locus-tag	class	description
Tresu_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tresu_0002	COG0592	DNA-directed DNA polymerase activity
Tresu_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tresu_0005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tresu_0006	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tresu_0007	COG0706	membrane insertase activity
Tresu_0008	COG1847	R3H domain protein
Tresu_0010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tresu_0013	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tresu_0014	COG0295	cytidine deaminase activity
Tresu_0015	COG1534	Rna-binding protein
Tresu_0019	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tresu_0022	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
Tresu_0025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tresu_0025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tresu_0027	COG1346	cytolysis
Tresu_0028	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tresu_0029	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tresu_0031	COG0534	Mate efflux family protein
Tresu_0032	COG2885	chlorophyll binding
Tresu_0033	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tresu_0034	COG0583	DNA-binding transcription factor activity
Tresu_0038	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tresu_0039	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tresu_0041	COG1253	flavin adenine dinucleotide binding
Tresu_0042	COG4536	flavin adenine dinucleotide binding
Tresu_0044	COG0564	pseudouridine synthase activity
Tresu_0045	COG1120	ATPase activity
Tresu_0046	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tresu_0052	COG0395	ABC-type sugar transport system, permease component
Tresu_0053	COG3507	Belongs to the glycosyl hydrolase 43 family
Tresu_0055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tresu_0056	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tresu_0059	COG0501	Belongs to the peptidase M48B family
Tresu_0060	COG0357	Ribosomal RNA small subunit methyltransferase G
Tresu_0063	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tresu_0064	COG3409	Peptidoglycan-binding domain 1 protein
Tresu_0064	COG0793	Belongs to the peptidase S41A family
Tresu_0065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tresu_0068	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Tresu_0070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tresu_0071	COG0242	peptide deformylase activity
Tresu_0072	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tresu_0074	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tresu_0080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tresu_0081	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tresu_0083	COG1268	BioY protein
Tresu_0086	COG0583	DNA-binding transcription factor activity
Tresu_0092	COG0697	spore germination
Tresu_0093	COG0493	'glutamate synthase
Tresu_0097	COG1285	pathogenesis
Tresu_0101	COG0433	COG0433 Predicted ATPase
Tresu_0102	COG0534	Mate efflux family protein
Tresu_0106	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0111	COG5433	transposase activity
Tresu_0118	COG0488	(ABC) transporter
Tresu_0123	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tresu_0123	COG0574	Belongs to the PEP-utilizing enzyme family
Tresu_0124	COG3800	Transcriptional regulator
Tresu_0124	COG1396	sequence-specific DNA binding
Tresu_0129	COG0071	Belongs to the small heat shock protein (HSP20) family
Tresu_0131	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tresu_0132	COG0367	asparagine synthase
Tresu_0134	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tresu_0136	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tresu_0138	COG0601	transmembrane transport
Tresu_0140	COG0444	Belongs to the ABC transporter superfamily
Tresu_0141	COG4608	Belongs to the ABC transporter superfamily
Tresu_0143	COG1328	CTP reductase activity
Tresu_0143	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tresu_0144	COG0602	queuosine metabolic process
Tresu_0145	COG0745	RESPONSE REGULATOR receiver
Tresu_0145	COG2205	protein histidine kinase activity
Tresu_0145	COG4191	Histidine kinase
Tresu_0151	COG0571	ribonuclease III activity
Tresu_0159	COG0318	PFAM AMP-dependent synthetase and ligase
Tresu_0160	COG0459	protein refolding
Tresu_0163	COG0708	Exodeoxyribonuclease III
Tresu_0166	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tresu_0169	COG2195	Cleaves the N-terminal amino acid of tripeptides
Tresu_0170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tresu_0171	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tresu_0173	COG0791	NLP P60 protein
Tresu_0174	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Tresu_0182	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tresu_0183	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tresu_0186	COG0587	DNA-directed DNA polymerase activity
Tresu_0187	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tresu_0189	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tresu_0190	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tresu_0192	COG2183	response to ionizing radiation
Tresu_0200	COG3177	Filamentation induced by cAMP protein fic
Tresu_0201	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tresu_0204	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Tresu_0212	COG1442	glycosyl transferase family 8
Tresu_0212	COG1216	Glycosyl transferase, family 2
Tresu_0213	COG0004	ammonium transporteR
Tresu_0216	COG1373	ATPase (AAA superfamily
Tresu_0218	COG3550	peptidyl-serine autophosphorylation
Tresu_0219	COG1396	sequence-specific DNA binding
Tresu_0221	COG2972	Histidine kinase
Tresu_0222	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tresu_0222	COG2207	Transcriptional regulator
Tresu_0223	COG4213	ABC transporter substrate-binding protein
Tresu_0224	COG0714	Associated with various cellular activities
Tresu_0231	COG0484	heat shock protein binding
Tresu_0232	COG0328	RNA-DNA hybrid ribonuclease activity
Tresu_0234	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tresu_0238	COG0826	peptidase U32
Tresu_0248	COG4942	peptidase
Tresu_0256	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Tresu_0258	COG0019	diaminopimelate decarboxylase activity
Tresu_0260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tresu_0261	COG0072	phenylalanine-tRNA ligase activity
Tresu_0287	COG0629	single-stranded DNA binding
Tresu_0292	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tresu_0296	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tresu_0298	COG1477	protein flavinylation
Tresu_0299	COG0733	neurotransmitter:sodium symporter activity
Tresu_0318	COG3443	Belongs to the bacterial solute-binding protein 9 family
Tresu_0318	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tresu_0319	COG1876	peptidase activity
Tresu_0320	COG1121	(ABC) transporter
Tresu_0338	COG0493	'glutamate synthase
Tresu_0339	COG0070	glutamate synthase
Tresu_0339	COG0067	glutamate synthase
Tresu_0339	COG0069	glutamate synthase activity
Tresu_0342	COG0205	6-phosphofructokinase activity
Tresu_0345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tresu_0350	COG0442	prolyl-tRNA aminoacylation
Tresu_0351	COG1516	flagellar protein fliS
Tresu_0357	COG1739	Uncharacterized protein family UPF0029
Tresu_0359	COG0482	sulfurtransferase activity
Tresu_0367	COG0423	glycine-tRNA ligase activity
Tresu_0368	COG0656	L-ascorbic acid biosynthetic process
Tresu_0372	COG2604	Protein of unknown function DUF115
Tresu_0373	COG0768	penicillin binding
Tresu_0375	COG0739	heme binding
Tresu_0378	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tresu_0381	COG0440	acetolactate synthase activity
Tresu_0382	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tresu_0386	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tresu_0388	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tresu_0389	COG2197	response regulator
Tresu_0390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tresu_0391	COG1686	Belongs to the peptidase S11 family
Tresu_0392	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tresu_0394	COG0024	Methionine aminopeptidase
Tresu_0397	COG0154	amidase activity
Tresu_0398	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tresu_0402	COG1472	Belongs to the glycosyl hydrolase 3 family
Tresu_0403	COG2207	Transcriptional regulator
Tresu_0404	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_0404	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tresu_0404	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Tresu_0406	COG1028	Short-chain dehydrogenase reductase Sdr
Tresu_0407	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tresu_0410	COG0105	UTP biosynthetic process
Tresu_0411	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tresu_0412	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tresu_0418	COG0436	Aminotransferase
Tresu_0419	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tresu_0421	COG1523	belongs to the glycosyl hydrolase 13 family
Tresu_0428	COG5433	transposase activity
Tresu_0433	COG0326	Molecular chaperone. Has ATPase activity
Tresu_0434	COG2357	RelA SpoT domain protein
Tresu_0436	COG0165	Argininosuccinate lyase
Tresu_0437	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tresu_0438	COG0765	amino acid transport
Tresu_0440	COG0517	IMP dehydrogenase activity
Tresu_0440	COG1227	inorganic diphosphatase activity
Tresu_0447	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tresu_0447	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tresu_0447	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tresu_0450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tresu_0451	COG4656	Part of a membrane complex involved in electron transport
Tresu_0452	COG4658	electron transport chain
Tresu_0454	COG4660	Part of a membrane complex involved in electron transport
Tresu_0455	COG4657	Part of a membrane complex involved in electron transport
Tresu_0458	COG1757	Na H antiporter
Tresu_0459	COG2233	PERMEase
Tresu_0460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tresu_0461	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tresu_0462	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Tresu_0463	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tresu_0465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tresu_0466	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tresu_0467	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tresu_0469	COG0587	DNA-directed DNA polymerase activity
Tresu_0472	COG2801	Transposase and inactivated derivatives
Tresu_0472	COG3415	Transposase
Tresu_0477	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tresu_0478	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tresu_0479	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tresu_0482	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tresu_0484	COG1640	4-alpha-glucanotransferase
Tresu_0486	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tresu_0488	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tresu_0491	COG0720	synthase
Tresu_0494	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tresu_0498	COG1396	sequence-specific DNA binding
Tresu_0503	COG0811	peptide transport
Tresu_0504	COG0848	biopolymer transport protein
Tresu_0523	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tresu_0524	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Tresu_0525	COG0840	transmembrane signaling receptor activity
Tresu_0531	COG1401	restriction endodeoxyribonuclease activity
Tresu_0536	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tresu_0546	COG1373	ATPase (AAA superfamily
Tresu_0549	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tresu_0550	COG3475	LICD family
Tresu_0554	COG1373	ATPase (AAA superfamily
Tresu_0557	COG1216	Glycosyl transferase, family 2
Tresu_0557	COG1442	glycosyl transferase family 8
Tresu_0575	COG1373	ATPase (AAA superfamily
Tresu_0578	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tresu_0579	COG2239	Acts as a magnesium transporter
Tresu_0589	COG0732	type I restriction modification DNA specificity domain
Tresu_0594	COG0534	Mate efflux family protein
Tresu_0595	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tresu_0598	COG1309	transcriptional regulator
Tresu_0602	COG0495	leucyl-tRNA aminoacylation
Tresu_0603	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Tresu_0607	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tresu_0608	COG0018	arginyl-trna synthetase
Tresu_0609	COG0372	Belongs to the citrate synthase family
Tresu_0610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tresu_0611	COG0443	Heat shock 70 kDa protein
Tresu_0612	COG0484	heat shock protein binding
Tresu_0616	COG1876	peptidase activity
Tresu_0621	COG3833	ABC-type maltose transport systems, permease component
Tresu_0622	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tresu_0623	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tresu_0624	COG0724	RNA recognition motif
Tresu_0626	COG0740	serine-type endopeptidase activity
Tresu_0627	COG3956	TIGRFAM MazG family protein
Tresu_0628	COG0193	aminoacyl-tRNA hydrolase activity
Tresu_0629	COG2207	Transcriptional regulator
Tresu_0631	COG0523	cobalamin synthesis protein
Tresu_0634	COG1074	ATP-dependent DNA helicase activity
Tresu_0638	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Tresu_0639	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tresu_0643	COG3620	sequence-specific DNA binding
Tresu_0647	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0671	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tresu_0673	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0688	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tresu_0693	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0705	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0715	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0740	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0747	COG2337	Toxic component of a toxin-antitoxin (TA) module
Tresu_0778	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0785	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
Tresu_0789	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0800	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tresu_0807	COG0352	thiamine-phosphate diphosphorylase activity
Tresu_0807	COG0351	phosphomethylpyrimidine kinase
Tresu_0808	COG0352	thiamine-phosphate diphosphorylase activity
Tresu_0809	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Tresu_0812	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Tresu_0818	COG1472	Belongs to the glycosyl hydrolase 3 family
Tresu_0821	COG0445	tRNA wobble uridine modification
Tresu_0823	COG0006	proline dipeptidase activity
Tresu_0824	COG0728	peptidoglycan biosynthetic process
Tresu_0827	COG1187	pseudouridine synthase activity
Tresu_0828	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tresu_0830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tresu_0831	COG0473	3-isopropylmalate dehydrogenase activity
Tresu_0832	COG2205	protein histidine kinase activity
Tresu_0832	COG2198	Histidine kinase
Tresu_0832	COG0784	Response regulator, receiver
Tresu_0834	COG2703	oxygen carrier activity
Tresu_0839	COG1115	amino acid carrier protein
Tresu_0844	COG0058	SHG alpha-glucan phosphorylase activity
Tresu_0847	COG0322	excinuclease ABC activity
Tresu_0850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tresu_0851	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tresu_0867	COG1744	ABC transporter substrate-binding protein PnrA-like
Tresu_0868	COG2801	Transposase and inactivated derivatives
Tresu_0868	COG3415	Transposase
Tresu_0880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tresu_0881	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Tresu_0882	COG1360	Flagellar Motor Protein
Tresu_0883	COG0840	transmembrane signaling receptor activity
Tresu_0883	COG3290	protein histidine kinase activity
Tresu_0884	COG3630	sodium ion export across plasma membrane
Tresu_0889	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_0891	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tresu_0892	COG2868	ribosomal protein
Tresu_0893	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tresu_0894	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tresu_0895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tresu_0898	COG0799	negative regulation of ribosome biogenesis
Tresu_0899	COG1388	LysM domain
Tresu_0899	COG0741	lytic transglycosylase activity
Tresu_0903	COG1862	Preprotein translocase
Tresu_0904	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tresu_0905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tresu_0906	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tresu_0911	COG0488	(ABC) transporter
Tresu_0912	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tresu_0913	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tresu_0919	COG0745	RESPONSE REGULATOR receiver
Tresu_0920	COG5433	transposase activity
Tresu_0921	COG1222	aaa ATPase
Tresu_0926	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tresu_0936	COG1528	Iron-storage protein
Tresu_0950	COG0438	transferase activity, transferring glycosyl groups
Tresu_0960	COG1028	Short-chain dehydrogenase reductase Sdr
Tresu_0963	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tresu_0964	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tresu_0965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tresu_0968	COG0137	argininosuccinate synthase activity
Tresu_0969	COG0149	triose-phosphate isomerase activity
Tresu_0970	COG2059	Chromate
Tresu_0973	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tresu_0974	COG2890	protein-(glutamine-N5) methyltransferase activity
Tresu_0978	COG1121	(ABC) transporter
Tresu_0979	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tresu_0980	COG0546	phosphoglycolate phosphatase activity
Tresu_0981	COG1193	negative regulation of DNA recombination
Tresu_0982	COG1438	arginine binding
Tresu_0984	COG0166	Belongs to the GPI family
Tresu_0985	COG0084	hydrolase, TatD family'
Tresu_0988	COG0792	nuclease activity
Tresu_0991	COG0335	large ribosomal subunit rRNA binding
Tresu_0992	COG0336	Belongs to the RNA methyltransferase TrmD family
Tresu_0993	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tresu_0994	COG1837	Belongs to the UPF0109 family
Tresu_0997	COG1418	mRNA catabolic process
Tresu_1000	COG1696	Membrane protein involved in D-alanine export
Tresu_1002	COG0019	diaminopimelate decarboxylase activity
Tresu_1004	COG1216	Glycosyl transferase, family 2
Tresu_1004	COG0463	Glycosyl transferase, family 2
Tresu_1012	COG0463	Glycosyl transferase, family 2
Tresu_1032	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Tresu_1033	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tresu_1042	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Tresu_1043	COG0300	oxidoreductase activity
Tresu_1044	COG1472	Belongs to the glycosyl hydrolase 3 family
Tresu_1045	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Tresu_1045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tresu_1047	COG1671	Belongs to the UPF0178 family
Tresu_1048	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Tresu_1050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tresu_1051	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tresu_1052	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tresu_1054	COG0191	fructose-bisphosphate aldolase activity
Tresu_1058	COG0632	four-way junction helicase activity
Tresu_1059	COG2255	four-way junction helicase activity
Tresu_1060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tresu_1064	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tresu_1065	COG1086	Polysaccharide biosynthesis protein
Tresu_1066	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tresu_1068	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tresu_1069	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tresu_1070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tresu_1071	COG3063	Type IV pilus biogenesis stability protein PilW
Tresu_1073	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Tresu_1077	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tresu_1078	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tresu_1079	COG0739	heme binding
Tresu_1080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tresu_1080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tresu_1081	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Tresu_1086	COG5433	transposase activity
Tresu_1101	COG1322	Protein conserved in bacteria
Tresu_1110	COG4974	Belongs to the 'phage' integrase family
Tresu_1113	COG0732	type I restriction modification DNA specificity domain
Tresu_1114	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tresu_1121	COG1677	Flagellar hook-basal body complex protein FliE
Tresu_1122	COG1766	The M ring may be actively involved in energy transduction
Tresu_1124	COG1317	bacterial-type flagellum organization
Tresu_1125	COG1157	protein secretion by the type III secretion system
Tresu_1128	COG1475	DNA binding
Tresu_1131	COG0307	riboflavin synthase, alpha
Tresu_1132	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tresu_1132	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tresu_1134	COG0124	histidyl-tRNA synthetase
Tresu_1135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tresu_1136	COG2089	acid synthase
Tresu_1137	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tresu_1147	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tresu_1149	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tresu_1150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tresu_1151	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tresu_1154	COG0736	holo-[acyl-carrier-protein] synthase activity
Tresu_1156	COG0101	tRNA pseudouridine synthase activity
Tresu_1160	COG0494	nUDIX hydrolase
Tresu_1164	COG1366	Belongs to the anti-sigma-factor antagonist family
Tresu_1171	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tresu_1172	COG1722	exodeoxyribonuclease VII activity
Tresu_1173	COG1570	exodeoxyribonuclease VII activity
Tresu_1174	COG0731	radical SAM domain protein
Tresu_1176	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Tresu_1177	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tresu_1178	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tresu_1183	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tresu_1189	COG1773	rubredoxin
Tresu_1189	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tresu_1200	COG0488	(ABC) transporter
Tresu_1202	COG0750	zinc metalloprotease
Tresu_1203	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tresu_1204	COG0575	Belongs to the CDS family
Tresu_1205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tresu_1206	COG0233	cytoplasmic translational termination
Tresu_1207	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tresu_1208	COG0052	Belongs to the universal ribosomal protein uS2 family
Tresu_1209	COG0424	maF-like protein
Tresu_1210	COG1413	lyase activity
Tresu_1212	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tresu_1213	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tresu_1214	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tresu_1215	COG0571	ribonuclease III activity
Tresu_1221	COG0297	glycogen (starch) synthase activity
Tresu_1224	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tresu_1226	COG0254	rRNA binding
Tresu_1234	COG0776	regulation of translation
Tresu_1235	COG0360	Binds together with S18 to 16S ribosomal RNA
Tresu_1236	COG0629	single-stranded DNA binding
Tresu_1237	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tresu_1238	COG0359	binds to the 23S rRNA
Tresu_1239	COG0305	Participates in initiation and elongation during chromosome replication
Tresu_1242	COG0358	DNA primase activity
Tresu_1243	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tresu_1246	COG1077	Cell shape determining protein MreB Mrl
Tresu_1249	COG0768	penicillin binding
Tresu_1250	COG0772	Belongs to the SEDS family
Tresu_1255	COG1011	Hydrolase
Tresu_1256	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tresu_1257	COG0285	dihydrofolate synthase activity
Tresu_1260	COG1131	(ABC) transporter
Tresu_1261	COG1234	tRNA 3'-trailer cleavage
Tresu_1263	COG0662	Cupin 2, conserved barrel domain protein
Tresu_1263	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Tresu_1264	COG1091	dTDP-4-dehydrorhamnose reductase activity
Tresu_1270	COG0564	pseudouridine synthase activity
Tresu_1274	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tresu_1279	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tresu_1280	COG1102	Psort location Cytoplasmic, score
Tresu_1282	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tresu_1283	COG2115	Belongs to the xylose isomerase family
Tresu_1284	COG1070	Carbohydrate kinase
Tresu_1285	COG2207	Transcriptional regulator
Tresu_1285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tresu_1286	COG0484	heat shock protein binding
Tresu_1287	COG2204	response regulator
Tresu_1288	COG5002	protein histidine kinase activity
Tresu_1291	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tresu_1292	COG0666	response to abiotic stimulus
Tresu_1294	COG1122	ATPase activity
Tresu_1295	COG1122	ATPase activity
Tresu_1297	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tresu_1298	COG0740	serine-type endopeptidase activity
Tresu_1299	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tresu_1302	COG1196	nuclear chromosome segregation
Tresu_1304	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tresu_1306	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tresu_1307	COG0628	permease
Tresu_1310	COG0670	Belongs to the BI1 family
Tresu_1311	COG1199	ATP-dependent helicase activity
Tresu_1312	COG0039	L-malate dehydrogenase activity
Tresu_1320	COG0543	2 iron, 2 sulfur cluster binding
Tresu_1322	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tresu_1324	COG1216	Glycosyl transferase, family 2
Tresu_1331	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tresu_1331	COG0463	Glycosyl transferase, family 2
Tresu_1333	COG3475	LICD family
Tresu_1334	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tresu_1337	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tresu_1337	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tresu_1338	COG2348	transferase activity, transferring amino-acyl groups
Tresu_1348	COG0564	pseudouridine synthase activity
Tresu_1350	COG0617	tRNA 3'-terminal CCA addition
Tresu_1351	COG2267	carboxylic ester hydrolase activity
Tresu_1352	COG0180	Tryptophanyl-tRNA synthetase
Tresu_1353	COG0297	glycogen (starch) synthase activity
Tresu_1354	COG0436	Aminotransferase
Tresu_1357	COG4211	Belongs to the binding-protein-dependent transport system permease family
Tresu_1358	COG1129	ABC transporter
Tresu_1359	COG1879	ABC-type sugar transport system periplasmic component
Tresu_1361	COG3459	Glycosyltransferase 36 associated
Tresu_1363	COG0742	ribosomal rna small subunit methyltransferase
Tresu_1366	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tresu_1368	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tresu_1369	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tresu_1376	COG2252	PERMEase
Tresu_1378	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tresu_1379	COG1136	(ABC) transporter
Tresu_1381	COG3093	addiction module antidote protein HigA
Tresu_1393	COG0802	atpase or kinase
Tresu_1395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tresu_1396	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tresu_1397	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tresu_1402	COG4786	Flagellar basal body rod
Tresu_1405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tresu_1408	COG0268	Binds directly to 16S ribosomal RNA
Tresu_1411	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Tresu_1421	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tresu_1423	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tresu_1425	COG5433	transposase activity
Tresu_1426	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tresu_1427	COG0706	membrane insertase activity
Tresu_1429	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tresu_1431	COG3118	belongs to the thioredoxin family
Tresu_1432	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tresu_1434	COG1269	ATP hydrolysis coupled proton transport
Tresu_1435	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Tresu_1436	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Tresu_1438	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Tresu_1445	COG0577	efflux transmembrane transporter activity
Tresu_1446	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tresu_1447	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tresu_1450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tresu_1454	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Tresu_1465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tresu_1466	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_1466	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_1466	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tresu_1469	COG0028	Belongs to the TPP enzyme family
Tresu_1470	COG3330	Domain of unknown function (DUF4912)
Tresu_1472	COG0706	membrane insertase activity
Tresu_1474	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tresu_1482	COG0542	response to heat
Tresu_1486	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tresu_1487	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tresu_1488	COG1971	Probably functions as a manganese efflux pump
Tresu_1490	COG2502	aspartate--ammonia ligase
Tresu_1491	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Tresu_1503	COG0563	adenylate kinase activity
Tresu_1504	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tresu_1507	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tresu_1510	COG0396	ATPase activity
Tresu_1517	COG0765	amino acid transport
Tresu_1518	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tresu_1519	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tresu_1521	COG1469	GTP cyclohydrolase I activity
Tresu_1522	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tresu_1525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tresu_1526	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Tresu_1527	COG1242	4 iron, 4 sulfur cluster binding
Tresu_1532	COG1191	sigma factor activity
Tresu_1534	COG0455	bacterial-type flagellum organization
Tresu_1535	COG1419	protein localization to endoplasmic reticulum
Tresu_1537	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tresu_1538	COG1684	flagellar biosynthetic protein fliR
Tresu_1539	COG1987	bacterial-type flagellum assembly
Tresu_1540	COG1338	Plays a role in the flagellum-specific transport system
Tresu_1543	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tresu_1544	COG1580	Controls the rotational direction of flagella during chemotaxis
Tresu_1545	COG1360	Flagellar Motor Protein
Tresu_1547	COG1582	Flagellar protein (FlbD)
Tresu_1548	COG1418	mRNA catabolic process
Tresu_1549	COG0745	RESPONSE REGULATOR receiver
Tresu_1550	COG5002	protein histidine kinase activity
Tresu_1551	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tresu_1554	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tresu_1563	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Tresu_1565	COG0681	Belongs to the peptidase S26 family
Tresu_1565	COG0681	Belongs to the peptidase S26 family
Tresu_1568	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tresu_1569	COG0534	Mate efflux family protein
Tresu_1575	COG0840	transmembrane signaling receptor activity
Tresu_1577	COG0301	tRNA thio-modification
Tresu_1580	COG0438	transferase activity, transferring glycosyl groups
Tresu_1581	COG1573	uracil-dna glycosylase
Tresu_1582	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tresu_1583	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tresu_1584	COG0653	protein targeting
Tresu_1585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tresu_1586	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tresu_1587	COG4974	Belongs to the 'phage' integrase family
Tresu_1588	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tresu_1588	COG0551	DNA topoisomerase type I activity
Tresu_1589	COG0758	DNA mediated transformation
Tresu_1589	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tresu_1591	COG4974	Belongs to the 'phage' integrase family
Tresu_1595	COG0772	Belongs to the SEDS family
Tresu_1596	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Tresu_1598	COG0275	rRNA processing
Tresu_1599	COG2001	Belongs to the MraZ family
Tresu_1601	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tresu_1602	COG0217	transcriptional regulatory protein
Tresu_1604	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_1605	COG0564	pseudouridine synthase activity
Tresu_1607	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tresu_1607	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_1607	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_1611	COG2201	protein-glutamate methylesterase activity
Tresu_1613	COG0835	chemotaxis
Tresu_1614	COG0643	Histidine kinase
Tresu_1614	COG2198	Histidine kinase
Tresu_1616	COG0745	RESPONSE REGULATOR receiver
Tresu_1618	COG1394	ATPase activity, coupled to movement of substances
Tresu_1619	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Tresu_1620	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Tresu_1624	COG1269	ATP hydrolysis coupled proton transport
Tresu_1628	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tresu_1636	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tresu_1650	COG2818	Glycosylase
Tresu_1657	COG0084	hydrolase, TatD family'
Tresu_1659	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tresu_1660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Tresu_1661	COG0126	phosphoglycerate kinase activity
Tresu_1664	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tresu_1666	COG1702	phosphate starvation-inducible protein PhoH
Tresu_1668	COG0525	valine-tRNA ligase activity
Tresu_1675	COG1373	ATPase (AAA superfamily
Tresu_1676	COG4475	Protein of unknown function (DUF436)
Tresu_1677	COG1253	flavin adenine dinucleotide binding
Tresu_1688	COG2205	protein histidine kinase activity
Tresu_1689	COG0745	RESPONSE REGULATOR receiver
Tresu_1701	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Tresu_1702	COG1691	(AIR) carboxylase
Tresu_1703	COG1606	tRNA processing
Tresu_1706	COG0840	transmembrane signaling receptor activity
Tresu_1725	COG0629	single-stranded DNA binding
Tresu_1736	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tresu_1747	COG3451	type IV secretory pathway VirB4
Tresu_1750	COG4962	Type ii secretion system protein e
Tresu_1773	COG0551	DNA topoisomerase type I activity
Tresu_1773	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tresu_1775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tresu_1792	COG3250	beta-galactosidase activity
Tresu_1794	COG0724	RNA recognition motif
Tresu_1797	COG0564	pseudouridine synthase activity
Tresu_1799	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tresu_1801	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tresu_1801	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tresu_1802	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Tresu_1804	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Tresu_1805	COG2204	response regulator
Tresu_1806	COG0539	negative regulation of cytoplasmic translation
Tresu_1808	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tresu_1809	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tresu_1810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tresu_1811	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tresu_1814	COG0739	heme binding
Tresu_1820	COG0481	GTPase activity
Tresu_1821	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tresu_1823	COG0037	tRNA processing
Tresu_1824	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tresu_1826	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tresu_1831	COG0497	DNA recombination
Tresu_1832	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tresu_1833	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tresu_1834	COG0835	chemotaxis
Tresu_1835	COG1040	competence protein
Tresu_1836	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tresu_1838	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tresu_1840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tresu_1843	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tresu_1844	COG1410	methionine synthase
Tresu_1844	COG0646	methionine synthase
Tresu_1846	COG1482	cell wall glycoprotein biosynthetic process
Tresu_1848	COG0813	purine-nucleoside phosphorylase activity
Tresu_1849	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tresu_1851	COG0501	Belongs to the peptidase M48B family
Tresu_1852	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tresu_1853	COG0287	Prephenate dehydrogenase
Tresu_1854	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tresu_1857	COG0557	exoribonuclease II activity
Tresu_1860	COG0840	transmembrane signaling receptor activity
Tresu_1862	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tresu_1863	COG1104	cysteine desulfurase activity
Tresu_1865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tresu_1867	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tresu_1871	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tresu_1873	COG1747	RNA polymerase binding
Tresu_1873	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tresu_1875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tresu_1876	COG0640	Transcriptional regulator
Tresu_1880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tresu_1886	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tresu_1893	COG1051	belongs to the nudix hydrolase family
Tresu_1901	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tresu_1905	COG4783	chaperone-mediated protein folding
Tresu_1932	COG0582	viral genome integration into host DNA
Tresu_1936	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tresu_1937	COG2226	methyltransferase
Tresu_1942	COG0583	DNA-binding transcription factor activity
Tresu_1946	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tresu_1948	COG0456	acetyltransferase
Tresu_1951	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tresu_1954	COG2264	protein methyltransferase activity
Tresu_1956	COG4585	Histidine kinase
Tresu_1962	COG3041	Addiction module toxin RelE StbE family
Tresu_1980	COG3177	Filamentation induced by cAMP protein fic
Tresu_1989	COG0583	DNA-binding transcription factor activity
Tresu_1991	COG5433	transposase activity
Tresu_1995	COG5433	transposase activity
Tresu_1999	COG4585	Histidine kinase
Tresu_2002	COG1373	ATPase (AAA superfamily
Tresu_2003	COG3040	lipid binding
Tresu_2004	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Tresu_2004	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Tresu_2010	COG3250	beta-galactosidase activity
Tresu_2015	COG1122	ATPase activity
Tresu_2019	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Tresu_2020	COG0573	inorganic phosphate transmembrane transporter activity
Tresu_2021	COG0581	inorganic phosphate transmembrane transporter activity
Tresu_2022	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tresu_2023	COG0704	Plays a role in the regulation of phosphate uptake
Tresu_2026	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Tresu_2028	COG5002	protein histidine kinase activity
Tresu_2029	COG2003	Belongs to the UPF0758 family
Tresu_2030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tresu_2031	COG0556	nucleotide-excision repair
Tresu_2034	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tresu_2036	COG0321	lipoyl(octanoyl) transferase activity
Tresu_2036	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Tresu_2038	COG0017	Asparaginyl-tRNA synthetase
Tresu_2048	COG0765	amino acid transport
Tresu_2049	COG4215	(ABC) transporter
Tresu_2050	COG1126	abc transporter atp-binding protein
Tresu_2055	COG0028	Belongs to the TPP enzyme family
Tresu_2057	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tresu_2059	COG1475	DNA binding
Tresu_2060	COG1192	Involved in chromosome partitioning
Tresu_2063	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tresu_2064	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tresu_2065	COG0534	Mate efflux family protein
Tresu_2066	COG1388	LysM domain
Tresu_2066	COG3942	CHAP domain
Tresu_2067	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tresu_2070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Tresu_2073	COG1283	sodium-dependent phosphate transmembrane transporter activity
Tresu_2076	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tresu_2077	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tresu_2080	COG0514	ATP-dependent DNA helicase (RecQ)
Tresu_2082	COG0343	queuine tRNA-ribosyltransferase activity
Tresu_2085	COG0756	dUTP diphosphatase activity
Tresu_2087	COG1185	polyribonucleotide nucleotidyltransferase activity
Tresu_2088	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tresu_2089	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tresu_2090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tresu_2091	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tresu_2093	COG0779	Required for maturation of 30S ribosomal subunits
Tresu_2094	COG5433	transposase activity
Tresu_2097	COG0616	signal peptide processing
Tresu_2099	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tresu_2100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tresu_2102	COG1592	Rubrerythrin
Tresu_2104	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Tresu_2105	COG3842	ATPase activity
Tresu_2106	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tresu_2107	COG1177	transmembrane transport
Tresu_2111	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tresu_2112	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Tresu_2116	COG3977	Valine--pyruvate aminotransferase
Tresu_2117	COG0542	response to heat
Tresu_2118	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Tresu_2119	COG3880	PFAM UvrB UvrC protein
Tresu_2121	COG1136	(ABC) transporter
Tresu_2124	COG0552	protein localization to endoplasmic reticulum
Tresu_2129	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Tresu_2133	COG0659	secondary active sulfate transmembrane transporter activity
Tresu_2134	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tresu_2135	COG0012	GTP binding
Tresu_2136	COG0564	pseudouridine synthase activity
Tresu_2138	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tresu_2140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tresu_2143	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Tresu_2151	COG0516	GMP reductase activity
Tresu_2151	COG0517	IMP dehydrogenase activity
Tresu_2153	COG0534	Mate efflux family protein
Tresu_2155	COG1070	Carbohydrate kinase
Tresu_2156	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tresu_2159	COG0534	Mate efflux family protein
Tresu_2160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tresu_2163	COG0280	phosphate acetyltransferase
Tresu_2166	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Tresu_2167	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tresu_2172	COG0488	(ABC) transporter
Tresu_2176	COG5433	transposase activity
Tresu_2178	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tresu_2179	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tresu_2189	COG1337	RAMP superfamily
Tresu_2195	COG3833	ABC-type maltose transport systems, permease component
Tresu_2196	COG1175	transmembrane transport
Tresu_2197	COG2182	Extracellular solute-binding protein
Tresu_2198	COG1609	Transcriptional regulator
Tresu_2199	COG0800	Aldolase
Tresu_2202	COG1966	Carbon starvation protein
Tresu_2204	COG0205	6-phosphofructokinase activity
Tresu_2205	COG1704	LemA family
Tresu_2207	COG2201	protein-glutamate methylesterase activity
Tresu_2209	COG1196	nuclear chromosome segregation
Tresu_2209	COG0741	lytic transglycosylase activity
Tresu_2209	COG0739	heme binding
Tresu_2210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Tresu_2211	COG1022	Amp-dependent synthetase and ligase
Tresu_2213	COG0789	Transcriptional regulator
Tresu_2214	COG1160	GTP binding
Tresu_2216	COG3706	GGDEF domain
Tresu_2216	COG0745	RESPONSE REGULATOR receiver
Tresu_2219	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tresu_2219	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tresu_2222	COG1854	S-ribosylhomocysteine lyase activity
Tresu_2224	COG1362	aminopeptidase activity
Tresu_2226	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tresu_2226	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tresu_2263	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tresu_2264	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Tresu_2265	COG1937	Protein conserved in bacteria
Tresu_2267	COG2217	Heavy metal translocating P-type atpase
Tresu_2269	COG0514	ATP-dependent DNA helicase (RecQ)
Tresu_2270	COG0475	glutathione-regulated potassium exporter activity
Tresu_2273	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tresu_2281	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tresu_2282	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tresu_2283	COG0215	cysteine-tRNA ligase activity
Tresu_2287	COG0528	UMP kinase activity
Tresu_2289	COG0151	Belongs to the GarS family
Tresu_2290	COG1968	undecaprenyl-diphosphatase activity
Tresu_2291	COG0569	domain protein
Tresu_2292	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tresu_2293	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tresu_2295	COG0330	HflC and HflK could
Tresu_2296	COG0330	HflC and HflK could
Tresu_2299	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tresu_2303	COG1774	PSP1 C-terminal conserved region
Tresu_2306	COG0739	heme binding
Tresu_2307	COG0084	hydrolase, TatD family'
Tresu_2308	COG3116	cell division
Tresu_2308	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Tresu_2310	COG3706	GGDEF domain
Tresu_2310	COG5001	Diguanylate cyclase
Tresu_2310	COG4251	negative regulation of phosphorylation
Tresu_2310	COG2203	Gaf domain
Tresu_2314	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tresu_2315	COG0840	transmembrane signaling receptor activity
Tresu_2316	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tresu_2321	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tresu_2324	COG3547	Transposase (IS116 IS110 IS902 family)
Tresu_2325	COG1598	PFAM Uncharacterised protein family UPF0150
Tresu_2328	COG1373	ATPase (AAA superfamily
Tresu_2330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tresu_2331	COG2900	Belongs to the SlyX family
Tresu_2332	COG1272	protein, Hemolysin III
Tresu_2333	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tresu_2335	COG4213	ABC transporter substrate-binding protein
Tresu_2336	COG0148	phosphopyruvate hydratase activity
Tresu_2341	COG1122	ATPase activity
Tresu_2352	COG1879	ABC-type sugar transport system periplasmic component
Tresu_2354	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tresu_2355	COG1172	Belongs to the binding-protein-dependent transport system permease family
Tresu_2356	COG2207	Transcriptional regulator
Tresu_2359	COG2169	Transcriptional regulator
Tresu_2360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tresu_2361	COG0668	transmembrane transport
Tresu_2364	COG4166	transmembrane transport
Tresu_2368	COG4443	Transcriptional Coactivator p15 (PC4)
Tresu_2370	COG1652	LysM domain
Tresu_2371	COG0494	nUDIX hydrolase
Tresu_2373	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tresu_2375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tresu_2376	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tresu_2378	COG0667	Aldo Keto reductase
Tresu_2381	COG1119	ATPase activity
Tresu_2382	COG0583	DNA-binding transcription factor activity
Tresu_2384	COG5433	transposase activity
Tresu_2390	COG1137	ATPase activity
Tresu_2392	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tresu_2397	COG3012	SEC-C Motif Domain Protein
Tresu_2407	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tresu_2408	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tresu_2414	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tresu_2415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tresu_2416	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Tresu_2418	COG2201	protein-glutamate methylesterase activity
Tresu_2423	COG0517	IMP dehydrogenase activity
Tresu_2423	COG0516	GMP reductase activity
Tresu_2424	COG0410	ABC transporter
Tresu_2425	COG0411	ABC transporter
Tresu_2427	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tresu_2428	COG0683	leucine binding
Tresu_2430	COG0203	ribosomal protein L17
Tresu_2431	COG0202	RNA polymerase activity
Tresu_2432	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tresu_2433	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tresu_2434	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tresu_2436	COG0200	Binds to the 23S rRNA
Tresu_2437	COG1841	ribosomal large subunit assembly
Tresu_2438	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tresu_2439	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tresu_2441	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tresu_2442	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tresu_2443	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tresu_2444	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tresu_2445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tresu_2446	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tresu_2447	COG0255	Belongs to the universal ribosomal protein uL29 family
Tresu_2448	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tresu_2449	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tresu_2450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tresu_2451	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tresu_2452	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tresu_2453	COG0089	rRNA binding
Tresu_2454	COG0088	Forms part of the polypeptide exit tunnel
Tresu_2455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tresu_2456	COG0051	transcription antitermination factor activity, RNA binding
Tresu_2457	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tresu_2458	COG0049	tRNA binding
Tresu_2459	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tresu_2460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tresu_2461	COG0085	RNA polymerase activity
Tresu_2462	COG0222	ribosome binding
Tresu_2463	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tresu_2464	COG0081	regulation of translation
Tresu_2465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tresu_2466	COG0250	Participates in transcription elongation, termination and antitermination
Tresu_2467	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tresu_2468	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tresu_2469	COG1045	serine acetyltransferase
Tresu_2479	COG0455	bacterial-type flagellum organization
Tresu_2480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tresu_2481	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tresu_2482	COG0138	bifunctional purine biosynthesis protein purh
Tresu_2483	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tresu_2483	COG0140	phosphoribosyl-ATP diphosphatase activity
Tresu_2485	COG5001	Diguanylate cyclase
Tresu_2485	COG3300	MHYT domain
Tresu_2490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tresu_2491	COG2199	diguanylate cyclase activity
Tresu_2491	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tresu_2498	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tresu_2500	COG4120	Belongs to the binding-protein-dependent transport system permease family
Tresu_2501	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Tresu_2503	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Tresu_2507	COG0564	pseudouridine synthase activity
Tresu_2509	COG1053	succinate dehydrogenase
Tresu_2515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tresu_2516	COG0622	Phosphoesterase
Tresu_2520	COG1454	alcohol dehydrogenase
Tresu_2522	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tresu_2523	COG1674	ftsk spoiiie
Tresu_2524	COG3858	chitin binding
Tresu_2526	COG1464	Belongs to the NlpA lipoprotein family
Tresu_2528	COG0436	Aminotransferase
Tresu_2529	COG1522	sequence-specific DNA binding
Tresu_2530	COG0131	Imidazoleglycerol-phosphate dehydratase
Tresu_2531	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tresu_2532	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Tresu_2533	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tresu_2535	COG1061	Type III restriction enzyme res subunit
Tresu_2536	COG1592	Rubrerythrin
Tresu_2536	COG1773	rubredoxin
Tresu_2540	COG0116	Belongs to the methyltransferase superfamily
Tresu_2541	COG5433	transposase activity
Tresu_2549	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Tresu_2553	COG1396	sequence-specific DNA binding
Tresu_2556	COG0539	negative regulation of cytoplasmic translation
Tresu_2557	COG1051	belongs to the nudix hydrolase family
Tresu_2559	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tresu_2560	COG0187	DNA topoisomerase II activity
Tresu_2617	COG3179	chitinase
Tresu_2628	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Tresu_2629	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tresu_2653	COG5433	transposase activity
Tresu_2697	COG4962	Type ii secretion system protein e
Tresu_2701	COG3451	type IV secretory pathway VirB4
Tresu_2720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair