locus-tag	class	description
HYB91_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYB91_00015	COG0587	DNA-directed DNA polymerase activity
HYB91_00040	COG0840	transmembrane signaling receptor activity
HYB91_00045	COG1132	(ABC) transporter
HYB91_00050	COG1132	(ABC) transporter
HYB91_00090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYB91_00105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYB91_00110	COG1360	Flagellar Motor Protein
HYB91_00115	COG1580	Controls the rotational direction of flagella during chemotaxis
HYB91_00120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_00125	COG1776	CheC inhibitor of MCP methylation
HYB91_00125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_00135	COG1338	Plays a role in the flagellum-specific transport system
HYB91_00145	COG2361	Protein of unknown function DUF86
HYB91_00155	COG4166	transmembrane transport
HYB91_00160	COG2423	ornithine cyclodeaminase activity
HYB91_00165	COG0739	heme binding
HYB91_00170	COG4545	Glutaredoxin-related protein
HYB91_00185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYB91_00210	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HYB91_00225	COG0732	type I restriction modification DNA specificity domain
HYB91_00230	COG4974	Belongs to the 'phage' integrase family
HYB91_00250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYB91_00250	COG3116	cell division
HYB91_00255	COG0084	hydrolase, TatD family'
HYB91_00265	COG1373	ATPase (AAA superfamily
HYB91_00270	COG2203	Gaf domain
HYB91_00270	COG2199	diguanylate cyclase activity
HYB91_00280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYB91_00305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYB91_00315	COG2239	Acts as a magnesium transporter
HYB91_00325	COG0546	phosphoglycolate phosphatase activity
HYB91_00345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYB91_00385	COG2211	Major facilitator Superfamily
HYB91_00435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYB91_00435	COG1747	RNA polymerase binding
HYB91_00450	COG0504	CTP synthase activity
HYB91_00465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYB91_00470	COG1419	protein localization to endoplasmic reticulum
HYB91_00485	COG1191	sigma factor activity
HYB91_00520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYB91_00550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYB91_00555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_00560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYB91_00570	COG0516	GMP reductase activity
HYB91_00575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYB91_00595	COG3437	response regulator, receiver
HYB91_00595	COG0784	Response regulator, receiver
HYB91_00600	COG1797	cobyrinic acid a,c-diamide synthase activity
HYB91_00630	COG1122	ATPase activity
HYB91_00635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYB91_00640	COG1131	(ABC) transporter
HYB91_00650	COG0095	Lipoate-protein ligase
HYB91_00655	COG0517	IMP dehydrogenase activity
HYB91_00655	COG4175	Glycine betaine
HYB91_00665	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYB91_00670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYB91_00670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYB91_00680	COG3177	Filamentation induced by cAMP protein fic
HYB91_00720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_00730	COG0747	negative chemotaxis
HYB91_00740	COG1132	(ABC) transporter
HYB91_00740	COG2375	cellular response to nickel ion
HYB91_00745	COG1132	(ABC) transporter
HYB91_00760	COG1129	ABC transporter
HYB91_00770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYB91_00785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYB91_00790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYB91_00795	COG1477	protein flavinylation
HYB91_00815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_00830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYB91_00835	COG0406	alpha-ribazole phosphatase activity
HYB91_00845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYB91_00855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYB91_00865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYB91_00875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYB91_00900	COG0724	RNA recognition motif
HYB91_00905	COG1054	Belongs to the UPF0176 family
HYB91_00910	COG1362	aminopeptidase activity
HYB91_00925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYB91_00930	COG3290	protein histidine kinase activity
HYB91_00930	COG0840	transmembrane signaling receptor activity
HYB91_00955	COG3706	GGDEF domain
HYB91_00960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYB91_00975	COG0564	pseudouridine synthase activity
HYB91_00985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYB91_00990	COG0166	Belongs to the GPI family
HYB91_00995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_01000	COG4443	Transcriptional Coactivator p15 (PC4)
HYB91_01005	COG0328	RNA-DNA hybrid ribonuclease activity
HYB91_01010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HYB91_01015	COG0301	tRNA thio-modification
HYB91_01045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_01050	COG1121	(ABC) transporter
HYB91_01055	COG4988	ABC transporter
HYB91_01060	COG1132	(ABC) transporter
HYB91_01070	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYB91_01075	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYB91_01080	COG1132	(ABC) transporter
HYB91_01105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYB91_01155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYB91_01190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYB91_01205	COG2604	Protein of unknown function DUF115
HYB91_01240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYB91_01265	COG0357	Ribosomal RNA small subunit methyltransferase G
HYB91_01270	COG1012	belongs to the aldehyde dehydrogenase family
HYB91_01275	COG1132	(ABC) transporter
HYB91_01280	COG1132	(ABC) transporter
HYB91_01305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYB91_01340	COG0840	transmembrane signaling receptor activity
HYB91_01355	COG1573	uracil-dna glycosylase
HYB91_01360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYB91_01365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYB91_01410	COG0326	Molecular chaperone. Has ATPase activity
HYB91_01420	COG0322	excinuclease ABC activity
HYB91_01425	COG1921	L-seryl-tRNASec selenium transferase activity
HYB91_01430	COG0549	Belongs to the carbamate kinase family
HYB91_01435	COG0534	Mate efflux family protein
HYB91_01445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYB91_01455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYB91_01470	COG0425	Belongs to the sulfur carrier protein TusA family
HYB91_01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYB91_01530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYB91_01555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYB91_01560	COG0666	response to abiotic stimulus
HYB91_01565	COG3885	ferrous iron binding
HYB91_01565	COG2078	PFAM AMMECR1 domain protein
HYB91_01580	COG0281	malic enzyme
HYB91_01590	COG2274	protein secretion by the type I secretion system
HYB91_01595	COG1363	Peptidase, m42
HYB91_01600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYB91_01660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYB91_01670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYB91_01675	COG0250	Participates in transcription elongation, termination and antitermination
HYB91_01680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYB91_01685	COG0081	regulation of translation
HYB91_01690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYB91_01695	COG0222	ribosome binding
HYB91_01700	COG0085	RNA polymerase activity
HYB91_01705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYB91_01745	COG0058	SHG alpha-glucan phosphorylase activity
HYB91_01750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYB91_01765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYB91_01785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYB91_01795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYB91_01800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYB91_01810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYB91_01815	COG0706	membrane insertase activity
HYB91_01820	COG1847	R3H domain protein
HYB91_01830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYB91_01840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYB91_01845	COG0740	serine-type endopeptidase activity
HYB91_01860	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYB91_01870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYB91_01880	COG4585	Histidine kinase
HYB91_01895	COG1131	(ABC) transporter
HYB91_01900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYB91_01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYB91_01935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYB91_01940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYB91_01980	COG2376	Dihydroxyacetone kinase
HYB91_01985	COG2376	Dihydroxyacetone kinase
HYB91_01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_02005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HYB91_02010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYB91_02035	COG1413	lyase activity
HYB91_02040	COG0424	maF-like protein
HYB91_02045	COG0052	Belongs to the universal ribosomal protein uS2 family
HYB91_02050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYB91_02055	COG0233	cytoplasmic translational termination
HYB91_02060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYB91_02065	COG0575	Belongs to the CDS family
HYB91_02070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYB91_02075	COG0750	zinc metalloprotease
HYB91_02085	COG0495	leucyl-tRNA aminoacylation
HYB91_02100	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYB91_02105	COG0210	DNA helicase
HYB91_02115	COG2949	membrane
HYB91_02135	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HYB91_02140	COG0542	response to heat
HYB91_02145	COG1492	cobalamin metabolic process
HYB91_02155	COG2197	response regulator
HYB91_02160	COG0668	transmembrane transport
HYB91_02185	COG0739	heme binding
HYB91_02185	COG0741	lytic transglycosylase activity
HYB91_02185	COG1196	nuclear chromosome segregation
HYB91_02190	COG1272	protein, Hemolysin III
HYB91_02205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYB91_02225	COG3604	Transcriptional regulator
HYB91_02245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYB91_02260	COG0792	nuclease activity
HYB91_02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_02280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYB91_02285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_02300	COG0668	transmembrane transport
HYB91_02315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYB91_02320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYB91_02320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYB91_02325	COG1329	Transcriptional regulator
HYB91_02330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYB91_02340	COG0545	Peptidyl-prolyl cis-trans isomerase
HYB91_02345	COG3956	TIGRFAM MazG family protein
HYB91_02360	COG0577	efflux transmembrane transporter activity
HYB91_02360	COG1136	(ABC) transporter
HYB91_02365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HYB91_02395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYB91_02405	COG0101	tRNA pseudouridine synthase activity
HYB91_02420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYB91_02425	COG0840	transmembrane signaling receptor activity
HYB91_02430	COG1132	(ABC) transporter
HYB91_02440	COG0826	peptidase U32
HYB91_02445	COG0737	Belongs to the 5'-nucleotidase family
HYB91_02475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYB91_02500	COG3142	Participates in the control of copper homeostasis
HYB91_02535	COG4865	methylaspartate mutase activity
HYB91_02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_02555	COG1120	ATPase activity
HYB91_02575	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYB91_02585	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYB91_02605	COG0442	prolyl-tRNA aminoacylation
HYB91_02620	COG1879	ABC-type sugar transport system periplasmic component
HYB91_02625	COG1129	ABC transporter
HYB91_02630	COG4211	Belongs to the binding-protein-dependent transport system permease family
HYB91_02645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_02665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYB91_02670	COG2056	Na+-H+ antiporter family
HYB91_02675	COG1757	Na H antiporter
HYB91_02685	COG0626	cystathionine gamma-synthase activity
HYB91_02690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYB91_02705	COG0156	8-amino-7-oxononanoate synthase activity
HYB91_02715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYB91_02725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYB91_02725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYB91_02730	COG0739	heme binding
HYB91_02740	COG1475	DNA binding
HYB91_02745	COG1022	Amp-dependent synthetase and ligase
HYB91_02770	COG0671	phosphoesterase, PA-phosphatase related
HYB91_02775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYB91_02830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYB91_02840	COG2738	Putative neutral zinc metallopeptidase
HYB91_02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYB91_02845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYB91_02850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYB91_02860	COG1129	ABC transporter
HYB91_02875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYB91_02880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYB91_02890	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYB91_02895	COG1671	Belongs to the UPF0178 family
HYB91_02905	COG1388	LysM domain
HYB91_02905	COG0741	lytic transglycosylase activity
HYB91_02930	COG3681	Belongs to the UPF0597 family
HYB91_02935	COG4953	penicillin-binding protein 1C
HYB91_02940	COG1770	oligopeptidase
HYB91_02970	COG1122	ATPase activity
HYB91_03010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYB91_03055	COG1131	(ABC) transporter
HYB91_03075	COG0284	orotidine-5'-phosphate decarboxylase activity
HYB91_03080	COG0513	Belongs to the DEAD box helicase family
HYB91_03090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYB91_03120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYB91_03130	COG3876	Protein conserved in bacteria
HYB91_03135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYB91_03155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYB91_03160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYB91_03165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYB91_03170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYB91_03175	COG0484	heat shock protein binding
HYB91_03180	COG0528	UMP kinase activity
HYB91_03185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HYB91_03200	COG0539	negative regulation of cytoplasmic translation
HYB91_03205	COG2204	response regulator
HYB91_03210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HYB91_03225	COG5001	Diguanylate cyclase
HYB91_03230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYB91_03255	COG0251	oxidation-reduction process
HYB91_03265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYB91_03270	COG1722	exodeoxyribonuclease VII activity
HYB91_03280	COG1918	ferrous iron import across plasma membrane
HYB91_03285	COG1918	ferrous iron import across plasma membrane
HYB91_03285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYB91_03330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYB91_03350	COG4166	transmembrane transport
HYB91_03365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYB91_03380	COG0552	protein localization to endoplasmic reticulum
HYB91_03390	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYB91_03395	COG1136	(ABC) transporter
HYB91_03405	COG3880	PFAM UvrB UvrC protein
HYB91_03410	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYB91_03420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYB91_03425	COG0438	transferase activity, transferring glycosyl groups
HYB91_03435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYB91_03445	COG0084	hydrolase, TatD family'
HYB91_03450	COG2885	chlorophyll binding
HYB91_03515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYB91_03520	COG1132	(ABC) transporter
HYB91_03525	COG1132	(ABC) transporter
HYB91_03525	COG2375	cellular response to nickel ion
HYB91_03535	COG1309	transcriptional regulator
HYB91_03550	COG1164	Oligoendopeptidase f
HYB91_03555	COG1132	(ABC) transporter
HYB91_03560	COG1132	(ABC) transporter
HYB91_03590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYB91_03595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYB91_03610	COG0606	chelatase, subunit chli
HYB91_03620	COG2885	chlorophyll binding
HYB91_03620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYB91_03630	COG1199	ATP-dependent helicase activity
HYB91_03640	COG0823	Involved in the tonB-independent uptake of proteins
HYB91_03655	COG4254	PFAM FecR protein
HYB91_03705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYB91_03710	COG1286	toxin biosynthetic process
HYB91_03715	COG0470	DNA polymerase III
HYB91_03720	COG3852	Histidine kinase
HYB91_03725	COG2204	response regulator
HYB91_03730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HYB91_03745	COG0475	glutathione-regulated potassium exporter activity
HYB91_03750	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYB91_03795	COG1234	tRNA 3'-trailer cleavage
HYB91_03800	COG1744	ABC transporter substrate-binding protein PnrA-like
HYB91_03805	COG3845	ABC transporter
HYB91_03810	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYB91_03815	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYB91_03845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYB91_03900	COG0295	cytidine deaminase activity
HYB91_03935	COG1047	Peptidyl-prolyl cis-trans
HYB91_03955	COG0731	radical SAM domain protein
HYB91_03965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYB91_03970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYB91_03975	COG1979	alcohol dehydrogenase
HYB91_03980	COG2255	four-way junction helicase activity
HYB91_03990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYB91_03995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYB91_04010	COG0736	holo-[acyl-carrier-protein] synthase activity
HYB91_04025	COG1725	Transcriptional regulator
HYB91_04030	COG0653	protein targeting
HYB91_04035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYB91_04040	COG0138	bifunctional purine biosynthesis protein purh
HYB91_04045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYB91_04050	COG2878	Part of a membrane complex involved in electron transport
HYB91_04055	COG0481	GTPase activity
HYB91_04065	COG1114	Component of the transport system for branched-chain amino acids
HYB91_04080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_04095	COG2723	6-phospho-beta-galactosidase activity
HYB91_04110	COG0488	(ABC) transporter
HYB91_04120	COG0793	Belongs to the peptidase S41A family
HYB91_04195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYB91_04200	COG0632	four-way junction helicase activity
HYB91_04250	COG1136	(ABC) transporter
HYB91_04255	COG1136	(ABC) transporter
HYB91_04255	COG0577	efflux transmembrane transporter activity
HYB91_04530	COG2226	methyltransferase
HYB91_04545	COG1418	mRNA catabolic process
HYB91_04570	COG2033	superoxide reductase activity
HYB91_04575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYB91_04580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYB91_04590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYB91_04595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYB91_04610	COG0799	negative regulation of ribosome biogenesis
HYB91_04615	COG2059	Chromate
HYB91_04655	COG0739	heme binding
HYB91_04665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYB91_04675	COG0708	Exodeoxyribonuclease III
HYB91_04680	COG0024	Methionine aminopeptidase
HYB91_04695	COG3250	beta-galactosidase activity
HYB91_04710	COG1233	COG1233 Phytoene dehydrogenase and related
HYB91_04715	COG1017	nitric oxide dioxygenase activity
HYB91_04715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYB91_04735	COG0617	tRNA 3'-terminal CCA addition
HYB91_04755	COG0519	Catalyzes the synthesis of GMP from XMP
HYB91_04770	COG0126	phosphoglycerate kinase activity
HYB91_04775	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYB91_04795	COG0268	Binds directly to 16S ribosomal RNA
HYB91_04800	COG0776	regulation of translation
HYB91_04805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYB91_04815	COG1058	Belongs to the CinA family
HYB91_04815	COG1546	Belongs to the CinA family
HYB91_04860	COG0588	phosphoglycerate mutase activity
HYB91_04890	COG1131	(ABC) transporter
HYB91_04900	COG0457	Tetratricopeptide repeat
HYB91_04905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYB91_04910	COG2203	Gaf domain
HYB91_04910	COG3706	GGDEF domain
HYB91_04910	COG4251	negative regulation of phosphorylation
HYB91_04910	COG5001	Diguanylate cyclase
HYB91_04915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYB91_04920	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HYB91_04925	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HYB91_04930	COG1394	ATPase activity, coupled to movement of substances
HYB91_04935	COG1269	ATP hydrolysis coupled proton transport
HYB91_04945	COG0360	Binds together with S18 to 16S ribosomal RNA
HYB91_04950	COG0629	single-stranded DNA binding
HYB91_04955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYB91_04960	COG0359	binds to the 23S rRNA
HYB91_04970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYB91_04975	COG0740	serine-type endopeptidase activity
HYB91_04980	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYB91_05000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYB91_05010	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYB91_05030	COG0305	Participates in initiation and elongation during chromosome replication
HYB91_05045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYB91_05050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYB91_05055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYB91_05075	COG1132	(ABC) transporter
HYB91_05080	COG1132	(ABC) transporter
HYB91_05085	COG1268	BioY protein
HYB91_05090	COG1122	ATPase activity
HYB91_05115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYB91_05130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HYB91_05135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYB91_05145	COG0237	dephospho-CoA kinase activity
HYB91_05150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYB91_05150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYB91_05150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYB91_05170	COG3052	prosthetic group binding
HYB91_05200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYB91_05210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYB91_05215	COG0509	glycine decarboxylation via glycine cleavage system
HYB91_05220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYB91_05225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYB91_05230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYB91_05250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYB91_05300	COG0789	Transcriptional regulator
HYB91_05305	COG4221	oxidoreductase activity
HYB91_05330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYB91_05355	COG1129	ABC transporter
HYB91_05365	COG2375	cellular response to nickel ion
HYB91_05365	COG1132	(ABC) transporter
HYB91_05370	COG1132	(ABC) transporter
HYB91_05375	COG1129	ABC transporter
HYB91_05380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYB91_05390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYB91_05395	COG0493	'glutamate synthase
HYB91_05395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYB91_05405	COG0488	(ABC) transporter
HYB91_05410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYB91_05420	COG0835	chemotaxis
HYB91_05430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYB91_05450	COG0297	glycogen (starch) synthase activity
HYB91_05455	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HYB91_05460	COG2982	Protein involved in outer membrane biogenesis
HYB91_05480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_05485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYB91_05555	COG0095	Lipoate-protein ligase
HYB91_05560	COG0205	6-phosphofructokinase activity
HYB91_05565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYB91_05570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYB91_05575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYB91_05595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYB91_05610	COG0727	PFAM Uncharacterised protein family (UPF0153)
HYB91_05630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYB91_05635	COG0142	geranyltranstransferase activity
HYB91_05645	COG1692	metallophosphoesterase
HYB91_05665	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HYB91_05695	COG1136	(ABC) transporter
HYB91_05700	COG0577	efflux transmembrane transporter activity
HYB91_05700	COG1136	(ABC) transporter
HYB91_05715	COG3470	protein probably involved in high-affinity Fe2 transport
HYB91_05720	COG0672	)-iron permease
HYB91_05725	COG1136	(ABC) transporter
HYB91_05735	COG1760	l-serine dehydratase
HYB91_05740	COG1760	l-serine dehydratase
HYB91_05750	COG0254	rRNA binding
HYB91_05755	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYB91_05770	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_05770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_05780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYB91_05785	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYB91_05795	COG1196	nuclear chromosome segregation
HYB91_05805	COG2201	protein-glutamate methylesterase activity
HYB91_05815	COG0835	chemotaxis
HYB91_05835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYB91_05840	COG0217	transcriptional regulatory protein
HYB91_05890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYB91_05895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYB91_05905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYB91_05905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYB91_05920	COG0802	atpase or kinase
HYB91_05930	COG3437	response regulator, receiver
HYB91_05935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYB91_05945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYB91_05955	COG0009	L-threonylcarbamoyladenylate synthase
HYB91_05990	COG1136	(ABC) transporter
HYB91_06000	COG3850	Histidine kinase
HYB91_06000	COG5002	protein histidine kinase activity
HYB91_06005	COG0745	RESPONSE REGULATOR receiver
HYB91_06015	COG2190	(PTS) system
HYB91_06015	COG2211	Major facilitator Superfamily
HYB91_06030	COG1193	negative regulation of DNA recombination
HYB91_06035	COG1162	GTPase activity
HYB91_06045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYB91_06060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYB91_06070	COG0124	histidyl-tRNA synthetase
HYB91_06085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYB91_06090	COG0438	transferase activity, transferring glycosyl groups
HYB91_06100	COG0706	membrane insertase activity
HYB91_06105	COG1215	transferase activity, transferring glycosyl groups
HYB91_06105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYB91_06110	COG1216	Glycosyl transferase, family 2
HYB91_06110	COG1442	glycosyl transferase family 8
HYB91_06120	COG0438	transferase activity, transferring glycosyl groups
HYB91_06125	COG0463	Glycosyl transferase, family 2
HYB91_06130	COG0463	Glycosyl transferase, family 2
HYB91_06140	COG0438	transferase activity, transferring glycosyl groups
HYB91_06165	COG1215	transferase activity, transferring glycosyl groups
HYB91_06165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYB91_06170	COG1216	Glycosyl transferase, family 2
HYB91_06180	COG2423	ornithine cyclodeaminase activity
HYB91_06205	COG0028	Belongs to the TPP enzyme family
HYB91_06205	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HYB91_06215	COG0475	glutathione-regulated potassium exporter activity
HYB91_06240	COG1078	dGTPase activity
HYB91_06250	COG0047	phosphoribosylformylglycinamidine synthase activity
HYB91_06260	COG0488	(ABC) transporter
HYB91_06275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYB91_06275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYB91_06280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYB91_06315	COG4658	electron transport chain
HYB91_06320	COG4656	Part of a membrane complex involved in electron transport
HYB91_06335	COG0564	pseudouridine synthase activity
HYB91_06345	COG2217	Heavy metal translocating P-type atpase
HYB91_06350	COG0640	Transcriptional regulator
HYB91_06355	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HYB91_06390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYB91_06415	COG0557	exoribonuclease II activity
HYB91_06420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYB91_06420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYB91_06425	COG0556	nucleotide-excision repair
HYB91_06435	COG0346	lactoylglutathione lyase activity
HYB91_06440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_06450	COG0525	valine-tRNA ligase activity
HYB91_06465	COG2252	PERMEase
HYB91_06490	COG0772	Belongs to the SEDS family
HYB91_06495	COG0768	penicillin binding
HYB91_06510	COG1077	Cell shape determining protein MreB Mrl
HYB91_06530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_06535	COG0358	DNA primase activity
HYB91_06545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_06550	COG0457	Tetratricopeptide repeat
HYB91_06555	COG0037	tRNA processing
HYB91_06560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYB91_06570	COG2088	sporulation resulting in formation of a cellular spore
HYB91_06575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYB91_06600	COG0330	HflC and HflK could
HYB91_06605	COG0330	HflC and HflK could
HYB91_06615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYB91_06645	COG1739	Uncharacterized protein family UPF0029
HYB91_06670	COG2604	Protein of unknown function DUF115
HYB91_06675	COG0768	penicillin binding
HYB91_06685	COG0433	COG0433 Predicted ATPase
HYB91_06695	COG0312	modulator of DNA gyrase
HYB91_06700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYB91_06730	COG0497	DNA recombination
HYB91_06750	COG0791	NLP P60 protein
HYB91_06750	COG1388	LysM domain
HYB91_06760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYB91_06765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYB91_06770	COG0312	modulator of DNA gyrase
HYB91_06805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_06810	COG0840	transmembrane signaling receptor activity
HYB91_06850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYB91_06855	COG4475	Protein of unknown function (DUF436)
HYB91_06860	COG3421	Type III restriction
HYB91_06865	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HYB91_06885	COG0601	transmembrane transport
HYB91_06890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_06900	COG0444	Belongs to the ABC transporter superfamily
HYB91_06905	COG4608	Belongs to the ABC transporter superfamily
HYB91_06940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYB91_06945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYB91_06950	COG3118	belongs to the thioredoxin family
HYB91_06960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYB91_06965	COG4750	Nucleotidyl transferase
HYB91_06970	COG1115	amino acid carrier protein
HYB91_07000	COG1193	negative regulation of DNA recombination
HYB91_07065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYB91_07070	COG1480	7TM receptor with intracellular HD hydrolase
HYB91_07075	COG1702	phosphate starvation-inducible protein PhoH
HYB91_07090	COG0149	triose-phosphate isomerase activity
HYB91_07115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYB91_07130	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYB91_07135	COG1121	(ABC) transporter
HYB91_07140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_07145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_07170	COG1157	protein secretion by the type III secretion system
HYB91_07175	COG1317	bacterial-type flagellum organization
HYB91_07185	COG1766	The M ring may be actively involved in energy transduction
HYB91_07190	COG1677	Flagellar hook-basal body complex protein FliE
HYB91_07205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HYB91_07210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HYB91_07215	COG4974	Belongs to the 'phage' integrase family
HYB91_07220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYB91_07220	COG0551	DNA topoisomerase type I activity
HYB91_07225	COG0758	DNA mediated transformation
HYB91_07235	COG4974	Belongs to the 'phage' integrase family
HYB91_07240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYB91_07255	COG0772	Belongs to the SEDS family
HYB91_07260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYB91_07270	COG0275	rRNA processing
HYB91_07275	COG2001	Belongs to the MraZ family
HYB91_07280	COG1505	serine-type exopeptidase activity
HYB91_07320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYB91_07330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HYB91_07350	COG1120	ATPase activity
HYB91_07355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_07360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYB91_07365	COG1846	Transcriptional regulator
HYB91_07370	COG0500	methyltransferase
HYB91_07380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_07385	COG1120	ATPase activity
HYB91_07395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYB91_07400	COG0459	protein refolding
HYB91_07415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYB91_07425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYB91_07465	COG1366	Belongs to the anti-sigma-factor antagonist family
HYB91_07485	COG3033	Beta-eliminating lyase
HYB91_07510	COG0563	adenylate kinase activity
HYB91_07530	COG0779	Required for maturation of 30S ribosomal subunits
HYB91_07540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYB91_07545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYB91_07550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYB91_07590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYB91_07595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYB91_07605	COG3330	Domain of unknown function (DUF4912)
HYB91_07620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYB91_07630	COG3706	GGDEF domain
HYB91_07635	COG1102	Psort location Cytoplasmic, score
HYB91_07640	COG1561	YicC-like family, N-terminal region
HYB91_07655	COG0564	pseudouridine synthase activity
HYB91_07670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYB91_07675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYB91_07680	COG0426	domain, Protein
HYB91_07680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYB91_07690	COG4608	Belongs to the ABC transporter superfamily
HYB91_07695	COG0444	Belongs to the ABC transporter superfamily
HYB91_07700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_07720	COG0601	transmembrane transport
HYB91_07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_07730	COG0444	Belongs to the ABC transporter superfamily
HYB91_07735	COG4608	Belongs to the ABC transporter superfamily
HYB91_07745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYB91_07745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYB91_07785	COG0534	Mate efflux family protein
HYB91_07790	COG0840	transmembrane signaling receptor activity
HYB91_07815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_07820	COG0049	tRNA binding
HYB91_07825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYB91_07835	COG2832	Protein of unknown function (DUF454)
HYB91_07850	COG0756	dUTP diphosphatase activity
HYB91_07855	COG1185	polyribonucleotide nucleotidyltransferase activity
HYB91_07860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYB91_07865	COG0196	riboflavin kinase activity
HYB91_07890	COG0598	Magnesium transport protein CorA
HYB91_07895	COG0617	tRNA 3'-terminal CCA addition
HYB91_07910	COG0071	Belongs to the small heat shock protein (HSP20) family
HYB91_07915	COG0571	ribonuclease III activity
HYB91_07920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYB91_07925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYB91_07935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYB91_07955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYB91_07955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYB91_07970	COG1067	ATP-dependent peptidase activity
HYB91_07980	COG2703	oxygen carrier activity
HYB91_07985	COG2183	response to ionizing radiation
HYB91_07995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYB91_08005	COG3951	Flagellar rod assembly protein muramidase FlgJ
HYB91_08015	COG4786	Flagellar basal body rod
HYB91_08035	COG2084	Dehydrogenase
HYB91_08040	COG2116	formate transmembrane transporter activity
HYB91_08050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYB91_08070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYB91_08080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYB91_08085	COG4166	transmembrane transport
HYB91_08090	COG4608	Belongs to the ABC transporter superfamily
HYB91_08095	COG0444	Belongs to the ABC transporter superfamily
HYB91_08100	COG4166	transmembrane transport
HYB91_08105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_08110	COG4174	ABC transporter (Permease)
HYB91_08115	COG4166	transmembrane transport
HYB91_08130	COG0017	Asparaginyl-tRNA synthetase
HYB91_08135	COG1686	Belongs to the peptidase S11 family
HYB91_08140	COG2003	Belongs to the UPF0758 family
HYB91_08145	COG1040	competence protein
HYB91_08150	COG0018	arginyl-trna synthetase
HYB91_08165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYB91_08175	COG0084	hydrolase, TatD family'
HYB91_08180	COG1692	metallophosphoesterase
HYB91_08190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYB91_08200	COG0484	heat shock protein binding
HYB91_08205	COG2089	acid synthase
HYB91_08210	COG5341	Protein conserved in bacteria
HYB91_08215	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYB91_08220	COG0584	glycerophosphoryl diester phosphodiesterase
HYB91_08225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYB91_08230	COG1704	LemA family
HYB91_08235	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYB91_08240	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYB91_08245	COG3845	ABC transporter
HYB91_08250	COG1744	ABC transporter substrate-binding protein PnrA-like
HYB91_08260	COG0148	phosphopyruvate hydratase activity
HYB91_08275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_08290	COG0318	PFAM AMP-dependent synthetase and ligase
HYB91_08295	COG0791	NLP P60 protein
HYB91_08305	COG3735	TraB family
HYB91_08310	COG0116	Belongs to the methyltransferase superfamily
HYB91_08315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_08320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYB91_08325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYB91_08335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYB91_08340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYB91_08345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HYB91_08360	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYB91_08365	COG2375	cellular response to nickel ion
HYB91_08365	COG1132	(ABC) transporter
HYB91_08370	COG1132	(ABC) transporter
HYB91_08375	COG1132	(ABC) transporter
HYB91_08380	COG1132	(ABC) transporter
HYB91_08390	COG0433	COG0433 Predicted ATPase
HYB91_08410	COG1132	(ABC) transporter
HYB91_08425	COG1132	(ABC) transporter
HYB91_08450	COG1129	ABC transporter
HYB91_08460	COG0210	DNA helicase
HYB91_08475	COG1129	ABC transporter
HYB91_08490	COG1132	(ABC) transporter
HYB91_08495	COG2375	cellular response to nickel ion
HYB91_08495	COG1132	(ABC) transporter
HYB91_08500	COG2207	Transcriptional regulator
HYB91_08510	COG4555	ABC transporter
HYB91_08520	COG2378	regulation of single-species biofilm formation
HYB91_08540	COG0335	large ribosomal subunit rRNA binding
HYB91_08545	COG0336	Belongs to the RNA methyltransferase TrmD family
HYB91_08550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYB91_08555	COG1837	Belongs to the UPF0109 family
HYB91_08560	COG0228	four-way junction DNA binding
HYB91_08590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYB91_08595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYB91_08600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYB91_08605	COG0737	Belongs to the 5'-nucleotidase family
HYB91_08635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYB91_08640	COG1285	pathogenesis
HYB91_08660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYB91_08665	COG1187	pseudouridine synthase activity
HYB91_08690	COG2197	response regulator
HYB91_08695	COG2137	regulation of response to DNA damage stimulus
HYB91_08705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYB91_08730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYB91_08740	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_08740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_08755	COG2304	oxidoreductase activity
HYB91_08765	COG1054	Belongs to the UPF0176 family
HYB91_08770	COG4656	Part of a membrane complex involved in electron transport
HYB91_08775	COG4658	electron transport chain
HYB91_08780	COG4659	FMN binding
HYB91_08785	COG4660	Part of a membrane complex involved in electron transport
HYB91_08790	COG4657	Part of a membrane complex involved in electron transport
HYB91_08795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYB91_08810	COG1362	aminopeptidase activity
HYB91_08815	COG0445	tRNA wobble uridine modification
HYB91_08820	COG3422	double-strand break repair
HYB91_08825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYB91_08830	COG2340	Cysteine-rich secretory protein family
HYB91_08835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYB91_08850	COG1132	(ABC) transporter
HYB91_08860	COG2274	protein secretion by the type I secretion system
HYB91_08930	COG1690	Belongs to the RtcB family
HYB91_08940	COG2910	NAD(P)H-binding
HYB91_08945	COG1959	2 iron, 2 sulfur cluster binding
HYB91_08955	COG0584	glycerophosphoryl diester phosphodiesterase
HYB91_08965	COG1254	Belongs to the acylphosphatase family
HYB91_08990	COG0203	ribosomal protein L17
HYB91_08995	COG0202	RNA polymerase activity
HYB91_09000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYB91_09005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYB91_09010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYB91_09020	COG0200	Binds to the 23S rRNA
HYB91_09025	COG1841	ribosomal large subunit assembly
HYB91_09030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYB91_09035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYB91_09040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYB91_09045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYB91_09050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYB91_09055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYB91_09060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYB91_09065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYB91_09070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYB91_09075	COG0255	Belongs to the universal ribosomal protein uL29 family
HYB91_09080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYB91_09085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYB91_09090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYB91_09095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYB91_09100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYB91_09105	COG0089	rRNA binding
HYB91_09110	COG0088	Forms part of the polypeptide exit tunnel
HYB91_09115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYB91_09120	COG0051	transcription antitermination factor activity, RNA binding
HYB91_09125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYB91_09155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_09160	COG1120	ATPase activity
HYB91_09165	COG1757	Na H antiporter
HYB91_09180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_09190	COG3118	belongs to the thioredoxin family
HYB91_09240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYB91_09260	COG1086	Polysaccharide biosynthesis protein
HYB91_09300	COG0330	HflC and HflK could
HYB91_09315	COG1131	(ABC) transporter
HYB91_09355	COG1131	(ABC) transporter
HYB91_09360	COG0351	phosphomethylpyrimidine kinase
HYB91_09370	COG0482	sulfurtransferase activity
HYB91_09385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYB91_09390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYB91_09395	COG1028	Short-chain dehydrogenase reductase Sdr
HYB91_09400	COG0629	single-stranded DNA binding
HYB91_09405	COG1862	Preprotein translocase
HYB91_09410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYB91_09415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYB91_09420	COG1104	cysteine desulfurase activity
HYB91_09430	COG0425	Belongs to the sulfur carrier protein TusA family
HYB91_09475	COG0484	heat shock protein binding
HYB91_09490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYB91_09500	COG0719	Fe-S assembly protein
HYB91_09505	COG0396	ATPase activity
HYB91_09510	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYB91_09510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYB91_09510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HYB91_09510	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYB91_09515	COG2885	chlorophyll binding
HYB91_09525	COG4115	mRNA cleavage
HYB91_09550	COG2378	regulation of single-species biofilm formation
HYB91_09565	COG1136	(ABC) transporter
HYB91_09570	COG5002	protein histidine kinase activity
HYB91_09580	COG1473	amidohydrolase
HYB91_09595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYB91_09615	COG2201	protein-glutamate methylesterase activity
HYB91_09635	COG1137	ATPase activity
HYB91_09640	COG0193	aminoacyl-tRNA hydrolase activity
HYB91_09650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYB91_09660	COG0601	transmembrane transport
HYB91_09665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_09670	COG0444	Belongs to the ABC transporter superfamily
HYB91_09675	COG4608	Belongs to the ABC transporter superfamily
HYB91_09685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYB91_09710	COG0484	heat shock protein binding
HYB91_09715	COG0443	Heat shock 70 kDa protein
HYB91_09720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYB91_09745	COG1120	ATPase activity
HYB91_09770	COG0534	Mate efflux family protein
HYB91_09800	COG1192	Involved in chromosome partitioning
HYB91_09805	COG1475	DNA binding
HYB91_09825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYB91_09830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYB91_09835	COG1028	Short-chain dehydrogenase reductase Sdr
HYB91_09850	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYB91_09880	COG0439	Biotin carboxylase
HYB91_09885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYB91_09890	COG0825	malonyl-CoA metabolic process
HYB91_09895	COG2986	histidine ammonia-lyase
HYB91_09910	COG0701	Predicted permease
HYB91_09915	COG3689	TIGRFAM TIGR03943 family protein
HYB91_09920	COG0714	Associated with various cellular activities
HYB91_09955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYB91_09960	COG0154	amidase activity
HYB91_09965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYB91_10135	COG1136	(ABC) transporter
HYB91_10290	COG3041	Addiction module toxin RelE StbE family
HYB91_10335	COG1396	sequence-specific DNA binding
HYB91_10345	COG3550	peptidyl-serine autophosphorylation
HYB91_10365	COG4555	ABC transporter
HYB91_10405	COG1151	hydroxylamine reductase activity
HYB91_10420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYB91_10425	COG0577	efflux transmembrane transporter activity
HYB91_10425	COG1136	(ABC) transporter
HYB91_10480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYB91_10515	COG0813	purine-nucleoside phosphorylase activity
HYB91_10535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HYB91_10540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_10550	COG2235	arginine
HYB91_10555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYB91_10565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYB91_10585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HYB91_10620	COG0343	queuine tRNA-ribosyltransferase activity
HYB91_10630	COG1381	Involved in DNA repair and RecF pathway recombination
HYB91_10640	COG0514	ATP-dependent DNA helicase (RecQ)
HYB91_10645	COG1592	Rubrerythrin
HYB91_10710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYB91_10715	COG0501	Belongs to the peptidase M48B family
HYB91_10725	COG0543	2 iron, 2 sulfur cluster binding
HYB91_10755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYB91_10770	COG0747	negative chemotaxis
HYB91_10775	COG4608	Belongs to the ABC transporter superfamily
HYB91_10780	COG0444	Belongs to the ABC transporter superfamily
HYB91_10785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_10800	COG1840	ABC-type Fe3 transport system, periplasmic component
HYB91_10845	COG3842	ATPase activity
HYB91_10850	COG0438	transferase activity, transferring glycosyl groups
HYB91_10860	COG2274	protein secretion by the type I secretion system
HYB91_10860	COG3271	cysteine-type peptidase activity
HYB91_10880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYB91_10890	COG0786	glutamate:sodium symporter activity
HYB91_10895	COG1132	(ABC) transporter
HYB91_10900	COG1132	(ABC) transporter
HYB91_10920	COG0583	DNA-binding transcription factor activity
HYB91_10925	COG0656	L-ascorbic acid biosynthetic process
HYB91_10970	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYB91_10985	COG0698	ribose 5-phosphate isomerase
HYB91_10990	COG0039	L-malate dehydrogenase activity
HYB91_10995	COG0534	Mate efflux family protein
HYB91_11000	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_11000	COG3848	Pyruvate phosphate dikinase
HYB91_11005	COG1309	transcriptional regulator
HYB91_11010	COG0840	transmembrane signaling receptor activity
HYB91_11030	COG0728	peptidoglycan biosynthetic process
HYB91_11035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYB91_11040	COG3588	fructose-bisphosphate aldolase
HYB91_11045	COG1309	transcriptional regulator
HYB91_11060	COG0363	glucosamine-6-phosphate deaminase activity
HYB91_11065	COG0628	permease
HYB91_11070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYB91_11080	COG0534	Mate efflux family protein
HYB91_11085	COG1309	transcriptional regulator
HYB91_11095	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYB91_11100	COG1518	maintenance of DNA repeat elements
HYB91_11105	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HYB91_11110	COG0514	ATP-dependent DNA helicase (RecQ)
HYB91_11135	COG4536	flavin adenine dinucleotide binding
HYB91_11140	COG4536	flavin adenine dinucleotide binding
HYB91_11145	COG0714	Associated with various cellular activities
HYB91_11160	COG0569	domain protein
HYB91_11165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYB91_11170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYB91_11200	COG0616	signal peptide processing
HYB91_11205	COG0012	GTP binding
HYB91_11230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYB91_11240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYB91_11245	COG0569	domain protein
HYB91_11255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HYB91_11280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_11295	COG1129	ABC transporter
HYB91_11310	COG0596	Alpha beta hydrolase
HYB91_11340	COG2375	cellular response to nickel ion
HYB91_11340	COG1132	(ABC) transporter
HYB91_11345	COG1132	(ABC) transporter
HYB91_11395	COG1846	Transcriptional regulator
HYB91_11400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYB91_11415	COG1129	ABC transporter
HYB91_11430	COG0733	neurotransmitter:sodium symporter activity
HYB91_11440	COG3189	MarR family transcriptional regulator
HYB91_11445	COG1309	transcriptional regulator
HYB91_11450	COG1132	(ABC) transporter
HYB91_11455	COG1132	(ABC) transporter
HYB91_11460	COG1129	ABC transporter
HYB91_11480	COG1129	ABC transporter
HYB91_11495	COG1132	(ABC) transporter
HYB91_11500	COG1132	(ABC) transporter
HYB91_11500	COG2375	cellular response to nickel ion
HYB91_11535	COG1418	mRNA catabolic process
HYB91_11555	COG3177	Filamentation induced by cAMP protein fic
HYB91_11560	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HYB91_11565	COG0592	DNA-directed DNA polymerase activity
HYB91_11570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYB91_11620	COG0477	Major facilitator Superfamily
HYB91_11625	COG1473	amidohydrolase
HYB91_11680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYB91_11695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYB91_11700	COG1929	Belongs to the glycerate kinase type-1 family
HYB91_11705	COG2610	gluconate transmembrane transporter activity
HYB91_11945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYB91_11960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYB91_12015	COG2184	nucleotidyltransferase activity
HYB91_12025	COG0730	response to heat
HYB91_12045	COG4208	sulfate ABC transporter
HYB91_12060	COG0840	transmembrane signaling receptor activity
HYB91_12075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYB91_12085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYB91_12090	COG1674	ftsk spoiiie
HYB91_12095	COG1968	undecaprenyl-diphosphatase activity
HYB91_12100	COG0419	ATPase involved in DNA repair
HYB91_12105	COG0420	3'-5' exonuclease activity
HYB91_12110	COG0840	transmembrane signaling receptor activity
HYB91_12110	COG3290	protein histidine kinase activity
HYB91_12120	COG1131	(ABC) transporter
HYB91_12140	COG0716	FMN binding
HYB91_12175	COG0800	Aldolase
HYB91_12225	COG4585	Histidine kinase
HYB91_12230	COG1473	amidohydrolase
HYB91_12240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HYB91_12245	COG4143	(ABC) transporter
HYB91_12255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYB91_12260	COG1070	Carbohydrate kinase
HYB91_12270	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYB91_12280	COG2186	Transcriptional regulator
HYB91_12290	COG1823	symporter activity
HYB91_12295	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HYB91_12295	COG0540	Belongs to the ATCase OTCase family
HYB91_12300	COG5002	protein histidine kinase activity
HYB91_12300	COG5001	Diguanylate cyclase
HYB91_12360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HYB91_12375	COG1774	PSP1 C-terminal conserved region
HYB91_12380	COG1728	Protein conserved in bacteria
HYB91_12390	COG0739	heme binding
HYB91_12405	COG0366	Alpha amylase catalytic
HYB91_12415	COG1609	Transcriptional regulator
HYB91_12440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYB91_12445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYB91_12450	COG1104	cysteine desulfurase activity
HYB91_12465	COG0823	Involved in the tonB-independent uptake of proteins
HYB91_12465	COG1506	peptidase
HYB91_12465	COG4946	Tricorn protease homolog
HYB91_12495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYB91_12500	COG0215	cysteine-tRNA ligase activity
HYB91_12515	COG1305	Transglutaminase-like
HYB91_12520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYB91_12525	COG0569	domain protein
HYB91_12530	COG2887	Belongs to the helicase family. UvrD subfamily
HYB91_12535	COG1074	ATP-dependent DNA helicase activity
HYB91_12540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_12560	COG0840	transmembrane signaling receptor activity
HYB91_12565	COG0826	peptidase U32
HYB91_12570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_12575	COG1509	lysine 2,3-aminomutase activity
HYB91_12580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYB91_12585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYB91_12600	COG0205	6-phosphofructokinase activity
HYB91_12630	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYB91_12640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYB91_12645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYB91_12650	COG1684	flagellar biosynthetic protein fliR
HYB91_12655	COG1987	bacterial-type flagellum assembly
HYB91_12680	COG1228	amidohydrolase
HYB91_12695	COG0457	Tetratricopeptide repeat
HYB91_12700	COG0280	phosphate acetyltransferase
HYB91_12710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYB91_12715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYB91_12730	COG0537	adenosine 5'-monophosphoramidase activity
HYB91_12765	COG1132	(ABC) transporter
HYB91_12795	COG1472	Belongs to the glycosyl hydrolase 3 family
HYB91_12815	COG0423	glycine-tRNA ligase activity
HYB91_12820	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYB91_12830	COG1363	Peptidase, m42
HYB91_12835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYB91_12850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYB91_12855	COG1966	Carbon starvation protein
HYB91_12860	COG0450	alkyl hydroperoxide reductase
HYB91_12865	COG0494	nUDIX hydrolase
HYB91_12885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYB91_12905	COG0187	DNA topoisomerase II activity