locus-tag class description JO40_00025 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JO40_00035 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) JO40_00040 ENOG4105C8T Leucyl-tRNA synthetase JO40_00050 ENOG4105DZP Membrane-associated zinc metalloprotease JO40_00055 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) JO40_00060 ENOG4105KNE Phosphatidate cytidylyltransferase JO40_00065 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) JO40_00070 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) JO40_00075 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) JO40_00080 ENOG4105CE9 30S ribosomal protein S2 JO40_00085 ENOG4108Z03 MAF-like protein JO40_00090 ENOG4105SXG JO40_00100 ENOG41069DF JO40_00110 ENOG4105I03 Flagellin JO40_00115 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) JO40_00120 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) JO40_00130 ENOG4105E4C Lytic transglycosylase catalytic JO40_00155 ENOG4105CUY Mechanosensitive ion channel JO40_00175 ENOG4105C8Q Methyl-accepting chemotaxis JO40_00205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO40_00210 ENOG4105C3U ABC transporter JO40_00215 ENOG4108JQ5 ABC transporter JO40_00220 ENOG4105C9B Cysteine desulfurase JO40_00225 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) JO40_00245 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) JO40_00260 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP JO40_00280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO40_00285 ENOG4105C3U ABC transporter JO40_00290 ENOG4108JQ7 (ABC) transporter JO40_00310 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) JO40_00340 ENOG4107QJQ Mate efflux family protein JO40_00345 ENOG4105C8Q Methyl-accepting chemotaxis JO40_00350 ENOG4105DFD Na H antiporter JO40_00365 ENOG4108JUB Transcriptional regulator JO40_00390 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO40_00395 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) JO40_00400 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) JO40_00405 ENOG4105VXR cytoplasmic protein JO40_00415 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) JO40_00425 ENOG4105C28 cystathionine JO40_00435 ENOG4105DFD Na H antiporter JO40_00470 ENOG4108JJB ABC transporter JO40_00530 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 JO40_00555 ENOG4105C9B Cysteine desulfurase JO40_00585 ENOG4105D7N magnesium and cobalt transport protein CorA JO40_00590 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate JO40_00605 ENOG4105VN1 Heat shock protein JO40_00615 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) JO40_00620 ENOG41085YX 50S ribosomal protein L32 JO40_00630 ENOG4107YT1 Glutamate mutase subunit sigma JO40_00640 ENOG41081IW Inherit from COG: Membrane JO40_00650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit JO40_00655 ENOG41071ZZ JO40_00660 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JO40_00665 ENOG4105DAN ATP-dependent protease JO40_00675 ENOG4105W3S hemerythrin-like, metal-binding protein JO40_00690 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) JO40_00695 ENOG41084DP Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JO40_00700 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) JO40_00705 ENOG4105C8Q Methyl-accepting chemotaxis JO40_00705 ENOG4105C8Q Methyl-accepting chemotaxis JO40_00710 ENOG4105BZU Histidine kinase JO40_00725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) JO40_00740 ENOG4105CUZ uba thif-type nad fad binding protein JO40_00745 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) JO40_00750 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO40_00755 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO40_00765 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) JO40_00770 ENOG4108VZM 50s ribosomal protein L10 JO40_00775 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) JO40_00780 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) JO40_00785 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) JO40_00800 ENOG41084ED 50S ribosomal protein L33 JO40_00835 ENOG4108I7Y domain protein JO40_00850 ENOG4105Z8J JO40_00855 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) JO40_00865 ENOG4105C4R Atp-dependent dna helicase JO40_00870 ENOG4105BZ1 (ABC) transporter JO40_00875 ENOG4105BZ1 (ABC) transporter JO40_00880 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) JO40_00900 ENOG4105DBV ornithine carbamoyltransferase JO40_00910 ENOG4105CSM endonuclease III JO40_00915 ENOG4105C8Q Methyl-accepting chemotaxis JO40_00935 ENOG4105DXN mazG family JO40_00960 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) JO40_00985 ENOG4105BZ1 (ABC) transporter JO40_00990 ENOG4105C26 Dehydrogenase JO40_00995 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) JO40_01030 ENOG4105KRQ Addiction module toxin, Txe YoeB family JO40_01040 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) JO40_01060 ENOG4105E0A ABC, transporter JO40_01065 ENOG4105EHG Permease protein JO40_01070 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) JO40_01080 ENOG4105DJI Methylaspartate mutase, E subunit JO40_01085 ENOG4105CD3 dihydroorotase JO40_01095 ENOG4105C1J atp-dependent rna helicase JO40_01100 ENOG4105SKN orotidine 5''-phosphate decarboxylase JO40_01120 ENOG4105DA5 (ABC) transporter JO40_01130 ENOG4106NKH JO40_01135 ENOG4106J2Q Uncharacterised protein family (UPF0164) JO40_01140 ENOG4105DF5 DNA topoisomerase IV, subunit A JO40_01155 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family JO40_01160 ENOG4105EZ5 reductase JO40_01165 ENOG4105WPN DNA integration recombination invertion protein JO40_01175 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) JO40_01190 ENOG4108UT2 hemolysin iii JO40_01200 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) JO40_01220 ENOG4105D29 Helix-turn-helix type 11 domain protein JO40_01250 ENOG4107QKZ Ompa motb domain protein JO40_01255 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) JO40_01260 ENOG4105CGH 5'-nucleotidase JO40_01310 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) JO40_01315 ENOG4105D9U N-acetyltransferase JO40_01320 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B JO40_01340 ENOG4108I0C methyltransferase JO40_01380 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) JO40_01385 ENOG410841Q phosphoesterase PA-phosphatase related protein JO40_01395 ENOG41062Z1 JO40_01410 ENOG4108IQE Amp-dependent synthetase and ligase JO40_01430 ENOG4105DR5 peptidase JO40_01435 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) JO40_01445 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JO40_01450 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) JO40_01455 ENOG4105C5B carbamate kinase JO40_01460 ENOG4107QI1 Mate efflux family protein JO40_01470 ENOG41084YP 30S ribosomal protein S21 JO40_01485 ENOG4105DFM M18 family aminopeptidase JO40_01490 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) JO40_01495 ENOG4105C4R Atp-dependent dna helicase JO40_01515 ENOG4108JUA Transcriptional regulator JO40_01560 ENOG41061XC JO40_01565 ENOG4108UN4 phage SPO1 DNA polymerase-related protein JO40_01570 ENOG4105C25 Primosomal protein n' JO40_01575 ENOG4105DTN riboflavin biosynthesis protein ribF JO40_01580 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) JO40_01585 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) JO40_01590 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) JO40_01605 ENOG4105EI2 Pseudouridine synthase JO40_01610 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) JO40_01640 ENOG4105BZ1 (ABC) transporter JO40_01655 ENOG4105D98 threonine synthase JO40_01660 ENOG4108VJ1 Transcriptional regulator (CarD family JO40_01665 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) JO40_01670 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) JO40_01695 ENOG41080VC Galactokinase (EC 2.7.1.6) JO40_01700 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) JO40_01705 ENOG4105C0H protease JO40_01715 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO40_01735 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) JO40_01750 ENOG4108I5C dEAD DEAH box helicase JO40_01765 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) JO40_01795 ENOG4105DFA alanine racemase domain protein JO40_01860 ENOG4108JJB ABC transporter JO40_01865 ENOG4105D82 Glutamate dehydrogenase JO40_01885 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase JO40_01895 ENOG41084P6 50S ribosomal protein l28 JO40_01905 ENOG4108JQ7 (ABC) transporter JO40_01925 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JO40_01935 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) JO40_01940 ENOG4105DGN Electron transport complex JO40_01945 ENOG4105DZB Electron transport complex JO40_01955 ENOG4105D6A Electron transport complex JO40_01960 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) JO40_01970 ENOG4105YQK von Willebrand factor type A domain JO40_01975 ENOG41073RW Cytoplasmic filament protein A JO40_01980 ENOG4108SXE JO40_01985 ENOG4107QJD pyruvate phosphate dikinase JO40_01995 ENOG4105HCZ JO40_02010 ENOG4105C8Q Methyl-accepting chemotaxis JO40_02020 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) JO40_02025 ENOG4108UJD 30S ribosomal protein S9 JO40_02030 ENOG410691R Modulates RecA activity (By similarity) JO40_02035 ENOG4108WQH regulatoR JO40_02065 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) JO40_02110 ENOG4106TEA JO40_02115 ENOG4108JYZ YitT family JO40_02135 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) JO40_02140 ENOG41081F0 Precorrin-8x methylmutase JO40_02145 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) JO40_02165 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 JO40_02185 ENOG4106DC9 JO40_02190 ENOG4108ZT0 50S ribosomal protein l17 JO40_02195 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO40_02200 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) JO40_02205 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits JO40_02210 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) JO40_02215 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) JO40_02220 ENOG41084HK 50S ribosomal protein L30 JO40_02225 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) JO40_02230 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) JO40_02235 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) JO40_02240 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) JO40_02245 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits JO40_02250 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) JO40_02255 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) JO40_02260 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal JO40_02265 ENOG41086S0 50s ribosomal protein l29 JO40_02270 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) JO40_02275 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) JO40_02280 ENOG41082G4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) JO40_02285 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) JO40_02290 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity JO40_02295 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) JO40_02300 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) JO40_02305 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) JO40_02310 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) JO40_02315 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) JO40_02340 ENOG4105CB5 ATP-dependent DNA helicase recG JO40_02365 ENOG4105DZW Dipeptidase JO40_02370 ENOG4105C8Q Methyl-accepting chemotaxis JO40_02375 ENOG4105C6E dna polymerase iii JO40_02390 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) JO40_02395 ENOG4107QP8 phosphohexose isomerase JO40_02400 ENOG4105DFM M18 family aminopeptidase JO40_02405 ENOG4107YZP Rhodanese domain protein JO40_02410 ENOG41062BZ domain protein JO40_02465 ENOG4105C3K feS assembly ATPase SufC JO40_02470 ENOG4105DIW FeS assembly protein SUFB JO40_02480 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for JO40_02500 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) JO40_02505 ENOG4105BZU Histidine kinase JO40_02520 ENOG4108IUZ ABC transporter JO40_02525 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) JO40_02535 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) JO40_02540 ENOG4105C8Q Methyl-accepting chemotaxis JO40_02545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JO40_02550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO40_02560 ENOG4108JQ7 (ABC) transporter JO40_02570 ENOG4108VXD carboxy-peptidase JO40_02590 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO40_02595 ENOG4105CFG Acts as a chaperone (By similarity) JO40_02600 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ JO40_02630 ENOG4105E0A ABC, transporter JO40_02635 ENOG4108JTQ reductase JO40_02640 ENOG4105E4R Precorrin-3B C17-methyltransferase JO40_02660 ENOG4105UQX Mate efflux family protein JO40_02665 ENOG4105VVB JO40_02670 ENOG4105C8Q Methyl-accepting chemotaxis JO40_02675 ENOG4108P62 biosynthesis protein (CbiG) JO40_02680 ENOG4105CIA precorrin-4 C(11)-methyltransferase JO40_02685 ENOG4107QJE Chromosome Partitioning Protein JO40_02710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) JO40_02715 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase JO40_02730 ENOG4105CHR reductase JO40_02745 ENOG4105RKW reductase (By JO40_02755 ENOG4105CB5 ATP-dependent DNA helicase recG JO40_02770 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein JO40_02775 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase JO40_02780 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) JO40_02785 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) JO40_02790 ENOG4105C84 Histidine ammonia-lyase JO40_02810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JO40_02850 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JO40_02855 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) JO40_02860 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JO40_02960 ENOG4108YI3 3-hydroxyacyl-CoA-acyl carrier protein transferase JO40_03010 ENOG4105C19 ABC transporter JO40_03155 ENOG4108KSB HipA-like N-terminal domain JO40_03190 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF JO40_03210 ENOG4105BZ1 (ABC) transporter JO40_03280 ENOG4105BZ1 (ABC) transporter JO40_03285 ENOG4105BZ1 (ABC) transporter JO40_03290 ENOG4108IJ2 phosphate acetyltransferase JO40_03295 ENOG4107GWN repeat protein JO40_03300 ENOG4105C0B DNA polymerase III (alpha subunit) JO40_03310 ENOG41090KZ JO40_03325 ENOG4105DPN Oligoendopeptidase f JO40_03345 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) JO40_03380 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO40_03390 ENOG4105DF9 Lipoate-protein, ligase JO40_03400 ENOG4105DVE abc transporter atp-binding protein JO40_03405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family JO40_03410 ENOG4108JJB ABC transporter JO40_03440 ENOG4107PPM cobalt chelatase JO40_03445 ENOG4105DVK Precorrin-2 c20-methyltransferase JO40_03450 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) JO40_03455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) JO40_03465 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) JO40_03470 ENOG4108UKJ Cdp-alcohol phosphatidyltransferase JO40_03475 ENOG4105ESV Glycosyl transferase, family 4 JO40_03505 ENOG4107QID Threonine synthase JO40_03525 ENOG4106VWR JO40_03550 ENOG4105MA4 psp1 domain protein JO40_03555 ENOG4105XVJ Protein of unknown function (DUF327) JO40_03565 ENOG4105DR5 peptidase JO40_03570 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) JO40_03580 ENOG4105CG3 alpha amylase, catalytic region JO40_03590 ENOG4105K95 (LipO)protein JO40_03595 ENOG4105C2J ABC transporter JO40_03625 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein JO40_03635 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO40_03650 ENOG41071ED JO40_03655 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) JO40_03705 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) JO40_03725 ENOG4107R3N Filamentation induced by cAMP protein fic JO40_03740 ENOG4108JJB ABC transporter JO40_03745 ENOG4105BZ1 (ABC) transporter JO40_03785 ENOG4105BZ1 (ABC) transporter JO40_03800 ENOG4105K78 MarR family Transcriptional regulator JO40_03810 ENOG4105C0F tryptophanase EC 4.1.99.1 JO40_03815 ENOG4105D7B Flagellar biosynthesis protein flha JO40_03825 ENOG4105D19 Role in flagellar biosynthesis (By similarity) JO40_03830 ENOG4105VS8 Flagellar biosynthetic protein fliq JO40_03860 ENOG4105CI2 imidazolone-5-propionate hydrolase JO40_03900 ENOG4108T5G Adenylate JO40_03905 ENOG4105DUM transcriptional regulator, lysR family JO40_03915 ENOG4105DEF Extracellular solute-binding protein, family 5 JO40_03920 ENOG4108JQ7 (ABC) transporter JO40_03925 ENOG4105C3U ABC transporter JO40_03930 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO40_03950 ENOG4107QRP cobalamin biosynthesis protein CobW JO40_03955 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase JO40_03970 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase JO40_03985 ENOG4105C4Y ABC transporter JO40_03990 ENOG4105CCS Glutamate formiminotransferase JO40_03995 ENOG4105DP9 ABC transporter JO40_04005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO40_04015 ENOG4105CH2 amidohydrolase JO40_04020 ENOG4105BZU Histidine kinase JO40_04025 ENOG4105WH1 Two component transcriptional regulator luxr family JO40_04030 ENOG4105EYW Ion transport protein JO40_04115 ENOG41081XE plasmid maintenance system antidote protein, xre family JO40_04120 ENOG41080ET plasmid maintenance system killer protein JO40_04130 ENOG4105CJR Integral membrane protein (MviN JO40_04135 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JO40_04140 ENOG4105WYW fructose-bisphosphate aldolase JO40_04170 ENOG4105C3G gtp-binding protein JO40_04175 ENOG4105D07 Signal peptide peptidase, SppA JO40_04180 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) JO40_04200 ENOG4108Q52 Methyltransferase cognate corrinoid protein JO40_04205 ENOG4105C5T Phosphoribosyl pyrophosphate synthase JO40_04210 ENOG4105BZ1 (ABC) transporter JO40_04215 ENOG4105BZ1 (ABC) transporter JO40_04220 ENOG4105C8Q Methyl-accepting chemotaxis JO40_04225 ENOG4105C5X domain protein JO40_04230 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) JO40_04240 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JO40_04260 ENOG4105D6U Sodium Glutamate Symporter JO40_04265 ENOG4105C8Q Methyl-accepting chemotaxis JO40_04270 ENOG4105C8Q Methyl-accepting chemotaxis JO40_04275 ENOG4105D3A purine nucleoside phosphorylase DeoD-type JO40_04325 ENOG4105BZU Histidine kinase JO40_04330 ENOG4105CXT aspartate transcarbamylase JO40_04370 ENOG4105EG2 ABC transporter, permease JO40_04375 ENOG4105D56 permease protein JO40_04385 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) JO40_04395 ENOG4107RFY SbcCD D subunit JO40_04400 ENOG4105C8Q Methyl-accepting chemotaxis JO40_04410 ENOG4105CZV ABC transporter JO40_04430 ENOG4108Z29 Flavodoxin JO40_04445 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) JO40_04450 ENOG4108UVJ appr-1-p processing domain protein JO40_04455 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) JO40_04460 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) JO40_04530 ENOG4106C4Y Protein of unknown function (DUF721) JO40_04575 ENOG4105G3C Type iv pilus assembly JO40_04590 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component JO40_04595 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase JO40_04600 ENOG4107R3E Citrate transporter JO40_04610 ENOG4105C0D helicase JO40_04625 ENOG4105T73 JO40_04640 ENOG4105MZU cell filamentation protein JO40_04650 ENOG4105EJ9 Membrane JO40_04655 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) JO40_04670 ENOG4105ECW sulfate abc transporter JO40_04675 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO40_04680 ENOG4105C8Q Methyl-accepting chemotaxis JO40_04695 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) JO40_04705 ENOG4105DAP Nicotinate phosphoribosyltransferase JO40_04725 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO40_04730 ENOG4105D6S protein involved in catabolism of external DNA JO40_04740 ENOG4107ZYR domain protein JO40_04745 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JO40_04765 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) JO40_04775 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) JO40_04785 ENOG4105CEU Arginine dihydrolase JO40_04790 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) JO40_04805 ENOG4105CZN Potassium uptake protein JO40_04810 ENOG4107ZYR domain protein JO40_04815 ENOG4106S4G JO40_04820 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A JO40_04825 ENOG4105XMH SpoVT AbrB domain protein JO40_04835 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JO40_04840 ENOG4108JU6 CBS domain protein JO40_04845 ENOG4108JU6 CBS domain protein JO40_04860 ENOG4105C9U ATP-dependent DNA helicase RecQ JO40_04875 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) JO40_04890 ENOG4105BZ1 (ABC) transporter JO40_04915 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) JO40_04945 ENOG4105CPK Glycosyl transferase (Group 1 JO40_04950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO40_04955 ENOG4107RCV ABC transporter, permease JO40_04960 ENOG4106TD9 Diguanylate cyclase JO40_04975 ENOG4107QWW Cell wall formation (By similarity) JO40_04980 ENOG4105C8N cysteinyl-tRNA synthetase JO40_04995 ENOG4108KS2 transglutaminase domain protein JO40_05000 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) JO40_05005 ENOG4105C1A potassium transporter peripheral membrane JO40_05010 ENOG4109031 JO40_05060 ENOG4105EIB trna rrna methyltransferase JO40_05095 ENOG4108JUA Transcriptional regulator JO40_05115 ENOG4105DJV ribulose-phosphate 3-epimerase JO40_05125 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) JO40_05135 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane JO40_05145 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) JO40_05155 ENOG4108IUW ABC transporter JO40_05170 ENOG4105C8Q Methyl-accepting chemotaxis JO40_05215 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) JO40_05235 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) JO40_05240 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) JO40_05260 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 JO40_05270 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein JO40_05285 ENOG4105C3J Cysteine desulfurase JO40_05290 ENOG4105D49 3-dehydroquinate synthase JO40_05295 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) JO40_05320 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) JO40_05335 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) JO40_05345 ENOG4105BZW Glycerate kinase JO40_05350 ENOG4105C59 p-type ATPase JO40_05360 ENOG4108YZ4 nudix hydrolase JO40_05370 ENOG4108RMU ferritin dps family protein JO40_05375 ENOG4105D3R alkyl hydroperoxide reductase JO40_05380 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) JO40_05395 ENOG4105D1H recombination factor protein RarA JO40_05400 ENOG4105DER m42 family JO40_05415 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) JO40_05435 ENOG4105D17 glycoside hydrolase, family 3 domain protein JO40_05440 ENOG41062VP JO40_05545 ENOG4108JJB ABC transporter JO40_05560 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) JO40_05600 ENOG4105PAD Hydrolase JO40_05695 ENOG4108JJB ABC transporter JO40_05750 ENOG4105BZU Histidine kinase JO40_05760 ENOG4105Y6R JO40_05765 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) JO40_05800 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO40_05815 ENOG4105FZW flagellar biosynthesis regulator FlhF JO40_05820 ENOG4105CIH Imidazole acetol-phosphate transaminase JO40_05855 ENOG410822I Flagellar hook capping protein JO40_05860 ENOG4105BZE flagellar hook protein, FlgE JO40_05870 ENOG4107R0U MotA TolQ exbB proton channel JO40_05875 ENOG4107XSU flagellar motor protein motb JO40_05880 ENOG41064SM flagellar basal body-associated protein flil JO40_05885 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO40_05890 ENOG4105DD5 Flagellar motor switch protein JO40_05900 ENOG4105CN7 Flagellar biosynthetic protein FliP JO40_05945 ENOG4107QWB Ornithine cyclodeaminase JO40_05950 ENOG4105E4C Lytic transglycosylase catalytic JO40_05955 ENOG41063VX Inherit from COG: glutaredoxin-related protein JO40_05970 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) JO40_05985 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) JO40_05990 ENOG4105F8V Hydrolase, tatD family JO40_06000 ENOG4105BZU Histidine kinase JO40_06005 ENOG4105BZU Histidine kinase JO40_06010 ENOG4105CB5 ATP-dependent DNA helicase recG JO40_06025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JO40_06030 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) JO40_06035 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) JO40_06080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO40_06085 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) JO40_06105 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) JO40_06150 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase JO40_06215 ENOG4105C26 Dehydrogenase JO40_06225 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family JO40_06235 ENOG4105EZ5 reductase JO40_06240 ENOG41061GT Aldolase JO40_06245 ENOG4105E2A Dehydrogenase JO40_06250 ENOG4105C85 amino acid JO40_06260 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) JO40_06265 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) JO40_06280 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO40_06285 ENOG4105CFP Peptidase U32 JO40_06295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO40_06300 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein JO40_06305 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JO40_06310 ENOG4105IJJ transcriptional regulator, crp fnr family JO40_06325 ENOG4105CTQ phosphohexokinase JO40_06355 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) JO40_06360 ENOG41068UM RNA Polymerase JO40_06370 ENOG4105ERG peptidase m48, ste24p JO40_06375 ENOG4108T5G Adenylate JO40_06485 ENOG4108RAC Rubrerythrin JO40_06490 ENOG4105C9U ATP-dependent DNA helicase RecQ JO40_06495 ENOG410826D Involved in DNA repair and RecF pathway recombination (By similarity) JO40_06505 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) JO40_06560 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) JO40_06570 ENOG4108IUW ABC transporter JO40_06585 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JO40_06590 ENOG4105CJW magnesium transporter JO40_06600 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) JO40_06610 ENOG41080XV Thioredoxin JO40_06615 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination JO40_06620 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination JO40_06630 ENOG4105EHG Permease protein JO40_06645 ENOG4105EET magnesium chelatase JO40_06650 ENOG4105EET magnesium chelatase JO40_06675 ENOG4105DZR Type I site-specific deoxyribonuclease JO40_06685 ENOG4105DFD Na H antiporter JO40_06690 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase JO40_06695 ENOG4105VEM Conserved domain protein JO40_06700 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JO40_06710 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) JO40_06735 ENOG4105FAV ABC, transporter JO40_06740 ENOG4105FDK ABC transporter JO40_06750 ENOG4108JJ9 ABC, transporter JO40_06755 ENOG4105BZ1 (ABC) transporter JO40_06765 ENOG4106N2C JO40_06785 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) JO40_06790 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) JO40_06795 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) JO40_06800 ENOG4105VB6 UPF0109 protein JO40_06805 ENOG4105K5M 30s ribosomal protein S16 JO40_06810 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) JO40_06825 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO40_06830 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO40_06835 ENOG4105FE9 pseudouridine synthase JO40_06845 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) JO40_06850 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) JO40_06900 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) JO40_06905 ENOG4105KT7 mgtC SapB transporter JO40_06930 ENOG4107QJQ Mate efflux family protein JO40_06935 ENOG4108T5G Adenylate JO40_06940 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) JO40_06965 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) JO40_06970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO40_06975 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) JO40_06980 ENOG4105MBR gumn family JO40_06990 ENOG4107TT5 NLP P60 protein JO40_06995 ENOG4105CEY Amp-dependent synthetase and ligase JO40_07005 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO40_07045 ENOG4108F3G Type I restriction-modification system, R subunit JO40_07050 ENOG4105CVR type I restriction-modification system JO40_07060 ENOG4107QTH restriction modification system DNA specificity domain JO40_07070 ENOG4107QTH restriction modification system DNA specificity domain JO40_07085 ENOG4107QW4 alcohol dehydrogenase JO40_07120 ENOG4105JAB phenazine biosynthesis protein, phzf family JO40_07135 ENOG4105DUM transcriptional regulator, lysR family JO40_07190 ENOG41067QW Transcriptional regulator JO40_07195 ENOG4107QMH DNA methylase JO40_07200 ENOG4107J0C type IIi JO40_07205 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein JO40_07220 ENOG4108YZG isomerase JO40_07225 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) JO40_07230 ENOG4105C3S Mate efflux family protein JO40_07240 ENOG4107Z3H Transcriptional regulator, TetR family JO40_07255 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) JO40_07275 ENOG4105CJ2 (LipO)protein JO40_07280 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) JO40_07285 ENOG4105IJJ transcriptional regulator, crp fnr family JO40_07300 ENOG4107SCN K03215 23S rRNA (uracil1939-C5)-methyltransferase EC 2.1.1.190 JO40_07320 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JO40_07325 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JO40_07330 ENOG4105VIE preprotein translocase, subunit YajC JO40_07340 ENOG4108SP1 single-stranded DNA-binding protein JO40_07350 ENOG4105C8V SAICAR synthetase JO40_07355 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) JO40_07365 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) JO40_07370 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) JO40_07380 ENOG4105DWF phosphomethylpyrimidine kinase JO40_07390 ENOG4105CJ1 ABC, transporter JO40_07420 ENOG4105CGP Urocanate hydratase JO40_07435 ENOG4105CVJ phosphoglycerate mutase JO40_07440 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) JO40_07450 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) JO40_07470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO40_07475 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) JO40_07495 ENOG4108HU6 Metal dependent phosphohydrolase JO40_07500 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) JO40_07510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) JO40_07515 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) JO40_07530 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) JO40_07535 ENOG4105C8Q Methyl-accepting chemotaxis JO40_07585 ENOG4105BZ1 (ABC) transporter JO40_07595 ENOG4105CFP Peptidase U32 JO40_07600 ENOG4106N3A copper homeostasis protein cutc JO40_07660 ENOG4105EHZ conserved protein UCP016719 JO40_07680 ENOG4105CT1 (ABC) transporter JO40_07685 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase JO40_07695 ENOG4105SCY DNAK suppressor JO40_07700 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) JO40_07705 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO40_07710 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) JO40_07715 ENOG4105CVS RNA methyltransferase TrmH family, group 1 JO40_07730 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) JO40_07735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family JO40_07740 ENOG4105W0I repeat-containing protein JO40_07755 ENOG4105BZU Histidine kinase JO40_07760 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs JO40_07770 ENOG4105ZFX JO40_07785 ENOG4105KME endoribonuclease L-psp JO40_07815 ENOG4105CJ1 ABC, transporter JO40_07835 ENOG4105BZU Histidine kinase JO40_07840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JO40_07865 ENOG4108UB4 uncharacterized protein ygjQ JO40_07875 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) JO40_07890 ENOG4105D48 metallophosphoesterase JO40_07900 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) JO40_07910 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO40_07920 ENOG41085BT Protein of unknown function (DUF1312) JO40_07925 ENOG4105D78 K07001 NTE family protein JO40_07930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase JO40_07935 ENOG4105HA9 of methanol dehydrogenase type JO40_07940 ENOG4108V0P LemA family JO40_07945 ENOG4105C75 arginyL-tRNA synthetase JO40_07950 ENOG4105MJ2 Competence protein JO40_07955 ENOG4105W5Q DNA repair protein (RadC JO40_07960 ENOG4105DZ1 carboxypeptidase JO40_07975 ENOG4105TMB Formate nitrite transporter JO40_07980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase JO40_07985 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) JO40_07995 ENOG4105I03 Flagellin JO40_08000 ENOG4105CGA flagellar basal-body rod protein FlgG JO40_08005 ENOG4105CGA flagellar basal-body rod protein FlgG JO40_08010 ENOG410680E Flagellar protein JO40_08015 ENOG4105E0Y RtcB Protein JO40_08090 ENOG4105BZ1 (ABC) transporter JO40_08095 ENOG4105BZ1 (ABC) transporter JO40_08115 ENOG4108IG5 Transcriptional regulator JO40_08130 ENOG4108JJB ABC transporter JO40_08165 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) JO40_08180 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) JO40_08200 ENOG4108W50 ppic-type peptidyL-prolyl cis-trans isomerase JO40_08205 ENOG4106SUR Protein of unknown function DUF115 JO40_08235 ENOG4105CIN aminoacyl-histidine dipeptidase JO40_08245 ENOG4105DSE periplasmic solute binding protein JO40_08260 ENOG4106KG8 JO40_08265 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) JO40_08270 ENOG4105C3F Signal peptidase i JO40_08280 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator JO40_08305 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) JO40_08310 ENOG41082BE ankyrin repeat-containing protein JO40_08315 ENOG4105NBF ammecr1 domain protein JO40_08330 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) JO40_08335 ENOG4105C6K Malic enzyme JO40_08360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO40_08370 ENOG4108JQ7 (ABC) transporter JO40_08385 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN JO40_08390 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) JO40_08405 ENOG4105C34 Pseudouridine synthase JO40_08420 ENOG4105DSJ YicC domain protein JO40_08425 ENOG4108Z4J Cytidine monophosphate kinase JO40_08430 ENOG4106UUF JO40_08440 ENOG4105C22 threonyL-tRNA synthetase JO40_08470 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) JO40_08495 ENOG4107ZET Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) JO40_08505 ENOG41089XN JO40_08515 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase JO40_08520 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase JO40_08525 ENOG4107ZT5 Thiol disulfide interchange protein JO40_08555 ENOG4105C32 Amino acid ABC transporter (Permease) JO40_08560 ENOG4105CF8 branched-chain amino acid ABC transporter, permease JO40_08565 ENOG4105C0Z ABC transporter JO40_08570 ENOG4108IV0 ABC, transporter JO40_08585 ENOG4105CMT Dihydroxyacetone kinase JO40_08590 ENOG4105CMT Dihydroxyacetone kinase JO40_08600 ENOG4108U1V ABC transporter, permease JO40_08625 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) JO40_08630 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) JO40_08635 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) JO40_08640 ENOG4105CHV Transcription elongation factor NusA JO40_08645 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) JO40_08665 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) JO40_08670 ENOG4105C0F tryptophanase EC 4.1.99.1 JO40_08690 ENOG4105WN5 stage II sporulation protein JO40_08720 ENOG41090Q2 JO40_08730 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) JO40_08735 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase JO40_08755 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) JO40_08770 ENOG4105DR4 Methyltransferase JO40_08775 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) JO40_08780 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) JO40_08795 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) JO40_08800 ENOG4105CEM UPF0597 protein JO40_08805 ENOG4108JQB penicillin-binding protein 1C JO40_08810 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) JO40_08815 ENOG41084MZ 50S ribosomal protein L35 JO40_08820 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) JO40_08825 ENOG4106BH8 JO40_08830 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) JO40_08835 ENOG41082MQ UPF0178 protein JO40_08845 ENOG4105E9H Lytic Murein transglycosylase JO40_08935 ENOG4105C87 Aminotransferase class I and II JO40_08960 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase JO40_08995 ENOG4105C5X domain protein JO40_09010 ENOG4105C94 Transporter JO40_09020 ENOG4105BZG amino acid carrier protein JO40_09030 ENOG41063XV JO40_09035 ENOG4105CPI Metal Dependent Phosphohydrolase JO40_09040 ENOG4105C98 muts2 protein JO40_09085 ENOG4105C37 (CBS) domain JO40_09090 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) JO40_09100 ENOG4105C9A Phoh family JO40_09115 ENOG4105CP7 Triose-phosphate isomerase JO40_09120 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) JO40_09140 ENOG4105C5X domain protein JO40_09155 ENOG4108IJ0 Aspartate ammonia-lyase JO40_09160 ENOG4108ZG0 Ompa motb domain protein JO40_09170 ENOG4105DVT helicase JO40_09190 ENOG4105MB2 JO40_09195 ENOG4106AG2 JO40_09205 ENOG4105J3I JO40_09245 ENOG4107JR8 Colicin v production protein JO40_09250 ENOG4105FA2 dna polymerase iii JO40_09260 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family JO40_09265 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) JO40_09275 ENOG4105C0H protease JO40_09280 ENOG4107RWR Sodium hydrogen exchanger JO40_09330 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 JO40_09340 ENOG4107ZBH radical SAM domain protein JO40_09350 ENOG4105KVH Transcriptional regulator JO40_09365 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) JO40_09370 ENOG4105D29 Helix-turn-helix type 11 domain protein JO40_09385 ENOG4108IUW ABC transporter JO40_09395 ENOG4108R6W Transcriptional regulator, ARAC family JO40_09400 ENOG4105BZ1 (ABC) transporter JO40_09425 ENOG4108JJB ABC transporter JO40_09475 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) JO40_09480 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) JO40_09510 ENOG4105KRQ Addiction module toxin, Txe YoeB family JO40_09515 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) JO40_09550 ENOG4108RY1 ATP synthase, subunit E JO40_09560 ENOG4105C59 p-type ATPase JO40_09570 ENOG4105EI2 Pseudouridine synthase JO40_09585 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) JO40_09635 ENOG4107QMG Nad synthetase JO40_09650 ENOG4105C5H ABC transporter JO40_09655 ENOG4105I76 (LipO)protein JO40_09660 ENOG4108DGI Phosphoribosylformylglycinamidine synthase I JO40_09670 ENOG4105DCI Phosphohydrolase JO40_09690 ENOG4106FRC JO40_09695 ENOG4107W2M Sodium hydrogen exchanger JO40_09720 ENOG4105DTI Phosphonopyruvate decarboxylase JO40_09725 ENOG4107STF Involved in phosphonate degradation (By similarity) JO40_09765 ENOG4107SWE Methyltransferase JO40_09780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase JO40_09785 ENOG4107S6X Glycosyl transferase, family 2 JO40_09795 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase JO40_09800 ENOG4105FAW cDP-glucose 4,6-dehydratase JO40_09815 ENOG4108SMP Nad-dependent epimerase dehydratase JO40_09830 ENOG4105K64 Glycosyl transferase, family 2 JO40_09895 ENOG4105W1T Glycosyl Transferase JO40_09920 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JO40_09950 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JO40_09960 ENOG4107QPH glycogen) synthase JO40_09965 ENOG4105DMT epimerase dehydratase JO40_09970 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) JO40_09975 ENOG4105C1B dTDP-glucose 4-6-dehydratase JO40_09980 ENOG4105CUT histidyl-tRNA synthetase JO40_09990 ENOG4105CY0 Metallo-Beta-Lactamase JO40_09995 ENOG4106SWD JO40_10005 ENOG4105C5H ABC transporter JO40_10015 ENOG4105CN1 protease JO40_10075 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) JO40_10080 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) JO40_10155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO40_10160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO40_10195 ENOG4105VXP Protein of unknown function DUF86 JO40_10275 ENOG410667J hydrolase JO40_10310 ENOG4105VXP Protein of unknown function DUF86 JO40_10330 ENOG4105MZG transcriptional modulator of maze toxin, mazf JO40_10350 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) JO40_10355 ENOG4108R3D Electron transport complex JO40_10360 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) JO40_10415 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JO40_10430 ENOG4106YRG JO40_10445 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) JO40_10455 ENOG4105K46 50S ribosomal protein l27 JO40_10460 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control JO40_10465 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) JO40_10475 ENOG4107ZFZ Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) JO40_10480 ENOG4105CAH Chromate JO40_10490 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO40_10500 ENOG4105CGK Exodeoxyribonuclease III JO40_10510 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding JO40_10520 ENOG4105DR5 peptidase JO40_10530 ENOG4108JQC penicillin-binding protein 1A JO40_10585 ENOG4105DJ0 Poly(A) Polymerase JO40_10590 ENOG41090QR JO40_10615 ENOG4105K56 Transcriptional regulator JO40_10620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JO40_10635 ENOG4105BZA Phosphoglycerate kinase JO40_10640 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase JO40_10650 ENOG4107NGC Flagellar filament outer layer protein JO40_10660 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) JO40_10680 ENOG4105CEV competence damage-inducible protein JO40_10710 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) JO40_10740 ENOG4105CJ1 ABC, transporter JO40_10750 ENOG4108QUE repeat-containing protein JO40_10755 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase JO40_10760 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) JO40_10765 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) JO40_10770 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit JO40_10775 ENOG4108WBK V-type ATP synthase subunit D JO40_10780 ENOG4107U1W v-type ATP synthase subunit I JO40_10790 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) JO40_10795 ENOG4105Z8H single-stranded DNA-binding protein JO40_10800 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) JO40_10805 ENOG4105K9Q Binds to the 23S rRNA (By similarity) JO40_10815 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) JO40_10820 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JO40_10825 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation JO40_10845 ENOG4105C87 Aminotransferase class I and II JO40_10855 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) JO40_10870 ENOG4107QKZ Ompa motb domain protein JO40_10875 ENOG4105CDU Replicative dna helicase JO40_10885 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) JO40_10890 ENOG4107Z25 Basic membrane protein JO40_10895 ENOG4105M7K Involved in the transcription termination process (By similarity) JO40_10900 ENOG4106JWJ JO40_10910 ENOG4105CQ7 ATP-dependent helicase JO40_10925 ENOG4105CV1 Transketolase (EC 2.2.1.1) JO40_10930 ENOG4105CMR udp-glucose 4-epimerase JO40_10935 ENOG4105MAX Superoxide reductase JO40_10985 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) JO40_11015 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) JO40_11020 ENOG4105KZ7 phosphocarrier protein hpr JO40_11045 ENOG4105D48 metallophosphoesterase JO40_11055 ENOG4105EAH synthase JO40_11080 ENOG4105QTX Pfam:UPF0153 JO40_11095 ENOG4105HHA aminodeoxychorismate lyase JO40_11115 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JO40_11120 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) JO40_11125 ENOG4107S2N Type III effector Hrp-dependent JO40_11130 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) JO40_11135 ENOG4105VP7 SAF domain protein JO40_11145 ENOG4105E98 transcriptional regulator DeoR family JO40_11150 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO40_11175 ENOG4108YZY peptidylprolyl cis-trans isomerase JO40_11185 ENOG4106XJW JO40_11190 ENOG4108ZVA radical SAM domain protein JO40_11205 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) JO40_11210 ENOG4107QW4 alcohol dehydrogenase JO40_11215 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) JO40_11225 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family JO40_11230 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JO40_11235 ENOG4108V3E phosphoribosylglycinamide formyltransferase JO40_11240 ENOG4105DC1 bifunctional purine biosynthesis protein purh JO40_11245 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) JO40_11250 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) JO40_11255 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) JO40_11265 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JO40_11275 ENOG4106W1H JO40_11300 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) JO40_11325 ENOG4105C9M aspartyl-trna synthetase JO40_11335 ENOG4105YFD chemotaxis, protein JO40_11345 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) JO40_11350 ENOG4105C5H ABC transporter JO40_11355 ENOG4107QHI -hydrogenase JO40_11360 ENOG4105BZ8 glutamate synthase JO40_11365 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) JO40_11405 ENOG4107V28 uracil phosphoribosyltransferase JO40_11425 ENOG4105C5I Dehydrogenase JO40_11435 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor JO40_11445 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) JO40_11450 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) JO40_11465 ENOG4107QMH DNA methylase JO40_11480 ENOG4105CHY citrate lyase, alpha JO40_11490 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) JO40_11500 ENOG4105C2M dna polymerase I JO40_11505 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) JO40_11515 ENOG4105E2X shikimate dehydrogenase JO40_11520 ENOG4105E66 phosphoriboisomerase A JO40_11525 ENOG4106S0F JO40_11530 ENOG4108120 Pasta domain protein JO40_11535 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) JO40_11540 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) JO40_11550 ENOG4108JJB ABC transporter JO40_11555 ENOG4105VKD bioY protein JO40_11665 ENOG4105YGP holo-ACP synthase CitX JO40_11670 ENOG4105DUA (citrate (pro-3S)-lyase ligase JO40_11675 ENOG4107GFK fumarate JO40_11680 ENOG4106DSS Tartrate dehydratase subunit alpha JO40_11705 ENOG4105C19 ABC transporter JO40_11710 ENOG4107RBB ABC transporter, permease JO40_11730 ENOG4108SDV Periplasmic Protein JO40_11745 ENOG4105BZ1 (ABC) transporter JO40_11750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO40_11765 ENOG4105EJQ L-serine dehydratase JO40_11775 ENOG41082DI 50s ribosomal protein l31 JO40_11780 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) JO40_11800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JO40_11830 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) JO40_11845 ENOG4107Z9R response regulator JO40_11855 ENOG4105YFD chemotaxis, protein JO40_11860 ENOG4105CBS Chea signal transduction histidine kinase JO40_11875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase JO40_11880 ENOG4105CDY transcriptional regulatory protein JO40_11900 ENOG4106XCQ Inherit from COG: Pfam:DUF82 JO40_11915 ENOG41068FD JO40_11925 ENOG4106RHC JO40_11930 ENOG4105I03 Flagellin JO40_11935 ENOG4105I03 Flagellin JO40_11945 ENOG4107VE5 flagellar hook-associated protein JO40_11950 ENOG4106SAP JO40_11960 ENOG4105K8N protein family UPF0079, ATPase JO40_11970 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO40_11975 ENOG4105CSA Coproporphyrinogen iii oxidase JO40_11980 ENOG4105C3F Signal peptidase i JO40_11990 ENOG4106QD2 JO40_12000 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein JO40_12020 ENOG4107RIZ hflk protein JO40_12030 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) JO40_12060 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein JO40_12090 ENOG4105CJN penicillin-binding protein JO40_12100 ENOG4105D7A ATP-binding protein JO40_12120 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) JO40_12130 ENOG410698I JO40_12140 ENOG4105X4X Protein of unknown function DUF115 JO40_12165 ENOG4107RBJ symporter JO40_12185 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) JO40_12190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) JO40_12195 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) JO40_12205 ENOG4105G9E JO40_12210 ENOG4108J59 Extracellular solute-binding protein, family 5 JO40_12230 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) JO40_12235 ENOG4105C7N Xanthine uracil vitamin C permease JO40_12245 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) JO40_12260 ENOG4105CNI cell division protein FtsW JO40_12265 ENOG4105CJN penicillin-binding protein JO40_12280 ENOG4105DFF Rod shape-determining protein mreb JO40_12295 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO40_12300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) JO40_12305 ENOG4105C0P Mg chelatase subunit ChlI JO40_12325 ENOG4108JDX DNA polymerase iii, epsilon subunit JO40_12335 ENOG4105DPN Oligoendopeptidase f JO40_12345 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) JO40_12390 ENOG4105BZ1 (ABC) transporter JO40_12775 ENOG4105F8V Hydrolase, tatD family JO40_12785 ENOG4105K6T rare lipoprotein A JO40_12795 ENOG4105BZF Glycosyl transferase (Group 1 JO40_12800 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) JO40_12805 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JO40_12810 ENOG41066A3 ATP guanido phosphotransferase JO40_12815 ENOG4108Z0C Uvrb UvrC protein JO40_12825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO40_12830 ENOG4105D60 lipoprotein releasing system transmembrane protein JO40_12840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) JO40_12855 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) JO40_12895 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii JO40_12900 ENOG4108UIC UPF0340 protein JO40_12935 ENOG4105C3U ABC transporter JO40_12940 ENOG4108JQ7 (ABC) transporter JO40_12955 ENOG4108HED Type II restriction JO40_12960 ENOG4105C12 Phosphoribosylglycinamide synthetase JO40_12965 ENOG4105CXB phosphoribosylaminoimidazole synthetase JO40_12975 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) JO40_12980 ENOG4106B9X JO40_12985 ENOG4105C0H protease JO40_12990 ENOG41069X2 JO40_13000 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) JO40_13005 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) JO40_13015 ENOG4105K4W Could be involved in septation (By similarity) JO40_13020 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) JO40_13025 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) JO40_13040 ENOG410684W JO40_13125 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) JO40_13160 ENOG4105UIB (ABC) transporter JO40_13165 ENOG4108JQ9 ABC transporter JO40_13170 ENOG4107TFB basic membrane JO40_13175 ENOG4105DER m42 family JO40_13180 ENOG4105CPF Cell wall formation (By similarity) JO40_13190 ENOG4108IUJ 4-alpha-glucanotransferase JO40_13195 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JO40_13200 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) JO40_13210 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) JO40_13220 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein JO40_13225 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JO40_13230 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) JO40_13235 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) JO40_13240 ENOG4105VG0 50S ribosomal protein l34 JO40_13245 ENOG41086CX Inherit from COG: 40-residue yvtn family beta-propeller repeat protein JO40_13250 ENOG4107SIG periplasmic solute binding protein JO40_13255 ENOG4105DIK (ABC) transporter JO40_13260 ENOG4107RPQ ABC transporter JO40_13275 ENOG4105D17 glycoside hydrolase, family 3 domain protein JO40_13290 ENOG4108JIR Flagellum-specific ATP synthase JO40_13295 ENOG4105W2B Flagellar assembly protein JO40_13300 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO40_13305 ENOG4107U2N Flagellar M-ring protein JO40_13310 ENOG41069WH flagellar hook-basal body complex JO40_13315 ENOG4108ZC9 flagellar basal-body rod protein flgc JO40_13320 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) JO40_13325 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) JO40_13330 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) JO40_13335 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JO40_13340 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) JO40_13345 ENOG4105C79 DNA protecting protein DprA JO40_13360 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) JO40_13365 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) JO40_13370 ENOG4108UFP Essential cell division protein (By similarity) JO40_13375 ENOG4105CNI cell division protein FtsW JO40_13395 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) JO40_13400 ENOG4107YM1 mraZ protein