locus-tag	class	description
E4N65_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N65_00015	COG1373	ATPase (AAA superfamily
E4N65_00025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4N65_00035	COG0714	Associated with various cellular activities
E4N65_00065	COG0714	Associated with various cellular activities
E4N65_00355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N65_00365	COG0084	hydrolase, TatD family'
E4N65_00370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N65_00375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N65_00395	COG1674	ftsk spoiiie
E4N65_00400	COG1968	undecaprenyl-diphosphatase activity
E4N65_00405	COG0741	lytic transglycosylase activity
E4N65_00440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N65_00445	COG0051	transcription antitermination factor activity, RNA binding
E4N65_00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N65_00455	COG0088	Forms part of the polypeptide exit tunnel
E4N65_00460	COG0089	rRNA binding
E4N65_00465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N65_00475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N65_00480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N65_00490	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N65_00495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N65_00500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N65_00505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N65_00510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N65_00520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N65_00525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N65_00535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N65_00545	COG0200	Binds to the 23S rRNA
E4N65_00555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N65_00565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N65_00570	COG0202	RNA polymerase activity
E4N65_00575	COG0203	ribosomal protein L17
E4N65_00605	COG0793	Belongs to the peptidase S41A family
E4N65_00635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N65_00645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4N65_00680	COG2161	toxin-antitoxin pair type II binding
E4N65_00695	COG2361	Protein of unknown function DUF86
E4N65_00760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N65_00765	COG0450	alkyl hydroperoxide reductase
E4N65_00775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N65_00795	COG0542	response to heat
E4N65_00800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4N65_00810	COG4536	flavin adenine dinucleotide binding
E4N65_00815	COG1253	flavin adenine dinucleotide binding
E4N65_00820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N65_00830	COG3177	Filamentation induced by cAMP protein fic
E4N65_00845	COG4942	peptidase
E4N65_00855	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N65_00860	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N65_00865	COG1129	ABC transporter
E4N65_00870	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N65_00880	COG0733	neurotransmitter:sodium symporter activity
E4N65_00895	COG0543	2 iron, 2 sulfur cluster binding
E4N65_00900	COG1639	'signal transduction protein
E4N65_00905	COG1121	(ABC) transporter
E4N65_00920	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N65_00920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N65_00930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N65_00945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N65_00950	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4N65_00960	COG4656	Part of a membrane complex involved in electron transport
E4N65_00995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N65_01015	COG1131	(ABC) transporter
E4N65_01020	COG0778	Nitroreductase
E4N65_01035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N65_01050	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N65_01055	COG5016	pyruvate
E4N65_01055	COG0511	ligase activity, forming carbon-carbon bonds
E4N65_01060	COG1115	amino acid carrier protein
E4N65_01065	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N65_01070	COG3437	response regulator, receiver
E4N65_01075	COG1671	Belongs to the UPF0178 family
E4N65_01080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N65_01095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N65_01110	COG0513	Belongs to the DEAD box helicase family
E4N65_01115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N65_01120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N65_01125	COG1028	Short-chain dehydrogenase reductase Sdr
E4N65_01130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N65_01140	COG1647	Serine aminopeptidase, S33
E4N65_01165	COG1309	transcriptional regulator
E4N65_01185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N65_01190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N65_01190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N65_01200	COG0840	transmembrane signaling receptor activity
E4N65_01205	COG4443	Transcriptional Coactivator p15 (PC4)
E4N65_01420	COG0564	pseudouridine synthase activity
E4N65_01450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N65_01460	COG0419	ATPase involved in DNA repair
E4N65_01470	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N65_01485	COG0728	peptidoglycan biosynthetic process
E4N65_01520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N65_01535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N65_01550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N65_01550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N65_01555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N65_01560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N65_01580	COG1151	hydroxylamine reductase activity
E4N65_01600	COG0280	phosphate acetyltransferase
E4N65_01605	COG0492	ferredoxin-NADP+ reductase activity
E4N65_01610	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N65_01615	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N65_01650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N65_01655	COG0706	membrane insertase activity
E4N65_01660	COG1847	R3H domain protein
E4N65_01670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N65_01675	COG1862	Preprotein translocase
E4N65_01680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N65_01685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N65_01690	COG1040	competence protein
E4N65_01700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N65_01710	COG0058	SHG alpha-glucan phosphorylase activity
E4N65_01725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N65_01730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N65_01740	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N65_01745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N65_01750	COG0457	Tetratricopeptide repeat
E4N65_01755	COG0733	neurotransmitter:sodium symporter activity
E4N65_01795	COG2252	PERMEase
E4N65_01805	COG0170	dolichyl monophosphate biosynthetic process
E4N65_01810	COG2239	Acts as a magnesium transporter
E4N65_01820	COG3876	Protein conserved in bacteria
E4N65_01825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N65_01835	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N65_01840	COG3845	ABC transporter
E4N65_01850	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N65_01860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N65_01865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N65_01875	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N65_01920	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N65_01925	COG1362	aminopeptidase activity
E4N65_01960	COG1373	ATPase (AAA superfamily
E4N65_02005	COG1216	Glycosyl transferase, family 2
E4N65_02005	COG1442	glycosyl transferase family 8
E4N65_02015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N65_02040	COG1393	Belongs to the ArsC family
E4N65_02060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N65_02065	COG1192	Involved in chromosome partitioning
E4N65_02070	COG1475	DNA binding
E4N65_02080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4N65_02085	COG1418	mRNA catabolic process
E4N65_02130	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N65_02135	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N65_02140	COG3845	ABC transporter
E4N65_02145	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N65_02170	COG0709	Synthesizes selenophosphate from selenide and ATP
E4N65_02175	COG0556	nucleotide-excision repair
E4N65_02190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4N65_02220	COG0739	heme binding
E4N65_02230	COG0295	cytidine deaminase activity
E4N65_02235	COG1027	Aspartate ammonia-lyase
E4N65_02270	COG0297	glycogen (starch) synthase activity
E4N65_02285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N65_02295	COG0564	pseudouridine synthase activity
E4N65_02300	COG0802	atpase or kinase
E4N65_02305	COG1214	PFAM Peptidase M22, glycoprotease
E4N65_02310	COG3437	response regulator, receiver
E4N65_02310	COG2770	Histidine kinase
E4N65_02325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N65_02355	COG0840	transmembrane signaling receptor activity
E4N65_02365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N65_02380	COG0124	histidyl-tRNA synthetase
E4N65_02385	COG0205	6-phosphofructokinase activity
E4N65_02390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N65_02395	COG5001	Diguanylate cyclase
E4N65_02395	COG2203	Gaf domain
E4N65_02395	COG4251	negative regulation of phosphorylation
E4N65_02395	COG3706	GGDEF domain
E4N65_02400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N65_02405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N65_02410	COG1882	Formate acetyltransferase
E4N65_02415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4N65_02470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N65_02475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N65_02480	COG1132	(ABC) transporter
E4N65_02495	COG0500	methyltransferase
E4N65_02520	COG0668	transmembrane transport
E4N65_02525	COG0540	Belongs to the ATCase OTCase family
E4N65_02530	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N65_02535	COG0543	2 iron, 2 sulfur cluster binding
E4N65_02540	COG0167	dihydroorotate dehydrogenase activity
E4N65_02545	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N65_02550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N65_02555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N65_02580	COG2801	Transposase and inactivated derivatives
E4N65_02590	COG0534	Mate efflux family protein
E4N65_02595	COG3848	Pyruvate phosphate dikinase
E4N65_02595	COG0574	Belongs to the PEP-utilizing enzyme family
E4N65_02600	COG1309	transcriptional regulator
E4N65_02605	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4N65_02610	COG1024	Enoyl-CoA hydratase
E4N65_02615	COG0427	acetyl-CoA hydrolase
E4N65_02625	COG0762	integral membrane protein
E4N65_02640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N65_02645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N65_02650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N65_02665	COG1774	PSP1 C-terminal conserved region
E4N65_02680	COG0739	heme binding
E4N65_02690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N65_02695	COG2911	Protein conserved in bacteria
E4N65_02700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N65_02710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N65_02725	COG0739	heme binding
E4N65_02750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N65_02760	COG0826	peptidase U32
E4N65_02775	COG0601	transmembrane transport
E4N65_02780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N65_02785	COG0444	Belongs to the ABC transporter superfamily
E4N65_02790	COG4608	Belongs to the ABC transporter superfamily
E4N65_02795	COG0616	signal peptide processing
E4N65_02835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N65_02840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4N65_02855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N65_02860	COG1438	arginine binding
E4N65_02875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N65_02885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N65_02890	COG0250	Participates in transcription elongation, termination and antitermination
E4N65_02895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N65_02900	COG0081	regulation of translation
E4N65_02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N65_02910	COG0222	ribosome binding
E4N65_02915	COG0085	RNA polymerase activity
E4N65_02930	COG0049	tRNA binding
E4N65_02945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N65_02955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N65_02965	COG0217	transcriptional regulatory protein
E4N65_02990	COG2502	aspartate--ammonia ligase
E4N65_03000	COG0301	tRNA thio-modification
E4N65_03020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N65_03025	COG0322	excinuclease ABC activity
E4N65_03055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N65_03080	COG3588	fructose-bisphosphate aldolase
E4N65_03090	COG1477	protein flavinylation
E4N65_03105	COG1464	Belongs to the NlpA lipoprotein family
E4N65_03115	COG0084	hydrolase, TatD family'
E4N65_03120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N65_03120	COG3116	cell division
E4N65_03150	COG0488	(ABC) transporter
E4N65_03155	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4N65_03165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4N65_03170	COG0363	glucosamine-6-phosphate deaminase activity
E4N65_03175	COG0628	permease
E4N65_03180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N65_03185	COG0328	RNA-DNA hybrid ribonuclease activity
E4N65_03190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N65_03200	COG1175	transmembrane transport
E4N65_03205	COG0395	ABC-type sugar transport system, permease component
E4N65_03220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N65_03225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N65_03240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4N65_03240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4N65_03250	COG0840	transmembrane signaling receptor activity
E4N65_03260	COG1921	L-seryl-tRNASec selenium transferase activity
E4N65_03290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N65_03295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N65_03300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N65_03305	COG0571	ribonuclease III activity
E4N65_03310	COG0840	transmembrane signaling receptor activity
E4N65_03315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N65_03340	COG1157	protein secretion by the type III secretion system
E4N65_03345	COG1317	bacterial-type flagellum organization
E4N65_03355	COG1766	The M ring may be actively involved in energy transduction
E4N65_03370	COG1815	bacterial-type flagellum-dependent cell motility
E4N65_03375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N65_03380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N65_03385	COG3579	cysteine-type endopeptidase activity
E4N65_03415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N65_03450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N65_03455	COG0187	DNA topoisomerase II activity
E4N65_03475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N65_03490	COG2233	PERMEase
E4N65_03500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N65_03510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4N65_03515	COG0772	Belongs to the SEDS family
E4N65_03520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N65_03530	COG0275	rRNA processing
E4N65_03535	COG2001	Belongs to the MraZ family
E4N65_03550	COG0564	pseudouridine synthase activity
E4N65_03565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N65_03570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N65_03575	COG0302	gtp cyclohydrolase
E4N65_03575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4N65_03600	COG3549	Plasmid maintenance system killer
E4N65_03620	COG1070	Carbohydrate kinase
E4N65_03630	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N65_03635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4N65_03640	COG2186	Transcriptional regulator
E4N65_03655	COG0405	Gamma-glutamyltransferase
E4N65_03665	COG2604	Protein of unknown function DUF115
E4N65_03685	COG3142	Participates in the control of copper homeostasis
E4N65_03695	COG3620	sequence-specific DNA binding
E4N65_03750	COG1067	ATP-dependent peptidase activity
E4N65_03755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N65_03770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4N65_03775	COG0569	domain protein
E4N65_03785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4N65_03810	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E4N65_03815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N65_03820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N65_03835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N65_03840	COG2226	methyltransferase
E4N65_03855	COG0395	ABC-type sugar transport system, permease component
E4N65_03860	COG4209	transmembrane transport
E4N65_03885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4N65_03910	COG2373	Large extracellular alpha-helical protein
E4N65_03925	COG0785	Cytochrome C biogenesis protein
E4N65_03930	COG0583	DNA-binding transcription factor activity
E4N65_03945	COG2885	chlorophyll binding
E4N65_03950	COG2388	GCN5-related N-acetyl-transferase
E4N65_03970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N65_03975	COG0617	tRNA 3'-terminal CCA addition
E4N65_03985	COG3118	belongs to the thioredoxin family
E4N65_03995	COG2198	Histidine kinase
E4N65_03995	COG0643	Histidine kinase
E4N65_04000	COG0835	chemotaxis
E4N65_04010	COG2201	protein-glutamate methylesterase activity
E4N65_04025	COG0731	radical SAM domain protein
E4N65_04035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N65_04045	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N65_04065	COG0268	Binds directly to 16S ribosomal RNA
E4N65_04070	COG0776	regulation of translation
E4N65_04075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N65_04090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N65_04095	COG0254	rRNA binding
E4N65_04100	COG1272	protein, Hemolysin III
E4N65_04110	COG0523	cobalamin synthesis protein
E4N65_04125	COG0297	glycogen (starch) synthase activity
E4N65_04130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N65_04135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N65_04150	COG1598	PFAM Uncharacterised protein family UPF0150
E4N65_04155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N65_04185	COG1653	transport
E4N65_04190	COG0534	Mate efflux family protein
E4N65_04195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N65_04205	COG1309	transcriptional regulator
E4N65_04210	COG1620	l-lactate permease
E4N65_04215	COG4166	transmembrane transport
E4N65_04225	COG0395	ABC-type sugar transport system, permease component
E4N65_04230	COG1175	transmembrane transport
E4N65_04235	COG1653	transport
E4N65_04260	COG2971	BadF BadG BcrA BcrD
E4N65_04270	COG1573	uracil-dna glycosylase
E4N65_04275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N65_04280	COG1482	cell wall glycoprotein biosynthetic process
E4N65_04295	COG1413	lyase activity
E4N65_04300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N65_04305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4N65_04305	COG0116	Belongs to the methyltransferase superfamily
E4N65_04320	COG0343	queuine tRNA-ribosyltransferase activity
E4N65_04330	COG0840	transmembrane signaling receptor activity
E4N65_04335	COG2358	TRAP transporter, solute receptor (TAXI family
E4N65_04345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N65_04360	COG1773	rubredoxin
E4N65_04370	COG0495	leucyl-tRNA aminoacylation
E4N65_04430	COG0335	large ribosomal subunit rRNA binding
E4N65_04435	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N65_04440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N65_04445	COG1837	Belongs to the UPF0109 family
E4N65_04450	COG0228	four-way junction DNA binding
E4N65_04470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N65_04480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N65_04500	COG2211	Major facilitator Superfamily
E4N65_04510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N65_04515	COG0154	amidase activity
E4N65_04520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N65_04530	COG4254	PFAM FecR protein
E4N65_04540	COG1234	tRNA 3'-trailer cleavage
E4N65_04565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N65_04575	COG1747	RNA polymerase binding
E4N65_04575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N65_04585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N65_04590	COG3956	TIGRFAM MazG family protein
E4N65_04600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4N65_04605	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N65_04615	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N65_04625	COG0101	tRNA pseudouridine synthase activity
E4N65_04635	COG1522	sequence-specific DNA binding
E4N65_04640	COG0436	Aminotransferase
E4N65_04645	COG0561	phosphatase activity
E4N65_04655	COG4608	Belongs to the ABC transporter superfamily
E4N65_04660	COG0601	transmembrane transport
E4N65_04665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N65_04695	COG1876	peptidase activity
E4N65_04700	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N65_04710	COG1268	BioY protein
E4N65_04715	COG1122	ATPase activity
E4N65_04730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N65_04740	COG0552	protein localization to endoplasmic reticulum
E4N65_04750	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N65_04755	COG1136	(ABC) transporter
E4N65_04765	COG0142	geranyltranstransferase activity
E4N65_04770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N65_04775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N65_04995	COG1373	ATPase (AAA superfamily
E4N65_05000	COG4953	penicillin-binding protein 1C
E4N65_05015	COG0724	RNA recognition motif
E4N65_05020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N65_05030	COG1196	nuclear chromosome segregation
E4N65_05035	COG0170	dolichyl monophosphate biosynthetic process
E4N65_05040	COG1562	ergosterol biosynthetic process
E4N65_05045	COG1233	COG1233 Phytoene dehydrogenase and related
E4N65_05050	COG0733	neurotransmitter:sodium symporter activity
E4N65_05055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N65_05060	COG0457	Tetratricopeptide repeat
E4N65_05085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N65_05090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N65_05120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N65_05125	COG1120	ATPase activity
E4N65_05140	COG0402	S-adenosylhomocysteine deaminase activity
E4N65_05145	COG0493	'glutamate synthase
E4N65_05145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N65_05165	COG1137	ATPase activity
E4N65_05170	COG2832	Protein of unknown function (DUF454)
E4N65_05180	COG0708	Exodeoxyribonuclease III
E4N65_05195	COG1454	alcohol dehydrogenase
E4N65_05220	COG0823	Involved in the tonB-independent uptake of proteins
E4N65_05225	COG2204	response regulator
E4N65_05230	COG3852	Histidine kinase
E4N65_05240	COG3829	transcription factor binding
E4N65_05240	COG3290	protein histidine kinase activity
E4N65_05250	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N65_05260	COG1683	Conserved Protein
E4N65_05265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N65_05270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N65_05275	COG1121	(ABC) transporter
E4N65_05280	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N65_05285	COG1321	iron dependent repressor
E4N65_05290	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4N65_05325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N65_05335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N65_05340	COG1104	cysteine desulfurase activity
E4N65_05345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N65_05360	COG0534	Mate efflux family protein
E4N65_05365	COG0523	cobalamin synthesis protein
E4N65_05370	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N65_05375	COG0629	single-stranded DNA binding
E4N65_05380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N65_05385	COG0359	binds to the 23S rRNA
E4N65_05390	COG0305	Participates in initiation and elongation during chromosome replication
E4N65_05405	COG0470	DNA polymerase III
E4N65_05415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N65_05420	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N65_05425	COG1739	Uncharacterized protein family UPF0029
E4N65_05430	COG0632	four-way junction helicase activity
E4N65_05435	COG1802	Transcriptional regulator
E4N65_05440	COG1132	(ABC) transporter
E4N65_05445	COG1132	(ABC) transporter
E4N65_05455	COG1704	LemA family
E4N65_05470	COG3681	Belongs to the UPF0597 family
E4N65_05475	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N65_05480	COG1129	ABC transporter
E4N65_05500	COG1132	(ABC) transporter
E4N65_05515	COG1222	aaa ATPase
E4N65_05550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N65_05570	COG1136	(ABC) transporter
E4N65_05575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N65_05580	COG0193	aminoacyl-tRNA hydrolase activity
E4N65_05610	COG1509	lysine 2,3-aminomutase activity
E4N65_05615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N65_05630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N65_05640	COG1136	(ABC) transporter
E4N65_05645	COG0577	efflux transmembrane transporter activity
E4N65_05645	COG1136	(ABC) transporter
E4N65_05660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N65_05690	COG1473	amidohydrolase
E4N65_05695	COG1464	Belongs to the NlpA lipoprotein family
E4N65_05700	COG2011	ABC-type metal ion transport system permease component
E4N65_05705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4N65_05720	COG0149	triose-phosphate isomerase activity
E4N65_05725	COG1760	l-serine dehydratase
E4N65_05730	COG1760	l-serine dehydratase
E4N65_05760	COG1131	(ABC) transporter
E4N65_05770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N65_05775	COG0588	phosphoglycerate mutase activity
E4N65_05780	COG1543	Belongs to the glycosyl hydrolase 57 family
E4N65_05785	COG3330	Domain of unknown function (DUF4912)
E4N65_05795	COG0666	response to abiotic stimulus
E4N65_05800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N65_05805	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N65_05810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4N65_05825	COG0714	Associated with various cellular activities
E4N65_05830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N65_05850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N65_05860	COG1309	transcriptional regulator
E4N65_05875	COG0750	zinc metalloprotease
E4N65_05880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N65_05885	COG0575	Belongs to the CDS family
E4N65_05890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N65_05895	COG0233	cytoplasmic translational termination
E4N65_05900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N65_05905	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N65_05910	COG0424	maF-like protein
E4N65_05920	COG0442	prolyl-tRNA aminoacylation
E4N65_05935	COG5341	Protein conserved in bacteria
E4N65_05945	COG0835	chemotaxis
E4N65_05950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N65_05955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N65_05960	COG0497	DNA recombination
E4N65_05995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N65_06025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N65_06030	COG0791	NLP P60 protein
E4N65_06035	COG0318	PFAM AMP-dependent synthetase and ligase
E4N65_06045	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4N65_06050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N65_06055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N65_06065	COG0482	sulfurtransferase activity
E4N65_06090	COG0504	CTP synthase activity
E4N65_06095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N65_06095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N65_06095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N65_06120	COG3842	ATPase activity
E4N65_06125	COG4988	ABC transporter
E4N65_06130	COG1132	(ABC) transporter
E4N65_06135	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N65_06155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N65_06165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4N65_06170	COG0285	dihydrofolate synthase activity
E4N65_06175	COG0564	pseudouridine synthase activity
E4N65_06215	COG0330	HflC and HflK could
E4N65_06220	COG0330	HflC and HflK could
E4N65_06225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N65_06235	COG0455	bacterial-type flagellum organization
E4N65_06245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N65_06255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N65_06275	COG1301	dicarboxylic acid transport
E4N65_06320	COG1132	(ABC) transporter
E4N65_06320	COG2375	cellular response to nickel ion
E4N65_06330	COG1132	(ABC) transporter
E4N65_06335	COG2357	RelA SpoT domain protein
E4N65_06355	COG1131	(ABC) transporter
E4N65_06360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N65_06365	COG0563	adenylate kinase activity
E4N65_06375	COG0772	Belongs to the SEDS family
E4N65_06380	COG0768	penicillin binding
E4N65_06395	COG1077	Cell shape determining protein MreB Mrl
E4N65_06415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N65_06420	COG0358	DNA primase activity
E4N65_06445	COG3189	MarR family transcriptional regulator
E4N65_06495	COG0741	lytic transglycosylase activity
E4N65_06495	COG1388	LysM domain
E4N65_06500	COG2885	chlorophyll binding
E4N65_06510	COG3876	Protein conserved in bacteria
E4N65_06515	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N65_06520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N65_06535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N65_06560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N65_06575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N65_06580	COG0519	Catalyzes the synthesis of GMP from XMP
E4N65_06605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N65_06615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N65_06660	COG1129	ABC transporter
E4N65_06690	COG1132	(ABC) transporter
E4N65_06720	COG1132	(ABC) transporter
E4N65_06720	COG2375	cellular response to nickel ion
E4N65_06730	COG1129	ABC transporter
E4N65_06745	COG1917	Cupin 2, conserved barrel domain protein
E4N65_06745	COG4977	sequence-specific DNA binding
E4N65_06790	COG1484	DNA-dependent DNA replication
E4N65_06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N65_06870	COG2003	Belongs to the UPF0758 family
E4N65_06935	COG4115	mRNA cleavage
E4N65_06955	COG2948	multi-organism process
E4N65_06980	COG3451	type IV secretory pathway VirB4
E4N65_07005	COG4962	Type ii secretion system protein e
E4N65_07030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N65_07030	COG0551	DNA topoisomerase type I activity
E4N65_07050	COG1129	ABC transporter
E4N65_07055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N65_07055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N65_07075	COG0183	Belongs to the thiolase family
E4N65_07085	COG2304	oxidoreductase activity
E4N65_07100	COG0574	Belongs to the PEP-utilizing enzyme family
E4N65_07100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N65_07105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N65_07115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N65_07135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N65_07140	COG0166	Belongs to the GPI family
E4N65_07145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N65_07170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N65_07170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N65_07175	COG3118	belongs to the thioredoxin family
E4N65_07180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N65_07200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N65_07220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N65_07225	COG0484	heat shock protein binding
E4N65_07230	COG0528	UMP kinase activity
E4N65_07250	COG0215	cysteine-tRNA ligase activity
E4N65_07255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N65_07260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N65_07275	COG2201	protein-glutamate methylesterase activity
E4N65_07315	COG0126	phosphoglycerate kinase activity
E4N65_07325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N65_07360	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4N65_07375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N65_07375	COG0574	Belongs to the PEP-utilizing enzyme family
E4N65_07380	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N65_07385	COG0318	PFAM AMP-dependent synthetase and ligase
E4N65_07395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N65_07400	COG0426	domain, Protein
E4N65_07400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N65_07430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N65_07435	COG1480	7TM receptor with intracellular HD hydrolase
E4N65_07455	COG0494	nUDIX hydrolase
E4N65_07470	COG0735	belongs to the Fur family
E4N65_07480	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N65_07485	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N65_07490	COG1924	4 iron, 4 sulfur cluster binding
E4N65_07495	COG0786	glutamate:sodium symporter activity
E4N65_07500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4N65_07505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4N65_07510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4N65_07515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4N65_07530	COG0786	glutamate:sodium symporter activity
E4N65_07535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N65_07540	COG0840	transmembrane signaling receptor activity
E4N65_07555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N65_07560	COG0457	Tetratricopeptide repeat
E4N65_07570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N65_07580	COG2088	sporulation resulting in formation of a cellular spore
E4N65_07585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N65_07590	COG0537	adenosine 5'-monophosphoramidase activity
E4N65_07595	COG1022	Amp-dependent synthetase and ligase
E4N65_07605	COG0737	Belongs to the 5'-nucleotidase family
E4N65_07615	COG0514	ATP-dependent DNA helicase (RecQ)
E4N65_07625	COG0840	transmembrane signaling receptor activity
E4N65_07630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N65_07670	COG2226	methyltransferase
E4N65_07690	COG0488	(ABC) transporter
E4N65_07705	COG1136	(ABC) transporter
E4N65_07710	COG1136	(ABC) transporter
E4N65_07710	COG0577	efflux transmembrane transporter activity
E4N65_07725	COG3470	protein probably involved in high-affinity Fe2 transport
E4N65_07730	COG0672	)-iron permease
E4N65_07735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N65_07745	COG0475	glutathione-regulated potassium exporter activity
E4N65_07755	COG0758	DNA mediated transformation
E4N65_07760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N65_07760	COG0551	DNA topoisomerase type I activity
E4N65_07765	COG4974	Belongs to the 'phage' integrase family
E4N65_07790	COG2604	Protein of unknown function DUF115
E4N65_07810	COG0525	valine-tRNA ligase activity
E4N65_07815	COG1879	ABC-type sugar transport system periplasmic component
E4N65_07820	COG1129	ABC transporter
E4N65_07825	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N65_07835	COG0587	DNA-directed DNA polymerase activity
E4N65_07840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N65_07840	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N65_07850	COG1362	aminopeptidase activity
E4N65_07855	COG0557	exoribonuclease II activity
E4N65_07865	COG0534	Mate efflux family protein
E4N65_07870	COG1215	transferase activity, transferring glycosyl groups
E4N65_07880	COG1419	protein localization to endoplasmic reticulum
E4N65_07885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N65_07890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N65_07895	COG1684	flagellar biosynthetic protein fliR
E4N65_07900	COG1987	bacterial-type flagellum assembly
E4N65_07905	COG1338	Plays a role in the flagellum-specific transport system
E4N65_07915	COG1776	CheC inhibitor of MCP methylation
E4N65_07915	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N65_07920	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N65_07925	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N65_07930	COG1360	Flagellar Motor Protein
E4N65_07935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N65_07950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N65_08045	COG1132	(ABC) transporter
E4N65_08050	COG1132	(ABC) transporter
E4N65_08050	COG2375	cellular response to nickel ion
E4N65_08060	COG0698	ribose 5-phosphate isomerase
E4N65_08075	COG1979	alcohol dehydrogenase
E4N65_08090	COG0210	DNA helicase
E4N65_08100	COG3833	ABC-type maltose transport systems, permease component
E4N65_08105	COG1175	transmembrane transport
E4N65_08120	COG2182	Extracellular solute-binding protein
E4N65_08125	COG1523	belongs to the glycosyl hydrolase 13 family
E4N65_08130	COG2703	oxygen carrier activity
E4N65_08185	COG0813	purine-nucleoside phosphorylase activity
E4N65_08200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N65_08205	COG3639	organic phosphonate transmembrane transporter activity
E4N65_08225	COG1187	pseudouridine synthase activity
E4N65_08245	COG1129	ABC transporter
E4N65_08250	COG1609	Transcriptional regulator
E4N65_08260	COG0546	phosphoglycolate phosphatase activity
E4N65_08270	COG0840	transmembrane signaling receptor activity
E4N65_08285	COG1253	flavin adenine dinucleotide binding
E4N65_08290	COG0840	transmembrane signaling receptor activity
E4N65_08305	COG0756	dUTP diphosphatase activity
E4N65_08310	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N65_08320	COG0196	riboflavin kinase activity
E4N65_08330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N65_08335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N65_08345	COG0779	Required for maturation of 30S ribosomal subunits
E4N65_08365	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4N65_08365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4N65_08375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N65_08380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N65_08390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N65_08395	COG1047	Peptidyl-prolyl cis-trans
E4N65_08410	COG0251	oxidation-reduction process
E4N65_08440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N65_08450	COG2226	methyltransferase
E4N65_08470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N65_08475	COG1120	ATPase activity
E4N65_08490	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N65_08500	COG4786	Flagellar basal body rod
E4N65_08525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N65_08540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N65_08550	COG1012	belongs to the aldehyde dehydrogenase family
E4N65_08555	COG1960	acyl-CoA dehydrogenase activity
E4N65_08575	COG2887	Belongs to the helicase family. UvrD subfamily
E4N65_08585	COG0300	oxidoreductase activity
E4N65_08590	COG2885	chlorophyll binding
E4N65_08615	COG0840	transmembrane signaling receptor activity
E4N65_08620	COG0681	Belongs to the peptidase S26 family
E4N65_08640	COG0740	serine-type endopeptidase activity
E4N65_08645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4N65_08660	COG1570	exodeoxyribonuclease VII activity
E4N65_08695	COG0719	Fe-S assembly protein
E4N65_08705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N65_08715	COG1692	metallophosphoesterase
E4N65_08720	COG3118	belongs to the thioredoxin family
E4N65_08735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N65_08795	COG1733	regulation of RNA biosynthetic process
E4N65_08810	COG0017	Asparaginyl-tRNA synthetase
E4N65_08815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N65_08820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N65_08830	COG1288	antiporter activity
E4N65_08835	COG0549	Belongs to the carbamate kinase family
E4N65_08840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N65_08845	COG2235	arginine
E4N65_08860	COG0018	arginyl-trna synthetase
E4N65_08865	COG0481	GTPase activity
E4N65_08880	COG2267	carboxylic ester hydrolase activity
E4N65_08900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N65_08910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N65_08915	COG0740	serine-type endopeptidase activity
E4N65_08920	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N65_08965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N65_08980	COG0534	Mate efflux family protein
E4N65_09000	COG1102	Psort location Cytoplasmic, score
E4N65_09010	COG0617	tRNA 3'-terminal CCA addition
E4N65_09025	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4N65_09030	COG1111	helicase
E4N65_09030	COG1205	dead DEAH box helicase
E4N65_09055	COG0484	heat shock protein binding
E4N65_09060	COG0443	Heat shock 70 kDa protein
E4N65_09065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N65_09080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N65_09100	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N65_09110	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N65_09110	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N65_09110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N65_09110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N65_09115	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N65_09135	COG1846	Transcriptional regulator
E4N65_09155	COG3842	ATPase activity
E4N65_09160	COG0483	inositol monophosphate 1-phosphatase activity
E4N65_09165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N65_09170	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N65_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4N65_09235	COG3321	synthase
E4N65_09235	COG4221	oxidoreductase activity
E4N65_09235	COG0604	alcohol dehydrogenase
E4N65_09245	COG3340	Belongs to the peptidase S51 family
E4N65_09250	COG1881	PFAM PEBP family protein
E4N65_09255	COG0346	lactoylglutathione lyase activity
E4N65_09260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N65_09270	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N65_09280	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N65_09285	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N65_09290	COG1394	ATPase activity, coupled to movement of substances
E4N65_09295	COG1269	ATP hydrolysis coupled proton transport
E4N65_09315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N65_09325	COG0840	transmembrane signaling receptor activity
E4N65_09345	COG1199	ATP-dependent helicase activity
E4N65_09355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N65_09365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N65_09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N65_09395	COG2207	Transcriptional regulator
E4N65_09395	COG3708	Transcriptional regulator
E4N65_09405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N65_09410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N65_09415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4N65_09420	COG0402	S-adenosylhomocysteine deaminase activity
E4N65_09445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N65_09450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N65_09460	COG0457	Tetratricopeptide repeat
E4N65_09465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N65_09490	COG0494	nUDIX hydrolase
E4N65_09775	COG0681	Belongs to the peptidase S26 family
E4N65_09780	COG0768	penicillin binding
E4N65_09785	COG2604	Protein of unknown function DUF115
E4N65_09800	COG0670	Belongs to the BI1 family
E4N65_09810	COG0180	Tryptophanyl-tRNA synthetase
E4N65_09815	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N65_09835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N65_09855	COG1191	sigma factor activity
E4N65_09905	COG3052	prosthetic group binding
E4N65_09920	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N65_09930	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N65_09930	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
E4N65_09955	COG2217	Heavy metal translocating P-type atpase
E4N65_09970	COG1254	Belongs to the acylphosphatase family
E4N65_09990	COG1193	negative regulation of DNA recombination
E4N65_10005	COG0433	COG0433 Predicted ATPase
E4N65_10015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N65_10020	COG1722	exodeoxyribonuclease VII activity
E4N65_10060	COG1733	regulation of RNA biosynthetic process
E4N65_10075	COG0698	ribose 5-phosphate isomerase
E4N65_10135	COG3093	addiction module antidote protein HigA
E4N65_10140	COG3549	Plasmid maintenance system killer
E4N65_10165	COG0653	protein targeting
E4N65_10180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N65_10195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N65_10200	COG2801	Transposase and inactivated derivatives
E4N65_10210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N65_10215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N65_10220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N65_10225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N65_10230	COG2878	Part of a membrane complex involved in electron transport
E4N65_10230	COG1245	4Fe-4S binding domain
E4N65_10235	COG4657	Part of a membrane complex involved in electron transport
E4N65_10240	COG4660	Part of a membrane complex involved in electron transport
E4N65_10245	COG4659	FMN binding
E4N65_10250	COG4658	electron transport chain
E4N65_10255	COG4656	Part of a membrane complex involved in electron transport
E4N65_10260	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N65_10265	COG0511	ligase activity, forming carbon-carbon bonds
E4N65_10275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N65_10280	COG0825	malonyl-CoA metabolic process
E4N65_10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N65_10455	COG1193	negative regulation of DNA recombination
E4N65_10465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N65_10510	COG0629	single-stranded DNA binding
E4N65_10515	COG0281	malic enzyme
E4N65_10520	COG0039	L-malate dehydrogenase activity
E4N65_10570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N65_10580	COG0513	Belongs to the DEAD box helicase family
E4N65_10585	COG0395	ABC-type sugar transport system, permease component
E4N65_10590	COG1175	transmembrane transport
E4N65_10605	COG1070	Carbohydrate kinase
E4N65_10620	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4N65_10630	COG1879	ABC-type sugar transport system periplasmic component
E4N65_10640	COG2011	ABC-type metal ion transport system permease component
E4N65_10650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N65_10655	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N65_10660	COG5002	protein histidine kinase activity
E4N65_10660	COG3850	Histidine kinase
E4N65_10680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N65_10680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N65_10690	COG0351	phosphomethylpyrimidine kinase
E4N65_10730	COG0737	Belongs to the 5'-nucleotidase family
E4N65_10740	COG0840	transmembrane signaling receptor activity
E4N65_10760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N65_10785	COG4974	Belongs to the 'phage' integrase family
E4N65_10810	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N65_10815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N65_10860	COG0739	heme binding
E4N65_10880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N65_10885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N65_10920	COG0826	peptidase U32
E4N65_10930	COG0822	iron-sulfur transferase activity
E4N65_10940	COG2255	four-way junction helicase activity
E4N65_10950	COG0445	tRNA wobble uridine modification
E4N65_10960	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N65_10975	COG1695	Transcriptional regulator
E4N65_10985	COG1983	PspC domain protein
E4N65_11045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N65_11050	COG1640	4-alpha-glucanotransferase
E4N65_11055	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
E4N65_11065	COG4452	Inner membrane protein CreD
E4N65_11070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N65_11090	COG0237	dephospho-CoA kinase activity
E4N65_11095	COG2885	chlorophyll binding
E4N65_11100	COG0739	heme binding
E4N65_11105	COG0840	transmembrane signaling receptor activity
E4N65_11110	COG1114	Component of the transport system for branched-chain amino acids
E4N65_11115	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N65_11120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N65_11130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N65_11135	COG0156	8-amino-7-oxononanoate synthase activity
E4N65_11175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N65_11180	COG1120	ATPase activity
E4N65_11210	COG1177	transmembrane transport
E4N65_11215	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4N65_11220	COG3842	ATPase activity
E4N65_11230	COG0205	6-phosphofructokinase activity
E4N65_11235	COG0516	GMP reductase activity
E4N65_11235	COG0517	IMP dehydrogenase activity
E4N65_11245	COG1028	Short-chain dehydrogenase reductase Sdr
E4N65_11250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N65_11255	COG2204	response regulator
E4N65_11265	COG3177	Filamentation induced by cAMP protein fic
E4N65_11395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N65_11400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N65_11420	COG1686	Belongs to the peptidase S11 family
E4N65_11425	COG0739	heme binding
E4N65_11465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N65_11470	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N65_11480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N65_11500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N65_11505	COG0592	DNA-directed DNA polymerase activity
E4N65_11510	COG2089	acid synthase
E4N65_11600	COG0863	Belongs to the N(4) N(6)-methyltransferase family
E4N65_11615	COG1757	Na H antiporter
E4N65_11620	COG5001	Diguanylate cyclase
E4N65_11625	COG3706	GGDEF domain
E4N65_11645	COG0484	heat shock protein binding
E4N65_11650	COG0024	Methionine aminopeptidase
E4N65_11655	COG1054	Belongs to the UPF0176 family
E4N65_11680	COG0488	(ABC) transporter
E4N65_11710	COG0425	Belongs to the sulfur carrier protein TusA family
E4N65_11780	COG0701	Predicted permease
E4N65_11785	COG0116	Belongs to the methyltransferase superfamily
E4N65_11795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N65_11795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N65_11820	COG2949	membrane
E4N65_11825	COG0584	glycerophosphoryl diester phosphodiesterase
E4N65_11835	COG0423	glycine-tRNA ligase activity
E4N65_11840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N65_11855	COG2183	response to ionizing radiation
E4N65_11860	COG0012	GTP binding
E4N65_11865	COG0326	Molecular chaperone. Has ATPase activity
E4N65_11870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N65_11890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N65_11895	COG0640	Transcriptional regulator
E4N65_11900	COG2217	Heavy metal translocating P-type atpase
E4N65_11925	COG1132	(ABC) transporter
E4N65_11930	COG1132	(ABC) transporter
E4N65_11945	COG1129	ABC transporter
E4N65_11950	COG1132	(ABC) transporter
E4N65_11955	COG1132	(ABC) transporter
E4N65_11960	COG1309	transcriptional regulator
E4N65_11965	COG1162	GTPase activity
E4N65_11975	COG1132	(ABC) transporter
E4N65_11985	COG2378	regulation of single-species biofilm formation
E4N65_11990	COG1002	Type II restriction enzyme, methylase subunits
E4N65_12035	COG4115	mRNA cleavage
E4N65_12040	COG1132	(ABC) transporter
E4N65_12050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N65_12085	COG0577	efflux transmembrane transporter activity
E4N65_12085	COG1136	(ABC) transporter
E4N65_12090	COG0577	efflux transmembrane transporter activity
E4N65_12090	COG1136	(ABC) transporter
E4N65_12095	COG1136	(ABC) transporter
E4N65_12100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N65_12115	COG1956	GAF domain-containing protein
E4N65_12125	COG0716	FMN binding
E4N65_12130	COG0019	diaminopimelate decarboxylase activity
E4N65_12155	COG2211	Major facilitator Superfamily
E4N65_12160	COG4750	Nucleotidyl transferase
E4N65_12170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N65_12180	COG3842	ATPase activity
E4N65_12185	COG1178	ABC-type Fe3 transport system permease component
E4N65_12190	COG3842	ATPase activity