locus-tag class description JO41_00055 ENOG4108IY2 MazG family JO41_00080 ENOG4105CIH Imidazole acetol-phosphate transaminase JO41_00105 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) JO41_00115 ENOG4105J3I JO41_00120 ENOG4105F8J Adenylate Guanylate cyclase JO41_00125 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JO41_00130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) JO41_00135 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JO41_00145 ENOG4105CT4 transporter JO41_00165 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JO41_00170 ENOG41068UM RNA Polymerase JO41_00195 ENOG4105K5M 30s ribosomal protein S16 JO41_00200 ENOG4105VB6 UPF0109 protein JO41_00205 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) JO41_00210 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) JO41_00215 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) JO41_00235 ENOG41082I4 UPF0102 protein JO41_00250 ENOG4105C8T Leucyl-tRNA synthetase JO41_00260 ENOG4105VCQ rubredoxin JO41_00275 ENOG4105CG6 trap dicarboxylate transporter dctm subunit JO41_00295 ENOG4105C8Q Methyl-accepting chemotaxis JO41_00305 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) JO41_00320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) JO41_00325 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) JO41_00330 ENOG4105SXG JO41_00345 ENOG4105DG6 mannose-6-phosphate isomerase JO41_00350 ENOG4105C25 Primosomal protein n' JO41_00355 ENOG4108UN4 phage SPO1 DNA polymerase-related protein JO41_00365 ENOG4105RD7 BadF BadG BcrA BcrD JO41_00370 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate JO41_00385 ENOG4105XN3 extracellular solute-binding protein family 1 JO41_00390 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component JO41_00395 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component JO41_00400 ENOG4105G9E JO41_00405 ENOG4108J59 Extracellular solute-binding protein, family 5 JO41_00415 ENOG41067SE Tetr family transcriptional regulator JO41_00430 ENOG4105CFC Transporter JO41_00440 ENOG4105XN3 extracellular solute-binding protein family 1 JO41_00475 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) JO41_00480 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin JO41_00495 ENOG4105C22 threonyL-tRNA synthetase JO41_00500 ENOG4108Z66 YbaK ebsC protein JO41_00505 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) JO41_00515 ENOG4105CKI cobalamin synthesis protein JO41_00520 ENOG4108UT2 hemolysin iii JO41_00525 ENOG41082DI 50s ribosomal protein l31 JO41_00530 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) JO41_00545 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) JO41_00550 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) JO41_00555 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) JO41_00565 ENOG4107NGC Flagellar filament outer layer protein JO41_00575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase JO41_00600 ENOG4108ZVA radical SAM domain protein JO41_00615 ENOG4107Z9R response regulator JO41_00625 ENOG4105YFD chemotaxis, protein JO41_00630 ENOG4105CBS Chea signal transduction histidine kinase JO41_00635 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination JO41_00640 ENOG4105Q1T In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination JO41_00645 ENOG41080XV Thioredoxin JO41_00655 ENOG4105DJ0 Poly(A) Polymerase JO41_00660 ENOG4105CG6 trap dicarboxylate transporter dctm subunit JO41_00670 ENOG41081IW Inherit from COG: Membrane JO41_00680 ENOG410830R acetyltransferase JO41_00685 ENOG4107QKZ Ompa motb domain protein JO41_00690 ENOG4105D3R alkyl hydroperoxide reductase JO41_00695 ENOG4105K4H Nlp p60 protein JO41_00700 ENOG4105DUM transcriptional regulator, lysR family JO41_00705 ENOG4107QIV Cytochrome c biogenesis protein JO41_00750 ENOG4105D5G Transposase JO41_00770 ENOG4105BZ4 penicillin-binding protein JO41_00800 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component JO41_00815 ENOG41089UC methyltransferase, type 11 JO41_00820 ENOG4105C0D helicase JO41_00835 ENOG41080VC Galactokinase (EC 2.7.1.6) JO41_00850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO41_00875 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) JO41_00885 ENOG4107ZYR domain protein JO41_00890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) JO41_00915 ENOG4105DAN ATP-dependent protease JO41_00980 ENOG4106N3A copper homeostasis protein cutc JO41_01005 ENOG4106SUR Protein of unknown function DUF115 JO41_01015 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) JO41_01035 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A JO41_01050 ENOG4105CMG Carbohydrate kinase JO41_01075 ENOG4105VDM plasmid maintenance system antidote protein, xre family JO41_01080 ENOG41080ET plasmid maintenance system killer protein JO41_01110 ENOG4105EUJ GTP cyclohydrolase i JO41_01115 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) JO41_01120 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) JO41_01135 ENOG4105EI2 Pseudouridine synthase JO41_01150 ENOG4107YM1 mraZ protein JO41_01155 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) JO41_01165 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) JO41_01170 ENOG4105CNI cell division protein FtsW JO41_01175 ENOG4108APS Essential cell division protein (By similarity) JO41_01180 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) JO41_01185 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) JO41_01195 ENOG4105C2W permease JO41_01210 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) JO41_01235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JO41_01240 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) JO41_01245 ENOG4105D82 Glutamate dehydrogenase JO41_01275 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) JO41_01310 ENOG4105CTZ aminopeptidase c JO41_01320 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) JO41_01325 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) JO41_01330 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) JO41_01335 ENOG4108ZC9 flagellar basal-body rod protein flgc JO41_01340 ENOG41069WH flagellar hook-basal body complex JO41_01345 ENOG4107U2N Flagellar M-ring protein JO41_01350 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO41_01355 ENOG4105W2B Flagellar assembly protein JO41_01360 ENOG4108JIR Flagellum-specific ATP synthase JO41_01385 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) JO41_01390 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO41_01395 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) JO41_01400 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) JO41_01405 ENOG4105DFA alanine racemase domain protein JO41_01440 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) JO41_01445 ENOG4105EM7 Selenocysteine-specific translation elongation factor JO41_01450 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO41_01460 ENOG4107GFK fumarate JO41_01480 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) JO41_01495 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component JO41_01500 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component JO41_01510 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) JO41_01515 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JO41_01520 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) JO41_01525 ENOG4105F4G Membrane JO41_01530 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) JO41_01535 ENOG4105CE4 GlcNAc 6-P deacetylase JO41_01550 ENOG4105C5H ABC transporter JO41_01570 ENOG4105Y6R JO41_01585 ENOG4105F8V Hydrolase, tatD family JO41_01590 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) JO41_01595 ENOG4105D01 (LipO)protein JO41_01610 ENOG4105CJ2 (LipO)protein JO41_01620 ENOG4105WYW fructose-bisphosphate aldolase JO41_01645 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) JO41_01675 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) JO41_01680 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JO41_01700 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) JO41_01710 ENOG4105CU9 asparagine synthetase A JO41_01740 ENOG4105CDY transcriptional regulatory protein JO41_01750 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) JO41_01755 ENOG4105E89 ABC transporter JO41_01775 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) JO41_01780 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) JO41_01785 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO41_01790 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO41_01795 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) JO41_01800 ENOG4108VZM 50s ribosomal protein L10 JO41_01805 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) JO41_01810 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) JO41_01815 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) JO41_01830 ENOG41084ED 50S ribosomal protein L33 JO41_01845 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) JO41_01850 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) JO41_01865 ENOG4105SFS phosphoesterase RecJ domain protein JO41_01875 ENOG41084P6 50S ribosomal protein l28 JO41_01905 ENOG4108JJB ABC transporter JO41_01920 ENOG4105EMN RNA polymerase sigma factor JO41_01940 ENOG4105D07 Signal peptide peptidase, SppA JO41_01945 ENOG4108JQ7 (ABC) transporter JO41_01955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO41_01960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JO41_01965 ENOG4107QSI ABC, transporter JO41_01975 ENOG4105CFP Peptidase U32 JO41_01985 ENOG4105CB5 ATP-dependent DNA helicase recG JO41_02145 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the JO41_02280 ENOG4105C9U ATP-dependent DNA helicase RecQ JO41_02305 ENOG4105DR5 peptidase JO41_02320 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) JO41_02330 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane JO41_02350 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) JO41_02360 ENOG4105DR5 peptidase JO41_02375 ENOG4105MA4 psp1 domain protein JO41_02390 ENOG4105E2X shikimate dehydrogenase JO41_02395 ENOG4105E66 phosphoriboisomerase A JO41_02400 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) JO41_02425 ENOG41067XK integral membrane protein JO41_02435 ENOG4105CYC Transferase JO41_02440 ENOG4105E39 Enoyl-CoA hydratase JO41_02445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase JO41_02450 ENOG4107Z3H Transcriptional regulator, TetR family JO41_02460 ENOG4105C3S Mate efflux family protein JO41_02470 ENOG4105DQ6 Transposase JO41_02475 ENOG41090WB Transposase is3 is911 JO41_02490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) JO41_02495 ENOG4105CD3 dihydroorotase JO41_02505 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) JO41_02515 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) JO41_02520 ENOG4105CXT aspartate transcarbamylase JO41_02530 ENOG4105VXR cytoplasmic protein JO41_02555 ENOG4105BZ1 (ABC) transporter JO41_02560 ENOG4105C9M aspartyl-trna synthetase JO41_02565 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) JO41_02620 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) JO41_02630 ENOG4105F1A Pyruvate formate-lyase JO41_02640 ENOG4105C6N Formate acetyltransferase JO41_02650 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) JO41_02655 ENOG4106447 Preprotein translocase subunit SecG JO41_02665 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO41_02670 ENOG4105CTQ phosphohexokinase JO41_02680 ENOG4105CUT histidyl-tRNA synthetase JO41_02685 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) JO41_02690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family JO41_02695 ENOG4105W0I repeat-containing protein JO41_02705 ENOG4105C8Q Methyl-accepting chemotaxis JO41_02740 ENOG4105DTJ flagellar hook-associated protein JO41_02745 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) JO41_02750 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) JO41_02755 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO41_02765 ENOG4105K8N protein family UPF0079, ATPase JO41_02770 ENOG4105C34 Pseudouridine synthase JO41_02795 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) JO41_02830 ENOG4108IJ0 Aspartate ammonia-lyase JO41_02835 ENOG4105KG3 cytidine deaminase JO41_02855 ENOG4108UHU Aldolase JO41_02895 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) JO41_02900 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) JO41_02925 ENOG4105C3J Cysteine desulfurase JO41_02945 ENOG4107TFB basic membrane JO41_02950 ENOG4108JQ9 ABC transporter JO41_02955 ENOG4105UIB (ABC) transporter JO41_03005 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) JO41_03010 ENOG4105CK7 Sodium proline symporter JO41_03020 ENOG4105FA0 parb-like partition protein JO41_03025 ENOG4107QJE Chromosome Partitioning Protein JO41_03030 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) JO41_03065 ENOG4105Z8J JO41_03080 ENOG4105DMT epimerase dehydratase JO41_03105 ENOG4107QQG Dehydrogenase JO41_03110 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase JO41_03135 ENOG4105J5G Transferase hexapeptide repeat containing protein JO41_03140 ENOG4105E4P ATPase (AAA JO41_03175 ENOG4105DFM M18 family aminopeptidase JO41_03180 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) JO41_03215 ENOG4105G3C Type iv pilus assembly JO41_03225 ENOG4105CPF Cell wall formation (By similarity) JO41_03240 ENOG4108RVA ribokinase JO41_03245 ENOG4108RVA ribokinase JO41_03250 ENOG4105DU0 nucleoside hydrolase JO41_03265 ENOG4108JQ9 ABC transporter JO41_03270 ENOG4105DIH basic membrane JO41_03280 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase JO41_03285 ENOG4105EHZ conserved protein UCP016719 JO41_03295 ENOG4105CJW magnesium transporter JO41_03305 ENOG4106SWD JO41_03310 ENOG4105C7N Xanthine uracil vitamin C permease JO41_03350 ENOG4105C8J )-transporter JO41_03355 ENOG4106VIZ JO41_03360 ENOG4107V28 uracil phosphoribosyltransferase JO41_03365 ENOG4105DK7 lysyl-tRNA synthetase JO41_03375 ENOG4105KZ7 phosphocarrier protein hpr JO41_03380 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) JO41_03400 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) JO41_03415 ENOG4105MJ2 Competence protein JO41_03420 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JO41_03425 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) JO41_03435 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) JO41_03445 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein JO41_03450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins JO41_03460 ENOG4105VG0 50S ribosomal protein l34 JO41_03485 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) JO41_03490 ENOG4105D17 glycoside hydrolase, family 3 domain protein JO41_03495 ENOG4105C3M thioredoxin reductase JO41_03500 ENOG4108IJ2 phosphate acetyltransferase JO41_03505 ENOG4106RHC JO41_03525 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) JO41_03530 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) JO41_03550 ENOG4105I03 Flagellin JO41_03555 ENOG4105I03 Flagellin JO41_03560 ENOG4107VE5 flagellar hook-associated protein JO41_03565 ENOG4106SAP JO41_03575 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) JO41_03580 ENOG4105CQ7 ATP-dependent helicase JO41_03590 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) JO41_03630 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) JO41_03635 ENOG4105CJR Integral membrane protein (MviN JO41_03655 ENOG4105DSE periplasmic solute binding protein JO41_03675 ENOG4108M1M outer membrane lipoprotein-sorting protein JO41_03680 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) JO41_03685 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO41_03700 ENOG4108TGR phosphatase JO41_03705 ENOG4105EI2 Pseudouridine synthase JO41_03760 ENOG4105VEM Conserved domain protein JO41_03765 ENOG4105C8Q Methyl-accepting chemotaxis JO41_03775 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) JO41_03780 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) JO41_03800 ENOG41067SE Tetr family transcriptional regulator JO41_03830 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) JO41_03835 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) JO41_03840 ENOG4105CHR reductase JO41_03845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase JO41_03850 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) JO41_03865 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) JO41_03870 ENOG41084MZ 50S ribosomal protein L35 JO41_03875 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) JO41_03880 ENOG4106BH8 JO41_03885 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) JO41_03890 ENOG41082MQ UPF0178 protein JO41_03895 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO41_03900 ENOG4105CIN aminoacyl-histidine dipeptidase JO41_03905 ENOG4105BZG amino acid carrier protein JO41_03910 ENOG4107QSA Oxaloacetate decarboxylase JO41_03915 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) JO41_03920 ENOG4106URY JO41_03935 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) JO41_03950 ENOG4108TVJ Nitroreductase JO41_03955 ENOG4105DA5 (ABC) transporter JO41_03975 ENOG4105D1H recombination factor protein RarA JO41_03985 ENOG4105XBK JO41_04040 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) JO41_04050 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family JO41_04065 ENOG4105FDK ABC transporter JO41_04070 ENOG4108HU6 Metal dependent phosphohydrolase JO41_04080 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein JO41_04090 ENOG4105C0F tryptophanase EC 4.1.99.1 JO41_04095 ENOG4105C8J )-transporter JO41_04105 ENOG4108SSC basic membrane JO41_04110 ENOG4105C2J ABC transporter JO41_04115 ENOG4108TWB ABC transporter (Permease JO41_04125 ENOG4105E7D Protein of unknown function (DUF3375) JO41_04155 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) JO41_04180 ENOG4107RUE extracellular solute-binding protein family 1 JO41_04185 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit JO41_04200 ENOG4105EI2 Pseudouridine synthase JO41_04205 ENOG41089XN JO41_04215 ENOG4105D3R alkyl hydroperoxide reductase JO41_04220 ENOG4107S4Y M20 DapE family protein YgeY JO41_04230 ENOG4105VDM plasmid maintenance system antidote protein, xre family JO41_04260 ENOG4107MD5 glycoside hydrolase, family JO41_04265 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) JO41_04295 ENOG4105CN1 protease JO41_04310 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) JO41_04345 ENOG4106DC9 JO41_04350 ENOG4108ZT0 50S ribosomal protein l17 JO41_04355 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) JO41_04360 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) JO41_04365 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits JO41_04370 ENOG41067V7 50S ribosomal protein L36 JO41_04375 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) JO41_04380 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) JO41_04390 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) JO41_04395 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) JO41_04400 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) JO41_04405 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) JO41_04410 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits JO41_04415 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) JO41_04420 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) JO41_04425 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal JO41_04430 ENOG41086S0 50s ribosomal protein l29 JO41_04435 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) JO41_04440 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) JO41_04445 ENOG41082G4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) JO41_04450 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) JO41_04455 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity JO41_04460 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) JO41_04465 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) JO41_04470 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) JO41_04475 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) JO41_04480 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) JO41_04500 ENOG4107TIA phenylalanyl-tRNA synthetase (beta subunit) JO41_04520 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) JO41_04525 ENOG4105CNU cell division protein FtsK JO41_04540 ENOG4105M7K Involved in the transcription termination process (By similarity) JO41_04545 ENOG4107Z25 Basic membrane protein JO41_04555 ENOG4105F8V Hydrolase, tatD family JO41_04565 ENOG4105K6T rare lipoprotein A JO41_04615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JO41_04655 ENOG4105EV2 VWA domain protein interacting with AAA ATPase JO41_04665 ENOG4105E4P ATPase (AAA JO41_04675 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) JO41_04685 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO41_04690 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component JO41_04705 ENOG4105C87 Aminotransferase class I and II JO41_04750 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) JO41_04755 ENOG4108Z29 Flavodoxin JO41_04765 ENOG4108ZGC gaf domain protein JO41_04775 ENOG4105CB5 ATP-dependent DNA helicase recG JO41_04780 ENOG410624X efflux transporter, rnd family, mfp subunit JO41_04785 ENOG4105C19 ABC transporter JO41_04790 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO41_04805 ENOG41090Q2 JO41_04830 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) JO41_04840 ENOG4105BZ1 (ABC) transporter JO41_04845 ENOG4105KRQ Addiction module toxin, Txe YoeB family JO41_04900 ENOG4105D29 Helix-turn-helix type 11 domain protein JO41_04910 ENOG4105BZ1 (ABC) transporter JO41_04915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) JO41_04920 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) JO41_04940 ENOG4105BZ1 (ABC) transporter JO41_04945 ENOG4105BZ1 (ABC) transporter JO41_04950 ENOG4108JJB ABC transporter JO41_04970 ENOG4105BZ1 (ABC) transporter JO41_04995 ENOG4105C59 p-type ATPase JO41_05010 ENOG4107SCN K03215 23S rRNA (uracil1939-C5)-methyltransferase EC 2.1.1.190 JO41_05030 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding JO41_05035 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) JO41_05040 ENOG4105C3G gtp-binding protein JO41_05060 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) JO41_05065 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) JO41_05075 ENOG4108QXE glycerophosphoryl diester phosphodiesterase JO41_05080 ENOG4107GZ4 SanA protein JO41_05110 ENOG4108ENG carbohydrate kinase, YjeF related protein JO41_05120 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) JO41_05125 ENOG4108PJD permease JO41_05145 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO41_05155 ENOG4105TQV JO41_05200 ENOG4105VFE sira family JO41_05210 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) JO41_05225 ENOG4107V8I Glycosyl transferases group 1 JO41_05230 ENOG4105C5H ABC transporter JO41_05250 ENOG4105C8Q Methyl-accepting chemotaxis JO41_05255 ENOG4105C72 UPF0176 protein JO41_05260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) JO41_05265 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO41_05285 ENOG4105BZU Histidine kinase JO41_05290 ENOG4105BZU Histidine kinase JO41_05295 ENOG4107S6Z Na H antiporter JO41_05310 ENOG4105S7Q restriction endonuclease JO41_05315 ENOG4107YVC modification (methylase) JO41_05400 ENOG4106JH4 JO41_05410 ENOG4105D2T synthase JO41_05415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) JO41_05440 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) JO41_05450 ENOG4108V1T peptidylprolyl cis-trans isomerase JO41_05455 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase JO41_05490 ENOG4108I5U Uridine phosphorylase JO41_05495 ENOG4105DR5 peptidase JO41_05500 ENOG4105DZ1 carboxypeptidase JO41_05505 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JO41_05515 ENOG41073FS JO41_05525 ENOG4105C5X domain protein JO41_05595 ENOG41084YP 30S ribosomal protein S21 JO41_05610 ENOG4106KG8 JO41_05620 ENOG4105D98 threonine synthase JO41_05650 ENOG4105DPN Oligoendopeptidase f JO41_05675 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family JO41_05695 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) JO41_05700 ENOG4105CTQ phosphohexokinase JO41_05710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO41_05715 ENOG4105F38 ABC transporter, permease JO41_05720 ENOG4105D38 putrescine abc transporter JO41_05725 ENOG4106W1H JO41_05735 ENOG4105C6K Malic enzyme JO41_05745 ENOG41090QR JO41_05750 ENOG4105E0A ABC, transporter JO41_05755 ENOG4105EHG Permease protein JO41_05795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) JO41_05800 ENOG4105EXW epimerase dehydratase JO41_05810 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) JO41_05820 ENOG4105CKU formyltetrahydrofolate synthetase JO41_05830 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO41_05835 ENOG4105DR5 peptidase JO41_05845 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) JO41_05865 ENOG4105C5T Phosphoribosyl pyrophosphate synthase JO41_05885 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 JO41_05890 ENOG4107S1W 4-alpha-glucanotransferase JO41_05895 ENOG4105CMR udp-glucose 4-epimerase JO41_05900 ENOG41077G2 JO41_05965 ENOG41067S9 phage shock protein C, PspC JO41_05975 ENOG4105VUN Transcriptional regulator JO41_05990 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) JO41_05995 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) JO41_06000 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) JO41_06010 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) JO41_06015 ENOG4105C8Q Methyl-accepting chemotaxis JO41_06020 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins JO41_06030 ENOG4105CFP Peptidase U32 JO41_06050 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein JO41_06065 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO41_06070 ENOG41083MR nifu domain-containing protein JO41_06090 ENOG4105DR5 peptidase JO41_06125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) JO41_06160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JO41_06185 ENOG4105CVR type I restriction-modification system JO41_06190 ENOG4105C8Q Methyl-accepting chemotaxis JO41_06195 ENOG4105DZW Dipeptidase JO41_06200 ENOG4105C8Q Methyl-accepting chemotaxis JO41_06210 ENOG4105C8Q Methyl-accepting chemotaxis JO41_06220 ENOG4105CGH 5'-nucleotidase JO41_06230 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) JO41_06235 ENOG4107I03 JO41_06245 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) JO41_06260 ENOG4105DWF phosphomethylpyrimidine kinase JO41_06270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) JO41_06285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family JO41_06290 ENOG41062D9 Histidine kinase JO41_06300 ENOG4105C0H protease JO41_06310 ENOG4108UMI ABC transporter, permease JO41_06320 ENOG4105D4B ABC, transporter JO41_06330 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane JO41_06345 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) JO41_06360 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component JO41_06365 ENOG4105DRS transport system, permease JO41_06370 ENOG4105C1J atp-dependent rna helicase JO41_06380 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) JO41_06390 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) JO41_06430 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) JO41_06435 ENOG4105C6K Malic enzyme JO41_06445 ENOG41082Y9 Single-strand binding protein JO41_06490 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP JO41_06500 ENOG4105C98 muts2 protein JO41_06515 ENOG4105EZ5 reductase JO41_06520 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family JO41_06530 ENOG4105DB7 PHP domain protein JO41_06540 ENOG4105IJJ transcriptional regulator, crp fnr family JO41_06545 ENOG4108JA2 transcriptioN-repair coupling factor JO41_06710 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) JO41_06715 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) JO41_06720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase JO41_06725 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein JO41_06730 ENOG4105RKW reductase (By JO41_06735 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) JO41_06740 ENOG4105D6A Electron transport complex JO41_06745 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit JO41_06750 ENOG4105DZB Electron transport complex JO41_06755 ENOG4105DGN Electron transport complex JO41_06760 ENOG4108R3D Electron transport complex JO41_06765 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) JO41_06770 ENOG4105FAV ABC, transporter JO41_06775 ENOG4105IW6 Carbamoyltransferase JO41_06780 ENOG4107S4Y M20 DapE family protein YgeY JO41_06815 ENOG4105HA9 of methanol dehydrogenase type JO41_06825 ENOG4108UJD 30S ribosomal protein S9 JO41_06830 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) JO41_06845 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving JO41_06910 ENOG4108YZG isomerase JO41_06925 ENOG4105KVH Transcriptional regulator JO41_06970 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JO41_06975 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) JO41_06980 ENOG4105D7A ATP-binding protein JO41_06990 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase JO41_06995 ENOG4105C98 muts2 protein JO41_07000 ENOG4105I03 Flagellin JO41_07005 ENOG4106N2C JO41_07015 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 JO41_07030 ENOG4105C59 p-type ATPase JO41_07055 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase JO41_07060 ENOG4105D2K citrate carrier protein JO41_07080 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) JO41_07085 ENOG4105DUA (citrate (pro-3S)-lyase ligase JO41_07115 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) JO41_07130 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO41_07150 ENOG4105DAP Nicotinate phosphoribosyltransferase JO41_07175 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for JO41_07180 ENOG4105C31 Tryptophanyl-tRNA synthetase JO41_07195 ENOG4105HFZ Membrane JO41_07220 ENOG4107YZD Protein of unknown function DUF115 JO41_07225 ENOG4105CJN penicillin-binding protein JO41_07505 ENOG4105M6F mutator MutT protein JO41_07530 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) JO41_07535 ENOG4106AHS JO41_07550 ENOG4105C0H protease JO41_07555 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) JO41_07575 ENOG4107QUY Guanine deaminase JO41_07580 ENOG4105CPN adenine deaminase JO41_07585 ENOG4105C7W Xanthine dehydrogenase JO41_07590 ENOG4108HR6 Dehydrogenase JO41_07605 ENOG41086D8 Transcriptional regulator JO41_07620 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) JO41_07635 ENOG4105CSA Coproporphyrinogen iii oxidase JO41_07640 ENOG4105C3F Signal peptidase i JO41_07645 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) JO41_07650 ENOG4106QD2 JO41_07655 ENOG4105DVT helicase JO41_07670 ENOG4106TEA JO41_07675 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO41_07685 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) JO41_07715 ENOG4107U1W v-type ATP synthase subunit I JO41_07720 ENOG4108WBK V-type ATP synthase subunit D JO41_07725 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit JO41_07730 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) JO41_07740 ENOG4108RY1 ATP synthase, subunit E JO41_07745 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) JO41_07755 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) JO41_07760 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase JO41_07765 ENOG4108V1U phospholipid-binding protein JO41_07770 ENOG4107UIE peptidase JO41_07860 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein JO41_07865 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) JO41_07870 ENOG4105ECY inositol monophosphatase JO41_07875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) JO41_07895 ENOG4105K56 Transcriptional regulator JO41_07915 ENOG4105HA9 of methanol dehydrogenase type JO41_07920 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) JO41_07925 ENOG4105C1J atp-dependent rna helicase JO41_07930 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) JO41_07935 ENOG4105DF5 DNA topoisomerase IV, subunit A JO41_07950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) JO41_07965 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ JO41_07970 ENOG4105CFG Acts as a chaperone (By similarity) JO41_07975 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO41_08000 ENOG4108I5C dEAD DEAH box helicase JO41_08020 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate JO41_08025 ENOG4105CEN a g-specific adenine glycosylase JO41_08030 ENOG4108Z4J Cytidine monophosphate kinase JO41_08040 ENOG4105DFU Cell wall formation (By similarity) JO41_08060 ENOG4105CSM endonuclease III JO41_08375 ENOG4105Z8H single-stranded DNA-binding protein JO41_08415 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation JO41_08420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JO41_08425 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) JO41_08430 ENOG41071ZZ JO41_08435 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) JO41_08455 ENOG4105E5G Alpha beta hydrolase fold JO41_08470 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) JO41_08475 ENOG4105C75 arginyL-tRNA synthetase JO41_08490 ENOG4105CEU Arginine dihydrolase JO41_08495 ENOG4105DBV ornithine carbamoyltransferase JO41_08500 ENOG4105C5B carbamate kinase JO41_08505 ENOG4105CSX c4-dicarboxylate anaerobic carrier JO41_08515 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) JO41_08520 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) JO41_08525 ENOG4105C5S asparaginyl-tRNA synthetase JO41_08540 ENOG4105KVH Transcriptional regulator JO41_08615 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) JO41_08630 ENOG4105K63 Thioredoxin JO41_08635 ENOG4105D48 metallophosphoesterase JO41_08640 ENOG4105C9B Cysteine desulfurase JO41_08650 ENOG4105DIW FeS assembly protein SUFB JO41_08700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) JO41_08715 ENOG4107S1Q Phosphatase JO41_08720 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) JO41_08745 ENOG4105C3F Signal peptidase i JO41_08755 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer JO41_08760 ENOG4105ZFX JO41_08770 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs JO41_08780 ENOG4107QKZ Ompa motb domain protein JO41_08785 ENOG4108ETT Dehydrogenase JO41_08795 ENOG4109031 JO41_08815 ENOG4105C1G acyl-Coa dehydrogenase JO41_08820 ENOG4105C26 Dehydrogenase JO41_08845 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) JO41_08875 ENOG4105CGA flagellar basal-body rod protein FlgG JO41_08880 ENOG4105CGA flagellar basal-body rod protein FlgG JO41_08885 ENOG410680E Flagellar protein JO41_08900 ENOG4105E0A ABC, transporter JO41_08905 ENOG4105EHG Permease protein JO41_08935 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) JO41_08940 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) JO41_08960 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) JO41_08965 ENOG4105KME endoribonuclease L-psp JO41_08980 ENOG4108YZY peptidylprolyl cis-trans isomerase JO41_08985 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) JO41_08995 ENOG4105K46 50S ribosomal protein l27 JO41_09000 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control JO41_09005 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) JO41_09030 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) JO41_09035 ENOG4105CHV Transcription elongation factor NusA JO41_09040 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) JO41_09045 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) JO41_09050 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) JO41_09055 ENOG4105DTN riboflavin biosynthesis protein ribF JO41_09060 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) JO41_09065 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) JO41_09070 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) JO41_09085 ENOG4105C8Q Methyl-accepting chemotaxis JO41_09105 ENOG4105C8Q Methyl-accepting chemotaxis JO41_09115 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) JO41_09120 ENOG4108I0N Transporter, RarD family, DMT superfamily protein JO41_09125 ENOG4105K95 (LipO)protein JO41_09130 ENOG4105C2J ABC transporter JO41_09175 ENOG4105D5T phosphonate abc transporter JO41_09190 ENOG4105D3A purine nucleoside phosphorylase DeoD-type JO41_09200 ENOG4106FRC JO41_09205 ENOG4105JTB JO41_09225 ENOG4106XCQ Inherit from COG: Pfam:DUF82 JO41_09245 ENOG410828M hemerythrin-like, metal-binding protein JO41_09250 ENOG4108IUM Glycogen debranching enzyme JO41_09255 ENOG4107FKK extracellular solute-binding protein family 1 JO41_09275 ENOG4105EG2 ABC transporter, permease JO41_09290 ENOG4105C4R Atp-dependent dna helicase JO41_09305 ENOG4107QW4 alcohol dehydrogenase JO41_09320 ENOG4108YZG isomerase JO41_09335 ENOG4105BZ1 (ABC) transporter JO41_09435 ENOG410822I Flagellar hook capping protein JO41_09440 ENOG4105BZE flagellar hook protein, FlgE JO41_09450 ENOG4107R0U MotA TolQ exbB proton channel JO41_09455 ENOG4107XSU flagellar motor protein motb JO41_09460 ENOG41064SM flagellar basal body-associated protein flil JO41_09465 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO41_09470 ENOG4105DD5 Flagellar motor switch protein JO41_09480 ENOG4105CN7 Flagellar biosynthetic protein FliP JO41_09485 ENOG4105VS8 Flagellar biosynthetic protein fliq JO41_09495 ENOG4105D00 flagellar biosynthetic protein flhB JO41_09500 ENOG4105D7B Flagellar biosynthesis protein flha JO41_09505 ENOG4105FZW flagellar biosynthesis regulator FlhF JO41_09510 ENOG4107R21 site-determining protein JO41_09520 ENOG4105UQX Mate efflux family protein JO41_09535 ENOG4105DFM M18 family aminopeptidase JO41_09545 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family JO41_09550 ENOG4105C0B DNA polymerase III (alpha subunit) JO41_09560 ENOG4107R2W ABC transporter, permease JO41_09565 ENOG4105C2J ABC transporter JO41_09570 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator JO41_09575 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) JO41_09595 ENOG41090QV Protein of unknown function DUF115 JO41_09605 ENOG410698I JO41_09620 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) JO41_09625 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) JO41_09630 ENOG4105C79 DNA protecting protein DprA JO41_09645 ENOG4107RWR Sodium hydrogen exchanger JO41_09655 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) JO41_09665 ENOG4108SDV Periplasmic Protein JO41_09680 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO41_09685 ENOG4105C19 ABC transporter JO41_09720 ENOG4108I0C methyltransferase JO41_09765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) JO41_09770 ENOG4105C8Q Methyl-accepting chemotaxis JO41_09780 ENOG4105C9U ATP-dependent DNA helicase RecQ JO41_09790 ENOG4105CGH 5'-nucleotidase JO41_09800 ENOG4108IQE Amp-dependent synthetase and ligase JO41_09805 ENOG4105K59 histidine triad (HIT) protein JO41_09810 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) JO41_09815 ENOG4105K4W Could be involved in septation (By similarity) JO41_09825 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) JO41_09830 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) JO41_09835 ENOG41069X2 JO41_09845 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) JO41_09850 ENOG41061XC JO41_09855 ENOG4105C8Q Methyl-accepting chemotaxis JO41_09860 ENOG4105C5I Dehydrogenase JO41_09865 ENOG4105D6U Sodium Glutamate Symporter JO41_09880 ENOG4105D9Q decarboxylase (Beta subunit) JO41_09885 ENOG4105DMN coenzyme A transferase JO41_09890 ENOG4107UHT Glutaconate CoA-transferase JO41_09895 ENOG4107QX3 carboxylase JO41_09900 ENOG4105D6U Sodium Glutamate Symporter JO41_09905 ENOG4105CIZ coA-substrate-specific enzyme activase JO41_09910 ENOG4105CMH dehydratase JO41_09915 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase JO41_09925 ENOG41090R7 Ferric uptake JO41_09930 ENOG4106UV5 membrane protein A JO41_09940 ENOG4105M6F mutator MutT protein JO41_09960 ENOG4105CTJ Metal Dependent Phosphohydrolase JO41_09965 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) JO41_09970 ENOG4105C37 (CBS) domain JO41_09995 ENOG4105CNW domain protein JO41_10000 ENOG4108Y51 tRNA-binding protein JO41_10010 ENOG4105CEY Amp-dependent synthetase and ligase JO41_10020 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) JO41_10065 ENOG4105C22 threonyL-tRNA synthetase JO41_10075 ENOG4105BZA Phosphoglycerate kinase JO41_10105 ENOG41090KZ JO41_10110 ENOG4105BZU Histidine kinase JO41_10115 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) JO41_10130 ENOG4105IJJ transcriptional regulator, crp fnr family JO41_10135 ENOG4107QWW Cell wall formation (By similarity) JO41_10145 ENOG4105C8N cysteinyl-tRNA synthetase JO41_10150 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO41_10165 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) JO41_10170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) JO41_10175 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) JO41_10190 ENOG4105T73 JO41_10195 ENOG4105DJV ribulose-phosphate 3-epimerase JO41_10215 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) JO41_10220 ENOG4106B9X JO41_10225 ENOG4107QMG Nad synthetase JO41_10250 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) JO41_10255 ENOG4107QP8 phosphohexose isomerase JO41_10265 ENOG4107RCH Diaminopropionate ammonia-lyase JO41_10280 ENOG4105CY0 Metallo-Beta-Lactamase JO41_10285 ENOG4105C2N RNA methyltransferase TrmH family group 3 JO41_10290 ENOG4105EIB trna rrna methyltransferase JO41_10300 ENOG4108SXE JO41_10305 ENOG41073RW Cytoplasmic filament protein A JO41_10310 ENOG4105YQK von Willebrand factor type A domain JO41_10315 ENOG4106BN6 JO41_10320 ENOG4105CHU acetyl-coa acetyltransferase JO41_10335 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) JO41_10340 ENOG4108JJB ABC transporter JO41_10355 ENOG4105ID8 Transcriptional regulator, ARAC family JO41_10370 ENOG4108JJB ABC transporter JO41_10415 ENOG4108IG5 Transcriptional regulator JO41_10430 ENOG4108JJB ABC transporter JO41_10475 ENOG4105CUZ uba thif-type nad fad binding protein JO41_10480 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) JO41_10485 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) JO41_10490 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A JO41_10510 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) JO41_10515 ENOG4107QMP dna polymerase iii subunits gamma and tau JO41_10530 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) JO41_10535 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) JO41_10575 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase JO41_10580 ENOG4105D17 glycoside hydrolase, family 3 domain protein JO41_10585 ENOG4105EHZ conserved protein UCP016719 JO41_10590 ENOG4106XHX JO41_10595 ENOG4108ZG0 Ompa motb domain protein JO41_10600 ENOG4105E9H Lytic Murein transglycosylase JO41_10640 ENOG4106S0F JO41_10650 ENOG4105K78 MarR family Transcriptional regulator JO41_10675 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) JO41_10680 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) JO41_10700 ENOG4105DFF Rod shape-determining protein mreb JO41_10715 ENOG4105CJN penicillin-binding protein JO41_10720 ENOG4105CNI cell division protein FtsW JO41_10730 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) JO41_10735 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) JO41_10740 ENOG4105CZV ABC transporter JO41_10765 ENOG4105BZ1 (ABC) transporter JO41_10790 ENOG41067SE Tetr family transcriptional regulator JO41_10820 ENOG4107QJT sodium dicarboxylate symporter JO41_10840 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) JO41_10850 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) JO41_10870 ENOG4105C5I Dehydrogenase JO41_10875 ENOG4107RIZ hflk protein JO41_10880 ENOG4105EPW hflc protein JO41_10890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein JO41_10905 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) JO41_10930 ENOG4105CVA phosphate JO41_10960 ENOG4108T5G Adenylate JO41_10965 ENOG4105BZ1 (ABC) transporter JO41_10970 ENOG4108JJ9 ABC, transporter JO41_10980 ENOG41062VP JO41_10990 ENOG4105VVB JO41_11000 ENOG4105C2M dna polymerase I JO41_11005 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) JO41_11030 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) JO41_11040 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) JO41_11045 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) JO41_11050 ENOG4107T0D ABC, transporter JO41_11060 ENOG4105CEY Amp-dependent synthetase and ligase JO41_11065 ENOG4108QBX (LipO)protein JO41_11070 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase JO41_11100 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) JO41_11140 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) JO41_11145 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) JO41_11150 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase JO41_11155 ENOG4105YFD chemotaxis, protein JO41_11165 ENOG41085BT Protein of unknown function (DUF1312) JO41_11180 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) JO41_11190 ENOG4108Z03 MAF-like protein JO41_11195 ENOG4105CE9 30S ribosomal protein S2 JO41_11200 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) JO41_11205 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) JO41_11210 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) JO41_11215 ENOG4105KNE Phosphatidate cytidylyltransferase JO41_11220 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) JO41_11225 ENOG4105DZP Membrane-associated zinc metalloprotease JO41_11230 ENOG41062Z1 JO41_11235 ENOG4105X1A JO41_11240 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) JO41_11250 ENOG4108M1M outer membrane lipoprotein-sorting protein JO41_11275 ENOG4105CV1 Transketolase (EC 2.2.1.1) JO41_11280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 JO41_11295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) JO41_11300 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) JO41_11305 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) JO41_11310 ENOG41082BE ankyrin repeat-containing protein JO41_11315 ENOG4105CKD glutathione-regulated potassium-efflux system protein JO41_11320 ENOG4106ARS JO41_11325 ENOG4107RFW hydrolase family 57 JO41_11330 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) JO41_11335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) JO41_11345 ENOG4105CJ1 ABC, transporter JO41_11350 ENOG4105DZW Dipeptidase JO41_11375 ENOG4105EJQ L-serine dehydratase JO41_11385 ENOG4105CP7 Triose-phosphate isomerase JO41_11400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) JO41_11405 ENOG4108UMI ABC transporter, permease JO41_11415 ENOG4105CH2 amidohydrolase JO41_11450 ENOG4105HCZ JO41_11465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO41_11470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) JO41_11480 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) JO41_11485 ENOG4107QYI peptidase JO41_11490 ENOG4105DNX Dna topoisomerase iv (Subunit b) JO41_11495 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) JO41_11500 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein JO41_11505 ENOG4105DN3 alpha-2-macroglobulin domain protein JO41_11535 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) JO41_11540 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) JO41_11550 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO41_11570 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) JO41_11625 ENOG4105BZ1 (ABC) transporter JO41_11645 ENOG4108JJB ABC transporter JO41_11650 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) JO41_11655 ENOG4105CEM UPF0597 protein JO41_11675 ENOG4105EHG Permease protein JO41_11690 ENOG4105BZ1 (ABC) transporter JO41_11700 ENOG4108V0P LemA family JO41_11705 ENOG4108IG5 Transcriptional regulator JO41_11715 ENOG4105BZ1 (ABC) transporter JO41_11720 ENOG4105BZ1 (ABC) transporter JO41_11725 ENOG4105DRR Transcriptional regulator, GntR family JO41_11730 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) JO41_11735 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein JO41_11740 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) JO41_11745 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) JO41_11755 ENOG4107QRG dna polymerase iii JO41_11770 ENOG4105CDU Replicative dna helicase JO41_11775 ENOG4105K9Q Binds to the 23S rRNA (By similarity) JO41_11780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) JO41_11785 ENOG4105Z8H single-stranded DNA-binding protein JO41_11790 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) JO41_11795 ENOG4105CKI cobalamin synthesis protein JO41_11800 ENOG4105UQX Mate efflux family protein JO41_11815 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) JO41_11820 ENOG4105C3J Cysteine desulfurase JO41_11825 ENOG4105D49 3-dehydroquinate synthase JO41_11835 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) JO41_11845 ENOG41082AN stage II sporulation protein JO41_11880 ENOG4105C5W Aldolase JO41_11885 ENOG4105KST dependent repressor JO41_11890 ENOG4105DSE periplasmic solute binding protein JO41_11895 ENOG4105DIK (ABC) transporter JO41_11905 ENOG4105CC5 ABC transporter JO41_11920 ENOG4105EWC Purine nucleoside phosphorylase JO41_11935 ENOG41066A3 ATP guanido phosphotransferase JO41_11945 ENOG4108JUB Transcriptional regulator JO41_11955 ENOG4105BZU Histidine kinase JO41_11960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family JO41_11965 ENOG4105MB2 JO41_12000 ENOG4105CYC Transferase JO41_12005 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) JO41_12010 ENOG41083MR nifu domain-containing protein JO41_12040 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase JO41_12055 ENOG4105CGK Exodeoxyribonuclease III JO41_12065 ENOG4105WD1 Membrane JO41_12070 ENOG4108IUZ ABC transporter JO41_12100 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) JO41_12115 ENOG4105E0A ABC, transporter JO41_12140 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) JO41_12150 ENOG4108JDX DNA polymerase iii, epsilon subunit JO41_12165 ENOG4108JQC penicillin-binding protein 1A JO41_12185 ENOG4108QUE repeat-containing protein JO41_12190 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase JO41_12195 ENOG4105C8J )-transporter JO41_12200 ENOG4105EWK phytoene JO41_12205 ENOG4105FE1 phytoene synthase JO41_12215 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) JO41_12225 ENOG4106GEY JO41_12230 ENOG41062BZ domain protein JO41_12240 ENOG4105C0P Mg chelatase subunit ChlI JO41_12245 ENOG4108JQB penicillin-binding protein 1C JO41_12250 ENOG4105E4P ATPase (AAA JO41_12490 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) JO41_12495 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) JO41_12510 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) JO41_12515 ENOG4105D60 lipoprotein releasing system transmembrane protein JO41_12525 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) JO41_12535 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) JO41_12550 ENOG4108JJB ABC transporter JO41_12555 ENOG4105VKD bioY protein JO41_12560 ENOG4105ZF0 Lipoprotein JO41_12565 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase JO41_12570 ENOG4108VXD carboxy-peptidase JO41_12600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component JO41_12605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component JO41_12610 ENOG4108JQ7 (ABC) transporter JO41_12620 ENOG4108KP7 hydrolase JO41_12625 ENOG4105CHM Aminotransferase JO41_12630 ENOG4108ZB6 transcriptional regulator AsnC family JO41_12635 ENOG4106R77 JO41_12640 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) JO41_12645 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) JO41_12650 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) JO41_12660 ENOG4105C8B TIGR00159 family JO41_12665 ENOG4105EEI dihydropteroate synthase