locus-tag	class	description
E4N75_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N75_00060	COG0577	efflux transmembrane transporter activity
E4N75_00060	COG1136	(ABC) transporter
E4N75_00065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N75_00120	COG1266	CAAX protease self-immunity
E4N75_00130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N75_00185	COG1012	belongs to the aldehyde dehydrogenase family
E4N75_00215	COG0531	amino acid
E4N75_00225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_00245	COG0840	transmembrane signaling receptor activity
E4N75_00250	COG0826	peptidase U32
E4N75_00260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_00265	COG1509	lysine 2,3-aminomutase activity
E4N75_00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N75_00275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_00290	COG0205	6-phosphofructokinase activity
E4N75_00340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N75_00360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_00430	COG1652	LysM domain
E4N75_00430	COG2823	Periplasmic or secreted lipoprotein
E4N75_00440	COG1592	Rubrerythrin
E4N75_00445	COG0514	ATP-dependent DNA helicase (RecQ)
E4N75_00450	COG1381	Involved in DNA repair and RecF pathway recombination
E4N75_00460	COG0343	queuine tRNA-ribosyltransferase activity
E4N75_00520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N75_00535	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N75_00545	COG4555	ABC transporter
E4N75_00565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N75_00570	COG2239	Acts as a magnesium transporter
E4N75_00580	COG0546	phosphoglycolate phosphatase activity
E4N75_00590	COG3118	belongs to the thioredoxin family
E4N75_00600	COG1120	ATPase activity
E4N75_00605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_00620	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_00620	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_00625	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_00660	COG1757	Na H antiporter
E4N75_00665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N75_00670	COG4443	Transcriptional Coactivator p15 (PC4)
E4N75_00675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N75_00680	COG0301	tRNA thio-modification
E4N75_00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_00715	COG1121	(ABC) transporter
E4N75_00730	COG1132	(ABC) transporter
E4N75_00760	COG0335	large ribosomal subunit rRNA binding
E4N75_00765	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N75_00775	COG1837	Belongs to the UPF0109 family
E4N75_00780	COG0228	four-way junction DNA binding
E4N75_00805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N75_00810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N75_00815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N75_00825	COG1902	pentaerythritol trinitrate reductase activity
E4N75_00825	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_00855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N75_00860	COG1285	pathogenesis
E4N75_00885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N75_00890	COG0534	Mate efflux family protein
E4N75_00895	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_00900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N75_00905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_00920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N75_00930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_00935	COG0116	Belongs to the methyltransferase superfamily
E4N75_00940	COG3735	TraB family
E4N75_00950	COG0791	NLP P60 protein
E4N75_00955	COG0318	PFAM AMP-dependent synthetase and ligase
E4N75_00980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_01025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N75_01045	COG0732	type I restriction modification DNA specificity domain
E4N75_01050	COG4974	Belongs to the 'phage' integrase family
E4N75_01070	COG1979	alcohol dehydrogenase
E4N75_01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N75_01130	COG3340	Belongs to the peptidase S51 family
E4N75_01135	COG0698	ribose 5-phosphate isomerase
E4N75_01140	COG0039	L-malate dehydrogenase activity
E4N75_01150	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_01150	COG3848	Pyruvate phosphate dikinase
E4N75_01155	COG1309	transcriptional regulator
E4N75_01170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_01190	COG1477	protein flavinylation
E4N75_01195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N75_01200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N75_01235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N75_01240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N75_01250	COG0629	single-stranded DNA binding
E4N75_01260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N75_01265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N75_01280	COG0482	sulfurtransferase activity
E4N75_01300	COG1131	(ABC) transporter
E4N75_01325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N75_01330	COG0406	alpha-ribazole phosphatase activity
E4N75_01335	COG0322	excinuclease ABC activity
E4N75_01345	COG1921	L-seryl-tRNASec selenium transferase activity
E4N75_01365	COG1136	(ABC) transporter
E4N75_01365	COG0577	efflux transmembrane transporter activity
E4N75_01370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N75_01400	COG1639	'signal transduction protein
E4N75_01410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N75_01420	COG0101	tRNA pseudouridine synthase activity
E4N75_01435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N75_01495	COG0657	acetylesterase activity
E4N75_01500	COG0826	peptidase U32
E4N75_01505	COG3142	Participates in the control of copper homeostasis
E4N75_01525	COG0463	Glycosyl transferase, family 2
E4N75_01540	COG3876	Protein conserved in bacteria
E4N75_01545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N75_01565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_01570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N75_01575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N75_01580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N75_01585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N75_01590	COG0484	heat shock protein binding
E4N75_01595	COG0528	UMP kinase activity
E4N75_01600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N75_01620	COG2204	response regulator
E4N75_01625	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N75_01645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N75_01670	COG0251	oxidation-reduction process
E4N75_01695	COG2197	response regulator
E4N75_01700	COG1131	(ABC) transporter
E4N75_01715	COG4585	Histidine kinase
E4N75_01720	COG0542	response to heat
E4N75_01755	COG2949	membrane
E4N75_01765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N75_01780	COG1692	metallophosphoesterase
E4N75_01790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N75_01800	COG0484	heat shock protein binding
E4N75_01805	COG2089	acid synthase
E4N75_01810	COG5341	Protein conserved in bacteria
E4N75_01815	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N75_01820	COG0584	glycerophosphoryl diester phosphodiesterase
E4N75_01825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N75_01830	COG1704	LemA family
E4N75_01835	COG0018	arginyl-trna synthetase
E4N75_01840	COG1040	competence protein
E4N75_01845	COG2003	Belongs to the UPF0758 family
E4N75_01850	COG1686	Belongs to the peptidase S11 family
E4N75_01855	COG0017	Asparaginyl-tRNA synthetase
E4N75_01865	COG2116	formate transmembrane transporter activity
E4N75_01870	COG2084	Dehydrogenase
E4N75_01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N75_01905	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N75_01910	COG1690	Belongs to the RtcB family
E4N75_01980	COG1132	(ABC) transporter
E4N75_01985	COG1132	(ABC) transporter
E4N75_01990	COG1132	(ABC) transporter
E4N75_02025	COG1132	(ABC) transporter
E4N75_02030	COG1129	ABC transporter
E4N75_02050	COG5492	domain, Protein
E4N75_02060	COG2801	Transposase and inactivated derivatives
E4N75_02065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N75_02065	COG0551	DNA topoisomerase type I activity
E4N75_02090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4N75_02115	COG3451	type IV secretory pathway VirB4
E4N75_02140	COG2948	multi-organism process
E4N75_02225	COG2003	Belongs to the UPF0758 family
E4N75_02295	COG2268	Band 7 protein
E4N75_02345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N75_02360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N75_02385	COG2604	Protein of unknown function DUF115
E4N75_02415	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N75_02425	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N75_02445	COG0442	prolyl-tRNA aminoacylation
E4N75_02460	COG1879	ABC-type sugar transport system periplasmic component
E4N75_02485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N75_02490	COG0666	response to abiotic stimulus
E4N75_02495	COG2078	PFAM AMMECR1 domain protein
E4N75_02495	COG3885	ferrous iron binding
E4N75_02510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N75_02515	COG0281	malic enzyme
E4N75_02535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_02540	COG0444	Belongs to the ABC transporter superfamily
E4N75_02545	COG4608	Belongs to the ABC transporter superfamily
E4N75_02555	COG0426	domain, Protein
E4N75_02555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N75_02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_02575	COG0444	Belongs to the ABC transporter superfamily
E4N75_02580	COG4608	Belongs to the ABC transporter superfamily
E4N75_02605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_02610	COG0444	Belongs to the ABC transporter superfamily
E4N75_02615	COG4608	Belongs to the ABC transporter superfamily
E4N75_02635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N75_02640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N75_02655	COG0564	pseudouridine synthase activity
E4N75_02660	COG0285	dihydrofolate synthase activity
E4N75_02670	COG1561	YicC-like family, N-terminal region
E4N75_02675	COG1102	Psort location Cytoplasmic, score
E4N75_02680	COG3706	GGDEF domain
E4N75_02690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N75_02715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N75_02720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N75_02745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N75_02755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N75_02775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N75_02835	COG2376	Dihydroxyacetone kinase
E4N75_02840	COG2376	Dihydroxyacetone kinase
E4N75_02850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_02880	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N75_02885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N75_02900	COG0779	Required for maturation of 30S ribosomal subunits
E4N75_02905	COG0019	diaminopimelate decarboxylase activity
E4N75_02920	COG0563	adenylate kinase activity
E4N75_02925	COG3033	Beta-eliminating lyase
E4N75_02945	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N75_02985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N75_02990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N75_03010	COG0459	protein refolding
E4N75_03030	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N75_03040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N75_03055	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N75_03060	COG3681	Belongs to the UPF0597 family
E4N75_03065	COG4953	penicillin-binding protein 1C
E4N75_03075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N75_03080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N75_03090	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N75_03095	COG1671	Belongs to the UPF0178 family
E4N75_03105	COG0741	lytic transglycosylase activity
E4N75_03105	COG1388	LysM domain
E4N75_03195	COG0058	SHG alpha-glucan phosphorylase activity
E4N75_03205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_03230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N75_03265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_03275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N75_03280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N75_03285	COG4750	Nucleotidyl transferase
E4N75_03290	COG1115	amino acid carrier protein
E4N75_03310	COG1193	negative regulation of DNA recombination
E4N75_03365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N75_03375	COG1702	phosphate starvation-inducible protein PhoH
E4N75_03390	COG0149	triose-phosphate isomerase activity
E4N75_03395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N75_03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_03435	COG2885	chlorophyll binding
E4N75_03445	COG1199	ATP-dependent helicase activity
E4N75_03455	COG0823	Involved in the tonB-independent uptake of proteins
E4N75_03470	COG4254	PFAM FecR protein
E4N75_03505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N75_03510	COG1286	toxin biosynthetic process
E4N75_03525	COG2204	response regulator
E4N75_03530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N75_03545	COG0475	glutathione-regulated potassium exporter activity
E4N75_03550	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N75_03595	COG0456	acetyltransferase
E4N75_03605	COG0535	radical SAM domain protein
E4N75_03620	COG1234	tRNA 3'-trailer cleavage
E4N75_03635	COG0556	nucleotide-excision repair
E4N75_03640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N75_03640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N75_03645	COG0557	exoribonuclease II activity
E4N75_03670	COG4115	mRNA cleavage
E4N75_03685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N75_03720	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N75_03725	COG0640	Transcriptional regulator
E4N75_03730	COG2217	Heavy metal translocating P-type atpase
E4N75_03740	COG0564	pseudouridine synthase activity
E4N75_03755	COG4656	Part of a membrane complex involved in electron transport
E4N75_03790	COG0455	bacterial-type flagellum organization
E4N75_03805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N75_03805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N75_03820	COG0488	(ABC) transporter
E4N75_03830	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N75_03840	COG1078	dGTPase activity
E4N75_03885	COG0028	Belongs to the TPP enzyme family
E4N75_03885	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N75_03920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N75_03935	COG1216	Glycosyl transferase, family 2
E4N75_03970	COG1215	transferase activity, transferring glycosyl groups
E4N75_03985	COG1215	transferase activity, transferring glycosyl groups
E4N75_04000	COG1215	transferase activity, transferring glycosyl groups
E4N75_04030	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N75_04040	COG0463	Glycosyl transferase, family 2
E4N75_04050	COG0706	membrane insertase activity
E4N75_04055	COG0706	membrane insertase activity
E4N75_04065	COG0706	membrane insertase activity
E4N75_04075	COG0706	membrane insertase activity
E4N75_04080	COG0706	membrane insertase activity
E4N75_04095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N75_04110	COG0124	histidyl-tRNA synthetase
E4N75_04120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N75_04130	COG0488	(ABC) transporter
E4N75_04140	COG0793	Belongs to the peptidase S41A family
E4N75_04205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N75_04210	COG0632	four-way junction helicase activity
E4N75_04285	COG1136	(ABC) transporter
E4N75_04400	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N75_04410	COG2361	Protein of unknown function DUF86
E4N75_04445	COG0539	negative regulation of cytoplasmic translation
E4N75_04555	COG4115	mRNA cleavage
E4N75_04620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N75_04625	COG2878	Part of a membrane complex involved in electron transport
E4N75_04630	COG0481	GTPase activity
E4N75_04675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_04705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N75_04715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N75_04720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N75_04735	COG0799	negative regulation of ribosome biogenesis
E4N75_04740	COG2059	Chromate
E4N75_04750	COG0484	heat shock protein binding
E4N75_04755	COG0024	Methionine aminopeptidase
E4N75_04760	COG0708	Exodeoxyribonuclease III
E4N75_04775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N75_04785	COG0739	heme binding
E4N75_04860	COG0617	tRNA 3'-terminal CCA addition
E4N75_04890	COG1846	Transcriptional regulator
E4N75_04895	COG0519	Catalyzes the synthesis of GMP from XMP
E4N75_04910	COG0126	phosphoglycerate kinase activity
E4N75_04915	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N75_04935	COG0268	Binds directly to 16S ribosomal RNA
E4N75_04945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N75_04955	COG1058	Belongs to the CinA family
E4N75_04955	COG1546	Belongs to the CinA family
E4N75_05005	COG1131	(ABC) transporter
E4N75_05015	COG0457	Tetratricopeptide repeat
E4N75_05020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N75_05025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N75_05030	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N75_05035	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N75_05040	COG1394	ATPase activity, coupled to movement of substances
E4N75_05045	COG1269	ATP hydrolysis coupled proton transport
E4N75_05055	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N75_05060	COG0629	single-stranded DNA binding
E4N75_05065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N75_05070	COG0359	binds to the 23S rRNA
E4N75_05080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N75_05085	COG0740	serine-type endopeptidase activity
E4N75_05090	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N75_05110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_05120	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N75_05135	COG2885	chlorophyll binding
E4N75_05140	COG0305	Participates in initiation and elongation during chromosome replication
E4N75_05150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N75_05165	COG2826	transposase and inactivated derivatives, IS30 family
E4N75_05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N75_05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N75_05245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N75_05250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N75_05255	COG2033	superoxide reductase activity
E4N75_05295	COG0497	DNA recombination
E4N75_05315	COG0791	NLP P60 protein
E4N75_05315	COG1388	LysM domain
E4N75_05330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N75_05335	COG0312	modulator of DNA gyrase
E4N75_05340	COG0312	modulator of DNA gyrase
E4N75_05355	COG1692	metallophosphoesterase
E4N75_05365	COG0142	geranyltranstransferase activity
E4N75_05370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N75_05390	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N75_05405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N75_05425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N75_05440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4N75_05445	COG2721	sulfolactate sulfo-lyase activity
E4N75_05455	COG1349	DNA-binding transcription factor activity
E4N75_05460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_05495	COG1047	Peptidyl-prolyl cis-trans
E4N75_05510	COG0731	radical SAM domain protein
E4N75_05525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N75_05530	COG1979	alcohol dehydrogenase
E4N75_05535	COG2255	four-way junction helicase activity
E4N75_05545	COG1725	Transcriptional regulator
E4N75_05555	COG0653	protein targeting
E4N75_05560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N75_05565	COG0138	bifunctional purine biosynthesis protein purh
E4N75_05570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N75_05575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N75_05580	COG0205	6-phosphofructokinase activity
E4N75_05585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_05605	COG2982	Protein involved in outer membrane biogenesis
E4N75_05615	COG0297	glycogen (starch) synthase activity
E4N75_05630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N75_05640	COG0835	chemotaxis
E4N75_05650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N75_05655	COG0488	(ABC) transporter
E4N75_05665	COG0493	'glutamate synthase
E4N75_05665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N75_05670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N75_05710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N75_05730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N75_05760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N75_05765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N75_05770	COG0509	glycine decarboxylation via glycine cleavage system
E4N75_05775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N75_05785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N75_05820	COG3052	prosthetic group binding
E4N75_05830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N75_05830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N75_05830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N75_05835	COG0237	dephospho-CoA kinase activity
E4N75_05845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N75_05850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N75_05870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N75_05885	COG1122	ATPase activity
E4N75_05890	COG1268	BioY protein
E4N75_05915	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N75_05945	COG1136	(ABC) transporter
E4N75_05950	COG0577	efflux transmembrane transporter activity
E4N75_05970	COG3470	protein probably involved in high-affinity Fe2 transport
E4N75_05985	COG1136	(ABC) transporter
E4N75_05995	COG1760	l-serine dehydratase
E4N75_06000	COG1760	l-serine dehydratase
E4N75_06010	COG0254	rRNA binding
E4N75_06015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N75_06030	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_06030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_06040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N75_06060	COG1196	nuclear chromosome segregation
E4N75_06070	COG2201	protein-glutamate methylesterase activity
E4N75_06080	COG0835	chemotaxis
E4N75_06085	COG2198	Histidine kinase
E4N75_06085	COG0643	Histidine kinase
E4N75_06100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N75_06105	COG0217	transcriptional regulatory protein
E4N75_06140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_06150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_06165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N75_06165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N75_06180	COG0802	atpase or kinase
E4N75_06190	COG2770	Histidine kinase
E4N75_06190	COG3437	response regulator, receiver
E4N75_06195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N75_06200	COG0681	Belongs to the peptidase S26 family
E4N75_06205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N75_06230	COG0330	HflC and HflK could
E4N75_06235	COG0330	HflC and HflK could
E4N75_06245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N75_06275	COG1739	Uncharacterized protein family UPF0029
E4N75_06305	COG0768	penicillin binding
E4N75_06310	COG0681	Belongs to the peptidase S26 family
E4N75_06330	COG0009	L-threonylcarbamoyladenylate synthase
E4N75_06370	COG2211	Major facilitator Superfamily
E4N75_06370	COG2190	(PTS) system
E4N75_06395	COG1162	GTPase activity
E4N75_06405	COG1132	(ABC) transporter
E4N75_06410	COG1132	(ABC) transporter
E4N75_06415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N75_06430	COG4166	transmembrane transport
E4N75_06450	COG0525	valine-tRNA ligase activity
E4N75_06455	COG2252	PERMEase
E4N75_06480	COG0772	Belongs to the SEDS family
E4N75_06485	COG0768	penicillin binding
E4N75_06500	COG1077	Cell shape determining protein MreB Mrl
E4N75_06520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_06525	COG0358	DNA primase activity
E4N75_06530	COG0606	chelatase, subunit chli
E4N75_06545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N75_06550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N75_06560	COG1164	Oligoendopeptidase f
E4N75_06605	COG2375	cellular response to nickel ion
E4N75_06605	COG1132	(ABC) transporter
E4N75_06615	COG1132	(ABC) transporter
E4N75_06795	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4N75_06840	COG0084	hydrolase, TatD family'
E4N75_06850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N75_06860	COG0438	transferase activity, transferring glycosyl groups
E4N75_06865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N75_06875	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N75_06880	COG3880	PFAM UvrB UvrC protein
E4N75_06890	COG1136	(ABC) transporter
E4N75_06895	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N75_06905	COG0552	protein localization to endoplasmic reticulum
E4N75_06920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N75_06955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N75_06960	COG4475	Protein of unknown function (DUF436)
E4N75_06985	COG0601	transmembrane transport
E4N75_06990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_07000	COG0444	Belongs to the ABC transporter superfamily
E4N75_07005	COG4608	Belongs to the ABC transporter superfamily
E4N75_07040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N75_07045	COG3118	belongs to the thioredoxin family
E4N75_07050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_07055	COG0457	Tetratricopeptide repeat
E4N75_07060	COG0037	tRNA processing
E4N75_07065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N75_07075	COG2088	sporulation resulting in formation of a cellular spore
E4N75_07080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N75_07105	COG0295	cytidine deaminase activity
E4N75_07215	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N75_07220	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N75_07225	COG3845	ABC transporter
E4N75_07230	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N75_07235	COG1363	Peptidase, m42
E4N75_07240	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N75_07255	COG0740	serine-type endopeptidase activity
E4N75_07270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N75_07290	COG0706	membrane insertase activity
E4N75_07300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N75_07310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N75_07320	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N75_07325	COG1121	(ABC) transporter
E4N75_07330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_07335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_07345	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N75_07360	COG1157	protein secretion by the type III secretion system
E4N75_07365	COG1317	bacterial-type flagellum organization
E4N75_07375	COG1766	The M ring may be actively involved in energy transduction
E4N75_07380	COG1677	Flagellar hook-basal body complex protein FliE
E4N75_07395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N75_07400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N75_07405	COG4974	Belongs to the 'phage' integrase family
E4N75_07410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N75_07410	COG0551	DNA topoisomerase type I activity
E4N75_07415	COG0758	DNA mediated transformation
E4N75_07430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N75_07445	COG0772	Belongs to the SEDS family
E4N75_07450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N75_07460	COG0275	rRNA processing
E4N75_07465	COG2001	Belongs to the MraZ family
E4N75_07470	COG1505	serine-type exopeptidase activity
E4N75_07515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N75_07530	COG0495	leucyl-tRNA aminoacylation
E4N75_07540	COG0750	zinc metalloprotease
E4N75_07545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N75_07555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N75_07560	COG0233	cytoplasmic translational termination
E4N75_07565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N75_07570	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N75_07575	COG0424	maF-like protein
E4N75_07580	COG1413	lyase activity
E4N75_07600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_07605	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N75_07610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N75_07620	COG0739	heme binding
E4N75_07620	COG0741	lytic transglycosylase activity
E4N75_07620	COG1196	nuclear chromosome segregation
E4N75_07645	COG0668	transmembrane transport
E4N75_07660	COG0840	transmembrane signaling receptor activity
E4N75_07675	COG4166	transmembrane transport
E4N75_07680	COG0601	transmembrane transport
E4N75_07685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_07690	COG0444	Belongs to the ABC transporter superfamily
E4N75_07695	COG4172	Belongs to the ABC transporter superfamily
E4N75_07700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N75_07730	COG0425	Belongs to the sulfur carrier protein TusA family
E4N75_07750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N75_07755	COG1126	abc transporter atp-binding protein
E4N75_07765	COG0765	amino acid transport
E4N75_07770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_07790	COG0601	transmembrane transport
E4N75_07795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_07800	COG0444	Belongs to the ABC transporter superfamily
E4N75_07805	COG4608	Belongs to the ABC transporter superfamily
E4N75_07850	COG0534	Mate efflux family protein
E4N75_07855	COG0840	transmembrane signaling receptor activity
E4N75_07860	COG1757	Na H antiporter
E4N75_07865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_07870	COG3290	protein histidine kinase activity
E4N75_07870	COG3829	transcription factor binding
E4N75_07895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_07900	COG0049	tRNA binding
E4N75_07905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N75_07925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N75_07930	COG0626	cystathionine gamma-synthase activity
E4N75_07945	COG1757	Na H antiporter
E4N75_07985	COG1122	ATPase activity
E4N75_08020	COG1770	oligopeptidase
E4N75_08025	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_08025	COG1902	pentaerythritol trinitrate reductase activity
E4N75_08040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N75_08050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_08060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N75_08085	COG0598	Magnesium transport protein CorA
E4N75_08090	COG0617	tRNA 3'-terminal CCA addition
E4N75_08105	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N75_08110	COG0571	ribonuclease III activity
E4N75_08115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N75_08120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N75_08130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N75_08150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N75_08150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N75_08160	COG1570	exodeoxyribonuclease VII activity
E4N75_08180	COG2703	oxygen carrier activity
E4N75_08195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N75_08200	COG1722	exodeoxyribonuclease VII activity
E4N75_08205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N75_08245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N75_08255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N75_08260	COG0085	RNA polymerase activity
E4N75_08265	COG0222	ribosome binding
E4N75_08270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N75_08275	COG0081	regulation of translation
E4N75_08280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N75_08285	COG0250	Participates in transcription elongation, termination and antitermination
E4N75_08290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N75_08300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N75_08330	COG1652	LysM domain
E4N75_08350	COG0326	Molecular chaperone. Has ATPase activity
E4N75_08360	COG0210	DNA helicase
E4N75_08365	COG1132	(ABC) transporter
E4N75_08370	COG1132	(ABC) transporter
E4N75_08375	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N75_08390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N75_08395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N75_08405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N75_08410	COG0840	transmembrane signaling receptor activity
E4N75_08430	COG3956	TIGRFAM MazG family protein
E4N75_08435	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N75_08455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N75_08475	COG1132	(ABC) transporter
E4N75_08480	COG1132	(ABC) transporter
E4N75_08485	COG1012	belongs to the aldehyde dehydrogenase family
E4N75_08490	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N75_08550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N75_08575	COG1120	ATPase activity
E4N75_08580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_08585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N75_08595	COG4865	methylaspartate mutase activity
E4N75_08600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N75_08615	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N75_08635	COG1131	(ABC) transporter
E4N75_08640	COG2208	phosphoserine phosphatase activity
E4N75_08640	COG2770	Histidine kinase
E4N75_08660	COG1126	abc transporter atp-binding protein
E4N75_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_08695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N75_08710	COG1272	protein, Hemolysin III
E4N75_08715	COG3177	Filamentation induced by cAMP protein fic
E4N75_08720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N75_08740	COG2378	regulation of single-species biofilm formation
E4N75_08775	COG4115	mRNA cleavage
E4N75_08785	COG2885	chlorophyll binding
E4N75_08790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N75_08790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N75_08790	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N75_08790	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N75_08795	COG0737	Belongs to the 5'-nucleotidase family
E4N75_08835	COG0148	phosphopyruvate hydratase activity
E4N75_08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N75_08850	COG2738	Putative neutral zinc metallopeptidase
E4N75_08920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N75_08925	COG0671	phosphoesterase, PA-phosphatase related
E4N75_08955	COG1475	DNA binding
E4N75_08965	COG0739	heme binding
E4N75_08970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N75_08970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N75_08985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N75_08990	COG0549	Belongs to the carbamate kinase family
E4N75_09005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N75_09015	COG1362	aminopeptidase activity
E4N75_09020	COG0445	tRNA wobble uridine modification
E4N75_09025	COG0210	DNA helicase
E4N75_09045	COG3604	Transcriptional regulator
E4N75_09085	COG1573	uracil-dna glycosylase
E4N75_09090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N75_09095	COG0196	riboflavin kinase activity
E4N75_09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N75_09105	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N75_09110	COG0756	dUTP diphosphatase activity
E4N75_09125	COG0564	pseudouridine synthase activity
E4N75_09130	COG0156	8-amino-7-oxononanoate synthase activity
E4N75_09160	COG1132	(ABC) transporter
E4N75_09165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N75_09170	COG1329	Transcriptional regulator
E4N75_09175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N75_09175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N75_09180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N75_09195	COG0668	transmembrane transport
E4N75_09210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_09215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N75_09220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_09235	COG0792	nuclease activity
E4N75_09250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N75_09270	COG1111	helicase
E4N75_09270	COG1205	dead DEAH box helicase
E4N75_09290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N75_09315	COG0504	CTP synthase activity
E4N75_09330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N75_09330	COG1747	RNA polymerase binding
E4N75_09345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N75_09360	COG5377	YqaJ viral recombinase family
E4N75_09485	COG0629	single-stranded DNA binding
E4N75_09875	COG0330	HflC and HflK could
E4N75_09895	COG1129	ABC transporter
E4N75_09925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N75_09935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N75_09945	COG4608	Belongs to the ABC transporter superfamily
E4N75_09950	COG0444	Belongs to the ABC transporter superfamily
E4N75_09960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_09965	COG0601	transmembrane transport
E4N75_09975	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N75_09980	COG4657	Part of a membrane complex involved in electron transport
E4N75_09985	COG4660	Part of a membrane complex involved in electron transport
E4N75_09995	COG4658	electron transport chain
E4N75_10000	COG4656	Part of a membrane complex involved in electron transport
E4N75_10010	COG2304	oxidoreductase activity
E4N75_10025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_10025	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_10035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N75_10045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4N75_10065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N75_10080	COG2197	response regulator
E4N75_10105	COG1187	pseudouridine synthase activity
E4N75_10110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N75_10170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N75_10185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N75_10190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N75_10200	COG2226	methyltransferase
E4N75_10220	COG1254	Belongs to the acylphosphatase family
E4N75_10245	COG0203	ribosomal protein L17
E4N75_10250	COG0202	RNA polymerase activity
E4N75_10255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N75_10260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N75_10265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N75_10275	COG0200	Binds to the 23S rRNA
E4N75_10280	COG1841	ribosomal large subunit assembly
E4N75_10285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N75_10290	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N75_10295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N75_10300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N75_10305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N75_10310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N75_10315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N75_10320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N75_10325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N75_10330	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N75_10335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N75_10340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N75_10345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N75_10350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N75_10355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N75_10360	COG0089	rRNA binding
E4N75_10365	COG0088	Forms part of the polypeptide exit tunnel
E4N75_10370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N75_10375	COG0051	transcription antitermination factor activity, RNA binding
E4N75_10380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N75_10400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N75_10410	COG3706	GGDEF domain
E4N75_10440	COG0564	pseudouridine synthase activity
E4N75_10450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N75_10455	COG0166	Belongs to the GPI family
E4N75_10460	COG1362	aminopeptidase activity
E4N75_10465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N75_10470	COG0724	RNA recognition motif
E4N75_10475	COG2211	Major facilitator Superfamily
E4N75_10520	COG1266	CAAX protease self-immunity
E4N75_10530	COG0396	ATPase activity
E4N75_10535	COG0719	Fe-S assembly protein
E4N75_10545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N75_10565	COG2201	protein-glutamate methylesterase activity
E4N75_10585	COG1137	ATPase activity
E4N75_10590	COG0193	aminoacyl-tRNA hydrolase activity
E4N75_10600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N75_10610	COG0601	transmembrane transport
E4N75_10615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_10620	COG0444	Belongs to the ABC transporter superfamily
E4N75_10625	COG4608	Belongs to the ABC transporter superfamily
E4N75_10630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N75_10635	COG1876	peptidase activity
E4N75_10655	COG0484	heat shock protein binding
E4N75_10660	COG0443	Heat shock 70 kDa protein
E4N75_10665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N75_10695	COG1120	ATPase activity
E4N75_10725	COG0534	Mate efflux family protein
E4N75_10750	COG1192	Involved in chromosome partitioning
E4N75_10755	COG1475	DNA binding
E4N75_10775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N75_10780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N75_10785	COG1028	Short-chain dehydrogenase reductase Sdr
E4N75_10800	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N75_10820	COG0439	Biotin carboxylase
E4N75_10830	COG0825	malonyl-CoA metabolic process
E4N75_10835	COG2986	histidine ammonia-lyase
E4N75_10850	COG0714	Associated with various cellular activities
E4N75_10890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N75_10895	COG0154	amidase activity
E4N75_10900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N75_10940	COG3209	COG3209 Rhs family protein
E4N75_11030	COG1136	(ABC) transporter
E4N75_11160	COG1396	sequence-specific DNA binding
E4N75_11170	COG3550	peptidyl-serine autophosphorylation
E4N75_11205	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N75_11260	COG1132	(ABC) transporter
E4N75_11265	COG1132	(ABC) transporter
E4N75_11270	COG0280	phosphate acetyltransferase
E4N75_11275	COG0457	Tetratricopeptide repeat
E4N75_11280	COG0587	DNA-directed DNA polymerase activity
E4N75_11315	COG3177	Filamentation induced by cAMP protein fic
E4N75_11330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4N75_11330	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4N75_11335	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_11345	COG4175	Glycine betaine
E4N75_11345	COG3448	diguanylate cyclase activity
E4N75_11355	COG2205	protein histidine kinase activity
E4N75_11360	COG1136	(ABC) transporter
E4N75_11370	COG0095	Lipoate-protein ligase
E4N75_11380	COG1131	(ABC) transporter
E4N75_11385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N75_11390	COG1122	ATPase activity
E4N75_11435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N75_11455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N75_11460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N75_11490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N75_11520	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N75_11535	COG1774	PSP1 C-terminal conserved region
E4N75_11540	COG1728	Protein conserved in bacteria
E4N75_11550	COG0739	heme binding
E4N75_11565	COG0366	Alpha amylase catalytic
E4N75_11575	COG1609	Transcriptional regulator
E4N75_11580	COG1129	ABC transporter
E4N75_11610	COG0543	2 iron, 2 sulfur cluster binding
E4N75_11615	COG3437	response regulator, receiver
E4N75_11615	COG0784	Response regulator, receiver
E4N75_11675	COG3177	Filamentation induced by cAMP protein fic
E4N75_11690	COG1129	ABC transporter
E4N75_11700	COG1132	(ABC) transporter
E4N75_11705	COG1309	transcriptional regulator
E4N75_11710	COG3189	MarR family transcriptional regulator
E4N75_11725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N75_11730	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N75_11735	COG1684	flagellar biosynthetic protein fliR
E4N75_11740	COG1987	bacterial-type flagellum assembly
E4N75_11765	COG1228	amidohydrolase
E4N75_11800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_11805	COG0583	DNA-binding transcription factor activity
E4N75_11815	COG0747	negative chemotaxis
E4N75_11820	COG4608	Belongs to the ABC transporter superfamily
E4N75_11825	COG0444	Belongs to the ABC transporter superfamily
E4N75_11830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_11855	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N75_11885	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N75_11895	COG4143	(ABC) transporter
E4N75_11910	COG1373	ATPase (AAA superfamily
E4N75_11920	COG1473	amidohydrolase
E4N75_11925	COG4585	Histidine kinase
E4N75_11930	COG2197	response regulator
E4N75_11935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_11965	COG0800	Aldolase
E4N75_12005	COG3093	addiction module antidote protein HigA
E4N75_12010	COG3549	Plasmid maintenance system killer
E4N75_12020	COG0728	peptidoglycan biosynthetic process
E4N75_12025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N75_12040	COG3588	fructose-bisphosphate aldolase
E4N75_12065	COG0012	GTP binding
E4N75_12070	COG0616	signal peptide processing
E4N75_12095	COG5012	cobalamin binding
E4N75_12100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N75_12105	COG1132	(ABC) transporter
E4N75_12110	COG1132	(ABC) transporter
E4N75_12120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_12125	COG0363	glucosamine-6-phosphate deaminase activity
E4N75_12135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N75_12140	COG0534	Mate efflux family protein
E4N75_12145	COG1309	transcriptional regulator
E4N75_12150	COG0786	glutamate:sodium symporter activity
E4N75_12155	COG0840	transmembrane signaling receptor activity
E4N75_12160	COG0840	transmembrane signaling receptor activity
E4N75_12165	COG0813	purine-nucleoside phosphorylase activity
E4N75_12210	COG5002	protein histidine kinase activity
E4N75_12210	COG5001	Diguanylate cyclase
E4N75_12215	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N75_12215	COG0540	Belongs to the ATCase OTCase family
E4N75_12250	COG3842	ATPase activity
E4N75_12255	COG3833	ABC-type maltose transport systems, permease component
E4N75_12260	COG1175	transmembrane transport
E4N75_12270	COG1418	mRNA catabolic process
E4N75_12275	COG0419	ATPase involved in DNA repair
E4N75_12280	COG0420	3'-5' exonuclease activity
E4N75_12285	COG0840	transmembrane signaling receptor activity
E4N75_12285	COG3290	protein histidine kinase activity
E4N75_12295	COG1131	(ABC) transporter
E4N75_12315	COG0716	FMN binding
E4N75_12330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N75_12335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N75_12340	COG0592	DNA-directed DNA polymerase activity
E4N75_12345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N75_12425	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4N75_12480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N75_12495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N75_12505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N75_12540	COG2184	nucleotidyltransferase activity
E4N75_12550	COG0730	response to heat
E4N75_12570	COG4208	sulfate ABC transporter
E4N75_12575	COG3839	Belongs to the ABC transporter superfamily
E4N75_12585	COG0840	transmembrane signaling receptor activity
E4N75_12600	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N75_12605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N75_12610	COG1674	ftsk spoiiie
E4N75_12625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_12650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N75_12655	COG0534	Mate efflux family protein
E4N75_12660	COG0569	domain protein
E4N75_12685	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N75_12690	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_12710	COG2235	arginine
E4N75_12715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N75_12725	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N75_12730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N75_12735	COG0569	domain protein
E4N75_12745	COG1487	ribonuclease activity
E4N75_12760	COG0714	Associated with various cellular activities
E4N75_12765	COG4536	flavin adenine dinucleotide binding
E4N75_12770	COG4536	flavin adenine dinucleotide binding
E4N75_12785	COG0514	ATP-dependent DNA helicase (RecQ)
E4N75_12795	COG1518	maintenance of DNA repeat elements
E4N75_12800	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N75_12815	COG1132	(ABC) transporter
E4N75_12820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N75_12840	COG3271	cysteine-type peptidase activity
E4N75_12840	COG2274	protein secretion by the type I secretion system
E4N75_12845	COG1132	(ABC) transporter
E4N75_12850	COG0438	transferase activity, transferring glycosyl groups
E4N75_12855	COG3842	ATPase activity
E4N75_12880	COG3706	GGDEF domain
E4N75_12890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N75_12895	COG0215	cysteine-tRNA ligase activity
E4N75_12910	COG1305	Transglutaminase-like
E4N75_12920	COG0569	domain protein
E4N75_12925	COG2887	Belongs to the helicase family. UvrD subfamily
E4N75_12940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N75_12990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N75_13000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N75_13010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N75_13020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N75_13035	COG1131	(ABC) transporter
E4N75_13050	COG0840	transmembrane signaling receptor activity
E4N75_13080	COG1151	hydroxylamine reductase activity
E4N75_13100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N75_13105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N75_13125	COG1401	restriction endodeoxyribonuclease activity
E4N75_13150	COG1104	cysteine desulfurase activity
E4N75_13155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N75_13160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N75_13180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N75_13195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N75_13205	COG1929	Belongs to the glycerate kinase type-1 family
E4N75_13220	COG0494	nUDIX hydrolase
E4N75_13225	COG0783	Belongs to the Dps family
E4N75_13230	COG0450	alkyl hydroperoxide reductase
E4N75_13235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N75_13250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N75_13255	COG1363	Peptidase, m42
E4N75_13265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N75_13270	COG0423	glycine-tRNA ligase activity
E4N75_13290	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N75_13400	COG1129	ABC transporter
E4N75_13415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N75_13455	COG1011	Hydrolase
E4N75_13475	COG1132	(ABC) transporter
E4N75_13480	COG2375	cellular response to nickel ion
E4N75_13480	COG1132	(ABC) transporter
E4N75_13510	COG0456	acetyltransferase
E4N75_13545	COG1129	ABC transporter
E4N75_13615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N75_13650	COG1191	sigma factor activity
E4N75_13665	COG1419	protein localization to endoplasmic reticulum
E4N75_13670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N75_13695	COG1132	(ABC) transporter
E4N75_13710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N75_13725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N75_13730	COG1360	Flagellar Motor Protein
E4N75_13735	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N75_13740	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_13745	COG1776	CheC inhibitor of MCP methylation
E4N75_13745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_13755	COG1338	Plays a role in the flagellum-specific transport system
E4N75_13780	COG4555	ABC transporter
E4N75_13840	COG0561	phosphatase activity
E4N75_13845	COG4166	transmembrane transport
E4N75_13850	COG2423	ornithine cyclodeaminase activity
E4N75_13855	COG1196	nuclear chromosome segregation
E4N75_13855	COG0739	heme binding
E4N75_13855	COG0741	lytic transglycosylase activity
E4N75_13860	COG4545	Glutaredoxin-related protein
E4N75_13875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N75_13890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N75_13890	COG3116	cell division
E4N75_13895	COG0084	hydrolase, TatD family'
E4N75_13905	COG2199	diguanylate cyclase activity
E4N75_13905	COG2203	Gaf domain