locus-tag	class	description
E4N76_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N76_00010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N76_00105	COG5005	Phage virion morphogenesis
E4N76_00135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4N76_00275	COG5377	YqaJ viral recombinase family
E4N76_00400	COG0629	single-stranded DNA binding
E4N76_00715	COG0577	efflux transmembrane transporter activity
E4N76_00715	COG1136	(ABC) transporter
E4N76_00720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N76_00745	COG1132	(ABC) transporter
E4N76_00805	COG1266	CAAX protease self-immunity
E4N76_00815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N76_00870	COG1012	belongs to the aldehyde dehydrogenase family
E4N76_00900	COG0531	amino acid
E4N76_00905	COG0196	riboflavin kinase activity
E4N76_00910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N76_00930	COG0840	transmembrane signaling receptor activity
E4N76_00935	COG0826	peptidase U32
E4N76_00945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N76_00950	COG1509	lysine 2,3-aminomutase activity
E4N76_00955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N76_00960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N76_00975	COG0205	6-phosphofructokinase activity
E4N76_01030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N76_01050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N76_01105	COG2823	Periplasmic or secreted lipoprotein
E4N76_01105	COG1652	LysM domain
E4N76_01115	COG1592	Rubrerythrin
E4N76_01120	COG0514	ATP-dependent DNA helicase (RecQ)
E4N76_01125	COG1381	Involved in DNA repair and RecF pathway recombination
E4N76_01135	COG0343	queuine tRNA-ribosyltransferase activity
E4N76_01175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N76_01190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N76_01200	COG4555	ABC transporter
E4N76_01215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N76_01220	COG2239	Acts as a magnesium transporter
E4N76_01230	COG0546	phosphoglycolate phosphatase activity
E4N76_01240	COG3118	belongs to the thioredoxin family
E4N76_01250	COG1120	ATPase activity
E4N76_01255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N76_01270	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N76_01270	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N76_01275	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N76_01315	COG1757	Na H antiporter
E4N76_01320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N76_01325	COG4443	Transcriptional Coactivator p15 (PC4)
E4N76_01330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N76_01335	COG0301	tRNA thio-modification
E4N76_01365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N76_01370	COG1121	(ABC) transporter
E4N76_01380	COG4988	ABC transporter
E4N76_01385	COG1132	(ABC) transporter
E4N76_01415	COG0335	large ribosomal subunit rRNA binding
E4N76_01420	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N76_01425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N76_01430	COG1837	Belongs to the UPF0109 family
E4N76_01435	COG0228	four-way junction DNA binding
E4N76_01455	COG1136	(ABC) transporter
E4N76_01455	COG0577	efflux transmembrane transporter activity
E4N76_01460	COG1136	(ABC) transporter
E4N76_01470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N76_01475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N76_01480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N76_01520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N76_01525	COG1285	pathogenesis
E4N76_01550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N76_01555	COG0534	Mate efflux family protein
E4N76_01560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N76_01565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N76_01570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N76_01585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N76_01595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N76_01600	COG0116	Belongs to the methyltransferase superfamily
E4N76_01605	COG3735	TraB family
E4N76_01615	COG0791	NLP P60 protein
E4N76_01620	COG0318	PFAM AMP-dependent synthetase and ligase
E4N76_01650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N76_01695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N76_01705	COG0732	type I restriction modification DNA specificity domain
E4N76_01710	COG4974	Belongs to the 'phage' integrase family
E4N76_01715	COG0732	type I restriction modification DNA specificity domain
E4N76_01735	COG1979	alcohol dehydrogenase
E4N76_01775	COG0583	DNA-binding transcription factor activity
E4N76_01780	COG0656	L-ascorbic acid biosynthetic process
E4N76_01805	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N76_01815	COG3340	Belongs to the peptidase S51 family
E4N76_01820	COG0698	ribose 5-phosphate isomerase
E4N76_01825	COG0039	L-malate dehydrogenase activity
E4N76_01830	COG0534	Mate efflux family protein
E4N76_01835	COG0574	Belongs to the PEP-utilizing enzyme family
E4N76_01835	COG3848	Pyruvate phosphate dikinase
E4N76_01840	COG1309	transcriptional regulator
E4N76_01855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N76_01875	COG1477	protein flavinylation
E4N76_01880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N76_01885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N76_01900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N76_01920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N76_01925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N76_01930	COG1862	Preprotein translocase
E4N76_01935	COG0629	single-stranded DNA binding
E4N76_01945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N76_01950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N76_01965	COG0482	sulfurtransferase activity
E4N76_01975	COG0351	phosphomethylpyrimidine kinase
E4N76_01985	COG1131	(ABC) transporter
E4N76_02010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N76_02015	COG0406	alpha-ribazole phosphatase activity
E4N76_02020	COG0322	excinuclease ABC activity
E4N76_02030	COG1921	L-seryl-tRNASec selenium transferase activity
E4N76_02050	COG0577	efflux transmembrane transporter activity
E4N76_02050	COG1136	(ABC) transporter
E4N76_02055	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N76_02075	COG1639	'signal transduction protein
E4N76_02085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N76_02095	COG0101	tRNA pseudouridine synthase activity
E4N76_02110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N76_02160	COG1132	(ABC) transporter
E4N76_02165	COG0657	acetylesterase activity
E4N76_02170	COG0826	peptidase U32
E4N76_02175	COG3142	Participates in the control of copper homeostasis
E4N76_02220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4N76_02220	COG0515	serine threonine protein kinase
E4N76_02240	COG3876	Protein conserved in bacteria
E4N76_02245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N76_02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N76_02270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N76_02275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N76_02280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N76_02285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N76_02290	COG0484	heat shock protein binding
E4N76_02295	COG0528	UMP kinase activity
E4N76_02300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N76_02315	COG0539	negative regulation of cytoplasmic translation
E4N76_02320	COG2204	response regulator
E4N76_02325	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N76_02345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N76_02370	COG0251	oxidation-reduction process
E4N76_02395	COG2197	response regulator
E4N76_02400	COG1131	(ABC) transporter
E4N76_02415	COG4585	Histidine kinase
E4N76_02420	COG0542	response to heat
E4N76_02450	COG2949	membrane
E4N76_02460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N76_02475	COG1692	metallophosphoesterase
E4N76_02485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N76_02495	COG0484	heat shock protein binding
E4N76_02500	COG2089	acid synthase
E4N76_02505	COG5341	Protein conserved in bacteria
E4N76_02510	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N76_02515	COG0584	glycerophosphoryl diester phosphodiesterase
E4N76_02520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N76_02525	COG1704	LemA family
E4N76_02530	COG0018	arginyl-trna synthetase
E4N76_02535	COG1040	competence protein
E4N76_02540	COG2003	Belongs to the UPF0758 family
E4N76_02545	COG1686	Belongs to the peptidase S11 family
E4N76_02550	COG0017	Asparaginyl-tRNA synthetase
E4N76_02560	COG2116	formate transmembrane transporter activity
E4N76_02565	COG2084	Dehydrogenase
E4N76_02570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N76_02595	COG4786	Flagellar basal body rod
E4N76_02605	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N76_02610	COG1690	Belongs to the RtcB family
E4N76_02640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N76_02720	COG1132	(ABC) transporter
E4N76_02725	COG1132	(ABC) transporter
E4N76_02745	COG1129	ABC transporter
E4N76_02775	COG1132	(ABC) transporter
E4N76_02780	COG1129	ABC transporter
E4N76_02800	COG5492	domain, Protein
E4N76_02810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N76_02825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N76_02850	COG2604	Protein of unknown function DUF115
E4N76_02880	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N76_02890	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N76_02910	COG0442	prolyl-tRNA aminoacylation
E4N76_02925	COG1879	ABC-type sugar transport system periplasmic component
E4N76_02950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N76_02955	COG0666	response to abiotic stimulus
E4N76_02960	COG3885	ferrous iron binding
E4N76_02960	COG2078	PFAM AMMECR1 domain protein
E4N76_02975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N76_02980	COG0281	malic enzyme
E4N76_03000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_03005	COG0444	Belongs to the ABC transporter superfamily
E4N76_03010	COG4608	Belongs to the ABC transporter superfamily
E4N76_03015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N76_03015	COG0426	domain, Protein
E4N76_03035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N76_03040	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N76_03055	COG0564	pseudouridine synthase activity
E4N76_03060	COG0285	dihydrofolate synthase activity
E4N76_03070	COG1561	YicC-like family, N-terminal region
E4N76_03075	COG1102	Psort location Cytoplasmic, score
E4N76_03080	COG3706	GGDEF domain
E4N76_03090	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N76_03115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N76_03120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N76_03145	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N76_03155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N76_03175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N76_03220	COG0410	ABC transporter
E4N76_03235	COG2376	Dihydroxyacetone kinase
E4N76_03240	COG2376	Dihydroxyacetone kinase
E4N76_03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N76_03280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N76_03285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N76_03290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N76_03300	COG0779	Required for maturation of 30S ribosomal subunits
E4N76_03320	COG0563	adenylate kinase activity
E4N76_03325	COG3033	Beta-eliminating lyase
E4N76_03345	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N76_03385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N76_03395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N76_03415	COG0459	protein refolding
E4N76_03435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N76_03445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N76_03460	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N76_03465	COG3681	Belongs to the UPF0597 family
E4N76_03470	COG4953	penicillin-binding protein 1C
E4N76_03480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N76_03485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N76_03495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N76_03500	COG1671	Belongs to the UPF0178 family
E4N76_03510	COG0741	lytic transglycosylase activity
E4N76_03510	COG1388	LysM domain
E4N76_03600	COG0058	SHG alpha-glucan phosphorylase activity
E4N76_03610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N76_03635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N76_03665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N76_03675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N76_03680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N76_03685	COG4750	Nucleotidyl transferase
E4N76_03690	COG1115	amino acid carrier protein
E4N76_03765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N76_03775	COG1702	phosphate starvation-inducible protein PhoH
E4N76_03790	COG0149	triose-phosphate isomerase activity
E4N76_03795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N76_03815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N76_03835	COG2885	chlorophyll binding
E4N76_03850	COG1199	ATP-dependent helicase activity
E4N76_03860	COG0823	Involved in the tonB-independent uptake of proteins
E4N76_03875	COG4254	PFAM FecR protein
E4N76_03915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N76_03920	COG1286	toxin biosynthetic process
E4N76_03925	COG0470	DNA polymerase III
E4N76_03930	COG3852	Histidine kinase
E4N76_03935	COG2204	response regulator
E4N76_03940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N76_03955	COG0475	glutathione-regulated potassium exporter activity
E4N76_03960	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N76_04010	COG0456	acetyltransferase
E4N76_04020	COG0535	radical SAM domain protein
E4N76_04035	COG1733	regulation of RNA biosynthetic process
E4N76_04050	COG1234	tRNA 3'-trailer cleavage
E4N76_04065	COG0556	nucleotide-excision repair
E4N76_04070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N76_04070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N76_04075	COG0557	exoribonuclease II activity
E4N76_04100	COG4115	mRNA cleavage
E4N76_04105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N76_04130	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N76_04135	COG0640	Transcriptional regulator
E4N76_04140	COG2217	Heavy metal translocating P-type atpase
E4N76_04155	COG0564	pseudouridine synthase activity
E4N76_04170	COG4656	Part of a membrane complex involved in electron transport
E4N76_04205	COG0455	bacterial-type flagellum organization
E4N76_04215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N76_04220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N76_04220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N76_04235	COG0488	(ABC) transporter
E4N76_04245	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N76_04255	COG1078	dGTPase activity
E4N76_04280	COG0475	glutathione-regulated potassium exporter activity
E4N76_04300	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N76_04300	COG0028	Belongs to the TPP enzyme family
E4N76_04305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4N76_04345	COG0463	Glycosyl transferase, family 2
E4N76_04380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N76_04390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N76_04410	COG1216	Glycosyl transferase, family 2
E4N76_04415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N76_04460	COG1086	Polysaccharide biosynthesis protein
E4N76_04475	COG1216	Glycosyl transferase, family 2
E4N76_04475	COG0463	Glycosyl transferase, family 2
E4N76_04490	COG0463	Glycosyl transferase, family 2
E4N76_04495	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N76_04505	COG0463	Glycosyl transferase, family 2
E4N76_04515	COG0706	membrane insertase activity
E4N76_04520	COG0706	membrane insertase activity
E4N76_04530	COG0706	membrane insertase activity
E4N76_04540	COG0706	membrane insertase activity
E4N76_04545	COG0706	membrane insertase activity
E4N76_04560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N76_04575	COG0124	histidyl-tRNA synthetase
E4N76_04585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N76_04595	COG0488	(ABC) transporter
E4N76_04605	COG0793	Belongs to the peptidase S41A family
E4N76_04660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N76_04665	COG0632	four-way junction helicase activity
E4N76_04735	COG1136	(ABC) transporter
E4N76_04815	COG2361	Protein of unknown function DUF86
E4N76_04850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N76_04855	COG1122	ATPase activity
E4N76_04930	COG2361	Protein of unknown function DUF86
E4N76_04975	COG0561	phosphatase activity
E4N76_05005	COG2361	Protein of unknown function DUF86
E4N76_05015	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N76_05025	COG2361	Protein of unknown function DUF86
E4N76_05055	COG4115	mRNA cleavage
E4N76_05065	COG2361	Protein of unknown function DUF86
E4N76_05130	COG1733	regulation of RNA biosynthetic process
E4N76_05150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N76_05155	COG2878	Part of a membrane complex involved in electron transport
E4N76_05160	COG0481	GTPase activity
E4N76_05190	COG1114	Component of the transport system for branched-chain amino acids
E4N76_05205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N76_05230	COG2723	6-phospho-beta-galactosidase activity
E4N76_05235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N76_05245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N76_05250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N76_05265	COG0799	negative regulation of ribosome biogenesis
E4N76_05270	COG2059	Chromate
E4N76_05280	COG0484	heat shock protein binding
E4N76_05285	COG0024	Methionine aminopeptidase
E4N76_05290	COG0708	Exodeoxyribonuclease III
E4N76_05305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N76_05315	COG0739	heme binding
E4N76_05380	COG0617	tRNA 3'-terminal CCA addition
E4N76_05410	COG1846	Transcriptional regulator
E4N76_05415	COG0519	Catalyzes the synthesis of GMP from XMP
E4N76_05430	COG0126	phosphoglycerate kinase activity
E4N76_05435	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N76_05455	COG0268	Binds directly to 16S ribosomal RNA
E4N76_05465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N76_05475	COG1546	Belongs to the CinA family
E4N76_05475	COG1058	Belongs to the CinA family
E4N76_05505	COG0588	phosphoglycerate mutase activity
E4N76_05530	COG1131	(ABC) transporter
E4N76_05540	COG0457	Tetratricopeptide repeat
E4N76_05545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N76_05550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N76_05555	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N76_05560	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N76_05565	COG1394	ATPase activity, coupled to movement of substances
E4N76_05570	COG1269	ATP hydrolysis coupled proton transport
E4N76_05580	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N76_05585	COG0629	single-stranded DNA binding
E4N76_05590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N76_05595	COG0359	binds to the 23S rRNA
E4N76_05605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N76_05610	COG0740	serine-type endopeptidase activity
E4N76_05615	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N76_05635	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N76_05645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N76_05660	COG2885	chlorophyll binding
E4N76_05665	COG0305	Participates in initiation and elongation during chromosome replication
E4N76_05725	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N76_05730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N76_05735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N76_05765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N76_05770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N76_05775	COG2033	superoxide reductase activity
E4N76_05815	COG0497	DNA recombination
E4N76_05835	COG1388	LysM domain
E4N76_05835	COG0791	NLP P60 protein
E4N76_05845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N76_05850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N76_05855	COG0312	modulator of DNA gyrase
E4N76_05860	COG0312	modulator of DNA gyrase
E4N76_05875	COG1692	metallophosphoesterase
E4N76_05885	COG0142	geranyltranstransferase activity
E4N76_05890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N76_05910	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N76_05925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N76_05945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N76_05960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4N76_05965	COG2721	sulfolactate sulfo-lyase activity
E4N76_05975	COG1349	DNA-binding transcription factor activity
E4N76_05980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N76_06015	COG1047	Peptidyl-prolyl cis-trans
E4N76_06030	COG0731	radical SAM domain protein
E4N76_06045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N76_06050	COG1979	alcohol dehydrogenase
E4N76_06055	COG2255	four-way junction helicase activity
E4N76_06065	COG1725	Transcriptional regulator
E4N76_06075	COG0653	protein targeting
E4N76_06080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N76_06085	COG0138	bifunctional purine biosynthesis protein purh
E4N76_06090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N76_06095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N76_06100	COG0205	6-phosphofructokinase activity
E4N76_06105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N76_06125	COG2982	Protein involved in outer membrane biogenesis
E4N76_06130	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N76_06135	COG0297	glycogen (starch) synthase activity
E4N76_06160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N76_06170	COG0835	chemotaxis
E4N76_06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N76_06185	COG0488	(ABC) transporter
E4N76_06195	COG0493	'glutamate synthase
E4N76_06195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N76_06200	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N76_06205	COG1129	ABC transporter
E4N76_06255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N76_06275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N76_06300	COG1002	Type II restriction enzyme, methylase subunits
E4N76_06310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N76_06315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N76_06320	COG0509	glycine decarboxylation via glycine cleavage system
E4N76_06325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N76_06335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N76_06370	COG3052	prosthetic group binding
E4N76_06380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N76_06380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N76_06380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N76_06385	COG0237	dephospho-CoA kinase activity
E4N76_06395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N76_06400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N76_06415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N76_06430	COG1122	ATPase activity
E4N76_06435	COG1268	BioY protein
E4N76_06460	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N76_06500	COG1136	(ABC) transporter
E4N76_06505	COG0577	efflux transmembrane transporter activity
E4N76_06525	COG3470	protein probably involved in high-affinity Fe2 transport
E4N76_06530	COG0672	)-iron permease
E4N76_06535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4N76_06540	COG1136	(ABC) transporter
E4N76_06550	COG1760	l-serine dehydratase
E4N76_06555	COG1760	l-serine dehydratase
E4N76_06565	COG0254	rRNA binding
E4N76_06570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N76_06585	COG0574	Belongs to the PEP-utilizing enzyme family
E4N76_06585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N76_06595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N76_06605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N76_06615	COG1196	nuclear chromosome segregation
E4N76_06625	COG2201	protein-glutamate methylesterase activity
E4N76_06635	COG0835	chemotaxis
E4N76_06640	COG0643	Histidine kinase
E4N76_06640	COG2198	Histidine kinase
E4N76_06655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N76_06660	COG0217	transcriptional regulatory protein
E4N76_06695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N76_06705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N76_06720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N76_06720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N76_06735	COG0802	atpase or kinase
E4N76_06745	COG2770	Histidine kinase
E4N76_06745	COG3437	response regulator, receiver
E4N76_06750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N76_06755	COG0681	Belongs to the peptidase S26 family
E4N76_06760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N76_06795	COG0330	HflC and HflK could
E4N76_06800	COG0330	HflC and HflK could
E4N76_06810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N76_06840	COG1739	Uncharacterized protein family UPF0029
E4N76_06870	COG0768	penicillin binding
E4N76_06880	COG0433	COG0433 Predicted ATPase
E4N76_06895	COG0009	L-threonylcarbamoyladenylate synthase
E4N76_06940	COG2190	(PTS) system
E4N76_06940	COG2211	Major facilitator Superfamily
E4N76_06960	COG1193	negative regulation of DNA recombination
E4N76_06965	COG1162	GTPase activity
E4N76_06970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N76_06980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N76_06995	COG4166	transmembrane transport
E4N76_07015	COG0525	valine-tRNA ligase activity
E4N76_07020	COG2252	PERMEase
E4N76_07045	COG0772	Belongs to the SEDS family
E4N76_07050	COG0768	penicillin binding
E4N76_07065	COG1077	Cell shape determining protein MreB Mrl
E4N76_07085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N76_07090	COG0358	DNA primase activity
E4N76_07095	COG0606	chelatase, subunit chli
E4N76_07110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N76_07115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N76_07125	COG1164	Oligoendopeptidase f
E4N76_07170	COG2375	cellular response to nickel ion
E4N76_07170	COG1132	(ABC) transporter
E4N76_07180	COG1132	(ABC) transporter
E4N76_07410	COG2885	chlorophyll binding
E4N76_07415	COG0084	hydrolase, TatD family'
E4N76_07425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N76_07435	COG0438	transferase activity, transferring glycosyl groups
E4N76_07440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N76_07450	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N76_07455	COG3880	PFAM UvrB UvrC protein
E4N76_07465	COG1136	(ABC) transporter
E4N76_07470	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N76_07480	COG0552	protein localization to endoplasmic reticulum
E4N76_07495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N76_07560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N76_07565	COG4475	Protein of unknown function (DUF436)
E4N76_07580	COG0601	transmembrane transport
E4N76_07585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_07595	COG0444	Belongs to the ABC transporter superfamily
E4N76_07600	COG4608	Belongs to the ABC transporter superfamily
E4N76_07630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N76_07640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N76_07645	COG3118	belongs to the thioredoxin family
E4N76_07650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N76_07655	COG0457	Tetratricopeptide repeat
E4N76_07660	COG0037	tRNA processing
E4N76_07665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N76_07675	COG2088	sporulation resulting in formation of a cellular spore
E4N76_07680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N76_07705	COG0295	cytidine deaminase activity
E4N76_07785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N76_07815	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N76_07820	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N76_07825	COG3845	ABC transporter
E4N76_07830	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N76_07835	COG1363	Peptidase, m42
E4N76_07840	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N76_07855	COG0740	serine-type endopeptidase activity
E4N76_07870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N76_07885	COG1847	R3H domain protein
E4N76_07890	COG0706	membrane insertase activity
E4N76_07900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N76_07910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N76_07920	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N76_07925	COG1121	(ABC) transporter
E4N76_07930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N76_07935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N76_07945	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N76_07960	COG1157	protein secretion by the type III secretion system
E4N76_07965	COG1317	bacterial-type flagellum organization
E4N76_07975	COG1766	The M ring may be actively involved in energy transduction
E4N76_07980	COG1677	Flagellar hook-basal body complex protein FliE
E4N76_07995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N76_08000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N76_08005	COG4974	Belongs to the 'phage' integrase family
E4N76_08010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N76_08010	COG0551	DNA topoisomerase type I activity
E4N76_08015	COG0758	DNA mediated transformation
E4N76_08030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N76_08045	COG0772	Belongs to the SEDS family
E4N76_08050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N76_08060	COG0275	rRNA processing
E4N76_08065	COG2001	Belongs to the MraZ family
E4N76_08070	COG1505	serine-type exopeptidase activity
E4N76_08120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N76_08135	COG0495	leucyl-tRNA aminoacylation
E4N76_08145	COG0750	zinc metalloprotease
E4N76_08150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N76_08155	COG0575	Belongs to the CDS family
E4N76_08160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N76_08165	COG0233	cytoplasmic translational termination
E4N76_08170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N76_08175	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N76_08180	COG0424	maF-like protein
E4N76_08185	COG1413	lyase activity
E4N76_08205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N76_08210	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N76_08215	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N76_08225	COG0739	heme binding
E4N76_08225	COG0741	lytic transglycosylase activity
E4N76_08225	COG1196	nuclear chromosome segregation
E4N76_08250	COG0668	transmembrane transport
E4N76_08265	COG0840	transmembrane signaling receptor activity
E4N76_08280	COG4166	transmembrane transport
E4N76_08285	COG0601	transmembrane transport
E4N76_08290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_08295	COG0444	Belongs to the ABC transporter superfamily
E4N76_08300	COG4172	Belongs to the ABC transporter superfamily
E4N76_08305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N76_08335	COG0425	Belongs to the sulfur carrier protein TusA family
E4N76_08355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N76_08360	COG1126	abc transporter atp-binding protein
E4N76_08370	COG0765	amino acid transport
E4N76_08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N76_08390	COG0601	transmembrane transport
E4N76_08395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_08400	COG0444	Belongs to the ABC transporter superfamily
E4N76_08405	COG4608	Belongs to the ABC transporter superfamily
E4N76_08425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N76_08425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N76_08455	COG0534	Mate efflux family protein
E4N76_08460	COG0840	transmembrane signaling receptor activity
E4N76_08465	COG1757	Na H antiporter
E4N76_08470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N76_08475	COG3829	transcription factor binding
E4N76_08475	COG3290	protein histidine kinase activity
E4N76_08500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N76_08505	COG0049	tRNA binding
E4N76_08510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N76_08525	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N76_08525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N76_08525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N76_08525	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N76_08530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N76_08535	COG0626	cystathionine gamma-synthase activity
E4N76_08550	COG1757	Na H antiporter
E4N76_08590	COG1122	ATPase activity
E4N76_08625	COG1770	oligopeptidase
E4N76_08660	COG1122	ATPase activity
E4N76_08695	COG1770	oligopeptidase
E4N76_08715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N76_08735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N76_08760	COG0598	Magnesium transport protein CorA
E4N76_08765	COG0617	tRNA 3'-terminal CCA addition
E4N76_08780	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N76_08785	COG0571	ribonuclease III activity
E4N76_08790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N76_08795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N76_08805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N76_08825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N76_08825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N76_08835	COG1570	exodeoxyribonuclease VII activity
E4N76_08840	COG1067	ATP-dependent peptidase activity
E4N76_08855	COG2703	oxygen carrier activity
E4N76_08860	COG2183	response to ionizing radiation
E4N76_08870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N76_08875	COG1722	exodeoxyribonuclease VII activity
E4N76_08880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N76_08920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N76_08930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N76_08935	COG0085	RNA polymerase activity
E4N76_08940	COG0222	ribosome binding
E4N76_08945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N76_08950	COG0081	regulation of translation
E4N76_08955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N76_08960	COG0250	Participates in transcription elongation, termination and antitermination
E4N76_08965	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N76_08975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N76_09005	COG1652	LysM domain
E4N76_09025	COG0326	Molecular chaperone. Has ATPase activity
E4N76_09035	COG0210	DNA helicase
E4N76_09040	COG1132	(ABC) transporter
E4N76_09045	COG1132	(ABC) transporter
E4N76_09050	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N76_09065	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N76_09070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N76_09080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N76_09085	COG0840	transmembrane signaling receptor activity
E4N76_09105	COG3956	TIGRFAM MazG family protein
E4N76_09110	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N76_09130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N76_09150	COG1132	(ABC) transporter
E4N76_09155	COG1132	(ABC) transporter
E4N76_09160	COG1012	belongs to the aldehyde dehydrogenase family
E4N76_09165	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N76_09200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N76_09220	COG1120	ATPase activity
E4N76_09225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N76_09230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N76_09240	COG4865	methylaspartate mutase activity
E4N76_09245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N76_09255	COG0513	Belongs to the DEAD box helicase family
E4N76_09260	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N76_09280	COG1131	(ABC) transporter
E4N76_09285	COG2770	Histidine kinase
E4N76_09285	COG2208	phosphoserine phosphatase activity
E4N76_09325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N76_09340	COG1272	protein, Hemolysin III
E4N76_09345	COG3177	Filamentation induced by cAMP protein fic
E4N76_09350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N76_09365	COG2378	regulation of single-species biofilm formation
E4N76_09390	COG4115	mRNA cleavage
E4N76_09400	COG2885	chlorophyll binding
E4N76_09405	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N76_09405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N76_09405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N76_09405	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N76_09410	COG0737	Belongs to the 5'-nucleotidase family
E4N76_09450	COG0148	phosphopyruvate hydratase activity
E4N76_09455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N76_09465	COG2738	Putative neutral zinc metallopeptidase
E4N76_09480	COG2226	methyltransferase
E4N76_09535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N76_09540	COG0671	phosphoesterase, PA-phosphatase related
E4N76_09565	COG1022	Amp-dependent synthetase and ligase
E4N76_09570	COG1475	DNA binding
E4N76_09580	COG0739	heme binding
E4N76_09585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N76_09585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N76_09600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N76_09605	COG0549	Belongs to the carbamate kinase family
E4N76_09610	COG0534	Mate efflux family protein
E4N76_09615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N76_09620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N76_09630	COG1362	aminopeptidase activity
E4N76_09660	COG3604	Transcriptional regulator
E4N76_09715	COG0196	riboflavin kinase activity
E4N76_09720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N76_09725	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N76_09730	COG0756	dUTP diphosphatase activity
E4N76_09745	COG0564	pseudouridine synthase activity
E4N76_09750	COG0156	8-amino-7-oxononanoate synthase activity
E4N76_09770	COG1132	(ABC) transporter
E4N76_09775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N76_09780	COG1329	Transcriptional regulator
E4N76_09785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N76_09785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N76_09790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N76_09805	COG0668	transmembrane transport
E4N76_09820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N76_09825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N76_09830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N76_09845	COG0792	nuclease activity
E4N76_09860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N76_09875	COG1205	dead DEAH box helicase
E4N76_09875	COG1111	helicase
E4N76_09895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N76_09925	COG0504	CTP synthase activity
E4N76_09940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N76_09940	COG1747	RNA polymerase binding
E4N76_09955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N76_10000	COG0330	HflC and HflK could
E4N76_10015	COG1132	(ABC) transporter
E4N76_10020	COG1129	ABC transporter
E4N76_10050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N76_10060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N76_10070	COG4608	Belongs to the ABC transporter superfamily
E4N76_10075	COG0444	Belongs to the ABC transporter superfamily
E4N76_10085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_10090	COG0601	transmembrane transport
E4N76_10100	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N76_10105	COG4657	Part of a membrane complex involved in electron transport
E4N76_10110	COG4660	Part of a membrane complex involved in electron transport
E4N76_10120	COG4658	electron transport chain
E4N76_10125	COG4656	Part of a membrane complex involved in electron transport
E4N76_10135	COG2304	oxidoreductase activity
E4N76_10150	COG0574	Belongs to the PEP-utilizing enzyme family
E4N76_10150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N76_10160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N76_10170	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4N76_10175	COG0840	transmembrane signaling receptor activity
E4N76_10190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N76_10205	COG2197	response regulator
E4N76_10230	COG1187	pseudouridine synthase activity
E4N76_10235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N76_10290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N76_10305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N76_10310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N76_10320	COG2226	methyltransferase
E4N76_10340	COG1254	Belongs to the acylphosphatase family
E4N76_10365	COG0203	ribosomal protein L17
E4N76_10370	COG0202	RNA polymerase activity
E4N76_10375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N76_10380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N76_10385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N76_10395	COG0200	Binds to the 23S rRNA
E4N76_10400	COG1841	ribosomal large subunit assembly
E4N76_10405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N76_10410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N76_10415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N76_10420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N76_10425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N76_10430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N76_10435	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N76_10440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N76_10445	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N76_10450	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N76_10455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N76_10460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N76_10465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N76_10470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N76_10475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N76_10480	COG0089	rRNA binding
E4N76_10485	COG0088	Forms part of the polypeptide exit tunnel
E4N76_10490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N76_10495	COG0051	transcription antitermination factor activity, RNA binding
E4N76_10500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N76_10520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N76_10530	COG3706	GGDEF domain
E4N76_10550	COG0840	transmembrane signaling receptor activity
E4N76_10555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N76_10560	COG0564	pseudouridine synthase activity
E4N76_10570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N76_10575	COG0166	Belongs to the GPI family
E4N76_10580	COG1362	aminopeptidase activity
E4N76_10585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N76_10590	COG0724	RNA recognition motif
E4N76_10595	COG2211	Major facilitator Superfamily
E4N76_10645	COG1266	CAAX protease self-immunity
E4N76_10655	COG0396	ATPase activity
E4N76_10660	COG0719	Fe-S assembly protein
E4N76_10670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N76_10690	COG2201	protein-glutamate methylesterase activity
E4N76_10710	COG1137	ATPase activity
E4N76_10715	COG0193	aminoacyl-tRNA hydrolase activity
E4N76_10725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N76_10735	COG0601	transmembrane transport
E4N76_10740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_10745	COG0444	Belongs to the ABC transporter superfamily
E4N76_10750	COG4608	Belongs to the ABC transporter superfamily
E4N76_10755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N76_10760	COG1876	peptidase activity
E4N76_10780	COG0484	heat shock protein binding
E4N76_10785	COG0443	Heat shock 70 kDa protein
E4N76_10790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N76_10800	COG1120	ATPase activity
E4N76_10830	COG0534	Mate efflux family protein
E4N76_10855	COG1192	Involved in chromosome partitioning
E4N76_10860	COG1475	DNA binding
E4N76_10880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N76_10885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N76_10890	COG1028	Short-chain dehydrogenase reductase Sdr
E4N76_10905	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N76_10925	COG0439	Biotin carboxylase
E4N76_10930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N76_10935	COG0825	malonyl-CoA metabolic process
E4N76_10940	COG2986	histidine ammonia-lyase
E4N76_10955	COG0714	Associated with various cellular activities
E4N76_10995	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N76_11000	COG0154	amidase activity
E4N76_11005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N76_11060	COG3209	COG3209 Rhs family protein
E4N76_11170	COG1136	(ABC) transporter
E4N76_11305	COG1396	sequence-specific DNA binding
E4N76_11315	COG3550	peptidyl-serine autophosphorylation
E4N76_11350	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N76_11375	COG2226	methyltransferase
E4N76_11410	COG1132	(ABC) transporter
E4N76_11415	COG1132	(ABC) transporter
E4N76_11420	COG0280	phosphate acetyltransferase
E4N76_11425	COG0457	Tetratricopeptide repeat
E4N76_11430	COG0587	DNA-directed DNA polymerase activity
E4N76_11465	COG3177	Filamentation induced by cAMP protein fic
E4N76_11480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4N76_11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4N76_11485	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N76_11495	COG3448	diguanylate cyclase activity
E4N76_11495	COG4175	Glycine betaine
E4N76_11520	COG1136	(ABC) transporter
E4N76_11530	COG0095	Lipoate-protein ligase
E4N76_11540	COG1131	(ABC) transporter
E4N76_11545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N76_11550	COG1122	ATPase activity
E4N76_11595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N76_11610	COG0516	GMP reductase activity
E4N76_11615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N76_11620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N76_11650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N76_11680	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N76_11695	COG1774	PSP1 C-terminal conserved region
E4N76_11700	COG1728	Protein conserved in bacteria
E4N76_11710	COG0739	heme binding
E4N76_11730	COG0366	Alpha amylase catalytic
E4N76_11740	COG1609	Transcriptional regulator
E4N76_11745	COG1129	ABC transporter
E4N76_11775	COG0543	2 iron, 2 sulfur cluster binding
E4N76_11780	COG0784	Response regulator, receiver
E4N76_11780	COG3437	response regulator, receiver
E4N76_11800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N76_11840	COG3177	Filamentation induced by cAMP protein fic
E4N76_11855	COG1129	ABC transporter
E4N76_11860	COG1132	(ABC) transporter
E4N76_11890	COG1132	(ABC) transporter
E4N76_11895	COG1309	transcriptional regulator
E4N76_11900	COG3189	MarR family transcriptional regulator
E4N76_11915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N76_11920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N76_11925	COG1684	flagellar biosynthetic protein fliR
E4N76_11930	COG1987	bacterial-type flagellum assembly
E4N76_11955	COG1228	amidohydrolase
E4N76_11990	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N76_11995	COG0583	DNA-binding transcription factor activity
E4N76_12005	COG0747	negative chemotaxis
E4N76_12010	COG4608	Belongs to the ABC transporter superfamily
E4N76_12015	COG0444	Belongs to the ABC transporter superfamily
E4N76_12020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N76_12045	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N76_12060	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N76_12075	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N76_12085	COG4143	(ABC) transporter
E4N76_12090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4N76_12105	COG1473	amidohydrolase
E4N76_12110	COG4585	Histidine kinase
E4N76_12115	COG2197	response regulator
E4N76_12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N76_12150	COG0800	Aldolase
E4N76_12190	COG3093	addiction module antidote protein HigA
E4N76_12195	COG3549	Plasmid maintenance system killer
E4N76_12205	COG0728	peptidoglycan biosynthetic process
E4N76_12210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N76_12225	COG3588	fructose-bisphosphate aldolase
E4N76_12250	COG0012	GTP binding
E4N76_12255	COG0616	signal peptide processing
E4N76_12260	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4N76_12280	COG5012	cobalamin binding
E4N76_12285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N76_12290	COG1132	(ABC) transporter
E4N76_12295	COG1132	(ABC) transporter
E4N76_12305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N76_12310	COG0363	glucosamine-6-phosphate deaminase activity
E4N76_12320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N76_12325	COG0534	Mate efflux family protein
E4N76_12330	COG1309	transcriptional regulator
E4N76_12335	COG0786	glutamate:sodium symporter activity
E4N76_12340	COG0840	transmembrane signaling receptor activity
E4N76_12345	COG0840	transmembrane signaling receptor activity
E4N76_12350	COG0813	purine-nucleoside phosphorylase activity
E4N76_12395	COG5002	protein histidine kinase activity
E4N76_12395	COG5001	Diguanylate cyclase
E4N76_12400	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N76_12400	COG0540	Belongs to the ATCase OTCase family
E4N76_12430	COG3118	belongs to the thioredoxin family
E4N76_12435	COG3842	ATPase activity
E4N76_12440	COG3833	ABC-type maltose transport systems, permease component
E4N76_12445	COG1175	transmembrane transport
E4N76_12455	COG1418	mRNA catabolic process
E4N76_12460	COG0419	ATPase involved in DNA repair
E4N76_12465	COG0420	3'-5' exonuclease activity
E4N76_12470	COG3290	protein histidine kinase activity
E4N76_12470	COG0840	transmembrane signaling receptor activity
E4N76_12480	COG1131	(ABC) transporter
E4N76_12500	COG0716	FMN binding
E4N76_12515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N76_12520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N76_12525	COG0592	DNA-directed DNA polymerase activity
E4N76_12530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N76_12610	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4N76_12665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N76_12680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N76_12690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N76_12725	COG2184	nucleotidyltransferase activity
E4N76_12735	COG0730	response to heat
E4N76_12755	COG4208	sulfate ABC transporter
E4N76_12760	COG3839	Belongs to the ABC transporter superfamily
E4N76_12770	COG0840	transmembrane signaling receptor activity
E4N76_12785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N76_12790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N76_12795	COG1674	ftsk spoiiie
E4N76_12800	COG1968	undecaprenyl-diphosphatase activity
E4N76_12810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N76_12835	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N76_12840	COG0534	Mate efflux family protein
E4N76_12845	COG0569	domain protein
E4N76_12850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N76_12870	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N76_12875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N76_12900	COG2235	arginine
E4N76_12905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N76_12915	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N76_12920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N76_12925	COG0569	domain protein
E4N76_12935	COG1487	ribonuclease activity
E4N76_12950	COG0714	Associated with various cellular activities
E4N76_12955	COG4536	flavin adenine dinucleotide binding
E4N76_12960	COG4536	flavin adenine dinucleotide binding
E4N76_12975	COG0514	ATP-dependent DNA helicase (RecQ)
E4N76_12985	COG1518	maintenance of DNA repeat elements
E4N76_12990	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N76_13005	COG1132	(ABC) transporter
E4N76_13025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N76_13035	COG3271	cysteine-type peptidase activity
E4N76_13035	COG2274	protein secretion by the type I secretion system
E4N76_13045	COG0438	transferase activity, transferring glycosyl groups
E4N76_13050	COG3842	ATPase activity
E4N76_13075	COG3706	GGDEF domain
E4N76_13085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N76_13090	COG0215	cysteine-tRNA ligase activity
E4N76_13105	COG1305	Transglutaminase-like
E4N76_13110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N76_13115	COG0569	domain protein
E4N76_13120	COG2887	Belongs to the helicase family. UvrD subfamily
E4N76_13125	COG1074	ATP-dependent DNA helicase activity
E4N76_13180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N76_13230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N76_13240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N76_13250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N76_13260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N76_13270	COG4555	ABC transporter
E4N76_13285	COG0840	transmembrane signaling receptor activity
E4N76_13315	COG1151	hydroxylamine reductase activity
E4N76_13335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N76_13340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N76_13360	COG1401	restriction endodeoxyribonuclease activity
E4N76_13375	COG0823	Involved in the tonB-independent uptake of proteins
E4N76_13375	COG4946	Tricorn protease homolog
E4N76_13375	COG1506	peptidase
E4N76_13390	COG1104	cysteine desulfurase activity
E4N76_13395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N76_13400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N76_13420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N76_13435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N76_13445	COG1929	Belongs to the glycerate kinase type-1 family
E4N76_13450	COG2217	Heavy metal translocating P-type atpase
E4N76_13460	COG0494	nUDIX hydrolase
E4N76_13465	COG0783	Belongs to the Dps family
E4N76_13470	COG0450	alkyl hydroperoxide reductase
E4N76_13475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N76_13490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N76_13495	COG1363	Peptidase, m42
E4N76_13505	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N76_13510	COG0423	glycine-tRNA ligase activity
E4N76_13530	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N76_13635	COG1129	ABC transporter
E4N76_13650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N76_13685	COG1132	(ABC) transporter
E4N76_13690	COG2375	cellular response to nickel ion
E4N76_13690	COG1132	(ABC) transporter
E4N76_13720	COG0456	acetyltransferase
E4N76_13755	COG1129	ABC transporter
E4N76_13825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N76_13860	COG1191	sigma factor activity
E4N76_13875	COG1419	protein localization to endoplasmic reticulum
E4N76_13880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N76_13900	COG1132	(ABC) transporter
E4N76_13915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N76_13930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N76_13935	COG1360	Flagellar Motor Protein
E4N76_13940	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N76_13945	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N76_13950	COG1776	CheC inhibitor of MCP methylation
E4N76_13950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N76_13960	COG1338	Plays a role in the flagellum-specific transport system
E4N76_13990	COG4166	transmembrane transport
E4N76_13995	COG2423	ornithine cyclodeaminase activity
E4N76_14000	COG0739	heme binding
E4N76_14000	COG0741	lytic transglycosylase activity
E4N76_14000	COG1196	nuclear chromosome segregation
E4N76_14005	COG4545	Glutaredoxin-related protein
E4N76_14020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N76_14035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N76_14035	COG3116	cell division
E4N76_14040	COG0084	hydrolase, TatD family'
E4N76_14050	COG2203	Gaf domain
E4N76_14050	COG2199	diguanylate cyclase activity
E4N76_14080	COG0187	DNA topoisomerase II activity