locus-tag	class	description
GWP40_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWP40_00030	COG1177	transmembrane transport
GWP40_00035	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWP40_00040	COG3842	ATPase activity
GWP40_00055	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP40_00060	COG1129	ABC transporter
GWP40_00065	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP40_00070	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP40_00075	COG4942	peptidase
GWP40_00090	COG3177	Filamentation induced by cAMP protein fic
GWP40_00110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP40_00115	COG1253	flavin adenine dinucleotide binding
GWP40_00120	COG4536	flavin adenine dinucleotide binding
GWP40_00130	COG3118	belongs to the thioredoxin family
GWP40_00135	COG1692	metallophosphoesterase
GWP40_00140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWP40_00160	COG0719	Fe-S assembly protein
GWP40_00200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWP40_00210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWP40_00215	COG4750	Nucleotidyl transferase
GWP40_00220	COG0039	L-malate dehydrogenase activity
GWP40_00235	COG0500	methyltransferase
GWP40_00240	COG2375	cellular response to nickel ion
GWP40_00240	COG1132	(ABC) transporter
GWP40_00275	COG0534	Mate efflux family protein
GWP40_00285	COG1309	transcriptional regulator
GWP40_00310	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP40_00315	COG1024	Enoyl-CoA hydratase
GWP40_00320	COG0427	acetyl-CoA hydrolase
GWP40_00360	COG0203	ribosomal protein L17
GWP40_00365	COG0202	RNA polymerase activity
GWP40_00370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWP40_00380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWP40_00400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWP40_00410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWP40_00415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWP40_00425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWP40_00430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWP40_00435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWP40_00440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWP40_00445	COG0255	Belongs to the universal ribosomal protein uL29 family
GWP40_00455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWP40_00460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWP40_00470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWP40_00475	COG0089	rRNA binding
GWP40_00480	COG0088	Forms part of the polypeptide exit tunnel
GWP40_00485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWP40_00490	COG0051	transcription antitermination factor activity, RNA binding
GWP40_00495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWP40_00510	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWP40_00515	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWP40_00520	COG4149	molybdate abc transporter
GWP40_00585	COG0741	lytic transglycosylase activity
GWP40_00590	COG1968	undecaprenyl-diphosphatase activity
GWP40_00595	COG1674	ftsk spoiiie
GWP40_00615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP40_00625	COG0084	hydrolase, TatD family'
GWP40_00635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWP40_00690	COG0714	Associated with various cellular activities
GWP40_00715	COG3621	Patatin-like phospholipase
GWP40_00745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWP40_00750	COG0826	peptidase U32
GWP40_00775	COG0822	iron-sulfur transferase activity
GWP40_00780	COG2255	four-way junction helicase activity
GWP40_00790	COG0445	tRNA wobble uridine modification
GWP40_00800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWP40_00820	COG1757	Na H antiporter
GWP40_00825	COG2203	Gaf domain
GWP40_00825	COG2199	diguanylate cyclase activity
GWP40_00830	COG3706	GGDEF domain
GWP40_00850	COG0488	(ABC) transporter
GWP40_00855	COG0438	transferase activity, transferring glycosyl groups
GWP40_00855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP40_00870	COG0673	inositol 2-dehydrogenase activity
GWP40_00875	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_00880	COG1129	ABC transporter
GWP40_00885	COG1879	ABC-type sugar transport system periplasmic component
GWP40_00905	COG0191	fructose-bisphosphate aldolase activity
GWP40_00910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP40_00920	COG1349	DNA-binding transcription factor activity
GWP40_00925	COG1012	belongs to the aldehyde dehydrogenase family
GWP40_00940	COG0425	Belongs to the sulfur carrier protein TusA family
GWP40_00965	COG0733	neurotransmitter:sodium symporter activity
GWP40_00980	COG0543	2 iron, 2 sulfur cluster binding
GWP40_00985	COG1639	'signal transduction protein
GWP40_00990	COG1121	(ABC) transporter
GWP40_00995	COG1695	Transcriptional regulator
GWP40_01005	COG1983	PspC domain protein
GWP40_01055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP40_01055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_01055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_01065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWP40_01085	COG4452	Inner membrane protein CreD
GWP40_01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWP40_01115	COG2885	chlorophyll binding
GWP40_01120	COG0739	heme binding
GWP40_01130	COG1114	Component of the transport system for branched-chain amino acids
GWP40_01135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWP40_01140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWP40_01145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWP40_01150	COG0423	glycine-tRNA ligase activity
GWP40_01160	COG0584	glycerophosphoryl diester phosphodiesterase
GWP40_01170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWP40_01170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWP40_01180	COG0205	6-phosphofructokinase activity
GWP40_01195	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_01200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWP40_01205	COG2204	response regulator
GWP40_01245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWP40_01280	COG0640	Transcriptional regulator
GWP40_01295	COG0110	maltose O-acetyltransferase activity
GWP40_01375	COG0484	heat shock protein binding
GWP40_01380	COG0024	Methionine aminopeptidase
GWP40_01415	COG2089	acid synthase
GWP40_01420	COG0592	DNA-directed DNA polymerase activity
GWP40_01425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWP40_01480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWP40_01555	COG2378	regulation of single-species biofilm formation
GWP40_01565	COG2815	serine threonine protein kinase
GWP40_01565	COG0515	serine threonine protein kinase
GWP40_01575	COG1132	(ABC) transporter
GWP40_01585	COG0545	Peptidyl-prolyl cis-trans isomerase
GWP40_01590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWP40_01595	COG1881	PFAM PEBP family protein
GWP40_01625	COG0739	heme binding
GWP40_01630	COG1686	Belongs to the peptidase S11 family
GWP40_01650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWP40_01655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP40_01710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP40_01710	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_01720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWP40_01735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP40_01740	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWP40_01805	COG1131	(ABC) transporter
GWP40_01825	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_01830	COG0511	ligase activity, forming carbon-carbon bonds
GWP40_01830	COG5016	pyruvate
GWP40_01835	COG1115	amino acid carrier protein
GWP40_01840	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP40_01845	COG3437	response regulator, receiver
GWP40_01850	COG1671	Belongs to the UPF0178 family
GWP40_01855	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWP40_01870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWP40_01890	COG0351	phosphomethylpyrimidine kinase
GWP40_01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_01910	COG1120	ATPase activity
GWP40_01915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWP40_01920	COG3585	molybdate ion transport
GWP40_01945	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP40_01950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_01960	COG2011	ABC-type metal ion transport system permease component
GWP40_01970	COG1879	ABC-type sugar transport system periplasmic component
GWP40_01980	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_01985	COG1129	ABC transporter
GWP40_01995	COG1070	Carbohydrate kinase
GWP40_02015	COG1175	transmembrane transport
GWP40_02020	COG0395	ABC-type sugar transport system, permease component
GWP40_02040	COG0840	transmembrane signaling receptor activity
GWP40_02105	COG0037	tRNA processing
GWP40_02150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_02155	COG4977	sequence-specific DNA binding
GWP40_02155	COG1917	Cupin 2, conserved barrel domain protein
GWP40_02170	COG1129	ABC transporter
GWP40_02175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP40_02195	COG0739	heme binding
GWP40_02220	COG1129	ABC transporter
GWP40_02275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWP40_02290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP40_02295	COG0156	8-amino-7-oxononanoate synthase activity
GWP40_02330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWP40_02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_02340	COG1120	ATPase activity
GWP40_02345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWP40_02370	COG1193	negative regulation of DNA recombination
GWP40_02380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWP40_02425	COG0629	single-stranded DNA binding
GWP40_02430	COG0281	malic enzyme
GWP40_02435	COG0513	Belongs to the DEAD box helicase family
GWP40_02440	COG0438	transferase activity, transferring glycosyl groups
GWP40_02475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWP40_02480	COG0706	membrane insertase activity
GWP40_02485	COG1847	R3H domain protein
GWP40_02495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWP40_02500	COG1862	Preprotein translocase
GWP40_02505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP40_02510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP40_02515	COG1040	competence protein
GWP40_02525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWP40_02535	COG0058	SHG alpha-glucan phosphorylase activity
GWP40_02550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWP40_02555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_02565	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GWP40_02570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWP40_02575	COG0457	Tetratricopeptide repeat
GWP40_02580	COG0733	neurotransmitter:sodium symporter activity
GWP40_02585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWP40_02600	COG0519	Catalyzes the synthesis of GMP from XMP
GWP40_02635	COG0481	GTPase activity
GWP40_02650	COG0018	arginyl-trna synthetase
GWP40_02655	COG2235	arginine
GWP40_02660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP40_02670	COG1288	antiporter activity
GWP40_02680	COG0653	protein targeting
GWP40_02695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWP40_02710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWP40_02760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP40_02765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP40_02770	COG0783	Belongs to the Dps family
GWP40_02775	COG0326	Molecular chaperone. Has ATPase activity
GWP40_02785	COG0681	Belongs to the peptidase S26 family
GWP40_02795	COG0740	serine-type endopeptidase activity
GWP40_02800	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP40_02810	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP40_02815	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP40_02920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWP40_02925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP40_02930	COG4251	negative regulation of phosphorylation
GWP40_02930	COG3706	GGDEF domain
GWP40_02930	COG2203	Gaf domain
GWP40_02930	COG5001	Diguanylate cyclase
GWP40_02935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_02940	COG0205	6-phosphofructokinase activity
GWP40_02945	COG4211	Belongs to the binding-protein-dependent transport system permease family
GWP40_02950	COG1129	ABC transporter
GWP40_02955	COG1879	ABC-type sugar transport system periplasmic component
GWP40_02970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWP40_02975	COG0012	GTP binding
GWP40_03010	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_03020	COG4978	Transcriptional regulator
GWP40_03020	COG0789	Transcriptional regulator
GWP40_03025	COG1288	antiporter activity
GWP40_03035	COG1288	antiporter activity
GWP40_03040	COG2887	Belongs to the helicase family. UvrD subfamily
GWP40_03060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP40_03090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_03160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWP40_03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWP40_03225	COG0577	efflux transmembrane transporter activity
GWP40_03225	COG1136	(ABC) transporter
GWP40_03265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP40_03290	COG2183	response to ionizing radiation
GWP40_03325	COG0395	ABC-type sugar transport system, permease component
GWP40_03330	COG4209	transmembrane transport
GWP40_03350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWP40_03355	COG1570	exodeoxyribonuclease VII activity
GWP40_03375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWP40_03385	COG0450	alkyl hydroperoxide reductase
GWP40_03395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWP40_03400	COG0071	Belongs to the small heat shock protein (HSP20) family
GWP40_03405	COG0019	diaminopimelate decarboxylase activity
GWP40_03410	COG0716	FMN binding
GWP40_03420	COG1956	GAF domain-containing protein
GWP40_03430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_03440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWP40_03445	COG1245	4Fe-4S binding domain
GWP40_03445	COG2878	Part of a membrane complex involved in electron transport
GWP40_03450	COG4657	Part of a membrane complex involved in electron transport
GWP40_03460	COG4659	FMN binding
GWP40_03465	COG4658	electron transport chain
GWP40_03475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWP40_03490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWP40_03495	COG0825	malonyl-CoA metabolic process
GWP40_03505	COG0540	Belongs to the ATCase OTCase family
GWP40_03510	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWP40_03515	COG0543	2 iron, 2 sulfur cluster binding
GWP40_03520	COG0167	dihydroorotate dehydrogenase activity
GWP40_03525	COG0284	orotidine-5'-phosphate decarboxylase activity
GWP40_03530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWP40_03535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWP40_03545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP40_03555	COG0613	PHP domain protein
GWP40_03645	COG0564	pseudouridine synthase activity
GWP40_03650	COG0588	phosphoglycerate mutase activity
GWP40_03675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP40_03705	COG0419	ATPase involved in DNA repair
GWP40_03715	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP40_03720	COG1757	Na H antiporter
GWP40_03730	COG0728	peptidoglycan biosynthetic process
GWP40_03740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWP40_03770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWP40_03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWP40_03775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_03780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_03795	COG0459	protein refolding
GWP40_03820	COG0280	phosphate acetyltransferase
GWP40_03825	COG0492	ferredoxin-NADP+ reductase activity
GWP40_03830	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_03835	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GWP40_03840	COG1966	Carbon starvation protein
GWP40_03890	COG1102	Psort location Cytoplasmic, score
GWP40_03900	COG0840	transmembrane signaling receptor activity
GWP40_03905	COG0793	Belongs to the peptidase S41A family
GWP40_03945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWP40_03965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWP40_04025	COG0762	integral membrane protein
GWP40_04030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GWP40_04035	COG0180	Tryptophanyl-tRNA synthetase
GWP40_04040	COG0670	Belongs to the BI1 family
GWP40_04055	COG0322	excinuclease ABC activity
GWP40_04085	COG1774	PSP1 C-terminal conserved region
GWP40_04100	COG0739	heme binding
GWP40_04110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWP40_04115	COG2911	Protein conserved in bacteria
GWP40_04120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP40_04155	COG0739	heme binding
GWP40_04190	COG2502	aspartate--ammonia ligase
GWP40_04200	COG0301	tRNA thio-modification
GWP40_04215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWP40_04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_04265	COG1193	negative regulation of DNA recombination
GWP40_04330	COG2604	Protein of unknown function DUF115
GWP40_04335	COG0768	penicillin binding
GWP40_04355	COG0494	nUDIX hydrolase
GWP40_04380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWP40_04385	COG0457	Tetratricopeptide repeat
GWP40_04390	COG1418	mRNA catabolic process
GWP40_04450	COG1132	(ABC) transporter
GWP40_04460	COG1132	(ABC) transporter
GWP40_04470	COG1132	(ABC) transporter
GWP40_04470	COG2375	cellular response to nickel ion
GWP40_04475	COG4977	sequence-specific DNA binding
GWP40_04475	COG1917	Cupin 2, conserved barrel domain protein
GWP40_04485	COG0747	negative chemotaxis
GWP40_04490	COG0601	transmembrane transport
GWP40_04495	COG0601	transmembrane transport
GWP40_04505	COG4172	Belongs to the ABC transporter superfamily
GWP40_04555	COG1120	ATPase activity
GWP40_04560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_04630	COG0402	S-adenosylhomocysteine deaminase activity
GWP40_04640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP40_04645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP40_04660	COG2207	Transcriptional regulator
GWP40_04660	COG3708	Transcriptional regulator
GWP40_04700	COG1124	(ABC) transporter
GWP40_04705	COG0747	negative chemotaxis
GWP40_04710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP40_04735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWP40_04745	COG1199	ATP-dependent helicase activity
GWP40_04765	COG0840	transmembrane signaling receptor activity
GWP40_04775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWP40_04785	COG0840	transmembrane signaling receptor activity
GWP40_04795	COG1269	ATP hydrolysis coupled proton transport
GWP40_04800	COG1394	ATPase activity, coupled to movement of substances
GWP40_04805	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GWP40_04810	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GWP40_04820	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
GWP40_04830	COG4115	mRNA cleavage
GWP40_04840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWP40_04840	COG0456	acetyltransferase
GWP40_04885	COG1129	ABC transporter
GWP40_04900	COG1132	(ABC) transporter
GWP40_04905	COG2375	cellular response to nickel ion
GWP40_04905	COG1132	(ABC) transporter
GWP40_04955	COG0656	L-ascorbic acid biosynthetic process
GWP40_05005	COG2358	TRAP transporter, solute receptor (TAXI family
GWP40_05015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP40_05040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWP40_05050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWP40_05055	COG0772	Belongs to the SEDS family
GWP40_05060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWP40_05070	COG0275	rRNA processing
GWP40_05075	COG2001	Belongs to the MraZ family
GWP40_05080	COG3735	TraB family
GWP40_05090	COG0564	pseudouridine synthase activity
GWP40_05105	COG4166	transmembrane transport
GWP40_05140	COG0235	Class ii aldolase
GWP40_05145	COG1070	Carbohydrate kinase
GWP40_05160	COG3189	MarR family transcriptional regulator
GWP40_05170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWP40_05180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWP40_05190	COG0840	transmembrane signaling receptor activity
GWP40_05195	COG0318	PFAM AMP-dependent synthetase and ligase
GWP40_05200	COG0791	NLP P60 protein
GWP40_05215	COG0617	tRNA 3'-terminal CCA addition
GWP40_05225	COG2252	PERMEase
GWP40_05240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWP40_05245	COG0443	Heat shock 70 kDa protein
GWP40_05250	COG0484	heat shock protein binding
GWP40_05265	COG0170	dolichyl monophosphate biosynthetic process
GWP40_05270	COG2239	Acts as a magnesium transporter
GWP40_05280	COG3876	Protein conserved in bacteria
GWP40_05295	COG0746	molybdenum cofactor guanylyltransferase activity
GWP40_05320	COG0739	heme binding
GWP40_05330	COG0295	cytidine deaminase activity
GWP40_05335	COG1027	Aspartate ammonia-lyase
GWP40_05385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWP40_05385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWP40_05390	COG0564	pseudouridine synthase activity
GWP40_05425	COG1129	ABC transporter
GWP40_05450	COG1129	ABC transporter
GWP40_05455	COG3177	Filamentation induced by cAMP protein fic
GWP40_05485	COG0427	acetyl-CoA hydrolase
GWP40_05490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWP40_05495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP40_05520	COG1454	alcohol dehydrogenase
GWP40_05525	COG0802	atpase or kinase
GWP40_05535	COG2770	Histidine kinase
GWP40_05535	COG3437	response regulator, receiver
GWP40_05545	COG1175	transmembrane transport
GWP40_05575	COG0488	(ABC) transporter
GWP40_05590	COG2703	oxygen carrier activity
GWP40_05595	COG1523	belongs to the glycosyl hydrolase 13 family
GWP40_05600	COG2182	Extracellular solute-binding protein
GWP40_05610	COG1175	transmembrane transport
GWP40_05615	COG3833	ABC-type maltose transport systems, permease component
GWP40_05620	COG0840	transmembrane signaling receptor activity
GWP40_05640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWP40_05640	COG0426	domain, Protein
GWP40_05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_05650	COG0318	PFAM AMP-dependent synthetase and ligase
GWP40_05700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP40_05710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP40_05730	COG2304	oxidoreductase activity
GWP40_05740	COG0183	Belongs to the thiolase family
GWP40_05750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_05750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_05755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWP40_05765	COG1157	protein secretion by the type III secretion system
GWP40_05770	COG1317	bacterial-type flagellum organization
GWP40_05780	COG1766	The M ring may be actively involved in energy transduction
GWP40_05800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWP40_05805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWP40_05810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWP40_05815	COG0672	)-iron permease
GWP40_05820	COG3470	protein probably involved in high-affinity Fe2 transport
GWP40_05840	COG1136	(ABC) transporter
GWP40_05860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP40_05875	COG1309	transcriptional regulator
GWP40_05880	COG0534	Mate efflux family protein
GWP40_05895	COG2226	methyltransferase
GWP40_05925	COG0596	Alpha beta hydrolase
GWP40_05935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWP40_05940	COG0840	transmembrane signaling receptor activity
GWP40_05950	COG0514	ATP-dependent DNA helicase (RecQ)
GWP40_05975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWP40_05980	COG0737	Belongs to the 5'-nucleotidase family
GWP40_05990	COG0537	adenosine 5'-monophosphoramidase activity
GWP40_05995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWP40_06000	COG2088	sporulation resulting in formation of a cellular spore
GWP40_06010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWP40_06015	COG0037	tRNA processing
GWP40_06025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_06115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWP40_06120	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWP40_06170	COG2971	BadF BadG BcrA BcrD
GWP40_06190	COG1573	uracil-dna glycosylase
GWP40_06200	COG1482	cell wall glycoprotein biosynthetic process
GWP40_06225	COG0495	leucyl-tRNA aminoacylation
GWP40_06260	COG0402	S-adenosylhomocysteine deaminase activity
GWP40_06265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWP40_06265	COG0493	'glutamate synthase
GWP40_06285	COG1137	ATPase activity
GWP40_06290	COG2832	Protein of unknown function (DUF454)
GWP40_06300	COG0708	Exodeoxyribonuclease III
GWP40_06320	COG1747	RNA polymerase binding
GWP40_06320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWP40_06330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP40_06335	COG3956	TIGRFAM MazG family protein
GWP40_06345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWP40_06350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWP40_06360	COG0736	holo-[acyl-carrier-protein] synthase activity
GWP40_06370	COG0101	tRNA pseudouridine synthase activity
GWP40_06375	COG0523	cobalamin synthesis protein
GWP40_06380	COG0534	Mate efflux family protein
GWP40_06385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWP40_06395	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_06400	COG3876	Protein conserved in bacteria
GWP40_06410	COG2885	chlorophyll binding
GWP40_06415	COG1388	LysM domain
GWP40_06415	COG0741	lytic transglycosylase activity
GWP40_06425	COG4115	mRNA cleavage
GWP40_06435	COG0166	Belongs to the GPI family
GWP40_06445	COG1413	lyase activity
GWP40_06460	COG0205	6-phosphofructokinase activity
GWP40_06465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWP40_06485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP40_06490	COG1132	(ABC) transporter
GWP40_06495	COG4988	ABC transporter
GWP40_06500	COG3842	ATPase activity
GWP40_06535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP40_06550	COG2885	chlorophyll binding
GWP40_06555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWP40_06595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWP40_06600	COG0358	DNA primase activity
GWP40_06605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWP40_06625	COG1077	Cell shape determining protein MreB Mrl
GWP40_06645	COG0772	Belongs to the SEDS family
GWP40_06650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP40_06655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP40_06660	COG3681	Belongs to the UPF0597 family
GWP40_06675	COG1704	LemA family
GWP40_06685	COG1132	(ABC) transporter
GWP40_06690	COG1132	(ABC) transporter
GWP40_06705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWP40_06730	COG0497	DNA recombination
GWP40_06735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWP40_06740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_06745	COG0835	chemotaxis
GWP40_06755	COG5341	Protein conserved in bacteria
GWP40_06760	COG0442	prolyl-tRNA aminoacylation
GWP40_06765	COG0424	maF-like protein
GWP40_06770	COG0052	Belongs to the universal ribosomal protein uS2 family
GWP40_06775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWP40_06780	COG0233	cytoplasmic translational termination
GWP40_06785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWP40_06790	COG0575	Belongs to the CDS family
GWP40_06795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWP40_06810	COG0750	zinc metalloprotease
GWP40_06825	COG1309	transcriptional regulator
GWP40_06835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP40_06875	COG0714	Associated with various cellular activities
GWP40_06890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWP40_06930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWP40_06945	COG4213	ABC transporter substrate-binding protein
GWP40_06955	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_06960	COG1070	Carbohydrate kinase
GWP40_06965	COG2115	Belongs to the xylose isomerase family
GWP40_06975	COG3330	Domain of unknown function (DUF4912)
GWP40_06985	COG0588	phosphoglycerate mutase activity
GWP40_06990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWP40_07000	COG1131	(ABC) transporter
GWP40_07035	COG1131	(ABC) transporter
GWP40_07045	COG1086	Polysaccharide biosynthesis protein
GWP40_07065	COG1760	l-serine dehydratase
GWP40_07070	COG1760	l-serine dehydratase
GWP40_07075	COG0149	triose-phosphate isomerase activity
GWP40_07110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWP40_07130	COG0823	Involved in the tonB-independent uptake of proteins
GWP40_07135	COG2204	response regulator
GWP40_07140	COG3852	Histidine kinase
GWP40_07150	COG3290	protein histidine kinase activity
GWP40_07150	COG3829	transcription factor binding
GWP40_07160	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWP40_07170	COG1683	Conserved Protein
GWP40_07175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_07185	COG1121	(ABC) transporter
GWP40_07190	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP40_07195	COG1321	iron dependent repressor
GWP40_07200	COG0632	four-way junction helicase activity
GWP40_07205	COG1739	Uncharacterized protein family UPF0029
GWP40_07210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWP40_07215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP40_07225	COG0470	DNA polymerase III
GWP40_07245	COG0359	binds to the 23S rRNA
GWP40_07250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWP40_07255	COG0629	single-stranded DNA binding
GWP40_07260	COG0360	Binds together with S18 to 16S ribosomal RNA
GWP40_07285	COG2211	Major facilitator Superfamily
GWP40_07295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_07305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_07315	COG4254	PFAM FecR protein
GWP40_07325	COG1234	tRNA 3'-trailer cleavage
GWP40_07335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWP40_07345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWP40_07355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWP40_07360	COG2208	phosphoserine phosphatase activity
GWP40_07380	COG1914	H( )-stimulated, divalent metal cation uptake system
GWP40_07385	COG1414	Transcriptional regulator
GWP40_07405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWP40_07410	COG0571	ribonuclease III activity
GWP40_07415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP40_07420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP40_07435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP40_07465	COG1921	L-seryl-tRNASec selenium transferase activity
GWP40_07490	COG0574	Belongs to the PEP-utilizing enzyme family
GWP40_07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP40_07505	COG1230	cation diffusion facilitator family transporter
GWP40_07510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GWP40_07530	COG1725	Transcriptional regulator
GWP40_07535	COG1131	(ABC) transporter
GWP40_07550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWP40_07570	COG0455	bacterial-type flagellum organization
GWP40_07580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWP40_07585	COG0187	DNA topoisomerase II activity
GWP40_07610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP40_07615	COG0330	HflC and HflK could
GWP40_07620	COG0330	HflC and HflK could
GWP40_07675	COG1136	(ABC) transporter
GWP40_07680	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWP40_07690	COG0552	protein localization to endoplasmic reticulum
GWP40_07715	COG1122	ATPase activity
GWP40_07720	COG1268	BioY protein
GWP40_07730	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWP40_07735	COG1876	peptidase activity
GWP40_07765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP40_07770	COG0601	transmembrane transport
GWP40_07775	COG4608	Belongs to the ABC transporter superfamily
GWP40_07785	COG0561	phosphatase activity
GWP40_07790	COG0436	Aminotransferase
GWP40_07795	COG1522	sequence-specific DNA binding
GWP40_07810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP40_07815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP40_07835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_07850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP40_07865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP40_07870	COG2161	toxin-antitoxin pair type II binding
GWP40_07885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP40_07890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP40_07895	COG2604	Protein of unknown function DUF115
GWP40_07910	COG2186	Transcriptional regulator
GWP40_07915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWP40_07930	COG1070	Carbohydrate kinase
GWP40_07950	COG2388	GCN5-related N-acetyl-transferase
GWP40_07960	COG1309	transcriptional regulator
GWP40_07965	COG1620	l-lactate permease
GWP40_07970	COG4166	transmembrane transport
GWP40_07980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWP40_07990	COG0569	domain protein
GWP40_07995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWP40_08000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWP40_08035	COG0456	acetyltransferase
GWP40_08055	COG1373	ATPase (AAA superfamily
GWP40_08065	COG3142	Participates in the control of copper homeostasis
GWP40_08070	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP40_08115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWP40_08120	COG0785	Cytochrome C biogenesis protein
GWP40_08125	COG0583	DNA-binding transcription factor activity
GWP40_08150	COG1222	aaa ATPase
GWP40_08195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWP40_08215	COG1136	(ABC) transporter
GWP40_08220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWP40_08235	COG0357	Ribosomal RNA small subunit methyltransferase G
GWP40_08240	COG1301	dicarboxylic acid transport
GWP40_08255	COG0395	ABC-type sugar transport system, permease component
GWP40_08285	COG0228	four-way junction DNA binding
GWP40_08290	COG1837	Belongs to the UPF0109 family
GWP40_08295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWP40_08300	COG0336	Belongs to the RNA methyltransferase TrmD family
GWP40_08305	COG0335	large ribosomal subunit rRNA binding
GWP40_08315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP40_08445	COG1846	Transcriptional regulator
GWP40_08760	COG1115	amino acid carrier protein
GWP40_08795	COG0457	Tetratricopeptide repeat
GWP40_08800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWP40_08805	COG0733	neurotransmitter:sodium symporter activity
GWP40_08855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GWP40_08880	COG1509	lysine 2,3-aminomutase activity
GWP40_08885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP40_08910	COG1136	(ABC) transporter
GWP40_08955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWP40_08985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWP40_08990	COG1272	protein, Hemolysin III
GWP40_08995	COG0254	rRNA binding
GWP40_09000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWP40_09005	COG1546	Belongs to the CinA family
GWP40_09005	COG1058	Belongs to the CinA family
GWP40_09015	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP40_09020	COG0776	regulation of translation
GWP40_09025	COG0268	Binds directly to 16S ribosomal RNA
GWP40_09045	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWP40_09055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWP40_09065	COG0731	radical SAM domain protein
GWP40_09080	COG2201	protein-glutamate methylesterase activity
GWP40_09090	COG0835	chemotaxis
GWP40_09095	COG0643	Histidine kinase
GWP40_09095	COG2198	Histidine kinase
GWP40_09105	COG3118	belongs to the thioredoxin family
GWP40_09115	COG0617	tRNA 3'-terminal CCA addition
GWP40_09120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP40_09145	COG0563	adenylate kinase activity
GWP40_09170	COG2357	RelA SpoT domain protein
GWP40_09185	COG2375	cellular response to nickel ion
GWP40_09185	COG1132	(ABC) transporter
GWP40_09190	COG1309	transcriptional regulator
GWP40_09200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWP40_09225	COG0463	Glycosyl transferase, family 2
GWP40_09235	COG0534	Mate efflux family protein
GWP40_09240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWP40_09245	COG0482	sulfurtransferase activity
GWP40_09275	COG1196	nuclear chromosome segregation
GWP40_09285	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP40_09290	COG0724	RNA recognition motif
GWP40_09475	COG1131	(ABC) transporter
GWP40_09480	COG1309	transcriptional regulator
GWP40_09555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_09570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWP40_09575	COG0142	geranyltranstransferase activity
GWP40_09580	COG3579	cysteine-type endopeptidase activity
GWP40_09585	COG0475	glutathione-regulated potassium exporter activity
GWP40_09595	COG0758	DNA mediated transformation
GWP40_09605	COG4974	Belongs to the 'phage' integrase family
GWP40_09630	COG2604	Protein of unknown function DUF115
GWP40_09650	COG0525	valine-tRNA ligase activity
GWP40_09655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP40_09655	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_09665	COG1362	aminopeptidase activity
GWP40_09670	COG0557	exoribonuclease II activity
GWP40_09680	COG0534	Mate efflux family protein
GWP40_09690	COG1419	protein localization to endoplasmic reticulum
GWP40_09700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP40_09705	COG1684	flagellar biosynthetic protein fliR
GWP40_09710	COG1987	bacterial-type flagellum assembly
GWP40_09715	COG1338	Plays a role in the flagellum-specific transport system
GWP40_09725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP40_09725	COG1776	CheC inhibitor of MCP methylation
GWP40_09730	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP40_09735	COG1580	Controls the rotational direction of flagella during chemotaxis
GWP40_09745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWP40_09760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWP40_09770	COG1960	acyl-CoA dehydrogenase activity
GWP40_09790	COG0395	ABC-type sugar transport system, permease component
GWP40_09795	COG1175	transmembrane transport
GWP40_09805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWP40_09815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWP40_09820	COG0628	permease
GWP40_09825	COG0363	glucosamine-6-phosphate deaminase activity
GWP40_09830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWP40_09840	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWP40_09855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWP40_09860	COG1480	7TM receptor with intracellular HD hydrolase
GWP40_09875	COG0494	nUDIX hydrolase
GWP40_09880	COG1652	LysM domain
GWP40_09890	COG0735	belongs to the Fur family
GWP40_09900	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP40_09905	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP40_09910	COG1924	4 iron, 4 sulfur cluster binding
GWP40_09915	COG0786	glutamate:sodium symporter activity
GWP40_09920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWP40_09925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWP40_09930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWP40_09935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GWP40_09940	COG4770	biotin carboxylase activity
GWP40_09950	COG0786	glutamate:sodium symporter activity
GWP40_09955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP40_09960	COG0840	transmembrane signaling receptor activity
GWP40_09990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWP40_09995	COG0297	glycogen (starch) synthase activity
GWP40_10005	COG1598	PFAM Uncharacterised protein family UPF0150
GWP40_10010	COG1205	dead DEAH box helicase
GWP40_10010	COG1111	helicase
GWP40_10015	COG4115	mRNA cleavage
GWP40_10040	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWP40_10080	COG0405	Gamma-glutamyltransferase
GWP40_10095	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_10100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWP40_10130	COG1846	Transcriptional regulator
GWP40_10155	COG1715	Restriction endonuclease
GWP40_10185	COG4585	Histidine kinase
GWP40_10195	COG0483	inositol monophosphate 1-phosphatase activity
GWP40_10210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWP40_10210	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWP40_10210	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWP40_10210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWP40_10220	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP40_10265	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWP40_10280	COG0124	histidyl-tRNA synthetase
GWP40_10290	COG0116	Belongs to the methyltransferase superfamily
GWP40_10290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWP40_10295	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWP40_10315	COG0084	hydrolase, TatD family'
GWP40_10350	COG3588	fructose-bisphosphate aldolase
GWP40_10365	COG1979	alcohol dehydrogenase
GWP40_10380	COG1175	transmembrane transport
GWP40_10385	COG0395	ABC-type sugar transport system, permease component
GWP40_10420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWP40_10420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWP40_10425	COG3118	belongs to the thioredoxin family
GWP40_10430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWP40_10450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWP40_10470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWP40_10475	COG0484	heat shock protein binding
GWP40_10480	COG0528	UMP kinase activity
GWP40_10485	COG1305	Transglutaminase-like
GWP40_10500	COG0215	cysteine-tRNA ligase activity
GWP40_10505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWP40_10510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP40_10525	COG2201	protein-glutamate methylesterase activity
GWP40_10560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP40_10585	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWP40_10590	COG3041	Addiction module toxin RelE StbE family
GWP40_10615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP40_10625	COG0126	phosphoglycerate kinase activity
GWP40_10635	COG0813	purine-nucleoside phosphorylase activity
GWP40_10650	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWP40_10655	COG3639	organic phosphonate transmembrane transporter activity
GWP40_10675	COG1187	pseudouridine synthase activity
GWP40_10700	COG1129	ABC transporter
GWP40_10705	COG1609	Transcriptional regulator
GWP40_10715	COG0546	phosphoglycolate phosphatase activity
GWP40_10785	COG0756	dUTP diphosphatase activity
GWP40_10810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP40_10910	COG1253	flavin adenine dinucleotide binding
GWP40_10915	COG0840	transmembrane signaling receptor activity
GWP40_10930	COG0756	dUTP diphosphatase activity
GWP40_10935	COG1185	polyribonucleotide nucleotidyltransferase activity
GWP40_10955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP40_10960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWP40_10975	COG0779	Required for maturation of 30S ribosomal subunits
GWP40_10995	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWP40_10995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWP40_11005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWP40_11010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWP40_11020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWP40_11025	COG1047	Peptidyl-prolyl cis-trans
GWP40_11040	COG0251	oxidation-reduction process
GWP40_11070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWP40_11080	COG0556	nucleotide-excision repair
GWP40_11090	COG0556	nucleotide-excision repair
GWP40_11125	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWP40_11140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWP40_11210	COG2089	acid synthase
GWP40_11225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWP40_11245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_11280	COG2076	Multidrug Resistance protein
GWP40_11325	COG1373	ATPase (AAA superfamily
GWP40_11335	COG0028	Belongs to the TPP enzyme family
GWP40_11335	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
GWP40_11365	COG1362	aminopeptidase activity
GWP40_11370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP40_11390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWP40_11395	COG0017	Asparaginyl-tRNA synthetase
GWP40_11415	COG0701	Predicted permease
GWP40_11420	COG0116	Belongs to the methyltransferase superfamily
GWP40_11425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWP40_11430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP40_11435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP40_11445	COG0049	tRNA binding
GWP40_11460	COG0085	RNA polymerase activity
GWP40_11465	COG0222	ribosome binding
GWP40_11470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWP40_11480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWP40_11485	COG0250	Participates in transcription elongation, termination and antitermination
GWP40_11490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP40_11500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWP40_11515	COG1438	arginine binding
GWP40_11520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWP40_11535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWP40_11555	COG1254	Belongs to the acylphosphatase family
GWP40_11570	COG2217	Heavy metal translocating P-type atpase
GWP40_11595	COG1401	restriction endodeoxyribonuclease activity
GWP40_11635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWP40_11700	COG0616	signal peptide processing
GWP40_11705	COG4608	Belongs to the ABC transporter superfamily
GWP40_11710	COG0444	Belongs to the ABC transporter superfamily
GWP40_11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP40_11720	COG0601	transmembrane transport
GWP40_11730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWP40_11735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWP40_11740	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_11745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWP40_11755	COG1647	Serine aminopeptidase, S33
GWP40_11810	COG1309	transcriptional regulator
GWP40_11825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP40_11830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP40_11830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWP40_11840	COG0840	transmembrane signaling receptor activity
GWP40_11845	COG4443	Transcriptional Coactivator p15 (PC4)
GWP40_11850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWP40_11855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_11875	COG1475	DNA binding
GWP40_11880	COG1192	Involved in chromosome partitioning
GWP40_11885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWP40_11950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWP40_11970	COG1132	(ABC) transporter
GWP40_11970	COG2375	cellular response to nickel ion
GWP40_11975	COG1132	(ABC) transporter
GWP40_11995	COG3842	ATPase activity
GWP40_12000	COG1840	ABC-type Fe3 transport system, periplasmic component
GWP40_12005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GWP40_12015	COG2211	Major facilitator Superfamily
GWP40_12025	COG1132	(ABC) transporter
GWP40_12040	COG1132	(ABC) transporter
GWP40_12050	COG1132	(ABC) transporter
GWP40_12055	COG1132	(ABC) transporter
GWP40_12075	COG3550	peptidyl-serine autophosphorylation
GWP40_12085	COG1162	GTPase activity
GWP40_12105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWP40_12115	COG0826	peptidase U32
GWP40_12125	COG2207	Transcriptional regulator
GWP40_12130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWP40_12140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWP40_12145	COG0740	serine-type endopeptidase activity
GWP40_12150	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWP40_12190	COG0709	Synthesizes selenophosphate from selenide and ATP
GWP40_12195	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWP40_12205	COG4786	Flagellar basal body rod
GWP40_12255	COG1012	belongs to the aldehyde dehydrogenase family
GWP40_12260	COG1960	acyl-CoA dehydrogenase activity
GWP40_12330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWP40_12350	COG1191	sigma factor activity
GWP40_12365	COG0433	COG0433 Predicted ATPase
GWP40_12370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWP40_12380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWP40_12385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWP40_12395	COG0587	DNA-directed DNA polymerase activity
GWP40_12410	COG0217	transcriptional regulatory protein
GWP40_12425	COG0542	response to heat