locus-tag	class	description
E4O00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O00_00045	COG0840	transmembrane signaling receptor activity
E4O00_00050	COG1132	(ABC) transporter
E4O00_00065	COG1132	(ABC) transporter
E4O00_00095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O00_00100	COG1120	ATPase activity
E4O00_00105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4O00_00130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4O00_00135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4O00_00140	COG2986	histidine ammonia-lyase
E4O00_00185	COG4166	transmembrane transport
E4O00_00190	COG0739	heme binding
E4O00_00195	COG4545	Glutaredoxin-related protein
E4O00_00235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O00_00245	COG0732	type I restriction modification DNA specificity domain
E4O00_00250	COG4974	Belongs to the 'phage' integrase family
E4O00_00260	COG0732	type I restriction modification DNA specificity domain
E4O00_00290	COG3116	cell division
E4O00_00290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O00_00295	COG0084	hydrolase, TatD family'
E4O00_00310	COG2199	diguanylate cyclase activity
E4O00_00310	COG2203	Gaf domain
E4O00_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O00_00325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O00_00340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O00_00350	COG2239	Acts as a magnesium transporter
E4O00_00360	COG0546	phosphoglycolate phosphatase activity
E4O00_00365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O00_00385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O00_00400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O00_00405	COG1360	Flagellar Motor Protein
E4O00_00410	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O00_00415	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O00_00420	COG1776	CheC inhibitor of MCP methylation
E4O00_00420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O00_00430	COG1338	Plays a role in the flagellum-specific transport system
E4O00_00470	COG2211	Major facilitator Superfamily
E4O00_00480	COG0396	ATPase activity
E4O00_00485	COG0719	Fe-S assembly protein
E4O00_00495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O00_00540	COG5433	transposase activity
E4O00_00555	COG1104	cysteine desulfurase activity
E4O00_00560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O00_00565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O00_00570	COG1862	Preprotein translocase
E4O00_00575	COG5433	transposase activity
E4O00_00580	COG0629	single-stranded DNA binding
E4O00_00585	COG0300	oxidoreductase activity
E4O00_00590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O00_00595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O00_00610	COG0482	sulfurtransferase activity
E4O00_00615	COG0351	phosphomethylpyrimidine kinase
E4O00_00620	COG1131	(ABC) transporter
E4O00_00645	COG0330	HflC and HflK could
E4O00_00660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O00_00675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O00_00680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O00_00685	COG1477	protein flavinylation
E4O00_00705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O00_00720	COG0840	transmembrane signaling receptor activity
E4O00_00725	COG0840	transmembrane signaling receptor activity
E4O00_00730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O00_00735	COG3314	Sporulation integral membrane protein YlbJ
E4O00_00745	COG2264	protein methyltransferase activity
E4O00_00750	COG0346	lactoylglutathione lyase activity
E4O00_00765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O00_00785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O00_00795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O00_00820	COG0724	RNA recognition motif
E4O00_00825	COG1054	Belongs to the UPF0176 family
E4O00_00830	COG1362	aminopeptidase activity
E4O00_00865	COG3706	GGDEF domain
E4O00_00895	COG0564	pseudouridine synthase activity
E4O00_00905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O00_00915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O00_00920	COG4443	Transcriptional Coactivator p15 (PC4)
E4O00_00930	COG0328	RNA-DNA hybrid ribonuclease activity
E4O00_00940	COG0301	tRNA thio-modification
E4O00_00960	COG4115	mRNA cleavage
E4O00_00970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O00_00995	COG1132	(ABC) transporter
E4O00_01030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O00_01035	COG0445	tRNA wobble uridine modification
E4O00_01040	COG1362	aminopeptidase activity
E4O00_01055	COG4660	Part of a membrane complex involved in electron transport
E4O00_01060	COG4659	FMN binding
E4O00_01065	COG4658	electron transport chain
E4O00_01070	COG4656	Part of a membrane complex involved in electron transport
E4O00_01075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4O00_01085	COG2304	oxidoreductase activity
E4O00_01110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O00_01125	COG0840	transmembrane signaling receptor activity
E4O00_01140	COG3290	protein histidine kinase activity
E4O00_01140	COG0840	transmembrane signaling receptor activity
E4O00_01150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O00_01165	COG2197	response regulator
E4O00_01170	COG0235	Class ii aldolase
E4O00_01190	COG1187	pseudouridine synthase activity
E4O00_01195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O00_01215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O00_01240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O00_01245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O00_01250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O00_01270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4O00_01290	COG0228	four-way junction DNA binding
E4O00_01295	COG1837	Belongs to the UPF0109 family
E4O00_01300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O00_01305	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O00_01310	COG0335	large ribosomal subunit rRNA binding
E4O00_01355	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O00_01360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O00_01365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O00_01370	COG0534	Mate efflux family protein
E4O00_01380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O00_01385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O00_01390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O00_01395	COG0116	Belongs to the methyltransferase superfamily
E4O00_01400	COG3735	TraB family
E4O00_01415	COG0318	PFAM AMP-dependent synthetase and ligase
E4O00_01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O00_01455	COG0148	phosphopyruvate hydratase activity
E4O00_01510	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O00_01515	COG3845	ABC transporter
E4O00_01520	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O00_01525	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O00_01530	COG1704	LemA family
E4O00_01535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4O00_01550	COG5341	Protein conserved in bacteria
E4O00_01555	COG2089	acid synthase
E4O00_01570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O00_01580	COG1692	metallophosphoesterase
E4O00_01595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O00_01600	COG0018	arginyl-trna synthetase
E4O00_01605	COG1040	competence protein
E4O00_01610	COG2003	Belongs to the UPF0758 family
E4O00_01620	COG1686	Belongs to the peptidase S11 family
E4O00_01625	COG0017	Asparaginyl-tRNA synthetase
E4O00_01640	COG4174	ABC transporter (Permease)
E4O00_01645	COG4239	(ABC) transporter, permease
E4O00_01650	COG4166	transmembrane transport
E4O00_01655	COG0444	Belongs to the ABC transporter superfamily
E4O00_01660	COG4608	Belongs to the ABC transporter superfamily
E4O00_01665	COG4166	transmembrane transport
E4O00_01670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O00_01680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O00_01700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4O00_01705	COG2116	formate transmembrane transporter activity
E4O00_01710	COG2084	Dehydrogenase
E4O00_01725	COG4786	Flagellar basal body rod
E4O00_01735	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O00_01745	COG0210	DNA helicase
E4O00_01785	COG2949	membrane
E4O00_01790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O00_01845	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E4O00_01865	COG0668	transmembrane transport
E4O00_01890	COG1196	nuclear chromosome segregation
E4O00_01890	COG0741	lytic transglycosylase activity
E4O00_01890	COG0739	heme binding
E4O00_01935	COG1272	protein, Hemolysin III
E4O00_01960	COG3604	Transcriptional regulator
E4O00_01990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O00_02005	COG0792	nuclease activity
E4O00_02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O00_02025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O00_02030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O00_02045	COG0668	transmembrane transport
E4O00_02060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O00_02065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O00_02065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O00_02075	COG5433	transposase activity
E4O00_02080	COG5433	transposase activity
E4O00_02095	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O00_02100	COG3956	TIGRFAM MazG family protein
E4O00_02165	COG1136	(ABC) transporter
E4O00_02170	COG1136	(ABC) transporter
E4O00_02170	COG0577	efflux transmembrane transporter activity
E4O00_02190	COG1639	'signal transduction protein
E4O00_02195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O00_02205	COG0101	tRNA pseudouridine synthase activity
E4O00_02220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O00_02225	COG1132	(ABC) transporter
E4O00_02240	COG0737	Belongs to the 5'-nucleotidase family
E4O00_02275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O00_02290	COG3142	Participates in the control of copper homeostasis
E4O00_02300	COG4865	methylaspartate mutase activity
E4O00_02315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O00_02330	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O00_02345	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O00_02365	COG0442	prolyl-tRNA aminoacylation
E4O00_02385	COG1879	ABC-type sugar transport system periplasmic component
E4O00_02425	COG2801	Transposase and inactivated derivatives
E4O00_02435	COG1129	ABC transporter
E4O00_02440	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O00_02445	COG2226	methyltransferase
E4O00_02475	COG2056	Na+-H+ antiporter family
E4O00_02480	COG1757	Na H antiporter
E4O00_02490	COG0626	cystathionine gamma-synthase activity
E4O00_02495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O00_02500	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O00_02500	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O00_02500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O00_02500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O00_02535	COG0156	8-amino-7-oxononanoate synthase activity
E4O00_02545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O00_02560	COG0739	heme binding
E4O00_02570	COG1475	DNA binding
E4O00_02575	COG1022	Amp-dependent synthetase and ligase
E4O00_02605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O00_02640	COG0640	Transcriptional regulator
E4O00_02645	COG0701	Predicted permease
E4O00_02660	COG0798	PFAM Bile acid sodium symporter
E4O00_02670	COG2226	methyltransferase
E4O00_02685	COG2738	Putative neutral zinc metallopeptidase
E4O00_02695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O00_02710	COG1129	ABC transporter
E4O00_02725	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O00_02730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O00_02740	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O00_02745	COG1671	Belongs to the UPF0178 family
E4O00_02755	COG0741	lytic transglycosylase activity
E4O00_02755	COG1388	LysM domain
E4O00_02780	COG3681	Belongs to the UPF0597 family
E4O00_02800	COG1770	oligopeptidase
E4O00_02830	COG1122	ATPase activity
E4O00_02850	COG1487	ribonuclease activity
E4O00_02890	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O00_02950	COG1131	(ABC) transporter
E4O00_02975	COG0513	Belongs to the DEAD box helicase family
E4O00_02985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O00_03010	COG3876	Protein conserved in bacteria
E4O00_03015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O00_03035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O00_03040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O00_03045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O00_03050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O00_03055	COG0484	heat shock protein binding
E4O00_03060	COG0528	UMP kinase activity
E4O00_03065	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O00_03080	COG0539	negative regulation of cytoplasmic translation
E4O00_03085	COG2204	response regulator
E4O00_03090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O00_03105	COG5001	Diguanylate cyclase
E4O00_03110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O00_03135	COG0251	oxidation-reduction process
E4O00_03140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O00_03145	COG1722	exodeoxyribonuclease VII activity
E4O00_03165	COG1918	ferrous iron import across plasma membrane
E4O00_03170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O00_03170	COG1918	ferrous iron import across plasma membrane
E4O00_03215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O00_03220	COG5433	transposase activity
E4O00_03255	COG3561	AntA/AntB antirepressor
E4O00_03295	COG0629	single-stranded DNA binding
E4O00_03305	COG1475	DNA binding
E4O00_03420	COG0740	serine-type endopeptidase activity
E4O00_03560	COG5433	transposase activity
E4O00_03575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4O00_03590	COG0552	protein localization to endoplasmic reticulum
E4O00_03600	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O00_03605	COG1136	(ABC) transporter
E4O00_03615	COG3880	PFAM UvrB UvrC protein
E4O00_03620	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O00_03630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O00_03640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O00_03650	COG0084	hydrolase, TatD family'
E4O00_03655	COG2885	chlorophyll binding
E4O00_03855	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O00_03865	COG1288	antiporter activity
E4O00_03910	COG1562	ergosterol biosynthetic process
E4O00_03920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O00_03925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O00_03935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4O00_03960	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O00_03995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4O00_04035	COG0542	response to heat
E4O00_04090	COG2885	chlorophyll binding
E4O00_04165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O00_04185	COG0470	DNA polymerase III
E4O00_04190	COG3852	Histidine kinase
E4O00_04195	COG2204	response regulator
E4O00_04200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O00_04215	COG0475	glutathione-regulated potassium exporter activity
E4O00_04220	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O00_04240	COG1598	PFAM Uncharacterised protein family UPF0150
E4O00_04280	COG1234	tRNA 3'-trailer cleavage
E4O00_04285	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O00_04295	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O00_04300	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O00_04330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O00_04350	COG2378	regulation of single-species biofilm formation
E4O00_04360	COG4555	ABC transporter
E4O00_04410	COG1136	(ABC) transporter
E4O00_04415	COG0556	nucleotide-excision repair
E4O00_04420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O00_04420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O00_04425	COG0557	exoribonuclease II activity
E4O00_04465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O00_04490	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O00_04495	COG0640	Transcriptional regulator
E4O00_04515	COG0564	pseudouridine synthase activity
E4O00_04530	COG4656	Part of a membrane complex involved in electron transport
E4O00_04575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O00_04580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O00_04580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O00_04595	COG0488	(ABC) transporter
E4O00_04605	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O00_04615	COG1078	dGTPase activity
E4O00_04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4O00_04760	COG1216	Glycosyl transferase, family 2
E4O00_04770	COG1215	transferase activity, transferring glycosyl groups
E4O00_04775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O00_04790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O00_04805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O00_04815	COG1162	GTPase activity
E4O00_04820	COG1193	negative regulation of DNA recombination
E4O00_04835	COG2190	(PTS) system
E4O00_04835	COG2211	Major facilitator Superfamily
E4O00_04855	COG0745	RESPONSE REGULATOR receiver
E4O00_04860	COG0745	RESPONSE REGULATOR receiver
E4O00_04860	COG2205	protein histidine kinase activity
E4O00_04860	COG3292	Two component regulator propeller
E4O00_04870	COG1136	(ABC) transporter
E4O00_04920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O00_04930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O00_04935	COG2770	Histidine kinase
E4O00_04935	COG3437	response regulator, receiver
E4O00_04945	COG0802	atpase or kinase
E4O00_04960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O00_04960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O00_04970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O00_04975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O00_05010	COG0217	transcriptional regulatory protein
E4O00_05015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O00_05030	COG5433	transposase activity
E4O00_05035	COG0643	Histidine kinase
E4O00_05035	COG2198	Histidine kinase
E4O00_05040	COG0835	chemotaxis
E4O00_05050	COG2201	protein-glutamate methylesterase activity
E4O00_05060	COG1196	nuclear chromosome segregation
E4O00_05070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O00_05130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O00_05140	COG0574	Belongs to the PEP-utilizing enzyme family
E4O00_05140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O00_05155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O00_05160	COG0254	rRNA binding
E4O00_05170	COG1760	l-serine dehydratase
E4O00_05175	COG1760	l-serine dehydratase
E4O00_05195	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O00_05275	COG0142	geranyltranstransferase activity
E4O00_05305	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O00_05320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O00_05340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O00_05345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O00_05350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O00_05360	COG0747	negative chemotaxis
E4O00_05365	COG0601	transmembrane transport
E4O00_05370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O00_05375	COG0444	Belongs to the ABC transporter superfamily
E4O00_05380	COG4608	Belongs to the ABC transporter superfamily
E4O00_05385	COG0095	Lipoate-protein ligase
E4O00_05390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O00_05395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O00_05425	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O00_05430	COG0297	glycogen (starch) synthase activity
E4O00_05455	COG0835	chemotaxis
E4O00_05480	COG0493	'glutamate synthase
E4O00_05480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O00_05485	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O00_05535	COG1051	belongs to the nudix hydrolase family
E4O00_05545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O00_05565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O00_05595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O00_05600	COG0509	glycine decarboxylation via glycine cleavage system
E4O00_05605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O00_05640	COG3052	prosthetic group binding
E4O00_05650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O00_05650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O00_05650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O00_05655	COG0237	dephospho-CoA kinase activity
E4O00_05665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O00_05670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O00_05685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O00_05705	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4O00_05710	COG1122	ATPase activity
E4O00_05715	COG1268	BioY protein
E4O00_05740	COG2801	Transposase and inactivated derivatives
E4O00_05760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O00_05765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O00_05770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O00_05800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O00_05810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O00_05830	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O00_05835	COG0740	serine-type endopeptidase activity
E4O00_05840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O00_05850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O00_05855	COG0629	single-stranded DNA binding
E4O00_05860	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O00_05870	COG1269	ATP hydrolysis coupled proton transport
E4O00_05875	COG1394	ATPase activity, coupled to movement of substances
E4O00_05880	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O00_05885	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O00_05890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O00_05900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O00_05905	COG0457	Tetratricopeptide repeat
E4O00_05915	COG1131	(ABC) transporter
E4O00_05940	COG0588	phosphoglycerate mutase activity
E4O00_05960	COG1546	Belongs to the CinA family
E4O00_05960	COG1058	Belongs to the CinA family
E4O00_05970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O00_05980	COG0268	Binds directly to 16S ribosomal RNA
E4O00_06000	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4O00_06005	COG0126	phosphoglycerate kinase activity
E4O00_06015	COG0519	Catalyzes the synthesis of GMP from XMP
E4O00_06025	COG0617	tRNA 3'-terminal CCA addition
E4O00_06045	COG0484	heat shock protein binding
E4O00_06050	COG0024	Methionine aminopeptidase
E4O00_06055	COG0708	Exodeoxyribonuclease III
E4O00_06065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O00_06075	COG0739	heme binding
E4O00_06115	COG2059	Chromate
E4O00_06120	COG0799	negative regulation of ribosome biogenesis
E4O00_06135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O00_06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O00_06150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O00_06155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O00_06160	COG2033	superoxide reductase activity
E4O00_06175	COG3093	addiction module antidote protein HigA
E4O00_06265	COG2801	Transposase and inactivated derivatives
E4O00_06285	COG5433	transposase activity
E4O00_06375	COG2226	methyltransferase
E4O00_06595	COG1136	(ABC) transporter
E4O00_06615	COG2056	Na+-H+ antiporter family
E4O00_06650	COG0632	four-way junction helicase activity
E4O00_06655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O00_06685	COG0793	Belongs to the peptidase S41A family
E4O00_06695	COG0488	(ABC) transporter
E4O00_06715	COG2723	6-phospho-beta-galactosidase activity
E4O00_06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O00_06745	COG1114	Component of the transport system for branched-chain amino acids
E4O00_06750	COG0481	GTPase activity
E4O00_06755	COG2878	Part of a membrane complex involved in electron transport
E4O00_06760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O00_06765	COG0138	bifunctional purine biosynthesis protein purh
E4O00_06770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O00_06775	COG0653	protein targeting
E4O00_06780	COG1725	Transcriptional regulator
E4O00_06800	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O00_06815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O00_06820	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O00_06835	COG1979	alcohol dehydrogenase
E4O00_06840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O00_06855	COG0731	radical SAM domain protein
E4O00_06870	COG1047	Peptidyl-prolyl cis-trans
E4O00_06900	COG0295	cytidine deaminase activity
E4O00_06910	COG2252	PERMEase
E4O00_06920	COG2017	converts alpha-aldose to the beta-anomer
E4O00_06945	COG0772	Belongs to the SEDS family
E4O00_06950	COG0768	penicillin binding
E4O00_06965	COG1077	Cell shape determining protein MreB Mrl
E4O00_06985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O00_06990	COG0358	DNA primase activity
E4O00_07010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O00_07015	COG0457	Tetratricopeptide repeat
E4O00_07020	COG0037	tRNA processing
E4O00_07025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O00_07035	COG2088	sporulation resulting in formation of a cellular spore
E4O00_07040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O00_07060	COG0330	HflC and HflK could
E4O00_07065	COG0330	HflC and HflK could
E4O00_07075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O00_07100	COG1739	Uncharacterized protein family UPF0029
E4O00_07105	COG0658	competence protein
E4O00_07105	COG2333	competence protein COMEC
E4O00_07125	COG2604	Protein of unknown function DUF115
E4O00_07130	COG0768	penicillin binding
E4O00_07140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O00_07165	COG0497	DNA recombination
E4O00_07185	COG0791	NLP P60 protein
E4O00_07185	COG1388	LysM domain
E4O00_07195	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O00_07205	COG0312	modulator of DNA gyrase
E4O00_07250	COG0840	transmembrane signaling receptor activity
E4O00_07275	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4O00_07280	COG0714	Associated with various cellular activities
E4O00_07295	COG3621	Patatin-like phospholipase
E4O00_07315	COG4475	Protein of unknown function (DUF436)
E4O00_07335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O00_07350	COG4608	Belongs to the ABC transporter superfamily
E4O00_07390	COG0840	transmembrane signaling receptor activity
E4O00_07395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O00_07400	COG3118	belongs to the thioredoxin family
E4O00_07410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4O00_07415	COG4750	Nucleotidyl transferase
E4O00_07420	COG1115	amino acid carrier protein
E4O00_07440	COG1193	negative regulation of DNA recombination
E4O00_07490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O00_07500	COG1702	phosphate starvation-inducible protein PhoH
E4O00_07515	COG0149	triose-phosphate isomerase activity
E4O00_07540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O00_07560	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O00_07565	COG1121	(ABC) transporter
E4O00_07570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O00_07575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O00_07600	COG1157	protein secretion by the type III secretion system
E4O00_07605	COG1317	bacterial-type flagellum organization
E4O00_07615	COG1766	The M ring may be actively involved in energy transduction
E4O00_07620	COG1677	Flagellar hook-basal body complex protein FliE
E4O00_07640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O00_07645	COG4974	Belongs to the 'phage' integrase family
E4O00_07655	COG0758	DNA mediated transformation
E4O00_07665	COG4974	Belongs to the 'phage' integrase family
E4O00_07670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O00_07705	COG2001	Belongs to the MraZ family
E4O00_07745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O00_07755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O00_07770	COG0459	protein refolding
E4O00_07785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O00_07790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O00_07830	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O00_07850	COG3033	Beta-eliminating lyase
E4O00_07860	COG0563	adenylate kinase activity
E4O00_07875	COG0019	diaminopimelate decarboxylase activity
E4O00_07880	COG0779	Required for maturation of 30S ribosomal subunits
E4O00_07890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O00_07895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O00_07900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O00_07960	COG3339	Conserved Protein
E4O00_07990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O00_08000	COG3330	Domain of unknown function (DUF4912)
E4O00_08015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O00_08025	COG3706	GGDEF domain
E4O00_08030	COG1102	Psort location Cytoplasmic, score
E4O00_08035	COG1561	YicC-like family, N-terminal region
E4O00_08045	COG0285	dihydrofolate synthase activity
E4O00_08070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O00_08105	COG0601	transmembrane transport
E4O00_08110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O00_08115	COG0444	Belongs to the ABC transporter superfamily
E4O00_08120	COG4608	Belongs to the ABC transporter superfamily
E4O00_08130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O00_08130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O00_08140	COG5433	transposase activity
E4O00_08180	COG1132	(ABC) transporter
E4O00_08190	COG1757	Na H antiporter
E4O00_08195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O00_08230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O00_08235	COG0049	tRNA binding
E4O00_08240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O00_08250	COG2832	Protein of unknown function (DUF454)
E4O00_08265	COG0756	dUTP diphosphatase activity
E4O00_08275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O00_08280	COG0196	riboflavin kinase activity
E4O00_08295	COG0598	Magnesium transport protein CorA
E4O00_08300	COG0617	tRNA 3'-terminal CCA addition
E4O00_08310	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O00_08315	COG0571	ribonuclease III activity
E4O00_08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O00_08325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O00_08335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O00_08355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O00_08355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O00_08385	COG2183	response to ionizing radiation
E4O00_08395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O00_08405	COG0495	leucyl-tRNA aminoacylation
E4O00_08410	COG1053	succinate dehydrogenase
E4O00_08410	COG3976	FMN-binding domain protein
E4O00_08415	COG0750	zinc metalloprotease
E4O00_08420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O00_08425	COG0575	Belongs to the CDS family
E4O00_08430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O00_08435	COG0233	cytoplasmic translational termination
E4O00_08440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O00_08450	COG0424	maF-like protein
E4O00_08455	COG1413	lyase activity
E4O00_08475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O00_08480	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O00_08485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O00_08505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4O00_08525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O00_08545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O00_08550	COG1131	(ABC) transporter
E4O00_08565	COG4585	Histidine kinase
E4O00_08575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O00_08585	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O00_08625	COG0740	serine-type endopeptidase activity
E4O00_08640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O00_08650	COG1847	R3H domain protein
E4O00_08655	COG0706	membrane insertase activity
E4O00_08660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O00_08670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O00_08690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O00_08725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O00_08750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O00_08765	COG0058	SHG alpha-glucan phosphorylase activity
E4O00_08785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O00_08790	COG0085	RNA polymerase activity
E4O00_08795	COG0222	ribosome binding
E4O00_08805	COG0081	regulation of translation
E4O00_08810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O00_08815	COG0250	Participates in transcription elongation, termination and antitermination
E4O00_08820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O00_08830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O00_08865	COG1652	LysM domain
E4O00_08895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O00_08900	COG1363	Peptidase, m42
E4O00_08905	COG0281	malic enzyme
E4O00_08910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4O00_08925	COG2078	PFAM AMMECR1 domain protein
E4O00_08925	COG3885	ferrous iron binding
E4O00_08930	COG0666	response to abiotic stimulus
E4O00_08935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O00_08950	COG1129	ABC transporter
E4O00_08960	COG1131	(ABC) transporter
E4O00_08995	COG1733	regulation of RNA biosynthetic process
E4O00_09045	COG1309	transcriptional regulator
E4O00_09050	COG1132	(ABC) transporter
E4O00_09050	COG2375	cellular response to nickel ion
E4O00_09060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O00_09080	COG0425	Belongs to the sulfur carrier protein TusA family
E4O00_09095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O00_09105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O00_09115	COG0549	Belongs to the carbamate kinase family
E4O00_09130	COG2801	Transposase and inactivated derivatives
E4O00_09140	COG1921	L-seryl-tRNASec selenium transferase activity
E4O00_09145	COG0322	excinuclease ABC activity
E4O00_09205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O00_09210	COG1573	uracil-dna glycosylase
E4O00_09220	COG0840	transmembrane signaling receptor activity
E4O00_09240	COG0745	RESPONSE REGULATOR receiver
E4O00_09250	COG5433	transposase activity
E4O00_09265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O00_09295	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4O00_09300	COG3421	Type III restriction
E4O00_09310	COG1012	belongs to the aldehyde dehydrogenase family
E4O00_09355	COG4115	mRNA cleavage
E4O00_09370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O00_09380	COG1132	(ABC) transporter
E4O00_09390	COG2604	Protein of unknown function DUF115
E4O00_09450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O00_09490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O00_09505	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O00_09510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O00_09520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O00_09540	COG1129	ABC transporter
E4O00_09545	COG1132	(ABC) transporter
E4O00_09560	COG1132	(ABC) transporter
E4O00_09565	COG1132	(ABC) transporter
E4O00_09590	COG1741	Belongs to the pirin family
E4O00_09615	COG2274	protein secretion by the type I secretion system
E4O00_09635	COG0840	transmembrane signaling receptor activity
E4O00_09635	COG3290	protein histidine kinase activity
E4O00_09670	COG4942	peptidase
E4O00_09675	COG0640	Transcriptional regulator
E4O00_09690	COG4152	abc transporter atp-binding protein
E4O00_09730	COG5433	transposase activity
E4O00_09835	COG1690	Belongs to the RtcB family
E4O00_09840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4O00_09860	COG2910	NAD(P)H-binding
E4O00_09865	COG1959	2 iron, 2 sulfur cluster binding
E4O00_09870	COG0456	acetyltransferase
E4O00_09885	COG0584	glycerophosphoryl diester phosphodiesterase
E4O00_09895	COG1254	Belongs to the acylphosphatase family
E4O00_09915	COG0203	ribosomal protein L17
E4O00_09920	COG0202	RNA polymerase activity
E4O00_09925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O00_09930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O00_09935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O00_09945	COG0200	Binds to the 23S rRNA
E4O00_09950	COG1841	ribosomal large subunit assembly
E4O00_09955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O00_09960	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O00_09965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O00_09970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O00_09975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O00_09980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O00_09985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O00_09990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O00_09995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O00_10000	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O00_10005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O00_10010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O00_10015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O00_10020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O00_10025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O00_10030	COG0089	rRNA binding
E4O00_10035	COG0088	Forms part of the polypeptide exit tunnel
E4O00_10040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O00_10070	COG0135	phosphoribosylanthranilate isomerase activity
E4O00_10090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O00_10100	COG3118	belongs to the thioredoxin family
E4O00_10150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O00_10160	COG1086	Polysaccharide biosynthesis protein
E4O00_10210	COG3177	Filamentation induced by cAMP protein fic
E4O00_10220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4O00_10220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4O00_10225	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O00_10235	COG3448	diguanylate cyclase activity
E4O00_10235	COG4175	Glycine betaine
E4O00_10245	COG0095	Lipoate-protein ligase
E4O00_10260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4O00_10275	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O00_10280	COG0784	Response regulator, receiver
E4O00_10280	COG3437	response regulator, receiver
E4O00_10300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O00_10310	COG5433	transposase activity
E4O00_10315	COG0517	IMP dehydrogenase activity
E4O00_10315	COG0516	GMP reductase activity
E4O00_10330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O00_10335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O00_10365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O00_10395	COG1191	sigma factor activity
E4O00_10425	COG0504	CTP synthase activity
E4O00_10450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O00_10450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O00_10450	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O00_10450	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O00_10455	COG2885	chlorophyll binding
E4O00_10470	COG2378	regulation of single-species biofilm formation
E4O00_10495	COG0642	Histidine kinase
E4O00_10500	COG0745	RESPONSE REGULATOR receiver
E4O00_10505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O00_10525	COG2201	protein-glutamate methylesterase activity
E4O00_10545	COG1137	ATPase activity
E4O00_10550	COG0193	aminoacyl-tRNA hydrolase activity
E4O00_10560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O00_10565	COG0840	transmembrane signaling receptor activity
E4O00_10570	COG0601	transmembrane transport
E4O00_10575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O00_10580	COG0444	Belongs to the ABC transporter superfamily
E4O00_10585	COG4608	Belongs to the ABC transporter superfamily
E4O00_10590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O00_10620	COG0443	Heat shock 70 kDa protein
E4O00_10625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O00_10630	COG3177	Filamentation induced by cAMP protein fic
E4O00_10640	COG1120	ATPase activity
E4O00_10665	COG0534	Mate efflux family protein
E4O00_10680	COG2801	Transposase and inactivated derivatives
E4O00_10740	COG1192	Involved in chromosome partitioning
E4O00_10745	COG1475	DNA binding
E4O00_10760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O00_10765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O00_10775	COG1028	Short-chain dehydrogenase reductase Sdr
E4O00_10780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O00_10810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O00_10815	COG0825	malonyl-CoA metabolic process
E4O00_10850	COG0701	Predicted permease
E4O00_10860	COG0714	Associated with various cellular activities
E4O00_10895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O00_10900	COG0154	amidase activity
E4O00_10905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O00_10965	COG1151	hydroxylamine reductase activity
E4O00_10980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4O00_10985	COG1136	(ABC) transporter
E4O00_10985	COG0577	efflux transmembrane transporter activity
E4O00_11030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O00_11055	COG0813	purine-nucleoside phosphorylase activity
E4O00_11065	COG0840	transmembrane signaling receptor activity
E4O00_11080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O00_11090	COG0037	tRNA processing
E4O00_11105	COG2235	arginine
E4O00_11120	COG0569	domain protein
E4O00_11125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O00_11145	COG0215	cysteine-tRNA ligase activity
E4O00_11150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O00_11170	COG3177	Filamentation induced by cAMP protein fic
E4O00_11180	COG1506	peptidase
E4O00_11180	COG0823	Involved in the tonB-independent uptake of proteins
E4O00_11180	COG4946	Tricorn protease homolog
E4O00_11195	COG2801	Transposase and inactivated derivatives
E4O00_11230	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O00_11235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O00_11260	COG1129	ABC transporter
E4O00_11265	COG1609	Transcriptional regulator
E4O00_11275	COG0366	Alpha amylase catalytic
E4O00_11290	COG0739	heme binding
E4O00_11300	COG1728	Protein conserved in bacteria
E4O00_11305	COG1774	PSP1 C-terminal conserved region
E4O00_11320	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O00_11380	COG5002	protein histidine kinase activity
E4O00_11380	COG5001	Diguanylate cyclase
E4O00_11385	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O00_11385	COG0540	Belongs to the ATCase OTCase family
E4O00_11400	COG2186	Transcriptional regulator
E4O00_11410	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O00_11420	COG1070	Carbohydrate kinase
E4O00_11515	COG1473	amidohydrolase
E4O00_11570	COG0800	Aldolase
E4O00_11585	COG0716	FMN binding
E4O00_11605	COG1131	(ABC) transporter
E4O00_11615	COG0840	transmembrane signaling receptor activity
E4O00_11625	COG0419	ATPase involved in DNA repair
E4O00_11645	COG1968	undecaprenyl-diphosphatase activity
E4O00_11650	COG1674	ftsk spoiiie
E4O00_11655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O00_11680	COG5433	transposase activity
E4O00_11695	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O00_11715	COG1929	Belongs to the glycerate kinase type-1 family
E4O00_11720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O00_11885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O00_11890	COG0592	DNA-directed DNA polymerase activity
E4O00_11895	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O00_11915	COG3118	belongs to the thioredoxin family
E4O00_11940	COG2855	membrane
E4O00_11945	COG0363	glucosamine-6-phosphate deaminase activity
E4O00_11950	COG0628	permease
E4O00_11955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O00_11980	COG0534	Mate efflux family protein
E4O00_11985	COG1309	transcriptional regulator
E4O00_12010	COG0514	ATP-dependent DNA helicase (RecQ)
E4O00_12025	COG4536	flavin adenine dinucleotide binding
E4O00_12030	COG4536	flavin adenine dinucleotide binding
E4O00_12035	COG0714	Associated with various cellular activities
E4O00_12055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O00_12080	COG1136	(ABC) transporter
E4O00_12100	COG5012	cobalamin binding
E4O00_12120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4O00_12125	COG0616	signal peptide processing
E4O00_12130	COG0012	GTP binding
E4O00_12155	COG3706	GGDEF domain
E4O00_12175	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4O00_12185	COG1924	4 iron, 4 sulfur cluster binding
E4O00_12195	COG1653	transport
E4O00_12200	COG0395	ABC-type sugar transport system, permease component
E4O00_12225	COG4166	transmembrane transport
E4O00_12230	COG0601	transmembrane transport
E4O00_12235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O00_12240	COG0444	Belongs to the ABC transporter superfamily
E4O00_12245	COG4608	Belongs to the ABC transporter superfamily
E4O00_12250	COG1840	ABC-type Fe3 transport system, periplasmic component
E4O00_12265	COG3842	ATPase activity
E4O00_12270	COG0438	transferase activity, transferring glycosyl groups
E4O00_12325	COG3339	Conserved Protein
E4O00_12340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4O00_12355	COG0786	glutamate:sodium symporter activity
E4O00_12360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O00_12365	COG3588	fructose-bisphosphate aldolase
E4O00_12370	COG1487	ribonuclease activity
E4O00_12385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O00_12405	COG1136	(ABC) transporter
E4O00_12425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4O00_12435	COG0569	domain protein
E4O00_12440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O00_12470	COG0543	2 iron, 2 sulfur cluster binding
E4O00_12480	COG0501	Belongs to the peptidase M48B family
E4O00_12535	COG1592	Rubrerythrin
E4O00_12540	COG0514	ATP-dependent DNA helicase (RecQ)
E4O00_12545	COG1381	Involved in DNA repair and RecF pathway recombination
E4O00_12555	COG0343	queuine tRNA-ribosyltransferase activity
E4O00_12570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O00_12585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O00_12595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O00_12605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O00_12630	COG0826	peptidase U32
E4O00_12635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O00_12640	COG1509	lysine 2,3-aminomutase activity
E4O00_12650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O00_12665	COG0205	6-phosphofructokinase activity
E4O00_12765	COG2801	Transposase and inactivated derivatives
E4O00_12790	COG1373	ATPase (AAA superfamily
E4O00_12925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O00_12935	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O00_12940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O00_12950	COG1987	bacterial-type flagellum assembly
E4O00_12990	COG1228	amidohydrolase
E4O00_13010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O00_13015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O00_13020	COG2217	Heavy metal translocating P-type atpase
E4O00_13030	COG0494	nUDIX hydrolase
E4O00_13035	COG0783	Belongs to the Dps family
E4O00_13040	COG0450	alkyl hydroperoxide reductase
E4O00_13045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O00_13060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4O00_13065	COG1363	Peptidase, m42
E4O00_13075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O00_13080	COG0423	glycine-tRNA ligase activity
E4O00_13140	COG1401	restriction endodeoxyribonuclease activity
E4O00_13145	COG0537	adenosine 5'-monophosphoramidase activity
E4O00_13170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4O00_13170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4O00_13185	COG0280	phosphate acetyltransferase
E4O00_13190	COG0457	Tetratricopeptide repeat
E4O00_13195	COG1393	Belongs to the ArsC family
E4O00_13215	COG0187	DNA topoisomerase II activity