locus-tag	class	description
E4O06_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O06_00025	COG0587	DNA-directed DNA polymerase activity
E4O06_00050	COG1132	(ABC) transporter
E4O06_00065	COG1132	(ABC) transporter
E4O06_00120	COG1473	amidohydrolase
E4O06_00125	COG0745	RESPONSE REGULATOR receiver
E4O06_00130	COG5002	protein histidine kinase activity
E4O06_00135	COG1136	(ABC) transporter
E4O06_00180	COG2378	regulation of single-species biofilm formation
E4O06_00195	COG2885	chlorophyll binding
E4O06_00200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O06_00200	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O06_00200	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O06_00200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O06_00210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4O06_00210	COG1747	RNA polymerase binding
E4O06_00225	COG0504	CTP synthase activity
E4O06_00235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4O06_00240	COG1419	protein localization to endoplasmic reticulum
E4O06_00255	COG1191	sigma factor activity
E4O06_00285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O06_00315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4O06_00320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_00325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O06_00340	COG0516	GMP reductase activity
E4O06_00345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O06_00365	COG3437	response regulator, receiver
E4O06_00365	COG0784	Response regulator, receiver
E4O06_00370	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O06_00425	COG1132	(ABC) transporter
E4O06_00430	COG0517	IMP dehydrogenase activity
E4O06_00430	COG4175	Glycine betaine
E4O06_00440	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_00445	COG0579	oxidoreductase
E4O06_00455	COG3177	Filamentation induced by cAMP protein fic
E4O06_00505	COG1086	Polysaccharide biosynthesis protein
E4O06_00535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4O06_00575	COG0793	Belongs to the peptidase S41A family
E4O06_00575	COG3409	Peptidoglycan-binding domain 1 protein
E4O06_00585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O06_00635	COG3118	belongs to the thioredoxin family
E4O06_00645	COG1120	ATPase activity
E4O06_00650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_00665	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_00665	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_00670	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_00675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O06_00695	COG0732	type I restriction modification DNA specificity domain
E4O06_00715	COG0732	type I restriction modification DNA specificity domain
E4O06_00725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4O06_00730	COG0135	phosphoribosylanthranilate isomerase activity
E4O06_00735	COG1757	Na H antiporter
E4O06_00740	COG1120	ATPase activity
E4O06_00745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4O06_00775	COG0051	transcription antitermination factor activity, RNA binding
E4O06_00780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O06_00785	COG0088	Forms part of the polypeptide exit tunnel
E4O06_00790	COG0089	rRNA binding
E4O06_00795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O06_00800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O06_00805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O06_00810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O06_00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O06_00820	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O06_00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O06_00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O06_00835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O06_00840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O06_00845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O06_00850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O06_00855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O06_00860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O06_00865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O06_00870	COG1841	ribosomal large subunit assembly
E4O06_00875	COG0200	Binds to the 23S rRNA
E4O06_00885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O06_00890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O06_00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O06_00900	COG0202	RNA polymerase activity
E4O06_00905	COG0203	ribosomal protein L17
E4O06_00925	COG1254	Belongs to the acylphosphatase family
E4O06_00945	COG0584	glycerophosphoryl diester phosphodiesterase
E4O06_00965	COG2226	methyltransferase
E4O06_00970	COG1959	2 iron, 2 sulfur cluster binding
E4O06_00975	COG2910	NAD(P)H-binding
E4O06_00995	COG0840	transmembrane signaling receptor activity
E4O06_01090	COG1131	(ABC) transporter
E4O06_01105	COG0640	Transcriptional regulator
E4O06_01110	COG0840	transmembrane signaling receptor activity
E4O06_01120	COG4942	peptidase
E4O06_01140	COG0840	transmembrane signaling receptor activity
E4O06_01140	COG3290	protein histidine kinase activity
E4O06_01155	COG2207	Transcriptional regulator
E4O06_01160	COG2274	protein secretion by the type I secretion system
E4O06_01165	COG1132	(ABC) transporter
E4O06_01175	COG1741	Belongs to the pirin family
E4O06_01195	COG0515	serine threonine protein kinase
E4O06_01195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4O06_01220	COG1132	(ABC) transporter
E4O06_01230	COG1129	ABC transporter
E4O06_01250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O06_01255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O06_01260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O06_01275	COG1132	(ABC) transporter
E4O06_01280	COG4988	ABC transporter
E4O06_01290	COG1121	(ABC) transporter
E4O06_01295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_01325	COG0301	tRNA thio-modification
E4O06_01330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4O06_01335	COG4443	Transcriptional Coactivator p15 (PC4)
E4O06_01340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_01345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O06_01360	COG4657	Part of a membrane complex involved in electron transport
E4O06_01365	COG4660	Part of a membrane complex involved in electron transport
E4O06_01370	COG4659	FMN binding
E4O06_01375	COG4658	electron transport chain
E4O06_01380	COG4656	Part of a membrane complex involved in electron transport
E4O06_01390	COG2304	oxidoreductase activity
E4O06_01410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O06_01425	COG0840	transmembrane signaling receptor activity
E4O06_01440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O06_01455	COG0745	RESPONSE REGULATOR receiver
E4O06_01480	COG1187	pseudouridine synthase activity
E4O06_01485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O06_01495	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O06_01500	COG4988	ABC transporter
E4O06_01525	COG1362	aminopeptidase activity
E4O06_01530	COG0445	tRNA wobble uridine modification
E4O06_01555	COG2604	Protein of unknown function DUF115
E4O06_01570	COG1132	(ABC) transporter
E4O06_01595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O06_01605	COG4115	mRNA cleavage
E4O06_01620	COG0357	Ribosomal RNA small subunit methyltransferase G
E4O06_01625	COG1012	belongs to the aldehyde dehydrogenase family
E4O06_01645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O06_01660	COG0745	RESPONSE REGULATOR receiver
E4O06_01690	COG1573	uracil-dna glycosylase
E4O06_01695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O06_01720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4O06_01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O06_01725	COG2890	protein-(glutamine-N5) methyltransferase activity
E4O06_01750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O06_01785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O06_01795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_01800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O06_01810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O06_01815	COG0706	membrane insertase activity
E4O06_01820	COG1847	R3H domain protein
E4O06_01830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O06_01845	COG0740	serine-type endopeptidase activity
E4O06_01860	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O06_01870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O06_01880	COG4585	Histidine kinase
E4O06_01895	COG1131	(ABC) transporter
E4O06_01900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O06_01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O06_01935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O06_01945	COG1757	Na H antiporter
E4O06_01965	COG2376	Dihydroxyacetone kinase
E4O06_01970	COG2376	Dihydroxyacetone kinase
E4O06_01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_02005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O06_02010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O06_02015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_02035	COG1413	lyase activity
E4O06_02040	COG0424	maF-like protein
E4O06_02045	COG0052	Belongs to the universal ribosomal protein uS2 family
E4O06_02050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O06_02055	COG0233	cytoplasmic translational termination
E4O06_02060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O06_02065	COG0575	Belongs to the CDS family
E4O06_02070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O06_02075	COG0750	zinc metalloprotease
E4O06_02085	COG0495	leucyl-tRNA aminoacylation
E4O06_02100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O06_02110	COG2183	response to ionizing radiation
E4O06_02115	COG2703	oxygen carrier activity
E4O06_02125	COG1067	ATP-dependent peptidase activity
E4O06_02140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O06_02140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O06_02160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O06_02170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O06_02175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O06_02180	COG0571	ribonuclease III activity
E4O06_02185	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O06_02195	COG0617	tRNA 3'-terminal CCA addition
E4O06_02200	COG0598	Magnesium transport protein CorA
E4O06_02210	COG0840	transmembrane signaling receptor activity
E4O06_02215	COG0196	riboflavin kinase activity
E4O06_02220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O06_02225	COG1185	polyribonucleotide nucleotidyltransferase activity
E4O06_02230	COG0756	dUTP diphosphatase activity
E4O06_02245	COG4865	methylaspartate mutase activity
E4O06_02255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4O06_02260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_02265	COG1120	ATPase activity
E4O06_02270	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_02280	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O06_02300	COG0442	prolyl-tRNA aminoacylation
E4O06_02320	COG1879	ABC-type sugar transport system periplasmic component
E4O06_02325	COG1129	ABC transporter
E4O06_02330	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O06_02335	COG2226	methyltransferase
E4O06_02350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_02360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4O06_02375	COG2056	Na+-H+ antiporter family
E4O06_02380	COG1757	Na H antiporter
E4O06_02385	COG0697	spore germination
E4O06_02395	COG0626	cystathionine gamma-synthase activity
E4O06_02400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O06_02405	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O06_02405	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O06_02405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O06_02405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_02410	COG0564	pseudouridine synthase activity
E4O06_02415	COG0156	8-amino-7-oxononanoate synthase activity
E4O06_02425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O06_02435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4O06_02435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4O06_02440	COG0739	heme binding
E4O06_02450	COG1475	DNA binding
E4O06_02455	COG1022	Amp-dependent synthetase and ligase
E4O06_02480	COG0671	phosphoesterase, PA-phosphatase related
E4O06_02485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O06_02545	COG2738	Putative neutral zinc metallopeptidase
E4O06_02560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O06_02575	COG1129	ABC transporter
E4O06_02615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O06_02620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O06_02630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O06_02635	COG1671	Belongs to the UPF0178 family
E4O06_02645	COG1388	LysM domain
E4O06_02645	COG0741	lytic transglycosylase activity
E4O06_02670	COG3681	Belongs to the UPF0597 family
E4O06_02675	COG4953	penicillin-binding protein 1C
E4O06_02680	COG1770	oligopeptidase
E4O06_02705	COG1114	Component of the transport system for branched-chain amino acids
E4O06_02720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_02745	COG2723	6-phospho-beta-galactosidase activity
E4O06_02760	COG0488	(ABC) transporter
E4O06_02790	COG1266	CAAX protease self-immunity
E4O06_02795	COG1266	CAAX protease self-immunity
E4O06_02835	COG2274	protein secretion by the type I secretion system
E4O06_02835	COG3271	cysteine-type peptidase activity
E4O06_02845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O06_02850	COG0632	four-way junction helicase activity
E4O06_02880	COG2056	Na+-H+ antiporter family
E4O06_02900	COG1136	(ABC) transporter
E4O06_02935	COG1122	ATPase activity
E4O06_02980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4O06_02990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O06_03025	COG1132	(ABC) transporter
E4O06_03045	COG2208	phosphoserine phosphatase activity
E4O06_03045	COG2770	Histidine kinase
E4O06_03050	COG1131	(ABC) transporter
E4O06_03070	COG0284	orotidine-5'-phosphate decarboxylase activity
E4O06_03090	COG0513	Belongs to the DEAD box helicase family
E4O06_03100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O06_03145	COG3876	Protein conserved in bacteria
E4O06_03150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O06_03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4O06_03170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O06_03175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O06_03180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O06_03185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O06_03190	COG0484	heat shock protein binding
E4O06_03195	COG0528	UMP kinase activity
E4O06_03200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O06_03215	COG0539	negative regulation of cytoplasmic translation
E4O06_03220	COG2204	response regulator
E4O06_03225	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O06_03245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O06_03270	COG0251	oxidation-reduction process
E4O06_03275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O06_03280	COG1722	exodeoxyribonuclease VII activity
E4O06_03300	COG1918	ferrous iron import across plasma membrane
E4O06_03305	COG1918	ferrous iron import across plasma membrane
E4O06_03305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O06_03350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O06_03380	COG4166	transmembrane transport
E4O06_03395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4O06_03410	COG0552	protein localization to endoplasmic reticulum
E4O06_03420	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O06_03425	COG1136	(ABC) transporter
E4O06_03435	COG3880	PFAM UvrB UvrC protein
E4O06_03440	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O06_03450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O06_03455	COG0438	transferase activity, transferring glycosyl groups
E4O06_03465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O06_03475	COG0084	hydrolase, TatD family'
E4O06_03480	COG2885	chlorophyll binding
E4O06_03570	COG3039	Transposase
E4O06_03595	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_03605	COG1288	antiporter activity
E4O06_03630	COG1309	transcriptional regulator
E4O06_03640	COG1164	Oligoendopeptidase f
E4O06_03645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O06_03650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O06_03655	COG0606	chelatase, subunit chli
E4O06_03665	COG2885	chlorophyll binding
E4O06_03670	COG0433	COG0433 Predicted ATPase
E4O06_03680	COG0768	penicillin binding
E4O06_03685	COG2604	Protein of unknown function DUF115
E4O06_03710	COG1739	Uncharacterized protein family UPF0029
E4O06_03735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O06_03745	COG0330	HflC and HflK could
E4O06_03750	COG0330	HflC and HflK could
E4O06_03770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O06_03775	COG2088	sporulation resulting in formation of a cellular spore
E4O06_03785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O06_03790	COG0037	tRNA processing
E4O06_03795	COG0457	Tetratricopeptide repeat
E4O06_03800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_03815	COG0358	DNA primase activity
E4O06_03820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_03840	COG1077	Cell shape determining protein MreB Mrl
E4O06_03855	COG0768	penicillin binding
E4O06_03860	COG0772	Belongs to the SEDS family
E4O06_03895	COG2252	PERMEase
E4O06_03920	COG1794	racemase activity, acting on amino acids and derivatives
E4O06_03975	COG1715	Restriction endonuclease
E4O06_04115	COG0534	Mate efflux family protein
E4O06_04410	COG3039	Transposase
E4O06_04445	COG2226	methyltransferase
E4O06_04460	COG0406	alpha-ribazole phosphatase activity
E4O06_04470	COG3039	Transposase
E4O06_04480	COG1418	mRNA catabolic process
E4O06_04510	COG2033	superoxide reductase activity
E4O06_04515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O06_04525	COG2720	vancomycin resistance protein
E4O06_04530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O06_04540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O06_04545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O06_04560	COG0799	negative regulation of ribosome biogenesis
E4O06_04565	COG2059	Chromate
E4O06_04610	COG0739	heme binding
E4O06_04620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_04630	COG0708	Exodeoxyribonuclease III
E4O06_04635	COG0024	Methionine aminopeptidase
E4O06_04640	COG0484	heat shock protein binding
E4O06_04660	COG1233	COG1233 Phytoene dehydrogenase and related
E4O06_04665	COG1017	nitric oxide dioxygenase activity
E4O06_04665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4O06_04680	COG0617	tRNA 3'-terminal CCA addition
E4O06_04695	COG0519	Catalyzes the synthesis of GMP from XMP
E4O06_04705	COG0126	phosphoglycerate kinase activity
E4O06_04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4O06_04730	COG0268	Binds directly to 16S ribosomal RNA
E4O06_04740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O06_04750	COG1058	Belongs to the CinA family
E4O06_04750	COG1546	Belongs to the CinA family
E4O06_04800	COG0588	phosphoglycerate mutase activity
E4O06_04820	COG1131	(ABC) transporter
E4O06_04830	COG0457	Tetratricopeptide repeat
E4O06_04835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O06_04840	COG2203	Gaf domain
E4O06_04840	COG3706	GGDEF domain
E4O06_04840	COG4251	negative regulation of phosphorylation
E4O06_04840	COG5001	Diguanylate cyclase
E4O06_04845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O06_04850	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O06_04855	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O06_04860	COG1394	ATPase activity, coupled to movement of substances
E4O06_04865	COG1269	ATP hydrolysis coupled proton transport
E4O06_04875	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O06_04880	COG0629	single-stranded DNA binding
E4O06_04885	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O06_04890	COG0359	binds to the 23S rRNA
E4O06_04900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O06_04905	COG0740	serine-type endopeptidase activity
E4O06_04910	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O06_04930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O06_04940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O06_04960	COG0305	Participates in initiation and elongation during chromosome replication
E4O06_04970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O06_04975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O06_04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O06_05000	COG1268	BioY protein
E4O06_05005	COG1122	ATPase activity
E4O06_05030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_05045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O06_05050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O06_05060	COG0237	dephospho-CoA kinase activity
E4O06_05065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O06_05065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O06_05065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O06_05085	COG3052	prosthetic group binding
E4O06_05105	COG1737	Transcriptional regulator
E4O06_05110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O06_05120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_05135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4O06_05140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O06_05145	COG0509	glycine decarboxylation via glycine cleavage system
E4O06_05150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O06_05155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O06_05195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O06_05200	COG0493	'glutamate synthase
E4O06_05200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_05225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O06_05255	COG1051	belongs to the nudix hydrolase family
E4O06_05270	COG1051	belongs to the nudix hydrolase family
E4O06_05305	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O06_05310	COG0488	(ABC) transporter
E4O06_05315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4O06_05325	COG0835	chemotaxis
E4O06_05335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4O06_05355	COG0297	glycogen (starch) synthase activity
E4O06_05360	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O06_05365	COG2982	Protein involved in outer membrane biogenesis
E4O06_05390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_05395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O06_05400	COG0095	Lipoate-protein ligase
E4O06_05405	COG4608	Belongs to the ABC transporter superfamily
E4O06_05410	COG0444	Belongs to the ABC transporter superfamily
E4O06_05415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_05420	COG0601	transmembrane transport
E4O06_05425	COG0747	negative chemotaxis
E4O06_05430	COG0205	6-phosphofructokinase activity
E4O06_05435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O06_05440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O06_05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O06_05465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O06_05480	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O06_05500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4O06_05505	COG0142	geranyltranstransferase activity
E4O06_05515	COG1692	metallophosphoesterase
E4O06_05545	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O06_05575	COG1136	(ABC) transporter
E4O06_05580	COG0577	efflux transmembrane transporter activity
E4O06_05595	COG3470	protein probably involved in high-affinity Fe2 transport
E4O06_05600	COG0672	)-iron permease
E4O06_05605	COG1136	(ABC) transporter
E4O06_05615	COG1760	l-serine dehydratase
E4O06_05620	COG1760	l-serine dehydratase
E4O06_05630	COG0254	rRNA binding
E4O06_05635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O06_05650	COG0574	Belongs to the PEP-utilizing enzyme family
E4O06_05650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O06_05660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O06_05715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O06_05725	COG1196	nuclear chromosome segregation
E4O06_05735	COG2201	protein-glutamate methylesterase activity
E4O06_05745	COG0835	chemotaxis
E4O06_05750	COG0643	Histidine kinase
E4O06_05750	COG2198	Histidine kinase
E4O06_05765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O06_05770	COG0217	transcriptional regulatory protein
E4O06_05805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_05810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_05820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O06_05820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O06_05835	COG0802	atpase or kinase
E4O06_05845	COG2770	Histidine kinase
E4O06_05845	COG3437	response regulator, receiver
E4O06_05850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O06_05860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O06_05905	COG1136	(ABC) transporter
E4O06_05935	COG0745	RESPONSE REGULATOR receiver
E4O06_05935	COG2205	protein histidine kinase activity
E4O06_05935	COG3292	Two component regulator propeller
E4O06_05940	COG0745	RESPONSE REGULATOR receiver
E4O06_05950	COG2211	Major facilitator Superfamily
E4O06_05950	COG2190	(PTS) system
E4O06_05960	COG1193	negative regulation of DNA recombination
E4O06_05965	COG1162	GTPase activity
E4O06_05975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O06_05990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O06_06000	COG0124	histidyl-tRNA synthetase
E4O06_06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_06020	COG0297	glycogen (starch) synthase activity
E4O06_06030	COG0706	membrane insertase activity
E4O06_06045	COG0706	membrane insertase activity
E4O06_06055	COG0463	Glycosyl transferase, family 2
E4O06_06060	COG3306	glycosyltransferase involved in LPS biosynthesis
E4O06_06065	COG1442	glycosyl transferase family 8
E4O06_06065	COG1216	Glycosyl transferase, family 2
E4O06_06100	COG1216	Glycosyl transferase, family 2
E4O06_06100	COG0463	Glycosyl transferase, family 2
E4O06_06125	COG2089	acid synthase
E4O06_06145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_06145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_06155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_06195	COG4310	Domain of unknown function (DUF2172)
E4O06_06205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O06_06210	COG1083	cytidylyl-transferase
E4O06_06220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O06_06225	COG1086	Polysaccharide biosynthesis protein
E4O06_06255	COG1373	ATPase (AAA superfamily
E4O06_06260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4O06_06265	COG0028	Belongs to the TPP enzyme family
E4O06_06265	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4O06_06285	COG0475	glutathione-regulated potassium exporter activity
E4O06_06310	COG1078	dGTPase activity
E4O06_06320	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O06_06330	COG0488	(ABC) transporter
E4O06_06345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O06_06345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O06_06350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O06_06360	COG0455	bacterial-type flagellum organization
E4O06_06390	COG4656	Part of a membrane complex involved in electron transport
E4O06_06405	COG0564	pseudouridine synthase activity
E4O06_06410	COG2217	Heavy metal translocating P-type atpase
E4O06_06415	COG0640	Transcriptional regulator
E4O06_06420	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O06_06440	COG2878	Part of a membrane complex involved in electron transport
E4O06_06445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O06_06450	COG0138	bifunctional purine biosynthesis protein purh
E4O06_06455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O06_06460	COG0653	protein targeting
E4O06_06465	COG1725	Transcriptional regulator
E4O06_06485	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O06_06495	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4O06_06500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O06_06505	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O06_06515	COG2255	four-way junction helicase activity
E4O06_06520	COG1979	alcohol dehydrogenase
E4O06_06525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_06540	COG0731	radical SAM domain protein
E4O06_06555	COG1047	Peptidyl-prolyl cis-trans
E4O06_06590	COG0295	cytidine deaminase activity
E4O06_06610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O06_06640	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O06_06645	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O06_06650	COG3845	ABC transporter
E4O06_06655	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O06_06660	COG1234	tRNA 3'-trailer cleavage
E4O06_06680	COG0525	valine-tRNA ligase activity
E4O06_06685	COG0481	GTPase activity
E4O06_06690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O06_06700	COG0557	exoribonuclease II activity
E4O06_06705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O06_06705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O06_06710	COG0556	nucleotide-excision repair
E4O06_06715	COG1136	(ABC) transporter
E4O06_06750	COG1132	(ABC) transporter
E4O06_06755	COG1132	(ABC) transporter
E4O06_06755	COG2375	cellular response to nickel ion
E4O06_06760	COG2207	Transcriptional regulator
E4O06_06770	COG4555	ABC transporter
E4O06_06785	COG1136	(ABC) transporter
E4O06_06790	COG3271	cysteine-type peptidase activity
E4O06_06790	COG2274	protein secretion by the type I secretion system
E4O06_06800	COG0535	radical SAM domain protein
E4O06_06855	COG2378	regulation of single-species biofilm formation
E4O06_06865	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O06_06870	COG0475	glutathione-regulated potassium exporter activity
E4O06_06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_06885	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O06_06890	COG2204	response regulator
E4O06_06895	COG3852	Histidine kinase
E4O06_06900	COG0470	DNA polymerase III
E4O06_06905	COG1286	toxin biosynthetic process
E4O06_06920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O06_06925	COG1349	DNA-binding transcription factor activity
E4O06_06940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4O06_06960	COG0823	Involved in the tonB-independent uptake of proteins
E4O06_06970	COG1199	ATP-dependent helicase activity
E4O06_06975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O06_06990	COG0497	DNA recombination
E4O06_07010	COG1388	LysM domain
E4O06_07010	COG3942	CHAP domain
E4O06_07020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O06_07025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O06_07030	COG0312	modulator of DNA gyrase
E4O06_07055	COG1122	ATPase activity
E4O06_07140	COG4254	PFAM FecR protein
E4O06_07180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4O06_07185	COG4475	Protein of unknown function (DUF436)
E4O06_07200	COG3039	Transposase
E4O06_07235	COG0840	transmembrane signaling receptor activity
E4O06_07240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O06_07245	COG3118	belongs to the thioredoxin family
E4O06_07260	COG4750	Nucleotidyl transferase
E4O06_07265	COG1115	amino acid carrier protein
E4O06_07290	COG2840	Smr protein MutS2
E4O06_07345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O06_07350	COG1480	7TM receptor with intracellular HD hydrolase
E4O06_07355	COG1702	phosphate starvation-inducible protein PhoH
E4O06_07370	COG0149	triose-phosphate isomerase activity
E4O06_07390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O06_07410	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O06_07415	COG1121	(ABC) transporter
E4O06_07420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_07425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_07440	COG0457	Tetratricopeptide repeat
E4O06_07450	COG1157	protein secretion by the type III secretion system
E4O06_07455	COG1317	bacterial-type flagellum organization
E4O06_07465	COG1766	The M ring may be actively involved in energy transduction
E4O06_07470	COG1677	Flagellar hook-basal body complex protein FliE
E4O06_07485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4O06_07490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O06_07495	COG4974	Belongs to the 'phage' integrase family
E4O06_07500	COG0551	DNA topoisomerase type I activity
E4O06_07500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4O06_07505	COG0758	DNA mediated transformation
E4O06_07520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O06_07535	COG0772	Belongs to the SEDS family
E4O06_07540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4O06_07550	COG0275	rRNA processing
E4O06_07555	COG2001	Belongs to the MraZ family
E4O06_07560	COG1505	serine-type exopeptidase activity
E4O06_07595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O06_07605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O06_07645	COG0459	protein refolding
E4O06_07660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O06_07665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O06_07705	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O06_07725	COG3033	Beta-eliminating lyase
E4O06_07730	COG0563	adenylate kinase activity
E4O06_07750	COG0779	Required for maturation of 30S ribosomal subunits
E4O06_07760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O06_07765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O06_07770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O06_07790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_07800	COG0747	negative chemotaxis
E4O06_07830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4O06_07835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O06_07845	COG3330	Domain of unknown function (DUF4912)
E4O06_07860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O06_07870	COG3706	GGDEF domain
E4O06_07875	COG1102	Psort location Cytoplasmic, score
E4O06_07880	COG1561	YicC-like family, N-terminal region
E4O06_07890	COG0285	dihydrofolate synthase activity
E4O06_07910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4O06_07915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O06_07925	COG4608	Belongs to the ABC transporter superfamily
E4O06_07930	COG0444	Belongs to the ABC transporter superfamily
E4O06_07935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_07940	COG0601	transmembrane transport
E4O06_07955	COG0601	transmembrane transport
E4O06_07960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_07965	COG0444	Belongs to the ABC transporter superfamily
E4O06_07970	COG4608	Belongs to the ABC transporter superfamily
E4O06_07990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O06_07990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O06_08020	COG0534	Mate efflux family protein
E4O06_08025	COG0840	transmembrane signaling receptor activity
E4O06_08040	COG2801	Transposase and inactivated derivatives
E4O06_08075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_08080	COG0049	tRNA binding
E4O06_08085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O06_08115	COG0629	single-stranded DNA binding
E4O06_08330	COG3645	SOS response
E4O06_08355	COG2832	Protein of unknown function (DUF454)
E4O06_08360	COG3142	Participates in the control of copper homeostasis
E4O06_08385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O06_08420	COG0737	Belongs to the 5'-nucleotidase family
E4O06_08435	COG0826	peptidase U32
E4O06_08445	COG1132	(ABC) transporter
E4O06_08450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O06_08465	COG0101	tRNA pseudouridine synthase activity
E4O06_08475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O06_08480	COG1639	'signal transduction protein
E4O06_08495	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4O06_08500	COG0577	efflux transmembrane transporter activity
E4O06_08500	COG1136	(ABC) transporter
E4O06_08505	COG1136	(ABC) transporter
E4O06_08520	COG3956	TIGRFAM MazG family protein
E4O06_08525	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O06_08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O06_08540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O06_08540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O06_08545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O06_08560	COG0668	transmembrane transport
E4O06_08575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_08580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O06_08585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_08600	COG0792	nuclease activity
E4O06_08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O06_08635	COG3604	Transcriptional regulator
E4O06_08640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4O06_08660	COG1272	protein, Hemolysin III
E4O06_08665	COG1196	nuclear chromosome segregation
E4O06_08665	COG0741	lytic transglycosylase activity
E4O06_08665	COG0739	heme binding
E4O06_08690	COG0668	transmembrane transport
E4O06_08695	COG2197	response regulator
E4O06_08715	COG0542	response to heat
E4O06_08720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O06_08730	COG2855	membrane
E4O06_08740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O06_08745	COG1363	Peptidase, m42
E4O06_08760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O06_08780	COG0058	SHG alpha-glucan phosphorylase activity
E4O06_08800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O06_08805	COG0085	RNA polymerase activity
E4O06_08810	COG0222	ribosome binding
E4O06_08815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4O06_08820	COG0081	regulation of translation
E4O06_08825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O06_08830	COG0250	Participates in transcription elongation, termination and antitermination
E4O06_08835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O06_08845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O06_08875	COG1652	LysM domain
E4O06_08880	COG0726	polysaccharide deacetylase
E4O06_08895	COG2274	protein secretion by the type I secretion system
E4O06_08920	COG3620	sequence-specific DNA binding
E4O06_08930	COG0281	malic enzyme
E4O06_08950	COG2078	PFAM AMMECR1 domain protein
E4O06_08950	COG3885	ferrous iron binding
E4O06_08955	COG0666	response to abiotic stimulus
E4O06_08960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O06_08970	COG1129	ABC transporter
E4O06_08980	COG1131	(ABC) transporter
E4O06_09030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O06_09050	COG0425	Belongs to the sulfur carrier protein TusA family
E4O06_09065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O06_09080	COG0326	Molecular chaperone. Has ATPase activity
E4O06_09115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O06_09120	COG0534	Mate efflux family protein
E4O06_09125	COG0549	Belongs to the carbamate kinase family
E4O06_09130	COG1921	L-seryl-tRNASec selenium transferase activity
E4O06_09140	COG0322	excinuclease ABC activity
E4O06_09165	COG0848	biopolymer transport protein
E4O06_09170	COG0811	peptide transport
E4O06_09225	COG4104	PAAR repeat-containing protein
E4O06_09225	COG3209	COG3209 Rhs family protein
E4O06_09260	COG0210	DNA helicase
E4O06_09265	COG1132	(ABC) transporter
E4O06_09270	COG1132	(ABC) transporter
E4O06_09275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4O06_09285	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O06_09295	COG4786	Flagellar basal body rod
E4O06_09310	COG2084	Dehydrogenase
E4O06_09315	COG2116	formate transmembrane transporter activity
E4O06_09340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O06_09350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O06_09360	COG4608	Belongs to the ABC transporter superfamily
E4O06_09365	COG0444	Belongs to the ABC transporter superfamily
E4O06_09375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_09380	COG4174	ABC transporter (Permease)
E4O06_09395	COG0017	Asparaginyl-tRNA synthetase
E4O06_09400	COG1686	Belongs to the peptidase S11 family
E4O06_09405	COG2003	Belongs to the UPF0758 family
E4O06_09410	COG1040	competence protein
E4O06_09415	COG0018	arginyl-trna synthetase
E4O06_09420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O06_09435	COG1692	metallophosphoesterase
E4O06_09445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O06_09460	COG2089	acid synthase
E4O06_09465	COG5341	Protein conserved in bacteria
E4O06_09470	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4O06_09475	COG0584	glycerophosphoryl diester phosphodiesterase
E4O06_09480	COG1704	LemA family
E4O06_09485	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O06_09490	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O06_09495	COG3845	ABC transporter
E4O06_09500	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O06_09795	COG0148	phosphopyruvate hydratase activity
E4O06_09810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_09845	COG0318	PFAM AMP-dependent synthetase and ligase
E4O06_09850	COG0791	NLP P60 protein
E4O06_09860	COG3735	TraB family
E4O06_09870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_09875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O06_09890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_09895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O06_09905	COG0534	Mate efflux family protein
E4O06_09910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O06_09940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O06_09945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O06_09960	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_09990	COG1132	(ABC) transporter
E4O06_09995	COG1132	(ABC) transporter
E4O06_09995	COG2375	cellular response to nickel ion
E4O06_10010	COG1129	ABC transporter
E4O06_10040	COG3621	Patatin-like phospholipase
E4O06_10070	COG0210	DNA helicase
E4O06_10095	COG0335	large ribosomal subunit rRNA binding
E4O06_10100	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O06_10105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O06_10110	COG1837	Belongs to the UPF0109 family
E4O06_10115	COG0228	four-way junction DNA binding
E4O06_10150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O06_10155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O06_10160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O06_10195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O06_10200	COG1285	pathogenesis
E4O06_10230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O06_10255	COG0166	Belongs to the GPI family
E4O06_10260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O06_10275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4O06_10280	COG3706	GGDEF domain
E4O06_10285	COG3706	GGDEF domain
E4O06_10305	COG3290	protein histidine kinase activity
E4O06_10305	COG0840	transmembrane signaling receptor activity
E4O06_10310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4O06_10325	COG1362	aminopeptidase activity
E4O06_10330	COG1054	Belongs to the UPF0176 family
E4O06_10335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O06_10345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O06_10355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O06_10365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O06_10390	COG0724	RNA recognition motif
E4O06_10395	COG2264	protein methyltransferase activity
E4O06_10400	COG3314	Sporulation integral membrane protein YlbJ
E4O06_10405	COG0393	Putative heavy-metal-binding
E4O06_10410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O06_10415	COG2226	methyltransferase
E4O06_10420	COG0840	transmembrane signaling receptor activity
E4O06_10435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_10455	COG1477	protein flavinylation
E4O06_10460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O06_10465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O06_10475	COG0613	PHP domain protein
E4O06_10480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O06_10490	COG0330	HflC and HflK could
E4O06_10515	COG1131	(ABC) transporter
E4O06_10520	COG0351	phosphomethylpyrimidine kinase
E4O06_10525	COG0482	sulfurtransferase activity
E4O06_10540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O06_10545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O06_10550	COG1028	Short-chain dehydrogenase reductase Sdr
E4O06_10555	COG0629	single-stranded DNA binding
E4O06_10560	COG1862	Preprotein translocase
E4O06_10565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O06_10570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O06_10575	COG1104	cysteine desulfurase activity
E4O06_10585	COG0425	Belongs to the sulfur carrier protein TusA family
E4O06_10620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O06_10650	COG0719	Fe-S assembly protein
E4O06_10655	COG0396	ATPase activity
E4O06_10695	COG2211	Major facilitator Superfamily
E4O06_10730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O06_10735	COG0546	phosphoglycolate phosphatase activity
E4O06_10745	COG2239	Acts as a magnesium transporter
E4O06_10755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O06_10780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_10785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O06_10795	COG5001	Diguanylate cyclase
E4O06_10800	COG1162	GTPase activity
E4O06_10810	COG0084	hydrolase, TatD family'
E4O06_10815	COG3116	cell division
E4O06_10815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O06_10890	COG4974	Belongs to the 'phage' integrase family
E4O06_10900	COG0732	type I restriction modification DNA specificity domain
E4O06_10910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O06_10935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4O06_10950	COG4545	Glutaredoxin-related protein
E4O06_10955	COG0739	heme binding
E4O06_10960	COG2423	ornithine cyclodeaminase activity
E4O06_10965	COG1115	amino acid carrier protein
E4O06_10970	COG4166	transmembrane transport
E4O06_10975	COG1338	Plays a role in the flagellum-specific transport system
E4O06_10985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O06_10985	COG1776	CheC inhibitor of MCP methylation
E4O06_10990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O06_10995	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O06_11000	COG1360	Flagellar Motor Protein
E4O06_11005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O06_11020	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O06_11040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O06_11060	COG2201	protein-glutamate methylesterase activity
E4O06_11080	COG1137	ATPase activity
E4O06_11085	COG0193	aminoacyl-tRNA hydrolase activity
E4O06_11095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O06_11100	COG0601	transmembrane transport
E4O06_11105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_11110	COG0444	Belongs to the ABC transporter superfamily
E4O06_11115	COG4608	Belongs to the ABC transporter superfamily
E4O06_11125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O06_11150	COG0484	heat shock protein binding
E4O06_11155	COG0443	Heat shock 70 kDa protein
E4O06_11160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O06_11165	COG3177	Filamentation induced by cAMP protein fic
E4O06_11175	COG1120	ATPase activity
E4O06_11205	COG0534	Mate efflux family protein
E4O06_11225	COG1132	(ABC) transporter
E4O06_11230	COG0488	(ABC) transporter
E4O06_11250	COG1192	Involved in chromosome partitioning
E4O06_11255	COG1475	DNA binding
E4O06_11290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O06_11295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O06_11300	COG1028	Short-chain dehydrogenase reductase Sdr
E4O06_11310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O06_11365	COG0439	Biotin carboxylase
E4O06_11370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O06_11375	COG0825	malonyl-CoA metabolic process
E4O06_11380	COG2986	histidine ammonia-lyase
E4O06_11395	COG0701	Predicted permease
E4O06_11405	COG0714	Associated with various cellular activities
E4O06_11440	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O06_11445	COG0154	amidase activity
E4O06_11450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O06_11505	COG4104	PAAR repeat-containing protein
E4O06_11505	COG3209	COG3209 Rhs family protein
E4O06_11520	COG3209	COG3209 Rhs family protein
E4O06_11520	COG4104	PAAR repeat-containing protein
E4O06_11530	COG3209	COG3209 Rhs family protein
E4O06_11530	COG4104	PAAR repeat-containing protein
E4O06_11585	COG3209	COG3209 Rhs family protein
E4O06_11595	COG3209	COG3209 Rhs family protein
E4O06_11745	COG2887	Belongs to the helicase family. UvrD subfamily
E4O06_11750	COG0569	domain protein
E4O06_11755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O06_11760	COG1305	Transglutaminase-like
E4O06_11775	COG0215	cysteine-tRNA ligase activity
E4O06_11780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O06_11790	COG1373	ATPase (AAA superfamily
E4O06_11820	COG1506	peptidase
E4O06_11820	COG4946	Tricorn protease homolog
E4O06_11820	COG0823	Involved in the tonB-independent uptake of proteins
E4O06_11835	COG1104	cysteine desulfurase activity
E4O06_11840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O06_11845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O06_11880	COG0747	negative chemotaxis
E4O06_11885	COG4608	Belongs to the ABC transporter superfamily
E4O06_11890	COG0444	Belongs to the ABC transporter superfamily
E4O06_11895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_11910	COG1840	ABC-type Fe3 transport system, periplasmic component
E4O06_11915	COG4133	protoheme IX ABC transporter activity
E4O06_11925	COG3842	ATPase activity
E4O06_11930	COG0438	transferase activity, transferring glycosyl groups
E4O06_11950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4O06_11990	COG0728	peptidoglycan biosynthetic process
E4O06_11995	COG0786	glutamate:sodium symporter activity
E4O06_12005	COG0840	transmembrane signaling receptor activity
E4O06_12010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O06_12015	COG3588	fructose-bisphosphate aldolase
E4O06_12025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_12075	COG0569	domain protein
E4O06_12080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O06_12085	COG0363	glucosamine-6-phosphate deaminase activity
E4O06_12090	COG0628	permease
E4O06_12095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O06_12105	COG1902	pentaerythritol trinitrate reductase activity
E4O06_12110	COG1595	DNA-templated transcription, initiation
E4O06_12130	COG0534	Mate efflux family protein
E4O06_12135	COG1309	transcriptional regulator
E4O06_12145	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O06_12150	COG1518	maintenance of DNA repeat elements
E4O06_12165	COG0514	ATP-dependent DNA helicase (RecQ)
E4O06_12180	COG4536	flavin adenine dinucleotide binding
E4O06_12185	COG4536	flavin adenine dinucleotide binding
E4O06_12190	COG0714	Associated with various cellular activities
E4O06_12200	COG0569	domain protein
E4O06_12205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O06_12210	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O06_12255	COG1136	(ABC) transporter
E4O06_12270	COG0616	signal peptide processing
E4O06_12275	COG0012	GTP binding
E4O06_12285	COG0840	transmembrane signaling receptor activity
E4O06_12330	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O06_12345	COG3839	Belongs to the ABC transporter superfamily
E4O06_12350	COG4208	sulfate ABC transporter
E4O06_12375	COG0730	response to heat
E4O06_12440	COG1132	(ABC) transporter
E4O06_12450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4O06_12465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4O06_12485	COG1929	Belongs to the glycerate kinase type-1 family
E4O06_12490	COG3152	Membrane
E4O06_12495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O06_12595	COG1487	ribonuclease activity
E4O06_12630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O06_12635	COG0592	DNA-directed DNA polymerase activity
E4O06_12640	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O06_12645	COG3177	Filamentation induced by cAMP protein fic
E4O06_12660	COG1418	mRNA catabolic process
E4O06_12680	COG1968	undecaprenyl-diphosphatase activity
E4O06_12685	COG1674	ftsk spoiiie
E4O06_12690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O06_12695	COG3706	GGDEF domain
E4O06_12700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4O06_12705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_12765	COG0813	purine-nucleoside phosphorylase activity
E4O06_12795	COG0840	transmembrane signaling receptor activity
E4O06_12825	COG4221	oxidoreductase activity
E4O06_12830	COG0789	Transcriptional regulator
E4O06_12875	COG0789	Transcriptional regulator
E4O06_12890	COG3586	endonuclease activity
E4O06_12905	COG1132	(ABC) transporter
E4O06_12910	COG1132	(ABC) transporter
E4O06_12915	COG1129	ABC transporter
E4O06_12930	COG0419	ATPase involved in DNA repair
E4O06_12935	COG0420	3'-5' exonuclease activity
E4O06_12940	COG0840	transmembrane signaling receptor activity
E4O06_12940	COG3290	protein histidine kinase activity
E4O06_12950	COG1131	(ABC) transporter
E4O06_12960	COG1132	(ABC) transporter
E4O06_12965	COG2345	Transcriptional regulator
E4O06_12990	COG0500	methyltransferase
E4O06_13005	COG1132	(ABC) transporter
E4O06_13030	COG2186	Transcriptional regulator
E4O06_13040	COG1132	(ABC) transporter
E4O06_13050	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_13140	COG1373	ATPase (AAA superfamily
E4O06_13145	COG1473	amidohydrolase
E4O06_13150	COG4585	Histidine kinase
E4O06_13175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_13195	COG0800	Aldolase
E4O06_13200	COG1487	ribonuclease activity
E4O06_13220	COG0716	FMN binding
E4O06_13230	COG0540	Belongs to the ATCase OTCase family
E4O06_13230	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O06_13235	COG5001	Diguanylate cyclase
E4O06_13235	COG5002	protein histidine kinase activity
E4O06_13265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O06_13295	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O06_13310	COG1774	PSP1 C-terminal conserved region
E4O06_13315	COG1728	Protein conserved in bacteria
E4O06_13325	COG0739	heme binding
E4O06_13335	COG0366	Alpha amylase catalytic
E4O06_13345	COG1609	Transcriptional regulator
E4O06_13350	COG1129	ABC transporter
E4O06_13375	COG0543	2 iron, 2 sulfur cluster binding
E4O06_13385	COG4783	chaperone-mediated protein folding
E4O06_13390	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O06_13470	COG1592	Rubrerythrin
E4O06_13475	COG0514	ATP-dependent DNA helicase (RecQ)
E4O06_13485	COG1381	Involved in DNA repair and RecF pathway recombination
E4O06_13495	COG0343	queuine tRNA-ribosyltransferase activity
E4O06_13560	COG1695	Transcriptional regulator
E4O06_13570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O06_13590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O06_13600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O06_13620	COG1228	amidohydrolase
E4O06_13630	COG1987	bacterial-type flagellum assembly
E4O06_13635	COG1684	flagellar biosynthetic protein fliR
E4O06_13640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O06_13645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O06_13665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O06_13675	COG3328	transposase activity
E4O06_13720	COG0205	6-phosphofructokinase activity
E4O06_13735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O06_13750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O06_13755	COG1509	lysine 2,3-aminomutase activity
E4O06_13760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_13765	COG0826	peptidase U32
E4O06_13790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O06_13815	COG2801	Transposase and inactivated derivatives
E4O06_13930	COG4555	ABC transporter
E4O06_13945	COG0840	transmembrane signaling receptor activity
E4O06_13970	COG1151	hydroxylamine reductase activity
E4O06_13990	COG0577	efflux transmembrane transporter activity
E4O06_13990	COG1136	(ABC) transporter
E4O06_14025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O06_14055	COG0813	purine-nucleoside phosphorylase activity
E4O06_14065	COG0840	transmembrane signaling receptor activity
E4O06_14080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O06_14085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_14090	COG0037	tRNA processing
E4O06_14105	COG2235	arginine
E4O06_14115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O06_14125	COG2217	Heavy metal translocating P-type atpase
E4O06_14135	COG0494	nUDIX hydrolase
E4O06_14140	COG0783	Belongs to the Dps family
E4O06_14145	COG0450	alkyl hydroperoxide reductase
E4O06_14150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O06_14165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4O06_14170	COG1363	Peptidase, m42
E4O06_14180	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O06_14185	COG0423	glycine-tRNA ligase activity
E4O06_14205	COG1472	Belongs to the glycosyl hydrolase 3 family
E4O06_14260	COG0537	adenosine 5'-monophosphoramidase activity
E4O06_14280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4O06_14290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4O06_14295	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4O06_14295	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4O06_14300	COG0280	phosphate acetyltransferase
E4O06_14305	COG0457	Tetratricopeptide repeat
E4O06_14310	COG1393	Belongs to the ArsC family
E4O06_14315	COG0488	(ABC) transporter
E4O06_14350	COG0187	DNA topoisomerase II activity