locus-tag	class	description
E4N66_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N66_00015	COG1373	ATPase (AAA superfamily
E4N66_00040	COG2801	Transposase and inactivated derivatives
E4N66_00045	COG2217	Heavy metal translocating P-type atpase
E4N66_00050	COG0640	Transcriptional regulator
E4N66_00055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N66_00090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N66_00095	COG0326	Molecular chaperone. Has ATPase activity
E4N66_00105	COG2183	response to ionizing radiation
E4N66_00110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N66_00115	COG0423	glycine-tRNA ligase activity
E4N66_00125	COG0584	glycerophosphoryl diester phosphodiesterase
E4N66_00130	COG2949	membrane
E4N66_00155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N66_00155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N66_00165	COG0116	Belongs to the methyltransferase superfamily
E4N66_00170	COG0701	Predicted permease
E4N66_00190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4N66_00235	COG0425	Belongs to the sulfur carrier protein TusA family
E4N66_00265	COG0488	(ABC) transporter
E4N66_00290	COG1054	Belongs to the UPF0176 family
E4N66_00295	COG0024	Methionine aminopeptidase
E4N66_00300	COG0484	heat shock protein binding
E4N66_00320	COG3706	GGDEF domain
E4N66_00325	COG5001	Diguanylate cyclase
E4N66_00330	COG1757	Na H antiporter
E4N66_00380	COG2089	acid synthase
E4N66_00385	COG0592	DNA-directed DNA polymerase activity
E4N66_00390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N66_00410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N66_00435	COG2378	regulation of single-species biofilm formation
E4N66_00445	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N66_00450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N66_00455	COG0739	heme binding
E4N66_00460	COG1686	Belongs to the peptidase S11 family
E4N66_00480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N66_00485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N66_00565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N66_00610	COG2204	response regulator
E4N66_00615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N66_00620	COG1028	Short-chain dehydrogenase reductase Sdr
E4N66_00630	COG0517	IMP dehydrogenase activity
E4N66_00630	COG0516	GMP reductase activity
E4N66_00635	COG0205	6-phosphofructokinase activity
E4N66_00645	COG3842	ATPase activity
E4N66_00650	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4N66_00655	COG1177	transmembrane transport
E4N66_00685	COG1120	ATPase activity
E4N66_00690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N66_00695	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E4N66_00730	COG0156	8-amino-7-oxononanoate synthase activity
E4N66_00735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N66_00745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N66_00750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N66_00755	COG1114	Component of the transport system for branched-chain amino acids
E4N66_00760	COG0840	transmembrane signaling receptor activity
E4N66_00765	COG0739	heme binding
E4N66_00770	COG2885	chlorophyll binding
E4N66_00775	COG0237	dephospho-CoA kinase activity
E4N66_00795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N66_00800	COG4452	Inner membrane protein CreD
E4N66_00810	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
E4N66_00815	COG1640	4-alpha-glucanotransferase
E4N66_00820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N66_00880	COG1983	PspC domain protein
E4N66_00890	COG1695	Transcriptional regulator
E4N66_00905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N66_00915	COG0445	tRNA wobble uridine modification
E4N66_00925	COG2255	four-way junction helicase activity
E4N66_00935	COG0822	iron-sulfur transferase activity
E4N66_00945	COG0826	peptidase U32
E4N66_00995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N66_01000	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N66_01015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N66_01070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N66_01075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N66_01100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N66_01125	COG0840	transmembrane signaling receptor activity
E4N66_01135	COG0737	Belongs to the 5'-nucleotidase family
E4N66_01175	COG5433	transposase activity
E4N66_01185	COG0351	phosphomethylpyrimidine kinase
E4N66_01195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N66_01195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N66_01210	COG0745	RESPONSE REGULATOR receiver
E4N66_01215	COG3850	Histidine kinase
E4N66_01215	COG5002	protein histidine kinase activity
E4N66_01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N66_01235	COG2011	ABC-type metal ion transport system permease component
E4N66_01245	COG1879	ABC-type sugar transport system periplasmic component
E4N66_01255	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4N66_01270	COG1070	Carbohydrate kinase
E4N66_01285	COG1175	transmembrane transport
E4N66_01290	COG0395	ABC-type sugar transport system, permease component
E4N66_01295	COG0513	Belongs to the DEAD box helicase family
E4N66_01305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N66_01350	COG0039	L-malate dehydrogenase activity
E4N66_01355	COG0281	malic enzyme
E4N66_01365	COG0629	single-stranded DNA binding
E4N66_01410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N66_01420	COG1193	negative regulation of DNA recombination
E4N66_01445	COG0613	PHP domain protein
E4N66_01455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N66_01630	COG0825	malonyl-CoA metabolic process
E4N66_01635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N66_01650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N66_01655	COG4656	Part of a membrane complex involved in electron transport
E4N66_01660	COG4658	electron transport chain
E4N66_01665	COG4659	FMN binding
E4N66_01670	COG4660	Part of a membrane complex involved in electron transport
E4N66_01675	COG4657	Part of a membrane complex involved in electron transport
E4N66_01680	COG1245	4Fe-4S binding domain
E4N66_01680	COG2878	Part of a membrane complex involved in electron transport
E4N66_01685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N66_01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N66_01695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N66_01700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N66_01710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N66_01725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N66_01740	COG0653	protein targeting
E4N66_01795	COG0698	ribose 5-phosphate isomerase
E4N66_01805	COG1733	regulation of RNA biosynthetic process
E4N66_01845	COG1722	exodeoxyribonuclease VII activity
E4N66_01850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N66_01860	COG0433	COG0433 Predicted ATPase
E4N66_01875	COG1193	negative regulation of DNA recombination
E4N66_01895	COG1254	Belongs to the acylphosphatase family
E4N66_01910	COG2217	Heavy metal translocating P-type atpase
E4N66_01935	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
E4N66_01935	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N66_01945	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N66_01960	COG3052	prosthetic group binding
E4N66_01965	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N66_02005	COG1191	sigma factor activity
E4N66_02025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N66_02045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N66_02050	COG0180	Tryptophanyl-tRNA synthetase
E4N66_02060	COG0670	Belongs to the BI1 family
E4N66_02080	COG2604	Protein of unknown function DUF115
E4N66_02085	COG0768	penicillin binding
E4N66_02090	COG0681	Belongs to the peptidase S26 family
E4N66_02430	COG0494	nUDIX hydrolase
E4N66_02455	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N66_02460	COG0457	Tetratricopeptide repeat
E4N66_02470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N66_02475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N66_02500	COG0732	type I restriction modification DNA specificity domain
E4N66_02555	COG0402	S-adenosylhomocysteine deaminase activity
E4N66_02560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4N66_02565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N66_02570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N66_02580	COG2207	Transcriptional regulator
E4N66_02580	COG3708	Transcriptional regulator
E4N66_02615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N66_02630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N66_02640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N66_02650	COG1199	ATP-dependent helicase activity
E4N66_02670	COG0840	transmembrane signaling receptor activity
E4N66_02680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N66_02700	COG1269	ATP hydrolysis coupled proton transport
E4N66_02705	COG1394	ATPase activity, coupled to movement of substances
E4N66_02710	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N66_02715	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N66_02725	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N66_02750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N66_02755	COG0346	lactoylglutathione lyase activity
E4N66_02760	COG1881	PFAM PEBP family protein
E4N66_02765	COG3340	Belongs to the peptidase S51 family
E4N66_02790	COG4221	oxidoreductase activity
E4N66_02790	COG3321	synthase
E4N66_02790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4N66_02790	COG0604	alcohol dehydrogenase
E4N66_02820	COG2267	carboxylic ester hydrolase activity
E4N66_02855	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N66_02860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N66_02915	COG4585	Histidine kinase
E4N66_02930	COG0483	inositol monophosphate 1-phosphatase activity
E4N66_02935	COG3842	ATPase activity
E4N66_02950	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N66_02950	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N66_02950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N66_02950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N66_02960	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N66_02970	COG1175	transmembrane transport
E4N66_02975	COG0395	ABC-type sugar transport system, permease component
E4N66_02985	COG3250	beta-galactosidase activity
E4N66_02995	COG0395	ABC-type sugar transport system, permease component
E4N66_03010	COG1609	Transcriptional regulator
E4N66_03030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N66_03045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N66_03050	COG0443	Heat shock 70 kDa protein
E4N66_03055	COG0484	heat shock protein binding
E4N66_03085	COG3177	Filamentation induced by cAMP protein fic
E4N66_03105	COG0617	tRNA 3'-terminal CCA addition
E4N66_03115	COG1102	Psort location Cytoplasmic, score
E4N66_03135	COG0534	Mate efflux family protein
E4N66_03150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N66_03225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N66_03250	COG2267	carboxylic ester hydrolase activity
E4N66_03325	COG0740	serine-type endopeptidase activity
E4N66_03365	COG2267	carboxylic ester hydrolase activity
E4N66_03380	COG0481	GTPase activity
E4N66_03385	COG0018	arginyl-trna synthetase
E4N66_03400	COG2235	arginine
E4N66_03405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N66_03410	COG0549	Belongs to the carbamate kinase family
E4N66_03415	COG1288	antiporter activity
E4N66_03425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N66_03430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N66_03435	COG0017	Asparaginyl-tRNA synthetase
E4N66_03470	COG2161	toxin-antitoxin pair type II binding
E4N66_03505	COG2801	Transposase and inactivated derivatives
E4N66_03515	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N66_03565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N66_03580	COG3118	belongs to the thioredoxin family
E4N66_03585	COG1692	metallophosphoesterase
E4N66_03590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N66_03600	COG0719	Fe-S assembly protein
E4N66_03625	COG1570	exodeoxyribonuclease VII activity
E4N66_03650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4N66_03655	COG0740	serine-type endopeptidase activity
E4N66_03675	COG0681	Belongs to the peptidase S26 family
E4N66_03705	COG2885	chlorophyll binding
E4N66_03710	COG0300	oxidoreductase activity
E4N66_03720	COG2887	Belongs to the helicase family. UvrD subfamily
E4N66_03750	COG1960	acyl-CoA dehydrogenase activity
E4N66_03755	COG1012	belongs to the aldehyde dehydrogenase family
E4N66_03765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N66_03780	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N66_03795	COG1061	Type III restriction enzyme res subunit
E4N66_03800	COG4786	Flagellar basal body rod
E4N66_03810	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N66_03825	COG1120	ATPase activity
E4N66_03830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N66_03850	COG2226	methyltransferase
E4N66_03860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N66_03890	COG0251	oxidation-reduction process
E4N66_03905	COG1047	Peptidyl-prolyl cis-trans
E4N66_03910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N66_03920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N66_03925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N66_03935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4N66_03935	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4N66_03955	COG0779	Required for maturation of 30S ribosomal subunits
E4N66_03965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N66_03970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N66_03980	COG0196	riboflavin kinase activity
E4N66_03990	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N66_03995	COG0756	dUTP diphosphatase activity
E4N66_04010	COG0840	transmembrane signaling receptor activity
E4N66_04015	COG1253	flavin adenine dinucleotide binding
E4N66_04030	COG3290	protein histidine kinase activity
E4N66_04030	COG0840	transmembrane signaling receptor activity
E4N66_04040	COG0546	phosphoglycolate phosphatase activity
E4N66_04050	COG1609	Transcriptional regulator
E4N66_04055	COG1129	ABC transporter
E4N66_04075	COG1187	pseudouridine synthase activity
E4N66_04095	COG3639	organic phosphonate transmembrane transporter activity
E4N66_04100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N66_04115	COG0813	purine-nucleoside phosphorylase activity
E4N66_04165	COG2703	oxygen carrier activity
E4N66_04170	COG1523	belongs to the glycosyl hydrolase 13 family
E4N66_04175	COG2182	Extracellular solute-binding protein
E4N66_04185	COG1175	transmembrane transport
E4N66_04190	COG3833	ABC-type maltose transport systems, permease component
E4N66_04215	COG0732	type I restriction modification DNA specificity domain
E4N66_04225	COG4974	Belongs to the 'phage' integrase family
E4N66_04250	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4N66_04260	COG1979	alcohol dehydrogenase
E4N66_04270	COG1309	transcriptional regulator
E4N66_04275	COG5433	transposase activity
E4N66_04300	COG0698	ribose 5-phosphate isomerase
E4N66_04315	COG1132	(ABC) transporter
E4N66_04405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N66_04420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N66_04425	COG1360	Flagellar Motor Protein
E4N66_04430	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N66_04435	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N66_04440	COG1776	CheC inhibitor of MCP methylation
E4N66_04440	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N66_04450	COG1338	Plays a role in the flagellum-specific transport system
E4N66_04455	COG1987	bacterial-type flagellum assembly
E4N66_04460	COG1684	flagellar biosynthetic protein fliR
E4N66_04465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N66_04470	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N66_04475	COG1419	protein localization to endoplasmic reticulum
E4N66_04485	COG1215	transferase activity, transferring glycosyl groups
E4N66_04490	COG0534	Mate efflux family protein
E4N66_04500	COG0557	exoribonuclease II activity
E4N66_04515	COG1362	aminopeptidase activity
E4N66_04525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N66_04525	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N66_04530	COG0587	DNA-directed DNA polymerase activity
E4N66_04540	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N66_04545	COG1129	ABC transporter
E4N66_04550	COG1879	ABC-type sugar transport system periplasmic component
E4N66_04555	COG0525	valine-tRNA ligase activity
E4N66_04575	COG2604	Protein of unknown function DUF115
E4N66_04600	COG4974	Belongs to the 'phage' integrase family
E4N66_04605	COG0551	DNA topoisomerase type I activity
E4N66_04605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N66_04610	COG0758	DNA mediated transformation
E4N66_04620	COG0475	glutathione-regulated potassium exporter activity
E4N66_04630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N66_04635	COG0672	)-iron permease
E4N66_04640	COG3470	protein probably involved in high-affinity Fe2 transport
E4N66_04655	COG1136	(ABC) transporter
E4N66_04655	COG0577	efflux transmembrane transporter activity
E4N66_04660	COG1136	(ABC) transporter
E4N66_04675	COG0488	(ABC) transporter
E4N66_04700	COG0693	protein deglycase activity
E4N66_04705	COG2226	methyltransferase
E4N66_04750	COG0596	Alpha beta hydrolase
E4N66_04760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N66_04765	COG0840	transmembrane signaling receptor activity
E4N66_04775	COG0514	ATP-dependent DNA helicase (RecQ)
E4N66_04785	COG0737	Belongs to the 5'-nucleotidase family
E4N66_04795	COG1022	Amp-dependent synthetase and ligase
E4N66_04800	COG0537	adenosine 5'-monophosphoramidase activity
E4N66_04805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N66_04810	COG2088	sporulation resulting in formation of a cellular spore
E4N66_04820	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N66_04830	COG0457	Tetratricopeptide repeat
E4N66_04835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N66_04850	COG0840	transmembrane signaling receptor activity
E4N66_04855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N66_04860	COG0786	glutamate:sodium symporter activity
E4N66_04875	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4N66_04880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4N66_04885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4N66_04890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4N66_04895	COG0786	glutamate:sodium symporter activity
E4N66_04900	COG1924	4 iron, 4 sulfur cluster binding
E4N66_04905	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N66_04910	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N66_04920	COG0735	belongs to the Fur family
E4N66_04935	COG0494	nUDIX hydrolase
E4N66_04955	COG1480	7TM receptor with intracellular HD hydrolase
E4N66_04960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N66_04990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N66_04990	COG0426	domain, Protein
E4N66_04995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N66_05005	COG0318	PFAM AMP-dependent synthetase and ligase
E4N66_05010	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N66_05015	COG0574	Belongs to the PEP-utilizing enzyme family
E4N66_05015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N66_05035	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4N66_05075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N66_05085	COG0126	phosphoglycerate kinase activity
E4N66_05125	COG2201	protein-glutamate methylesterase activity
E4N66_05140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N66_05145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N66_05150	COG0215	cysteine-tRNA ligase activity
E4N66_05170	COG0528	UMP kinase activity
E4N66_05175	COG0484	heat shock protein binding
E4N66_05180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N66_05200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N66_05220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N66_05225	COG3118	belongs to the thioredoxin family
E4N66_05230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N66_05230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N66_05255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N66_05260	COG0166	Belongs to the GPI family
E4N66_05265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N66_05285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N66_05295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N66_05300	COG0574	Belongs to the PEP-utilizing enzyme family
E4N66_05300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N66_05315	COG2304	oxidoreductase activity
E4N66_05325	COG0183	Belongs to the thiolase family
E4N66_05335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N66_05335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N66_05340	COG1129	ABC transporter
E4N66_05360	COG1917	Cupin 2, conserved barrel domain protein
E4N66_05360	COG4977	sequence-specific DNA binding
E4N66_05365	COG2207	Transcriptional regulator
E4N66_05365	COG4753	response regulator
E4N66_05375	COG1129	ABC transporter
E4N66_05385	COG1129	ABC transporter
E4N66_05405	COG0500	methyltransferase
E4N66_05420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N66_05425	COG1120	ATPase activity
E4N66_05435	COG1132	(ABC) transporter
E4N66_05435	COG2375	cellular response to nickel ion
E4N66_05460	COG4977	sequence-specific DNA binding
E4N66_05460	COG1917	Cupin 2, conserved barrel domain protein
E4N66_05470	COG2375	cellular response to nickel ion
E4N66_05470	COG1132	(ABC) transporter
E4N66_05480	COG1132	(ABC) transporter
E4N66_05485	COG1132	(ABC) transporter
E4N66_05490	COG2375	cellular response to nickel ion
E4N66_05490	COG1132	(ABC) transporter
E4N66_05500	COG2801	Transposase and inactivated derivatives
E4N66_05510	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N66_05555	COG1129	ABC transporter
E4N66_05610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N66_05620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N66_05645	COG0519	Catalyzes the synthesis of GMP from XMP
E4N66_05650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N66_05665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N66_05690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N66_05705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N66_05710	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N66_05715	COG3876	Protein conserved in bacteria
E4N66_05725	COG2885	chlorophyll binding
E4N66_05730	COG1388	LysM domain
E4N66_05730	COG0741	lytic transglycosylase activity
E4N66_05785	COG3189	MarR family transcriptional regulator
E4N66_05810	COG0358	DNA primase activity
E4N66_05815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N66_05835	COG1077	Cell shape determining protein MreB Mrl
E4N66_05850	COG0768	penicillin binding
E4N66_05855	COG0772	Belongs to the SEDS family
E4N66_05865	COG0563	adenylate kinase activity
E4N66_05870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N66_05875	COG1131	(ABC) transporter
E4N66_05895	COG2357	RelA SpoT domain protein
E4N66_05910	COG2375	cellular response to nickel ion
E4N66_05910	COG1132	(ABC) transporter
E4N66_05920	COG5433	transposase activity
E4N66_05925	COG2801	Transposase and inactivated derivatives
E4N66_05965	COG1846	Transcriptional regulator
E4N66_06005	COG1301	dicarboxylic acid transport
E4N66_06025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N66_06035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N66_06045	COG0455	bacterial-type flagellum organization
E4N66_06055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N66_06060	COG0330	HflC and HflK could
E4N66_06065	COG0330	HflC and HflK could
E4N66_06110	COG0564	pseudouridine synthase activity
E4N66_06115	COG0285	dihydrofolate synthase activity
E4N66_06120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4N66_06130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N66_06150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N66_06155	COG1132	(ABC) transporter
E4N66_06160	COG4988	ABC transporter
E4N66_06165	COG3842	ATPase activity
E4N66_06190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N66_06190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N66_06190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N66_06195	COG0504	CTP synthase activity
E4N66_06220	COG0482	sulfurtransferase activity
E4N66_06230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N66_06235	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N66_06240	COG1136	(ABC) transporter
E4N66_06240	COG0577	efflux transmembrane transporter activity
E4N66_06250	COG0318	PFAM AMP-dependent synthetase and ligase
E4N66_06255	COG0791	NLP P60 protein
E4N66_06260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N66_06290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N66_06330	COG0497	DNA recombination
E4N66_06335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N66_06340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N66_06345	COG0835	chemotaxis
E4N66_06355	COG5341	Protein conserved in bacteria
E4N66_06370	COG0442	prolyl-tRNA aminoacylation
E4N66_06380	COG0424	maF-like protein
E4N66_06385	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N66_06390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N66_06395	COG0233	cytoplasmic translational termination
E4N66_06400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N66_06405	COG0575	Belongs to the CDS family
E4N66_06410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N66_06415	COG0750	zinc metalloprotease
E4N66_06430	COG1309	transcriptional regulator
E4N66_06440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N66_06455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N66_06460	COG0714	Associated with various cellular activities
E4N66_06470	COG3800	Transcriptional regulator
E4N66_06470	COG1396	sequence-specific DNA binding
E4N66_06495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4N66_06500	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N66_06505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N66_06510	COG0666	response to abiotic stimulus
E4N66_06520	COG3330	Domain of unknown function (DUF4912)
E4N66_06525	COG1543	Belongs to the glycosyl hydrolase 57 family
E4N66_06530	COG0588	phosphoglycerate mutase activity
E4N66_06535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N66_06545	COG1131	(ABC) transporter
E4N66_06555	COG1086	Polysaccharide biosynthesis protein
E4N66_06575	COG1760	l-serine dehydratase
E4N66_06580	COG1760	l-serine dehydratase
E4N66_06585	COG0149	triose-phosphate isomerase activity
E4N66_06600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4N66_06605	COG2011	ABC-type metal ion transport system permease component
E4N66_06610	COG1464	Belongs to the NlpA lipoprotein family
E4N66_06615	COG1473	amidohydrolase
E4N66_06645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N66_06660	COG0577	efflux transmembrane transporter activity
E4N66_06660	COG1136	(ABC) transporter
E4N66_06665	COG1136	(ABC) transporter
E4N66_06675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N66_06690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N66_06695	COG1509	lysine 2,3-aminomutase activity
E4N66_06725	COG0193	aminoacyl-tRNA hydrolase activity
E4N66_06730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N66_06735	COG1136	(ABC) transporter
E4N66_06755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N66_06785	COG1222	aaa ATPase
E4N66_06800	COG1132	(ABC) transporter
E4N66_06820	COG1129	ABC transporter
E4N66_06825	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N66_06830	COG3681	Belongs to the UPF0597 family
E4N66_06845	COG1704	LemA family
E4N66_06855	COG1132	(ABC) transporter
E4N66_06860	COG1132	(ABC) transporter
E4N66_06865	COG1802	Transcriptional regulator
E4N66_06870	COG0632	four-way junction helicase activity
E4N66_06875	COG1739	Uncharacterized protein family UPF0029
E4N66_06880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N66_06885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N66_06895	COG0470	DNA polymerase III
E4N66_06910	COG0305	Participates in initiation and elongation during chromosome replication
E4N66_06915	COG0359	binds to the 23S rRNA
E4N66_06920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N66_06925	COG0629	single-stranded DNA binding
E4N66_06930	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N66_06935	COG0523	cobalamin synthesis protein
E4N66_06940	COG0534	Mate efflux family protein
E4N66_06955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N66_06960	COG1104	cysteine desulfurase activity
E4N66_06965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N66_06975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N66_07025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4N66_07030	COG1321	iron dependent repressor
E4N66_07035	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N66_07040	COG1121	(ABC) transporter
E4N66_07045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N66_07050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N66_07055	COG1683	Conserved Protein
E4N66_07065	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N66_07075	COG3290	protein histidine kinase activity
E4N66_07075	COG3829	transcription factor binding
E4N66_07085	COG3852	Histidine kinase
E4N66_07090	COG2204	response regulator
E4N66_07095	COG0823	Involved in the tonB-independent uptake of proteins
E4N66_07120	COG1454	alcohol dehydrogenase
E4N66_07135	COG0708	Exodeoxyribonuclease III
E4N66_07145	COG2832	Protein of unknown function (DUF454)
E4N66_07150	COG1137	ATPase activity
E4N66_07160	COG2217	Heavy metal translocating P-type atpase
E4N66_07170	COG0493	'glutamate synthase
E4N66_07170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N66_07175	COG0402	S-adenosylhomocysteine deaminase activity
E4N66_07190	COG1120	ATPase activity
E4N66_07195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N66_07225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N66_07230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N66_07260	COG0457	Tetratricopeptide repeat
E4N66_07265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N66_07270	COG0733	neurotransmitter:sodium symporter activity
E4N66_07275	COG1233	COG1233 Phytoene dehydrogenase and related
E4N66_07280	COG1562	ergosterol biosynthetic process
E4N66_07285	COG0170	dolichyl monophosphate biosynthetic process
E4N66_07290	COG1196	nuclear chromosome segregation
E4N66_07300	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N66_07305	COG0724	RNA recognition motif
E4N66_07320	COG4953	penicillin-binding protein 1C
E4N66_07325	COG1373	ATPase (AAA superfamily
E4N66_07510	COG3196	Protein conserved in bacteria
E4N66_07550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N66_07555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N66_07560	COG0142	geranyltranstransferase activity
E4N66_07570	COG1136	(ABC) transporter
E4N66_07585	COG0552	protein localization to endoplasmic reticulum
E4N66_07610	COG1122	ATPase activity
E4N66_07615	COG1268	BioY protein
E4N66_07625	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N66_07630	COG1876	peptidase activity
E4N66_07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N66_07665	COG0601	transmembrane transport
E4N66_07670	COG4608	Belongs to the ABC transporter superfamily
E4N66_07680	COG0561	phosphatase activity
E4N66_07685	COG0436	Aminotransferase
E4N66_07690	COG1522	sequence-specific DNA binding
E4N66_07700	COG0101	tRNA pseudouridine synthase activity
E4N66_07710	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N66_07720	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N66_07725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4N66_07735	COG3956	TIGRFAM MazG family protein
E4N66_07765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N66_07775	COG1747	RNA polymerase binding
E4N66_07775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N66_07785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N66_07810	COG1234	tRNA 3'-trailer cleavage
E4N66_07820	COG4254	PFAM FecR protein
E4N66_07830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N66_07835	COG0154	amidase activity
E4N66_07840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N66_07850	COG2211	Major facilitator Superfamily
E4N66_07870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N66_07880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N66_07900	COG0228	four-way junction DNA binding
E4N66_07905	COG1837	Belongs to the UPF0109 family
E4N66_07910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N66_07915	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N66_07920	COG0335	large ribosomal subunit rRNA binding
E4N66_07975	COG2801	Transposase and inactivated derivatives
E4N66_07980	COG0495	leucyl-tRNA aminoacylation
E4N66_07990	COG1773	rubredoxin
E4N66_08005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N66_08015	COG2358	TRAP transporter, solute receptor (TAXI family
E4N66_08030	COG0343	queuine tRNA-ribosyltransferase activity
E4N66_08045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4N66_08045	COG0116	Belongs to the methyltransferase superfamily
E4N66_08050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N66_08055	COG1413	lyase activity
E4N66_08070	COG1482	cell wall glycoprotein biosynthetic process
E4N66_08075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N66_08080	COG1573	uracil-dna glycosylase
E4N66_08090	COG2971	BadF BadG BcrA BcrD
E4N66_08115	COG1653	transport
E4N66_08120	COG1175	transmembrane transport
E4N66_08125	COG0395	ABC-type sugar transport system, permease component
E4N66_08135	COG4166	transmembrane transport
E4N66_08140	COG1620	l-lactate permease
E4N66_08145	COG1309	transcriptional regulator
E4N66_08155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N66_08165	COG1653	transport
E4N66_08195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N66_08200	COG1598	PFAM Uncharacterised protein family UPF0150
E4N66_08215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N66_08220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N66_08225	COG0297	glycogen (starch) synthase activity
E4N66_08235	COG0523	cobalamin synthesis protein
E4N66_08245	COG1272	protein, Hemolysin III
E4N66_08250	COG0254	rRNA binding
E4N66_08255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N66_08270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N66_08275	COG0776	regulation of translation
E4N66_08280	COG0268	Binds directly to 16S ribosomal RNA
E4N66_08300	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N66_08310	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N66_08320	COG0731	radical SAM domain protein
E4N66_08335	COG2201	protein-glutamate methylesterase activity
E4N66_08345	COG0835	chemotaxis
E4N66_08350	COG2198	Histidine kinase
E4N66_08350	COG0643	Histidine kinase
E4N66_08360	COG3118	belongs to the thioredoxin family
E4N66_08385	COG0617	tRNA 3'-terminal CCA addition
E4N66_08390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N66_08410	COG2388	GCN5-related N-acetyl-transferase
E4N66_08415	COG2885	chlorophyll binding
E4N66_08430	COG0583	DNA-binding transcription factor activity
E4N66_08435	COG0785	Cytochrome C biogenesis protein
E4N66_08450	COG2373	Large extracellular alpha-helical protein
E4N66_08475	COG3328	transposase activity
E4N66_08520	COG4209	transmembrane transport
E4N66_08525	COG0395	ABC-type sugar transport system, permease component
E4N66_08540	COG2226	methyltransferase
E4N66_08545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N66_08560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N66_08565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N66_08570	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E4N66_08595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4N66_08605	COG0569	domain protein
E4N66_08610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4N66_08630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N66_08635	COG1067	ATP-dependent peptidase activity
E4N66_08655	COG3620	sequence-specific DNA binding
E4N66_08665	COG3142	Participates in the control of copper homeostasis
E4N66_08685	COG2604	Protein of unknown function DUF115
E4N66_08695	COG0405	Gamma-glutamyltransferase
E4N66_08710	COG2186	Transcriptional regulator
E4N66_08715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4N66_08730	COG1070	Carbohydrate kinase
E4N66_08755	COG3549	Plasmid maintenance system killer
E4N66_08780	COG0302	gtp cyclohydrolase
E4N66_08780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4N66_08785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N66_08790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N66_08805	COG0564	pseudouridine synthase activity
E4N66_08820	COG2001	Belongs to the MraZ family
E4N66_08825	COG0275	rRNA processing
E4N66_08835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N66_08840	COG0772	Belongs to the SEDS family
E4N66_08845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4N66_08855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N66_08865	COG2233	PERMEase
E4N66_08870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N66_08890	COG0187	DNA topoisomerase II activity
E4N66_08895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N66_08935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N66_08965	COG3579	cysteine-type endopeptidase activity
E4N66_08970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N66_08975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N66_08980	COG1815	bacterial-type flagellum-dependent cell motility
E4N66_08995	COG1766	The M ring may be actively involved in energy transduction
E4N66_09005	COG1317	bacterial-type flagellum organization
E4N66_09010	COG1157	protein secretion by the type III secretion system
E4N66_09035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N66_09040	COG0840	transmembrane signaling receptor activity
E4N66_09045	COG0571	ribonuclease III activity
E4N66_09050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N66_09055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N66_09060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N66_09090	COG1921	L-seryl-tRNASec selenium transferase activity
E4N66_09100	COG0840	transmembrane signaling receptor activity
E4N66_09110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4N66_09110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4N66_09125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N66_09130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N66_09145	COG0395	ABC-type sugar transport system, permease component
E4N66_09150	COG1175	transmembrane transport
E4N66_09160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N66_09165	COG0328	RNA-DNA hybrid ribonuclease activity
E4N66_09170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N66_09175	COG0628	permease
E4N66_09180	COG0363	glucosamine-6-phosphate deaminase activity
E4N66_09185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4N66_09195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4N66_09200	COG0488	(ABC) transporter
E4N66_09230	COG3116	cell division
E4N66_09230	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N66_09235	COG0084	hydrolase, TatD family'
E4N66_09245	COG1464	Belongs to the NlpA lipoprotein family
E4N66_09260	COG1477	protein flavinylation
E4N66_09275	COG3588	fructose-bisphosphate aldolase
E4N66_09325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N66_09355	COG0322	excinuclease ABC activity
E4N66_09360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N66_09380	COG0301	tRNA thio-modification
E4N66_09390	COG2502	aspartate--ammonia ligase
E4N66_09415	COG0217	transcriptional regulatory protein
E4N66_09420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N66_09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N66_09445	COG0049	tRNA binding
E4N66_09460	COG0085	RNA polymerase activity
E4N66_09465	COG0222	ribosome binding
E4N66_09470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N66_09475	COG0081	regulation of translation
E4N66_09480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N66_09485	COG0250	Participates in transcription elongation, termination and antitermination
E4N66_09490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N66_09500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N66_09515	COG1438	arginine binding
E4N66_09520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N66_09535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4N66_09540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N66_09570	COG1129	ABC transporter
E4N66_09605	COG0616	signal peptide processing
E4N66_09610	COG4608	Belongs to the ABC transporter superfamily
E4N66_09615	COG0444	Belongs to the ABC transporter superfamily
E4N66_09620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N66_09625	COG0601	transmembrane transport
E4N66_09640	COG0826	peptidase U32
E4N66_09660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N66_09685	COG0739	heme binding
E4N66_09700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N66_09710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N66_09715	COG2911	Protein conserved in bacteria
E4N66_09720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N66_09730	COG0739	heme binding
E4N66_09745	COG1774	PSP1 C-terminal conserved region
E4N66_09760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N66_09765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N66_09770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N66_09785	COG0762	integral membrane protein
E4N66_09795	COG0427	acetyl-CoA hydrolase
E4N66_09800	COG1024	Enoyl-CoA hydratase
E4N66_09805	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4N66_09810	COG1309	transcriptional regulator
E4N66_09815	COG0574	Belongs to the PEP-utilizing enzyme family
E4N66_09815	COG3848	Pyruvate phosphate dikinase
E4N66_09820	COG0534	Mate efflux family protein
E4N66_09830	COG2801	Transposase and inactivated derivatives
E4N66_09865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N66_09870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N66_09875	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N66_09880	COG0167	dihydroorotate dehydrogenase activity
E4N66_09885	COG0543	2 iron, 2 sulfur cluster binding
E4N66_09890	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N66_09895	COG0540	Belongs to the ATCase OTCase family
E4N66_09900	COG0668	transmembrane transport
E4N66_09925	COG0500	methyltransferase
E4N66_09940	COG1132	(ABC) transporter
E4N66_09945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N66_09950	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N66_10005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4N66_10015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N66_10020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N66_10025	COG2203	Gaf domain
E4N66_10025	COG3706	GGDEF domain
E4N66_10025	COG4251	negative regulation of phosphorylation
E4N66_10025	COG5001	Diguanylate cyclase
E4N66_10030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N66_10035	COG0205	6-phosphofructokinase activity
E4N66_10040	COG0124	histidyl-tRNA synthetase
E4N66_10055	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N66_10065	COG0840	transmembrane signaling receptor activity
E4N66_10095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N66_10110	COG2770	Histidine kinase
E4N66_10110	COG3437	response regulator, receiver
E4N66_10115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N66_10120	COG0802	atpase or kinase
E4N66_10125	COG0564	pseudouridine synthase activity
E4N66_10135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N66_10150	COG0297	glycogen (starch) synthase activity
E4N66_10185	COG1027	Aspartate ammonia-lyase
E4N66_10190	COG0295	cytidine deaminase activity
E4N66_10200	COG0739	heme binding
E4N66_10230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4N66_10245	COG0556	nucleotide-excision repair
E4N66_10250	COG0709	Synthesizes selenophosphate from selenide and ATP
E4N66_10270	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N66_10275	COG3845	ABC transporter
E4N66_10280	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N66_10285	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N66_10345	COG1418	mRNA catabolic process
E4N66_10350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4N66_10360	COG1475	DNA binding
E4N66_10365	COG1192	Involved in chromosome partitioning
E4N66_10370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N66_10400	COG1393	Belongs to the ArsC family
E4N66_10440	COG1086	Polysaccharide biosynthesis protein
E4N66_10470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N66_10475	COG1083	cytidylyl-transferase
E4N66_10490	COG2089	acid synthase
E4N66_10500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4N66_10515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N66_10520	COG1086	Polysaccharide biosynthesis protein
E4N66_10535	COG1373	ATPase (AAA superfamily
E4N66_10570	COG1362	aminopeptidase activity
E4N66_10575	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N66_10620	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N66_10625	COG1966	Carbon starvation protein
E4N66_10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N66_10635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N66_10645	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N66_10655	COG3845	ABC transporter
E4N66_10660	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N66_10670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N66_10675	COG2801	Transposase and inactivated derivatives
E4N66_10680	COG3876	Protein conserved in bacteria
E4N66_10690	COG2239	Acts as a magnesium transporter
E4N66_10695	COG0170	dolichyl monophosphate biosynthetic process
E4N66_10705	COG2252	PERMEase
E4N66_10745	COG0733	neurotransmitter:sodium symporter activity
E4N66_10750	COG0457	Tetratricopeptide repeat
E4N66_10755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N66_10760	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N66_10770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N66_10775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N66_10790	COG0058	SHG alpha-glucan phosphorylase activity
E4N66_10800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N66_10810	COG1040	competence protein
E4N66_10815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N66_10820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N66_10825	COG1862	Preprotein translocase
E4N66_10830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N66_10840	COG1847	R3H domain protein
E4N66_10845	COG0706	membrane insertase activity
E4N66_10850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N66_10885	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N66_10890	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N66_10895	COG0492	ferredoxin-NADP+ reductase activity
E4N66_10900	COG0280	phosphate acetyltransferase
E4N66_10920	COG1151	hydroxylamine reductase activity
E4N66_10940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N66_10945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N66_10950	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N66_10950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N66_10965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N66_10980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N66_11025	COG0728	peptidoglycan biosynthetic process
E4N66_11040	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N66_11045	COG0420	3'-5' exonuclease activity
E4N66_11050	COG0419	ATPase involved in DNA repair
E4N66_11060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N66_11085	COG0588	phosphoglycerate mutase activity
E4N66_11090	COG0564	pseudouridine synthase activity
E4N66_11095	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4N66_11145	COG4443	Transcriptional Coactivator p15 (PC4)
E4N66_11150	COG0840	transmembrane signaling receptor activity
E4N66_11160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N66_11160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N66_11165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N66_11240	COG1647	Serine aminopeptidase, S33
E4N66_11250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N66_11260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N66_11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N66_11285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N66_11300	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N66_11305	COG1671	Belongs to the UPF0178 family
E4N66_11310	COG3437	response regulator, receiver
E4N66_11315	COG5433	transposase activity
E4N66_11320	COG1115	amino acid carrier protein
E4N66_11325	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N66_11335	COG5433	transposase activity
E4N66_11345	COG5016	pyruvate
E4N66_11345	COG0511	ligase activity, forming carbon-carbon bonds
E4N66_11365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N66_11380	COG0778	Nitroreductase
E4N66_11385	COG1131	(ABC) transporter
E4N66_11405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N66_11440	COG4656	Part of a membrane complex involved in electron transport
E4N66_11450	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4N66_11455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N66_11470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N66_11480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N66_11480	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N66_11495	COG1121	(ABC) transporter
E4N66_11500	COG1639	'signal transduction protein
E4N66_11505	COG0543	2 iron, 2 sulfur cluster binding
E4N66_11520	COG0733	neurotransmitter:sodium symporter activity
E4N66_11530	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N66_11535	COG1129	ABC transporter
E4N66_11540	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N66_11545	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N66_11555	COG4942	peptidase
E4N66_11570	COG3177	Filamentation induced by cAMP protein fic
E4N66_11580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N66_11585	COG1253	flavin adenine dinucleotide binding
E4N66_11590	COG4536	flavin adenine dinucleotide binding
E4N66_11600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4N66_11605	COG0542	response to heat
E4N66_11635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N66_11635	COG0551	DNA topoisomerase type I activity
E4N66_11660	COG4962	Type ii secretion system protein e
E4N66_11685	COG3451	type IV secretory pathway VirB4
E4N66_11710	COG2948	multi-organism process
E4N66_11795	COG2003	Belongs to the UPF0758 family
E4N66_11840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N66_11855	COG1484	DNA-dependent DNA replication
E4N66_11905	COG0564	pseudouridine synthase activity
E4N66_11910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N66_11920	COG0450	alkyl hydroperoxide reductase
E4N66_11925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N66_12000	COG2161	toxin-antitoxin pair type II binding
E4N66_12010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4N66_12020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N66_12055	COG0793	Belongs to the peptidase S41A family
E4N66_12085	COG0203	ribosomal protein L17
E4N66_12090	COG0202	RNA polymerase activity
E4N66_12095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N66_12105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N66_12115	COG0200	Binds to the 23S rRNA
E4N66_12125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N66_12135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N66_12140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N66_12150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N66_12155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N66_12160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N66_12165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N66_12170	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N66_12180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N66_12185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N66_12195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N66_12200	COG0089	rRNA binding
E4N66_12205	COG0088	Forms part of the polypeptide exit tunnel
E4N66_12210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N66_12215	COG0051	transcription antitermination factor activity, RNA binding
E4N66_12220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N66_12255	COG0741	lytic transglycosylase activity
E4N66_12260	COG1968	undecaprenyl-diphosphatase activity
E4N66_12265	COG1674	ftsk spoiiie
E4N66_12285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N66_12290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N66_12295	COG0084	hydrolase, TatD family'
E4N66_12305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N66_12360	COG0714	Associated with various cellular activities
E4N66_12490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N66_12585	COG1192	Involved in chromosome partitioning
E4N66_12735	COG0714	Associated with various cellular activities
E4N66_12745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4N66_12755	COG5433	transposase activity
E4N66_12770	COG1132	(ABC) transporter
E4N66_12775	COG1132	(ABC) transporter
E4N66_12790	COG1129	ABC transporter
E4N66_12795	COG1132	(ABC) transporter
E4N66_12800	COG1132	(ABC) transporter
E4N66_12805	COG1309	transcriptional regulator
E4N66_12810	COG1162	GTPase activity
E4N66_12820	COG1132	(ABC) transporter
E4N66_12835	COG4115	mRNA cleavage
E4N66_12840	COG1132	(ABC) transporter
E4N66_12850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N66_12885	COG0577	efflux transmembrane transporter activity
E4N66_12885	COG1136	(ABC) transporter
E4N66_12890	COG1136	(ABC) transporter
E4N66_12890	COG0577	efflux transmembrane transporter activity
E4N66_12895	COG1136	(ABC) transporter
E4N66_12900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N66_12915	COG1956	GAF domain-containing protein
E4N66_12925	COG0716	FMN binding
E4N66_12930	COG0019	diaminopimelate decarboxylase activity
E4N66_12945	COG1640	4-alpha-glucanotransferase
E4N66_12955	COG2211	Major facilitator Superfamily
E4N66_12960	COG4750	Nucleotidyl transferase
E4N66_12970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N66_12985	COG3842	ATPase activity
E4N66_12990	COG1178	ABC-type Fe3 transport system permease component
E4N66_12995	COG3842	ATPase activity