locus-tag	class	description
DYE49_00010	COG3437	response regulator, receiver
DYE49_00015	COG4487	mechanosensitive ion channel activity
DYE49_00025	COG3706	GGDEF domain
DYE49_00130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DYE49_00135	COG4869	propanediol catabolic process
DYE49_00150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DYE49_00155	COG1982	Orn Lys Arg decarboxylase major
DYE49_00165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DYE49_00190	COG0494	nUDIX hydrolase
DYE49_00210	COG1175	transmembrane transport
DYE49_00215	COG3833	ABC-type maltose transport systems, permease component
DYE49_00225	COG3842	ATPase activity
DYE49_00250	COG0475	glutathione-regulated potassium exporter activity
DYE49_00275	COG0039	L-malate dehydrogenase activity
DYE49_00285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DYE49_00285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DYE49_00290	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DYE49_00295	COG4770	biotin carboxylase activity
DYE49_00335	COG1362	aminopeptidase activity
DYE49_00340	COG0280	phosphate acetyltransferase
DYE49_00350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DYE49_00370	COG2203	Gaf domain
DYE49_00370	COG3706	GGDEF domain
DYE49_00370	COG4251	negative regulation of phosphorylation
DYE49_00370	COG5001	Diguanylate cyclase
DYE49_00385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DYE49_00410	COG3279	Response regulator of the LytR AlgR family
DYE49_00430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DYE49_00435	COG0562	UDP-galactopyranose mutase
DYE49_00450	COG1132	(ABC) transporter
DYE49_00455	COG1132	(ABC) transporter
DYE49_00460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DYE49_00475	COG0463	Glycosyl transferase, family 2
DYE49_00480	COG0492	ferredoxin-NADP+ reductase activity
DYE49_00500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DYE49_00530	COG0252	asparaginase activity
DYE49_00540	COG0318	PFAM AMP-dependent synthetase and ligase
DYE49_00555	COG2208	phosphoserine phosphatase activity
DYE49_00585	COG2204	response regulator
DYE49_00595	COG2801	Transposase and inactivated derivatives
DYE49_00695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DYE49_00715	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DYE49_00720	COG0406	alpha-ribazole phosphatase activity
DYE49_00725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DYE49_00730	COG1523	belongs to the glycosyl hydrolase 13 family
DYE49_00735	COG3250	beta-galactosidase activity
DYE49_00745	COG1126	abc transporter atp-binding protein
DYE49_00750	COG0765	amino acid transport
DYE49_00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DYE49_00770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DYE49_00775	COG1846	Transcriptional regulator
DYE49_00780	COG0386	Belongs to the glutathione peroxidase family
DYE49_00795	COG0564	pseudouridine synthase activity
DYE49_00805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DYE49_00825	COG0579	oxidoreductase
DYE49_00850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DYE49_00855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DYE49_00870	COG1028	Short-chain dehydrogenase reductase Sdr
DYE49_00880	COG1132	(ABC) transporter
DYE49_00885	COG1132	(ABC) transporter
DYE49_00890	COG0779	Required for maturation of 30S ribosomal subunits
DYE49_00895	COG0195	Participates in both transcription termination and antitermination
DYE49_00910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DYE49_00915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DYE49_00920	COG0196	riboflavin kinase activity
DYE49_00925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DYE49_00930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DYE49_00935	COG2081	HI0933 family
DYE49_00990	COG0668	transmembrane transport
DYE49_01000	COG0662	Cupin 2, conserved barrel domain protein
DYE49_01000	COG2207	Transcriptional regulator
DYE49_01025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DYE49_01070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DYE49_01075	COG0825	malonyl-CoA metabolic process
DYE49_01080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DYE49_01085	COG0439	Biotin carboxylase
DYE49_01090	COG0511	ligase activity, forming carbon-carbon bonds
DYE49_01095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DYE49_01105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DYE49_01110	COG1028	Short-chain dehydrogenase reductase Sdr
DYE49_01115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DYE49_01120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DYE49_01160	COG1285	pathogenesis
DYE49_01165	COG0366	Alpha amylase catalytic
DYE49_01170	COG0745	RESPONSE REGULATOR receiver
DYE49_01175	COG5002	protein histidine kinase activity
DYE49_01180	COG0517	IMP dehydrogenase activity
DYE49_01180	COG0516	GMP reductase activity
DYE49_01185	COG1970	mechanosensitive ion channel activity
DYE49_01250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DYE49_01260	COG0058	SHG alpha-glucan phosphorylase activity
DYE49_01270	COG0544	peptidyl-prolyl cis-trans isomerase activity
DYE49_01275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DYE49_01280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DYE49_01295	COG2003	Belongs to the UPF0758 family
DYE49_01325	COG1461	Dihydroxyacetone kinase
DYE49_01340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DYE49_01355	COG0552	protein localization to endoplasmic reticulum
DYE49_01365	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DYE49_01370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DYE49_01395	COG0228	four-way junction DNA binding
DYE49_01400	COG0335	large ribosomal subunit rRNA binding
DYE49_01405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DYE49_01415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DYE49_01420	COG0222	ribosome binding
DYE49_01425	COG0085	RNA polymerase activity
DYE49_01430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DYE49_01460	COG1373	ATPase (AAA superfamily
DYE49_01465	COG3706	GGDEF domain
DYE49_01470	COG2272	Belongs to the type-B carboxylesterase lipase family
DYE49_01485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DYE49_01520	COG1132	(ABC) transporter
DYE49_01525	COG1132	(ABC) transporter
DYE49_01540	COG0426	domain, Protein
DYE49_01545	COG0326	Molecular chaperone. Has ATPase activity
DYE49_01565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DYE49_01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DYE49_01595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DYE49_01600	COG1328	CTP reductase activity
DYE49_01600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DYE49_01605	COG0602	queuosine metabolic process
DYE49_01665	COG1131	(ABC) transporter
DYE49_01675	COG2184	nucleotidyltransferase activity
DYE49_01680	COG0110	maltose O-acetyltransferase activity
DYE49_01725	COG2199	diguanylate cyclase activity
DYE49_01725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DYE49_01760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DYE49_01765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DYE49_01770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DYE49_01775	COG0436	Aminotransferase
DYE49_01780	COG0019	diaminopimelate decarboxylase activity
DYE49_01785	COG0460	homoserine dehydrogenase
DYE49_01785	COG0527	aspartate kinase activity
DYE49_01795	COG1442	glycosyl transferase family 8
DYE49_01800	COG1131	(ABC) transporter
DYE49_01820	COG0052	Belongs to the universal ribosomal protein uS2 family
DYE49_01825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DYE49_01830	COG0528	UMP kinase activity
DYE49_01845	COG4589	Belongs to the CDS family
DYE49_01850	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DYE49_01855	COG0750	zinc metalloprotease
DYE49_01860	COG2176	DNA-directed DNA polymerase activity
DYE49_01875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DYE49_01885	COG0017	Asparaginyl-tRNA synthetase
DYE49_01890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DYE49_01920	COG3481	metal-dependent phosphohydrolase, HD sub domain
DYE49_01935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DYE49_01940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DYE49_01945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DYE49_01950	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DYE49_01955	COG1674	ftsk spoiiie
DYE49_01970	COG1523	belongs to the glycosyl hydrolase 13 family
DYE49_01980	COG0318	PFAM AMP-dependent synthetase and ligase
DYE49_01980	COG0204	Acyl-transferase
DYE49_02000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DYE49_02010	COG0297	glycogen (starch) synthase activity
DYE49_02035	COG0631	protein serine/threonine phosphatase activity
DYE49_02040	COG2815	serine threonine protein kinase
DYE49_02040	COG0515	serine threonine protein kinase
DYE49_02045	COG1162	GTPase activity
DYE49_02060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DYE49_02070	COG1454	alcohol dehydrogenase
DYE49_02070	COG1012	belongs to the aldehyde dehydrogenase family
DYE49_02095	COG4536	flavin adenine dinucleotide binding
DYE49_02100	COG1253	flavin adenine dinucleotide binding
DYE49_02110	COG2365	Tyrosine phosphatase family
DYE49_02125	COG0484	heat shock protein binding
DYE49_02140	COG1420	regulation of RNA biosynthetic process
DYE49_02145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DYE49_02150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DYE49_02155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DYE49_02180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DYE49_02255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DYE49_02275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DYE49_02325	COG1091	dTDP-4-dehydrorhamnose reductase activity
DYE49_02345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DYE49_02355	COG0438	transferase activity, transferring glycosyl groups
DYE49_02360	COG0438	transferase activity, transferring glycosyl groups
DYE49_02365	COG0535	radical SAM domain protein
DYE49_02415	COG1213	nucleotidyl transferase
DYE49_02420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DYE49_02550	COG1373	ATPase (AAA superfamily
DYE49_02560	COG1373	ATPase (AAA superfamily
DYE49_02750	COG1078	dGTPase activity
DYE49_02760	COG0803	Belongs to the bacterial solute-binding protein 9 family
DYE49_02760	COG3443	Belongs to the bacterial solute-binding protein 9 family
DYE49_02765	COG1121	(ABC) transporter
DYE49_02770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DYE49_02785	COG1268	BioY protein
DYE49_02800	COG1045	serine acetyltransferase
DYE49_02805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DYE49_02830	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DYE49_02845	COG0359	binds to the 23S rRNA
DYE49_02850	COG0305	Participates in initiation and elongation during chromosome replication
DYE49_02855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DYE49_02875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DYE49_02885	COG0154	amidase activity
DYE49_02890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DYE49_02900	COG0343	queuine tRNA-ribosyltransferase activity
DYE49_02905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DYE49_02920	COG1192	Involved in chromosome partitioning
DYE49_02935	COG0537	adenosine 5'-monophosphoramidase activity
DYE49_02940	COG0396	ATPase activity
DYE49_02945	COG0719	Fe-S assembly protein
DYE49_02950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DYE49_02960	COG0719	Fe-S assembly protein
DYE49_02965	COG0445	tRNA wobble uridine modification
DYE49_02985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DYE49_02985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DYE49_02990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DYE49_03000	COG1309	transcriptional regulator
DYE49_03020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DYE49_03025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DYE49_03030	COG1490	D-aminoacyl-tRNA deacylase activity
DYE49_03035	COG0482	sulfurtransferase activity
DYE49_03040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DYE49_03045	COG1760	l-serine dehydratase
DYE49_03080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DYE49_03135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DYE49_03145	COG0268	Binds directly to 16S ribosomal RNA
DYE49_03160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DYE49_03165	COG0708	Exodeoxyribonuclease III
DYE49_03175	COG2957	Belongs to the agmatine deiminase family
DYE49_03205	COG0366	Alpha amylase catalytic
DYE49_03210	COG0656	L-ascorbic acid biosynthetic process
DYE49_03215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DYE49_03220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DYE49_03235	COG5001	Diguanylate cyclase
DYE49_03235	COG3300	MHYT domain
DYE49_03255	COG3279	Response regulator of the LytR AlgR family
DYE49_03270	COG1472	Belongs to the glycosyl hydrolase 3 family
DYE49_03285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DYE49_03325	COG3279	Response regulator of the LytR AlgR family
DYE49_03340	COG0071	Belongs to the small heat shock protein (HSP20) family
DYE49_03345	COG1472	Belongs to the glycosyl hydrolase 3 family
DYE49_03355	COG0668	transmembrane transport
DYE49_03360	COG2770	Histidine kinase
DYE49_03360	COG3437	response regulator, receiver
DYE49_03370	COG2199	diguanylate cyclase activity
DYE49_03425	COG5002	protein histidine kinase activity
DYE49_03440	COG1773	rubredoxin
DYE49_03455	COG1307	EDD domain protein, DegV family
DYE49_03465	COG0051	transcription antitermination factor activity, RNA binding
DYE49_03470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DYE49_03475	COG0088	Forms part of the polypeptide exit tunnel
DYE49_03480	COG0089	rRNA binding
DYE49_03490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DYE49_03495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DYE49_03500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DYE49_03505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DYE49_03510	COG0255	Belongs to the universal ribosomal protein uL29 family
DYE49_03515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DYE49_03520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DYE49_03525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DYE49_03530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DYE49_03545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DYE49_03555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DYE49_03560	COG0200	Binds to the 23S rRNA
DYE49_03570	COG0563	adenylate kinase activity
DYE49_03585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DYE49_03590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DYE49_03595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DYE49_03600	COG0202	RNA polymerase activity
DYE49_03605	COG0203	ribosomal protein L17
DYE49_03610	COG2184	nucleotidyltransferase activity
DYE49_03635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DYE49_03640	COG1160	GTP binding
DYE49_03645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DYE49_03650	COG0776	regulation of translation
DYE49_03655	COG0617	tRNA 3'-terminal CCA addition
DYE49_03665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DYE49_03695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DYE49_03705	COG0481	GTPase activity
DYE49_03780	COG0534	Mate efflux family protein
DYE49_03785	COG2199	diguanylate cyclase activity
DYE49_03785	COG2203	Gaf domain
DYE49_03790	COG1307	EDD domain protein, DegV family
DYE49_03825	COG0494	nUDIX hydrolase
DYE49_03835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DYE49_03835	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DYE49_03910	COG0505	Belongs to the CarA family
DYE49_03915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DYE49_03920	COG0543	2 iron, 2 sulfur cluster binding
DYE49_03925	COG0167	dihydroorotate dehydrogenase activity
DYE49_03930	COG0284	orotidine-5'-phosphate decarboxylase activity
DYE49_03935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DYE49_03960	COG0656	L-ascorbic acid biosynthetic process
DYE49_04005	COG0714	Associated with various cellular activities
DYE49_04020	COG2304	oxidoreductase activity
DYE49_04045	COG1177	transmembrane transport
DYE49_04055	COG3839	Belongs to the ABC transporter superfamily
DYE49_04060	COG2199	diguanylate cyclase activity
DYE49_04060	COG2203	Gaf domain
DYE49_04085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DYE49_04095	COG0495	leucyl-tRNA aminoacylation
DYE49_04100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DYE49_04140	COG1131	(ABC) transporter
DYE49_04165	COG3579	cysteine-type endopeptidase activity
DYE49_04175	COG0037	tRNA processing
DYE49_04200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DYE49_04205	COG1570	exodeoxyribonuclease VII activity
DYE49_04215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DYE49_04220	COG0497	DNA recombination
DYE49_04230	COG4974	Belongs to the 'phage' integrase family
DYE49_04255	COG3279	Response regulator of the LytR AlgR family
DYE49_04275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DYE49_04285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DYE49_04290	COG0187	DNA topoisomerase II activity
DYE49_04295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DYE49_04300	COG3763	UPF0154 protein
DYE49_04305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DYE49_04310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DYE49_04330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DYE49_04335	COG0124	histidyl-tRNA synthetase
DYE49_04340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DYE49_04345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DYE49_04365	COG2384	SAM-dependent methyltransferase
DYE49_04375	COG0358	DNA primase activity
DYE49_04395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DYE49_04425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DYE49_04450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DYE49_04455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DYE49_04475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DYE49_04475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DYE49_04480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DYE49_04485	COG2255	four-way junction helicase activity
DYE49_04500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DYE49_04505	COG2868	ribosomal protein
DYE49_04570	COG0124	histidyl-tRNA synthetase
DYE49_04580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DYE49_04585	COG2089	acid synthase
DYE49_04605	COG0217	transcriptional regulatory protein
DYE49_04610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DYE49_04615	COG0632	four-way junction helicase activity
DYE49_04620	COG2255	four-way junction helicase activity
DYE49_04625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DYE49_04645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DYE49_04650	COG1086	Polysaccharide biosynthesis protein
DYE49_04670	COG2986	histidine ammonia-lyase
DYE49_04675	COG0670	Belongs to the BI1 family
DYE49_04685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DYE49_04700	COG0628	permease
DYE49_04705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DYE49_04725	COG1196	nuclear chromosome segregation
DYE49_04735	COG0297	glycogen (starch) synthase activity
DYE49_04740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DYE49_04745	COG0740	serine-type endopeptidase activity
DYE49_04750	COG0544	peptidyl-prolyl cis-trans isomerase activity
DYE49_04795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DYE49_04800	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DYE49_04810	COG1214	PFAM Peptidase M22, glycoprotease
DYE49_04815	COG0802	atpase or kinase
DYE49_04855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DYE49_04875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DYE49_04890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DYE49_04900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DYE49_04905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DYE49_04910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DYE49_04930	COG0210	DNA helicase
DYE49_04935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DYE49_04955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DYE49_04960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DYE49_04970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DYE49_04970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DYE49_04985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DYE49_04990	COG5002	protein histidine kinase activity
DYE49_04995	COG0745	RESPONSE REGULATOR receiver
DYE49_05005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DYE49_05010	COG1360	Flagellar Motor Protein
DYE49_05015	COG1580	Controls the rotational direction of flagella during chemotaxis
DYE49_05020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DYE49_05035	COG1338	Plays a role in the flagellum-specific transport system
DYE49_05040	COG1987	bacterial-type flagellum assembly
DYE49_05045	COG1684	flagellar biosynthetic protein fliR
DYE49_05050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DYE49_05060	COG1419	protein localization to endoplasmic reticulum
DYE49_05075	COG1191	sigma factor activity
DYE49_05100	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
DYE49_05110	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DYE49_05115	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DYE49_05120	COG1394	ATPase activity, coupled to movement of substances
DYE49_05125	COG1269	ATP hydrolysis coupled proton transport
DYE49_05135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DYE49_05160	COG0438	transferase activity, transferring glycosyl groups
DYE49_05185	COG1213	nucleotidyl transferase
DYE49_05195	COG0706	membrane insertase activity
DYE49_05210	COG0840	transmembrane signaling receptor activity
DYE49_05220	COG0463	Glycosyl transferase, family 2
DYE49_05250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DYE49_05265	COG0297	glycogen (starch) synthase activity
DYE49_05275	COG1216	Glycosyl transferase, family 2
DYE49_05275	COG1442	glycosyl transferase family 8
DYE49_05355	COG1136	(ABC) transporter
DYE49_05360	COG0562	UDP-galactopyranose mutase
DYE49_05390	COG4977	sequence-specific DNA binding
DYE49_05400	COG0235	Class ii aldolase
DYE49_05415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DYE49_05420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DYE49_05430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DYE49_05445	COG0742	ribosomal rna small subunit methyltransferase
DYE49_05455	COG0360	Binds together with S18 to 16S ribosomal RNA
DYE49_05460	COG0629	single-stranded DNA binding
DYE49_05465	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DYE49_05470	COG0359	binds to the 23S rRNA
DYE49_05475	COG0305	Participates in initiation and elongation during chromosome replication
DYE49_05490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DYE49_05495	COG2267	carboxylic ester hydrolase activity
DYE49_05500	COG0617	tRNA 3'-terminal CCA addition
DYE49_05510	COG0564	pseudouridine synthase activity
DYE49_05550	COG1449	Belongs to the glycosyl hydrolase 57 family
DYE49_05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DYE49_05560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DYE49_05575	COG0436	Aminotransferase
DYE49_05580	COG0297	glycogen (starch) synthase activity
DYE49_05590	COG0750	zinc metalloprotease
DYE49_05595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DYE49_05600	COG4589	Belongs to the CDS family
DYE49_05605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DYE49_05610	COG0233	cytoplasmic translational termination
DYE49_05615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DYE49_05620	COG0052	Belongs to the universal ribosomal protein uS2 family
DYE49_05625	COG0424	maF-like protein
DYE49_05635	COG1413	lyase activity
DYE49_05645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DYE49_05650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DYE49_05660	COG0571	ribonuclease III activity
DYE49_05675	COG1309	transcriptional regulator
DYE49_05700	COG1091	dTDP-4-dehydrorhamnose reductase activity
DYE49_05705	COG1234	tRNA 3'-trailer cleavage
DYE49_05710	COG1131	(ABC) transporter
DYE49_05725	COG0285	dihydrofolate synthase activity
DYE49_05730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DYE49_05735	COG0180	Tryptophanyl-tRNA synthetase
DYE49_05740	COG0617	tRNA 3'-terminal CCA addition
DYE49_05780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DYE49_05785	COG0358	DNA primase activity
DYE49_05790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DYE49_05810	COG1077	Cell shape determining protein MreB Mrl
DYE49_05825	COG0768	penicillin binding
DYE49_05830	COG0772	Belongs to the SEDS family
DYE49_05840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DYE49_05955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DYE49_05975	COG1683	Conserved Protein
DYE49_06010	COG3386	PFAM SMP-30 Gluconolaconase
DYE49_06025	COG3706	GGDEF domain
DYE49_06055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DYE49_06075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DYE49_06080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DYE49_06105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DYE49_06120	COG0019	diaminopimelate decarboxylase activity
DYE49_06130	COG3254	rhamnose metabolic process
DYE49_06135	COG4806	L-rhamnose isomerase
DYE49_06140	COG1102	Psort location Cytoplasmic, score
DYE49_06150	COG1561	YicC-like family, N-terminal region
DYE49_06200	COG4786	Flagellar basal body rod
DYE49_06205	COG5001	Diguanylate cyclase
DYE49_06205	COG3300	MHYT domain
DYE49_06210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DYE49_06215	COG0484	heat shock protein binding
DYE49_06220	COG2204	response regulator
DYE49_06225	COG3852	Histidine kinase
DYE49_06240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DYE49_06245	COG0148	phosphopyruvate hydratase activity
DYE49_06265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DYE49_06290	COG0301	tRNA thio-modification
DYE49_06315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DYE49_06330	COG0736	holo-[acyl-carrier-protein] synthase activity
DYE49_06345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DYE49_06350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DYE49_06355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DYE49_06370	COG1366	Belongs to the anti-sigma-factor antagonist family
DYE49_06380	COG2208	phosphoserine phosphatase activity
DYE49_06380	COG2770	Histidine kinase
DYE49_06385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DYE49_06395	COG0009	L-threonylcarbamoyladenylate synthase
DYE49_06430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DYE49_06440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DYE49_06450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DYE49_06455	COG1459	type II secretion system
DYE49_06520	COG0488	(ABC) transporter
DYE49_06540	COG0254	rRNA binding
DYE49_06545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DYE49_06575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DYE49_06580	COG0719	Fe-S assembly protein
DYE49_06590	COG0396	ATPase activity
DYE49_06600	COG0776	regulation of translation
DYE49_06605	COG0268	Binds directly to 16S ribosomal RNA
DYE49_06620	COG1199	ATP-dependent helicase activity
DYE49_06625	COG0039	L-malate dehydrogenase activity
DYE49_06645	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DYE49_06675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DYE49_06680	COG0490	domain, Protein
DYE49_06680	COG2985	domain, Protein
DYE49_06715	COG1388	LysM domain
DYE49_06715	COG0860	N-Acetylmuramoyl-L-alanine amidase
DYE49_06725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DYE49_06735	COG0731	radical SAM domain protein
DYE49_06740	COG1570	exodeoxyribonuclease VII activity
DYE49_06745	COG1722	exodeoxyribonuclease VII activity
DYE49_06750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DYE49_06800	COG1543	Belongs to the glycosyl hydrolase 57 family
DYE49_06830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DYE49_06860	COG0653	protein targeting
DYE49_06875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DYE49_06890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DYE49_06895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DYE49_06915	COG3604	Transcriptional regulator
DYE49_06920	COG0539	negative regulation of cytoplasmic translation
DYE49_06930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DYE49_06935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DYE49_06940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DYE49_06945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DYE49_06965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DYE49_06975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DYE49_06975	COG1747	RNA polymerase binding
DYE49_06985	COG0708	Exodeoxyribonuclease III
DYE49_07000	COG0739	heme binding
DYE49_07015	COG1475	DNA binding
DYE49_07020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DYE49_07025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DYE49_07025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DYE49_07030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DYE49_07050	COG1032	radical SAM domain protein
DYE49_07055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DYE49_07060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DYE49_07070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DYE49_07075	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DYE49_07080	COG2201	protein-glutamate methylesterase activity
DYE49_07090	COG0835	chemotaxis
DYE49_07095	COG2198	Histidine kinase
DYE49_07095	COG0643	Histidine kinase
DYE49_07105	COG0436	Aminotransferase
DYE49_07115	COG0745	RESPONSE REGULATOR receiver
DYE49_07125	COG1394	ATPase activity, coupled to movement of substances
DYE49_07130	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DYE49_07135	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DYE49_07155	COG1269	ATP hydrolysis coupled proton transport
DYE49_07175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DYE49_07180	COG0149	triose-phosphate isomerase activity
DYE49_07190	COG4115	mRNA cleavage
DYE49_07200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DYE49_07215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DYE49_07250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DYE49_07255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DYE49_07260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DYE49_07270	COG1162	GTPase activity
DYE49_07285	COG2201	protein-glutamate methylesterase activity
DYE49_07295	COG0643	Histidine kinase
DYE49_07295	COG0784	Response regulator, receiver
DYE49_07295	COG2198	Histidine kinase
DYE49_07345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DYE49_07350	COG2203	Gaf domain
DYE49_07350	COG3706	GGDEF domain
DYE49_07350	COG4251	negative regulation of phosphorylation
DYE49_07350	COG5001	Diguanylate cyclase
DYE49_07355	COG3706	GGDEF domain
DYE49_07355	COG2203	Gaf domain
DYE49_07355	COG4251	negative regulation of phosphorylation
DYE49_07355	COG5001	Diguanylate cyclase
DYE49_07365	COG1739	Uncharacterized protein family UPF0029
DYE49_07395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DYE49_07400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DYE49_07405	COG4974	Belongs to the 'phage' integrase family
DYE49_07410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DYE49_07410	COG0551	DNA topoisomerase type I activity
DYE49_07415	COG0758	DNA mediated transformation
DYE49_07415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DYE49_07425	COG4974	Belongs to the 'phage' integrase family
DYE49_07440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DYE49_07445	COG0772	Belongs to the SEDS family
DYE49_07450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DYE49_07460	COG0275	rRNA processing
DYE49_07465	COG2001	Belongs to the MraZ family
DYE49_07485	COG0191	fructose-bisphosphate aldolase activity
DYE49_07505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DYE49_07520	COG1671	Belongs to the UPF0178 family
DYE49_07535	COG0542	response to heat
DYE49_07555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DYE49_07560	COG0659	secondary active sulfate transmembrane transporter activity
DYE49_07600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DYE49_07670	COG0497	DNA recombination
DYE49_07675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DYE49_07685	COG0835	chemotaxis
DYE49_07700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DYE49_07710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DYE49_07720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DYE49_07730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DYE49_07735	COG1104	cysteine desulfurase activity
DYE49_07745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DYE49_07760	COG0542	response to heat
DYE49_07765	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DYE49_07780	COG1136	(ABC) transporter
DYE49_07785	COG4591	ABC-type transport system involved in lipoprotein release permease component
DYE49_07795	COG0552	protein localization to endoplasmic reticulum
DYE49_07805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DYE49_07830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DYE49_07835	COG1480	7TM receptor with intracellular HD hydrolase
DYE49_07840	COG1702	phosphate starvation-inducible protein PhoH
DYE49_07850	COG2604	Protein of unknown function DUF115
DYE49_07870	COG0481	GTPase activity
DYE49_07875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DYE49_07880	COG0457	Tetratricopeptide repeat
DYE49_07885	COG0037	tRNA processing
DYE49_07890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DYE49_07900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DYE49_07910	COG0799	negative regulation of ribosome biogenesis
DYE49_07930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DYE49_07945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DYE49_07950	COG0126	phosphoglycerate kinase activity
DYE49_07955	COG0456	acetyltransferase
DYE49_07960	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DYE49_07990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DYE49_08005	COG0440	acetolactate synthase activity
DYE49_08010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DYE49_08025	COG1454	alcohol dehydrogenase
DYE49_08030	COG0803	Belongs to the bacterial solute-binding protein 9 family
DYE49_08040	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DYE49_08045	COG2502	aspartate--ammonia ligase
DYE49_08055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DYE49_08065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DYE49_08095	COG0811	peptide transport
DYE49_08125	COG0557	exoribonuclease II activity
DYE49_08130	COG0527	aspartate kinase activity
DYE49_08130	COG0460	homoserine dehydrogenase
DYE49_08135	COG0010	Belongs to the arginase family
DYE49_08150	COG2202	Pas domain
DYE49_08150	COG2199	diguanylate cyclase activity
DYE49_08150	COG2200	EAL domain
DYE49_08175	COG0343	queuine tRNA-ribosyltransferase activity
DYE49_08190	COG0756	dUTP diphosphatase activity
DYE49_08195	COG0612	Peptidase, M16
DYE49_08200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DYE49_08215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DYE49_08220	COG2890	protein-(glutamine-N5) methyltransferase activity
DYE49_08225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DYE49_08230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DYE49_08235	COG0826	peptidase U32
DYE49_08245	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DYE49_08265	COG0534	Mate efflux family protein
DYE49_08270	COG0495	leucyl-tRNA aminoacylation
DYE49_08275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DYE49_08320	COG0395	ABC-type sugar transport system, permease component
DYE49_08325	COG4209	transmembrane transport
DYE49_08335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DYE49_08350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DYE49_08360	COG0205	6-phosphofructokinase activity
DYE49_08395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DYE49_08405	COG1373	ATPase (AAA superfamily
DYE49_08440	COG5001	Diguanylate cyclase
DYE49_08450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DYE49_08480	COG2731	YhcH YjgK YiaL family protein
DYE49_08485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DYE49_08490	COG1028	Short-chain dehydrogenase reductase Sdr
DYE49_08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DYE49_08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DYE49_08565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DYE49_08570	COG1469	GTP cyclohydrolase I activity
DYE49_08575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DYE49_08590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DYE49_08595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DYE49_08625	COG0280	phosphate acetyltransferase
DYE49_08630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DYE49_08655	COG0228	four-way junction DNA binding
DYE49_08660	COG1837	Belongs to the UPF0109 family
DYE49_08665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DYE49_08670	COG0336	Belongs to the RNA methyltransferase TrmD family
DYE49_08675	COG0335	large ribosomal subunit rRNA binding
DYE49_08685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DYE49_08695	COG0792	nuclease activity
DYE49_08725	COG0840	transmembrane signaling receptor activity
DYE49_08730	COG0840	transmembrane signaling receptor activity
DYE49_08740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DYE49_08750	COG0488	(ABC) transporter
DYE49_08770	COG0737	Belongs to the 5'-nucleotidase family
DYE49_08770	COG4085	toxin activity
DYE49_08770	COG1525	nuclease
DYE49_08810	COG2003	Belongs to the UPF0758 family
DYE49_08830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DYE49_08835	COG0165	Argininosuccinate lyase
DYE49_08845	COG0028	Belongs to the TPP enzyme family
DYE49_08850	COG2199	diguanylate cyclase activity
DYE49_08850	COG2203	Gaf domain
DYE49_08865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DYE49_08890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DYE49_08905	COG1187	pseudouridine synthase activity
DYE49_08910	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DYE49_08930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DYE49_08945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DYE49_08955	COG1157	protein secretion by the type III secretion system
DYE49_08960	COG1317	bacterial-type flagellum organization
DYE49_08970	COG1766	The M ring may be actively involved in energy transduction
DYE49_08990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DYE49_09000	COG0484	heat shock protein binding
DYE49_09015	COG1366	Belongs to the anti-sigma-factor antagonist family
DYE49_09020	COG1876	peptidase activity
DYE49_09025	COG0372	Belongs to the citrate synthase family
DYE49_09035	COG3459	Glycosyltransferase 36 associated
DYE49_09045	COG1472	Belongs to the glycosyl hydrolase 3 family
DYE49_09060	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DYE49_09060	COG2755	lipolytic protein G-D-S-L family
DYE49_09065	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DYE49_09070	COG1472	Belongs to the glycosyl hydrolase 3 family
DYE49_09080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DYE49_09090	COG2608	mercury ion transmembrane transporter activity
DYE49_09105	COG2801	Transposase and inactivated derivatives
DYE49_09120	COG4585	Histidine kinase
DYE49_09125	COG0745	RESPONSE REGULATOR receiver
DYE49_09140	COG3833	ABC-type maltose transport systems, permease component
DYE49_09145	COG1175	transmembrane transport
DYE49_09175	COG2873	o-acetylhomoserine
DYE49_09180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DYE49_09180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DYE49_09180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DYE49_09185	COG1879	ABC-type sugar transport system periplasmic component
DYE49_09225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DYE49_09225	COG0140	phosphoribosyl-ATP diphosphatase activity
DYE49_09230	COG3437	response regulator, receiver
DYE49_09240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DYE49_09250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DYE49_09255	COG2815	serine threonine protein kinase
DYE49_09255	COG0515	serine threonine protein kinase
DYE49_09260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DYE49_09265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DYE49_09275	COG1061	Type III restriction enzyme res subunit
DYE49_09290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DYE49_09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DYE49_09310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DYE49_09315	COG1609	Transcriptional regulator
DYE49_09315	COG2207	Transcriptional regulator
DYE49_09325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DYE49_09335	COG1475	DNA binding
DYE49_09340	COG1192	Involved in chromosome partitioning
DYE49_09380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DYE49_09385	COG1187	pseudouridine synthase activity
DYE49_09395	COG2357	RelA SpoT domain protein
DYE49_09400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DYE49_09405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DYE49_09415	COG4268	DNA restriction-modification system
DYE49_09420	COG1401	restriction endodeoxyribonuclease activity
DYE49_09430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DYE49_09455	COG1846	Transcriptional regulator
DYE49_09525	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DYE49_09530	COG0004	ammonium transporteR
DYE49_09545	COG0067	glutamate synthase
DYE49_09545	COG0070	glutamate synthase
DYE49_09545	COG0069	glutamate synthase activity
DYE49_09550	COG0493	'glutamate synthase
DYE49_09555	COG3707	response regulator
DYE49_09560	COG0174	glutamine synthetase
DYE49_09565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DYE49_09575	COG0367	asparagine synthase
DYE49_09595	COG0494	nUDIX hydrolase
DYE49_09605	COG1283	sodium-dependent phosphate transmembrane transporter activity
DYE49_09615	COG2816	NAD+ diphosphatase activity
DYE49_09620	COG1368	sulfuric ester hydrolase activity
DYE49_09640	COG1131	(ABC) transporter
DYE49_09645	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DYE49_09710	COG0556	nucleotide-excision repair
DYE49_09715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DYE49_09720	COG0321	lipoyl(octanoyl) transferase activity
DYE49_09720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DYE49_09745	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DYE49_09760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DYE49_09765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DYE49_09775	COG1028	Short-chain dehydrogenase reductase Sdr
DYE49_09785	COG4753	response regulator
DYE49_09785	COG2207	Transcriptional regulator
DYE49_09795	COG1472	Belongs to the glycosyl hydrolase 3 family
DYE49_09810	COG2273	Hydrolase Family 16
DYE49_09810	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DYE49_09830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DYE49_09835	COG0107	imidazoleglycerol-phosphate synthase activity
DYE49_09865	COG0328	RNA-DNA hybrid ribonuclease activity
DYE49_09875	COG0525	valine-tRNA ligase activity
DYE49_09880	COG0473	3-isopropylmalate dehydrogenase activity
DYE49_09895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DYE49_09905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DYE49_09910	COG0017	Asparaginyl-tRNA synthetase
DYE49_09925	COG0504	CTP synthase activity
DYE49_09940	COG0517	IMP dehydrogenase activity
DYE49_09940	COG1227	inorganic diphosphatase activity
DYE49_09950	COG1956	GAF domain-containing protein
DYE49_09955	COG2273	Hydrolase Family 16
DYE49_09990	COG0110	maltose O-acetyltransferase activity
DYE49_10075	COG2153	protein acetylation
DYE49_10110	COG3534	alpha-L-arabinofuranosidase
DYE49_10125	COG4999	Histidine kinase
DYE49_10125	COG2205	protein histidine kinase activity
DYE49_10125	COG3437	response regulator, receiver
DYE49_10125	COG3850	Histidine kinase
DYE49_10140	COG0534	Mate efflux family protein
DYE49_10150	COG0058	SHG alpha-glucan phosphorylase activity
DYE49_10160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DYE49_10200	COG0534	Mate efflux family protein
DYE49_10205	COG1640	4-alpha-glucanotransferase
DYE49_10215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DYE49_10240	COG0693	protein deglycase activity
DYE49_10250	COG5002	protein histidine kinase activity
DYE49_10250	COG2205	protein histidine kinase activity
DYE49_10250	COG0784	Response regulator, receiver
DYE49_10260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DYE49_10265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DYE49_10270	COG0484	heat shock protein binding
DYE49_10305	COG0714	Associated with various cellular activities
DYE49_10315	COG1959	2 iron, 2 sulfur cluster binding
DYE49_10320	COG0561	phosphatase activity
DYE49_10375	COG1132	(ABC) transporter
DYE49_10380	COG1132	(ABC) transporter
DYE49_10415	COG0840	transmembrane signaling receptor activity
DYE49_10420	COG0193	aminoacyl-tRNA hydrolase activity
DYE49_10425	COG2217	Heavy metal translocating P-type atpase
DYE49_10430	COG0640	Transcriptional regulator
DYE49_10450	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DYE49_10460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DYE49_10465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DYE49_10470	COG1272	protein, Hemolysin III
DYE49_10475	COG1032	radical SAM domain protein
DYE49_10495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DYE49_10505	COG0840	transmembrane signaling receptor activity
DYE49_10515	COG3012	SEC-C Motif Domain Protein
DYE49_10545	COG0330	HflC and HflK could
DYE49_10550	COG0330	HflC and HflK could
DYE49_10570	COG0442	prolyl-tRNA aminoacylation
DYE49_10575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DYE49_10670	COG0494	nUDIX hydrolase
DYE49_10685	COG4443	Transcriptional Coactivator p15 (PC4)
DYE49_10700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DYE49_10730	COG0840	transmembrane signaling receptor activity
DYE49_10735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DYE49_10775	COG0488	(ABC) transporter
DYE49_10780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DYE49_10785	COG1196	nuclear chromosome segregation
DYE49_10785	COG0741	lytic transglycosylase activity
DYE49_10785	COG0739	heme binding
DYE49_10795	COG1022	Amp-dependent synthetase and ligase
DYE49_10830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DYE49_10835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DYE49_10840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DYE49_10855	COG1966	Carbon starvation protein
DYE49_10870	COG0205	6-phosphofructokinase activity
DYE49_10895	COG0084	hydrolase, TatD family'
DYE49_10925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DYE49_10935	COG4166	transmembrane transport
DYE49_10955	COG0318	PFAM AMP-dependent synthetase and ligase
DYE49_10965	COG3118	belongs to the thioredoxin family
DYE49_10970	COG0492	ferredoxin-NADP+ reductase activity
DYE49_10975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DYE49_10980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DYE49_10995	COG0589	response to stress
DYE49_10995	COG0475	glutathione-regulated potassium exporter activity
DYE49_11020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DYE49_11030	COG1119	ATPase activity
DYE49_11035	COG0534	Mate efflux family protein
DYE49_11040	COG5001	Diguanylate cyclase
DYE49_11040	COG3300	MHYT domain
DYE49_11055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DYE49_11090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DYE49_11095	COG0395	ABC-type sugar transport system, permease component
DYE49_11145	COG3940	Belongs to the glycosyl hydrolase 43 family
DYE49_11205	COG1028	Short-chain dehydrogenase reductase Sdr
DYE49_11220	COG2199	diguanylate cyclase activity
DYE49_11230	COG3250	beta-galactosidase activity
DYE49_11240	COG0395	ABC-type sugar transport system, permease component
DYE49_11280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DYE49_11295	COG0357	Ribosomal RNA small subunit methyltransferase G
DYE49_11320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DYE49_11325	COG0284	orotidine-5'-phosphate decarboxylase activity
DYE49_11330	COG3191	aminopeptidase activity
DYE49_11335	COG0167	dihydroorotate dehydrogenase activity
DYE49_11345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DYE49_11350	COG1121	(ABC) transporter
DYE49_11365	COG1160	GTP binding
DYE49_11380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DYE49_11395	COG5002	protein histidine kinase activity
DYE49_11415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DYE49_11420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DYE49_11510	COG0116	Belongs to the methyltransferase superfamily
DYE49_11530	COG0501	Belongs to the peptidase M48B family
DYE49_11545	COG0540	Belongs to the ATCase OTCase family
DYE49_11590	COG0583	DNA-binding transcription factor activity
DYE49_11600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DYE49_11620	COG3177	Filamentation induced by cAMP protein fic
DYE49_11625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DYE49_11640	COG0174	glutamine synthetase
DYE49_11645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DYE49_11650	COG2199	diguanylate cyclase activity
DYE49_11650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DYE49_11660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DYE49_11680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DYE49_11685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DYE49_11690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DYE49_11700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DYE49_11720	COG3706	GGDEF domain
DYE49_11775	COG0326	Molecular chaperone. Has ATPase activity
DYE49_11785	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DYE49_11795	COG4974	Belongs to the 'phage' integrase family
DYE49_11820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DYE49_11830	COG4608	Belongs to the ABC transporter superfamily
DYE49_11835	COG0444	Belongs to the ABC transporter superfamily
DYE49_11840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DYE49_11845	COG0601	transmembrane transport
DYE49_11850	COG3047	cAMP biosynthetic process
DYE49_11850	COG2885	chlorophyll binding
DYE49_11860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DYE49_11865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DYE49_11870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DYE49_11875	COG1862	Preprotein translocase
DYE49_11890	COG2885	chlorophyll binding
DYE49_11895	COG1388	LysM domain
DYE49_11895	COG0741	lytic transglycosylase activity
DYE49_11965	COG2337	Toxic component of a toxin-antitoxin (TA) module
DYE49_12065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DYE49_12085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DYE49_12090	COG1534	Rna-binding protein
DYE49_12095	COG1328	CTP reductase activity
DYE49_12105	COG4953	penicillin-binding protein 1C
DYE49_12120	COG0564	pseudouridine synthase activity
DYE49_12135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DYE49_12145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DYE49_12150	COG1268	BioY protein
DYE49_12155	COG1122	ATPase activity
DYE49_12200	COG0131	Imidazoleglycerol-phosphate dehydratase
DYE49_12205	COG0577	efflux transmembrane transporter activity
DYE49_12210	COG1136	(ABC) transporter
DYE49_12215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DYE49_12225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DYE49_12225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DYE49_12240	COG0601	transmembrane transport
DYE49_12245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DYE49_12250	COG0444	Belongs to the ABC transporter superfamily
DYE49_12255	COG4608	Belongs to the ABC transporter superfamily
DYE49_12280	COG2364	Membrane