locus-tag	class	description
E4N73_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N73_00030	COG1177	transmembrane transport
E4N73_00045	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4N73_00050	COG3842	ATPase activity
E4N73_00075	COG0019	diaminopimelate decarboxylase activity
E4N73_00080	COG0716	FMN binding
E4N73_00095	COG1956	GAF domain-containing protein
E4N73_00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N73_00110	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N73_00110	COG1136	(ABC) transporter
E4N73_00115	COG0577	efflux transmembrane transporter activity
E4N73_00115	COG1136	(ABC) transporter
E4N73_00140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N73_00155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N73_00155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N73_00165	COG0205	6-phosphofructokinase activity
E4N73_00170	COG0516	GMP reductase activity
E4N73_00180	COG1028	Short-chain dehydrogenase reductase Sdr
E4N73_00185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N73_00190	COG2204	response regulator
E4N73_00220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N73_00225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N73_00245	COG1686	Belongs to the peptidase S11 family
E4N73_00250	COG0739	heme binding
E4N73_00260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N73_00265	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N73_00290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N73_00310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N73_00315	COG0592	DNA-directed DNA polymerase activity
E4N73_00320	COG2089	acid synthase
E4N73_00415	COG1757	Na H antiporter
E4N73_00420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N73_00425	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N73_00475	COG4373	Mu-like prophage FluMu protein gp28
E4N73_00560	COG3409	Peptidoglycan-binding domain 1 protein
E4N73_00560	COG3267	Type II secretory pathway component ExeA
E4N73_00585	COG4397	Mu-like prophage major head subunit gpT
E4N73_00695	COG1129	ABC transporter
E4N73_00725	COG1309	transcriptional regulator
E4N73_00740	COG1129	ABC transporter
E4N73_00775	COG3340	Belongs to the peptidase S51 family
E4N73_00795	COG2226	methyltransferase
E4N73_00805	COG1309	transcriptional regulator
E4N73_00885	COG4585	Histidine kinase
E4N73_00935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N73_00980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N73_00985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N73_00990	COG1028	Short-chain dehydrogenase reductase Sdr
E4N73_01000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N73_01025	COG2986	histidine ammonia-lyase
E4N73_01030	COG3041	Addiction module toxin RelE StbE family
E4N73_01055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N73_01060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N73_01065	COG0204	Acyl-transferase
E4N73_01065	COG0318	PFAM AMP-dependent synthetase and ligase
E4N73_01105	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4N73_01115	COG4656	Part of a membrane complex involved in electron transport
E4N73_01150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N73_01170	COG1131	(ABC) transporter
E4N73_01175	COG0778	Nitroreductase
E4N73_01185	COG0822	iron-sulfur transferase activity
E4N73_01195	COG0826	peptidase U32
E4N73_01220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N73_01225	COG0051	transcription antitermination factor activity, RNA binding
E4N73_01230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N73_01235	COG0088	Forms part of the polypeptide exit tunnel
E4N73_01240	COG0089	rRNA binding
E4N73_01245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N73_01255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N73_01260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N73_01270	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N73_01275	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N73_01280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N73_01285	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N73_01290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N73_01300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N73_01305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N73_01310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N73_01315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N73_01325	COG0200	Binds to the 23S rRNA
E4N73_01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N73_01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N73_01350	COG0202	RNA polymerase activity
E4N73_01355	COG0203	ribosomal protein L17
E4N73_01370	COG2239	Acts as a magnesium transporter
E4N73_01375	COG0170	dolichyl monophosphate biosynthetic process
E4N73_01385	COG2252	PERMEase
E4N73_01410	COG0511	ligase activity, forming carbon-carbon bonds
E4N73_01410	COG5016	pyruvate
E4N73_01420	COG0543	2 iron, 2 sulfur cluster binding
E4N73_01425	COG1639	'signal transduction protein
E4N73_01430	COG1121	(ABC) transporter
E4N73_01445	COG1151	hydroxylamine reductase activity
E4N73_01455	COG1115	amino acid carrier protein
E4N73_01470	COG1609	Transcriptional regulator
E4N73_01485	COG0395	ABC-type sugar transport system, permease component
E4N73_01495	COG3250	beta-galactosidase activity
E4N73_01505	COG0395	ABC-type sugar transport system, permease component
E4N73_01510	COG1175	transmembrane transport
E4N73_01520	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N73_01535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N73_01545	COG2011	ABC-type metal ion transport system permease component
E4N73_01550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N73_01555	COG0681	Belongs to the peptidase S26 family
E4N73_01560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N73_01570	COG1199	ATP-dependent helicase activity
E4N73_01585	COG3041	Addiction module toxin RelE StbE family
E4N73_01645	COG4443	Transcriptional Coactivator p15 (PC4)
E4N73_01650	COG0840	transmembrane signaling receptor activity
E4N73_01665	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N73_01670	COG3437	response regulator, receiver
E4N73_01675	COG1671	Belongs to the UPF0178 family
E4N73_01680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N73_01695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N73_01710	COG0513	Belongs to the DEAD box helicase family
E4N73_01715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N73_01720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N73_01725	COG1028	Short-chain dehydrogenase reductase Sdr
E4N73_01730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N73_01735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N73_01740	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N73_01755	COG0728	peptidoglycan biosynthetic process
E4N73_01785	COG1193	negative regulation of DNA recombination
E4N73_01795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N73_01800	COG0733	neurotransmitter:sodium symporter activity
E4N73_01815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N73_01830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N73_01840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N73_01840	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N73_01845	COG1640	4-alpha-glucanotransferase
E4N73_01850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N73_01910	COG1983	PspC domain protein
E4N73_01920	COG1695	Transcriptional regulator
E4N73_01935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N73_01945	COG0445	tRNA wobble uridine modification
E4N73_01955	COG2255	four-way junction helicase activity
E4N73_01965	COG1722	exodeoxyribonuclease VII activity
E4N73_01970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N73_01975	COG0433	COG0433 Predicted ATPase
E4N73_01985	COG1191	sigma factor activity
E4N73_02055	COG1484	DNA-dependent DNA replication
E4N73_02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N73_02140	COG2003	Belongs to the UPF0758 family
E4N73_02210	COG2948	multi-organism process
E4N73_02215	COG3504	Conjugal transfer protein
E4N73_02235	COG3451	type IV secretory pathway VirB4
E4N73_02260	COG4962	Type ii secretion system protein e
E4N73_02280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N73_02280	COG0551	DNA topoisomerase type I activity
E4N73_02320	COG1414	Transcriptional regulator
E4N73_02330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N73_02340	COG0450	alkyl hydroperoxide reductase
E4N73_02350	COG0617	tRNA 3'-terminal CCA addition
E4N73_02365	COG1027	Aspartate ammonia-lyase
E4N73_02370	COG0295	cytidine deaminase activity
E4N73_02380	COG0739	heme binding
E4N73_02410	COG0746	molybdenum cofactor guanylyltransferase activity
E4N73_02415	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N73_02420	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N73_02425	COG1129	ABC transporter
E4N73_02430	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N73_02435	COG1254	Belongs to the acylphosphatase family
E4N73_02445	COG0351	phosphomethylpyrimidine kinase
E4N73_02455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N73_02455	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N73_02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N73_02485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N73_02490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N73_02490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N73_02490	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N73_02490	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N73_02520	COG1196	nuclear chromosome segregation
E4N73_02555	COG1129	ABC transporter
E4N73_02595	COG2801	Transposase and inactivated derivatives
E4N73_02660	COG4221	oxidoreductase activity
E4N73_02660	COG3321	synthase
E4N73_02660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4N73_02660	COG0604	alcohol dehydrogenase
E4N73_02665	COG0535	radical SAM domain protein
E4N73_02675	COG1733	regulation of RNA biosynthetic process
E4N73_02710	COG1881	PFAM PEBP family protein
E4N73_02720	COG0346	lactoylglutathione lyase activity
E4N73_02725	COG0542	response to heat
E4N73_02735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N73_02740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4N73_02745	COG1914	H( )-stimulated, divalent metal cation uptake system
E4N73_02750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4N73_02755	COG1984	allophanate hydrolase subunit 2
E4N73_02765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N73_02770	COG0443	Heat shock 70 kDa protein
E4N73_02775	COG0484	heat shock protein binding
E4N73_02810	COG0513	Belongs to the DEAD box helicase family
E4N73_02820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N73_02830	COG0613	PHP domain protein
E4N73_02835	COG0670	Belongs to the BI1 family
E4N73_02850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4N73_02860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N73_02895	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
E4N73_02895	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N73_02905	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N73_02920	COG3052	prosthetic group binding
E4N73_02925	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N73_02945	COG0793	Belongs to the peptidase S41A family
E4N73_02965	COG3876	Protein conserved in bacteria
E4N73_03000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N73_03005	COG0706	membrane insertase activity
E4N73_03010	COG1847	R3H domain protein
E4N73_03020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N73_03025	COG1862	Preprotein translocase
E4N73_03030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N73_03035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N73_03050	COG1362	aminopeptidase activity
E4N73_03055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N73_03060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N73_03090	COG4115	mRNA cleavage
E4N73_03095	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N73_03100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N73_03105	COG0457	Tetratricopeptide repeat
E4N73_03110	COG0733	neurotransmitter:sodium symporter activity
E4N73_03115	COG0180	Tryptophanyl-tRNA synthetase
E4N73_03140	COG0406	alpha-ribazole phosphatase activity
E4N73_03160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N73_03185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N73_03190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N73_03195	COG1570	exodeoxyribonuclease VII activity
E4N73_03205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N73_03230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N73_03245	COG0534	Mate efflux family protein
E4N73_03265	COG1102	Psort location Cytoplasmic, score
E4N73_03295	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N73_03300	COG3845	ABC transporter
E4N73_03305	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N73_03310	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N73_03320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N73_03325	COG1609	Transcriptional regulator
E4N73_03330	COG1966	Carbon starvation protein
E4N73_03335	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N73_03350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N73_03360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4N73_03380	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N73_03385	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N73_03390	COG3845	ABC transporter
E4N73_03395	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N73_03415	COG0709	Synthesizes selenophosphate from selenide and ATP
E4N73_03420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N73_03490	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N73_03495	COG0419	ATPase involved in DNA repair
E4N73_03505	COG1309	transcriptional regulator
E4N73_03510	COG3848	Pyruvate phosphate dikinase
E4N73_03510	COG0574	Belongs to the PEP-utilizing enzyme family
E4N73_03520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N73_03535	COG1396	sequence-specific DNA binding
E4N73_03535	COG3800	Transcriptional regulator
E4N73_03560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N73_03565	COG0779	Required for maturation of 30S ribosomal subunits
E4N73_03575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N73_03580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N73_03590	COG0196	riboflavin kinase activity
E4N73_03600	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N73_03605	COG0756	dUTP diphosphatase activity
E4N73_03625	COG0557	exoribonuclease II activity
E4N73_03640	COG1362	aminopeptidase activity
E4N73_03650	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N73_03650	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N73_03660	COG1247	-acetyltransferase
E4N73_03665	COG0698	ribose 5-phosphate isomerase
E4N73_03675	COG1132	(ABC) transporter
E4N73_03675	COG2375	cellular response to nickel ion
E4N73_03680	COG1132	(ABC) transporter
E4N73_03705	COG2226	methyltransferase
E4N73_03765	COG1725	Transcriptional regulator
E4N73_03770	COG1131	(ABC) transporter
E4N73_03780	COG1373	ATPase (AAA superfamily
E4N73_03790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N73_03805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N73_03810	COG1360	Flagellar Motor Protein
E4N73_03815	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N73_03820	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N73_03825	COG1776	CheC inhibitor of MCP methylation
E4N73_03825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N73_03835	COG1338	Plays a role in the flagellum-specific transport system
E4N73_03840	COG1987	bacterial-type flagellum assembly
E4N73_03845	COG1684	flagellar biosynthetic protein fliR
E4N73_03850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N73_03855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N73_03860	COG1419	protein localization to endoplasmic reticulum
E4N73_03870	COG1215	transferase activity, transferring glycosyl groups
E4N73_03875	COG0534	Mate efflux family protein
E4N73_03885	COG0826	peptidase U32
E4N73_03895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N73_03905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N73_03920	COG2226	methyltransferase
E4N73_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N73_03945	COG1120	ATPase activity
E4N73_03960	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N73_03970	COG4786	Flagellar basal body rod
E4N73_03975	COG1061	Type III restriction enzyme res subunit
E4N73_03980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N73_03985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N73_03990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N73_04000	COG1774	PSP1 C-terminal conserved region
E4N73_04015	COG0739	heme binding
E4N73_04025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N73_04030	COG2911	Protein conserved in bacteria
E4N73_04035	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N73_04045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N73_04060	COG0739	heme binding
E4N73_04060	COG0741	lytic transglycosylase activity
E4N73_04060	COG1196	nuclear chromosome segregation
E4N73_04075	COG2502	aspartate--ammonia ligase
E4N73_04085	COG0301	tRNA thio-modification
E4N73_04100	COG1879	ABC-type sugar transport system periplasmic component
E4N73_04105	COG1129	ABC transporter
E4N73_04110	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N73_04115	COG0348	domain, Protein
E4N73_04120	COG0427	acetyl-CoA hydrolase
E4N73_04125	COG1024	Enoyl-CoA hydratase
E4N73_04130	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4N73_04135	COG1253	flavin adenine dinucleotide binding
E4N73_04150	COG0840	transmembrane signaling receptor activity
E4N73_04150	COG3290	protein histidine kinase activity
E4N73_04165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N73_04165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N73_04175	COG0481	GTPase activity
E4N73_04190	COG0525	valine-tRNA ligase activity
E4N73_04210	COG2604	Protein of unknown function DUF115
E4N73_04240	COG4974	Belongs to the 'phage' integrase family
E4N73_04245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N73_04245	COG0551	DNA topoisomerase type I activity
E4N73_04250	COG0758	DNA mediated transformation
E4N73_04280	COG0719	Fe-S assembly protein
E4N73_04290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N73_04295	COG1692	metallophosphoesterase
E4N73_04300	COG3118	belongs to the thioredoxin family
E4N73_04310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N73_04320	COG1288	antiporter activity
E4N73_04325	COG0549	Belongs to the carbamate kinase family
E4N73_04330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N73_04335	COG2235	arginine
E4N73_04340	COG0018	arginyl-trna synthetase
E4N73_04355	COG2207	Transcriptional regulator
E4N73_04355	COG3708	Transcriptional regulator
E4N73_04365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N73_04375	COG1175	transmembrane transport
E4N73_04380	COG0395	ABC-type sugar transport system, permease component
E4N73_04395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N73_04400	COG0672	)-iron permease
E4N73_04405	COG3470	protein probably involved in high-affinity Fe2 transport
E4N73_04420	COG0577	efflux transmembrane transporter activity
E4N73_04420	COG1136	(ABC) transporter
E4N73_04425	COG1136	(ABC) transporter
E4N73_04430	COG1373	ATPase (AAA superfamily
E4N73_04510	COG3842	ATPase activity
E4N73_04515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N73_04520	COG4988	ABC transporter
E4N73_04525	COG1132	(ABC) transporter
E4N73_04530	COG0840	transmembrane signaling receptor activity
E4N73_04545	COG0546	phosphoglycolate phosphatase activity
E4N73_04555	COG1187	pseudouridine synthase activity
E4N73_04570	COG3639	organic phosphonate transmembrane transporter activity
E4N73_04575	COG3639	organic phosphonate transmembrane transporter activity
E4N73_04580	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N73_04595	COG0813	purine-nucleoside phosphorylase activity
E4N73_04640	COG0546	phosphoglycolate phosphatase activity
E4N73_04645	COG0668	transmembrane transport
E4N73_04655	COG0210	DNA helicase
E4N73_04665	COG0732	type I restriction modification DNA specificity domain
E4N73_04690	COG3177	Filamentation induced by cAMP protein fic
E4N73_04695	COG4974	Belongs to the 'phage' integrase family
E4N73_04720	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4N73_04755	COG0297	glycogen (starch) synthase activity
E4N73_04770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N73_04780	COG0564	pseudouridine synthase activity
E4N73_04785	COG0802	atpase or kinase
E4N73_04790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N73_04795	COG2770	Histidine kinase
E4N73_04795	COG3437	response regulator, receiver
E4N73_04810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N73_04825	COG1760	l-serine dehydratase
E4N73_04830	COG1760	l-serine dehydratase
E4N73_04835	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4N73_04870	COG1647	Serine aminopeptidase, S33
E4N73_04875	COG0405	Gamma-glutamyltransferase
E4N73_04915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N73_04920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N73_04935	COG0058	SHG alpha-glucan phosphorylase activity
E4N73_04945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N73_04955	COG1040	competence protein
E4N73_04965	COG1373	ATPase (AAA superfamily
E4N73_04985	COG1086	Polysaccharide biosynthesis protein
E4N73_05000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4N73_05035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N73_05045	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4N73_05050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N73_05065	COG1086	Polysaccharide biosynthesis protein
E4N73_05130	COG0577	efflux transmembrane transporter activity
E4N73_05130	COG1136	(ABC) transporter
E4N73_05135	COG0577	efflux transmembrane transporter activity
E4N73_05135	COG1136	(ABC) transporter
E4N73_05140	COG1136	(ABC) transporter
E4N73_05155	COG2226	methyltransferase
E4N73_05160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N73_05175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N73_05205	COG1413	lyase activity
E4N73_05210	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N73_05215	COG0116	Belongs to the methyltransferase superfamily
E4N73_05215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4N73_05225	COG0343	queuine tRNA-ribosyltransferase activity
E4N73_05265	COG2358	TRAP transporter, solute receptor (TAXI family
E4N73_05275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N73_05295	COG0534	Mate efflux family protein
E4N73_05310	COG0495	leucyl-tRNA aminoacylation
E4N73_05345	COG0335	large ribosomal subunit rRNA binding
E4N73_05350	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N73_05355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N73_05360	COG1837	Belongs to the UPF0109 family
E4N73_05365	COG0228	four-way junction DNA binding
E4N73_05370	COG1321	iron dependent repressor
E4N73_05455	COG2373	Large extracellular alpha-helical protein
E4N73_05470	COG3330	Domain of unknown function (DUF4912)
E4N73_05480	COG0588	phosphoglycerate mutase activity
E4N73_05485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N73_05535	COG4373	Mu-like prophage FluMu protein gp28
E4N73_05625	COG3409	Peptidoglycan-binding domain 1 protein
E4N73_05625	COG3267	Type II secretory pathway component ExeA
E4N73_05650	COG4397	Mu-like prophage major head subunit gpT
E4N73_05750	COG4953	penicillin-binding protein 1C
E4N73_05765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N73_05815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N73_05820	COG3681	Belongs to the UPF0597 family
E4N73_05835	COG1704	LemA family
E4N73_05840	COG0424	maF-like protein
E4N73_05845	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N73_05850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N73_05855	COG0233	cytoplasmic translational termination
E4N73_05860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N73_05865	COG0575	Belongs to the CDS family
E4N73_05870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N73_05875	COG0750	zinc metalloprotease
E4N73_05890	COG1309	transcriptional regulator
E4N73_05900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N73_05925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N73_05930	COG0714	Associated with various cellular activities
E4N73_05935	COG3421	Type III restriction
E4N73_05940	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N73_05945	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N73_05950	COG3620	sequence-specific DNA binding
E4N73_05955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N73_05970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N73_05975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N73_05980	COG1192	Involved in chromosome partitioning
E4N73_05985	COG1475	DNA binding
E4N73_06010	COG1418	mRNA catabolic process
E4N73_06015	COG1487	ribonuclease activity
E4N73_06040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N73_06050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4N73_06060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N73_06065	COG1438	arginine binding
E4N73_06075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N73_06090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N73_06095	COG2233	PERMEase
E4N73_06130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4N73_06150	COG0149	triose-phosphate isomerase activity
E4N73_06155	COG2885	chlorophyll binding
E4N73_06160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N73_06180	COG0542	response to heat
E4N73_06185	COG1683	Conserved Protein
E4N73_06190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N73_06195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N73_06200	COG1121	(ABC) transporter
E4N73_06230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N73_06235	COG0358	DNA primase activity
E4N73_06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N73_06260	COG1077	Cell shape determining protein MreB Mrl
E4N73_06275	COG0768	penicillin binding
E4N73_06280	COG0772	Belongs to the SEDS family
E4N73_06290	COG0563	adenylate kinase activity
E4N73_06295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N73_06310	COG2357	RelA SpoT domain protein
E4N73_06325	COG1132	(ABC) transporter
E4N73_06325	COG2375	cellular response to nickel ion
E4N73_06345	COG1846	Transcriptional regulator
E4N73_06365	COG1301	dicarboxylic acid transport
E4N73_06385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N73_06390	COG0617	tRNA 3'-terminal CCA addition
E4N73_06395	COG1523	belongs to the glycosyl hydrolase 13 family
E4N73_06400	COG2182	Extracellular solute-binding protein
E4N73_06415	COG1175	transmembrane transport
E4N73_06420	COG3833	ABC-type maltose transport systems, permease component
E4N73_06430	COG3118	belongs to the thioredoxin family
E4N73_06440	COG0643	Histidine kinase
E4N73_06440	COG2198	Histidine kinase
E4N73_06445	COG0835	chemotaxis
E4N73_06455	COG2201	protein-glutamate methylesterase activity
E4N73_06470	COG0731	radical SAM domain protein
E4N73_06480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N73_06485	COG0151	Belongs to the GarS family
E4N73_06490	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N73_06510	COG0268	Binds directly to 16S ribosomal RNA
E4N73_06520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N73_06530	COG1546	Belongs to the CinA family
E4N73_06530	COG1058	Belongs to the CinA family
E4N73_06535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N73_06540	COG0254	rRNA binding
E4N73_06545	COG1272	protein, Hemolysin III
E4N73_06550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N73_06580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N73_06590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4N73_06595	COG0569	domain protein
E4N73_06605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4N73_06625	COG0840	transmembrane signaling receptor activity
E4N73_06630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N73_06635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N73_06640	COG0142	geranyltranstransferase activity
E4N73_06670	COG1129	ABC transporter
E4N73_06680	COG1132	(ABC) transporter
E4N73_06685	COG1132	(ABC) transporter
E4N73_06690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N73_06695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N73_06695	COG0426	domain, Protein
E4N73_06710	COG2003	Belongs to the UPF0758 family
E4N73_06730	COG3549	Plasmid maintenance system killer
E4N73_06740	COG1131	(ABC) transporter
E4N73_06745	COG1309	transcriptional regulator
E4N73_06760	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N73_06765	COG3876	Protein conserved in bacteria
E4N73_06775	COG2885	chlorophyll binding
E4N73_06780	COG0741	lytic transglycosylase activity
E4N73_06780	COG1388	LysM domain
E4N73_06810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4N73_06830	COG2604	Protein of unknown function DUF115
E4N73_06835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N73_06845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N73_06865	COG0724	RNA recognition motif
E4N73_06870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N73_06880	COG1196	nuclear chromosome segregation
E4N73_06885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N73_06890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N73_06905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N73_06910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N73_06950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N73_06960	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4N73_06965	COG3657	addiction module killer protein
E4N73_06970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N73_06980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N73_06995	COG0504	CTP synthase activity
E4N73_07020	COG0482	sulfurtransferase activity
E4N73_07035	COG2388	GCN5-related N-acetyl-transferase
E4N73_07060	COG1104	cysteine desulfurase activity
E4N73_07065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N73_07085	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N73_07090	COG0629	single-stranded DNA binding
E4N73_07095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N73_07100	COG0359	binds to the 23S rRNA
E4N73_07105	COG0305	Participates in initiation and elongation during chromosome replication
E4N73_07125	COG0470	DNA polymerase III
E4N73_07135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N73_07155	COG1122	ATPase activity
E4N73_07160	COG1268	BioY protein
E4N73_07170	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N73_07205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N73_07210	COG0601	transmembrane transport
E4N73_07215	COG4608	Belongs to the ABC transporter superfamily
E4N73_07225	COG0561	phosphatase activity
E4N73_07230	COG0436	Aminotransferase
E4N73_07235	COG1522	sequence-specific DNA binding
E4N73_07240	COG0534	Mate efflux family protein
E4N73_07245	COG0523	cobalamin synthesis protein
E4N73_07250	COG0101	tRNA pseudouridine synthase activity
E4N73_07260	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N73_07270	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N73_07275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4N73_07280	COG0519	Catalyzes the synthesis of GMP from XMP
E4N73_07295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N73_07310	COG0583	DNA-binding transcription factor activity
E4N73_07315	COG0785	Cytochrome C biogenesis protein
E4N73_07320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N73_07330	COG0666	response to abiotic stimulus
E4N73_07335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N73_07340	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N73_07345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4N73_07365	COG1136	(ABC) transporter
E4N73_07370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N73_07375	COG0193	aminoacyl-tRNA hydrolase activity
E4N73_07385	COG0823	Involved in the tonB-independent uptake of proteins
E4N73_07390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N73_07395	COG2208	phosphoserine phosphatase activity
E4N73_07410	COG0708	Exodeoxyribonuclease III
E4N73_07420	COG2832	Protein of unknown function (DUF454)
E4N73_07425	COG1137	ATPase activity
E4N73_07440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N73_07440	COG0493	'glutamate synthase
E4N73_07445	COG0402	S-adenosylhomocysteine deaminase activity
E4N73_07465	COG1120	ATPase activity
E4N73_07470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N73_07480	COG1509	lysine 2,3-aminomutase activity
E4N73_07485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N73_07510	COG1234	tRNA 3'-trailer cleavage
E4N73_07520	COG4254	PFAM FecR protein
E4N73_07530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N73_07535	COG0154	amidase activity
E4N73_07540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N73_07550	COG2211	Major facilitator Superfamily
E4N73_07570	COG0835	chemotaxis
E4N73_07575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N73_07580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N73_07585	COG0497	DNA recombination
E4N73_07605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4N73_07610	COG0363	glucosamine-6-phosphate deaminase activity
E4N73_07615	COG0628	permease
E4N73_07620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N73_07625	COG0328	RNA-DNA hybrid ribonuclease activity
E4N73_07635	COG3852	Histidine kinase
E4N73_07640	COG2204	response regulator
E4N73_07660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N73_07665	COG2971	BadF BadG BcrA BcrD
E4N73_07670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4N73_07685	COG1175	transmembrane transport
E4N73_07690	COG0395	ABC-type sugar transport system, permease component
E4N73_07700	COG1067	ATP-dependent peptidase activity
E4N73_07710	COG0456	acetyltransferase
E4N73_07750	COG3620	sequence-specific DNA binding
E4N73_07760	COG0187	DNA topoisomerase II activity
E4N73_07765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N73_07780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N73_07785	COG0166	Belongs to the GPI family
E4N73_07790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N73_07795	COG4115	mRNA cleavage
E4N73_07810	COG3579	cysteine-type endopeptidase activity
E4N73_07815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N73_07820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N73_07840	COG1766	The M ring may be actively involved in energy transduction
E4N73_07850	COG1317	bacterial-type flagellum organization
E4N73_07855	COG1157	protein secretion by the type III secretion system
E4N73_07865	COG1960	acyl-CoA dehydrogenase activity
E4N73_07880	COG0742	ribosomal rna small subunit methyltransferase
E4N73_07895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N73_07900	COG0840	transmembrane signaling receptor activity
E4N73_07905	COG0571	ribonuclease III activity
E4N73_07910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N73_07915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N73_07940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N73_07940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N73_07945	COG3118	belongs to the thioredoxin family
E4N73_07950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N73_07970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N73_07990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N73_07995	COG0484	heat shock protein binding
E4N73_08000	COG0528	UMP kinase activity
E4N73_08005	COG1305	Transglutaminase-like
E4N73_08020	COG0215	cysteine-tRNA ligase activity
E4N73_08025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N73_08030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N73_08045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N73_08045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N73_08045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N73_08055	COG3842	ATPase activity
E4N73_08090	COG1136	(ABC) transporter
E4N73_08095	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N73_08105	COG0552	protein localization to endoplasmic reticulum
E4N73_08135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N73_08145	COG4166	transmembrane transport
E4N73_08150	COG1620	l-lactate permease
E4N73_08170	COG0475	glutathione-regulated potassium exporter activity
E4N73_08175	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4N73_08180	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N73_08185	COG3842	ATPase activity
E4N73_08195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N73_08200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N73_08205	COG0457	Tetratricopeptide repeat
E4N73_08210	COG0037	tRNA processing
E4N73_08215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N73_08225	COG2088	sporulation resulting in formation of a cellular spore
E4N73_08230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N73_08235	COG0537	adenosine 5'-monophosphoramidase activity
E4N73_08240	COG0840	transmembrane signaling receptor activity
E4N73_08260	COG1115	amino acid carrier protein
E4N73_08265	COG2066	Belongs to the glutaminase family
E4N73_08270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N73_08285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N73_08290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N73_08305	COG3290	protein histidine kinase activity
E4N73_08305	COG3829	transcription factor binding
E4N73_08340	COG0427	acetyl-CoA hydrolase
E4N73_08345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N73_08350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N73_08365	COG3142	Participates in the control of copper homeostasis
E4N73_08395	COG2066	Belongs to the glutaminase family
E4N73_08405	COG3956	TIGRFAM MazG family protein
E4N73_08410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N73_08430	COG3209	COG3209 Rhs family protein
E4N73_08465	COG1450	Type ii and iii secretion system protein
E4N73_08485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N73_08485	COG1747	RNA polymerase binding
E4N73_08510	COG1482	cell wall glycoprotein biosynthetic process
E4N73_08515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N73_08520	COG1573	uracil-dna glycosylase
E4N73_08575	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4N73_08585	COG1401	restriction endodeoxyribonuclease activity
E4N73_08600	COG0574	Belongs to the PEP-utilizing enzyme family
E4N73_08600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N73_08605	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N73_08610	COG0318	PFAM AMP-dependent synthetase and ligase
E4N73_08645	COG4209	transmembrane transport
E4N73_08650	COG0395	ABC-type sugar transport system, permease component
E4N73_08665	COG2201	protein-glutamate methylesterase activity
E4N73_08710	COG0126	phosphoglycerate kinase activity
E4N73_08740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N73_08745	COG1480	7TM receptor with intracellular HD hydrolase
E4N73_08760	COG0494	nUDIX hydrolase
E4N73_08775	COG0735	belongs to the Fur family
E4N73_08785	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N73_08790	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N73_08795	COG1924	4 iron, 4 sulfur cluster binding
E4N73_08800	COG0786	glutamate:sodium symporter activity
E4N73_08805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4N73_08810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4N73_08815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4N73_08820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4N73_08825	COG0511	ligase activity, forming carbon-carbon bonds
E4N73_08835	COG0786	glutamate:sodium symporter activity
E4N73_08840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N73_08845	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N73_08865	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N73_08870	COG0205	6-phosphofructokinase activity
E4N73_08875	COG0285	dihydrofolate synthase activity
E4N73_08880	COG0564	pseudouridine synthase activity
E4N73_08920	COG0330	HflC and HflK could
E4N73_08925	COG0330	HflC and HflK could
E4N73_08945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N73_08950	COG4771	TonB-dependent receptor
E4N73_08990	COG0848	biopolymer transport protein
E4N73_08995	COG0811	peptide transport
E4N73_09005	COG0455	bacterial-type flagellum organization
E4N73_09015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N73_09025	COG0737	Belongs to the 5'-nucleotidase family
E4N73_09035	COG0514	ATP-dependent DNA helicase (RecQ)
E4N73_09055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N73_09065	COG0322	excinuclease ABC activity
E4N73_09080	COG2001	Belongs to the MraZ family
E4N73_09085	COG0275	rRNA processing
E4N73_09095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N73_09100	COG0772	Belongs to the SEDS family
E4N73_09105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4N73_09115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N73_09155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N73_09165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N73_09170	COG0574	Belongs to the PEP-utilizing enzyme family
E4N73_09170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N73_09185	COG2304	oxidoreductase activity
E4N73_09195	COG0183	Belongs to the thiolase family
E4N73_09200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N73_09205	COG0297	glycogen (starch) synthase activity
E4N73_09210	COG1022	Amp-dependent synthetase and ligase
E4N73_09215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N73_09235	COG3189	MarR family transcriptional regulator
E4N73_09245	COG0442	prolyl-tRNA aminoacylation
E4N73_09250	COG5341	Protein conserved in bacteria
E4N73_09260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N73_09285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N73_09285	COG3116	cell division
E4N73_09290	COG0084	hydrolase, TatD family'
E4N73_09310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N73_09325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N73_09330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N73_09335	COG1739	Uncharacterized protein family UPF0029
E4N73_09340	COG0632	four-way junction helicase activity
E4N73_09415	COG4166	transmembrane transport
E4N73_09420	COG0601	transmembrane transport
E4N73_09425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N73_09430	COG0444	Belongs to the ABC transporter superfamily
E4N73_09435	COG4608	Belongs to the ABC transporter superfamily
E4N73_09450	COG0616	signal peptide processing
E4N73_09470	COG1595	DNA-templated transcription, initiation
E4N73_09495	COG1129	ABC transporter
E4N73_09515	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N73_09525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N73_09545	COG1129	ABC transporter
E4N73_09550	COG1609	Transcriptional regulator
E4N73_09570	COG0791	NLP P60 protein
E4N73_09575	COG0318	PFAM AMP-dependent synthetase and ligase
E4N73_09585	COG0577	efflux transmembrane transporter activity
E4N73_09585	COG1136	(ABC) transporter
E4N73_09595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N73_09605	COG1464	Belongs to the NlpA lipoprotein family
E4N73_09620	COG1477	protein flavinylation
E4N73_09630	COG3588	fructose-bisphosphate aldolase
E4N73_09645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4N73_09650	COG0488	(ABC) transporter
E4N73_09675	COG0457	Tetratricopeptide repeat
E4N73_09680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N73_09685	COG0733	neurotransmitter:sodium symporter activity
E4N73_09690	COG0217	transcriptional regulatory protein
E4N73_09700	COG1979	alcohol dehydrogenase
E4N73_09705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N73_09710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N73_09730	COG0049	tRNA binding
E4N73_09745	COG0085	RNA polymerase activity
E4N73_09750	COG0222	ribosome binding
E4N73_09755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N73_09760	COG0081	regulation of translation
E4N73_09765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N73_09770	COG0250	Participates in transcription elongation, termination and antitermination
E4N73_09775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N73_09785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N73_09805	COG0762	integral membrane protein
E4N73_09810	COG0010	Belongs to the arginase family
E4N73_09815	COG1914	H( )-stimulated, divalent metal cation uptake system
E4N73_09830	COG0587	DNA-directed DNA polymerase activity
E4N73_09835	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N73_09845	COG0740	serine-type endopeptidase activity
E4N73_09855	COG0681	Belongs to the peptidase S26 family
E4N73_09860	COG0840	transmembrane signaling receptor activity
E4N73_09895	COG0300	oxidoreductase activity
E4N73_09910	COG1288	antiporter activity
E4N73_09915	COG2887	Belongs to the helicase family. UvrD subfamily
E4N73_09960	COG1960	acyl-CoA dehydrogenase activity
E4N73_09965	COG1012	belongs to the aldehyde dehydrogenase family
E4N73_09985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N73_09995	COG0556	nucleotide-excision repair
E4N73_10010	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4N73_10010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4N73_10020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N73_10025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N73_10035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N73_10050	COG0037	tRNA processing
E4N73_10070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N73_10095	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N73_10105	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N73_10110	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N73_10115	COG1394	ATPase activity, coupled to movement of substances
E4N73_10120	COG1269	ATP hydrolysis coupled proton transport
E4N73_10170	COG0251	oxidation-reduction process
E4N73_10185	COG1047	Peptidyl-prolyl cis-trans
E4N73_10195	COG4149	molybdate abc transporter
E4N73_10200	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4N73_10205	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4N73_10235	COG1924	4 iron, 4 sulfur cluster binding
E4N73_10250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N73_10260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N73_10295	COG0017	Asparaginyl-tRNA synthetase
E4N73_10300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N73_10305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N73_10320	COG1129	ABC transporter
E4N73_10335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N73_10340	COG3706	GGDEF domain
E4N73_10340	COG4251	negative regulation of phosphorylation
E4N73_10340	COG5001	Diguanylate cyclase
E4N73_10340	COG2203	Gaf domain
E4N73_10345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N73_10350	COG0205	6-phosphofructokinase activity
E4N73_10365	COG0124	histidyl-tRNA synthetase
E4N73_10375	COG2204	response regulator
E4N73_10380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N73_10390	COG0840	transmembrane signaling receptor activity
E4N73_10395	COG0840	transmembrane signaling receptor activity
E4N73_10415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N73_10430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N73_10445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N73_10450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N73_10455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N73_10460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N73_10465	COG2878	Part of a membrane complex involved in electron transport
E4N73_10470	COG4657	Part of a membrane complex involved in electron transport
E4N73_10475	COG4660	Part of a membrane complex involved in electron transport
E4N73_10480	COG4659	FMN binding
E4N73_10485	COG4658	electron transport chain
E4N73_10490	COG4656	Part of a membrane complex involved in electron transport
E4N73_10495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N73_10510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N73_10515	COG0825	malonyl-CoA metabolic process
E4N73_10525	COG0395	ABC-type sugar transport system, permease component
E4N73_10530	COG1175	transmembrane transport
E4N73_10555	COG0402	S-adenosylhomocysteine deaminase activity
E4N73_10560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4N73_10565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N73_10570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N73_10580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N73_10595	COG0039	L-malate dehydrogenase activity
E4N73_10600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N73_10630	COG2910	NAD(P)H-binding
E4N73_10635	COG1733	regulation of RNA biosynthetic process
E4N73_10650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N73_10660	COG1401	restriction endodeoxyribonuclease activity
E4N73_10675	COG2375	cellular response to nickel ion
E4N73_10675	COG1132	(ABC) transporter
E4N73_10680	COG1132	(ABC) transporter
E4N73_10710	COG1129	ABC transporter
E4N73_10715	COG2801	Transposase and inactivated derivatives
E4N73_10725	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N73_10755	COG1129	ABC transporter
E4N73_10820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N73_10825	COG1120	ATPase activity
E4N73_10850	COG1129	ABC transporter
E4N73_10860	COG1132	(ABC) transporter
E4N73_10860	COG2375	cellular response to nickel ion
E4N73_10910	COG2801	Transposase and inactivated derivatives
E4N73_10985	COG2314	TM2 domain
E4N73_11065	COG1132	(ABC) transporter
E4N73_11080	COG1129	ABC transporter
E4N73_11085	COG1132	(ABC) transporter
E4N73_11095	COG1309	transcriptional regulator
E4N73_11110	COG0346	lactoylglutathione lyase activity
E4N73_11130	COG0783	Belongs to the Dps family
E4N73_11135	COG1881	PFAM PEBP family protein
E4N73_11160	COG1222	aaa ATPase
E4N73_11185	COG1393	Belongs to the ArsC family
E4N73_11210	COG1122	ATPase activity
E4N73_11225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N73_11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N73_11235	COG0840	transmembrane signaling receptor activity
E4N73_11250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N73_11260	COG0840	transmembrane signaling receptor activity
E4N73_11280	COG0457	Tetratricopeptide repeat
E4N73_11285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N73_11310	COG0494	nUDIX hydrolase
E4N73_11330	COG0768	penicillin binding
E4N73_11335	COG2604	Protein of unknown function DUF115
E4N73_11350	COG1193	negative regulation of DNA recombination
E4N73_11355	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N73_11360	COG0492	ferredoxin-NADP+ reductase activity
E4N73_11375	COG0714	Associated with various cellular activities
E4N73_11410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N73_11490	COG0629	single-stranded DNA binding
E4N73_11495	COG0281	malic enzyme
E4N73_11535	COG0741	lytic transglycosylase activity
E4N73_11540	COG1968	undecaprenyl-diphosphatase activity
E4N73_11545	COG1674	ftsk spoiiie
E4N73_11550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4N73_11570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N73_11575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N73_11580	COG0084	hydrolase, TatD family'
E4N73_11590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N73_11610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N73_11645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N73_11655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N73_11660	COG0740	serine-type endopeptidase activity
E4N73_11665	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N73_11695	COG2203	Gaf domain
E4N73_11695	COG2199	diguanylate cyclase activity
E4N73_11700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N73_11715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N73_11715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N73_11720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N73_11725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N73_11750	COG0280	phosphate acetyltransferase
E4N73_11755	COG0653	protein targeting
E4N73_11770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N73_11775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N73_11775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N73_11785	COG1132	(ABC) transporter
E4N73_11790	COG1132	(ABC) transporter
E4N73_11800	COG1162	GTPase activity
E4N73_11815	COG3328	transposase activity
E4N73_11830	COG1002	Type II restriction enzyme, methylase subunits
E4N73_11875	COG0840	transmembrane signaling receptor activity
E4N73_11885	COG0840	transmembrane signaling receptor activity
E4N73_11890	COG2211	Major facilitator Superfamily
E4N73_11910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N73_11915	COG1120	ATPase activity
E4N73_11930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N73_11935	COG4452	Inner membrane protein CreD
E4N73_11950	COG0488	(ABC) transporter
E4N73_11980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N73_11985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N73_12035	COG1111	helicase
E4N73_12035	COG1205	dead DEAH box helicase
E4N73_12040	COG2183	response to ionizing radiation
E4N73_12050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N73_12055	COG0423	glycine-tRNA ligase activity
E4N73_12065	COG0584	glycerophosphoryl diester phosphodiesterase
E4N73_12105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N73_12135	COG0640	Transcriptional regulator
E4N73_12140	COG2217	Heavy metal translocating P-type atpase
E4N73_12145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N73_12180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N73_12200	COG0156	8-amino-7-oxononanoate synthase activity
E4N73_12205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N73_12245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N73_12250	COG0024	Methionine aminopeptidase
E4N73_12255	COG0484	heat shock protein binding
E4N73_12290	COG0425	Belongs to the sulfur carrier protein TusA family
E4N73_12305	COG3842	ATPase activity
E4N73_12310	COG1175	transmembrane transport
E4N73_12315	COG0395	ABC-type sugar transport system, permease component
E4N73_12320	COG1653	transport
E4N73_12340	COG0438	transferase activity, transferring glycosyl groups
E4N73_12340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N73_12345	COG0739	heme binding
E4N73_12350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N73_12365	COG0701	Predicted permease
E4N73_12370	COG0116	Belongs to the methyltransferase superfamily
E4N73_12400	COG5001	Diguanylate cyclase
E4N73_12405	COG0012	GTP binding
E4N73_12420	COG1132	(ABC) transporter
E4N73_12425	COG0326	Molecular chaperone. Has ATPase activity
E4N73_12430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N73_12440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N73_12470	COG4115	mRNA cleavage
E4N73_12475	COG1074	ATP-dependent DNA helicase activity
E4N73_12480	COG1132	(ABC) transporter
E4N73_12490	COG0237	dephospho-CoA kinase activity
E4N73_12500	COG0739	heme binding
E4N73_12505	COG0840	transmembrane signaling receptor activity
E4N73_12510	COG1114	Component of the transport system for branched-chain amino acids
E4N73_12515	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N73_12520	COG4750	Nucleotidyl transferase
E4N73_12530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities