locus-tag	class	description
HRI97_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRI97_00010	COG0592	DNA-directed DNA polymerase activity
HRI97_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRI97_00030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRI97_00065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRI97_00070	COG0594	ribonuclease P activity
HRI97_00075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRI97_00080	COG0706	membrane insertase activity
HRI97_00085	COG1847	R3H domain protein
HRI97_00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRI97_00095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRI97_00095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HRI97_00120	COG1322	Protein conserved in bacteria
HRI97_00130	COG0622	Phosphoesterase
HRI97_00140	COG0395	ABC-type sugar transport system, permease component
HRI97_00145	COG1175	transmembrane transport
HRI97_00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRI97_00185	COG0411	ABC transporter
HRI97_00195	COG0574	Belongs to the PEP-utilizing enzyme family
HRI97_00195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRI97_00200	COG0494	nUDIX hydrolase
HRI97_00220	COG0210	DNA helicase
HRI97_00225	COG3620	sequence-specific DNA binding
HRI97_00255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRI97_00270	COG4133	protoheme IX ABC transporter activity
HRI97_00290	COG1132	(ABC) transporter
HRI97_00300	COG1132	(ABC) transporter
HRI97_00320	COG0697	spore germination
HRI97_00325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRI97_00330	COG2342	PFAM TM1410 hypothetical-related protein
HRI97_00355	COG1362	aminopeptidase activity
HRI97_00370	COG0395	ABC-type sugar transport system, permease component
HRI97_00375	COG1175	transmembrane transport
HRI97_00380	COG1653	transport
HRI97_00385	COG1846	Transcriptional regulator
HRI97_00385	COG1940	carbohydrate kinase activity
HRI97_00390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRI97_00490	COG1609	Transcriptional regulator
HRI97_00495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI97_00505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI97_00505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI97_00510	COG0584	glycerophosphoryl diester phosphodiesterase
HRI97_00520	COG0656	L-ascorbic acid biosynthetic process
HRI97_00530	COG0251	oxidation-reduction process
HRI97_00535	COG1881	PFAM PEBP family protein
HRI97_00575	COG1733	regulation of RNA biosynthetic process
HRI97_00585	COG0698	ribose 5-phosphate isomerase
HRI97_00595	COG1454	alcohol dehydrogenase
HRI97_00600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRI97_00635	COG2197	response regulator
HRI97_00640	COG1435	thymidine kinase activity
HRI97_00645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRI97_00675	COG1309	transcriptional regulator
HRI97_00680	COG0116	Belongs to the methyltransferase superfamily
HRI97_00690	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HRI97_00695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRI97_00705	COG1131	(ABC) transporter
HRI97_00720	COG3976	FMN-binding domain protein
HRI97_00720	COG0431	NADPH-dependent FMN reductase
HRI97_00720	COG1053	succinate dehydrogenase
HRI97_00725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRI97_00745	COG0431	NADPH-dependent FMN reductase
HRI97_00745	COG1053	succinate dehydrogenase
HRI97_00745	COG3976	FMN-binding domain protein
HRI97_00750	COG0167	dihydroorotate dehydrogenase activity
HRI97_00765	COG0385	Bile acid
HRI97_00770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRI97_00800	COG0411	ABC transporter
HRI97_00810	COG2376	Dihydroxyacetone kinase
HRI97_00820	COG3681	Belongs to the UPF0597 family
HRI97_00830	COG0151	Belongs to the GarS family
HRI97_00845	COG3875	lactate racemase activity
HRI97_00860	COG0450	alkyl hydroperoxide reductase
HRI97_00865	COG1794	racemase activity, acting on amino acids and derivatives
HRI97_00870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRI97_00875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRI97_00880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRI97_00895	COG0154	amidase activity
HRI97_00900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRI97_00930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRI97_00950	COG1418	mRNA catabolic process
HRI97_00960	COG3437	response regulator, receiver
HRI97_00970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRI97_00975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRI97_00980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRI97_01000	COG0538	isocitrate dehydrogenase activity
HRI97_01005	COG0436	Aminotransferase
HRI97_01015	COG2198	Histidine kinase
HRI97_01015	COG0643	Histidine kinase
HRI97_01020	COG0835	chemotaxis
HRI97_01030	COG2201	protein-glutamate methylesterase activity
HRI97_01040	COG3330	Domain of unknown function (DUF4912)
HRI97_01070	COG3976	FMN-binding domain protein
HRI97_01070	COG1053	succinate dehydrogenase
HRI97_01075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRI97_01080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRI97_01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRI97_01115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRI97_01125	COG1119	ATPase activity
HRI97_01130	COG3858	chitin binding
HRI97_01140	COG4452	Inner membrane protein CreD
HRI97_01155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRI97_01175	COG0205	6-phosphofructokinase activity
HRI97_01180	COG1704	LemA family
HRI97_01190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HRI97_01200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRI97_01205	COG1122	ATPase activity
HRI97_01220	COG1643	Atp-dependent helicase
HRI97_01260	COG3956	TIGRFAM MazG family protein
HRI97_01265	COG0193	aminoacyl-tRNA hydrolase activity
HRI97_01270	COG2217	Heavy metal translocating P-type atpase
HRI97_01280	COG0640	Transcriptional regulator
HRI97_01300	COG1131	(ABC) transporter
HRI97_01305	COG1970	mechanosensitive ion channel activity
HRI97_01320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HRI97_01330	COG0588	phosphoglycerate mutase activity
HRI97_01345	COG0328	RNA-DNA hybrid ribonuclease activity
HRI97_01355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRI97_01365	COG0423	glycine-tRNA ligase activity
HRI97_01380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRI97_01390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRI97_01395	COG1283	sodium-dependent phosphate transmembrane transporter activity
HRI97_01445	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HRI97_01450	COG0357	Ribosomal RNA small subunit methyltransferase G
HRI97_01470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRI97_01470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRI97_01480	COG1968	undecaprenyl-diphosphatase activity
HRI97_01490	COG4821	SIS domain
HRI97_01510	COG0363	glucosamine-6-phosphate deaminase activity
HRI97_01520	COG1994	Peptidase M50
HRI97_01545	COG0426	domain, Protein
HRI97_01620	COG1674	ftsk spoiiie
HRI97_01630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRI97_01640	COG0668	transmembrane transport
HRI97_01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI97_01650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRI97_01660	COG0737	Belongs to the 5'-nucleotidase family
HRI97_01665	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HRI97_01670	COG0528	UMP kinase activity
HRI97_01680	COG4953	penicillin-binding protein 1C
HRI97_01685	COG2373	Large extracellular alpha-helical protein
HRI97_01695	COG2848	UPF0210 protein
HRI97_01705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRI97_01710	COG0579	oxidoreductase
HRI97_01770	COG3116	cell division
HRI97_01770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRI97_01775	COG0084	hydrolase, TatD family'
HRI97_01810	COG0215	cysteine-tRNA ligase activity
HRI97_01815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRI97_01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRI97_01845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRI97_01875	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRI97_01910	COG1272	protein, Hemolysin III
HRI97_01915	COG0084	hydrolase, TatD family'
HRI97_01920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRI97_01935	COG0442	prolyl-tRNA aminoacylation
HRI97_01950	COG0493	'glutamate synthase
HRI97_01955	COG0543	2 iron, 2 sulfur cluster binding
HRI97_01965	COG2183	response to ionizing radiation
HRI97_01975	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HRI97_02000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HRI97_02005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRI97_02015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRI97_02020	COG0542	response to heat
HRI97_02025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRI97_02030	COG3830	Belongs to the UPF0237 family
HRI97_02035	COG1177	transmembrane transport
HRI97_02045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRI97_02065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRI97_02065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HRI97_02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI97_02075	COG2204	response regulator
HRI97_02105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRI97_02110	COG2195	Cleaves the N-terminal amino acid of tripeptides
HRI97_02130	COG1196	nuclear chromosome segregation
HRI97_02130	COG0741	lytic transglycosylase activity
HRI97_02130	COG0739	heme binding
HRI97_02135	COG0681	Belongs to the peptidase S26 family
HRI97_02140	COG0768	penicillin binding
HRI97_02145	COG2604	Protein of unknown function DUF115
HRI97_02155	COG2873	o-acetylhomoserine
HRI97_02160	COG0840	transmembrane signaling receptor activity
HRI97_02165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRI97_02170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRI97_02180	COG0587	DNA-directed DNA polymerase activity
HRI97_02200	COG0776	regulation of translation
HRI97_02210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRI97_02215	COG0051	transcription antitermination factor activity, RNA binding
HRI97_02220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRI97_02225	COG0088	Forms part of the polypeptide exit tunnel
HRI97_02230	COG0089	rRNA binding
HRI97_02235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRI97_02240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRI97_02245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRI97_02250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRI97_02255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRI97_02260	COG0255	Belongs to the universal ribosomal protein uL29 family
HRI97_02270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRI97_02275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRI97_02280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRI97_02290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRI97_02295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRI97_02300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRI97_02305	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRI97_02310	COG1841	ribosomal large subunit assembly
HRI97_02315	COG0200	Binds to the 23S rRNA
HRI97_02325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRI97_02335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRI97_02340	COG0202	RNA polymerase activity
HRI97_02345	COG0203	ribosomal protein L17
HRI97_02380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRI97_02385	COG1477	protein flavinylation
HRI97_02405	COG1022	Amp-dependent synthetase and ligase
HRI97_02420	COG0492	ferredoxin-NADP+ reductase activity
HRI97_02425	COG1472	Belongs to the glycosyl hydrolase 3 family
HRI97_02435	COG3148	PFAM DTW domain containing protein
HRI97_02445	COG0534	Mate efflux family protein
HRI97_02450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRI97_02450	COG0140	phosphoribosyl-ATP diphosphatase activity
HRI97_02460	COG1686	Belongs to the peptidase S11 family
HRI97_02465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRI97_02470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRI97_02480	COG0058	SHG alpha-glucan phosphorylase activity
HRI97_02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRI97_02495	COG0765	amino acid transport
HRI97_02500	COG1126	abc transporter atp-binding protein
HRI97_02505	COG0534	Mate efflux family protein
HRI97_02520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRI97_02525	COG0268	Binds directly to 16S ribosomal RNA
HRI97_02535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRI97_02545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRI97_02550	COG0254	rRNA binding
HRI97_02560	COG0513	Belongs to the DEAD box helicase family
HRI97_02565	COG0488	(ABC) transporter
HRI97_02575	COG0210	DNA helicase
HRI97_02605	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRI97_02620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRI97_02625	COG2894	cell division
HRI97_02635	COG0616	signal peptide processing
HRI97_02660	COG3842	ATPase activity
HRI97_02675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRI97_02680	COG0443	Heat shock 70 kDa protein
HRI97_02685	COG0484	heat shock protein binding
HRI97_02690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRI97_02710	COG0714	Associated with various cellular activities
HRI97_02740	COG2840	Smr protein MutS2
HRI97_02745	COG0484	heat shock protein binding
HRI97_02750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRI97_02755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HRI97_02790	COG0745	RESPONSE REGULATOR receiver
HRI97_02795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRI97_02805	COG1454	alcohol dehydrogenase
HRI97_02810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRI97_02815	COG1639	'signal transduction protein
HRI97_02825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRI97_02850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRI97_02860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRI97_02865	COG0250	Participates in transcription elongation, termination and antitermination
HRI97_02870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRI97_02875	COG0081	regulation of translation
HRI97_02880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRI97_02885	COG0222	ribosome binding
HRI97_02890	COG0085	RNA polymerase activity
HRI97_02900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRI97_02905	COG0049	tRNA binding
HRI97_02910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRI97_02920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRI97_02925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRI97_02945	COG0799	negative regulation of ribosome biogenesis
HRI97_02965	COG0673	inositol 2-dehydrogenase activity
HRI97_02980	COG0517	IMP dehydrogenase activity
HRI97_02980	COG1227	inorganic diphosphatase activity
HRI97_02985	COG0495	leucyl-tRNA aminoacylation
HRI97_02995	COG0534	Mate efflux family protein
HRI97_03025	COG1983	PspC domain protein
HRI97_03030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRI97_03060	COG3657	addiction module killer protein
HRI97_03065	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRI97_03090	COG1490	D-aminoacyl-tRNA deacylase activity
HRI97_03110	COG1482	cell wall glycoprotein biosynthetic process
HRI97_03115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HRI97_03120	COG1744	ABC transporter substrate-binding protein PnrA-like
HRI97_03125	COG1523	belongs to the glycosyl hydrolase 13 family
HRI97_03170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRI97_03200	COG0330	HflC and HflK could
HRI97_03205	COG0330	HflC and HflK could
HRI97_03225	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRI97_03235	COG0137	argininosuccinate synthase activity
HRI97_03255	COG0431	NADPH-dependent FMN reductase
HRI97_03255	COG1053	succinate dehydrogenase
HRI97_03255	COG3976	FMN-binding domain protein
HRI97_03260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRI97_03260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRI97_03285	COG0514	ATP-dependent DNA helicase (RecQ)
HRI97_03295	COG1105	Belongs to the carbohydrate kinase PfkB family
HRI97_03310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRI97_03315	COG0564	pseudouridine synthase activity
HRI97_03340	COG2610	gluconate transmembrane transporter activity
HRI97_03355	COG1442	glycosyl transferase family 8
HRI97_03390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI97_03415	COG1349	DNA-binding transcription factor activity
HRI97_03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI97_03455	COG1830	Aldolase
HRI97_03460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI97_03460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRI97_03465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRI97_03475	COG0237	dephospho-CoA kinase activity
HRI97_03480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRI97_03480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRI97_03480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRI97_03485	COG0235	Class ii aldolase
HRI97_03495	COG4977	sequence-specific DNA binding
HRI97_03505	COG1070	Carbohydrate kinase
HRI97_03510	COG1879	ABC-type sugar transport system periplasmic component
HRI97_03520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_03525	COG1129	ABC transporter
HRI97_03530	COG4806	L-rhamnose isomerase
HRI97_03555	COG0395	ABC-type sugar transport system, permease component
HRI97_03560	COG1175	transmembrane transport
HRI97_03565	COG1653	transport
HRI97_03570	COG1609	Transcriptional regulator
HRI97_03585	COG1609	Transcriptional regulator
HRI97_03590	COG1653	transport
HRI97_03595	COG1175	transmembrane transport
HRI97_03600	COG0395	ABC-type sugar transport system, permease component
HRI97_03615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRI97_03620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRI97_03645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRI97_03650	COG0124	histidyl-tRNA synthetase
HRI97_03680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRI97_03700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRI97_03705	COG0196	riboflavin kinase activity
HRI97_03715	COG1185	polyribonucleotide nucleotidyltransferase activity
HRI97_03720	COG0756	dUTP diphosphatase activity
HRI97_03735	COG0343	queuine tRNA-ribosyltransferase activity
HRI97_03760	COG0280	phosphate acetyltransferase
HRI97_03775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI97_03805	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRI97_03810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRI97_03815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRI97_03820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRI97_03825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRI97_03830	COG0166	Belongs to the GPI family
HRI97_03855	COG1388	LysM domain
HRI97_03855	COG3942	CHAP domain
HRI97_03860	COG2885	chlorophyll binding
HRI97_03865	COG1126	abc transporter atp-binding protein
HRI97_03875	COG0431	NADPH-dependent FMN reductase
HRI97_03875	COG1053	succinate dehydrogenase
HRI97_03875	COG3976	FMN-binding domain protein
HRI97_03950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRI97_03955	COG1722	exodeoxyribonuclease VII activity
HRI97_04015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRI97_04030	COG3852	Histidine kinase
HRI97_04035	COG2204	response regulator
HRI97_04040	COG0484	heat shock protein binding
HRI97_04045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRI97_04050	COG4786	Flagellar basal body rod
HRI97_04060	COG3951	Flagellar rod assembly protein muramidase FlgJ
HRI97_04070	COG1561	YicC-like family, N-terminal region
HRI97_04075	COG1102	Psort location Cytoplasmic, score
HRI97_04080	COG1194	a g-specific adenine glycosylase
HRI97_04090	COG0602	queuosine metabolic process
HRI97_04095	COG1328	CTP reductase activity
HRI97_04100	COG3001	Fructosamine kinase
HRI97_04115	COG0556	nucleotide-excision repair
HRI97_04130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRI97_04155	COG0295	cytidine deaminase activity
HRI97_04170	COG1464	Belongs to the NlpA lipoprotein family
HRI97_04175	COG0482	sulfurtransferase activity
HRI97_04180	COG3189	MarR family transcriptional regulator
HRI97_04190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRI97_04200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRI97_04215	COG0285	dihydrofolate synthase activity
HRI97_04220	COG0463	Glycosyl transferase, family 2
HRI97_04245	COG0235	Class ii aldolase
HRI97_04250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRI97_04265	COG1702	phosphate starvation-inducible protein PhoH
HRI97_04275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRI97_04310	COG0552	protein localization to endoplasmic reticulum
HRI97_04320	COG4591	ABC-type transport system involved in lipoprotein release permease component
HRI97_04325	COG1136	(ABC) transporter
HRI97_04340	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HRI97_04345	COG0542	response to heat
HRI97_04360	COG1175	transmembrane transport
HRI97_04365	COG0395	ABC-type sugar transport system, permease component
HRI97_04370	COG3250	beta-galactosidase activity
HRI97_04375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRI97_04385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRI97_04395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRI97_04405	COG1104	cysteine desulfurase activity
HRI97_04410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRI97_04420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRI97_04430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRI97_04440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRI97_04450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRI97_04455	COG2375	cellular response to nickel ion
HRI97_04455	COG1132	(ABC) transporter
HRI97_04460	COG1132	(ABC) transporter
HRI97_04465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRI97_04470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRI97_04475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRI97_04485	COG0107	imidazoleglycerol-phosphate synthase activity
HRI97_04490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRI97_04495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRI97_04515	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRI97_04520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRI97_04530	COG1022	Amp-dependent synthetase and ligase
HRI97_04550	COG1175	transmembrane transport
HRI97_04575	COG1175	transmembrane transport
HRI97_04580	COG0395	ABC-type sugar transport system, permease component
HRI97_04590	COG0018	arginyl-trna synthetase
HRI97_04595	COG2084	Dehydrogenase
HRI97_04610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRI97_04615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRI97_04615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRI97_04625	COG1234	tRNA 3'-trailer cleavage
HRI97_04640	COG1737	Transcriptional regulator
HRI97_04645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI97_04655	COG3842	ATPase activity
HRI97_04665	COG0191	fructose-bisphosphate aldolase activity
HRI97_04675	COG3958	Transketolase
HRI97_04680	COG3976	FMN-binding domain protein
HRI97_04680	COG1053	succinate dehydrogenase
HRI97_04685	COG3711	transcriptional antiterminator
HRI97_04715	COG3959	Transketolase, thiamine diphosphate binding domain
HRI97_04720	COG3958	Transketolase
HRI97_04730	COG0322	excinuclease ABC activity
HRI97_04745	COG0006	proline dipeptidase activity
HRI97_04750	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRI97_04760	COG3845	ABC transporter
HRI97_04765	COG1744	ABC transporter substrate-binding protein PnrA-like
HRI97_04830	COG2361	Protein of unknown function DUF86
HRI97_04895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRI97_04900	COG0440	acetolactate synthase activity
HRI97_04905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRI97_04910	COG0632	four-way junction helicase activity
HRI97_04915	COG2255	four-way junction helicase activity
HRI97_04920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRI97_04945	COG0037	tRNA processing
HRI97_04960	COG0481	GTPase activity
HRI97_04970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRI97_04980	COG0601	transmembrane transport
HRI97_04995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRI97_05000	COG0504	CTP synthase activity
HRI97_05010	COG0017	Asparaginyl-tRNA synthetase
HRI97_05015	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HRI97_05020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HRI97_05025	COG0471	metal ion transport
HRI97_05025	COG3273	potassium ion transport
HRI97_05030	COG1802	Transcriptional regulator
HRI97_05040	COG0372	Belongs to the citrate synthase family
HRI97_05075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HRI97_05085	COG0802	atpase or kinase
HRI97_05125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRI97_05135	COG1024	Enoyl-CoA hydratase
HRI97_05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRI97_05150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRI97_05175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRI97_05190	COG1122	ATPase activity
HRI97_05195	COG1268	BioY protein
HRI97_05245	COG4373	Mu-like prophage FluMu protein gp28
HRI97_05325	COG3409	Peptidoglycan-binding domain 1 protein
HRI97_05325	COG3267	Type II secretory pathway component ExeA
HRI97_05355	COG4397	Mu-like prophage major head subunit gpT
HRI97_05450	COG2252	PERMEase
HRI97_05455	COG3422	double-strand break repair
HRI97_05470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRI97_05475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HRI97_05480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRI97_05500	COG2226	methyltransferase
HRI97_05505	COG0346	lactoylglutathione lyase activity
HRI97_05510	COG3549	Plasmid maintenance system killer
HRI97_05540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRI97_05545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRI97_05560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRI97_05560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRI97_05565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRI97_05600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRI97_05610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRI97_05625	COG1132	(ABC) transporter
HRI97_05630	COG1216	Glycosyl transferase, family 2
HRI97_05635	COG0438	transferase activity, transferring glycosyl groups
HRI97_05645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HRI97_05660	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HRI97_05660	COG0028	Belongs to the TPP enzyme family
HRI97_05695	COG1368	sulfuric ester hydrolase activity
HRI97_05700	COG0395	ABC-type sugar transport system, permease component
HRI97_05705	COG1175	transmembrane transport
HRI97_05720	COG2182	Extracellular solute-binding protein
HRI97_05740	COG0436	Aminotransferase
HRI97_05745	COG0297	glycogen (starch) synthase activity
HRI97_05765	COG0750	zinc metalloprotease
HRI97_05770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRI97_05775	COG4589	Belongs to the CDS family
HRI97_05780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRI97_05785	COG0233	cytoplasmic translational termination
HRI97_05790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRI97_05795	COG0052	Belongs to the universal ribosomal protein uS2 family
HRI97_05800	COG0424	maF-like protein
HRI97_05810	COG1413	lyase activity
HRI97_05825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRI97_05830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRI97_05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRI97_05840	COG0571	ribonuclease III activity
HRI97_05870	COG0543	2 iron, 2 sulfur cluster binding
HRI97_05890	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HRI97_05905	COG0114	fumarate hydratase activity
HRI97_05910	COG0039	L-malate dehydrogenase activity
HRI97_05955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRI97_05980	COG0617	tRNA 3'-terminal CCA addition
HRI97_05990	COG0564	pseudouridine synthase activity
HRI97_05995	COG0180	Tryptophanyl-tRNA synthetase
HRI97_06000	COG0708	Exodeoxyribonuclease III
HRI97_06005	COG3976	FMN-binding domain protein
HRI97_06005	COG1053	succinate dehydrogenase
HRI97_06005	COG0431	NADPH-dependent FMN reductase
HRI97_06070	COG0358	DNA primase activity
HRI97_06075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRI97_06095	COG1077	Cell shape determining protein MreB Mrl
HRI97_06110	COG0768	penicillin binding
HRI97_06115	COG0772	Belongs to the SEDS family
HRI97_06145	COG3706	GGDEF domain
HRI97_06160	COG1388	LysM domain
HRI97_06160	COG3942	CHAP domain
HRI97_06175	COG0497	DNA recombination
HRI97_06180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRI97_06185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRI97_06190	COG0835	chemotaxis
HRI97_06195	COG1040	competence protein
HRI97_06200	COG1640	4-alpha-glucanotransferase
HRI97_06215	COG0395	ABC-type sugar transport system, permease component
HRI97_06225	COG0305	Participates in initiation and elongation during chromosome replication
HRI97_06235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRI97_06240	COG0629	single-stranded DNA binding
HRI97_06245	COG0360	Binds together with S18 to 16S ribosomal RNA
HRI97_06285	COG0066	3-isopropylmalate dehydratase activity
HRI97_06315	COG2732	(Barnase) inhibitor
HRI97_06390	COG0564	pseudouridine synthase activity
HRI97_06405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRI97_06410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRI97_06415	COG0658	competence protein
HRI97_06415	COG2333	competence protein COMEC
HRI97_06490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRI97_06495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRI97_06500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRI97_06510	COG0779	Required for maturation of 30S ribosomal subunits
HRI97_06520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI97_06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI97_06530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRI97_06540	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HRI97_06545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRI97_06595	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRI97_06600	COG0740	serine-type endopeptidase activity
HRI97_06605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRI97_06635	COG1196	nuclear chromosome segregation
HRI97_06645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRI97_06655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRI97_06675	COG1121	(ABC) transporter
HRI97_06685	COG0813	purine-nucleoside phosphorylase activity
HRI97_06710	COG2059	Chromate
HRI97_06725	COG0363	glucosamine-6-phosphate deaminase activity
HRI97_06745	COG2204	response regulator
HRI97_06750	COG0539	negative regulation of cytoplasmic translation
HRI97_06760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRI97_06765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRI97_06845	COG3549	Plasmid maintenance system killer
HRI97_06850	COG0514	ATP-dependent DNA helicase (RecQ)
HRI97_06875	COG1609	Transcriptional regulator
HRI97_06885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRI97_06890	COG1120	ATPase activity
HRI97_06895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRI97_06915	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HRI97_06925	COG0396	ATPase activity
HRI97_06935	COG0719	Fe-S assembly protein
HRI97_06940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRI97_06945	COG0822	iron-sulfur transferase activity
HRI97_06960	COG1162	GTPase activity
HRI97_06965	COG1193	negative regulation of DNA recombination
HRI97_06970	COG1438	arginine binding
HRI97_06990	COG0217	transcriptional regulatory protein
HRI97_06995	COG2089	acid synthase
HRI97_07005	COG0653	protein targeting
HRI97_07065	COG4608	Belongs to the ABC transporter superfamily
HRI97_07070	COG0444	Belongs to the ABC transporter superfamily
HRI97_07075	COG0601	transmembrane transport
HRI97_07110	COG1129	ABC transporter
HRI97_07115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_07120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRI97_07125	COG1940	carbohydrate kinase activity
HRI97_07135	COG1879	ABC-type sugar transport system periplasmic component
HRI97_07140	COG0698	ribose 5-phosphate isomerase
HRI97_07145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRI97_07170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRI97_07185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRI97_07195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_07200	COG1129	ABC transporter
HRI97_07220	COG1609	Transcriptional regulator
HRI97_07260	COG4251	negative regulation of phosphorylation
HRI97_07260	COG5001	Diguanylate cyclase
HRI97_07260	COG3706	GGDEF domain
HRI97_07260	COG2203	Gaf domain
HRI97_07265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRI97_07270	COG2604	Protein of unknown function DUF115
HRI97_07280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRI97_07290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRI97_07310	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRI97_07315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HRI97_07320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRI97_07330	COG0731	radical SAM domain protein
HRI97_07340	COG1747	RNA polymerase binding
HRI97_07340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRI97_07350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRI97_07360	COG0126	phosphoglycerate kinase activity
HRI97_07385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRI97_07395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRI97_07405	COG1157	protein secretion by the type III secretion system
HRI97_07410	COG1317	bacterial-type flagellum organization
HRI97_07420	COG1766	The M ring may be actively involved in energy transduction
HRI97_07440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRI97_07445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRI97_07450	COG4974	Belongs to the 'phage' integrase family
HRI97_07455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRI97_07455	COG0551	DNA topoisomerase type I activity
HRI97_07460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRI97_07460	COG0758	DNA mediated transformation
HRI97_07485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRI97_07490	COG0772	Belongs to the SEDS family
HRI97_07495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRI97_07505	COG0275	rRNA processing
HRI97_07510	COG2001	Belongs to the MraZ family
HRI97_07550	COG0346	lactoylglutathione lyase activity
HRI97_07555	COG1683	Conserved Protein
HRI97_07610	COG0191	fructose-bisphosphate aldolase activity
HRI97_07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI97_07630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRI97_07630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRI97_07665	COG0024	Methionine aminopeptidase
HRI97_07670	COG0484	heat shock protein binding
HRI97_07680	COG1394	ATPase activity, coupled to movement of substances
HRI97_07685	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HRI97_07690	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HRI97_07700	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HRI97_07710	COG1269	ATP hydrolysis coupled proton transport
HRI97_07730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRI97_07775	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRI97_07795	COG1879	ABC-type sugar transport system periplasmic component
HRI97_07800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_07810	COG1869	D-ribose catabolic process
HRI97_07815	COG1609	Transcriptional regulator
HRI97_07825	COG4475	Protein of unknown function (DUF436)
HRI97_07840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRI97_07850	COG1269	ATP hydrolysis coupled proton transport
HRI97_07855	COG1394	ATPase activity, coupled to movement of substances
HRI97_07860	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HRI97_07865	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HRI97_07875	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HRI97_07900	COG1191	sigma factor activity
HRI97_07920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRI97_07925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRI97_07930	COG1684	flagellar biosynthetic protein fliR
HRI97_07935	COG1987	bacterial-type flagellum assembly
HRI97_07940	COG1338	Plays a role in the flagellum-specific transport system
HRI97_07950	COG1776	CheC inhibitor of MCP methylation
HRI97_07950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRI97_07955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRI97_07960	COG1580	Controls the rotational direction of flagella during chemotaxis
HRI97_07965	COG1360	Flagellar Motor Protein
HRI97_07970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRI97_07975	COG1582	Flagellar protein (FlbD)
HRI97_07980	COG0745	RESPONSE REGULATOR receiver
HRI97_07985	COG5002	protein histidine kinase activity
HRI97_08000	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HRI97_08005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRI97_08025	COG1393	Belongs to the ArsC family
HRI97_08060	COG0009	L-threonylcarbamoyladenylate synthase
HRI97_08100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI97_08115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRI97_08125	COG1830	Aldolase
HRI97_08130	COG1879	ABC-type sugar transport system periplasmic component
HRI97_08140	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_08150	COG2390	Transcriptional regulator
HRI97_08155	COG1070	Carbohydrate kinase
HRI97_08170	COG0523	cobalamin synthesis protein
HRI97_08185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRI97_08200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRI97_08205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRI97_08220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRI97_08235	COG1671	Belongs to the UPF0178 family
HRI97_08240	COG3437	response regulator, receiver
HRI97_08240	COG0784	Response regulator, receiver
HRI97_08245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRI97_08245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRI97_08250	COG1472	Belongs to the glycosyl hydrolase 3 family
HRI97_08255	COG4221	oxidoreductase activity
HRI97_08315	COG4211	Belongs to the binding-protein-dependent transport system permease family
HRI97_08320	COG1129	ABC transporter
HRI97_08325	COG1879	ABC-type sugar transport system periplasmic component
HRI97_08330	COG0765	amino acid transport
HRI97_08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRI97_08350	COG0301	tRNA thio-modification
HRI97_08365	COG1573	uracil-dna glycosylase
HRI97_08370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRI97_08385	COG0736	holo-[acyl-carrier-protein] synthase activity
HRI97_08395	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HRI97_08400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRI97_08405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRI97_08435	COG0826	peptidase U32
HRI97_08440	COG0657	acetylesterase activity
HRI97_08445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRI97_08455	COG2972	Histidine kinase
HRI97_08460	COG4753	response regulator
HRI97_08460	COG2207	Transcriptional regulator
HRI97_08480	COG1285	pathogenesis
HRI97_08490	COG2972	Histidine kinase
HRI97_08495	COG2207	Transcriptional regulator
HRI97_08495	COG4753	response regulator
HRI97_08510	COG3842	ATPase activity
HRI97_08520	COG1028	Short-chain dehydrogenase reductase Sdr
HRI97_08540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRI97_08550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRI97_08555	COG0445	tRNA wobble uridine modification
HRI97_08570	COG2239	Acts as a magnesium transporter
HRI97_08580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI97_08595	COG0501	Belongs to the peptidase M48B family
HRI97_08600	COG0656	L-ascorbic acid biosynthetic process
HRI97_08605	COG4221	oxidoreductase activity
HRI97_08610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRI97_08620	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HRI97_08680	COG0563	adenylate kinase activity
HRI97_08685	COG1929	Belongs to the glycerate kinase type-1 family
HRI97_08690	COG0039	L-malate dehydrogenase activity
HRI97_08695	COG0728	peptidoglycan biosynthetic process
HRI97_08700	COG1966	Carbon starvation protein
HRI97_08710	COG0028	Belongs to the TPP enzyme family
HRI97_08715	COG0129	dihydroxy-acid dehydratase activity
HRI97_08725	COG1063	alcohol dehydrogenase
HRI97_08735	COG0371	Dehydrogenase
HRI97_08745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRI97_08760	COG0840	transmembrane signaling receptor activity
HRI97_08770	COG1739	Uncharacterized protein family UPF0029
HRI97_08815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRI97_08820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRI97_08825	COG0564	pseudouridine synthase activity
HRI97_08830	COG2502	aspartate--ammonia ligase
HRI97_08835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRI97_08840	COG0287	Prephenate dehydrogenase
HRI97_08845	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRI97_08850	COG1132	(ABC) transporter
HRI97_08855	COG1132	(ABC) transporter
HRI97_08860	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HRI97_08865	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRI97_08875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRI97_08885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRI97_08890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRI97_08895	COG1862	Preprotein translocase
HRI97_08925	COG1373	ATPase (AAA superfamily
HRI97_08940	COG0084	hydrolase, TatD family'
HRI97_08960	COG1349	DNA-binding transcription factor activity
HRI97_08965	COG3395	kinase activity
HRI97_08970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRI97_08975	COG2610	gluconate transmembrane transporter activity
HRI97_08980	COG1473	amidohydrolase
HRI97_08990	COG2011	ABC-type metal ion transport system permease component
HRI97_08995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRI97_09000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRI97_09005	COG2610	gluconate transmembrane transporter activity
HRI97_09010	COG0028	Belongs to the TPP enzyme family
HRI97_09015	COG0840	transmembrane signaling receptor activity
HRI97_09035	COG0513	Belongs to the DEAD box helicase family
HRI97_09045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRI97_09045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRI97_09070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI97_09085	COG1151	hydroxylamine reductase activity
HRI97_09125	COG3048	D-serine ammonia-lyase activity
HRI97_09135	COG1757	Na H antiporter
HRI97_09140	COG3976	FMN-binding domain protein
HRI97_09140	COG1053	succinate dehydrogenase
HRI97_09160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRI97_09165	COG0037	tRNA processing
HRI97_09170	COG0800	Aldolase
HRI97_09205	COG0335	large ribosomal subunit rRNA binding
HRI97_09210	COG0336	Belongs to the RNA methyltransferase TrmD family
HRI97_09220	COG1837	Belongs to the UPF0109 family
HRI97_09225	COG0228	four-way junction DNA binding
HRI97_09235	COG0110	maltose O-acetyltransferase activity
HRI97_09250	COG1088	dTDP-glucose 4,6-dehydratase activity
HRI97_09265	COG0028	Belongs to the TPP enzyme family
HRI97_09305	COG0542	response to heat
HRI97_09330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRI97_09350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRI97_09390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRI97_09455	COG4585	Histidine kinase
HRI97_09480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRI97_09490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRI97_09500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HRI97_09500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HRI97_09500	COG1013	pyruvate-flavodoxin oxidoreductase activity
HRI97_09500	COG0674	pyruvate-flavodoxin oxidoreductase activity
HRI97_09505	COG0517	IMP dehydrogenase activity
HRI97_09505	COG0516	GMP reductase activity
HRI97_09560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRI97_09565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRI97_09585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRI97_09615	COG0557	exoribonuclease II activity
HRI97_09635	COG3842	ATPase activity
HRI97_09645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRI97_09650	COG2078	PFAM AMMECR1 domain protein
HRI97_09650	COG3885	ferrous iron binding
HRI97_09660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRI97_09665	COG0826	peptidase U32
HRI97_09670	COG1687	branched-chain amino acid
HRI97_09675	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HRI97_09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRI97_09710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRI97_09715	COG0321	lipoyl(octanoyl) transferase activity
HRI97_09715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRI97_09720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRI97_09755	COG3842	ATPase activity
HRI97_09775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRI97_09780	COG1757	Na H antiporter
HRI97_09800	COG1199	ATP-dependent helicase activity
HRI97_09805	COG1011	Hydrolase
HRI97_09820	COG0525	valine-tRNA ligase activity
HRI97_09830	COG2003	Belongs to the UPF0758 family
HRI97_09840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI97_09845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRI97_09850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRI97_09865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRI97_09875	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRI97_09885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRI97_09890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRI97_09900	COG4536	flavin adenine dinucleotide binding
HRI97_09905	COG4536	flavin adenine dinucleotide binding
HRI97_09915	COG0564	pseudouridine synthase activity
HRI97_09935	COG0588	phosphoglycerate mutase activity
HRI97_09945	COG1937	Protein conserved in bacteria
HRI97_09950	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRI97_09955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRI97_09960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRI97_09965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRI97_09970	COG2033	superoxide reductase activity
HRI97_09975	COG0657	acetylesterase activity
HRI97_09975	COG2755	lipolytic protein G-D-S-L family
HRI97_10025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI97_10065	COG2161	toxin-antitoxin pair type II binding
HRI97_10140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRI97_10150	COG0670	Belongs to the BI1 family
HRI97_10155	COG2233	PERMEase
HRI97_10165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRI97_10170	COG0131	Imidazoleglycerol-phosphate dehydratase
HRI97_10175	COG3340	Belongs to the peptidase S51 family
HRI97_10190	COG1879	ABC-type sugar transport system periplasmic component
HRI97_10200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_10210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRI97_10215	COG2890	protein-(glutamine-N5) methyltransferase activity
HRI97_10220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRI97_10230	COG0629	single-stranded DNA binding
HRI97_10245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRI97_10305	COG1116	anion transmembrane transporter activity
HRI97_10310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRI97_10325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRI97_10330	COG0724	RNA recognition motif
HRI97_10340	COG2885	chlorophyll binding
HRI97_10350	COG1177	transmembrane transport
HRI97_10355	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRI97_10360	COG3842	ATPase activity
HRI97_10435	COG1309	transcriptional regulator
HRI97_10445	COG0793	Belongs to the peptidase S41A family
HRI97_10455	COG0459	protein refolding
HRI97_10475	COG4166	transmembrane transport
HRI97_10510	COG1476	TRANSCRIPTIONal
HRI97_10530	COG2011	ABC-type metal ion transport system permease component
HRI97_10535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRI97_10550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRI97_10560	COG0739	heme binding
HRI97_10565	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRI97_10570	COG0142	geranyltranstransferase activity
HRI97_10585	COG2201	protein-glutamate methylesterase activity
HRI97_10600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRI97_10605	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRI97_10610	COG4603	Belongs to the binding-protein-dependent transport system permease family
HRI97_10615	COG3845	ABC transporter
HRI97_10635	COG3976	FMN-binding domain protein
HRI97_10635	COG1053	succinate dehydrogenase
HRI97_10650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRI97_10655	COG2226	methyltransferase
HRI97_10660	COG1774	PSP1 C-terminal conserved region
HRI97_10675	COG0739	heme binding
HRI97_10690	COG1716	ATPase activity
HRI97_10690	COG5001	Diguanylate cyclase
HRI97_10740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRI97_10745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRI97_10770	COG1175	transmembrane transport
HRI97_10775	COG3833	ABC-type maltose transport systems, permease component
HRI97_10780	COG0366	Alpha amylase catalytic
HRI97_10800	COG0436	Aminotransferase
HRI97_10805	COG1522	sequence-specific DNA binding
HRI97_10830	COG1192	Involved in chromosome partitioning
HRI97_10835	COG1475	DNA binding
HRI97_10845	COG3842	ATPase activity
HRI97_10860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HRI97_10865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI97_10870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI97_10875	COG1121	(ABC) transporter
HRI97_10880	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRI97_10885	COG1321	iron dependent repressor
HRI97_10895	COG0740	serine-type endopeptidase activity
HRI97_10905	COG0724	RNA recognition motif
HRI97_10910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRI97_10915	COG1074	ATP-dependent DNA helicase activity
HRI97_10945	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRI97_10950	COG3842	ATPase activity
HRI97_10955	COG4608	Belongs to the ABC transporter superfamily
HRI97_10960	COG0444	Belongs to the ABC transporter superfamily
HRI97_10965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRI97_10970	COG0601	transmembrane transport
HRI97_10985	COG2878	Part of a membrane complex involved in electron transport
HRI97_10990	COG4657	Part of a membrane complex involved in electron transport
HRI97_10995	COG4660	Part of a membrane complex involved in electron transport
HRI97_11005	COG4658	electron transport chain
HRI97_11010	COG4656	Part of a membrane complex involved in electron transport
HRI97_11055	COG0504	CTP synthase activity
HRI97_11060	COG0492	ferredoxin-NADP+ reductase activity
HRI97_11090	COG2207	Transcriptional regulator
HRI97_11100	COG3842	ATPase activity
HRI97_11105	COG1178	ABC-type Fe3 transport system permease component
HRI97_11110	COG3842	ATPase activity
HRI97_11140	COG0733	neurotransmitter:sodium symporter activity
HRI97_11150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRI97_11175	COG0534	Mate efflux family protein
HRI97_11190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRI97_11195	COG3012	SEC-C Motif Domain Protein
HRI97_11200	COG1979	alcohol dehydrogenase
HRI97_11245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRI97_11270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRI97_11270	COG1918	ferrous iron import across plasma membrane
HRI97_11285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRI97_11305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRI97_11315	COG1904	glucuronate isomerase
HRI97_11320	COG0246	Mannitol dehydrogenase
HRI97_11325	COG1312	Catalyzes the dehydration of D-mannonate
HRI97_11345	COG0737	Belongs to the 5'-nucleotidase family
HRI97_11360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRI97_11365	COG1121	(ABC) transporter
HRI97_11385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRI97_11390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRI97_11395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRI97_11415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRI97_11455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRI97_11490	COG0488	(ABC) transporter
HRI97_11500	COG0038	chloride channel
HRI97_11505	COG0791	NLP P60 protein
HRI97_11505	COG1388	LysM domain
HRI97_11580	COG1136	(ABC) transporter
HRI97_11610	COG1115	amino acid carrier protein
HRI97_11625	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_11630	COG1129	ABC transporter
HRI97_11635	COG1869	D-ribose catabolic process
HRI97_11640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI97_11645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRI97_11680	COG0494	nUDIX hydrolase
HRI97_11695	COG2986	histidine ammonia-lyase
HRI97_11700	COG0534	Mate efflux family protein
HRI97_11705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRI97_11710	COG1028	Short-chain dehydrogenase reductase Sdr
HRI97_11720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRI97_11760	COG2226	methyltransferase
HRI97_11775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRI97_11785	COG1309	transcriptional regulator
HRI97_11790	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HRI97_11830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRI97_11830	COG0248	Ppx GppA phosphatase
HRI97_11845	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRI97_11850	COG3657	addiction module killer protein
HRI97_11885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRI97_11895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRI97_11900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRI97_11940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRI97_11955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRI97_11960	COG0012	GTP binding
HRI97_11965	COG0488	(ABC) transporter
HRI97_11980	COG0494	nUDIX hydrolase
HRI97_11995	COG0534	Mate efflux family protein
HRI97_12005	COG1879	ABC-type sugar transport system periplasmic component
HRI97_12015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_12020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_12025	COG1879	ABC-type sugar transport system periplasmic component
HRI97_12030	COG2972	Histidine kinase
HRI97_12035	COG2207	Transcriptional regulator
HRI97_12035	COG4753	response regulator
HRI97_12040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRI97_12045	COG0783	Belongs to the Dps family
HRI97_12120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRI97_12140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRI97_12155	COG0148	phosphopyruvate hydratase activity
HRI97_12160	COG2226	methyltransferase
HRI97_12165	COG2226	methyltransferase
HRI97_12210	COG4206	TonB-dependent receptor
HRI97_12220	COG0848	biopolymer transport protein
HRI97_12225	COG0811	peptide transport
HRI97_12245	COG4988	ABC transporter
HRI97_12250	COG1132	(ABC) transporter
HRI97_12255	COG2832	Protein of unknown function (DUF454)
HRI97_12260	COG3842	ATPase activity
HRI97_12265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRI97_12285	COG1573	uracil-dna glycosylase
HRI97_12300	COG3976	FMN-binding domain protein
HRI97_12300	COG1053	succinate dehydrogenase
HRI97_12305	COG3976	FMN-binding domain protein
HRI97_12305	COG1053	succinate dehydrogenase
HRI97_12320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HRI97_12330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRI97_12340	COG0326	Molecular chaperone. Has ATPase activity
HRI97_12350	COG1053	succinate dehydrogenase
HRI97_12355	COG4443	Transcriptional Coactivator p15 (PC4)
HRI97_12360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRI97_12395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRI97_12400	COG1047	Peptidyl-prolyl cis-trans
HRI97_12420	COG1592	Rubrerythrin
HRI97_12425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRI97_12435	COG1070	Carbohydrate kinase
HRI97_12440	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRI97_12445	COG1129	ABC transporter
HRI97_12465	COG1349	DNA-binding transcription factor activity
HRI97_12495	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HRI97_12500	COG1518	maintenance of DNA repeat elements
HRI97_12545	COG0071	Belongs to the small heat shock protein (HSP20) family
HRI97_12565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRI97_12570	COG0187	DNA topoisomerase II activity