locus-tag class description Ava_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Ava_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Ava_0003 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ava_0005 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Ava_0017 ENOG4105CHM Aminotransferase Ava_0018 ENOG4107YCR Transcriptional regulator, ARSR family Ava_0021 ENOG4105DWF phosphomethylpyrimidine kinase Ava_0022 ENOG4105CKK Glycosyl transferase, family 2 Ava_0023 ENOG4105C01 Dihydroxy-acid dehydratase Ava_0026 ENOG41080HI glycine oxidase Ava_0027 ENOG4105VFU Rna-binding protein Ava_0032 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Ava_0036 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Ava_0039 ENOG4108HMN Caspase domain Ava_0044 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Ava_0045 ENOG4105PWN phosphate abc transporter Ava_0046 ENOG4105C8U phosphate abc transporter Ava_0047 ENOG4105E2Z phosphate ABC transporter (Permease Ava_0048 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ava_0055 ENOG4105BZU Histidine kinase Ava_0056 ENOG4108E1C hydrolase Ava_0057 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Ava_0059 ENOG4105M3Z response regulator Ava_0061 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ava_0062 ENOG4105CBS Chea signal transduction histidine kinase Ava_0065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_0066 ENOG4105BZU Histidine kinase Ava_0068 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ava_0074 ENOG4108XNA Gas vesicle Ava_0075 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) Ava_0078 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth Ava_0079 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth Ava_0083 ENOG4105BZU Histidine kinase Ava_0088 ENOG4105D0M Protease HtpX homolog Ava_0090 ENOG4105BZF Glycosyl transferase (Group 1 Ava_0091 ENOG4105F8J Adenylate Guanylate cyclase Ava_0093 ENOG4107QPR SAICAR synthetase Ava_0094 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Ava_0095 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Ava_0096 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Ava_0097 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Ava_0098 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Ava_0103 ENOG4105E1J oxidoreductase Ava_0104 ENOG4107T8P acyl-Coa dehydrogenase Ava_0108 ENOG4105CPC Aldo Keto reductase Ava_0109 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Ava_0111 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Ava_0112 ENOG4105E6M Sulphatase-modifying factor protein Ava_0113 ENOG4107XGZ Hydrolase Ava_0115 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Ava_0116 ENOG4105CHW UPF0052 protein Ava_0118 ENOG4105K8N protein family UPF0079, ATPase Ava_0120 ENOG4105CD3 dihydroorotase Ava_0123 ENOG4105BZU Histidine kinase Ava_0124 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_0126 ENOG4105CD2 stage iii sporulation protein aa Ava_0128 ENOG4105VFU Rna-binding protein Ava_0130 ENOG4105ERG peptidase m48, ste24p Ava_0133 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Ava_0134 ENOG4108FN7 Aldo keto reductase Ava_0140 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Ava_0142 ENOG41083EU 50s ribosomal protein l28 Ava_0144 ENOG4105IJJ transcriptional regulator, crp fnr family Ava_0145 ENOG4105CN1 protease Ava_0146 ENOG4108TCG allophycocyanin beta subunit Ava_0147 ENOG4105C5F glutamine synthetase Ava_0149 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ava_0154 ENOG4105CPQ Dehydrogenase Ava_0155 ENOG4105CJ3 phosphate transporter Ava_0158 ENOG4108K9Q Controls heterocyst differentiation. Has both a protease and a DNA-binding activity (By similarity) Ava_0159 ENOG4105CHM Aminotransferase Ava_0160 ENOG4105N6Y Thioredoxin Ava_0166 ENOG4108IPT Naphthoate synthase Ava_0169 ENOG4105DBI uridine monophosphokinase Ava_0172 ENOG4105W5Q DNA repair protein (RadC Ava_0176 ENOG4105DCF alanine dehydrogenase Ava_0183 ENOG4105DR5 peptidase Ava_0185 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Ava_0187 ENOG4105K63 Thioredoxin Ava_0188 ENOG4105NAN IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Ava_0191 ENOG4105CJ1 ABC, transporter Ava_0194 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Ava_0196 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Ava_0200 ENOG4105CVN desaturase Ava_0207 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP Ava_0208 ENOG410715G filament integrity protein Ava_0209 ENOG4105RRH Ava_0214 ENOG4108JPW Aminotransferase Ava_0219 ENOG4107WDG serine threonine protein kinase Ava_0224 ENOG4105BZU Histidine kinase Ava_0226 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Ava_0239 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_0242 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Ava_0243 ENOG4108IJ6 ABC transporter Ava_0247 ENOG4105C9M aspartyl-trna synthetase Ava_0252 ENOG4108RVA ribokinase Ava_0257 ENOG4108DIG cyanophycin synthetase Ava_0259 ENOG4105F32 YngK protein Ava_0262 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Ava_0263 ENOG41060D5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Ava_0267 ENOG4105X0D Fimbrial protein Ava_0274 ENOG4106WTF Glycosyl transferase, family 2 Ava_0276 ENOG4107Y1F Involved in the transcription termination process (By similarity) Ava_0278 ENOG4107SGM protein serine threonine phosphatase Ava_0282 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Ava_0285 ENOG4105CKI cobalamin synthesis protein Ava_0288 ENOG4105DSE periplasmic solute binding protein Ava_0291 ENOG4108RXX maleylacetoacetate isomerase Ava_0295 ENOG4105CFG Acts as a chaperone (By similarity) Ava_0296 ENOG4105CFP Peptidase U32 Ava_0299 ENOG4105CN1 protease Ava_0300 ENOG4107R8N Glycosyl transferase, family 2 Ava_0303 ENOG4105GHY electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) Ava_0313 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Ava_0314 ENOG4105BZU Histidine kinase Ava_0315 ENOG410841Q phosphoesterase PA-phosphatase related protein Ava_0316 ENOG4105CD8 aminopeptidase N Ava_0324 ENOG4107EF8 Glycosyl transferase (Group 1 Ava_0325 ENOG4105BZ1 (ABC) transporter Ava_0328 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Ava_0329 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Ava_0330 ENOG4105CDU Replicative dna helicase Ava_0330 ENOG4105CDU Replicative dna helicase Ava_0334 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Ava_0337 ENOG4105DDG Cyanophycinase Ava_0344 ENOG4105CA3 membrane-bound lytic murein transglycosylase Ava_0347 ENOG4108UK5 Transposase Ava_0355 ENOG4105BZU Histidine kinase Ava_0356 ENOG4108R99 pseudouridine synthase Ava_0357 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Ava_0360 ENOG4105CPF Cell wall formation (By similarity) Ava_0362 ENOG4105BZU Histidine kinase Ava_0367 ENOG4105WEF catalase Ava_0375 ENOG4105CZX twitching motility protein Ava_0376 ENOG4107QHF type ii secretion system protein e Ava_0377 ENOG4107Z9D Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Ava_0378 ENOG4105CFG Acts as a chaperone (By similarity) Ava_0379 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ava_0381 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Ava_0382 ENOG4107RFW hydrolase family 57 Ava_0384 ENOG4105D1D Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Ava_0385 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Ava_0390 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Ava_0397 ENOG4105WGP Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity) Ava_0407 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Ava_0411 ENOG4108KGH TRANSCRIPTIONal Ava_0413 ENOG4105BZU Histidine kinase Ava_0418 ENOG4105CJ1 ABC, transporter Ava_0420 ENOG41080XM UPF0145 protein Ava_0429 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Ava_0430 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Ava_0433 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Ava_0434 ENOG4105D9P serine threonine protein kinase Ava_0435 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Ava_0437 ENOG4105C3J Cysteine desulfurase Ava_0440 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Ava_0441 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ava_0445 ENOG4105WCA Ferredoxin Ava_0451 ENOG4105ND9 Nitrogenase-associated protein Ava_0460 ENOG4108UR2 Nitrogen fixation protein NifX Ava_0463 ENOG4108W3Y Transcriptional regulator, Crp Fnr family Ava_0466 ENOG4105C32 Amino acid ABC transporter (Permease) Ava_0470 ENOG4105C0Z ABC transporter Ava_0473 ENOG4108IV0 ABC, transporter Ava_0474 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Ava_0482 ENOG4108TNP Ava_0485 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Ava_0490 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Ava_0493 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Ava_0495 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Ava_0496 ENOG4107QRI Phosphoketolase Ava_0497 ENOG4108N5B 2-phosphosulfolactate phosphatase Ava_0499 ENOG4105D0M Protease HtpX homolog Ava_0501 ENOG4108JA5 May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs (By similarity) Ava_0505 ENOG4105CBS Chea signal transduction histidine kinase Ava_0505 ENOG4105CBS Chea signal transduction histidine kinase Ava_0506 ENOG4105C8Q Methyl-accepting chemotaxis Ava_0511 ENOG4107UAN Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Ava_0513 ENOG4105CRE cytochrome C Ava_0516 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Ava_0518 ENOG4106AG1 Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity) Ava_0523 ENOG4105E33 succinate dehydrogenase Ava_0526 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Ava_0540 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Ava_0545 ENOG4105C7Z Conserved Protein Ava_0547 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ava_0553 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Ava_0554 ENOG4105CAS nag kinase Ava_0557 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Ava_0564 ENOG4108V3E phosphoribosylglycinamide formyltransferase Ava_0572 ENOG4105CFG Acts as a chaperone (By similarity) Ava_0573 ENOG4105E5J UV damage endonuclease Ava_0578 ENOG4105J0U photosystem II Ava_0586 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Ava_0587 ENOG4105W3H MtN3 and saliva related transmembrane protein Ava_0589 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Ava_0592 ENOG4105EPU Molybdenum cofactor synthesis domain protein Ava_0593 ENOG4105MSA Photosystem II reaction center W protein Ava_0597 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Ava_0599 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ava_0602 ENOG4108IND Tetr family transcriptional regulator Ava_0607 ENOG4105ZDA Ava_0612 ENOG4105BZU Histidine kinase Ava_0613 ENOG4105BZU Histidine kinase Ava_0615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_0628 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Ava_0629 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Ava_0631 ENOG4105CI2 imidazolone-5-propionate hydrolase Ava_0633 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Ava_0635 ENOG41060KK Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity) Ava_0636 ENOG4108IYU L-aspartate oxidase Ava_0638 ENOG4105BZU Histidine kinase Ava_0639 ENOG4105CVB Vitamin K epoxide reductase Ava_0641 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Ava_0647 ENOG4105BZU Histidine kinase Ava_0648 ENOG4105BZU Histidine kinase Ava_0649 ENOG4105BZU Histidine kinase Ava_0659 ENOG4105CAK Cell division ATP-binding protein ftsE Ava_0661 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_0662 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Ava_0668 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Ava_0671 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Ava_0673 ENOG4106F1P AAA ATPase, central domain protein Ava_0676 ENOG4105C7B Threonine dehydratase Ava_0679 ENOG4105BZU Histidine kinase Ava_0681 ENOG4105CPC Aldo Keto reductase Ava_0682 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Ava_0684 ENOG4107NA1 Endonuclease Exonuclease phosphatase Ava_0685 ENOG4105D74 hydrolase Ava_0690 ENOG4108USA electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) Ava_0691 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Ava_0692 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Ava_0693 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Ava_0694 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Ava_0695 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Ava_0696 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Ava_0697 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Ava_0698 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Ava_0699 ENOG410848H 50s ribosomal protein l29 Ava_0700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Ava_0701 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Ava_0702 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Ava_0703 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Ava_0704 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Ava_0705 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Ava_0706 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Ava_0707 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Ava_0708 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Ava_0709 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Ava_0710 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Ava_0712 ENOG41067V7 50S ribosomal protein L36 Ava_0713 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Ava_0714 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Ava_0715 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Ava_0716 ENOG4108ZT0 50S ribosomal protein l17 Ava_0717 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Ava_0718 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Ava_0719 ENOG4108UJD 30S ribosomal protein S9 Ava_0720 ENOG41082HT Binds the 23S rRNA (By similarity) Ava_0721 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Ava_0722 ENOG4105C5H ABC transporter Ava_0723 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Ava_0727 ENOG4108KMV Glycosyl transferase (Group 1 Ava_0729 ENOG4107XHR Involved in DNA repair and RecF pathway recombination (By similarity) Ava_0730 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Ava_0736 ENOG4106CD9 glycosyl transferase group 1 Ava_0737 ENOG4105CDA abc transporter atp-binding protein Ava_0738 ENOG4105DRP amino acid AbC transporter Ava_0739 ENOG4105EZ7 amino acid ABC transporter Ava_0740 ENOG4107QXX ABC transporter Ava_0743 ENOG4107WPW Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Ava_0744 ENOG4105D3Q Sugar transferase Ava_0748 ENOG4105C8S subunit m Ava_0749 ENOG4105D65 subunit l Ava_0750 ENOG4107XWB Zinc finger, swim domain protein Ava_0751 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) Ava_0755 ENOG4105D9R oxidoreductase Ava_0756 ENOG410811Q Ferredoxin Ava_0757 ENOG4105JFG SpoIID LytB domain protein Ava_0772 ENOG4105BZA Phosphoglycerate kinase Ava_0775 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Ava_0780 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Ava_0782 ENOG4107SC0 ferredoxin--NADP reductase Ava_0784 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Ava_0791 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_0792 ENOG4105BZU Histidine kinase Ava_0793 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Ava_0794 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Ava_0795 ENOG4105D7N magnesium and cobalt transport protein CorA Ava_0797 ENOG4107Z8V Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Ava_0798 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Ava_0799 ENOG4105BZU Histidine kinase Ava_0805 ENOG4105FIK Inherit from COG: dihydropteroate synthase Ava_0807 ENOG41080UQ Transcriptional regulator Ava_0814 ENOG4105C0H protease Ava_0816 ENOG4105C0P Mg chelatase subunit ChlI Ava_0817 ENOG4107YU2 histidine triad (hIT) protein Ava_0819 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) Ava_0823 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Ava_0824 ENOG4107RSM transcriptional regulator Ava_0825 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Ava_0826 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Ava_0830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Ava_0836 ENOG4108Z03 MAF-like protein Ava_0837 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Ava_0839 ENOG4105PSV Polysaccharide Biosynthesis Protein Ava_0840 ENOG4108SHN Glycosyl transferase, family 2 Ava_0841 ENOG4108SHN Glycosyl transferase, family 2 Ava_0842 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_0845 ENOG4108ZPC Polysaccharide pyruvyl transferase Ava_0846 ENOG4105PSV Polysaccharide Biosynthesis Protein Ava_0847 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_0849 ENOG4105K64 Glycosyl transferase, family 2 Ava_0852 ENOG4105D75 Capsular exopolysaccharide family Ava_0853 ENOG4105CG5 Glycosyl transferase (Group 1 Ava_0854 ENOG4108KMV Glycosyl transferase (Group 1 Ava_0855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Ava_0856 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Ava_0861 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Ava_0867 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase Ava_0868 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_0869 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_0873 ENOG4105BZU Histidine kinase Ava_0876 ENOG4105D7T ABC transporter Ava_0881 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Ava_0883 ENOG4105CH5 extracellular solute-binding protein, family 7 Ava_0884 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Ava_0890 ENOG4105D64 Mechanosensitive ion channel Ava_0893 ENOG4108UN4 phage SPO1 DNA polymerase-related protein Ava_0895 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Ava_0911 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Ava_0913 ENOG4105C8B TIGR00159 family Ava_0914 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Ava_0919 ENOG4108KBA Acts as a chaperone (By similarity) Ava_0920 ENOG4107VAM peptidase, m28 Ava_0922 ENOG4105FFC UPF0187 protein Ava_0924 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Ava_0925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Ava_0926 ENOG4108JQC penicillin-binding protein 1A Ava_0933 ENOG4105CHC glucokinase (EC 2.7.1.2) Ava_0938 ENOG4107S73 homocitrate synthase Ava_0940 ENOG4105CVP deoxyribo-dipyrimidine photolyase Ava_0942 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Ava_0950 ENOG4108JQC penicillin-binding protein 1A Ava_0951 ENOG4105CB5 ATP-dependent DNA helicase recG Ava_0957 ENOG4108DJF Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Ava_0958 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Ava_0961 ENOG4105DB7 PHP domain protein Ava_0963 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Ava_0964 ENOG4105CAT Cytidine monophosphate kinase Ava_0965 ENOG4105K6T rare lipoprotein A Ava_0966 ENOG4105CSV Glutaminase Ava_0967 ENOG4105CA3 membrane-bound lytic murein transglycosylase Ava_0973 ENOG4108UHE carbonic anhydrase Ava_0974 ENOG4105VFU Rna-binding protein Ava_0976 ENOG41081UC Inherit from COG: Competence protein Ava_0980 ENOG4105DTD Dehydrogenase Ava_0984 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ava_0985 ENOG410811H Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Ava_0986 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_0988 ENOG4108IV0 ABC, transporter Ava_0989 ENOG4107R0W ABC transporter Ava_0990 ENOG4108V9Q carbonic anhydrase Ava_0992 ENOG4105C59 p-type ATPase Ava_1002 ENOG4105PGM cation diffusion facilitator family transporter Ava_1003 ENOG4105BZU Histidine kinase Ava_1005 ENOG4105BZU Histidine kinase Ava_1007 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Ava_1008 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Ava_1011 ENOG4108W6C Dehydrogenase Ava_1016 ENOG4105EHU Circadian clock protein KaiC Ava_1017 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) Ava_1020 ENOG4108WXF Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation Ava_1021 ENOG4105BZU Histidine kinase Ava_1028 ENOG4105CNG UPF0061 protein Ava_1029 ENOG4105BZU Histidine kinase Ava_1034 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Ava_1041 ENOG4105CPK Glycosyl transferase (Group 1 Ava_1045 ENOG4107YJ4 chain length determinant protein Ava_1048 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Ava_1053 ENOG4107VQD May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Ava_1054 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Ava_1062 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Ava_1063 ENOG4105KVH Transcriptional regulator Ava_1067 ENOG4107VEG TrkA-N domain protein Ava_1075 ENOG4105CE1 Ferrous iron transport protein b Ava_1080 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Ava_1087 ENOG4105C4W S-formylglutathione hydrolase Ava_1089 ENOG4107QPD alcohol dehydrogenase Ava_1090 ENOG4105JKW Valine--pyruvate aminotransferase Ava_1091 ENOG41080P6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Ava_1102 ENOG4108UNF response regulator Ava_1103 ENOG4108M24 von Willebrand factor, type A Ava_1106 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Ava_1107 ENOG4105D5U fad dependent oxidoreductase Ava_1108 ENOG4105CMR udp-glucose 4-epimerase Ava_1113 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Ava_1115 ENOG4108TJN glycosyl transferase group 1 Ava_1116 ENOG4107YJ4 chain length determinant protein Ava_1117 ENOG4105D3Q Sugar transferase Ava_1118 ENOG4105BZ1 (ABC) transporter Ava_1119 ENOG4108SHN Glycosyl transferase, family 2 Ava_1122 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_1138 ENOG4105FTV AraC Family Transcriptional Regulator Ava_1139 ENOG4107T8Q Glycosyl transferase (Group 1 Ava_1143 ENOG4105D5K Hemolysin activator protein Ava_1147 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Ava_1149 ENOG4105BZU Histidine kinase Ava_1153 ENOG4105D9P serine threonine protein kinase Ava_1156 ENOG4105DZR Type I site-specific deoxyribonuclease Ava_1157 ENOG4105CB5 ATP-dependent DNA helicase recG Ava_1158 ENOG4107XZC Restriction modification system DNA (Specificity Ava_1162 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Ava_1163 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Ava_1164 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_1165 ENOG4107XWZ ferric uptake regulator Ava_1167 ENOG4105CTK cobaltochelatase, cobn subunit Ava_1168 ENOG4105BZU Histidine kinase Ava_1172 ENOG4105CJW magnesium transporter Ava_1174 ENOG4105CXT aspartate transcarbamylase Ava_1175 ENOG4105C08 Histidine kinase Ava_1177 ENOG4107QN1 sodium solute Ava_1180 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Ava_1182 ENOG4108MV2 Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity) Ava_1186 ENOG4106CD9 glycosyl transferase group 1 Ava_1188 ENOG4108JJA ABC, transporter Ava_1189 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Ava_1192 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Ava_1194 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_1195 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_1196 ENOG4105QPS Monooxygenase Ava_1198 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_1200 ENOG4105NP4 Functions as an electron carrier between membrane-bound cytochrome b6-f and photosystem I in oxygenic photosynthesis (By similarity) Ava_1204 ENOG4105D82 Glutamate dehydrogenase Ava_1206 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Ava_1213 ENOG4108302 MgtC SapB transporter Ava_1222 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Ava_1225 ENOG4105VUN Transcriptional regulator Ava_1228 ENOG4105CDY transcriptional regulatory protein Ava_1238 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Ava_1239 ENOG41068WN Ava_1241 ENOG4108S5W Seems to be required for the assembly of the photosystem I complex (By similarity) Ava_1242 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) Ava_1246 ENOG4108E1C hydrolase Ava_1248 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ava_1255 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_1262 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Ava_1263 ENOG4105EEX Two component transcriptional regulator (Winged helix family Ava_1266 ENOG4105CPU Monooxygenase Ava_1267 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Ava_1270 ENOG4105WN2 Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase (By similarity) Ava_1271 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Ava_1272 ENOG4105X1F electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity) Ava_1273 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Ava_1275 ENOG4105J3Z Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Ava_1277 ENOG4105CHM Aminotransferase Ava_1280 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Ava_1282 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Ava_1283 ENOG4108XAD Protein of unknown function (DUF1997) Ava_1285 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Ava_1286 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Ava_1287 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Ava_1288 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Ava_1289 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Ava_1290 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Ava_1292 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Ava_1295 ENOG4108ZJ4 polysaccharide deacetylase Ava_1297 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Ava_1300 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Ava_1305 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ava_1306 ENOG41084IE Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ava_1309 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase Ava_1312 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Ava_1316 ENOG4105CFG Acts as a chaperone (By similarity) Ava_1320 ENOG41084GG 50S ribosomal protein L33 Ava_1321 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Ava_1325 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Ava_1336 ENOG4105VMP Transcriptional regulator Ava_1350 ENOG410890F Dynamin family Ava_1351 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ava_1356 ENOG4105CNF WD-40 repeat protein Ava_1358 ENOG4105D3R alkyl hydroperoxide reductase Ava_1362 ENOG4107STW synthase Ava_1365 ENOG4105CPK Glycosyl transferase (Group 1 Ava_1366 ENOG4107RGC Glycosyl transferase, family 2 Ava_1369 ENOG4105CNW domain protein Ava_1371 ENOG4105CNW domain protein Ava_1374 ENOG4105D3Q Sugar transferase Ava_1375 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family Ava_1379 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_1385 ENOG4105K64 Glycosyl transferase, family 2 Ava_1397 ENOG4107S78 Band 7 protein Ava_1400 ENOG4105EYM Major Facilitator superfamily Ava_1405 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Ava_1410 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_1411 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_1416 ENOG4108R6K riboflavin synthase, subunit alpha Ava_1417 ENOG41063SB peptidase Ava_1418 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Ava_1420 ENOG4105C09 Bile acid Ava_1421 ENOG4106MP8 UPF0754 membrane protein Ava_1422 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) Ava_1423 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Ava_1425 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Ava_1433 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Ava_1434 ENOG4105D0M Protease HtpX homolog Ava_1435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Ava_1438 ENOG4105CNW domain protein Ava_1439 ENOG4105CNW domain protein Ava_1447 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_1452 ENOG4105CJ1 ABC, transporter Ava_1461 ENOG4105DFF Rod shape-determining protein mreb Ava_1462 ENOG41080E3 single-stranded DNA-binding protein Ava_1465 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ava_1466 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase Ava_1467 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Ava_1474 ENOG4105KC4 UPF0296 protein Ava_1475 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Ava_1476 ENOG4108W6I photosystem I reaction center protein subunit XI Ava_1477 ENOG4106AST May help in the organization of the PsaE and PsaF subunits (By similarity) Ava_1478 ENOG4108VV8 photosystem i Ava_1479 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Ava_1485 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Ava_1486 ENOG4105BZU Histidine kinase Ava_1489 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Ava_1495 ENOG4108IJ6 ABC transporter Ava_1498 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_1505 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Ava_1507 ENOG4105YVZ photosystem II Ava_1509 ENOG4105DEF Extracellular solute-binding protein, family 5 Ava_1510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ava_1511 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Ava_1515 ENOG4105K46 50S ribosomal protein l27 Ava_1516 ENOG41082FX This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Ava_1519 ENOG4105EET magnesium chelatase Ava_1520 ENOG4105FQP Beta-lactamase Ava_1526 ENOG4107T8Q Glycosyl transferase (Group 1 Ava_1527 ENOG4105CPK Glycosyl transferase (Group 1 Ava_1529 ENOG4105TQG cytochrome C, class I Ava_1532 ENOG41086DT Membrane protein of unknown function Ava_1534 ENOG4105BZM domain protein Ava_1536 ENOG4107SKI cobyrinic Acid a,c-diamide synthase Ava_1544 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Ava_1548 ENOG4105C59 p-type ATPase Ava_1556 ENOG4108HMN Caspase domain Ava_1558 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_1560 ENOG4105BZU Histidine kinase Ava_1561 ENOG4105BZU Histidine kinase Ava_1562 ENOG4105BZU Histidine kinase Ava_1564 ENOG4105BZU Histidine kinase Ava_1566 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_1567 ENOG41082AN stage II sporulation protein Ava_1568 ENOG4107QJZ Glycosyl transferase, family 2 Ava_1572 ENOG4108W6C Dehydrogenase Ava_1574 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_1577 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Ava_1581 ENOG4105EWK phytoene Ava_1583 ENOG41088WE This is one of the two reaction center proteins of photosystem II Ava_1584 ENOG4105EA8 2-Nitropropane dioxygenase Ava_1586 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Ava_1590 ENOG4105EIE fructose-bisphosphate aldolase Ava_1592 ENOG4107WDG serine threonine protein kinase Ava_1593 ENOG4107S1Q Phosphatase Ava_1594 ENOG4105DXX methyltransferase Ava_1596 ENOG4108IG5 Transcriptional regulator Ava_1597 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II Ava_1598 ENOG4105DF7 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Ava_1599 ENOG4105CC5 ABC transporter Ava_1600 ENOG4105DIK (ABC) transporter Ava_1601 ENOG4105DSE periplasmic solute binding protein Ava_1609 ENOG4105C0W non-ribosomal peptide synthetase Ava_1626 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_1627 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_1628 ENOG4105BZU Histidine kinase Ava_1631 ENOG4105D8X mechanosensitive ion channel Ava_1638 ENOG4108IUZ ABC transporter Ava_1643 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Ava_1646 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Ava_1647 ENOG4107SQU synthase Ava_1649 ENOG4107RCI amp-dependent synthetase and ligase Ava_1651 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Ava_1653 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Ava_1655 ENOG4108HHA Transketolase Ava_1659 ENOG4105CHF Glutathione S-transferase Ava_1661 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Ava_1668 ENOG4105D7W serine acetyltransferase Ava_1669 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Ava_1671 ENOG4105X25 Ava_1672 ENOG4107ZSV Receptor Ava_1674 ENOG4105C4M (Ubiquinol oxidase) subunit I Ava_1679 ENOG4105VFU Rna-binding protein Ava_1680 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Ava_1681 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Ava_1682 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Ava_1683 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA Ava_1691 ENOG4108VHC Short-chain dehydrogenase reductase Sdr Ava_1700 ENOG4107WDG serine threonine protein kinase Ava_1704 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Ava_1709 ENOG4105EYH Exonuclease Ava_1716 ENOG4105BZU Histidine kinase Ava_1718 ENOG4108SHJ s-layer protein Ava_1719 ENOG4105BZU Histidine kinase Ava_1724 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Ava_1730 ENOG4105DZP Membrane-associated zinc metalloprotease Ava_1732 ENOG41082AF Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Ava_1734 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Ava_1737 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Ava_1745 ENOG4105C8S subunit m Ava_1747 ENOG4105K63 Thioredoxin Ava_1749 ENOG4105DUM transcriptional regulator, lysR family Ava_1751 ENOG4105C75 arginyL-tRNA synthetase Ava_1752 ENOG410667J hydrolase Ava_1753 ENOG4108JJB ABC transporter Ava_1755 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein Ava_1756 ENOG4108JJB ABC transporter Ava_1757 ENOG4108V4M Cobalt abc transporter Ava_1758 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Ava_1759 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Ava_1760 ENOG4105E3B Multicopper oxidase Ava_1764 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Ava_1766 ENOG4107QZB decarboxylase Ava_1767 ENOG4105K70 DNA-binding protein Ava_1768 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Ava_1769 ENOG4105F32 YngK protein Ava_1775 ENOG4105D44 asparaginase Ava_1776 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Ava_1777 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_1778 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Ava_1779 ENOG4105KHC sulfurtransferase Ava_1783 ENOG4105CMV Succinyl-CoA synthetase subunit beta Ava_1784 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Ava_1785 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) Ava_1786 ENOG4105CUG Oligopeptidase b Ava_1788 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Ava_1789 ENOG4107P5I polyketide synthase Ava_1793 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Ava_1796 ENOG4105E0X reductase Ava_1800 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Ava_1801 ENOG4107ZH9 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Ava_1802 ENOG4105CNW domain protein Ava_1803 ENOG4105CNW domain protein Ava_1807 ENOG4105CH7 arginosuccinase Ava_1809 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Ava_1810 ENOG4107QRA Extracellular solute-binding protein, family 5 Ava_1811 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Ava_1812 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Ava_1813 ENOG4105DDG Cyanophycinase Ava_1814 ENOG4107RRY Cyanophycin synthetase Ava_1815 ENOG41063NY Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Ava_1816 ENOG4107WDG serine threonine protein kinase Ava_1817 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Ava_1826 ENOG4105C9B Cysteine desulfurase Ava_1829 ENOG4105D7V transposase Ava_1830 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Ava_1834 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Ava_1836 ENOG4105D7Z glutathione synthase Ava_1837 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Ava_1841 ENOG4108HMN Caspase domain Ava_1843 ENOG4105CPJ photosystem II manganese-stabilizing Ava_1852 ENOG4106DN3 This protein is a component of the reaction center of photosystem II (By similarity) Ava_1854 ENOG410689D This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) Ava_1855 ENOG4105NT3 This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity) Ava_1856 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity Ava_1857 ENOG410828V rubredoxin Ava_1858 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Ava_1859 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_1860 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Ava_1863 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Ava_1867 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Ava_1870 ENOG4105CHV Transcription elongation factor NusA Ava_1871 ENOG4107ZR3 Required for maturation of 30S ribosomal subunits (By similarity) Ava_1889 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Ava_1890 ENOG4105M6F mutator MutT protein Ava_1892 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_1893 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Ava_1894 ENOG4108NWW ferritin dps family protein Ava_1896 ENOG4105E0R Deoxyhypusine synthase Ava_1898 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Ava_1901 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Ava_1902 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ava_1904 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Ava_1905 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_1911 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Ava_1914 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Ava_1917 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_1918 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Ava_1921 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Ava_1922 ENOG4105ETX regulatoR Ava_1926 ENOG4105DK0 Indole-3-glycerol phosphate synthase Ava_1931 ENOG4108PWY Carbohydrate-selective porin OprB Ava_1940 ENOG4105CTK cobaltochelatase, cobn subunit Ava_1941 ENOG4105BZ1 (ABC) transporter Ava_1942 ENOG4105BZ1 (ABC) transporter Ava_1944 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_1945 ENOG4105BZU Histidine kinase Ava_1946 ENOG4105D52 delta-aminolevulinic acid dehydratase Ava_1947 ENOG4105C22 threonyL-tRNA synthetase Ava_1948 ENOG4105CKI cobalamin synthesis protein Ava_1949 ENOG4105EUJ GTP cyclohydrolase i Ava_1951 ENOG4105D3Q Sugar transferase Ava_1952 ENOG4105C1J atp-dependent rna helicase Ava_1955 ENOG4105BZ1 (ABC) transporter Ava_1957 ENOG4105CMR udp-glucose 4-epimerase Ava_1959 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Ava_1960 ENOG4107VAM peptidase, m28 Ava_1962 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Ava_1963 ENOG4107QRG dna polymerase iii Ava_1966 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Ava_1967 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Ava_1968 ENOG4105CIA precorrin-4 C(11)-methyltransferase Ava_1970 ENOG4108YZN class I peptide chain release factor Ava_1972 ENOG41080ZE Adenylate cyclase Ava_1975 ENOG4105K56 Transcriptional regulator Ava_1977 ENOG4108KQJ Type 11 methyltransferase Ava_1981 ENOG4105JZI cytochrome P450 Ava_1982 ENOG4108X7A Terpene synthase metal-binding domain-containing protein Ava_1985 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Ava_1989 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Ava_1991 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Ava_1994 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Ava_1995 ENOG4107WDG serine threonine protein kinase Ava_1996 ENOG4107Y82 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Ava_2001 ENOG4108VPT UPF0234 protein Ava_2002 ENOG4105CYM Glutathione S-transferase Ava_2006 ENOG4107S5T Carbohydrate kinase Ava_2007 ENOG4105RD7 BadF BadG BcrA BcrD Ava_2010 ENOG41063FQ CsbD-like protein Ava_2015 ENOG4105WXN Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Ava_2018 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ava_2020 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Ava_2027 ENOG4105BZU Histidine kinase Ava_2028 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_2029 ENOG4108Z6B deaminase Ava_2030 ENOG4105EYW Ion transport protein Ava_2032 ENOG4105EWK phytoene Ava_2038 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Ava_2045 ENOG4108JQ6 ABC transporter Ava_2050 ENOG4108IJ9 (ABC) transporter Ava_2053 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Ava_2054 ENOG41085RW This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Ava_2055 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Ava_2060 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Ava_2061 ENOG4105CE9 30S ribosomal protein S2 Ava_2064 ENOG4107R51 Glycosyl transferase, family 2 Ava_2068 ENOG4105CDH Citrulline--aspartate ligase Ava_2070 ENOG41082AN stage II sporulation protein Ava_2072 ENOG41082BG Binds together with S18 to 16S ribosomal RNA (By similarity) Ava_2073 ENOG4105ERH Fumarylacetoacetate hydrolase Ava_2076 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Ava_2077 ENOG4105ESV Glycosyl transferase, family 4 Ava_2078 ENOG4105CEV competence damage-inducible protein Ava_2082 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Ava_2084 ENOG4107WDG serine threonine protein kinase Ava_2088 ENOG4105KRQ Addiction module toxin, Txe YoeB family Ava_2090 ENOG4107R4J Chloride channel Ava_2093 ENOG4105D3Q Sugar transferase Ava_2094 ENOG4105DRS transport system, permease Ava_2095 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Ava_2097 ENOG4105C0K Gdp-mannose 4,6-dehydratase Ava_2099 ENOG4105D3Q Sugar transferase Ava_2100 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_2101 ENOG4105CMR udp-glucose 4-epimerase Ava_2103 ENOG4105JZI cytochrome P450 Ava_2104 ENOG4108HMN Caspase domain Ava_2111 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Ava_2112 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Ava_2114 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Ava_2115 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Ava_2116 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Ava_2117 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Ava_2119 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Ava_2124 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Ava_2125 ENOG4108JA2 transcriptioN-repair coupling factor Ava_2130 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase Ava_2131 ENOG4107TVC Glycosyl transferase, family 2 Ava_2134 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Ava_2137 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Ava_2138 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II Ava_2140 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin Ava_2142 ENOG4108Z6B deaminase Ava_2148 ENOG4105BZU Histidine kinase Ava_2149 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_2150 ENOG4105BZU Histidine kinase Ava_2152 ENOG4105BZU Histidine kinase Ava_2153 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_2157 ENOG4105CXN decarboxylase Ava_2162 ENOG4105CMQ Chloride channel Ava_2169 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Ava_2170 ENOG4105ETE Transcriptional regulator (LacI family Ava_2171 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Ava_2172 ENOG4105C2J ABC transporter Ava_2173 ENOG4105CNN ABC, transporter Ava_2176 ENOG4105BZU Histidine kinase Ava_2177 ENOG4105CVJ phosphoglycerate mutase Ava_2183 ENOG4105CNF WD-40 repeat protein Ava_2184 ENOG4108HMN Caspase domain Ava_2189 ENOG4105C0D helicase Ava_2197 ENOG4105DBV ornithine carbamoyltransferase Ava_2210 ENOG4105EYH Exonuclease Ava_2215 ENOG4105C6E dna polymerase iii Ava_2216 ENOG4105KK4 UPF0060 membrane protein Ava_2217 ENOG4105CND Glycosyl transferase, family 2 Ava_2221 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Ava_2226 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Ava_2228 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 Ava_2242 ENOG4105CIH Imidazole acetol-phosphate transaminase Ava_2243 ENOG4105IPS esterase Ava_2244 ENOG4105DC8 reductase Ava_2248 ENOG4105U3E Transcriptional regulator Ava_2251 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ava_2252 ENOG4105DGI Alkaline phosphatase Ava_2254 ENOG4108KQI regulatory protein luxr Ava_2259 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Ava_2260 ENOG4105CUT histidyl-tRNA synthetase Ava_2263 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ava_2265 ENOG4105DKQ ROK family Ava_2267 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Ava_2268 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ava_2273 ENOG4105CIK Amidinotransferase Ava_2278 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Ava_2282 ENOG4105DUM transcriptional regulator, lysR family Ava_2283 ENOG4107STW synthase Ava_2287 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related Ava_2289 ENOG4108UV1 cellular component movement Ava_2293 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Ava_2297 ENOG410823V Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Ava_2298 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Ava_2301 ENOG4105F38 ABC transporter, permease Ava_2302 ENOG4107RUE extracellular solute-binding protein family 1 Ava_2303 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Ava_2304 ENOG4105CJN penicillin-binding protein Ava_2308 ENOG4105C8S subunit m Ava_2311 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Ava_2313 ENOG4107YCR Transcriptional regulator, ARSR family Ava_2314 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Ava_2315 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Ava_2317 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Ava_2318 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Ava_2319 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Ava_2320 ENOG4105DFU Cell wall formation (By similarity) Ava_2321 ENOG4105D4A Cell wall formation (By similarity) Ava_2322 ENOG41082EZ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Ava_2324 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_2325 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Ava_2328 ENOG4105BZU Histidine kinase Ava_2330 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) Ava_2332 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Ava_2335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Ava_2342 ENOG4105EWK phytoene Ava_2347 ENOG4105CPQ Dehydrogenase Ava_2348 ENOG4105D5K Hemolysin activator protein Ava_2352 ENOG4105IB0 filamentous hemagglutinin family outer membrane protein Ava_2354 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) Ava_2356 ENOG4108JQB penicillin-binding protein 1C Ava_2357 ENOG4105DN3 alpha-2-macroglobulin domain protein Ava_2358 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Ava_2361 ENOG4105C37 (CBS) domain Ava_2362 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Ava_2364 ENOG4107T5V SNARE associated Golgi Ava_2367 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Ava_2368 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Ava_2372 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Ava_2380 ENOG4105CVM Molybdenum cofactor synthesis domain protein Ava_2382 ENOG4107RIQ Sulfate adenylate transferase Ava_2388 ENOG4105K64 Glycosyl transferase, family 2 Ava_2391 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ava_2398 ENOG4108JJA ABC, transporter Ava_2401 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Ava_2403 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Ava_2405 ENOG4105MN0 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 Ava_2406 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 Ava_2414 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Ava_2419 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_2420 ENOG4105BZU Histidine kinase Ava_2423 ENOG4105F4R Transcriptional regulator mode Ava_2424 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Ava_2428 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Ava_2430 ENOG4105CJW magnesium transporter Ava_2433 ENOG4107T8Q Glycosyl transferase (Group 1 Ava_2434 ENOG4105E2K Glycosyl transferase (Group 1 Ava_2435 ENOG4105BZ1 (ABC) transporter Ava_2437 ENOG4108PWY Carbohydrate-selective porin OprB Ava_2439 ENOG4105GR3 Histidine kinase Ava_2440 ENOG4105ETX regulatoR Ava_2443 ENOG4105CAU Arsenical resistance protein, ArsH Ava_2444 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ava_2445 ENOG4105VGQ Photosystem I subunit X Ava_2448 ENOG4108UHU Aldolase Ava_2460 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II Ava_2461 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Ava_2467 ENOG4107S17 Phosphate-binding protein Ava_2470 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Ava_2473 ENOG4108JQC penicillin-binding protein 1A Ava_2475 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Ava_2478 ENOG4105C8U phosphate abc transporter Ava_2479 ENOG4105E2Z phosphate ABC transporter (Permease Ava_2480 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ava_2482 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Ava_2483 ENOG4108RXX maleylacetoacetate isomerase Ava_2485 ENOG41084KP 4-oxalocrotonate tautomerase Ava_2489 ENOG4108I6A alcohol dehydrogenase Ava_2492 ENOG4105D2N Aldolase Ava_2502 ENOG4105CBX hi0933 family Ava_2507 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ava_2510 ENOG4108PWY Carbohydrate-selective porin OprB Ava_2511 ENOG4105KZX Pterin carbinolamine dehydratase Ava_2512 ENOG4105D6H One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity) Ava_2513 ENOG4105VUV UPF0367 protein Ava_2514 ENOG4108JJB ABC transporter Ava_2515 ENOG4105M0M Tetracycline resistance protein Ava_2518 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Ava_2519 ENOG4107WDG serine threonine protein kinase Ava_2520 ENOG4105CQB FAD linked oxidase domain protein Ava_2522 ENOG4105F32 YngK protein Ava_2527 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Ava_2532 ENOG4105DRS transport system, permease Ava_2533 ENOG410612X Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane Ava_2535 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Ava_2537 ENOG4105EUJ GTP cyclohydrolase i Ava_2538 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Ava_2539 ENOG4105VGQ Photosystem I subunit X Ava_2540 ENOG4106INZ Photosystem I reaction center subunit Ava_2542 ENOG4108Y85 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) Ava_2545 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Ava_2548 ENOG4108SGK Tetr family transcriptional regulator Ava_2549 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Ava_2552 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Ava_2553 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Ava_2554 ENOG4107Z3D 50S ribosomal protein l10 Ava_2555 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Ava_2561 ENOG4107SBE Glycosyl transferase (Group 1 Ava_2562 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_2563 ENOG4105BZU Histidine kinase Ava_2567 ENOG4106JD1 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity) Ava_2578 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Ava_2579 ENOG4108SMZ Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) Ava_2588 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) Ava_2590 ENOG4108JA1 polyketide synthase Ava_2591 ENOG4105C0W non-ribosomal peptide synthetase Ava_2593 ENOG4107SQU synthase Ava_2594 ENOG4107QKG PfaD family Ava_2595 ENOG4107P5I polyketide synthase Ava_2596 ENOG4108W6C Dehydrogenase Ava_2599 ENOG4108JQ9 ABC transporter Ava_2605 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ava_2610 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Ava_2611 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Ava_2612 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Ava_2613 ENOG4105VYJ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Ava_2614 ENOG4105S30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Ava_2615 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Ava_2616 ENOG4107SM1 it plays a direct role in the translocation of protons across the membrane (By similarity) Ava_2617 ENOG4105PA3 atp synthase Ava_2618 ENOG4107SWE Methyltransferase Ava_2620 ENOG4105EEK Polypeptide Ava_2621 ENOG4108MAQ allophycocyanin alpha Ava_2622 ENOG4105FBM allophycocyanin beta subunit Ava_2623 ENOG4105W5K Rod linker protein, associated with allophycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer (By similarity) Ava_2624 ENOG41063JG Transcriptional regulator Ava_2629 ENOG4105CNF WD-40 repeat protein Ava_2631 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Ava_2632 ENOG4105E4F Isochorismate synthase Ava_2647 ENOG4108ISE 4Fe-4S ferredoxin, iron-sulfur binding Ava_2653 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Ava_2654 ENOG4105K63 Thioredoxin Ava_2660 ENOG4105C5I Dehydrogenase Ava_2661 ENOG4107YJ4 chain length determinant protein Ava_2665 ENOG41082QS Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Ava_2668 ENOG4105DHP deoxycytidine triphosphate deaminase Ava_2670 ENOG4106QP8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Ava_2671 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Ava_2673 ENOG4105DHJ ABC, transporter Ava_2675 ENOG4105BZU Histidine kinase Ava_2678 ENOG4105N7N Pentapeptide repeat-containing protein Ava_2679 ENOG4108KGH TRANSCRIPTIONal Ava_2682 ENOG4105CJ1 ABC, transporter Ava_2684 ENOG4105D9P serine threonine protein kinase Ava_2692 ENOG4105C8M UPF0272 protein Ava_2693 ENOG4107RTD sua5 ycio yrdc ywlc family protein Ava_2696 ENOG4105C9U ATP-dependent DNA helicase RecQ Ava_2701 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) Ava_2703 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Ava_2709 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Ava_2714 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Ava_2715 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_2716 ENOG4107YX3 NADH dehydrogenase subunit j Ava_2717 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_2718 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Ava_2723 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Ava_2727 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Ava_2728 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Ava_2729 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Ava_2731 ENOG4105CEY Amp-dependent synthetase and ligase Ava_2736 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ava_2745 ENOG4105H0N Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I Ava_2746 ENOG4108UQX Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity) Ava_2748 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ava_2751 ENOG4108UXN response regulator Ava_2754 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_2759 ENOG4105N7N Pentapeptide repeat-containing protein Ava_2760 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Ava_2761 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Ava_2762 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Ava_2764 ENOG4105CMS peptidase U62, modulator of DNA gyrase Ava_2777 ENOG4107RAQ aminopeptidase Ava_2780 ENOG4105DDQ anthranilate synthase Ava_2782 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Ava_2787 ENOG4105C22 threonyL-tRNA synthetase Ava_2788 ENOG4105CNF WD-40 repeat protein Ava_2790 ENOG4105CK2 sodium dicarboxylate symporter Ava_2791 ENOG4105D9P serine threonine protein kinase Ava_2794 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Ava_2796 ENOG4105C8S subunit m Ava_2798 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Ava_2801 ENOG4105DTD Dehydrogenase Ava_2803 ENOG4105D9P serine threonine protein kinase Ava_2804 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Ava_2813 ENOG410834F Transcriptional regulator Ava_2817 ENOG4105CNF WD-40 repeat protein Ava_2819 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Ava_2820 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Ava_2821 ENOG4108E2B had-superfamily hydrolase, subfamily iib Ava_2823 ENOG4105D9N nucleoside Ava_2824 ENOG4107Z12 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Ava_2825 ENOG4105C72 UPF0176 protein Ava_2828 ENOG4105S6R Iron-hydroxamate transporter permease subunit Ava_2829 ENOG4105J76 Periplasmic binding protein Ava_2830 ENOG4105E0A ABC, transporter Ava_2838 ENOG4105DY8 decarboxylase Ava_2843 ENOG410902K Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Ava_2845 ENOG4105D9P serine threonine protein kinase Ava_2852 ENOG4105C19 ABC transporter Ava_2859 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ava_2860 ENOG4105C19 ABC transporter Ava_2861 ENOG4105D0S secretion protein (HlyD Ava_2862 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ava_2865 ENOG4105DVK Precorrin-2 c20-methyltransferase Ava_2866 ENOG41081F0 Precorrin-8x methylmutase Ava_2867 ENOG4105J0C Ava_2868 ENOG4108RMU ferritin dps family protein Ava_2869 ENOG4105CHR reductase Ava_2874 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Ava_2875 ENOG41068BY Low temperature-induced protein Ava_2888 ENOG4105EMU Dehydrogenase Ava_2890 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Ava_2896 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Ava_2897 ENOG4107U45 Cobalt transport protein Ava_2900 ENOG41080W8 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Ava_2902 ENOG4105CQR helicase Ava_2907 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Ava_2914 ENOG4105DXN mazG family Ava_2916 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_2917 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Ava_2919 ENOG4105D7K pfkb domain protein Ava_2925 ENOG4106KF1 Phycobilisome protein Ava_2928 ENOG41078GB pbs lyase Ava_2929 ENOG4106TM1 PBS lyase HEAT-like repeat Ava_2930 ENOG4105D6V phycocyanin beta subunit Ava_2931 ENOG4108SDR phycocyanin, alpha subunit Ava_2932 ENOG4108MZQ phycobilisome linker polypeptide Ava_2934 ENOG41078GB pbs lyase Ava_2935 ENOG4108V9J phycocyanobilin lyase Ava_2936 ENOG4106BTU phycobilisome rod-core linker polypeptide Ava_2937 ENOG4106BTU phycobilisome rod-core linker polypeptide Ava_2939 ENOG4106Q05 Rod-core linker protein required for attachment of phycocyanin to allophycocyanin in cores of phycobilisomes (By similarity) Ava_2940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ava_2942 ENOG4105C26 Dehydrogenase Ava_2944 ENOG4105BZU Histidine kinase Ava_2945 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Ava_2947 ENOG4105D4Y metalloprotease Ava_2949 ENOG4107RAJ Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Ava_2952 ENOG4105CE4 GlcNAc 6-P deacetylase Ava_2956 ENOG4105BZU Histidine kinase Ava_2960 ENOG4105E90 ABC transporter Ava_2961 ENOG4108IJ8 ABC transporter Ava_2965 ENOG4105CHR reductase Ava_2976 ENOG41087WU Ava_2981 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Ava_2982 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Ava_2987 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Ava_2989 ENOG4108V5V Serine Threonine protein kinase Ava_2990 ENOG4108V5V Serine Threonine protein kinase Ava_2993 ENOG4105C31 Tryptophanyl-tRNA synthetase Ava_3000 ENOG4105EVB acetyltransferase Ava_3005 ENOG4108UXN response regulator Ava_3006 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Ava_3009 ENOG4105BZU Histidine kinase Ava_3015 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) Ava_3017 ENOG4105BZ1 (ABC) transporter Ava_3020 ENOG4105C5H ABC transporter Ava_3022 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Ava_3025 ENOG4105D9U N-acetyltransferase Ava_3026 ENOG4105CHH sulfate transporter Ava_3033 ENOG4105BZU Histidine kinase Ava_3034 ENOG41083MR nifu domain-containing protein Ava_3037 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Ava_3044 ENOG4107R1X phosphohexokinase Ava_3045 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Ava_3046 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Ava_3051 ENOG4107SC1 transglycosylase Ava_3064 ENOG4108K7V UPF0284 protein Ava_3066 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Ava_3071 ENOG4105DU0 nucleoside hydrolase Ava_3073 ENOG4105C0H protease Ava_3074 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Ava_3076 ENOG4105VN1 Heat shock protein Ava_3077 ENOG4105KPY Small multidrug resistance protein Ava_3078 ENOG4108HMN Caspase domain Ava_3079 ENOG4108HMN Caspase domain Ava_3081 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Ava_3085 ENOG4105WVZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_3086 ENOG4105CKD glutathione-regulated potassium-efflux system protein Ava_3088 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Ava_3089 ENOG4105BZU Histidine kinase Ava_3091 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Ava_3096 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ava_3100 ENOG4105CPC Aldo Keto reductase Ava_3106 ENOG4105E2X shikimate dehydrogenase Ava_3109 ENOG4108VIA integral membrane protein Ava_3111 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Ava_3115 ENOG4107S2Z UPF0761 membrane protein Ava_3118 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Ava_3119 ENOG4108UYE Lactoylglutathione lyase Ava_3128 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Ava_3132 ENOG4105VFU Rna-binding protein Ava_3133 ENOG4105CSR polyphosphate kinase 2 Ava_3135 ENOG4105RYY domain protein Ava_3138 ENOG4105D3G Pseudouridine synthase Ava_3146 ENOG4105D0M Protease HtpX homolog Ava_3150 ENOG4105CRK lysyL-tRNA synthetase Ava_3159 ENOG4105BZU Histidine kinase Ava_3166 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Ava_3171 ENOG4105BZU Histidine kinase Ava_3173 ENOG4108IQE Amp-dependent synthetase and ligase Ava_3178 ENOG4108SHJ s-layer protein Ava_3180 ENOG4108NAW Type II site-specific deoxyribonuclease Ava_3186 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Ava_3187 ENOG4105IJJ transcriptional regulator, crp fnr family Ava_3188 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Ava_3192 ENOG4105DGU Histone deacetylase Ava_3193 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) Ava_3195 ENOG4108K5P (LipO)protein Ava_3196 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Ava_3197 ENOG4105D0M Protease HtpX homolog Ava_3198 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_3204 ENOG4105G5N sensor protein Ava_3207 ENOG4105BZU Histidine kinase Ava_3208 ENOG4108PJD permease Ava_3219 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Ava_3227 ENOG4105C12 Phosphoribosylglycinamide synthetase Ava_3228 ENOG4108IAJ Nad-dependent epimerase dehydratase Ava_3230 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Ava_3231 ENOG4106YN8 Prenyltransferase Ava_3232 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Ava_3234 ENOG4105BZU Histidine kinase Ava_3243 ENOG4105VDM plasmid maintenance system antidote protein, xre family Ava_3248 ENOG4105E6M Sulphatase-modifying factor protein Ava_3267 ENOG4107QTH restriction modification system DNA specificity domain Ava_3273 ENOG4108F3G Type I restriction-modification system, R subunit Ava_3275 ENOG4105CNF WD-40 repeat protein Ava_3275 ENOG4105CNF WD-40 repeat protein Ava_3277 ENOG4105C0D helicase Ava_3279 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Ava_3282 ENOG4108R0D protein with myosin-like Ava_3283 ENOG4107RU9 Transcriptional regulator, Crp Fnr family Ava_3284 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Ava_3285 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Ava_3286 ENOG4105DA5 (ABC) transporter Ava_3290 ENOG4105CP7 Triose-phosphate isomerase Ava_3291 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Ava_3297 ENOG4105D52 delta-aminolevulinic acid dehydratase Ava_3298 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Ava_3299 ENOG4105D0M Protease HtpX homolog Ava_3301 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_3303 ENOG4105F23 Fibronectin-binding protein Ava_3305 ENOG4105ERG peptidase m48, ste24p Ava_3306 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Ava_3308 ENOG4107WDG serine threonine protein kinase Ava_3310 ENOG4107WDG serine threonine protein kinase Ava_3311 ENOG4105CTK cobaltochelatase, cobn subunit Ava_3327 ENOG4107TCE N-acetyltransferase Ava_3330 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Ava_3332 ENOG4105XCI PucC protein Ava_3333 ENOG4105ECY inositol monophosphatase Ava_3338 ENOG4105CHR reductase Ava_3340 ENOG4105IJJ transcriptional regulator, crp fnr family Ava_3341 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase Ava_3342 ENOG4105D0U Arsenite-activated ATPase (ArsA) Ava_3347 ENOG4105EY8 ABC transporter Ava_3348 ENOG4107RGC Glycosyl transferase, family 2 Ava_3349 ENOG4107RGC Glycosyl transferase, family 2 Ava_3351 ENOG4105CKK Glycosyl transferase, family 2 Ava_3352 ENOG4108IAJ Nad-dependent epimerase dehydratase Ava_3354 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Ava_3355 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Ava_3356 ENOG4107V9E glucose-1-phosphate thymidylyltransferase Ava_3359 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Ava_3360 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_3362 ENOG4105BZU Histidine kinase Ava_3365 ENOG4108PWY Carbohydrate-selective porin OprB Ava_3366 ENOG4108W3Y Transcriptional regulator, Crp Fnr family Ava_3368 ENOG4105EB3 Histidine kinase Ava_3369 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_3372 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Ava_3377 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Ava_3378 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Ava_3382 ENOG4108ZF3 Phosphatase Ava_3386 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Ava_3388 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ava_3389 ENOG4108302 MgtC SapB transporter Ava_3391 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Ava_3392 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Ava_3393 ENOG4108KS2 transglutaminase domain protein Ava_3397 ENOG4105CKK Glycosyl transferase, family 2 Ava_3398 ENOG4105C6X Major Facilitator Ava_3399 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Ava_3402 ENOG410812K response regulator receiver protein Ava_3407 ENOG4107QRP cobalamin biosynthesis protein CobW Ava_3411 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_3418 ENOG4105E0Y RtcB Protein Ava_3419 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Ava_3423 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Ava_3424 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Ava_3425 ENOG4107TS3 membrane protein, TerC Ava_3428 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Ava_3429 ENOG4105W8H transhydrogenase (subunit alpha Ava_3430 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Ava_3433 ENOG41082ZZ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Ava_3435 ENOG4107RIX inner membrane protein translocase component YidC Ava_3441 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Ava_3442 ENOG4108R6B Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Ava_3444 ENOG4105C0K Gdp-mannose 4,6-dehydratase Ava_3445 ENOG4105JNK Glycosyl transferase (Group 1 Ava_3447 ENOG41084A0 50s ribosomal protein L35 Ava_3448 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Ava_3453 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_3455 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Ava_3459 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Ava_3460 ENOG4107QN2 dihydrolipoyl dehydrogenase Ava_3464 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Ava_3466 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) Ava_3467 ENOG4105BZU Histidine kinase Ava_3474 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Ava_3477 ENOG4107XW6 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Ava_3479 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Ava_3481 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Ava_3484 ENOG4108Z6M essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn Ava_3492 ENOG4108R5Z fruiting body developmental protein Ava_3493 ENOG4108YN7 fruiting body developmental protein Ava_3498 ENOG4105CVR type I restriction-modification system Ava_3498 ENOG4105CVR type I restriction-modification system Ava_3502 ENOG4105DZR Type I site-specific deoxyribonuclease Ava_3510 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Ava_3512 ENOG4107S8C mandelate racemase muconate lactonizing Ava_3516 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Ava_3517 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Ava_3519 ENOG4105DWF phosphomethylpyrimidine kinase Ava_3526 ENOG4105BZU Histidine kinase Ava_3530 ENOG4105C9X ppx gppa phosphatase Ava_3533 ENOG4105C7K acetolactate synthase Ava_3535 ENOG4105D9P serine threonine protein kinase Ava_3536 ENOG4108JUA Transcriptional regulator Ava_3539 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Ava_3541 ENOG4105BZU Histidine kinase Ava_3544 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Ava_3546 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Ava_3547 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Ava_3548 ENOG4105F0N pyrophosphate phospho-hydrolase Ava_3553 ENOG4105EY5 This is one of the two reaction center proteins of photosystem II Ava_3554 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Ava_3556 ENOG4108IJ0 Aspartate ammonia-lyase Ava_3558 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Ava_3561 ENOG4105C75 arginyL-tRNA synthetase Ava_3569 ENOG4105CPK Glycosyl transferase (Group 1 Ava_3573 ENOG4105E2K Glycosyl transferase (Group 1 Ava_3582 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Ava_3584 ENOG4105D9P serine threonine protein kinase Ava_3585 ENOG4105E67 Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings) Ava_3588 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Ava_3594 ENOG4105D64 Mechanosensitive ion channel Ava_3595 ENOG4105D64 Mechanosensitive ion channel Ava_3603 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Ava_3604 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ava_3605 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Ava_3607 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Ava_3609 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Ava_3613 ENOG41068G9 50S ribosomal protein L32 Ava_3615 ENOG4105C26 Dehydrogenase Ava_3616 ENOG4105BZU Histidine kinase Ava_3618 ENOG4105CQM Urea amidohydrolase subunit alpha Ava_3620 ENOG4105KI2 Urea amidohydrolase subunit beta Ava_3621 ENOG4108YZ9 Urea amidohydrolase subunit gamma Ava_3622 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Ava_3626 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Ava_3627 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Ava_3630 ENOG4105C5S asparaginyl-tRNA synthetase Ava_3634 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Ava_3635 ENOG4108S1Y allophycocyanin alpha-B chain Ava_3636 ENOG4107QIK phosphoribosylformylglycinamidine synthase Ava_3637 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Ava_3642 ENOG4105CFH Aspartokinase Ava_3645 ENOG4105CV1 Transketolase (EC 2.2.1.1) Ava_3647 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Ava_3648 ENOG41086B8 CoB-CoM heterodisulfide reductase Ava_3649 ENOG41086BQ Protein CrcB homolog Ava_3651 ENOG4105CVJ phosphoglycerate mutase Ava_3653 ENOG4108IAJ Nad-dependent epimerase dehydratase Ava_3658 ENOG4107QRT dEAD DEAH box helicase Ava_3660 ENOG4105CZX twitching motility protein Ava_3661 ENOG4108ZGN Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity) Ava_3669 ENOG4105BZU Histidine kinase Ava_3681 ENOG4108Z0R Transferase Ava_3683 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Ava_3689 ENOG4105GVR general secretion pathway protein D Ava_3693 ENOG4105DJZ UPF0182 protein Ava_3695 ENOG4105CHM Aminotransferase Ava_3697 ENOG4105CBT Fructose-1,6-bisphosphatase Ava_3699 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Ava_3702 ENOG4107YCR Transcriptional regulator, ARSR family Ava_3704 ENOG4105C0Z ABC transporter Ava_3705 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Ava_3708 ENOG4105C89 phosphohexose isomerase Ava_3715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Ava_3717 ENOG4105CKI cobalamin synthesis protein Ava_3718 ENOG4105C8N cysteinyl-tRNA synthetase Ava_3720 ENOG4105CMS peptidase U62, modulator of DNA gyrase Ava_3721 ENOG4105BZU Histidine kinase Ava_3722 ENOG41082AN stage II sporulation protein Ava_3723 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_3728 ENOG4105MSA Photosystem II reaction center W protein Ava_3730 ENOG4105C8Y Acetylornithine aminotransferase Ava_3732 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Ava_3734 ENOG4105FDP GntR family transcriptional regulator Ava_3735 ENOG4105F8J Adenylate Guanylate cyclase Ava_3741 ENOG4105DGI Alkaline phosphatase Ava_3745 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Ava_3747 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Ava_3752 ENOG4105C71 hydrolase family 65, central catalytic Ava_3753 ENOG4107STW synthase Ava_3755 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Ava_3760 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Ava_3765 ENOG4105ESV Glycosyl transferase, family 4 Ava_3766 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Ava_3767 ENOG4105EWN Heme oxygenase Ava_3769 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Ava_3770 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP Ava_3772 ENOG4107QJE Chromosome Partitioning Protein Ava_3774 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Ava_3775 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Ava_3776 ENOG4105M3Z response regulator Ava_3779 ENOG4105CBS Chea signal transduction histidine kinase Ava_3781 ENOG4105EUB pirin domain protein Ava_3782 ENOG4107XNQ Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Ava_3783 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit Ava_3784 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Ava_3797 ENOG41089UC methyltransferase, type 11 Ava_3798 ENOG4105CJ3 phosphate transporter Ava_3804 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Ava_3806 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Ava_3807 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Ava_3818 ENOG4105DC1 bifunctional purine biosynthesis protein purh Ava_3819 ENOG4105BZU Histidine kinase Ava_3821 ENOG4105WEF catalase Ava_3822 ENOG4105Y3U Transglycosylase-associated protein Ava_3823 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Ava_3824 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Ava_3833 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Ava_3835 ENOG41072GX Peptidase M22 Glycoprotease Ava_3836 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Ava_3843 ENOG4107CUI carotenoid binding protein Ava_3846 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Ava_3848 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_3849 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_3850 ENOG4105ES5 Histidine kinase Ava_3852 ENOG4105BZU Histidine kinase Ava_3858 ENOG4108KK4 3-dehydroquinate synthase Ava_3859 ENOG4105C59 p-type ATPase Ava_3860 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Ava_3862 ENOG41081F0 Precorrin-8x methylmutase Ava_3863 ENOG4105DSF transport protein Ava_3865 ENOG4105BZU Histidine kinase Ava_3866 ENOG4105KAN Probably a ribosomal protein or a ribosome-associated protein (By similarity) Ava_3868 ENOG4105BZU Histidine kinase Ava_3875 ENOG4106WTF Glycosyl transferase, family 2 Ava_3876 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF Ava_3880 ENOG4107YBR Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Ava_3881 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Ava_3883 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Ava_3886 ENOG4105E5Q amino acid AbC transporter Ava_3890 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Ava_3891 ENOG4108PPB Seems to be required for the assembly of the photosystem I complex (By similarity) Ava_3892 ENOG4108RAV Conserved protein Ava_3893 ENOG4108K3A Glutathione S-transferase Ava_3894 ENOG41063C6 UPF0235 protein Ava_3897 ENOG4105H0Z Hemerythrin HHE cation binding domain protein Ava_3903 ENOG41067S7 ribulose bisphosphate carboxylase Ava_3905 ENOG4108VFZ ribulose bisphosphate carboxylase, small Ava_3907 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Ava_3909 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Ava_3911 ENOG4107R7I amino acid Ava_3913 ENOG4108AC1 4fe-4s ferredoxin, iron-sulfur binding Ava_3914 ENOG4105C3J Cysteine desulfurase Ava_3916 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Ava_3917 ENOG4105D0B Nitrogenase protein alpha chain Ava_3921 ENOG4105JZI cytochrome P450 Ava_3922 ENOG4108S59 Ava_3929 ENOG4105D0B Nitrogenase protein alpha chain Ava_3930 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain Ava_3932 ENOG4105D0B Nitrogenase protein alpha chain Ava_3933 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN Ava_3934 ENOG4108UR2 Nitrogen fixation protein NifX Ava_3935 ENOG4108VQE nitrogen fixation protein Ava_3936 ENOG4105X87 nitrogen fixation Ava_3937 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) Ava_3938 ENOG41081QJ UBA THIF-type NAD FAD binding Ava_3939 ENOG4105V5Z Iron-sulfur cluster assembly accessory protein Ava_3942 ENOG4105F4R Transcriptional regulator mode Ava_3952 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Ava_3956 ENOG4107S73 homocitrate synthase Ava_3963 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Ava_3966 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Ava_3967 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Ava_3968 ENOG4108W6C Dehydrogenase Ava_3969 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Ava_3970 ENOG4108RU0 short-chain dehydrogenase reductase Ava_3975 ENOG4105BZU Histidine kinase Ava_3976 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_3980 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Ava_3985 ENOG4107EEY synthase Ava_3987 ENOG4105CEY Amp-dependent synthetase and ligase Ava_3988 ENOG4105C84 Histidine ammonia-lyase Ava_3995 ENOG4105D9P serine threonine protein kinase Ava_3996 ENOG4105CGH 5'-nucleotidase Ava_4009 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin Ava_4014 ENOG4105DFK Polyphosphate glucokinase Ava_4016 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Ava_4017 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Ava_4018 ENOG4106H78 methyltransferase Ava_4023 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Ava_4024 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Ava_4026 ENOG4105D0B Nitrogenase protein alpha chain Ava_4027 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain Ava_4028 ENOG4105D0B Nitrogenase protein alpha chain Ava_4035 ENOG4108DBC nitroreductase Ava_4037 ENOG4105XEA Tetr family transcriptional regulator Ava_4038 ENOG4108JJB ABC transporter Ava_4041 ENOG4107S73 homocitrate synthase Ava_4042 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Ava_4047 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Ava_4048 ENOG4105C4M (Ubiquinol oxidase) subunit I Ava_4051 ENOG4105D0B Nitrogenase protein alpha chain Ava_4052 ENOG4108UR2 Nitrogen fixation protein NifX Ava_4058 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein Ava_4059 ENOG4108PWY Carbohydrate-selective porin OprB Ava_4063 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Ava_4065 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Ava_4066 ENOG4105GVF (ABC) transporter Ava_4076 ENOG4107QT6 homoserine O-acetyltransferase Ava_4077 ENOG4108IQK o-acetylhomoserine Ava_4078 ENOG41066VF YeeE YedE family protein Ava_4079 ENOG4105KHC sulfurtransferase Ava_4086 ENOG4105BZU Histidine kinase Ava_4095 ENOG4107S1Q Phosphatase Ava_4105 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Ava_4108 ENOG4108JA1 polyketide synthase Ava_4110 ENOG4108HMN Caspase domain Ava_4111 ENOG4108V1U phospholipid-binding protein Ava_4113 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Ava_4114 ENOG4107RA9 decarboxylase Ava_4115 ENOG4105D82 Glutamate dehydrogenase Ava_4121 ENOG4108NSV This is one of the two reaction center proteins of photosystem II Ava_4123 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Ava_4130 ENOG4105DGI Alkaline phosphatase Ava_4136 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ava_4138 ENOG4105E2Y ABC, transporter Ava_4139 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Ava_4140 ENOG4108PWY Carbohydrate-selective porin OprB Ava_4141 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Ava_4142 ENOG4105CPU Monooxygenase Ava_4145 ENOG4105CPC Aldo Keto reductase Ava_4146 ENOG4105GVF (ABC) transporter Ava_4147 ENOG4105BZ1 (ABC) transporter Ava_4148 ENOG4107UWC ABC, transporter Ava_4153 ENOG4108DBC nitroreductase Ava_4154 ENOG4105GVF (ABC) transporter Ava_4155 ENOG4105C28 cystathionine Ava_4157 ENOG4105CHM Aminotransferase Ava_4163 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ava_4169 ENOG4105DFS Conserved Protein Ava_4176 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Ava_4177 ENOG41066GP CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Ava_4182 ENOG4105D5K Hemolysin activator protein Ava_4190 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Ava_4200 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Ava_4203 ENOG4107YZX Universal stress protein Ava_4204 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Ava_4205 ENOG41084H8 Binds directly to 16S ribosomal RNA (By similarity) Ava_4207 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Ava_4208 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Ava_4209 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Ava_4213 ENOG4105CXI aluminum resistance protein Ava_4214 ENOG4106I2R Coenzyme F420 hydrogenase dehydrogenase, beta Ava_4215 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Ava_4216 ENOG4105Q36 FHA domain containing protein Ava_4222 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Ava_4225 ENOG4108JJA ABC, transporter Ava_4226 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ava_4228 ENOG4107GBW cellulosome anchoring protein cohesin Ava_4230 ENOG4105CJ1 ABC, transporter Ava_4235 ENOG4105C59 p-type ATPase Ava_4237 ENOG4107SWG transcriptional regulator MERR family Ava_4238 ENOG4105C5I Dehydrogenase Ava_4239 ENOG4105E6M Sulphatase-modifying factor protein Ava_4240 ENOG41061MV Arylsulfatase Ava_4244 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB Ava_4245 ENOG4105C3J Cysteine desulfurase Ava_4247 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Ava_4249 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain Ava_4251 ENOG4105D0B Nitrogenase protein alpha chain Ava_4252 ENOG4108UR2 Nitrogen fixation protein NifX Ava_4253 ENOG4108VQE nitrogen fixation protein Ava_4254 ENOG4105X87 nitrogen fixation Ava_4255 ENOG4106C8Q May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) Ava_4256 ENOG41081QJ UBA THIF-type NAD FAD binding Ava_4257 ENOG4108Z4V iron-sulfur cluster assembly Ava_4259 ENOG4105WCA Ferredoxin Ava_4264 ENOG4107QRI Phosphoketolase Ava_4276 ENOG4108JYK Dehydrogenase Ava_4280 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Ava_4281 ENOG41067HS methyltransferase Ava_4287 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_4291 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Ava_4293 ENOG4108UXN response regulator Ava_4295 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Ava_4303 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Ava_4307 ENOG4105N7N Pentapeptide repeat-containing protein Ava_4308 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Ava_4310 ENOG4105C1V Peptidase, M16 Ava_4312 ENOG41086DT Membrane protein of unknown function Ava_4319 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Ava_4321 ENOG4105NAE bifunctional deaminase-reductase domain protein Ava_4322 ENOG4105VPX protein, conserved in bacteria Ava_4325 ENOG4105BZU Histidine kinase Ava_4326 ENOG4105ES5 Histidine kinase Ava_4328 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Ava_4330 ENOG4105CPU Monooxygenase Ava_4333 ENOG4107XGZ Hydrolase Ava_4334 ENOG4105CIH Imidazole acetol-phosphate transaminase Ava_4335 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Ava_4336 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit Ava_4342 ENOG4105BZ1 (ABC) transporter Ava_4345 ENOG4105BZU Histidine kinase Ava_4345 ENOG4105BZU Histidine kinase Ava_4346 ENOG4107WMZ Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Ava_4348 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Ava_4350 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) Ava_4355 ENOG4105VCC 30S ribosomal protein S21 Ava_4357 ENOG41082B1 30S ribosomal protein S16 Ava_4361 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein Ava_4362 ENOG4105C32 Amino acid ABC transporter (Permease) Ava_4364 ENOG4105C0Z ABC transporter Ava_4365 ENOG4108IV0 ABC, transporter Ava_4366 ENOG4107RAQ aminopeptidase Ava_4367 ENOG4107TIF Phenazine biosynthesis protein, PhzF family Ava_4371 ENOG4105C1V Peptidase, M16 Ava_4381 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Ava_4385 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Ava_4386 ENOG4105D49 3-dehydroquinate synthase Ava_4389 ENOG4107QSQ Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Ava_4391 ENOG4105D9P serine threonine protein kinase Ava_4401 ENOG4105BZU Histidine kinase Ava_4408 ENOG4107RNB anthranilate phosphoribosyltransferase Ava_4410 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Ava_4411 ENOG41082AN stage II sporulation protein Ava_4415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Ava_4416 ENOG4107Z8Z Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Ava_4423 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Ava_4424 ENOG41084UD rubredoxin Ava_4425 ENOG4105BZU Histidine kinase Ava_4426 ENOG4105D5K Hemolysin activator protein Ava_4427 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Ava_4431 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_4432 ENOG4105BZU Histidine kinase Ava_4433 ENOG4105BZU Histidine kinase Ava_4435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Ava_4436 ENOG4105FAV ABC, transporter Ava_4438 ENOG4105FDK ABC transporter Ava_4439 ENOG4105DSE periplasmic solute binding protein Ava_4440 ENOG4108PWY Carbohydrate-selective porin OprB Ava_4447 ENOG410848W 30S ribosomal protein S21 Ava_4448 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Ava_4449 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Ava_4450 ENOG4105WIA photosystem II reaction center protein H Ava_4451 ENOG410686T photosystem II reaction center protein N Ava_4455 ENOG4105E5G Alpha beta hydrolase fold Ava_4457 ENOG4105BZU Histidine kinase Ava_4463 ENOG4107U7Q Transfers the fatty acyl group on membrane lipoproteins (By similarity) Ava_4466 ENOG4105DUM transcriptional regulator, lysR family Ava_4468 ENOG4105MN7 Carbon dioxide concentrating mechanism protein Ava_4469 ENOG4105MXK Carbon dioxide concentrating mechanism protein Ava_4470 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml Ava_4471 ENOG4108WT6 Carbon dioxide concentrating mechanism protein Ava_4473 ENOG4105D65 subunit l Ava_4474 ENOG4105C8S subunit m Ava_4478 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Ava_4481 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Ava_4484 ENOG4105DGW oligopeptidase A Ava_4488 ENOG4107JEG This protein is a component of the reaction center of photosystem II (By similarity) Ava_4489 ENOG4105D9P serine threonine protein kinase Ava_4491 ENOG4105E66 phosphoriboisomerase A Ava_4496 ENOG4108Z0Z intracellular protease Pfpi family Ava_4504 ENOG4105D9P serine threonine protein kinase Ava_4506 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Ava_4507 ENOG4105KHC sulfurtransferase Ava_4508 ENOG4105DFS Conserved Protein Ava_4509 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Ava_4511 ENOG4105DX0 Hemolysin A Ava_4512 ENOG4108UMY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ava_4513 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ava_4514 ENOG4105E2Z phosphate ABC transporter (Permease Ava_4515 ENOG4105C8U phosphate abc transporter Ava_4516 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Ava_4517 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Ava_4518 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_4532 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Ava_4534 ENOG4108I0Q anthranilate phosphoribosyltransferase Ava_4535 ENOG4105F04 LysR family Transcriptional regulator Ava_4536 ENOG4108PWY Carbohydrate-selective porin OprB Ava_4540 ENOG4105I5W Transporter Ava_4543 ENOG4105D7T ABC transporter Ava_4544 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Ava_4549 ENOG4108P5B Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) Ava_4553 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Ava_4555 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Ava_4556 ENOG4105CQB FAD linked oxidase domain protein Ava_4572 ENOG4105BZ1 (ABC) transporter Ava_4577 ENOG4108R9R May be involved in photosynthetic membrane biogenesis (By similarity) Ava_4578 ENOG4105D7V transposase Ava_4579 ENOG4108YH8 Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity) Ava_4581 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Ava_4584 ENOG4105CNI cell division protein FtsW Ava_4588 ENOG4108IAJ Nad-dependent epimerase dehydratase Ava_4589 ENOG4105C6Y Udp-glucose 6-dehydrogenase Ava_4590 ENOG4108Z66 YbaK ebsC protein Ava_4595 ENOG4105DPX Hydrogenase, large subunit Ava_4602 ENOG4105C8H hydrogenase maturation protein Hypf Ava_4603 ENOG41082MF Hydrogenase assembly chaperone hypC hupF Ava_4604 ENOG4105CQS hydrogenase expression formation protein HypD Ava_4606 ENOG4105C45 hydrogenase expression formation protein (HypE) Ava_4607 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Ava_4608 ENOG4107RSS Hydrogenase accessory protein HypB Ava_4612 ENOG4107SCA Formamidase (EC 3.5.1.49) Ava_4612 ENOG4107SCA Formamidase (EC 3.5.1.49) Ava_4616 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Ava_4620 ENOG4105CJN penicillin-binding protein Ava_4625 ENOG4105C3G gtp-binding protein Ava_4629 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Ava_4630 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Ava_4631 ENOG4105BZU Histidine kinase Ava_4634 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Ava_4635 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Ava_4637 ENOG4105C3M thioredoxin reductase Ava_4639 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) Ava_4641 ENOG4105EPW hflc protein Ava_4642 ENOG4105VFU Rna-binding protein Ava_4643 ENOG410848W 30S ribosomal protein S21 Ava_4644 ENOG4105XUP Phage derived protein Gp49-like (DUF891) Ava_4645 ENOG4105F8J Adenylate Guanylate cyclase Ava_4647 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Ava_4649 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Ava_4651 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Ava_4654 ENOG4107QIZ NADH dehydrogenase Ava_4657 ENOG4108IEH NADH dehydrogenase subunit g Ava_4659 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ava_4664 ENOG4105CD5 CoA-binding domain protein Ava_4667 ENOG4105EMU Dehydrogenase Ava_4678 ENOG4105XEV csbD-like Ava_4680 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Ava_4681 ENOG4108V5V Serine Threonine protein kinase Ava_4693 ENOG4105CYM Glutathione S-transferase Ava_4696 ENOG4105BZU Histidine kinase Ava_4698 ENOG4105F8J Adenylate Guanylate cyclase Ava_4699 ENOG4107SBE Glycosyl transferase (Group 1 Ava_4701 ENOG4105BZU Histidine kinase Ava_4702 ENOG4105BZU Histidine kinase Ava_4706 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Ava_4708 ENOG4108MUZ hydrolase Ava_4713 ENOG4107Z6A sulfate abc transporter permease Ava_4714 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Ava_4715 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Ava_4720 ENOG4105E7A Glutamine amidotransferase Ava_4722 ENOG4108XKD photosystem i Ava_4723 ENOG4105BZU Histidine kinase Ava_4727 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Ava_4735 ENOG4105BZS acriflavin resistance protein Ava_4740 ENOG4105SUT Transcriptional Regulator AraC Family Ava_4741 ENOG4107SQU synthase Ava_4744 ENOG4108JA1 polyketide synthase Ava_4745 ENOG4108JA1 polyketide synthase Ava_4747 ENOG4108JA1 polyketide synthase Ava_4751 ENOG4107QKG PfaD family Ava_4754 ENOG4108ZAF Molybdopterin Ava_4756 ENOG4108K5P (LipO)protein Ava_4758 ENOG4105CHR reductase Ava_4759 ENOG4108TVJ Nitroreductase Ava_4760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Ava_4761 ENOG4105K63 Thioredoxin Ava_4762 ENOG4105YVS arsR family transcriptional regulator Ava_4774 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Ava_4775 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Ava_4776 ENOG41066AK Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) Ava_4779 ENOG4105BZU Histidine kinase Ava_4780 ENOG4105CHR reductase Ava_4781 ENOG4105BZU Histidine kinase Ava_4782 ENOG4107Z5C methylesterase Ava_4783 ENOG4105BZU Histidine kinase Ava_4784 ENOG4107YD0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Ava_4786 ENOG4105MKQ Monovalent cation H antiporter subunit C Ava_4787 ENOG4108JPZ Monovalent cation H antiporter subunit D Ava_4797 ENOG4108ZJ4 polysaccharide deacetylase Ava_4800 ENOG41083KH UPF0102 protein Ava_4802 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Ava_4804 ENOG4107ZYR domain protein Ava_4805 ENOG4105CZN Potassium uptake protein Ava_4812 ENOG4105MYT Heat shock protein Ava_4817 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Ava_4829 ENOG4108IJ9 (ABC) transporter Ava_4831 ENOG4108HMX isocitrate dehydrogenase (NADP) Ava_4832 ENOG4105D3Q Sugar transferase Ava_4836 ENOG4105FAT Acyl-transferase Ava_4841 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Ava_4842 ENOG4105VFN O-Antigen polymerase Ava_4843 ENOG4105CGN Glycosyl transferase (Group 1 Ava_4844 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family Ava_4847 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Ava_4856 ENOG4107QI6 Cysteine desulfurase Ava_4858 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Ava_4859 ENOG4105PW4 Sugar fermentation stimulation protein homolog Ava_4861 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Ava_4866 ENOG4105C9B Cysteine desulfurase Ava_4869 ENOG4105MZG transcriptional modulator of maze toxin, mazf Ava_4876 ENOG4105EGD dinuclear metal center protein, YbgI family Ava_4886 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Ava_4887 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Ava_4889 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_4890 ENOG4105CRQ synthase (Component I) Ava_4892 ENOG4105DK0 Indole-3-glycerol phosphate synthase Ava_4896 ENOG4108UXN response regulator Ava_4897 ENOG4105EHG Permease protein Ava_4899 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Ava_4906 ENOG4105CHR reductase Ava_4907 ENOG4105WQ3 Rna-binding protein Ava_4914 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ava_4918 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Ava_4920 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Ava_4925 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Ava_4926 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Ava_4927 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Ava_4928 ENOG4105BZU Histidine kinase Ava_4929 ENOG4105E4C Lytic transglycosylase catalytic Ava_4931 ENOG4108PXI ErfK YbiS YcfS YnhG Ava_4933 ENOG4105EMN RNA polymerase sigma factor Ava_4936 ENOG4105C8T Leucyl-tRNA synthetase Ava_4937 ENOG4108Z6B deaminase Ava_4958 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) Ava_4967 ENOG4105D05 Receptor Ava_4972 ENOG4105D7V transposase Ava_4978 ENOG4105QYV Membrane Ava_4981 ENOG4105EHV domain protein Ava_4983 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Ava_4987 ENOG4108JJB ABC transporter Ava_4993 ENOG4108JQ6 ABC transporter Ava_4995 ENOG4105BZ1 (ABC) transporter Ava_4996 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Ava_4998 ENOG4107MKT Stringent starvation protein a Ava_5000 ENOG4107QZT geranylgeranyl reductase Ava_5002 ENOG4105GVF (ABC) transporter Ava_5003 ENOG4105GVF (ABC) transporter Ava_5006 ENOG4107MKT Stringent starvation protein a Ava_5010 ENOG4105CPC Aldo Keto reductase Ava_5011 ENOG4107MKT Stringent starvation protein a Ava_5012 ENOG4105GVF (ABC) transporter Ava_5016 ENOG4105FBW Monooxygenase Ava_5024 ENOG4105DUM transcriptional regulator, lysR family Ava_5026 ENOG4107TSN permease Ava_5027 ENOG410841Q phosphoesterase PA-phosphatase related protein Ava_5029 ENOG4105EPW hflc protein Ava_5032 ENOG4105CNF WD-40 repeat protein Ava_5033 ENOG4105CHJ isochorismatase hydrolase Ava_5034 ENOG4108ZFD Antibiotic biosynthesis monooxygenase Ava_5037 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Ava_5047 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Ava_5055 ENOG4105D38 putrescine abc transporter Ava_5057 ENOG4105E2K Glycosyl transferase (Group 1 Ava_5058 ENOG4105C5R Aminotransferase Ava_5060 ENOG41081FY multiple antibiotic resistance (MarC)-related Ava_5064 ENOG4105C59 p-type ATPase Ava_5067 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Ava_A0002 ENOG4108ZF3 Phosphatase Ava_A0009 ENOG4107WDG serine threonine protein kinase Ava_A0021 ENOG4105FA0 parb-like partition protein Ava_A0022 ENOG4107QJE Chromosome Partitioning Protein Ava_A0029 ENOG4105CDU Replicative dna helicase Ava_A0029 ENOG4105CDU Replicative dna helicase Ava_B0010 ENOG4105CNF WD-40 repeat protein Ava_B0012 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ava_B0014 ENOG4105EKQ RNA-directed DNA polymerase Ava_B0028 ENOG4105EWM Histidine kinase Ava_B0029 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_B0036 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ava_B0062 ENOG4105C01 Dihydroxy-acid dehydratase Ava_B0068 ENOG4107RSM transcriptional regulator Ava_B0069 ENOG4105CFI type iii restriction protein res subunit Ava_B0091 ENOG4106H3A restriction Ava_B0100 ENOG4105D7V transposase Ava_B0104 ENOG4105CHH sulfate transporter Ava_B0106 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Ava_B0112 ENOG4105D1H recombination factor protein RarA Ava_B0132 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding Ava_B0134 ENOG4108M24 von Willebrand factor, type A Ava_B0142 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ava_B0143 ENOG4105E0R Deoxyhypusine synthase Ava_B0145 ENOG4105CA0 peroxidase Ava_B0150 ENOG4105CNM Receptor Ava_B0151 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Ava_B0152 ENOG4105EHG Permease protein Ava_B0153 ENOG4105E0A ABC, transporter Ava_B0159 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Ava_B0161 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Ava_B0162 ENOG4105EHG Permease protein Ava_B0163 ENOG4105E0A ABC, transporter Ava_B0165 ENOG4105C8Y Acetylornithine aminotransferase Ava_B0166 ENOG4105E0R Deoxyhypusine synthase Ava_B0169 ENOG4105CE1 Ferrous iron transport protein b Ava_B0172 ENOG4105C4M (Ubiquinol oxidase) subunit I Ava_B0173 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Ava_B0175 ENOG4105C4M (Ubiquinol oxidase) subunit I Ava_B0185 ENOG4107ZSV Receptor Ava_B0189 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ava_B0191 ENOG4105BZU Histidine kinase Ava_B0200 ENOG4108PWY Carbohydrate-selective porin OprB Ava_B0204 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Ava_B0206 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_B0207 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Ava_B0208 ENOG4105ES5 Histidine kinase Ava_B0209 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_B0212 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) Ava_B0214 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ava_B0217 ENOG4105E0K tonB-dependent siderophore receptor Ava_B0218 ENOG4105E0K tonB-dependent siderophore receptor Ava_B0222 ENOG4105CC5 ABC transporter Ava_B0223 ENOG4105FDK ABC transporter Ava_B0224 ENOG4105DSE periplasmic solute binding protein Ava_B0225 ENOG4105D52 delta-aminolevulinic acid dehydratase Ava_B0226 ENOG4105C22 threonyL-tRNA synthetase Ava_B0228 ENOG4105CKI cobalamin synthesis protein Ava_B0229 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ava_B0237 ENOG4108JJA ABC, transporter Ava_B0239 ENOG4108PWY Carbohydrate-selective porin OprB Ava_B0243 ENOG4105C7H Helicase, RecD TraA family Ava_B0282 ENOG4105C0D helicase Ava_B0282 ENOG4105C0D helicase Ava_B0285 ENOG4105D7V transposase Ava_B0294 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family Ava_B0304 ENOG4105C3J Cysteine desulfurase Ava_B0306 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Ava_B0307 ENOG4105CFI type iii restriction protein res subunit Ava_B0328 ENOG4105CDU Replicative dna helicase Ava_C0003 ENOG4105EV8 ectoine hydroxylase Ava_C0010 ENOG4105E0K tonB-dependent siderophore receptor Ava_C0013 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ava_C0015 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) Ava_C0023 ENOG4108PWY Carbohydrate-selective porin OprB Ava_C0027 ENOG41075H3 AraC family transcriptional regulator Ava_C0030 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ava_C0033 ENOG4105EKQ RNA-directed DNA polymerase Ava_C0058 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Ava_C0060 ENOG4108I5C dEAD DEAH box helicase Ava_C0071 ENOG4105D7V transposase Ava_C0076 ENOG4105C6E dna polymerase iii Ava_C0084 ENOG4105FA2 dna polymerase iii Ava_C0090 ENOG4105K70 DNA-binding protein Ava_C0099 ENOG4107FCW Abortive infection protein Ava_C0106 ENOG4105CHJ isochorismatase hydrolase Ava_C0109 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Ava_C0111 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Ava_C0112 ENOG4105EMU Dehydrogenase Ava_C0115 ENOG4105CF7 AraC family transcriptional regulator Ava_C0116 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_C0117 ENOG4105D9P serine threonine protein kinase Ava_C0121 ENOG4107QJE Chromosome Partitioning Protein Ava_C0123 ENOG4105FA0 parb-like partition protein Ava_C0125 ENOG4105XRQ Xanthine dehydrogenase accessory factor Ava_C0126 ENOG4105C7W Xanthine dehydrogenase Ava_C0127 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding Ava_C0128 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit Ava_C0132 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Ava_C0138 ENOG4105CV8 reductase Ava_C0140 ENOG4105J0C Ava_C0142 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Ava_C0145 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Ava_C0148 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Ava_C0152 ENOG4108J5G 6-phosphogluconate dehydrogenase Ava_C0156 ENOG4105BZU Histidine kinase Ava_C0162 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ava_C0164 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Ava_C0174 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ava_C0194 ENOG4105WH1 Two component transcriptional regulator luxr family Ava_C0210 ENOG4105DR5 peptidase Ava_C0233 ENOG4105C0D helicase Ava_D0015 ENOG4105K70 DNA-binding protein Ava_D0022 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ava_D0026 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)