locus-tag	class	description
E4O01_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O01_00025	COG0587	DNA-directed DNA polymerase activity
E4O01_00050	COG1132	(ABC) transporter
E4O01_00065	COG1132	(ABC) transporter
E4O01_00120	COG1473	amidohydrolase
E4O01_00125	COG0745	RESPONSE REGULATOR receiver
E4O01_00130	COG5002	protein histidine kinase activity
E4O01_00135	COG1136	(ABC) transporter
E4O01_00180	COG2378	regulation of single-species biofilm formation
E4O01_00195	COG2885	chlorophyll binding
E4O01_00200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O01_00200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O01_00200	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O01_00200	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O01_00210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4O01_00210	COG1747	RNA polymerase binding
E4O01_00235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4O01_00240	COG1419	protein localization to endoplasmic reticulum
E4O01_00255	COG1191	sigma factor activity
E4O01_00285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O01_00315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4O01_00320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O01_00325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O01_00340	COG0516	GMP reductase activity
E4O01_00345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O01_00365	COG0784	Response regulator, receiver
E4O01_00365	COG3437	response regulator, receiver
E4O01_00370	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O01_00425	COG1132	(ABC) transporter
E4O01_00430	COG0517	IMP dehydrogenase activity
E4O01_00430	COG4175	Glycine betaine
E4O01_00440	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O01_00445	COG0579	oxidoreductase
E4O01_00455	COG3177	Filamentation induced by cAMP protein fic
E4O01_00505	COG1086	Polysaccharide biosynthesis protein
E4O01_00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O01_00545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4O01_00570	COG0793	Belongs to the peptidase S41A family
E4O01_00570	COG3409	Peptidoglycan-binding domain 1 protein
E4O01_00580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O01_00630	COG3118	belongs to the thioredoxin family
E4O01_00640	COG1120	ATPase activity
E4O01_00645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O01_00660	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O01_00660	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O01_00665	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O01_00670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O01_00690	COG0732	type I restriction modification DNA specificity domain
E4O01_00710	COG0732	type I restriction modification DNA specificity domain
E4O01_00720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4O01_00725	COG0135	phosphoribosylanthranilate isomerase activity
E4O01_00730	COG1757	Na H antiporter
E4O01_00735	COG1120	ATPase activity
E4O01_00740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O01_00765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4O01_00770	COG0051	transcription antitermination factor activity, RNA binding
E4O01_00775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O01_00780	COG0088	Forms part of the polypeptide exit tunnel
E4O01_00785	COG0089	rRNA binding
E4O01_00790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O01_00795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O01_00800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O01_00805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O01_00810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O01_00815	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O01_00820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O01_00825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O01_00830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O01_00835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O01_00840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O01_00845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O01_00850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O01_00855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O01_00860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O01_00865	COG1841	ribosomal large subunit assembly
E4O01_00870	COG0200	Binds to the 23S rRNA
E4O01_00880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O01_00885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O01_00890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O01_00895	COG0202	RNA polymerase activity
E4O01_00900	COG0203	ribosomal protein L17
E4O01_00920	COG1254	Belongs to the acylphosphatase family
E4O01_00940	COG0584	glycerophosphoryl diester phosphodiesterase
E4O01_00960	COG2226	methyltransferase
E4O01_00965	COG1959	2 iron, 2 sulfur cluster binding
E4O01_00970	COG2910	NAD(P)H-binding
E4O01_00990	COG0840	transmembrane signaling receptor activity
E4O01_01085	COG1131	(ABC) transporter
E4O01_01100	COG0640	Transcriptional regulator
E4O01_01105	COG0840	transmembrane signaling receptor activity
E4O01_01115	COG4942	peptidase
E4O01_01135	COG0840	transmembrane signaling receptor activity
E4O01_01135	COG3290	protein histidine kinase activity
E4O01_01150	COG2207	Transcriptional regulator
E4O01_01155	COG2274	protein secretion by the type I secretion system
E4O01_01160	COG1132	(ABC) transporter
E4O01_01170	COG1741	Belongs to the pirin family
E4O01_01190	COG0515	serine threonine protein kinase
E4O01_01190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4O01_01215	COG1132	(ABC) transporter
E4O01_01225	COG1129	ABC transporter
E4O01_01245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O01_01250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O01_01255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O01_01270	COG1132	(ABC) transporter
E4O01_01275	COG4988	ABC transporter
E4O01_01285	COG1121	(ABC) transporter
E4O01_01290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O01_01320	COG0301	tRNA thio-modification
E4O01_01325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4O01_01330	COG4443	Transcriptional Coactivator p15 (PC4)
E4O01_01335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O01_01340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O01_01355	COG4657	Part of a membrane complex involved in electron transport
E4O01_01360	COG4660	Part of a membrane complex involved in electron transport
E4O01_01365	COG4659	FMN binding
E4O01_01370	COG4658	electron transport chain
E4O01_01375	COG4656	Part of a membrane complex involved in electron transport
E4O01_01385	COG2304	oxidoreductase activity
E4O01_01405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O01_01420	COG0840	transmembrane signaling receptor activity
E4O01_01435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O01_01450	COG0745	RESPONSE REGULATOR receiver
E4O01_01475	COG1187	pseudouridine synthase activity
E4O01_01480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O01_01490	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O01_01495	COG4988	ABC transporter
E4O01_01520	COG1362	aminopeptidase activity
E4O01_01525	COG0445	tRNA wobble uridine modification
E4O01_01550	COG2604	Protein of unknown function DUF115
E4O01_01565	COG1132	(ABC) transporter
E4O01_01590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O01_01600	COG4115	mRNA cleavage
E4O01_01615	COG0357	Ribosomal RNA small subunit methyltransferase G
E4O01_01620	COG1012	belongs to the aldehyde dehydrogenase family
E4O01_01640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O01_01655	COG0745	RESPONSE REGULATOR receiver
E4O01_01685	COG1573	uracil-dna glycosylase
E4O01_01690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O01_01715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4O01_01720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O01_01720	COG2890	protein-(glutamine-N5) methyltransferase activity
E4O01_01745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O01_01780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O01_01790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O01_01795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O01_01805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O01_01810	COG0706	membrane insertase activity
E4O01_01815	COG1847	R3H domain protein
E4O01_01825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O01_01840	COG0740	serine-type endopeptidase activity
E4O01_01850	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O01_01860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O01_01870	COG4585	Histidine kinase
E4O01_01885	COG1131	(ABC) transporter
E4O01_01890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O01_01910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O01_01925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O01_01935	COG1757	Na H antiporter
E4O01_01955	COG2376	Dihydroxyacetone kinase
E4O01_01960	COG2376	Dihydroxyacetone kinase
E4O01_01980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O01_01995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O01_02000	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O01_02005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O01_02025	COG1413	lyase activity
E4O01_02030	COG0424	maF-like protein
E4O01_02035	COG0052	Belongs to the universal ribosomal protein uS2 family
E4O01_02040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O01_02045	COG0233	cytoplasmic translational termination
E4O01_02050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O01_02055	COG0575	Belongs to the CDS family
E4O01_02060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O01_02065	COG0750	zinc metalloprotease
E4O01_02075	COG0495	leucyl-tRNA aminoacylation
E4O01_02090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O01_02100	COG2183	response to ionizing radiation
E4O01_02105	COG2703	oxygen carrier activity
E4O01_02115	COG1067	ATP-dependent peptidase activity
E4O01_02130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O01_02130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O01_02150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O01_02160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O01_02165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O01_02170	COG0571	ribonuclease III activity
E4O01_02175	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O01_02185	COG0617	tRNA 3'-terminal CCA addition
E4O01_02190	COG0598	Magnesium transport protein CorA
E4O01_02200	COG0840	transmembrane signaling receptor activity
E4O01_02205	COG0196	riboflavin kinase activity
E4O01_02210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O01_02215	COG1185	polyribonucleotide nucleotidyltransferase activity
E4O01_02220	COG0756	dUTP diphosphatase activity
E4O01_02235	COG4865	methylaspartate mutase activity
E4O01_02245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4O01_02250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O01_02255	COG1120	ATPase activity
E4O01_02260	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O01_02270	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O01_02290	COG0442	prolyl-tRNA aminoacylation
E4O01_02310	COG1879	ABC-type sugar transport system periplasmic component
E4O01_02315	COG1129	ABC transporter
E4O01_02320	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O01_02325	COG2226	methyltransferase
E4O01_02340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O01_02350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4O01_02365	COG2056	Na+-H+ antiporter family
E4O01_02370	COG1757	Na H antiporter
E4O01_02375	COG0697	spore germination
E4O01_02385	COG0626	cystathionine gamma-synthase activity
E4O01_02390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O01_02395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O01_02395	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O01_02395	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O01_02395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O01_02400	COG0564	pseudouridine synthase activity
E4O01_02405	COG0156	8-amino-7-oxononanoate synthase activity
E4O01_02415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O01_02425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4O01_02425	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4O01_02430	COG0739	heme binding
E4O01_02440	COG1475	DNA binding
E4O01_02445	COG1022	Amp-dependent synthetase and ligase
E4O01_02470	COG0671	phosphoesterase, PA-phosphatase related
E4O01_02475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O01_02535	COG2738	Putative neutral zinc metallopeptidase
E4O01_02550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O01_02565	COG1129	ABC transporter
E4O01_02605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O01_02610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O01_02620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O01_02625	COG1671	Belongs to the UPF0178 family
E4O01_02635	COG0741	lytic transglycosylase activity
E4O01_02635	COG1388	LysM domain
E4O01_02660	COG3681	Belongs to the UPF0597 family
E4O01_02665	COG4953	penicillin-binding protein 1C
E4O01_02670	COG1770	oligopeptidase
E4O01_02695	COG1114	Component of the transport system for branched-chain amino acids
E4O01_02710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O01_02735	COG2723	6-phospho-beta-galactosidase activity
E4O01_02750	COG0488	(ABC) transporter
E4O01_02780	COG1266	CAAX protease self-immunity
E4O01_02785	COG1266	CAAX protease self-immunity
E4O01_02825	COG2274	protein secretion by the type I secretion system
E4O01_02825	COG3271	cysteine-type peptidase activity
E4O01_02835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O01_02840	COG0632	four-way junction helicase activity
E4O01_02870	COG2056	Na+-H+ antiporter family
E4O01_02890	COG1136	(ABC) transporter
E4O01_02925	COG1122	ATPase activity
E4O01_02970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4O01_02980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O01_03015	COG1132	(ABC) transporter
E4O01_03035	COG2208	phosphoserine phosphatase activity
E4O01_03035	COG2770	Histidine kinase
E4O01_03040	COG1131	(ABC) transporter
E4O01_03060	COG0284	orotidine-5'-phosphate decarboxylase activity
E4O01_03080	COG0513	Belongs to the DEAD box helicase family
E4O01_03090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O01_03135	COG3876	Protein conserved in bacteria
E4O01_03140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O01_03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4O01_03160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O01_03165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O01_03170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O01_03175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O01_03180	COG0484	heat shock protein binding
E4O01_03185	COG0528	UMP kinase activity
E4O01_03190	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O01_03205	COG0539	negative regulation of cytoplasmic translation
E4O01_03210	COG2204	response regulator
E4O01_03215	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O01_03235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O01_03260	COG0251	oxidation-reduction process
E4O01_03265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O01_03270	COG1722	exodeoxyribonuclease VII activity
E4O01_03290	COG1918	ferrous iron import across plasma membrane
E4O01_03295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O01_03295	COG1918	ferrous iron import across plasma membrane
E4O01_03340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O01_03370	COG4166	transmembrane transport
E4O01_03385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4O01_03400	COG0552	protein localization to endoplasmic reticulum
E4O01_03410	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O01_03415	COG1136	(ABC) transporter
E4O01_03425	COG3880	PFAM UvrB UvrC protein
E4O01_03430	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O01_03440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O01_03445	COG0438	transferase activity, transferring glycosyl groups
E4O01_03455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O01_03465	COG0084	hydrolase, TatD family'
E4O01_03470	COG2885	chlorophyll binding
E4O01_03585	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O01_03595	COG1288	antiporter activity
E4O01_03620	COG1309	transcriptional regulator
E4O01_03630	COG1164	Oligoendopeptidase f
E4O01_03635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O01_03640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O01_03645	COG0606	chelatase, subunit chli
E4O01_03655	COG2885	chlorophyll binding
E4O01_03660	COG0433	COG0433 Predicted ATPase
E4O01_03670	COG0768	penicillin binding
E4O01_03675	COG2604	Protein of unknown function DUF115
E4O01_03700	COG1739	Uncharacterized protein family UPF0029
E4O01_03725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O01_03735	COG0330	HflC and HflK could
E4O01_03740	COG0330	HflC and HflK could
E4O01_03760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O01_03765	COG2088	sporulation resulting in formation of a cellular spore
E4O01_03775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O01_03780	COG0037	tRNA processing
E4O01_03785	COG0457	Tetratricopeptide repeat
E4O01_03790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O01_03805	COG0358	DNA primase activity
E4O01_03810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O01_03830	COG1077	Cell shape determining protein MreB Mrl
E4O01_03845	COG0768	penicillin binding
E4O01_03850	COG0772	Belongs to the SEDS family
E4O01_03885	COG2252	PERMEase
E4O01_03910	COG1794	racemase activity, acting on amino acids and derivatives
E4O01_03965	COG1715	Restriction endonuclease
E4O01_04105	COG0534	Mate efflux family protein
E4O01_04400	COG3039	Transposase
E4O01_04435	COG2226	methyltransferase
E4O01_04450	COG0406	alpha-ribazole phosphatase activity
E4O01_04470	COG1418	mRNA catabolic process
E4O01_04500	COG2033	superoxide reductase activity
E4O01_04505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O01_04515	COG2720	vancomycin resistance protein
E4O01_04520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O01_04530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O01_04535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O01_04550	COG0799	negative regulation of ribosome biogenesis
E4O01_04555	COG2059	Chromate
E4O01_04600	COG0739	heme binding
E4O01_04610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O01_04620	COG0708	Exodeoxyribonuclease III
E4O01_04625	COG0024	Methionine aminopeptidase
E4O01_04630	COG0484	heat shock protein binding
E4O01_04650	COG1233	COG1233 Phytoene dehydrogenase and related
E4O01_04655	COG1017	nitric oxide dioxygenase activity
E4O01_04655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4O01_04670	COG0617	tRNA 3'-terminal CCA addition
E4O01_04685	COG0519	Catalyzes the synthesis of GMP from XMP
E4O01_04695	COG0126	phosphoglycerate kinase activity
E4O01_04720	COG0268	Binds directly to 16S ribosomal RNA
E4O01_04740	COG1546	Belongs to the CinA family
E4O01_04740	COG1058	Belongs to the CinA family
E4O01_04860	COG0268	Binds directly to 16S ribosomal RNA
E4O01_04870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O01_04945	COG0588	phosphoglycerate mutase activity
E4O01_04965	COG1131	(ABC) transporter
E4O01_04975	COG0457	Tetratricopeptide repeat
E4O01_04980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O01_04985	COG2203	Gaf domain
E4O01_04985	COG3706	GGDEF domain
E4O01_04985	COG5001	Diguanylate cyclase
E4O01_04985	COG4251	negative regulation of phosphorylation
E4O01_04990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O01_04995	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O01_05000	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O01_05005	COG1394	ATPase activity, coupled to movement of substances
E4O01_05010	COG1269	ATP hydrolysis coupled proton transport
E4O01_05020	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O01_05025	COG0629	single-stranded DNA binding
E4O01_05030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O01_05035	COG0359	binds to the 23S rRNA
E4O01_05045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O01_05050	COG0740	serine-type endopeptidase activity
E4O01_05055	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O01_05075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O01_05085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O01_05105	COG0305	Participates in initiation and elongation during chromosome replication
E4O01_05115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O01_05120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O01_05125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O01_05145	COG1268	BioY protein
E4O01_05150	COG1122	ATPase activity
E4O01_05175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O01_05190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O01_05195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O01_05205	COG0237	dephospho-CoA kinase activity
E4O01_05210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O01_05210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O01_05210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O01_05230	COG3052	prosthetic group binding
E4O01_05250	COG1737	Transcriptional regulator
E4O01_05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O01_05265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O01_05280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4O01_05285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O01_05290	COG0509	glycine decarboxylation via glycine cleavage system
E4O01_05295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O01_05300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O01_05340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O01_05345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O01_05345	COG0493	'glutamate synthase
E4O01_05370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O01_05400	COG1051	belongs to the nudix hydrolase family
E4O01_05415	COG1051	belongs to the nudix hydrolase family
E4O01_05450	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O01_05455	COG0488	(ABC) transporter
E4O01_05460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4O01_05470	COG0835	chemotaxis
E4O01_05480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4O01_05500	COG0297	glycogen (starch) synthase activity
E4O01_05505	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O01_05510	COG2982	Protein involved in outer membrane biogenesis
E4O01_05535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O01_05540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O01_05545	COG0095	Lipoate-protein ligase
E4O01_05550	COG4608	Belongs to the ABC transporter superfamily
E4O01_05555	COG0444	Belongs to the ABC transporter superfamily
E4O01_05560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_05565	COG0601	transmembrane transport
E4O01_05570	COG0747	negative chemotaxis
E4O01_05575	COG0205	6-phosphofructokinase activity
E4O01_05580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O01_05585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O01_05590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O01_05610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O01_05625	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O01_05645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4O01_05650	COG0142	geranyltranstransferase activity
E4O01_05660	COG1692	metallophosphoesterase
E4O01_05690	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O01_05720	COG1136	(ABC) transporter
E4O01_05725	COG0577	efflux transmembrane transporter activity
E4O01_05740	COG3470	protein probably involved in high-affinity Fe2 transport
E4O01_05745	COG0672	)-iron permease
E4O01_05750	COG1136	(ABC) transporter
E4O01_05760	COG1760	l-serine dehydratase
E4O01_05765	COG1760	l-serine dehydratase
E4O01_05775	COG0254	rRNA binding
E4O01_05780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O01_05795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O01_05795	COG0574	Belongs to the PEP-utilizing enzyme family
E4O01_05805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O01_05860	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O01_05870	COG1196	nuclear chromosome segregation
E4O01_05880	COG2201	protein-glutamate methylesterase activity
E4O01_05890	COG0835	chemotaxis
E4O01_05895	COG2198	Histidine kinase
E4O01_05895	COG0643	Histidine kinase
E4O01_05910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O01_05915	COG0217	transcriptional regulatory protein
E4O01_05950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O01_05955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O01_05965	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O01_05965	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O01_05980	COG0802	atpase or kinase
E4O01_05990	COG2770	Histidine kinase
E4O01_05990	COG3437	response regulator, receiver
E4O01_05995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O01_06005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O01_06050	COG1136	(ABC) transporter
E4O01_06080	COG0745	RESPONSE REGULATOR receiver
E4O01_06080	COG2205	protein histidine kinase activity
E4O01_06080	COG3292	Two component regulator propeller
E4O01_06085	COG0745	RESPONSE REGULATOR receiver
E4O01_06095	COG2190	(PTS) system
E4O01_06095	COG2211	Major facilitator Superfamily
E4O01_06105	COG1193	negative regulation of DNA recombination
E4O01_06110	COG1162	GTPase activity
E4O01_06120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O01_06135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O01_06145	COG0124	histidyl-tRNA synthetase
E4O01_06160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O01_06165	COG0297	glycogen (starch) synthase activity
E4O01_06175	COG0706	membrane insertase activity
E4O01_06190	COG0706	membrane insertase activity
E4O01_06200	COG0463	Glycosyl transferase, family 2
E4O01_06205	COG3306	glycosyltransferase involved in LPS biosynthesis
E4O01_06210	COG1216	Glycosyl transferase, family 2
E4O01_06210	COG1442	glycosyl transferase family 8
E4O01_06245	COG1216	Glycosyl transferase, family 2
E4O01_06245	COG0463	Glycosyl transferase, family 2
E4O01_06270	COG2089	acid synthase
E4O01_06290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O01_06290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O01_06300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O01_06340	COG4310	Domain of unknown function (DUF2172)
E4O01_06350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O01_06355	COG1083	cytidylyl-transferase
E4O01_06365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O01_06370	COG1086	Polysaccharide biosynthesis protein
E4O01_06400	COG1373	ATPase (AAA superfamily
E4O01_06405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4O01_06410	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4O01_06410	COG0028	Belongs to the TPP enzyme family
E4O01_06430	COG0475	glutathione-regulated potassium exporter activity
E4O01_06455	COG1078	dGTPase activity
E4O01_06465	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O01_06475	COG0488	(ABC) transporter
E4O01_06490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O01_06490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O01_06495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O01_06505	COG0455	bacterial-type flagellum organization
E4O01_06535	COG4656	Part of a membrane complex involved in electron transport
E4O01_06550	COG0564	pseudouridine synthase activity
E4O01_06555	COG2217	Heavy metal translocating P-type atpase
E4O01_06560	COG0640	Transcriptional regulator
E4O01_06565	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O01_06585	COG2878	Part of a membrane complex involved in electron transport
E4O01_06590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O01_06595	COG0138	bifunctional purine biosynthesis protein purh
E4O01_06600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O01_06605	COG0653	protein targeting
E4O01_06610	COG1725	Transcriptional regulator
E4O01_06630	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O01_06640	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4O01_06645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O01_06650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O01_06660	COG2255	four-way junction helicase activity
E4O01_06665	COG1979	alcohol dehydrogenase
E4O01_06670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O01_06685	COG0731	radical SAM domain protein
E4O01_06700	COG1047	Peptidyl-prolyl cis-trans
E4O01_06735	COG0295	cytidine deaminase activity
E4O01_06755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O01_06785	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O01_06790	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O01_06795	COG3845	ABC transporter
E4O01_06800	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O01_06805	COG1234	tRNA 3'-trailer cleavage
E4O01_06825	COG0525	valine-tRNA ligase activity
E4O01_06830	COG0481	GTPase activity
E4O01_06835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O01_06845	COG0557	exoribonuclease II activity
E4O01_06850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O01_06850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O01_06855	COG0556	nucleotide-excision repair
E4O01_06860	COG1136	(ABC) transporter
E4O01_06895	COG1132	(ABC) transporter
E4O01_06900	COG1132	(ABC) transporter
E4O01_06900	COG2375	cellular response to nickel ion
E4O01_06905	COG2207	Transcriptional regulator
E4O01_06915	COG4555	ABC transporter
E4O01_06930	COG1136	(ABC) transporter
E4O01_06935	COG2274	protein secretion by the type I secretion system
E4O01_06935	COG3271	cysteine-type peptidase activity
E4O01_06945	COG0535	radical SAM domain protein
E4O01_06995	COG2378	regulation of single-species biofilm formation
E4O01_07005	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O01_07010	COG0475	glutathione-regulated potassium exporter activity
E4O01_07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O01_07025	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O01_07030	COG2204	response regulator
E4O01_07035	COG3852	Histidine kinase
E4O01_07040	COG0470	DNA polymerase III
E4O01_07045	COG1286	toxin biosynthetic process
E4O01_07060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O01_07065	COG1349	DNA-binding transcription factor activity
E4O01_07080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4O01_07100	COG0823	Involved in the tonB-independent uptake of proteins
E4O01_07110	COG1199	ATP-dependent helicase activity
E4O01_07115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O01_07130	COG0497	DNA recombination
E4O01_07150	COG1388	LysM domain
E4O01_07150	COG3942	CHAP domain
E4O01_07160	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O01_07165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O01_07170	COG0312	modulator of DNA gyrase
E4O01_07195	COG1122	ATPase activity
E4O01_07280	COG4254	PFAM FecR protein
E4O01_07320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4O01_07325	COG4475	Protein of unknown function (DUF436)
E4O01_07340	COG3039	Transposase
E4O01_07375	COG0840	transmembrane signaling receptor activity
E4O01_07380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O01_07385	COG3118	belongs to the thioredoxin family
E4O01_07400	COG4750	Nucleotidyl transferase
E4O01_07405	COG1115	amino acid carrier protein
E4O01_07430	COG2840	Smr protein MutS2
E4O01_07485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O01_07490	COG1480	7TM receptor with intracellular HD hydrolase
E4O01_07495	COG1702	phosphate starvation-inducible protein PhoH
E4O01_07510	COG0149	triose-phosphate isomerase activity
E4O01_07530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O01_07550	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O01_07555	COG1121	(ABC) transporter
E4O01_07560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O01_07565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O01_07580	COG0457	Tetratricopeptide repeat
E4O01_07590	COG1157	protein secretion by the type III secretion system
E4O01_07595	COG1317	bacterial-type flagellum organization
E4O01_07605	COG1766	The M ring may be actively involved in energy transduction
E4O01_07610	COG1677	Flagellar hook-basal body complex protein FliE
E4O01_07625	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4O01_07630	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O01_07635	COG4974	Belongs to the 'phage' integrase family
E4O01_07640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4O01_07640	COG0551	DNA topoisomerase type I activity
E4O01_07645	COG0758	DNA mediated transformation
E4O01_07660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O01_07675	COG0772	Belongs to the SEDS family
E4O01_07680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4O01_07690	COG0275	rRNA processing
E4O01_07695	COG2001	Belongs to the MraZ family
E4O01_07700	COG1505	serine-type exopeptidase activity
E4O01_07735	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O01_07745	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O01_07785	COG0459	protein refolding
E4O01_07800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O01_07805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O01_07845	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O01_07865	COG3033	Beta-eliminating lyase
E4O01_07870	COG0563	adenylate kinase activity
E4O01_07890	COG0779	Required for maturation of 30S ribosomal subunits
E4O01_07900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O01_07905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O01_07910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O01_07930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_07940	COG0747	negative chemotaxis
E4O01_07970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4O01_07975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O01_07985	COG3330	Domain of unknown function (DUF4912)
E4O01_08000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O01_08010	COG3706	GGDEF domain
E4O01_08015	COG1102	Psort location Cytoplasmic, score
E4O01_08020	COG1561	YicC-like family, N-terminal region
E4O01_08030	COG0285	dihydrofolate synthase activity
E4O01_08050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4O01_08055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O01_08065	COG4608	Belongs to the ABC transporter superfamily
E4O01_08070	COG0444	Belongs to the ABC transporter superfamily
E4O01_08075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_08080	COG0601	transmembrane transport
E4O01_08095	COG0601	transmembrane transport
E4O01_08100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_08105	COG0444	Belongs to the ABC transporter superfamily
E4O01_08110	COG4608	Belongs to the ABC transporter superfamily
E4O01_08130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O01_08130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O01_08160	COG0534	Mate efflux family protein
E4O01_08165	COG0840	transmembrane signaling receptor activity
E4O01_08180	COG2801	Transposase and inactivated derivatives
E4O01_08215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O01_08220	COG0049	tRNA binding
E4O01_08225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O01_08255	COG0629	single-stranded DNA binding
E4O01_08470	COG3645	SOS response
E4O01_08495	COG2832	Protein of unknown function (DUF454)
E4O01_08500	COG3142	Participates in the control of copper homeostasis
E4O01_08525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O01_08560	COG0737	Belongs to the 5'-nucleotidase family
E4O01_08575	COG0826	peptidase U32
E4O01_08585	COG1132	(ABC) transporter
E4O01_08590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O01_08605	COG0101	tRNA pseudouridine synthase activity
E4O01_08615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O01_08620	COG1639	'signal transduction protein
E4O01_08635	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4O01_08640	COG0577	efflux transmembrane transporter activity
E4O01_08640	COG1136	(ABC) transporter
E4O01_08645	COG1136	(ABC) transporter
E4O01_08660	COG3956	TIGRFAM MazG family protein
E4O01_08665	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O01_08670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O01_08680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O01_08680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O01_08685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O01_08700	COG0668	transmembrane transport
E4O01_08715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O01_08720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O01_08725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O01_08740	COG0792	nuclease activity
E4O01_08755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O01_08775	COG3604	Transcriptional regulator
E4O01_08780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4O01_08800	COG1272	protein, Hemolysin III
E4O01_08805	COG1196	nuclear chromosome segregation
E4O01_08805	COG0741	lytic transglycosylase activity
E4O01_08805	COG0739	heme binding
E4O01_08830	COG0668	transmembrane transport
E4O01_08835	COG2197	response regulator
E4O01_08855	COG0542	response to heat
E4O01_08860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O01_08870	COG2855	membrane
E4O01_08880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O01_08885	COG1363	Peptidase, m42
E4O01_08900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O01_08920	COG0058	SHG alpha-glucan phosphorylase activity
E4O01_08940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O01_08945	COG0085	RNA polymerase activity
E4O01_08950	COG0222	ribosome binding
E4O01_08955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4O01_08960	COG0081	regulation of translation
E4O01_08965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O01_08970	COG0250	Participates in transcription elongation, termination and antitermination
E4O01_08975	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O01_08985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O01_09015	COG1652	LysM domain
E4O01_09020	COG0726	polysaccharide deacetylase
E4O01_09035	COG2274	protein secretion by the type I secretion system
E4O01_09055	COG3620	sequence-specific DNA binding
E4O01_09065	COG0281	malic enzyme
E4O01_09085	COG2078	PFAM AMMECR1 domain protein
E4O01_09085	COG3885	ferrous iron binding
E4O01_09090	COG0666	response to abiotic stimulus
E4O01_09095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O01_09105	COG1129	ABC transporter
E4O01_09115	COG1131	(ABC) transporter
E4O01_09165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O01_09185	COG0425	Belongs to the sulfur carrier protein TusA family
E4O01_09200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O01_09215	COG0326	Molecular chaperone. Has ATPase activity
E4O01_09250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O01_09255	COG0534	Mate efflux family protein
E4O01_09260	COG0549	Belongs to the carbamate kinase family
E4O01_09265	COG1921	L-seryl-tRNASec selenium transferase activity
E4O01_09275	COG0322	excinuclease ABC activity
E4O01_09300	COG0848	biopolymer transport protein
E4O01_09305	COG0811	peptide transport
E4O01_09360	COG3209	COG3209 Rhs family protein
E4O01_09360	COG4104	PAAR repeat-containing protein
E4O01_09395	COG0210	DNA helicase
E4O01_09400	COG1132	(ABC) transporter
E4O01_09405	COG1132	(ABC) transporter
E4O01_09410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4O01_09420	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O01_09430	COG4786	Flagellar basal body rod
E4O01_09445	COG2084	Dehydrogenase
E4O01_09450	COG2116	formate transmembrane transporter activity
E4O01_09475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O01_09485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O01_09495	COG4608	Belongs to the ABC transporter superfamily
E4O01_09500	COG0444	Belongs to the ABC transporter superfamily
E4O01_09510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_09515	COG4174	ABC transporter (Permease)
E4O01_09530	COG0017	Asparaginyl-tRNA synthetase
E4O01_09535	COG1686	Belongs to the peptidase S11 family
E4O01_09540	COG2003	Belongs to the UPF0758 family
E4O01_09545	COG1040	competence protein
E4O01_09550	COG0018	arginyl-trna synthetase
E4O01_09555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O01_09570	COG1692	metallophosphoesterase
E4O01_09580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O01_09595	COG2089	acid synthase
E4O01_09600	COG5341	Protein conserved in bacteria
E4O01_09605	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4O01_09610	COG0584	glycerophosphoryl diester phosphodiesterase
E4O01_09615	COG1704	LemA family
E4O01_09620	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O01_09625	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O01_09630	COG3845	ABC transporter
E4O01_09635	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O01_09950	COG0148	phosphopyruvate hydratase activity
E4O01_09965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O01_09995	COG0318	PFAM AMP-dependent synthetase and ligase
E4O01_10000	COG0791	NLP P60 protein
E4O01_10010	COG3735	TraB family
E4O01_10020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O01_10025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O01_10040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O01_10045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O01_10055	COG0534	Mate efflux family protein
E4O01_10060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O01_10090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O01_10095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O01_10110	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O01_10140	COG1132	(ABC) transporter
E4O01_10145	COG2375	cellular response to nickel ion
E4O01_10145	COG1132	(ABC) transporter
E4O01_10160	COG1129	ABC transporter
E4O01_10190	COG3621	Patatin-like phospholipase
E4O01_10220	COG0210	DNA helicase
E4O01_10245	COG0335	large ribosomal subunit rRNA binding
E4O01_10250	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O01_10255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O01_10260	COG1837	Belongs to the UPF0109 family
E4O01_10265	COG0228	four-way junction DNA binding
E4O01_10300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O01_10305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O01_10310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O01_10340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O01_10345	COG1285	pathogenesis
E4O01_10375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O01_10400	COG0166	Belongs to the GPI family
E4O01_10405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O01_10420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4O01_10425	COG3706	GGDEF domain
E4O01_10430	COG3706	GGDEF domain
E4O01_10450	COG3290	protein histidine kinase activity
E4O01_10450	COG0840	transmembrane signaling receptor activity
E4O01_10455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4O01_10470	COG1362	aminopeptidase activity
E4O01_10475	COG1054	Belongs to the UPF0176 family
E4O01_10480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O01_10490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O01_10500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O01_10510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O01_10535	COG0724	RNA recognition motif
E4O01_10540	COG2264	protein methyltransferase activity
E4O01_10545	COG3314	Sporulation integral membrane protein YlbJ
E4O01_10550	COG0393	Putative heavy-metal-binding
E4O01_10555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O01_10560	COG2226	methyltransferase
E4O01_10565	COG0840	transmembrane signaling receptor activity
E4O01_10580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O01_10600	COG1477	protein flavinylation
E4O01_10605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O01_10610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O01_10620	COG0613	PHP domain protein
E4O01_10625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O01_10635	COG0330	HflC and HflK could
E4O01_10660	COG1131	(ABC) transporter
E4O01_10665	COG0351	phosphomethylpyrimidine kinase
E4O01_10670	COG0482	sulfurtransferase activity
E4O01_10685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O01_10690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O01_10695	COG1028	Short-chain dehydrogenase reductase Sdr
E4O01_10700	COG0629	single-stranded DNA binding
E4O01_10705	COG1862	Preprotein translocase
E4O01_10710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O01_10715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O01_10720	COG1104	cysteine desulfurase activity
E4O01_10730	COG0425	Belongs to the sulfur carrier protein TusA family
E4O01_10765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O01_10790	COG0719	Fe-S assembly protein
E4O01_10795	COG0396	ATPase activity
E4O01_10835	COG2211	Major facilitator Superfamily
E4O01_10870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O01_10875	COG0546	phosphoglycolate phosphatase activity
E4O01_10885	COG2239	Acts as a magnesium transporter
E4O01_10895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O01_10920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O01_10925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O01_10935	COG5001	Diguanylate cyclase
E4O01_10940	COG1162	GTPase activity
E4O01_10950	COG0084	hydrolase, TatD family'
E4O01_10955	COG3116	cell division
E4O01_10955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O01_11030	COG4974	Belongs to the 'phage' integrase family
E4O01_11040	COG0732	type I restriction modification DNA specificity domain
E4O01_11050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O01_11075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4O01_11090	COG4545	Glutaredoxin-related protein
E4O01_11095	COG0739	heme binding
E4O01_11100	COG2423	ornithine cyclodeaminase activity
E4O01_11105	COG1115	amino acid carrier protein
E4O01_11110	COG4166	transmembrane transport
E4O01_11115	COG1338	Plays a role in the flagellum-specific transport system
E4O01_11125	COG1776	CheC inhibitor of MCP methylation
E4O01_11125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O01_11130	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O01_11135	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O01_11140	COG1360	Flagellar Motor Protein
E4O01_11145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O01_11160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O01_11180	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O01_11200	COG2201	protein-glutamate methylesterase activity
E4O01_11220	COG1137	ATPase activity
E4O01_11225	COG0193	aminoacyl-tRNA hydrolase activity
E4O01_11235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O01_11240	COG0601	transmembrane transport
E4O01_11245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_11250	COG0444	Belongs to the ABC transporter superfamily
E4O01_11255	COG4608	Belongs to the ABC transporter superfamily
E4O01_11265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O01_11290	COG0484	heat shock protein binding
E4O01_11295	COG0443	Heat shock 70 kDa protein
E4O01_11300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O01_11305	COG3177	Filamentation induced by cAMP protein fic
E4O01_11315	COG1120	ATPase activity
E4O01_11345	COG0534	Mate efflux family protein
E4O01_11365	COG1132	(ABC) transporter
E4O01_11370	COG0488	(ABC) transporter
E4O01_11390	COG1192	Involved in chromosome partitioning
E4O01_11395	COG1475	DNA binding
E4O01_11430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O01_11435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O01_11440	COG1028	Short-chain dehydrogenase reductase Sdr
E4O01_11450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O01_11505	COG0439	Biotin carboxylase
E4O01_11510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O01_11515	COG0825	malonyl-CoA metabolic process
E4O01_11520	COG2986	histidine ammonia-lyase
E4O01_11535	COG0701	Predicted permease
E4O01_11545	COG0714	Associated with various cellular activities
E4O01_11580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O01_11585	COG0154	amidase activity
E4O01_11590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O01_11645	COG4104	PAAR repeat-containing protein
E4O01_11645	COG3209	COG3209 Rhs family protein
E4O01_11660	COG3209	COG3209 Rhs family protein
E4O01_11660	COG4104	PAAR repeat-containing protein
E4O01_11670	COG3209	COG3209 Rhs family protein
E4O01_11670	COG4104	PAAR repeat-containing protein
E4O01_11725	COG3209	COG3209 Rhs family protein
E4O01_11735	COG3209	COG3209 Rhs family protein
E4O01_11885	COG2887	Belongs to the helicase family. UvrD subfamily
E4O01_11890	COG0569	domain protein
E4O01_11895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O01_11900	COG1305	Transglutaminase-like
E4O01_11915	COG0215	cysteine-tRNA ligase activity
E4O01_11920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O01_11930	COG1373	ATPase (AAA superfamily
E4O01_11960	COG4946	Tricorn protease homolog
E4O01_11960	COG1506	peptidase
E4O01_11960	COG0823	Involved in the tonB-independent uptake of proteins
E4O01_11975	COG1104	cysteine desulfurase activity
E4O01_11980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O01_11985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O01_12020	COG0747	negative chemotaxis
E4O01_12025	COG4608	Belongs to the ABC transporter superfamily
E4O01_12030	COG0444	Belongs to the ABC transporter superfamily
E4O01_12035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O01_12050	COG1840	ABC-type Fe3 transport system, periplasmic component
E4O01_12055	COG4133	protoheme IX ABC transporter activity
E4O01_12065	COG3842	ATPase activity
E4O01_12070	COG0438	transferase activity, transferring glycosyl groups
E4O01_12090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4O01_12130	COG0728	peptidoglycan biosynthetic process
E4O01_12135	COG0786	glutamate:sodium symporter activity
E4O01_12145	COG0840	transmembrane signaling receptor activity
E4O01_12150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O01_12155	COG3588	fructose-bisphosphate aldolase
E4O01_12165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O01_12215	COG0569	domain protein
E4O01_12220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O01_12225	COG0363	glucosamine-6-phosphate deaminase activity
E4O01_12230	COG0628	permease
E4O01_12235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O01_12245	COG1902	pentaerythritol trinitrate reductase activity
E4O01_12250	COG1595	DNA-templated transcription, initiation
E4O01_12270	COG0534	Mate efflux family protein
E4O01_12275	COG1309	transcriptional regulator
E4O01_12285	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O01_12290	COG1518	maintenance of DNA repeat elements
E4O01_12305	COG0514	ATP-dependent DNA helicase (RecQ)
E4O01_12320	COG4536	flavin adenine dinucleotide binding
E4O01_12325	COG4536	flavin adenine dinucleotide binding
E4O01_12330	COG0714	Associated with various cellular activities
E4O01_12340	COG0569	domain protein
E4O01_12345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O01_12350	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O01_12395	COG1136	(ABC) transporter
E4O01_12410	COG0616	signal peptide processing
E4O01_12415	COG0012	GTP binding
E4O01_12425	COG0840	transmembrane signaling receptor activity
E4O01_12470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O01_12485	COG3839	Belongs to the ABC transporter superfamily
E4O01_12490	COG4208	sulfate ABC transporter
E4O01_12515	COG0730	response to heat
E4O01_12580	COG1132	(ABC) transporter
E4O01_12590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4O01_12605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4O01_12625	COG1929	Belongs to the glycerate kinase type-1 family
E4O01_12630	COG3152	Membrane
E4O01_12635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O01_12735	COG1487	ribonuclease activity
E4O01_12770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O01_12775	COG0592	DNA-directed DNA polymerase activity
E4O01_12780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O01_12785	COG3177	Filamentation induced by cAMP protein fic
E4O01_12800	COG1418	mRNA catabolic process
E4O01_12820	COG1968	undecaprenyl-diphosphatase activity
E4O01_12825	COG1674	ftsk spoiiie
E4O01_12830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O01_12835	COG3706	GGDEF domain
E4O01_12840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4O01_12845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O01_12900	COG0813	purine-nucleoside phosphorylase activity
E4O01_12930	COG0840	transmembrane signaling receptor activity
E4O01_12960	COG4221	oxidoreductase activity
E4O01_12965	COG0789	Transcriptional regulator
E4O01_13010	COG0789	Transcriptional regulator
E4O01_13025	COG3586	endonuclease activity
E4O01_13040	COG1132	(ABC) transporter
E4O01_13045	COG1132	(ABC) transporter
E4O01_13050	COG1129	ABC transporter
E4O01_13065	COG0419	ATPase involved in DNA repair
E4O01_13070	COG0420	3'-5' exonuclease activity
E4O01_13075	COG3290	protein histidine kinase activity
E4O01_13075	COG0840	transmembrane signaling receptor activity
E4O01_13085	COG1131	(ABC) transporter
E4O01_13095	COG1132	(ABC) transporter
E4O01_13100	COG2345	Transcriptional regulator
E4O01_13130	COG0500	methyltransferase
E4O01_13145	COG1132	(ABC) transporter
E4O01_13170	COG2186	Transcriptional regulator
E4O01_13180	COG1132	(ABC) transporter
E4O01_13190	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O01_13280	COG1373	ATPase (AAA superfamily
E4O01_13285	COG1473	amidohydrolase
E4O01_13290	COG4585	Histidine kinase
E4O01_13315	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O01_13335	COG0800	Aldolase
E4O01_13340	COG1487	ribonuclease activity
E4O01_13360	COG0716	FMN binding
E4O01_13370	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O01_13370	COG0540	Belongs to the ATCase OTCase family
E4O01_13375	COG5002	protein histidine kinase activity
E4O01_13375	COG5001	Diguanylate cyclase
E4O01_13405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O01_13435	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O01_13450	COG1774	PSP1 C-terminal conserved region
E4O01_13455	COG1728	Protein conserved in bacteria
E4O01_13465	COG0739	heme binding
E4O01_13475	COG0366	Alpha amylase catalytic
E4O01_13485	COG1609	Transcriptional regulator
E4O01_13490	COG1129	ABC transporter
E4O01_13515	COG0543	2 iron, 2 sulfur cluster binding
E4O01_13525	COG4783	chaperone-mediated protein folding
E4O01_13530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O01_13610	COG1592	Rubrerythrin
E4O01_13615	COG0514	ATP-dependent DNA helicase (RecQ)
E4O01_13625	COG1381	Involved in DNA repair and RecF pathway recombination
E4O01_13635	COG0343	queuine tRNA-ribosyltransferase activity
E4O01_13700	COG1695	Transcriptional regulator
E4O01_13710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O01_13730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O01_13740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O01_13760	COG1228	amidohydrolase
E4O01_13770	COG1987	bacterial-type flagellum assembly
E4O01_13775	COG1684	flagellar biosynthetic protein fliR
E4O01_13780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O01_13785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O01_13805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O01_13815	COG3328	transposase activity
E4O01_13860	COG0205	6-phosphofructokinase activity
E4O01_13875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O01_13890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O01_13895	COG1509	lysine 2,3-aminomutase activity
E4O01_13900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O01_13905	COG0826	peptidase U32
E4O01_13930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O01_13955	COG2801	Transposase and inactivated derivatives
E4O01_14070	COG4555	ABC transporter
E4O01_14085	COG0840	transmembrane signaling receptor activity
E4O01_14110	COG1151	hydroxylamine reductase activity
E4O01_14130	COG0577	efflux transmembrane transporter activity
E4O01_14130	COG1136	(ABC) transporter
E4O01_14165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O01_14195	COG0813	purine-nucleoside phosphorylase activity
E4O01_14205	COG0840	transmembrane signaling receptor activity
E4O01_14220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O01_14225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O01_14230	COG0037	tRNA processing
E4O01_14245	COG2235	arginine
E4O01_14255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O01_14265	COG2217	Heavy metal translocating P-type atpase
E4O01_14275	COG0494	nUDIX hydrolase
E4O01_14280	COG0783	Belongs to the Dps family
E4O01_14285	COG0450	alkyl hydroperoxide reductase
E4O01_14290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O01_14305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4O01_14310	COG1363	Peptidase, m42
E4O01_14320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O01_14325	COG0423	glycine-tRNA ligase activity
E4O01_14345	COG1472	Belongs to the glycosyl hydrolase 3 family
E4O01_14400	COG0537	adenosine 5'-monophosphoramidase activity
E4O01_14420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4O01_14430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4O01_14435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4O01_14435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4O01_14440	COG0280	phosphate acetyltransferase
E4O01_14445	COG0457	Tetratricopeptide repeat
E4O01_14450	COG1393	Belongs to the ArsC family
E4O01_14455	COG0488	(ABC) transporter
E4O01_14490	COG0187	DNA topoisomerase II activity