locus-tag	class	description
GWP43_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWP43_00015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP43_00020	COG0156	8-amino-7-oxononanoate synthase activity
GWP43_00060	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWP43_00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_00070	COG1120	ATPase activity
GWP43_00075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWP43_00095	COG0326	Molecular chaperone. Has ATPase activity
GWP43_00100	COG1162	GTPase activity
GWP43_00110	COG1132	(ABC) transporter
GWP43_00125	COG2378	regulation of single-species biofilm formation
GWP43_00130	COG1002	Type II restriction enzyme, methylase subunits
GWP43_00135	COG1002	Type II restriction enzyme, methylase subunits
GWP43_00165	COG4115	mRNA cleavage
GWP43_00170	COG1132	(ABC) transporter
GWP43_00180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP43_00225	COG2183	response to ionizing radiation
GWP43_00240	COG2949	membrane
GWP43_00275	COG0425	Belongs to the sulfur carrier protein TusA family
GWP43_00300	COG0438	transferase activity, transferring glycosyl groups
GWP43_00300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP43_00305	COG0488	(ABC) transporter
GWP43_00320	COG0840	transmembrane signaling receptor activity
GWP43_00325	COG1054	Belongs to the UPF0176 family
GWP43_00330	COG0024	Methionine aminopeptidase
GWP43_00335	COG0484	heat shock protein binding
GWP43_00355	COG0739	heme binding
GWP43_00365	COG0534	Mate efflux family protein
GWP43_00375	COG1129	ABC transporter
GWP43_00505	COG1757	Na H antiporter
GWP43_00510	COG5001	Diguanylate cyclase
GWP43_00535	COG1074	ATP-dependent DNA helicase activity
GWP43_00585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_00590	COG4977	sequence-specific DNA binding
GWP43_00590	COG1917	Cupin 2, conserved barrel domain protein
GWP43_00605	COG1129	ABC transporter
GWP43_00610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP43_00620	COG2211	Major facilitator Superfamily
GWP43_00630	COG1132	(ABC) transporter
GWP43_00635	COG1132	(ABC) transporter
GWP43_00640	COG2217	Heavy metal translocating P-type atpase
GWP43_00645	COG0640	Transcriptional regulator
GWP43_00660	COG2217	Heavy metal translocating P-type atpase
GWP43_00710	COG1191	sigma factor activity
GWP43_00730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWP43_00765	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GWP43_00770	COG0180	Tryptophanyl-tRNA synthetase
GWP43_00775	COG0670	Belongs to the BI1 family
GWP43_00790	COG2604	Protein of unknown function DUF115
GWP43_00795	COG0768	penicillin binding
GWP43_00800	COG0681	Belongs to the peptidase S26 family
GWP43_01230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP43_01240	COG0613	PHP domain protein
GWP43_01265	COG1193	negative regulation of DNA recombination
GWP43_01275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWP43_01320	COG0629	single-stranded DNA binding
GWP43_01330	COG0281	malic enzyme
GWP43_01335	COG0039	L-malate dehydrogenase activity
GWP43_01375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWP43_01385	COG0513	Belongs to the DEAD box helicase family
GWP43_01395	COG0395	ABC-type sugar transport system, permease component
GWP43_01400	COG1175	transmembrane transport
GWP43_01410	COG2011	ABC-type metal ion transport system permease component
GWP43_01420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_01435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWP43_01435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWP43_01445	COG0351	phosphomethylpyrimidine kinase
GWP43_01460	COG0037	tRNA processing
GWP43_01515	COG0840	transmembrane signaling receptor activity
GWP43_01540	COG0825	malonyl-CoA metabolic process
GWP43_01560	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWP43_01565	COG4656	Part of a membrane complex involved in electron transport
GWP43_01570	COG4658	electron transport chain
GWP43_01575	COG4659	FMN binding
GWP43_01580	COG4660	Part of a membrane complex involved in electron transport
GWP43_01585	COG4657	Part of a membrane complex involved in electron transport
GWP43_01590	COG2878	Part of a membrane complex involved in electron transport
GWP43_01595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWP43_01600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_01605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP43_01610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP43_01620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWP43_01635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWP43_01650	COG0653	protein targeting
GWP43_01660	COG0450	alkyl hydroperoxide reductase
GWP43_01670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWP43_01685	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWP43_01690	COG1671	Belongs to the UPF0178 family
GWP43_01695	COG3437	response regulator, receiver
GWP43_01700	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP43_01705	COG1115	amino acid carrier protein
GWP43_01710	COG0511	ligase activity, forming carbon-carbon bonds
GWP43_01710	COG5016	pyruvate
GWP43_01715	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_01720	COG3041	Addiction module toxin RelE StbE family
GWP43_01745	COG1131	(ABC) transporter
GWP43_01765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWP43_01800	COG4656	Part of a membrane complex involved in electron transport
GWP43_01810	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWP43_01815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP43_01840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP43_01840	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP43_01855	COG1121	(ABC) transporter
GWP43_01860	COG1639	'signal transduction protein
GWP43_01865	COG0543	2 iron, 2 sulfur cluster binding
GWP43_01880	COG0733	neurotransmitter:sodium symporter activity
GWP43_01885	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_01895	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP43_01900	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_01925	COG4536	flavin adenine dinucleotide binding
GWP43_01940	COG0542	response to heat
GWP43_01975	COG1012	belongs to the aldehyde dehydrogenase family
GWP43_01980	COG1414	Transcriptional regulator
GWP43_01990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWP43_02000	COG0513	Belongs to the DEAD box helicase family
GWP43_02005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWP43_02010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWP43_02015	COG1028	Short-chain dehydrogenase reductase Sdr
GWP43_02020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWP43_02030	COG1647	Serine aminopeptidase, S33
GWP43_02085	COG1309	transcriptional regulator
GWP43_02100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP43_02105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWP43_02105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP43_02150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWP43_02155	COG0706	membrane insertase activity
GWP43_02160	COG1847	R3H domain protein
GWP43_02175	COG1862	Preprotein translocase
GWP43_02180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP43_02185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP43_02190	COG1040	competence protein
GWP43_02200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWP43_02210	COG0058	SHG alpha-glucan phosphorylase activity
GWP43_02225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWP43_02230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_02240	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GWP43_02245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWP43_02250	COG0457	Tetratricopeptide repeat
GWP43_02255	COG0733	neurotransmitter:sodium symporter activity
GWP43_02285	COG1102	Psort location Cytoplasmic, score
GWP43_02305	COG0534	Mate efflux family protein
GWP43_02320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWP43_02360	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWP43_02365	COG0740	serine-type endopeptidase activity
GWP43_02370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWP43_02380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWP43_02400	COG0395	ABC-type sugar transport system, permease component
GWP43_02405	COG4209	transmembrane transport
GWP43_02440	COG1129	ABC transporter
GWP43_02490	COG0481	GTPase activity
GWP43_02525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP43_02530	COG0549	Belongs to the carbamate kinase family
GWP43_02535	COG1288	antiporter activity
GWP43_02540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWP43_02545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWP43_02640	COG1487	ribonuclease activity
GWP43_02680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWP43_02715	COG0747	negative chemotaxis
GWP43_02720	COG0601	transmembrane transport
GWP43_02730	COG4172	Belongs to the ABC transporter superfamily
GWP43_02745	COG1132	(ABC) transporter
GWP43_02780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP43_02785	COG1362	aminopeptidase activity
GWP43_02820	COG1373	ATPase (AAA superfamily
GWP43_02835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWP43_02870	COG1216	Glycosyl transferase, family 2
GWP43_02880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP43_02905	COG1393	Belongs to the ArsC family
GWP43_02910	COG3328	transposase activity
GWP43_02980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWP43_02985	COG1192	Involved in chromosome partitioning
GWP43_02990	COG1475	DNA binding
GWP43_03000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWP43_03005	COG1418	mRNA catabolic process
GWP43_03030	COG2161	toxin-antitoxin pair type II binding
GWP43_03070	COG3549	Plasmid maintenance system killer
GWP43_03085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWP43_03090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP43_03095	COG5001	Diguanylate cyclase
GWP43_03095	COG4251	negative regulation of phosphorylation
GWP43_03095	COG3706	GGDEF domain
GWP43_03095	COG2203	Gaf domain
GWP43_03100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_03105	COG0205	6-phosphofructokinase activity
GWP43_03110	COG0124	histidyl-tRNA synthetase
GWP43_03120	COG2204	response regulator
GWP43_03125	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWP43_03135	COG0840	transmembrane signaling receptor activity
GWP43_03185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_03200	COG4786	Flagellar basal body rod
GWP43_03210	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWP43_03225	COG1120	ATPase activity
GWP43_03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_03245	COG2226	methyltransferase
GWP43_03255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWP43_03285	COG0251	oxidation-reduction process
GWP43_03300	COG1047	Peptidyl-prolyl cis-trans
GWP43_03305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWP43_03315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWP43_03320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWP43_03330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWP43_03330	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWP43_03350	COG0779	Required for maturation of 30S ribosomal subunits
GWP43_03360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWP43_03365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP43_03375	COG0196	riboflavin kinase activity
GWP43_03390	COG0756	dUTP diphosphatase activity
GWP43_03405	COG0840	transmembrane signaling receptor activity
GWP43_03410	COG1253	flavin adenine dinucleotide binding
GWP43_03425	COG0840	transmembrane signaling receptor activity
GWP43_03435	COG0546	phosphoglycolate phosphatase activity
GWP43_03445	COG1609	Transcriptional regulator
GWP43_03475	COG0762	integral membrane protein
GWP43_03490	COG4211	Belongs to the binding-protein-dependent transport system permease family
GWP43_03495	COG1129	ABC transporter
GWP43_03510	COG1879	ABC-type sugar transport system periplasmic component
GWP43_03520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWP43_03530	COG0826	peptidase U32
GWP43_03550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_03555	COG0444	Belongs to the ABC transporter superfamily
GWP43_03560	COG4608	Belongs to the ABC transporter superfamily
GWP43_03565	COG0616	signal peptide processing
GWP43_03605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWP43_03615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWP43_03630	COG0322	excinuclease ABC activity
GWP43_03650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWP43_03680	COG4115	mRNA cleavage
GWP43_03695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_03715	COG0698	ribose 5-phosphate isomerase
GWP43_03725	COG1132	(ABC) transporter
GWP43_03725	COG2375	cellular response to nickel ion
GWP43_03730	COG1132	(ABC) transporter
GWP43_03740	COG4115	mRNA cleavage
GWP43_03755	COG1131	(ABC) transporter
GWP43_03790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWP43_03790	COG0456	acetyltransferase
GWP43_03840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWP43_03860	COG1360	Flagellar Motor Protein
GWP43_03865	COG1580	Controls the rotational direction of flagella during chemotaxis
GWP43_03870	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_03875	COG1776	CheC inhibitor of MCP methylation
GWP43_03875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_03885	COG1338	Plays a role in the flagellum-specific transport system
GWP43_03890	COG1987	bacterial-type flagellum assembly
GWP43_03895	COG1684	flagellar biosynthetic protein fliR
GWP43_03900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP43_03905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP43_03910	COG1419	protein localization to endoplasmic reticulum
GWP43_03920	COG0534	Mate efflux family protein
GWP43_03930	COG0557	exoribonuclease II activity
GWP43_03935	COG1362	aminopeptidase activity
GWP43_03945	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP43_03945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP43_03950	COG0525	valine-tRNA ligase activity
GWP43_03970	COG2604	Protein of unknown function DUF115
GWP43_03995	COG4974	Belongs to the 'phage' integrase family
GWP43_04000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWP43_04000	COG0551	DNA topoisomerase type I activity
GWP43_04005	COG0758	DNA mediated transformation
GWP43_04015	COG0475	glutathione-regulated potassium exporter activity
GWP43_04020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWP43_04025	COG0672	)-iron permease
GWP43_04030	COG3470	protein probably involved in high-affinity Fe2 transport
GWP43_04045	COG0577	efflux transmembrane transporter activity
GWP43_04045	COG1136	(ABC) transporter
GWP43_04050	COG1136	(ABC) transporter
GWP43_04060	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWP43_04065	COG3639	organic phosphonate transmembrane transporter activity
GWP43_04085	COG1187	pseudouridine synthase activity
GWP43_04090	COG0217	transcriptional regulatory protein
GWP43_04100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWP43_04110	COG0813	purine-nucleoside phosphorylase activity
GWP43_04220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWP43_04240	COG1396	sequence-specific DNA binding
GWP43_04240	COG3800	Transcriptional regulator
GWP43_04320	COG4974	Belongs to the 'phage' integrase family
GWP43_04350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWP43_04365	COG3588	fructose-bisphosphate aldolase
GWP43_04380	COG1477	protein flavinylation
GWP43_04395	COG1464	Belongs to the NlpA lipoprotein family
GWP43_04405	COG0084	hydrolase, TatD family'
GWP43_04410	COG3116	cell division
GWP43_04410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWP43_04440	COG0488	(ABC) transporter
GWP43_04445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWP43_04455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWP43_04460	COG0363	glucosamine-6-phosphate deaminase activity
GWP43_04465	COG0628	permease
GWP43_04470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWP43_04475	COG0328	RNA-DNA hybrid ribonuclease activity
GWP43_04480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWP43_04495	COG0395	ABC-type sugar transport system, permease component
GWP43_04515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP43_04770	COG1475	DNA binding
GWP43_04775	COG1475	DNA binding
GWP43_05015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP43_05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP43_05165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP43_05170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP43_05175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP43_05180	COG0571	ribonuclease III activity
GWP43_05190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWP43_05215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWP43_05220	COG1960	acyl-CoA dehydrogenase activity
GWP43_05225	COG3290	protein histidine kinase activity
GWP43_05225	COG3829	transcription factor binding
GWP43_05230	COG1024	Enoyl-CoA hydratase
GWP43_05235	COG2610	gluconate transmembrane transporter activity
GWP43_05245	COG1960	acyl-CoA dehydrogenase activity
GWP43_05250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWP43_05260	COG1157	protein secretion by the type III secretion system
GWP43_05265	COG1317	bacterial-type flagellum organization
GWP43_05275	COG1766	The M ring may be actively involved in energy transduction
GWP43_05290	COG1815	bacterial-type flagellum-dependent cell motility
GWP43_05295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWP43_05300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWP43_05305	COG3579	cysteine-type endopeptidase activity
GWP43_05310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWP43_05315	COG0166	Belongs to the GPI family
GWP43_05320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWP43_05340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP43_05350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP43_05355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_05355	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_05370	COG2304	oxidoreductase activity
GWP43_05380	COG0183	Belongs to the thiolase family
GWP43_05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_05390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_05395	COG3842	ATPase activity
GWP43_05405	COG0343	queuine tRNA-ribosyltransferase activity
GWP43_05425	COG2358	TRAP transporter, solute receptor (TAXI family
GWP43_05435	COG0708	Exodeoxyribonuclease III
GWP43_05445	COG2832	Protein of unknown function (DUF454)
GWP43_05450	COG1137	ATPase activity
GWP43_05470	COG0402	S-adenosylhomocysteine deaminase activity
GWP43_05485	COG1120	ATPase activity
GWP43_05490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_05555	COG1509	lysine 2,3-aminomutase activity
GWP43_05560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP43_05575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_05580	COG0840	transmembrane signaling receptor activity
GWP43_05610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP43_05615	COG0617	tRNA 3'-terminal CCA addition
GWP43_05620	COG2703	oxygen carrier activity
GWP43_05625	COG1523	belongs to the glycosyl hydrolase 13 family
GWP43_05630	COG2182	Extracellular solute-binding protein
GWP43_05645	COG1175	transmembrane transport
GWP43_05650	COG3833	ABC-type maltose transport systems, permease component
GWP43_05675	COG3118	belongs to the thioredoxin family
GWP43_05685	COG2198	Histidine kinase
GWP43_05685	COG0643	Histidine kinase
GWP43_05690	COG0835	chemotaxis
GWP43_05700	COG2201	protein-glutamate methylesterase activity
GWP43_05715	COG0731	radical SAM domain protein
GWP43_05735	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWP43_05755	COG0268	Binds directly to 16S ribosomal RNA
GWP43_05765	COG0776	regulation of translation
GWP43_05770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP43_05780	COG1546	Belongs to the CinA family
GWP43_05780	COG1058	Belongs to the CinA family
GWP43_05785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWP43_05790	COG0254	rRNA binding
GWP43_05795	COG1272	protein, Hemolysin III
GWP43_05810	COG1131	(ABC) transporter
GWP43_05820	COG4585	Histidine kinase
GWP43_05835	COG1136	(ABC) transporter
GWP43_05895	COG1129	ABC transporter
GWP43_05900	COG0346	lactoylglutathione lyase activity
GWP43_05910	COG1881	PFAM PEBP family protein
GWP43_05915	COG3340	Belongs to the peptidase S51 family
GWP43_05945	COG0656	L-ascorbic acid biosynthetic process
GWP43_06005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWP43_06050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWP43_06055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWP43_06060	COG1136	(ABC) transporter
GWP43_06060	COG0577	efflux transmembrane transporter activity
GWP43_06065	COG0840	transmembrane signaling receptor activity
GWP43_06070	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_06075	COG3876	Protein conserved in bacteria
GWP43_06090	COG1388	LysM domain
GWP43_06090	COG0741	lytic transglycosylase activity
GWP43_06115	COG3142	Participates in the control of copper homeostasis
GWP43_06135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWP43_06140	COG0714	Associated with various cellular activities
GWP43_06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWP43_06165	COG2890	protein-(glutamine-N5) methyltransferase activity
GWP43_06185	COG4213	ABC transporter substrate-binding protein
GWP43_06195	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP43_06200	COG1070	Carbohydrate kinase
GWP43_06205	COG2115	Belongs to the xylose isomerase family
GWP43_06215	COG3330	Domain of unknown function (DUF4912)
GWP43_06225	COG0588	phosphoglycerate mutase activity
GWP43_06230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWP43_06255	COG2801	Transposase and inactivated derivatives
GWP43_06305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWP43_06310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWP43_06320	COG0736	holo-[acyl-carrier-protein] synthase activity
GWP43_06330	COG0101	tRNA pseudouridine synthase activity
GWP43_06335	COG0523	cobalamin synthesis protein
GWP43_06340	COG0534	Mate efflux family protein
GWP43_06345	COG1522	sequence-specific DNA binding
GWP43_06350	COG0436	Aminotransferase
GWP43_06355	COG0561	phosphatase activity
GWP43_06365	COG4608	Belongs to the ABC transporter superfamily
GWP43_06370	COG0601	transmembrane transport
GWP43_06375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_06420	COG1122	ATPase activity
GWP43_06445	COG0552	protein localization to endoplasmic reticulum
GWP43_06460	COG1136	(ABC) transporter
GWP43_06470	COG0142	geranyltranstransferase activity
GWP43_06480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_06575	COG1309	transcriptional regulator
GWP43_06580	COG1131	(ABC) transporter
GWP43_06765	COG1309	transcriptional regulator
GWP43_06770	COG1132	(ABC) transporter
GWP43_06775	COG1132	(ABC) transporter
GWP43_06780	COG1132	(ABC) transporter
GWP43_06785	COG1132	(ABC) transporter
GWP43_06800	COG4953	penicillin-binding protein 1C
GWP43_06815	COG0724	RNA recognition motif
GWP43_06825	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP43_06835	COG1196	nuclear chromosome segregation
GWP43_06845	COG0733	neurotransmitter:sodium symporter activity
GWP43_06850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWP43_06855	COG0457	Tetratricopeptide repeat
GWP43_06860	COG1704	LemA family
GWP43_06870	COG1132	(ABC) transporter
GWP43_06875	COG1132	(ABC) transporter
GWP43_06890	COG1802	Transcriptional regulator
GWP43_06895	COG0632	four-way junction helicase activity
GWP43_06900	COG1739	Uncharacterized protein family UPF0029
GWP43_06905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWP43_06910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP43_06920	COG0470	DNA polymerase III
GWP43_06935	COG0305	Participates in initiation and elongation during chromosome replication
GWP43_06940	COG0359	binds to the 23S rRNA
GWP43_06945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWP43_06950	COG0629	single-stranded DNA binding
GWP43_06955	COG0360	Binds together with S18 to 16S ribosomal RNA
GWP43_06975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWP43_06980	COG1104	cysteine desulfurase activity
GWP43_07000	COG2208	phosphoserine phosphatase activity
GWP43_07040	COG1230	cation diffusion facilitator family transporter
GWP43_07050	COG1321	iron dependent repressor
GWP43_07055	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP43_07060	COG1121	(ABC) transporter
GWP43_07065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_07070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_07075	COG1683	Conserved Protein
GWP43_07085	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWP43_07095	COG3829	transcription factor binding
GWP43_07095	COG3290	protein histidine kinase activity
GWP43_07120	COG3852	Histidine kinase
GWP43_07130	COG0823	Involved in the tonB-independent uptake of proteins
GWP43_07150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWP43_07180	COG0149	triose-phosphate isomerase activity
GWP43_07190	COG1760	l-serine dehydratase
GWP43_07210	COG3956	TIGRFAM MazG family protein
GWP43_07215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP43_07220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP43_07225	COG2604	Protein of unknown function DUF115
GWP43_07270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWP43_07285	COG1070	Carbohydrate kinase
GWP43_07305	COG2388	GCN5-related N-acetyl-transferase
GWP43_07330	COG0482	sulfurtransferase activity
GWP43_07355	COG0504	CTP synthase activity
GWP43_07385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GWP43_07395	COG1487	ribonuclease activity
GWP43_07420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWP43_07430	COG0569	domain protein
GWP43_07435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWP43_07460	COG1067	ATP-dependent peptidase activity
GWP43_07480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_07500	COG3177	Filamentation induced by cAMP protein fic
GWP43_07505	COG1129	ABC transporter
GWP43_07530	COG1131	(ABC) transporter
GWP43_07565	COG1309	transcriptional regulator
GWP43_07590	COG1129	ABC transporter
GWP43_07630	COG0750	zinc metalloprotease
GWP43_07635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWP43_07640	COG0575	Belongs to the CDS family
GWP43_07645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWP43_07650	COG0233	cytoplasmic translational termination
GWP43_07655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWP43_07660	COG0052	Belongs to the universal ribosomal protein uS2 family
GWP43_07665	COG0424	maF-like protein
GWP43_07675	COG0442	prolyl-tRNA aminoacylation
GWP43_07690	COG5341	Protein conserved in bacteria
GWP43_07695	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWP43_07700	COG0835	chemotaxis
GWP43_07710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWP43_07715	COG0497	DNA recombination
GWP43_07765	COG0427	acetyl-CoA hydrolase
GWP43_07770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWP43_07775	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP43_07800	COG1454	alcohol dehydrogenase
GWP43_07815	COG1234	tRNA 3'-trailer cleavage
GWP43_07825	COG4254	PFAM FecR protein
GWP43_07835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_07840	COG0154	amidase activity
GWP43_07845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_07855	COG2211	Major facilitator Superfamily
GWP43_07890	COG3681	Belongs to the UPF0597 family
GWP43_07895	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP43_07910	COG3597	protein domain associated with
GWP43_07920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWP43_07940	COG1136	(ABC) transporter
GWP43_07945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWP43_07950	COG0193	aminoacyl-tRNA hydrolase activity
GWP43_07960	COG0357	Ribosomal RNA small subunit methyltransferase G
GWP43_07970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWP43_07975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWP43_08005	COG2226	methyltransferase
GWP43_08010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWP43_08025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP43_08030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP43_08035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP43_08050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP43_08080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWP43_08085	COG0519	Catalyzes the synthesis of GMP from XMP
GWP43_08110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWP43_08120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWP43_08125	COG2885	chlorophyll binding
GWP43_08210	COG2373	Large extracellular alpha-helical protein
GWP43_08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWP43_08225	COG0785	Cytochrome C biogenesis protein
GWP43_08240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP43_08245	COG2161	toxin-antitoxin pair type II binding
GWP43_08270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWP43_08270	COG1747	RNA polymerase binding
GWP43_08280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWP43_08300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWP43_08305	COG0297	glycogen (starch) synthase activity
GWP43_08315	COG0791	NLP P60 protein
GWP43_08320	COG0318	PFAM AMP-dependent synthetase and ligase
GWP43_08325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWP43_08350	COG4209	transmembrane transport
GWP43_08355	COG0395	ABC-type sugar transport system, permease component
GWP43_08385	COG0228	four-way junction DNA binding
GWP43_08390	COG1837	Belongs to the UPF0109 family
GWP43_08395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWP43_08400	COG0336	Belongs to the RNA methyltransferase TrmD family
GWP43_08405	COG0335	large ribosomal subunit rRNA binding
GWP43_08445	COG1773	rubredoxin
GWP43_08465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP43_08485	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_08495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP43_08515	COG3657	addiction module killer protein
GWP43_08520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWP43_08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP43_08545	COG1132	(ABC) transporter
GWP43_08545	COG2375	cellular response to nickel ion
GWP43_08555	COG2801	Transposase and inactivated derivatives
GWP43_08590	COG2801	Transposase and inactivated derivatives
GWP43_08700	COG4988	ABC transporter
GWP43_08705	COG1132	(ABC) transporter
GWP43_08710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP43_08730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWP43_08740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWP43_08745	COG0285	dihydrofolate synthase activity
GWP43_08750	COG0564	pseudouridine synthase activity
GWP43_08795	COG0330	HflC and HflK could
GWP43_08800	COG0330	HflC and HflK could
GWP43_08820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP43_08900	COG0848	biopolymer transport protein
GWP43_08905	COG0811	peptide transport
GWP43_08915	COG0455	bacterial-type flagellum organization
GWP43_08925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWP43_08935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWP43_08970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWP43_08975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWP43_08990	COG0564	pseudouridine synthase activity
GWP43_09000	COG3735	TraB family
GWP43_09010	COG0275	rRNA processing
GWP43_09020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWP43_09025	COG0772	Belongs to the SEDS family
GWP43_09030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWP43_09040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWP43_09050	COG1301	dicarboxylic acid transport
GWP43_09060	COG1136	(ABC) transporter
GWP43_09065	COG0577	efflux transmembrane transporter activity
GWP43_09065	COG1136	(ABC) transporter
GWP43_09080	COG0534	Mate efflux family protein
GWP43_09085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWP43_09095	COG1309	transcriptional regulator
GWP43_09115	COG0395	ABC-type sugar transport system, permease component
GWP43_09120	COG1175	transmembrane transport
GWP43_09140	COG2971	BadF BadG BcrA BcrD
GWP43_09145	COG4886	Leucine-rich repeat (LRR) protein
GWP43_09170	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GWP43_09185	COG0732	type I restriction modification DNA specificity domain
GWP43_09205	COG4974	Belongs to the 'phage' integrase family
GWP43_09225	COG0732	type I restriction modification DNA specificity domain
GWP43_09390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWP43_09405	COG1653	transport
GWP43_09435	COG0116	Belongs to the methyltransferase superfamily
GWP43_09435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWP43_09440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWP43_09445	COG1413	lyase activity
GWP43_09460	COG1482	cell wall glycoprotein biosynthetic process
GWP43_09465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWP43_09470	COG1573	uracil-dna glycosylase
GWP43_09490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWP43_09495	COG0563	adenylate kinase activity
GWP43_09505	COG0772	Belongs to the SEDS family
GWP43_09510	COG0768	penicillin binding
GWP43_09525	COG1077	Cell shape determining protein MreB Mrl
GWP43_09545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWP43_09550	COG0358	DNA primase activity
GWP43_09555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWP43_09575	COG3189	MarR family transcriptional regulator
GWP43_09615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWP43_09615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWP43_09620	COG3118	belongs to the thioredoxin family
GWP43_09625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWP43_09645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWP43_09665	COG2801	Transposase and inactivated derivatives
GWP43_09670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWP43_09675	COG0484	heat shock protein binding
GWP43_09680	COG0528	UMP kinase activity
GWP43_09685	COG1305	Transglutaminase-like
GWP43_09700	COG0215	cysteine-tRNA ligase activity
GWP43_09705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWP43_09725	COG2201	protein-glutamate methylesterase activity
GWP43_09765	COG0126	phosphoglycerate kinase activity
GWP43_09810	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWP43_09830	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_09830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_09835	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWP43_09840	COG0318	PFAM AMP-dependent synthetase and ligase
GWP43_09850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_09855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWP43_09855	COG0426	domain, Protein
GWP43_09885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWP43_09890	COG1480	7TM receptor with intracellular HD hydrolase
GWP43_09910	COG0494	nUDIX hydrolase
GWP43_09915	COG0840	transmembrane signaling receptor activity
GWP43_09945	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP43_09950	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP43_09955	COG1924	4 iron, 4 sulfur cluster binding
GWP43_09960	COG0786	glutamate:sodium symporter activity
GWP43_09965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWP43_09970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWP43_09980	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GWP43_09995	COG0786	glutamate:sodium symporter activity
GWP43_10000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP43_10005	COG0840	transmembrane signaling receptor activity
GWP43_10020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_10025	COG0457	Tetratricopeptide repeat
GWP43_10030	COG0037	tRNA processing
GWP43_10035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWP43_10045	COG2088	sporulation resulting in formation of a cellular spore
GWP43_10055	COG0537	adenosine 5'-monophosphoramidase activity
GWP43_10060	COG1022	Amp-dependent synthetase and ligase
GWP43_10070	COG0737	Belongs to the 5'-nucleotidase family
GWP43_10090	COG0514	ATP-dependent DNA helicase (RecQ)
GWP43_10105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWP43_10115	COG0596	Alpha beta hydrolase
GWP43_10140	COG1309	transcriptional regulator
GWP43_10145	COG1132	(ABC) transporter
GWP43_10145	COG2375	cellular response to nickel ion
GWP43_10150	COG1132	(ABC) transporter
GWP43_10155	COG1129	ABC transporter
GWP43_10160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GWP43_10170	COG2226	methyltransferase
GWP43_10185	COG0534	Mate efflux family protein
GWP43_10190	COG1309	transcriptional regulator
GWP43_10200	COG0488	(ABC) transporter
GWP43_10220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP43_10235	COG0049	tRNA binding
GWP43_10250	COG0085	RNA polymerase activity
GWP43_10255	COG0222	ribosome binding
GWP43_10260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWP43_10265	COG0081	regulation of translation
GWP43_10270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWP43_10275	COG0250	Participates in transcription elongation, termination and antitermination
GWP43_10280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP43_10290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWP43_10305	COG1438	arginine binding
GWP43_10310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWP43_10335	COG0301	tRNA thio-modification
GWP43_10345	COG2502	aspartate--ammonia ligase
GWP43_10375	COG0739	heme binding
GWP43_10390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWP43_10400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP43_10405	COG2911	Protein conserved in bacteria
GWP43_10410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWP43_10420	COG0739	heme binding
GWP43_10435	COG1774	PSP1 C-terminal conserved region
GWP43_10455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWP43_10460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWP43_10465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWP43_10475	COG0427	acetyl-CoA hydrolase
GWP43_10480	COG1024	Enoyl-CoA hydratase
GWP43_10485	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP43_10490	COG1309	transcriptional regulator
GWP43_10495	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_10495	COG3848	Pyruvate phosphate dikinase
GWP43_10505	COG0668	transmembrane transport
GWP43_10510	COG1840	ABC-type Fe3 transport system, periplasmic component
GWP43_10515	COG3842	ATPase activity
GWP43_10525	COG1737	Transcriptional regulator
GWP43_10535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWP43_10540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWP43_10545	COG0284	orotidine-5'-phosphate decarboxylase activity
GWP43_10550	COG0167	dihydroorotate dehydrogenase activity
GWP43_10555	COG0543	2 iron, 2 sulfur cluster binding
GWP43_10560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWP43_10565	COG0540	Belongs to the ATCase OTCase family
GWP43_10585	COG1132	(ABC) transporter
GWP43_10585	COG2375	cellular response to nickel ion
GWP43_10590	COG0500	methyltransferase
GWP43_10600	COG1132	(ABC) transporter
GWP43_10605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWP43_10610	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GWP43_10630	COG2361	Protein of unknown function DUF86
GWP43_10680	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_10685	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP43_10690	COG3845	ABC transporter
GWP43_10695	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_10700	COG0840	transmembrane signaling receptor activity
GWP43_10705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWP43_10725	COG0709	Synthesizes selenophosphate from selenide and ATP
GWP43_10730	COG0556	nucleotide-excision repair
GWP43_10735	COG0740	serine-type endopeptidase activity
GWP43_10760	COG0681	Belongs to the peptidase S26 family
GWP43_10765	COG0840	transmembrane signaling receptor activity
GWP43_10800	COG0300	oxidoreductase activity
GWP43_10810	COG0789	Transcriptional regulator
GWP43_10810	COG4978	Transcriptional regulator
GWP43_10815	COG1288	antiporter activity
GWP43_10825	COG1288	antiporter activity
GWP43_10885	COG1960	acyl-CoA dehydrogenase activity
GWP43_10890	COG1012	belongs to the aldehyde dehydrogenase family
GWP43_10900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWP43_10915	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GWP43_10940	COG1061	Type III restriction enzyme res subunit
GWP43_10945	COG3437	response regulator, receiver
GWP43_10945	COG2770	Histidine kinase
GWP43_10955	COG0802	atpase or kinase
GWP43_10960	COG0564	pseudouridine synthase activity
GWP43_10970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWP43_11010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP43_11015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP43_11025	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_11035	COG3845	ABC transporter
GWP43_11040	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_11055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWP43_11070	COG1570	exodeoxyribonuclease VII activity
GWP43_11115	COG0719	Fe-S assembly protein
GWP43_11125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWP43_11130	COG1692	metallophosphoesterase
GWP43_11145	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWP43_11160	COG1653	transport
GWP43_11165	COG1175	transmembrane transport
GWP43_11170	COG0395	ABC-type sugar transport system, permease component
GWP43_11180	COG0295	cytidine deaminase activity
GWP43_11190	COG0739	heme binding
GWP43_11215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWP43_11230	COG3876	Protein conserved in bacteria
GWP43_11235	COG2239	Acts as a magnesium transporter
GWP43_11240	COG0170	dolichyl monophosphate biosynthetic process
GWP43_11260	COG1132	(ABC) transporter
GWP43_11265	COG1132	(ABC) transporter
GWP43_11265	COG2375	cellular response to nickel ion
GWP43_11275	COG1487	ribonuclease activity
GWP43_11285	COG1309	transcriptional regulator
GWP43_11290	COG0617	tRNA 3'-terminal CCA addition
GWP43_11290	COG0617	tRNA 3'-terminal CCA addition
GWP43_11315	COG1205	dead DEAH box helicase
GWP43_11315	COG1111	helicase
GWP43_11340	COG0484	heat shock protein binding
GWP43_11345	COG0443	Heat shock 70 kDa protein
GWP43_11350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWP43_11390	COG1609	Transcriptional regulator
GWP43_11415	COG3250	beta-galactosidase activity
GWP43_11425	COG0395	ABC-type sugar transport system, permease component
GWP43_11430	COG1175	transmembrane transport
GWP43_11440	COG5002	protein histidine kinase activity
GWP43_11445	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP43_11455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWP43_11455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWP43_11455	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWP43_11455	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWP43_11475	COG1846	Transcriptional regulator
GWP43_11495	COG3842	ATPase activity
GWP43_11500	COG0483	inositol monophosphate 1-phosphatase activity
GWP43_11515	COG4585	Histidine kinase
GWP43_11595	COG3550	peptidyl-serine autophosphorylation
GWP43_11605	COG1309	transcriptional regulator
GWP43_11620	COG1129	ABC transporter
GWP43_11660	COG1846	Transcriptional regulator
GWP43_11685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWP43_11710	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
GWP43_11725	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GWP43_11730	COG1394	ATPase activity, coupled to movement of substances
GWP43_11735	COG1269	ATP hydrolysis coupled proton transport
GWP43_11750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWP43_11760	COG0840	transmembrane signaling receptor activity
GWP43_11780	COG1199	ATP-dependent helicase activity
GWP43_11800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWP43_11815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP43_11855	COG1733	regulation of RNA biosynthetic process
GWP43_11900	COG3708	Transcriptional regulator
GWP43_11900	COG2207	Transcriptional regulator
GWP43_11910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP43_11915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP43_11920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWP43_11925	COG0402	S-adenosylhomocysteine deaminase activity
GWP43_11960	COG0732	type I restriction modification DNA specificity domain
GWP43_12005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWP43_12010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_12020	COG0457	Tetratricopeptide repeat
GWP43_12025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWP43_12075	COG1254	Belongs to the acylphosphatase family
GWP43_12095	COG1193	negative regulation of DNA recombination
GWP43_12110	COG0433	COG0433 Predicted ATPase
GWP43_12115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWP43_12120	COG1722	exodeoxyribonuclease VII activity
GWP43_12230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWP43_12240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_12265	COG0793	Belongs to the peptidase S41A family
GWP43_12290	COG3093	addiction module antidote protein HigA
GWP43_12305	COG0203	ribosomal protein L17
GWP43_12310	COG0202	RNA polymerase activity
GWP43_12315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWP43_12325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWP43_12335	COG0200	Binds to the 23S rRNA
GWP43_12345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWP43_12360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWP43_12370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWP43_12375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWP43_12380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWP43_12385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWP43_12390	COG0255	Belongs to the universal ribosomal protein uL29 family
GWP43_12400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWP43_12415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWP43_12420	COG0089	rRNA binding
GWP43_12425	COG0088	Forms part of the polypeptide exit tunnel
GWP43_12430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWP43_12435	COG0051	transcription antitermination factor activity, RNA binding
GWP43_12440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWP43_12455	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWP43_12460	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWP43_12465	COG4149	molybdate abc transporter
GWP43_12500	COG0741	lytic transglycosylase activity
GWP43_12505	COG1968	undecaprenyl-diphosphatase activity
GWP43_12510	COG1674	ftsk spoiiie
GWP43_12535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP43_12545	COG0084	hydrolase, TatD family'
GWP43_12555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWP43_12845	COG1846	Transcriptional regulator
GWP43_12850	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GWP43_12890	COG0629	single-stranded DNA binding
GWP43_12960	COG0714	Associated with various cellular activities
GWP43_12970	COG0826	peptidase U32
GWP43_12980	COG0822	iron-sulfur transferase activity
GWP43_12985	COG0564	pseudouridine synthase activity
GWP43_13010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWP43_13030	COG1695	Transcriptional regulator
GWP43_13040	COG1983	PspC domain protein
GWP43_13090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_13090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_13090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_13100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWP43_13105	COG1640	4-alpha-glucanotransferase
GWP43_13125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWP43_13145	COG4443	Transcriptional Coactivator p15 (PC4)
GWP43_13220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_13235	COG0420	3'-5' exonuclease activity
GWP43_13240	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP43_13255	COG0728	peptidoglycan biosynthetic process
GWP43_13265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWP43_13280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWP43_13295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWP43_13295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWP43_13300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_13305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_13330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWP43_13420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWP43_13605	COG0492	ferredoxin-NADP+ reductase activity
GWP43_13610	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_13615	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GWP43_13625	COG0237	dephospho-CoA kinase activity
GWP43_13635	COG0739	heme binding
GWP43_13650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWP43_13655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWP43_13680	COG1177	transmembrane transport
GWP43_13685	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWP43_13690	COG3842	ATPase activity
GWP43_13695	COG0116	Belongs to the methyltransferase superfamily
GWP43_13700	COG0701	Predicted permease
GWP43_13720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWP43_13750	COG0012	GTP binding
GWP43_13755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWP43_13765	COG0071	Belongs to the small heat shock protein (HSP20) family
GWP43_13770	COG0019	diaminopimelate decarboxylase activity
GWP43_13775	COG0716	FMN binding
GWP43_13785	COG1956	GAF domain-containing protein
GWP43_13795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWP43_13800	COG1136	(ABC) transporter
GWP43_13815	COG0561	phosphatase activity
GWP43_13830	COG1136	(ABC) transporter
GWP43_13830	COG0577	efflux transmembrane transporter activity
GWP43_13835	COG0577	efflux transmembrane transporter activity
GWP43_13835	COG1136	(ABC) transporter
GWP43_13840	COG0840	transmembrane signaling receptor activity
GWP43_13845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWP43_13850	COG0423	glycine-tRNA ligase activity
GWP43_13860	COG0584	glycerophosphoryl diester phosphodiesterase
GWP43_13865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWP43_13865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWP43_13875	COG0205	6-phosphofructokinase activity
GWP43_13880	COG0516	GMP reductase activity
GWP43_13880	COG0517	IMP dehydrogenase activity
GWP43_13890	COG1028	Short-chain dehydrogenase reductase Sdr
GWP43_13895	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWP43_13900	COG2204	response regulator
GWP43_13940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWP43_13970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP43_13975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWP43_14000	COG0739	heme binding
GWP43_14010	COG0545	Peptidyl-prolyl cis-trans isomerase
GWP43_14020	COG2378	regulation of single-species biofilm formation
GWP43_14045	COG0464	growth
GWP43_14055	COG1309	transcriptional regulator
GWP43_14070	COG1129	ABC transporter
GWP43_14080	COG1132	(ABC) transporter
GWP43_14120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWP43_14150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWP43_14155	COG0592	DNA-directed DNA polymerase activity
GWP43_14160	COG2089	acid synthase
GWP43_14175	COG4750	Nucleotidyl transferase
GWP43_14185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities