locus-tag	class	description
E4N69_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N69_00015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N69_00020	COG0156	8-amino-7-oxononanoate synthase activity
E4N69_00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N69_00070	COG1120	ATPase activity
E4N69_00075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N69_00090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N69_00095	COG0326	Molecular chaperone. Has ATPase activity
E4N69_00120	COG1162	GTPase activity
E4N69_00130	COG1132	(ABC) transporter
E4N69_00145	COG2378	regulation of single-species biofilm formation
E4N69_00175	COG4115	mRNA cleavage
E4N69_00180	COG1132	(ABC) transporter
E4N69_00190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N69_00225	COG2183	response to ionizing radiation
E4N69_00240	COG2949	membrane
E4N69_00275	COG0425	Belongs to the sulfur carrier protein TusA family
E4N69_00290	COG1012	belongs to the aldehyde dehydrogenase family
E4N69_00305	COG0673	inositol 2-dehydrogenase activity
E4N69_00310	COG0191	fructose-bisphosphate aldolase activity
E4N69_00315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N69_00325	COG1349	DNA-binding transcription factor activity
E4N69_00330	COG1879	ABC-type sugar transport system periplasmic component
E4N69_00335	COG1129	ABC transporter
E4N69_00340	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4N69_00345	COG0673	inositol 2-dehydrogenase activity
E4N69_00360	COG0438	transferase activity, transferring glycosyl groups
E4N69_00360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N69_00365	COG0488	(ABC) transporter
E4N69_00385	COG1054	Belongs to the UPF0176 family
E4N69_00390	COG0024	Methionine aminopeptidase
E4N69_00395	COG0484	heat shock protein binding
E4N69_00415	COG0739	heme binding
E4N69_00420	COG0534	Mate efflux family protein
E4N69_00435	COG1129	ABC transporter
E4N69_00520	COG0863	Belongs to the N(4) N(6)-methyltransferase family
E4N69_00565	COG1757	Na H antiporter
E4N69_00570	COG5001	Diguanylate cyclase
E4N69_00635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N69_00640	COG1917	Cupin 2, conserved barrel domain protein
E4N69_00640	COG4977	sequence-specific DNA binding
E4N69_00655	COG1129	ABC transporter
E4N69_00660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N69_00670	COG2211	Major facilitator Superfamily
E4N69_00680	COG1132	(ABC) transporter
E4N69_00685	COG1132	(ABC) transporter
E4N69_00690	COG2217	Heavy metal translocating P-type atpase
E4N69_00695	COG0640	Transcriptional regulator
E4N69_00710	COG2217	Heavy metal translocating P-type atpase
E4N69_00760	COG1191	sigma factor activity
E4N69_00780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N69_00835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N69_00840	COG0180	Tryptophanyl-tRNA synthetase
E4N69_00845	COG0670	Belongs to the BI1 family
E4N69_00880	COG2604	Protein of unknown function DUF115
E4N69_00885	COG0768	penicillin binding
E4N69_00890	COG0681	Belongs to the peptidase S26 family
E4N69_01250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N69_01260	COG0613	PHP domain protein
E4N69_01285	COG1193	negative regulation of DNA recombination
E4N69_01295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N69_01340	COG0629	single-stranded DNA binding
E4N69_01350	COG0281	malic enzyme
E4N69_01355	COG0039	L-malate dehydrogenase activity
E4N69_01395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N69_01405	COG0513	Belongs to the DEAD box helicase family
E4N69_01420	COG0395	ABC-type sugar transport system, permease component
E4N69_01425	COG1175	transmembrane transport
E4N69_01445	COG1070	Carbohydrate kinase
E4N69_01460	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4N69_01470	COG1879	ABC-type sugar transport system periplasmic component
E4N69_01480	COG2011	ABC-type metal ion transport system permease component
E4N69_01490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N69_01500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N69_01500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N69_01510	COG0351	phosphomethylpyrimidine kinase
E4N69_01585	COG0840	transmembrane signaling receptor activity
E4N69_01595	COG0825	malonyl-CoA metabolic process
E4N69_01600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N69_01615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N69_01620	COG4656	Part of a membrane complex involved in electron transport
E4N69_01625	COG4658	electron transport chain
E4N69_01630	COG4659	FMN binding
E4N69_01635	COG4660	Part of a membrane complex involved in electron transport
E4N69_01640	COG4657	Part of a membrane complex involved in electron transport
E4N69_01645	COG2878	Part of a membrane complex involved in electron transport
E4N69_01650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N69_01660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N69_01665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N69_01670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N69_01680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N69_01695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N69_01710	COG0653	protein targeting
E4N69_01715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N69_01720	COG0450	alkyl hydroperoxide reductase
E4N69_01730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N69_01745	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N69_01750	COG1671	Belongs to the UPF0178 family
E4N69_01755	COG3437	response regulator, receiver
E4N69_01760	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N69_01765	COG1115	amino acid carrier protein
E4N69_01775	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N69_01795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N69_01810	COG1131	(ABC) transporter
E4N69_01830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N69_01875	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4N69_01880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N69_01895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N69_01900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N69_01900	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N69_01915	COG1121	(ABC) transporter
E4N69_01920	COG1639	'signal transduction protein
E4N69_01925	COG0543	2 iron, 2 sulfur cluster binding
E4N69_01940	COG0733	neurotransmitter:sodium symporter activity
E4N69_01945	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N69_01955	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N69_01960	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N69_01965	COG3177	Filamentation induced by cAMP protein fic
E4N69_01980	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N69_01995	COG4536	flavin adenine dinucleotide binding
E4N69_02010	COG0542	response to heat
E4N69_02050	COG1414	Transcriptional regulator
E4N69_02060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N69_02070	COG0513	Belongs to the DEAD box helicase family
E4N69_02075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N69_02080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N69_02085	COG1028	Short-chain dehydrogenase reductase Sdr
E4N69_02090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N69_02100	COG1647	Serine aminopeptidase, S33
E4N69_02155	COG1309	transcriptional regulator
E4N69_02170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N69_02175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N69_02175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N69_02220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N69_02225	COG0706	membrane insertase activity
E4N69_02230	COG1847	R3H domain protein
E4N69_02240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N69_02245	COG1862	Preprotein translocase
E4N69_02250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N69_02255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N69_02260	COG1040	competence protein
E4N69_02270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N69_02280	COG0058	SHG alpha-glucan phosphorylase activity
E4N69_02295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N69_02300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N69_02310	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N69_02315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N69_02320	COG0457	Tetratricopeptide repeat
E4N69_02325	COG0733	neurotransmitter:sodium symporter activity
E4N69_02350	COG1102	Psort location Cytoplasmic, score
E4N69_02380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N69_02420	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N69_02425	COG0740	serine-type endopeptidase activity
E4N69_02430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N69_02440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N69_02460	COG0395	ABC-type sugar transport system, permease component
E4N69_02465	COG4209	transmembrane transport
E4N69_02500	COG1129	ABC transporter
E4N69_02555	COG0481	GTPase activity
E4N69_02580	COG0018	arginyl-trna synthetase
E4N69_02585	COG2235	arginine
E4N69_02590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N69_02595	COG0549	Belongs to the carbamate kinase family
E4N69_02600	COG1288	antiporter activity
E4N69_02605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N69_02610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N69_02615	COG0017	Asparaginyl-tRNA synthetase
E4N69_02700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N69_02705	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N69_02735	COG0747	negative chemotaxis
E4N69_02740	COG0601	transmembrane transport
E4N69_02755	COG4608	Belongs to the ABC transporter superfamily
E4N69_02760	COG1132	(ABC) transporter
E4N69_02765	COG1132	(ABC) transporter
E4N69_02800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N69_02805	COG1362	aminopeptidase activity
E4N69_02860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N69_02885	COG2244	polysaccharide biosynthetic process
E4N69_02965	COG1393	Belongs to the ArsC family
E4N69_03005	COG2361	Protein of unknown function DUF86
E4N69_03080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N69_03085	COG1192	Involved in chromosome partitioning
E4N69_03090	COG1475	DNA binding
E4N69_03100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4N69_03105	COG1418	mRNA catabolic process
E4N69_03135	COG2161	toxin-antitoxin pair type II binding
E4N69_03215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N69_03220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N69_03225	COG5001	Diguanylate cyclase
E4N69_03225	COG4251	negative regulation of phosphorylation
E4N69_03225	COG3706	GGDEF domain
E4N69_03225	COG2203	Gaf domain
E4N69_03230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N69_03235	COG0205	6-phosphofructokinase activity
E4N69_03240	COG0124	histidyl-tRNA synthetase
E4N69_03250	COG2204	response regulator
E4N69_03255	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N69_03265	COG0840	transmembrane signaling receptor activity
E4N69_03310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N69_03325	COG4786	Flagellar basal body rod
E4N69_03335	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N69_03350	COG1120	ATPase activity
E4N69_03355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N69_03370	COG2226	methyltransferase
E4N69_03380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N69_03410	COG0251	oxidation-reduction process
E4N69_03425	COG1047	Peptidyl-prolyl cis-trans
E4N69_03430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N69_03440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N69_03445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N69_03455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4N69_03455	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4N69_03475	COG0779	Required for maturation of 30S ribosomal subunits
E4N69_03485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N69_03490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N69_03500	COG0196	riboflavin kinase activity
E4N69_03510	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N69_03515	COG0756	dUTP diphosphatase activity
E4N69_03530	COG0840	transmembrane signaling receptor activity
E4N69_03535	COG1253	flavin adenine dinucleotide binding
E4N69_03560	COG0546	phosphoglycolate phosphatase activity
E4N69_03570	COG1609	Transcriptional regulator
E4N69_03575	COG1129	ABC transporter
E4N69_03595	COG0587	DNA-directed DNA polymerase activity
E4N69_03600	COG0762	integral membrane protein
E4N69_03615	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N69_03620	COG1129	ABC transporter
E4N69_03630	COG1879	ABC-type sugar transport system periplasmic component
E4N69_03640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N69_03650	COG0826	peptidase U32
E4N69_03665	COG0601	transmembrane transport
E4N69_03670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N69_03675	COG0444	Belongs to the ABC transporter superfamily
E4N69_03680	COG4608	Belongs to the ABC transporter superfamily
E4N69_03685	COG0616	signal peptide processing
E4N69_03725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N69_03730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4N69_03745	COG0322	excinuclease ABC activity
E4N69_03765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N69_03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N69_03810	COG0747	negative chemotaxis
E4N69_03825	COG1247	-acetyltransferase
E4N69_03830	COG0698	ribose 5-phosphate isomerase
E4N69_03840	COG1132	(ABC) transporter
E4N69_03840	COG2375	cellular response to nickel ion
E4N69_03845	COG1132	(ABC) transporter
E4N69_03915	COG3209	COG3209 Rhs family protein
E4N69_03925	COG3209	COG3209 Rhs family protein
E4N69_03975	COG0456	acetyltransferase
E4N69_03975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4N69_03985	COG4115	mRNA cleavage
E4N69_04030	COG1373	ATPase (AAA superfamily
E4N69_04040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N69_04055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N69_04060	COG1360	Flagellar Motor Protein
E4N69_04065	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N69_04070	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N69_04075	COG1776	CheC inhibitor of MCP methylation
E4N69_04075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N69_04085	COG1338	Plays a role in the flagellum-specific transport system
E4N69_04090	COG1987	bacterial-type flagellum assembly
E4N69_04095	COG1684	flagellar biosynthetic protein fliR
E4N69_04100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N69_04105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N69_04110	COG1419	protein localization to endoplasmic reticulum
E4N69_04120	COG0534	Mate efflux family protein
E4N69_04130	COG0557	exoribonuclease II activity
E4N69_04135	COG1362	aminopeptidase activity
E4N69_04145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N69_04145	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N69_04150	COG0525	valine-tRNA ligase activity
E4N69_04170	COG2604	Protein of unknown function DUF115
E4N69_04195	COG4974	Belongs to the 'phage' integrase family
E4N69_04200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N69_04200	COG0551	DNA topoisomerase type I activity
E4N69_04205	COG0758	DNA mediated transformation
E4N69_04215	COG0475	glutathione-regulated potassium exporter activity
E4N69_04220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N69_04225	COG0672	)-iron permease
E4N69_04230	COG3470	protein probably involved in high-affinity Fe2 transport
E4N69_04245	COG0577	efflux transmembrane transporter activity
E4N69_04245	COG1136	(ABC) transporter
E4N69_04250	COG1136	(ABC) transporter
E4N69_04260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N69_04265	COG3639	organic phosphonate transmembrane transporter activity
E4N69_04285	COG1187	pseudouridine synthase activity
E4N69_04290	COG0217	transcriptional regulatory protein
E4N69_04300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N69_04310	COG0813	purine-nucleoside phosphorylase activity
E4N69_04410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N69_04515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N69_04520	COG0187	DNA topoisomerase II activity
E4N69_04530	COG3588	fructose-bisphosphate aldolase
E4N69_04535	COG1979	alcohol dehydrogenase
E4N69_04540	COG1477	protein flavinylation
E4N69_04555	COG1464	Belongs to the NlpA lipoprotein family
E4N69_04565	COG0084	hydrolase, TatD family'
E4N69_04570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N69_04570	COG3116	cell division
E4N69_04600	COG0488	(ABC) transporter
E4N69_04605	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4N69_04615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4N69_04620	COG0363	glucosamine-6-phosphate deaminase activity
E4N69_04625	COG0628	permease
E4N69_04630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N69_04635	COG0328	RNA-DNA hybrid ribonuclease activity
E4N69_04640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N69_04650	COG1175	transmembrane transport
E4N69_04655	COG0395	ABC-type sugar transport system, permease component
E4N69_04675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N69_04680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N69_04700	COG0840	transmembrane signaling receptor activity
E4N69_04715	COG1921	L-seryl-tRNASec selenium transferase activity
E4N69_04745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N69_04750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N69_04755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N69_04760	COG0571	ribonuclease III activity
E4N69_04770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N69_04795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4N69_04800	COG1960	acyl-CoA dehydrogenase activity
E4N69_04810	COG1157	protein secretion by the type III secretion system
E4N69_04815	COG1317	bacterial-type flagellum organization
E4N69_04825	COG1766	The M ring may be actively involved in energy transduction
E4N69_04840	COG1815	bacterial-type flagellum-dependent cell motility
E4N69_04845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N69_04850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N69_04855	COG3579	cysteine-type endopeptidase activity
E4N69_04860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N69_04865	COG0166	Belongs to the GPI family
E4N69_04870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N69_04885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N69_04895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N69_04900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N69_04900	COG0574	Belongs to the PEP-utilizing enzyme family
E4N69_04915	COG2304	oxidoreductase activity
E4N69_04925	COG0183	Belongs to the thiolase family
E4N69_04935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N69_04935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N69_04940	COG3842	ATPase activity
E4N69_04950	COG0343	queuine tRNA-ribosyltransferase activity
E4N69_04970	COG2358	TRAP transporter, solute receptor (TAXI family
E4N69_04980	COG0708	Exodeoxyribonuclease III
E4N69_04990	COG2832	Protein of unknown function (DUF454)
E4N69_04995	COG1137	ATPase activity
E4N69_05010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N69_05010	COG0493	'glutamate synthase
E4N69_05020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4N69_05025	COG0402	S-adenosylhomocysteine deaminase activity
E4N69_05040	COG1120	ATPase activity
E4N69_05045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N69_05080	COG3620	sequence-specific DNA binding
E4N69_05085	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N69_05090	COG3421	Type III restriction
E4N69_05095	COG1509	lysine 2,3-aminomutase activity
E4N69_05100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N69_05115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N69_05120	COG0840	transmembrane signaling receptor activity
E4N69_05150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N69_05155	COG0617	tRNA 3'-terminal CCA addition
E4N69_05160	COG2703	oxygen carrier activity
E4N69_05165	COG1523	belongs to the glycosyl hydrolase 13 family
E4N69_05170	COG2182	Extracellular solute-binding protein
E4N69_05180	COG1175	transmembrane transport
E4N69_05185	COG3833	ABC-type maltose transport systems, permease component
E4N69_05215	COG3118	belongs to the thioredoxin family
E4N69_05225	COG0643	Histidine kinase
E4N69_05225	COG2198	Histidine kinase
E4N69_05230	COG0835	chemotaxis
E4N69_05240	COG2201	protein-glutamate methylesterase activity
E4N69_05255	COG0731	radical SAM domain protein
E4N69_05275	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N69_05295	COG0268	Binds directly to 16S ribosomal RNA
E4N69_05305	COG0776	regulation of translation
E4N69_05310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N69_05320	COG1546	Belongs to the CinA family
E4N69_05320	COG1058	Belongs to the CinA family
E4N69_05325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N69_05330	COG0254	rRNA binding
E4N69_05335	COG1272	protein, Hemolysin III
E4N69_05350	COG1131	(ABC) transporter
E4N69_05385	COG1136	(ABC) transporter
E4N69_05435	COG1129	ABC transporter
E4N69_05440	COG0346	lactoylglutathione lyase activity
E4N69_05450	COG1881	PFAM PEBP family protein
E4N69_05455	COG3340	Belongs to the peptidase S51 family
E4N69_05480	COG0656	L-ascorbic acid biosynthetic process
E4N69_05580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N69_05610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N69_05620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N69_05625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N69_05630	COG0577	efflux transmembrane transporter activity
E4N69_05630	COG1136	(ABC) transporter
E4N69_05635	COG0840	transmembrane signaling receptor activity
E4N69_05640	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N69_05645	COG3876	Protein conserved in bacteria
E4N69_05655	COG2885	chlorophyll binding
E4N69_05660	COG1388	LysM domain
E4N69_05660	COG0741	lytic transglycosylase activity
E4N69_05685	COG3142	Participates in the control of copper homeostasis
E4N69_05705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N69_05710	COG0714	Associated with various cellular activities
E4N69_05725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4N69_05735	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N69_05740	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N69_05745	COG0666	response to abiotic stimulus
E4N69_05765	COG3330	Domain of unknown function (DUF4912)
E4N69_05770	COG1543	Belongs to the glycosyl hydrolase 57 family
E4N69_05775	COG0588	phosphoglycerate mutase activity
E4N69_05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N69_05805	COG1131	(ABC) transporter
E4N69_05815	COG1086	Polysaccharide biosynthesis protein
E4N69_05825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4N69_05830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N69_05840	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N69_05850	COG0101	tRNA pseudouridine synthase activity
E4N69_05855	COG0523	cobalamin synthesis protein
E4N69_05860	COG0534	Mate efflux family protein
E4N69_05865	COG1522	sequence-specific DNA binding
E4N69_05870	COG0436	Aminotransferase
E4N69_05875	COG0561	phosphatase activity
E4N69_05885	COG4608	Belongs to the ABC transporter superfamily
E4N69_05890	COG0601	transmembrane transport
E4N69_05895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N69_05935	COG1268	BioY protein
E4N69_05940	COG1122	ATPase activity
E4N69_05955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E4N69_05965	COG0552	protein localization to endoplasmic reticulum
E4N69_05980	COG1136	(ABC) transporter
E4N69_05990	COG0142	geranyltranstransferase activity
E4N69_05995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N69_06000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N69_06080	COG1309	transcriptional regulator
E4N69_06085	COG1131	(ABC) transporter
E4N69_06270	COG1309	transcriptional regulator
E4N69_06275	COG1132	(ABC) transporter
E4N69_06280	COG1132	(ABC) transporter
E4N69_06285	COG1132	(ABC) transporter
E4N69_06290	COG1132	(ABC) transporter
E4N69_06305	COG4953	penicillin-binding protein 1C
E4N69_06320	COG0724	RNA recognition motif
E4N69_06330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N69_06340	COG1196	nuclear chromosome segregation
E4N69_06350	COG0733	neurotransmitter:sodium symporter activity
E4N69_06355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N69_06360	COG0457	Tetratricopeptide repeat
E4N69_06365	COG1704	LemA family
E4N69_06375	COG1132	(ABC) transporter
E4N69_06380	COG1132	(ABC) transporter
E4N69_06395	COG1802	Transcriptional regulator
E4N69_06400	COG0632	four-way junction helicase activity
E4N69_06405	COG1739	Uncharacterized protein family UPF0029
E4N69_06410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N69_06415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N69_06425	COG0470	DNA polymerase III
E4N69_06440	COG0305	Participates in initiation and elongation during chromosome replication
E4N69_06445	COG0359	binds to the 23S rRNA
E4N69_06450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N69_06455	COG0629	single-stranded DNA binding
E4N69_06460	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N69_06480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N69_06485	COG1104	cysteine desulfurase activity
E4N69_06505	COG2208	phosphoserine phosphatase activity
E4N69_06545	COG1230	cation diffusion facilitator family transporter
E4N69_06555	COG1321	iron dependent repressor
E4N69_06560	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N69_06565	COG1121	(ABC) transporter
E4N69_06570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N69_06575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N69_06580	COG1683	Conserved Protein
E4N69_06590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N69_06600	COG3829	transcription factor binding
E4N69_06600	COG3290	protein histidine kinase activity
E4N69_06625	COG3852	Histidine kinase
E4N69_06630	COG2204	response regulator
E4N69_06635	COG0823	Involved in the tonB-independent uptake of proteins
E4N69_06655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N69_06685	COG0149	triose-phosphate isomerase activity
E4N69_06690	COG1760	l-serine dehydratase
E4N69_06695	COG1760	l-serine dehydratase
E4N69_06715	COG3956	TIGRFAM MazG family protein
E4N69_06720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N69_06725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N69_06730	COG2604	Protein of unknown function DUF115
E4N69_06740	COG0405	Gamma-glutamyltransferase
E4N69_06760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4N69_06775	COG1070	Carbohydrate kinase
E4N69_06795	COG2388	GCN5-related N-acetyl-transferase
E4N69_06820	COG0482	sulfurtransferase activity
E4N69_06845	COG0504	CTP synthase activity
E4N69_06850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N69_06850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N69_06850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N69_06880	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E4N69_06890	COG1487	ribonuclease activity
E4N69_06915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4N69_06925	COG0569	domain protein
E4N69_06930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4N69_06945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N69_06950	COG1067	ATP-dependent peptidase activity
E4N69_07025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N69_07045	COG3177	Filamentation induced by cAMP protein fic
E4N69_07050	COG1129	ABC transporter
E4N69_07065	COG1309	transcriptional regulator
E4N69_07110	COG1309	transcriptional regulator
E4N69_07125	COG0750	zinc metalloprotease
E4N69_07130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N69_07135	COG0575	Belongs to the CDS family
E4N69_07140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N69_07145	COG0233	cytoplasmic translational termination
E4N69_07150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N69_07155	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N69_07160	COG0424	maF-like protein
E4N69_07170	COG0442	prolyl-tRNA aminoacylation
E4N69_07185	COG5341	Protein conserved in bacteria
E4N69_07190	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N69_07195	COG0835	chemotaxis
E4N69_07200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N69_07205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N69_07210	COG0497	DNA recombination
E4N69_07260	COG0427	acetyl-CoA hydrolase
E4N69_07265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N69_07270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N69_07295	COG1454	alcohol dehydrogenase
E4N69_07310	COG1234	tRNA 3'-trailer cleavage
E4N69_07320	COG4254	PFAM FecR protein
E4N69_07330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N69_07335	COG0154	amidase activity
E4N69_07340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N69_07350	COG2211	Major facilitator Superfamily
E4N69_07385	COG3681	Belongs to the UPF0597 family
E4N69_07390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N69_07405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N69_07425	COG1136	(ABC) transporter
E4N69_07430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N69_07435	COG0193	aminoacyl-tRNA hydrolase activity
E4N69_07450	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N69_07460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N69_07465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N69_07495	COG2226	methyltransferase
E4N69_07500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N69_07515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N69_07520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N69_07525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N69_07540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N69_07555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N69_07570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N69_07575	COG0519	Catalyzes the synthesis of GMP from XMP
E4N69_07600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N69_07610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N69_07615	COG2885	chlorophyll binding
E4N69_07685	COG2373	Large extracellular alpha-helical protein
E4N69_07695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N69_07700	COG0785	Cytochrome C biogenesis protein
E4N69_07715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N69_07720	COG2161	toxin-antitoxin pair type II binding
E4N69_07735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N69_07745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N69_07745	COG1747	RNA polymerase binding
E4N69_07755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N69_07775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N69_07780	COG0297	glycogen (starch) synthase activity
E4N69_07790	COG0791	NLP P60 protein
E4N69_07795	COG0318	PFAM AMP-dependent synthetase and ligase
E4N69_07800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4N69_07825	COG4209	transmembrane transport
E4N69_07830	COG0395	ABC-type sugar transport system, permease component
E4N69_07860	COG0228	four-way junction DNA binding
E4N69_07865	COG1837	Belongs to the UPF0109 family
E4N69_07870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N69_07875	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N69_07880	COG0335	large ribosomal subunit rRNA binding
E4N69_07915	COG0495	leucyl-tRNA aminoacylation
E4N69_07925	COG1773	rubredoxin
E4N69_07945	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N69_07965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N69_07975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N69_07995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N69_08010	COG2375	cellular response to nickel ion
E4N69_08010	COG1132	(ABC) transporter
E4N69_08135	COG4988	ABC transporter
E4N69_08140	COG1132	(ABC) transporter
E4N69_08165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N69_08175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4N69_08180	COG0285	dihydrofolate synthase activity
E4N69_08230	COG0330	HflC and HflK could
E4N69_08235	COG0330	HflC and HflK could
E4N69_08240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4N69_08255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N69_08270	COG0455	bacterial-type flagellum organization
E4N69_08280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N69_08290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N69_08320	COG0302	gtp cyclohydrolase
E4N69_08320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4N69_08325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N69_08330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N69_08345	COG0564	pseudouridine synthase activity
E4N69_08355	COG3735	TraB family
E4N69_08360	COG2001	Belongs to the MraZ family
E4N69_08365	COG0275	rRNA processing
E4N69_08375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N69_08380	COG0772	Belongs to the SEDS family
E4N69_08385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4N69_08395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N69_08405	COG1301	dicarboxylic acid transport
E4N69_08415	COG1136	(ABC) transporter
E4N69_08430	COG0577	efflux transmembrane transporter activity
E4N69_08430	COG1136	(ABC) transporter
E4N69_08445	COG0534	Mate efflux family protein
E4N69_08450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N69_08460	COG1309	transcriptional regulator
E4N69_08465	COG1620	l-lactate permease
E4N69_08470	COG4166	transmembrane transport
E4N69_08480	COG0395	ABC-type sugar transport system, permease component
E4N69_08485	COG1175	transmembrane transport
E4N69_08490	COG1653	transport
E4N69_08520	COG2971	BadF BadG BcrA BcrD
E4N69_08535	COG2233	PERMEase
E4N69_08555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N69_08565	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4N69_08580	COG0732	type I restriction modification DNA specificity domain
E4N69_08600	COG4974	Belongs to the 'phage' integrase family
E4N69_08610	COG0732	type I restriction modification DNA specificity domain
E4N69_08620	COG0210	DNA helicase
E4N69_08645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E4N69_08660	COG1653	transport
E4N69_08690	COG0116	Belongs to the methyltransferase superfamily
E4N69_08690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4N69_08695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N69_08700	COG1413	lyase activity
E4N69_08715	COG1482	cell wall glycoprotein biosynthetic process
E4N69_08720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N69_08725	COG1573	uracil-dna glycosylase
E4N69_08745	COG1131	(ABC) transporter
E4N69_08750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N69_08755	COG0563	adenylate kinase activity
E4N69_08765	COG0772	Belongs to the SEDS family
E4N69_08770	COG0768	penicillin binding
E4N69_08785	COG1077	Cell shape determining protein MreB Mrl
E4N69_08805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N69_08810	COG0358	DNA primase activity
E4N69_08815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N69_08835	COG3189	MarR family transcriptional regulator
E4N69_08875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N69_08875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N69_08880	COG3118	belongs to the thioredoxin family
E4N69_08885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N69_08905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N69_08925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N69_08930	COG0484	heat shock protein binding
E4N69_08935	COG0528	UMP kinase activity
E4N69_08940	COG1305	Transglutaminase-like
E4N69_08955	COG0215	cysteine-tRNA ligase activity
E4N69_08960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N69_08965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N69_08980	COG2201	protein-glutamate methylesterase activity
E4N69_09020	COG0126	phosphoglycerate kinase activity
E4N69_09030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N69_09055	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4N69_09070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N69_09070	COG0574	Belongs to the PEP-utilizing enzyme family
E4N69_09075	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N69_09080	COG0318	PFAM AMP-dependent synthetase and ligase
E4N69_09090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N69_09120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N69_09125	COG1480	7TM receptor with intracellular HD hydrolase
E4N69_09145	COG0494	nUDIX hydrolase
E4N69_09150	COG0840	transmembrane signaling receptor activity
E4N69_09165	COG0735	belongs to the Fur family
E4N69_09175	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N69_09180	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N69_09185	COG1924	4 iron, 4 sulfur cluster binding
E4N69_09190	COG0786	glutamate:sodium symporter activity
E4N69_09195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4N69_09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4N69_09205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4N69_09210	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4N69_09225	COG0786	glutamate:sodium symporter activity
E4N69_09230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N69_09235	COG0840	transmembrane signaling receptor activity
E4N69_09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N69_09255	COG0457	Tetratricopeptide repeat
E4N69_09260	COG0037	tRNA processing
E4N69_09265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N69_09275	COG2088	sporulation resulting in formation of a cellular spore
E4N69_09285	COG0537	adenosine 5'-monophosphoramidase activity
E4N69_09295	COG0737	Belongs to the 5'-nucleotidase family
E4N69_09315	COG0514	ATP-dependent DNA helicase (RecQ)
E4N69_09325	COG0840	transmembrane signaling receptor activity
E4N69_09330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N69_09345	COG1309	transcriptional regulator
E4N69_09350	COG2375	cellular response to nickel ion
E4N69_09350	COG1132	(ABC) transporter
E4N69_09355	COG1132	(ABC) transporter
E4N69_09360	COG1129	ABC transporter
E4N69_09365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4N69_09375	COG2226	methyltransferase
E4N69_09385	COG0534	Mate efflux family protein
E4N69_09390	COG1309	transcriptional regulator
E4N69_09405	COG4115	mRNA cleavage
E4N69_09410	COG0488	(ABC) transporter
E4N69_09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N69_09445	COG0049	tRNA binding
E4N69_09460	COG0085	RNA polymerase activity
E4N69_09465	COG0222	ribosome binding
E4N69_09470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N69_09475	COG0081	regulation of translation
E4N69_09480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N69_09485	COG0250	Participates in transcription elongation, termination and antitermination
E4N69_09490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N69_09500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N69_09515	COG1438	arginine binding
E4N69_09520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N69_09525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N69_09545	COG0301	tRNA thio-modification
E4N69_09555	COG2502	aspartate--ammonia ligase
E4N69_09585	COG0739	heme binding
E4N69_09600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N69_09610	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N69_09615	COG2911	Protein conserved in bacteria
E4N69_09620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N69_09630	COG0739	heme binding
E4N69_09645	COG1774	PSP1 C-terminal conserved region
E4N69_09665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N69_09670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N69_09675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N69_09685	COG0427	acetyl-CoA hydrolase
E4N69_09690	COG1024	Enoyl-CoA hydratase
E4N69_09695	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4N69_09700	COG1309	transcriptional regulator
E4N69_09705	COG0574	Belongs to the PEP-utilizing enzyme family
E4N69_09705	COG3848	Pyruvate phosphate dikinase
E4N69_09715	COG0668	transmembrane transport
E4N69_09720	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N69_09725	COG3842	ATPase activity
E4N69_09735	COG1737	Transcriptional regulator
E4N69_09740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4N69_09745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N69_09750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N69_09755	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N69_09760	COG0167	dihydroorotate dehydrogenase activity
E4N69_09765	COG0543	2 iron, 2 sulfur cluster binding
E4N69_09770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N69_09775	COG0540	Belongs to the ATCase OTCase family
E4N69_09795	COG1132	(ABC) transporter
E4N69_09795	COG2375	cellular response to nickel ion
E4N69_09800	COG0500	methyltransferase
E4N69_09810	COG1132	(ABC) transporter
E4N69_09815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N69_09820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N69_09855	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N69_09860	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N69_09865	COG3845	ABC transporter
E4N69_09870	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N69_09875	COG0840	transmembrane signaling receptor activity
E4N69_09880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4N69_09910	COG0709	Synthesizes selenophosphate from selenide and ATP
E4N69_09915	COG0556	nucleotide-excision repair
E4N69_09920	COG0740	serine-type endopeptidase activity
E4N69_09950	COG0681	Belongs to the peptidase S26 family
E4N69_09955	COG0840	transmembrane signaling receptor activity
E4N69_09990	COG0300	oxidoreductase activity
E4N69_10000	COG4978	Transcriptional regulator
E4N69_10000	COG0789	Transcriptional regulator
E4N69_10005	COG1288	antiporter activity
E4N69_10015	COG1288	antiporter activity
E4N69_10020	COG2887	Belongs to the helicase family. UvrD subfamily
E4N69_10060	COG1960	acyl-CoA dehydrogenase activity
E4N69_10065	COG1012	belongs to the aldehyde dehydrogenase family
E4N69_10075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N69_10090	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N69_10120	COG2770	Histidine kinase
E4N69_10120	COG3437	response regulator, receiver
E4N69_10125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N69_10130	COG0802	atpase or kinase
E4N69_10135	COG0564	pseudouridine synthase activity
E4N69_10145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N69_10160	COG0297	glycogen (starch) synthase activity
E4N69_10180	COG1966	Carbon starvation protein
E4N69_10185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N69_10190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N69_10195	COG1957	nucleoside hydrolase
E4N69_10200	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N69_10210	COG3845	ABC transporter
E4N69_10215	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N69_10230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N69_10235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4N69_10245	COG1570	exodeoxyribonuclease VII activity
E4N69_10270	COG0719	Fe-S assembly protein
E4N69_10280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N69_10290	COG3118	belongs to the thioredoxin family
E4N69_10300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N69_10315	COG1653	transport
E4N69_10320	COG1175	transmembrane transport
E4N69_10325	COG0395	ABC-type sugar transport system, permease component
E4N69_10330	COG1027	Aspartate ammonia-lyase
E4N69_10335	COG0295	cytidine deaminase activity
E4N69_10345	COG0739	heme binding
E4N69_10375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4N69_10390	COG3876	Protein conserved in bacteria
E4N69_10395	COG2239	Acts as a magnesium transporter
E4N69_10400	COG0170	dolichyl monophosphate biosynthetic process
E4N69_10410	COG2252	PERMEase
E4N69_10420	COG1132	(ABC) transporter
E4N69_10425	COG2375	cellular response to nickel ion
E4N69_10425	COG1132	(ABC) transporter
E4N69_10435	COG1487	ribonuclease activity
E4N69_10445	COG1309	transcriptional regulator
E4N69_10450	COG0617	tRNA 3'-terminal CCA addition
E4N69_10450	COG0617	tRNA 3'-terminal CCA addition
E4N69_10500	COG0484	heat shock protein binding
E4N69_10505	COG0443	Heat shock 70 kDa protein
E4N69_10510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N69_10525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N69_10545	COG1609	Transcriptional regulator
E4N69_10570	COG3250	beta-galactosidase activity
E4N69_10580	COG0395	ABC-type sugar transport system, permease component
E4N69_10585	COG1175	transmembrane transport
E4N69_10595	COG0840	transmembrane signaling receptor activity
E4N69_10600	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N69_10610	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N69_10610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N69_10610	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N69_10610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N69_10630	COG1846	Transcriptional regulator
E4N69_10650	COG3842	ATPase activity
E4N69_10655	COG0483	inositol monophosphate 1-phosphatase activity
E4N69_10660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N69_10665	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N69_10670	COG1715	Restriction endonuclease
E4N69_10680	COG1309	transcriptional regulator
E4N69_10695	COG1129	ABC transporter
E4N69_10735	COG1846	Transcriptional regulator
E4N69_10755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N69_10775	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N69_10785	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N69_10790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N69_10795	COG1394	ATPase activity, coupled to movement of substances
E4N69_10800	COG1269	ATP hydrolysis coupled proton transport
E4N69_10820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N69_10830	COG0840	transmembrane signaling receptor activity
E4N69_10850	COG1199	ATP-dependent helicase activity
E4N69_10860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N69_10865	COG0681	Belongs to the peptidase S26 family
E4N69_10870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N69_10885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N69_10890	COG0747	negative chemotaxis
E4N69_10925	COG1733	regulation of RNA biosynthetic process
E4N69_10950	COG4115	mRNA cleavage
E4N69_10965	COG2207	Transcriptional regulator
E4N69_10965	COG3708	Transcriptional regulator
E4N69_10975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N69_10980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N69_10985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4N69_10990	COG0402	S-adenosylhomocysteine deaminase activity
E4N69_11050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N69_11055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N69_11065	COG0457	Tetratricopeptide repeat
E4N69_11070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N69_11120	COG1254	Belongs to the acylphosphatase family
E4N69_11140	COG1193	negative regulation of DNA recombination
E4N69_11155	COG0433	COG0433 Predicted ATPase
E4N69_11165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N69_11170	COG1722	exodeoxyribonuclease VII activity
E4N69_11295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4N69_11305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N69_11330	COG0793	Belongs to the peptidase S41A family
E4N69_11360	COG0203	ribosomal protein L17
E4N69_11365	COG0202	RNA polymerase activity
E4N69_11370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N69_11380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N69_11390	COG0200	Binds to the 23S rRNA
E4N69_11400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N69_11410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N69_11415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N69_11425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N69_11430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N69_11435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N69_11440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N69_11445	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N69_11455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N69_11460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N69_11470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N69_11475	COG0089	rRNA binding
E4N69_11480	COG0088	Forms part of the polypeptide exit tunnel
E4N69_11485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N69_11490	COG0051	transcription antitermination factor activity, RNA binding
E4N69_11495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N69_11510	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4N69_11515	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4N69_11520	COG4149	molybdate abc transporter
E4N69_11555	COG0741	lytic transglycosylase activity
E4N69_11560	COG1968	undecaprenyl-diphosphatase activity
E4N69_11565	COG1674	ftsk spoiiie
E4N69_11590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N69_11595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N69_11605	COG0084	hydrolase, TatD family'
E4N69_11615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N69_11690	COG0714	Associated with various cellular activities
E4N69_11700	COG0826	peptidase U32
E4N69_11710	COG0822	iron-sulfur transferase activity
E4N69_11715	COG0564	pseudouridine synthase activity
E4N69_11720	COG2255	four-way junction helicase activity
E4N69_11745	COG0445	tRNA wobble uridine modification
E4N69_11755	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N69_11770	COG1695	Transcriptional regulator
E4N69_11780	COG1983	PspC domain protein
E4N69_11830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N69_11830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N69_11830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N69_11840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N69_11845	COG1640	4-alpha-glucanotransferase
E4N69_11860	COG4452	Inner membrane protein CreD
E4N69_11865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N69_11880	COG0840	transmembrane signaling receptor activity
E4N69_11885	COG4443	Transcriptional Coactivator p15 (PC4)
E4N69_11950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N69_11960	COG0419	ATPase involved in DNA repair
E4N69_11965	COG0420	3'-5' exonuclease activity
E4N69_11970	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N69_11985	COG0728	peptidoglycan biosynthetic process
E4N69_11995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N69_12010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N69_12025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N69_12025	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N69_12030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N69_12035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N69_12055	COG1151	hydroxylamine reductase activity
E4N69_12075	COG0280	phosphate acetyltransferase
E4N69_12080	COG0492	ferredoxin-NADP+ reductase activity
E4N69_12085	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N69_12090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N69_12100	COG0237	dephospho-CoA kinase activity
E4N69_12110	COG0739	heme binding
E4N69_12120	COG1114	Component of the transport system for branched-chain amino acids
E4N69_12125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N69_12135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N69_12165	COG1177	transmembrane transport
E4N69_12205	COG0811	peptide transport
E4N69_12210	COG0848	biopolymer transport protein
E4N69_12220	COG4206	TonB-dependent receptor
E4N69_12240	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4N69_12245	COG3842	ATPase activity
E4N69_12250	COG0116	Belongs to the methyltransferase superfamily
E4N69_12255	COG0701	Predicted permease
E4N69_12320	COG0012	GTP binding
E4N69_12325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N69_12335	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N69_12340	COG0019	diaminopimelate decarboxylase activity
E4N69_12345	COG0716	FMN binding
E4N69_12355	COG1956	GAF domain-containing protein
E4N69_12365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N69_12370	COG1136	(ABC) transporter
E4N69_12375	COG0577	efflux transmembrane transporter activity
E4N69_12375	COG1136	(ABC) transporter
E4N69_12380	COG1136	(ABC) transporter
E4N69_12380	COG0577	efflux transmembrane transporter activity
E4N69_12385	COG0840	transmembrane signaling receptor activity
E4N69_12390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N69_12395	COG0423	glycine-tRNA ligase activity
E4N69_12405	COG0584	glycerophosphoryl diester phosphodiesterase
E4N69_12410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N69_12410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N69_12420	COG0205	6-phosphofructokinase activity
E4N69_12425	COG0517	IMP dehydrogenase activity
E4N69_12425	COG0516	GMP reductase activity
E4N69_12435	COG1028	Short-chain dehydrogenase reductase Sdr
E4N69_12440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N69_12445	COG2204	response regulator
E4N69_12455	COG3177	Filamentation induced by cAMP protein fic
E4N69_12490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N69_12515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N69_12535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N69_12555	COG1686	Belongs to the peptidase S11 family
E4N69_12560	COG0739	heme binding
E4N69_12565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N69_12570	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N69_12580	COG2378	regulation of single-species biofilm formation
E4N69_12620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N69_12635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N69_12640	COG0592	DNA-directed DNA polymerase activity
E4N69_12645	COG2089	acid synthase
E4N69_12660	COG4750	Nucleotidyl transferase
E4N69_12665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N69_12670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities