TREPR_3240	COG1346	cytolysis
TREPR_3241	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TREPR_3242	COG0569	domain protein
TREPR_3255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TREPR_3256	COG1193	negative regulation of DNA recombination
TREPR_3264	COG0714	Associated with various cellular activities
TREPR_3266	COG1124	(ABC) transporter
TREPR_3267	COG0444	Belongs to the ABC transporter superfamily
TREPR_3268	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_3269	COG0601	transmembrane transport
TREPR_3270	COG0747	negative chemotaxis
TREPR_3271	COG1120	ATPase activity
TREPR_3272	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREPR_3276	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TREPR_3278	COG2226	methyltransferase
TREPR_3281	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TREPR_3294	COG1122	ATPase activity
TREPR_3297	COG1012	belongs to the aldehyde dehydrogenase family
TREPR_3297	COG1454	alcohol dehydrogenase
TREPR_3305	COG2357	RelA SpoT domain protein
TREPR_3308	COG0484	heat shock protein binding
TREPR_3312	COG0583	DNA-binding transcription factor activity
TREPR_3314	COG3052	prosthetic group binding
TREPR_3316	COG3051	citrate lyase alpha subunit
TREPR_3317	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TREPR_3319	COG2843	Capsule synthesis protein
TREPR_3325	COG0584	glycerophosphoryl diester phosphodiesterase
TREPR_3326	COG1175	transmembrane transport
TREPR_3329	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TREPR_3330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TREPR_3333	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TREPR_3334	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TREPR_3335	COG0655	NAD(P)H dehydrogenase (quinone) activity
TREPR_3337	COG1126	abc transporter atp-binding protein
TREPR_3338	COG0765	amino acid transport
TREPR_3340	COG0765	amino acid transport
TREPR_3343	COG1126	abc transporter atp-binding protein
TREPR_3345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_3346	COG0765	amino acid transport
TREPR_3347	COG2197	response regulator
TREPR_3348	COG4585	Histidine kinase
TREPR_3349	COG1473	amidohydrolase
TREPR_3350	COG0137	argininosuccinate synthase activity
TREPR_3356	COG1487	ribonuclease activity
TREPR_3357	COG0165	Argininosuccinate lyase
TREPR_3358	COG0363	glucosamine-6-phosphate deaminase activity
TREPR_3359	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TREPR_3360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TREPR_3360	COG0426	domain, Protein
TREPR_3361	COG2201	protein-glutamate methylesterase activity
TREPR_3362	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TREPR_3365	COG0667	Aldo Keto reductase
TREPR_3367	COG2003	Belongs to the UPF0758 family
TREPR_3374	COG0673	inositol 2-dehydrogenase activity
TREPR_3378	COG2885	chlorophyll binding
TREPR_3381	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TREPR_3383	COG2059	Chromate
TREPR_3399	COG0481	GTPase activity
TREPR_3402	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TREPR_3403	COG2207	Transcriptional regulator
TREPR_3403	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TREPR_3404	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TREPR_3404	COG2207	Transcriptional regulator
TREPR_3405	COG2197	response regulator
TREPR_3406	COG2197	response regulator
TREPR_3416	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TREPR_3417	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
TREPR_3421	COG0674	pyruvate-flavodoxin oxidoreductase activity
TREPR_3421	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TREPR_3429	COG4702	Belongs to the UPF0303 family
TREPR_3430	COG3706	GGDEF domain
TREPR_3432	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TREPR_3434	COG0791	NLP P60 protein
TREPR_3443	COG0018	arginyl-trna synthetase
TREPR_3444	COG0534	Mate efflux family protein
TREPR_3446	COG1215	transferase activity, transferring glycosyl groups
TREPR_3448	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TREPR_3450	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TREPR_3451	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TREPR_3452	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TREPR_3458	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TREPR_3460	COG0667	Aldo Keto reductase
TREPR_3465	COG1151	hydroxylamine reductase activity
TREPR_3466	COG0067	glutamate synthase
TREPR_3466	COG0070	glutamate synthase
TREPR_3466	COG0069	glutamate synthase activity
TREPR_3468	COG0728	peptidoglycan biosynthetic process
TREPR_3469	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TREPR_3479	COG4786	Flagellar basal body rod
TREPR_3485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TREPR_3490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TREPR_3491	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TREPR_3492	COG1335	isochorismatase
TREPR_3499	COG0543	2 iron, 2 sulfur cluster binding
TREPR_3504	COG2205	protein histidine kinase activity
TREPR_3504	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_3505	COG3437	response regulator, receiver
TREPR_3507	COG2011	ABC-type metal ion transport system permease component
TREPR_3508	COG3118	belongs to the thioredoxin family
TREPR_3512	COG0004	ammonium transporteR
TREPR_3527	COG0084	hydrolase, TatD family'
TREPR_3530	COG0737	Belongs to the 5'-nucleotidase family
TREPR_3531	COG1744	ABC transporter substrate-binding protein PnrA-like
TREPR_3541	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TREPR_3542	COG0601	transmembrane transport
TREPR_3551	COG0205	6-phosphofructokinase activity
TREPR_3554	COG0724	RNA recognition motif
TREPR_3562	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TREPR_3564	COG1115	amino acid carrier protein
TREPR_3565	COG0686	Belongs to the AlaDH PNT family
TREPR_3566	COG1522	sequence-specific DNA binding
TREPR_3567	COG0583	DNA-binding transcription factor activity
TREPR_3569	COG0737	Belongs to the 5'-nucleotidase family
TREPR_3569	COG4085	toxin activity
TREPR_3569	COG1525	nuclease
TREPR_3572	COG0534	Mate efflux family protein
TREPR_3574	COG1373	ATPase (AAA superfamily
TREPR_3577	COG1609	Transcriptional regulator
TREPR_3578	COG1609	Transcriptional regulator
TREPR_3579	COG1129	ABC transporter
TREPR_3589	COG2197	response regulator
TREPR_3593	COG1047	Peptidyl-prolyl cis-trans
TREPR_3600	COG1045	serine acetyltransferase
TREPR_3601	COG1752	Esterase of the alpha-beta hydrolase superfamily
TREPR_3602	COG1063	alcohol dehydrogenase
TREPR_3603	COG1797	cobyrinic acid a,c-diamide synthase activity
TREPR_3606	COG1773	rubredoxin
TREPR_3606	COG1592	Rubrerythrin
TREPR_3612	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREPR_3614	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TREPR_3617	COG1120	ATPase activity
TREPR_3623	COG2176	DNA-directed DNA polymerase activity
TREPR_3629	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TREPR_3637	COG0154	amidase activity
TREPR_3638	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TREPR_3639	COG0017	Asparaginyl-tRNA synthetase
TREPR_3640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TREPR_3642	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TREPR_3654	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TREPR_3661	COG0601	transmembrane transport
TREPR_3662	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TREPR_3663	COG0444	Belongs to the ABC transporter superfamily
TREPR_3664	COG4608	Belongs to the ABC transporter superfamily
TREPR_3668	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TREPR_3672	COG2239	Acts as a magnesium transporter
TREPR_3673	COG1027	Aspartate ammonia-lyase
TREPR_3676	COG1335	isochorismatase
TREPR_3691	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TREPR_3700	COG0084	hydrolase, TatD family'
TREPR_3713	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TREPR_3715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TREPR_3717	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREPR_3718	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TREPR_3719	COG1045	serine acetyltransferase
TREPR_3721	COG0765	amino acid transport
TREPR_3722	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TREPR_3732	COG0438	transferase activity, transferring glycosyl groups
TREPR_3733	COG0110	maltose O-acetyltransferase activity
TREPR_3739	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TREPR_3742	COG1132	(ABC) transporter
TREPR_3747	COG1216	Glycosyl transferase, family 2
TREPR_3756	COG2313	pseudouridylate synthase activity
TREPR_3757	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TREPR_3758	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TREPR_3759	COG1328	CTP reductase activity
TREPR_3771	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TREPR_3774	COG0151	Belongs to the GarS family
TREPR_3777	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TREPR_3780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TREPR_3782	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TREPR_3784	COG1070	Carbohydrate kinase
TREPR_3786	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TREPR_3787	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TREPR_3788	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TREPR_3789	COG0728	peptidoglycan biosynthetic process
TREPR_3792	COG1309	transcriptional regulator
TREPR_3794	COG0357	Ribosomal RNA small subunit methyltransferase G
TREPR_3795	COG2183	response to ionizing radiation
TREPR_3797	COG2887	Belongs to the helicase family. UvrD subfamily
TREPR_3802	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TREPR_3803	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TREPR_3805	COG0488	(ABC) transporter
TREPR_3807	COG1272	protein, Hemolysin III
TREPR_3809	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TREPR_3811	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TREPR_3813	COG0613	PHP domain protein
TREPR_3815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TREPR_3817	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TREPR_3818	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TREPR_3819	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TREPR_3821	COG0587	DNA-directed DNA polymerase activity
TREPR_3829	COG0455	bacterial-type flagellum organization
TREPR_3832	COG1473	amidohydrolase
TREPR_3835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TREPR_3836	COG0095	Lipoate-protein ligase
TREPR_3837	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TREPR_3840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TREPR_3841	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TREPR_3849	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TREPR_3858	COG0492	ferredoxin-NADP+ reductase activity
TREPR_3874	COG1472	Belongs to the glycosyl hydrolase 3 family
TREPR_3876	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TREPR_3877	COG0417	DNA replication proofreading
TREPR_3881	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TREPR_3882	COG0697	spore germination
TREPR_3890	COG2801	Transposase and inactivated derivatives