locus-tag	class	description
Ava_0002	COG0592	DNA-directed DNA polymerase activity
Ava_0003	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ava_0004	COG0601	transmembrane transport
Ava_0005	COG4106	trans-aconitate 2-methyltransferase activity
Ava_0013	COG2267	carboxylic ester hydrolase activity
Ava_0016	COG0371	Dehydrogenase
Ava_0017	COG0436	Aminotransferase
Ava_0018	COG0640	Transcriptional regulator
Ava_0021	COG0351	phosphomethylpyrimidine kinase
Ava_0021	COG0352	thiamine-phosphate diphosphorylase activity
Ava_0021	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Ava_0022	COG0463	Glycosyl transferase, family 2
Ava_0023	COG0129	dihydroxy-acid dehydratase activity
Ava_0026	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ava_0027	COG0724	RNA recognition motif
Ava_0030	COG1754	DNA topoisomerase type I activity
Ava_0030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ava_0032	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ava_0034	COG1480	7TM receptor with intracellular HD hydrolase
Ava_0036	COG0723	plastoquinol--plastocyanin reductase activity
Ava_0039	COG2319	Wd-40 repeat
Ava_0039	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_0044	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Ava_0045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ava_0046	COG0573	inorganic phosphate transmembrane transporter activity
Ava_0047	COG0581	inorganic phosphate transmembrane transporter activity
Ava_0055	COG3852	Histidine kinase
Ava_0056	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ava_0056	COG3409	Peptidoglycan-binding domain 1 protein
Ava_0058	COG0784	Response regulator, receiver
Ava_0061	COG0840	transmembrane signaling receptor activity
Ava_0062	COG0643	Histidine kinase
Ava_0062	COG2198	Histidine kinase
Ava_0064	COG5001	Diguanylate cyclase
Ava_0064	COG4251	negative regulation of phosphorylation
Ava_0064	COG3706	GGDEF domain
Ava_0064	COG2203	Gaf domain
Ava_0065	COG0745	RESPONSE REGULATOR receiver
Ava_0066	COG5002	protein histidine kinase activity
Ava_0068	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_0083	COG3852	Histidine kinase
Ava_0084	COG0515	serine threonine protein kinase
Ava_0090	COG0438	transferase activity, transferring glycosyl groups
Ava_0090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ava_0094	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ava_0096	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ava_0103	COG2072	flavoprotein involved in K transport
Ava_0108	COG0667	Aldo Keto reductase
Ava_0109	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ava_0112	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ava_0113	COG0546	phosphoglycolate phosphatase activity
Ava_0116	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Ava_0118	COG0802	atpase or kinase
Ava_0120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ava_0126	COG3854	ATPases associated with a variety of cellular activities
Ava_0127	COG0010	Belongs to the arginase family
Ava_0128	COG0724	RNA recognition motif
Ava_0130	COG4783	chaperone-mediated protein folding
Ava_0134	COG0667	Aldo Keto reductase
Ava_0139	COG0346	lactoylglutathione lyase activity
Ava_0140	COG0542	response to heat
Ava_0144	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_0145	COG0793	Belongs to the peptidase S41A family
Ava_0147	COG0174	glutamine synthetase
Ava_0149	COG2226	methyltransferase
Ava_0153	COG0515	serine threonine protein kinase
Ava_0153	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_0154	COG1063	alcohol dehydrogenase
Ava_0155	COG0306	phosphate transporter
Ava_0157	COG0697	spore germination
Ava_0159	COG0436	Aminotransferase
Ava_0160	COG3118	belongs to the thioredoxin family
Ava_0161	COG1842	Phage shock protein A
Ava_0162	COG1842	Phage shock protein A
Ava_0169	COG0572	uridine kinase
Ava_0176	COG0686	Belongs to the AlaDH PNT family
Ava_0177	COG3639	organic phosphonate transmembrane transporter activity
Ava_0182	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ava_0183	COG0739	heme binding
Ava_0187	COG3118	belongs to the thioredoxin family
Ava_0188	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ava_0191	COG1131	(ABC) transporter
Ava_0194	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ava_0200	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ava_0203	COG0316	Belongs to the HesB IscA family
Ava_0206	COG1090	epimerase
Ava_0207	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Ava_0219	COG3266	domain, Protein
Ava_0219	COG0515	serine threonine protein kinase
Ava_0220	COG0515	serine threonine protein kinase
Ava_0224	COG3706	GGDEF domain
Ava_0224	COG0745	RESPONSE REGULATOR receiver
Ava_0239	COG0745	RESPONSE REGULATOR receiver
Ava_0243	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ava_0248	COG1598	PFAM Uncharacterised protein family UPF0150
Ava_0252	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ava_0257	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ava_0257	COG0189	ligase activity
Ava_0259	COG1649	PFAM Uncharacterised BCR, COG1649
Ava_0261	COG3385	transposase activity
Ava_0262	COG1570	exodeoxyribonuclease VII activity
Ava_0268	COG1215	transferase activity, transferring glycosyl groups
Ava_0269	COG1215	transferase activity, transferring glycosyl groups
Ava_0277	COG0552	protein localization to endoplasmic reticulum
Ava_0278	COG2208	phosphoserine phosphatase activity
Ava_0283	COG0312	modulator of DNA gyrase
Ava_0285	COG0523	cobalamin synthesis protein
Ava_0295	COG0443	Heat shock 70 kDa protein
Ava_0296	COG0826	peptidase U32
Ava_0299	COG0793	Belongs to the peptidase S41A family
Ava_0300	COG1215	transferase activity, transferring glycosyl groups
Ava_0315	COG0671	phosphoesterase, PA-phosphatase related
Ava_0316	COG0308	aminopeptidase N
Ava_0318	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ava_0324	COG0438	transferase activity, transferring glycosyl groups
Ava_0325	COG1132	(ABC) transporter
Ava_0330	COG1372	Participates in initiation and elongation during chromosome replication
Ava_0330	COG1372	Participates in initiation and elongation during chromosome replication
Ava_0330	COG0305	Participates in initiation and elongation during chromosome replication
Ava_0330	COG0305	Participates in initiation and elongation during chromosome replication
Ava_0334	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ava_0338	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ava_0344	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Ava_0347	COG1943	Transposase
Ava_0353	COG0515	serine threonine protein kinase
Ava_0356	COG1187	pseudouridine synthase activity
Ava_0362	COG4999	Histidine kinase
Ava_0362	COG2205	protein histidine kinase activity
Ava_0362	COG3850	Histidine kinase
Ava_0362	COG3437	response regulator, receiver
Ava_0367	COG3546	catalase activity
Ava_0368	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ava_0368	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ava_0369	COG3932	Exopolysaccharide synthesis, ExoD
Ava_0371	COG4636	protein conserved in cyanobacteria
Ava_0376	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Ava_0378	COG0443	Heat shock 70 kDa protein
Ava_0382	COG1543	Belongs to the glycosyl hydrolase 57 family
Ava_0387	COG0805	protein transport
Ava_0390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ava_0404	COG0330	HflC and HflK could
Ava_0406	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ava_0409	COG0628	permease
Ava_0411	COG1316	TRANSCRIPTIONal
Ava_0413	COG3852	Histidine kinase
Ava_0415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ava_0417	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ava_0417	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Ava_0418	COG1131	(ABC) transporter
Ava_0424	COG0719	Fe-S assembly protein
Ava_0425	COG0396	ATPase activity
Ava_0426	COG0719	Fe-S assembly protein
Ava_0427	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ava_0429	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ava_0432	COG0793	Belongs to the peptidase S41A family
Ava_0434	COG0515	serine threonine protein kinase
Ava_0434	COG2815	serine threonine protein kinase
Ava_0435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ava_0437	COG1104	cysteine desulfurase activity
Ava_0441	COG0574	Belongs to the PEP-utilizing enzyme family
Ava_0441	COG3848	Pyruvate phosphate dikinase
Ava_0445	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Ava_0452	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ava_0457	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ava_0461	COG1175	transmembrane transport
Ava_0462	COG1505	serine-type exopeptidase activity
Ava_0463	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_0466	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ava_0470	COG0411	ABC transporter
Ava_0473	COG0410	ABC transporter
Ava_0476	COG2082	Precorrin-8x methylmutase
Ava_0485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ava_0496	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Ava_0505	COG0643	Histidine kinase
Ava_0505	COG0643	Histidine kinase
Ava_0505	COG2198	Histidine kinase
Ava_0505	COG2198	Histidine kinase
Ava_0506	COG0840	transmembrane signaling receptor activity
Ava_0509	COG0784	Response regulator, receiver
Ava_0511	COG0037	tRNA processing
Ava_0516	COG0439	Biotin carboxylase
Ava_0519	COG0515	serine threonine protein kinase
Ava_0521	COG2203	Gaf domain
Ava_0521	COG4251	negative regulation of phosphorylation
Ava_0521	COG3706	GGDEF domain
Ava_0521	COG5001	Diguanylate cyclase
Ava_0523	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ava_0528	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ava_0529	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ava_0530	COG1845	cytochrome c oxidase, subunit III
Ava_0538	COG2197	response regulator
Ava_0545	COG1331	Highly conserved protein containing a thioredoxin domain
Ava_0549	COG0557	exoribonuclease II activity
Ava_0550	COG0163	prenyltransferase activity
Ava_0558	COG0628	permease
Ava_0564	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Ava_0566	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ava_0568	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ava_0569	COG1049	propionate catabolic process, 2-methylcitrate cycle
Ava_0572	COG0443	Heat shock 70 kDa protein
Ava_0573	COG4294	response to UV
Ava_0575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_0581	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ava_0581	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ava_0586	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ava_0587	COG4095	Psort location CytoplasmicMembrane, score
Ava_0590	COG0271	Belongs to the BolA IbaG family
Ava_0591	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Ava_0592	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ava_0597	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ava_0599	COG0577	efflux transmembrane transporter activity
Ava_0599	COG1136	(ABC) transporter
Ava_0602	COG1309	transcriptional regulator
Ava_0610	COG0697	spore germination
Ava_0612	COG5002	protein histidine kinase activity
Ava_0613	COG5002	protein histidine kinase activity
Ava_0615	COG0745	RESPONSE REGULATOR receiver
Ava_0617	COG0668	transmembrane transport
Ava_0629	COG0233	cytoplasmic translational termination
Ava_0631	COG1228	amidohydrolase
Ava_0636	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Ava_0639	COG4243	Vitamin k epoxide reductase
Ava_0640	COG0434	BtpA family
Ava_0642	COG0513	Belongs to the DEAD box helicase family
Ava_0645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ava_0647	COG3920	Histidine kinase
Ava_0647	COG2202	Pas domain
Ava_0649	COG2205	protein histidine kinase activity
Ava_0659	COG2884	Cell division ATP-binding protein ftsE
Ava_0661	COG2197	response regulator
Ava_0667	COG2119	membrane
Ava_0668	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Ava_0671	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Ava_0673	COG0464	growth
Ava_0676	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ava_0677	COG3228	Belongs to the MtfA family
Ava_0681	COG0667	Aldo Keto reductase
Ava_0682	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ava_0684	COG3021	interspecies interaction between organisms
Ava_0685	COG0596	Alpha beta hydrolase
Ava_0709	COG0201	protein transport
Ava_0710	COG0563	adenylate kinase activity
Ava_0717	COG0101	tRNA pseudouridine synthase activity
Ava_0722	COG0488	(ABC) transporter
Ava_0727	COG0438	transferase activity, transferring glycosyl groups
Ava_0735	COG0799	negative regulation of ribosome biogenesis
Ava_0736	COG0297	glycogen (starch) synthase activity
Ava_0737	COG1126	abc transporter atp-binding protein
Ava_0738	COG0765	amino acid transport
Ava_0739	COG4597	amino acid ABC transporter
Ava_0740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_0743	COG0602	queuosine metabolic process
Ava_0744	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_0748	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ava_0749	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ava_0750	COG4279	zinc finger
Ava_0751	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_0754	COG0024	Methionine aminopeptidase
Ava_0755	COG0673	inositol 2-dehydrogenase activity
Ava_0757	COG2385	sporulation resulting in formation of a cellular spore
Ava_0759	COG0783	Belongs to the Dps family
Ava_0771	COG0589	response to stress
Ava_0773	COG1051	belongs to the nudix hydrolase family
Ava_0781	COG0572	uridine kinase
Ava_0783	COG0460	homoserine dehydrogenase
Ava_0784	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ava_0787	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
Ava_0791	COG0745	RESPONSE REGULATOR receiver
Ava_0792	COG5002	protein histidine kinase activity
Ava_0794	COG0751	glycine-tRNA ligase activity
Ava_0795	COG0598	Magnesium transport protein CorA
Ava_0797	COG0571	ribonuclease III activity
Ava_0798	COG0673	inositol 2-dehydrogenase activity
Ava_0799	COG5002	protein histidine kinase activity
Ava_0799	COG2205	protein histidine kinase activity
Ava_0799	COG0784	Response regulator, receiver
Ava_0807	COG0583	DNA-binding transcription factor activity
Ava_0810	COG1252	NADH dehydrogenase
Ava_0814	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_0816	COG0606	chelatase, subunit chli
Ava_0817	COG0537	adenosine 5'-monophosphoramidase activity
Ava_0823	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ava_0824	COG0583	DNA-binding transcription factor activity
Ava_0825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ava_0825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Ava_0826	COG0456	acetyltransferase
Ava_0828	COG4251	negative regulation of phosphorylation
Ava_0828	COG3706	GGDEF domain
Ava_0828	COG5001	Diguanylate cyclase
Ava_0828	COG2203	Gaf domain
Ava_0830	COG0242	peptide deformylase activity
Ava_0831	COG5634	Uncharacterized conserved protein (DUF2278)
Ava_0838	COG1216	Glycosyl transferase, family 2
Ava_0838	COG0463	Glycosyl transferase, family 2
Ava_0839	COG2244	polysaccharide biosynthetic process
Ava_0840	COG1215	transferase activity, transferring glycosyl groups
Ava_0841	COG1215	transferase activity, transferring glycosyl groups
Ava_0842	COG0438	transferase activity, transferring glycosyl groups
Ava_0845	COG5039	Polysaccharide pyruvyl transferase
Ava_0846	COG2244	polysaccharide biosynthetic process
Ava_0847	COG0438	transferase activity, transferring glycosyl groups
Ava_0848	COG0463	Glycosyl transferase, family 2
Ava_0848	COG1216	Glycosyl transferase, family 2
Ava_0849	COG0463	Glycosyl transferase, family 2
Ava_0849	COG1216	Glycosyl transferase, family 2
Ava_0850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Ava_0853	COG0438	transferase activity, transferring glycosyl groups
Ava_0854	COG0438	transferase activity, transferring glycosyl groups
Ava_0861	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ava_0867	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ava_0868	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ava_0869	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ava_0871	COG1233	COG1233 Phytoene dehydrogenase and related
Ava_0873	COG2205	protein histidine kinase activity
Ava_0873	COG3850	Histidine kinase
Ava_0873	COG4999	Histidine kinase
Ava_0873	COG3437	response regulator, receiver
Ava_0874	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ava_0875	COG1116	anion transmembrane transporter activity
Ava_0875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_0876	COG1116	anion transmembrane transporter activity
Ava_0878	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Ava_0881	COG0481	GTPase activity
Ava_0883	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Ava_0890	COG0668	transmembrane transport
Ava_0893	COG1573	uracil-dna glycosylase
Ava_0900	COG0390	transport system, permease component
Ava_0910	COG0542	response to heat
Ava_0911	COG0456	acetyltransferase
Ava_0912	COG0019	diaminopimelate decarboxylase activity
Ava_0913	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Ava_0916	COG0484	heat shock protein binding
Ava_0918	COG0484	heat shock protein binding
Ava_0920	COG2234	aminopeptidase activity
Ava_0922	COG3781	membrane
Ava_0931	COG0681	Belongs to the peptidase S26 family
Ava_0936	COG1053	succinate dehydrogenase
Ava_0938	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ava_0943	COG0300	oxidoreductase activity
Ava_0947	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ava_0947	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ava_0949	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ava_0950	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ava_0951	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ava_0956	COG0628	permease
Ava_0957	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ava_0957	COG0284	orotidine-5'-phosphate decarboxylase activity
Ava_0958	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Ava_0961	COG0613	PHP domain protein
Ava_0963	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ava_0965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Ava_0967	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Ava_0973	COG3338	carbonate dehydratase activity
Ava_0974	COG0724	RNA recognition motif
Ava_0976	COG1040	competence protein
Ava_0980	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_0981	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ava_0983	COG0483	inositol monophosphate 1-phosphatase activity
Ava_0984	COG0484	heat shock protein binding
Ava_0986	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ava_0989	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_0990	COG0288	reversible hydration of carbon dioxide
Ava_0992	COG2217	Heavy metal translocating P-type atpase
Ava_1002	COG1230	cation diffusion facilitator family transporter
Ava_1003	COG4251	negative regulation of phosphorylation
Ava_1004	COG0784	Response regulator, receiver
Ava_1005	COG2202	Pas domain
Ava_1005	COG2205	protein histidine kinase activity
Ava_1011	COG0300	oxidoreductase activity
Ava_1016	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Ava_1021	COG2205	protein histidine kinase activity
Ava_1024	COG1116	anion transmembrane transporter activity
Ava_1025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_1025	COG1116	anion transmembrane transporter activity
Ava_1026	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ava_1027	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_1030	COG2203	Gaf domain
Ava_1030	COG5001	Diguanylate cyclase
Ava_1030	COG4251	negative regulation of phosphorylation
Ava_1030	COG3706	GGDEF domain
Ava_1034	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ava_1038	COG1215	transferase activity, transferring glycosyl groups
Ava_1041	COG0438	transferase activity, transferring glycosyl groups
Ava_1045	COG0489	protein tyrosine kinase activity
Ava_1046	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_1048	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Ava_1057	COG0730	response to heat
Ava_1059	COG1473	amidohydrolase
Ava_1061	COG1032	radical SAM domain protein
Ava_1063	COG1733	regulation of RNA biosynthetic process
Ava_1067	COG0569	domain protein
Ava_1069	COG0025	NhaP-type Na H and K H
Ava_1075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ava_1078	COG2226	methyltransferase
Ava_1080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ava_1080	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ava_1080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ava_1080	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ava_1087	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Ava_1089	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Ava_1090	COG3977	Valine--pyruvate aminotransferase
Ava_1103	COG4245	von Willebrand factor, type A
Ava_1106	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ava_1107	COG0579	oxidoreductase
Ava_1108	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Ava_1114	COG0460	homoserine dehydrogenase
Ava_1116	COG0489	protein tyrosine kinase activity
Ava_1118	COG1132	(ABC) transporter
Ava_1119	COG1215	transferase activity, transferring glycosyl groups
Ava_1122	COG0438	transferase activity, transferring glycosyl groups
Ava_1126	COG0640	Transcriptional regulator
Ava_1138	COG2207	Transcriptional regulator
Ava_1138	COG0662	Cupin 2, conserved barrel domain protein
Ava_1149	COG5002	protein histidine kinase activity
Ava_1153	COG0515	serine threonine protein kinase
Ava_1153	COG2815	serine threonine protein kinase
Ava_1156	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ava_1162	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ava_1164	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_1165	COG0735	belongs to the Fur family
Ava_1168	COG2205	protein histidine kinase activity
Ava_1168	COG2202	Pas domain
Ava_1172	COG2239	Acts as a magnesium transporter
Ava_1175	COG2205	protein histidine kinase activity
Ava_1177	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ava_1180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ava_1186	COG0297	glycogen (starch) synthase activity
Ava_1188	COG2274	protein secretion by the type I secretion system
Ava_1189	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ava_1191	COG2205	protein histidine kinase activity
Ava_1192	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Ava_1194	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Ava_1195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Ava_1196	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ava_1197	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ava_1198	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_1201	COG0673	inositol 2-dehydrogenase activity
Ava_1204	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ava_1206	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ava_1213	COG1285	pathogenesis
Ava_1214	COG0431	NADPH-dependent FMN reductase
Ava_1218	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_1225	COG1695	Transcriptional regulator
Ava_1226	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ava_1234	COG1136	(ABC) transporter
Ava_1234	COG0577	efflux transmembrane transporter activity
Ava_1236	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Ava_1237	COG2211	Major facilitator Superfamily
Ava_1238	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ava_1239	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ava_1240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ava_1246	COG3409	Peptidoglycan-binding domain 1 protein
Ava_1246	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ava_1248	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_1255	COG3437	response regulator, receiver
Ava_1255	COG2770	Histidine kinase
Ava_1263	COG0745	RESPONSE REGULATOR receiver
Ava_1275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ava_1280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ava_1281	COG1530	ribonuclease E activity
Ava_1285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ava_1291	COG0316	Belongs to the HesB IscA family
Ava_1292	COG0662	Cupin 2, conserved barrel domain protein
Ava_1292	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Ava_1294	COG0069	glutamate synthase activity
Ava_1294	COG0067	glutamate synthase
Ava_1294	COG0070	glutamate synthase
Ava_1295	COG0726	polysaccharide deacetylase
Ava_1297	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ava_1306	COG0740	serine-type endopeptidase activity
Ava_1307	COG2304	oxidoreductase activity
Ava_1308	COG2304	oxidoreductase activity
Ava_1309	COG0346	lactoylglutathione lyase activity
Ava_1312	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ava_1316	COG0443	Heat shock 70 kDa protein
Ava_1322	COG0557	exoribonuclease II activity
Ava_1336	COG3655	Transcriptional regulator
Ava_1350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Ava_1351	COG0484	heat shock protein binding
Ava_1356	COG3903	Transcriptional regulator
Ava_1356	COG2319	Wd-40 repeat
Ava_1358	COG0450	alkyl hydroperoxide reductase
Ava_1359	COG2304	oxidoreductase activity
Ava_1362	COG0438	transferase activity, transferring glycosyl groups
Ava_1365	COG0438	transferase activity, transferring glycosyl groups
Ava_1369	COG0426	domain, Protein
Ava_1369	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1371	COG0426	domain, Protein
Ava_1371	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1374	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_1375	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ava_1379	COG0438	transferase activity, transferring glycosyl groups
Ava_1385	COG1216	Glycosyl transferase, family 2
Ava_1386	COG0489	protein tyrosine kinase activity
Ava_1386	COG3206	protein involved in exopolysaccharide biosynthesis
Ava_1397	COG2268	Band 7 protein
Ava_1400	COG2223	nitrite transmembrane transporter activity
Ava_1403	COG0456	acetyltransferase
Ava_1405	COG0662	Cupin 2, conserved barrel domain protein
Ava_1405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Ava_1409	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_1410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_1411	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ava_1417	COG4942	peptidase
Ava_1418	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Ava_1418	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Ava_1420	COG0385	Bile acid
Ava_1423	COG2204	response regulator
Ava_1425	COG1074	ATP-dependent DNA helicase activity
Ava_1433	COG1136	(ABC) transporter
Ava_1434	COG0501	Belongs to the peptidase M48B family
Ava_1436	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ava_1438	COG0426	domain, Protein
Ava_1438	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1439	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1439	COG0426	domain, Protein
Ava_1442	COG4636	protein conserved in cyanobacteria
Ava_1447	COG0745	RESPONSE REGULATOR receiver
Ava_1452	COG1131	(ABC) transporter
Ava_1457	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ava_1457	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ava_1461	COG1077	Cell shape determining protein MreB Mrl
Ava_1462	COG0629	single-stranded DNA binding
Ava_1464	COG0475	glutathione-regulated potassium exporter activity
Ava_1465	COG2247	cell wall binding repeat
Ava_1465	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ava_1469	COG0142	geranyltranstransferase activity
Ava_1473	COG1305	Transglutaminase-like
Ava_1474	COG2052	Domain of unknown function (DUF370)
Ava_1482	COG0454	-acetyltransferase
Ava_1484	COG2890	protein-(glutamine-N5) methyltransferase activity
Ava_1487	COG0454	-acetyltransferase
Ava_1489	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ava_1490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ava_1491	COG0022	dehydrogenase e1 component
Ava_1491	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ava_1495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ava_1497	COG0644	oxidoreductase
Ava_1498	COG0745	RESPONSE REGULATOR receiver
Ava_1499	COG0429	hydrolase of the alpha beta-hydrolase fold
Ava_1505	COG0539	negative regulation of cytoplasmic translation
Ava_1509	COG0747	negative chemotaxis
Ava_1511	COG0328	RNA-DNA hybrid ribonuclease activity
Ava_1519	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ava_1520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Ava_1521	COG0772	Belongs to the SEDS family
Ava_1527	COG0438	transferase activity, transferring glycosyl groups
Ava_1529	COG2010	Cytochrome c
Ava_1532	COG1950	PFAM Membrane protein of
Ava_1534	COG2183	response to ionizing radiation
Ava_1536	COG1192	Involved in chromosome partitioning
Ava_1544	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ava_1548	COG2217	Heavy metal translocating P-type atpase
Ava_1552	COG0515	serine threonine protein kinase
Ava_1552	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_1556	COG2319	Wd-40 repeat
Ava_1556	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_1558	COG2197	response regulator
Ava_1559	COG5001	Diguanylate cyclase
Ava_1560	COG0784	Response regulator, receiver
Ava_1560	COG2198	Histidine kinase
Ava_1560	COG5002	protein histidine kinase activity
Ava_1561	COG5002	protein histidine kinase activity
Ava_1561	COG0784	Response regulator, receiver
Ava_1562	COG3706	GGDEF domain
Ava_1562	COG0745	RESPONSE REGULATOR receiver
Ava_1564	COG0784	Response regulator, receiver
Ava_1564	COG2205	protein histidine kinase activity
Ava_1564	COG5002	protein histidine kinase activity
Ava_1566	COG0745	RESPONSE REGULATOR receiver
Ava_1572	COG0300	oxidoreductase activity
Ava_1575	COG2226	methyltransferase
Ava_1577	COG0402	S-adenosylhomocysteine deaminase activity
Ava_1588	COG4636	protein conserved in cyanobacteria
Ava_1590	COG1830	Aldolase
Ava_1592	COG0515	serine threonine protein kinase
Ava_1592	COG3266	domain, Protein
Ava_1593	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ava_1594	COG2226	methyltransferase
Ava_1599	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ava_1600	COG1121	(ABC) transporter
Ava_1603	COG0587	DNA-directed DNA polymerase activity
Ava_1609	COG0300	oxidoreductase activity
Ava_1609	COG3321	synthase
Ava_1609	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Ava_1609	COG0318	PFAM AMP-dependent synthetase and ligase
Ava_1609	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_1616	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ava_1617	COG4178	(ABC) transporter
Ava_1622	COG4178	(ABC) transporter
Ava_1624	COG2319	Wd-40 repeat
Ava_1624	COG1672	PFAM Archaeal ATPase
Ava_1627	COG3437	response regulator, receiver
Ava_1628	COG2202	Pas domain
Ava_1628	COG2205	protein histidine kinase activity
Ava_1631	COG0668	transmembrane transport
Ava_1632	COG0475	glutathione-regulated potassium exporter activity
Ava_1641	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
Ava_1643	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ava_1646	COG1696	Membrane protein involved in D-alanine export
Ava_1647	COG0300	oxidoreductase activity
Ava_1647	COG4221	oxidoreductase activity
Ava_1647	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_1647	COG3321	synthase
Ava_1648	COG1960	acyl-CoA dehydrogenase activity
Ava_1649	COG0318	PFAM AMP-dependent synthetase and ligase
Ava_1651	COG0354	folic acid binding
Ava_1653	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ava_1655	COG3959	Transketolase, thiamine diphosphate binding domain
Ava_1659	COG0435	Glutathione S-transferase
Ava_1668	COG1045	serine acetyltransferase
Ava_1669	COG0259	pyridoxamine-phosphate oxidase activity
Ava_1672	COG4771	TonB-dependent receptor
Ava_1674	COG1271	oxidase subunit
Ava_1679	COG0724	RNA recognition motif
Ava_1681	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Ava_1682	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Ava_1683	COG3409	Peptidoglycan-binding domain 1 protein
Ava_1683	COG3429	Glucose-6-phosphate dehydrogenase subunit
Ava_1687	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Ava_1689	COG0616	signal peptide processing
Ava_1691	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
Ava_1694	COG0469	pyruvate kinase activity
Ava_1700	COG0515	serine threonine protein kinase
Ava_1700	COG3266	domain, Protein
Ava_1702	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ava_1707	COG3609	addiction module antidote protein, CC2985 family
Ava_1709	COG0419	ATPase involved in DNA repair
Ava_1716	COG2205	protein histidine kinase activity
Ava_1716	COG0784	Response regulator, receiver
Ava_1719	COG5002	protein histidine kinase activity
Ava_1730	COG0750	zinc metalloprotease
Ava_1731	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Ava_1737	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ava_1746	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ava_1747	COG3118	belongs to the thioredoxin family
Ava_1750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_1751	COG0018	arginyl-trna synthetase
Ava_1752	COG0561	phosphatase activity
Ava_1753	COG1122	ATPase activity
Ava_1755	COG0310	cobalt ion transport
Ava_1756	COG1122	ATPase activity
Ava_1758	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Ava_1759	COG0310	cobalt ion transport
Ava_1760	COG2132	Multicopper oxidase
Ava_1763	COG0672	)-iron permease
Ava_1764	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ava_1766	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ava_1767	COG0776	regulation of translation
Ava_1768	COG1797	cobyrinic acid a,c-diamide synthase activity
Ava_1775	COG1446	asparaginase
Ava_1777	COG3437	response regulator, receiver
Ava_1778	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ava_1778	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Ava_1783	COG0045	succinate-CoA ligase (ADP-forming) activity
Ava_1786	COG1770	oligopeptidase
Ava_1789	COG3320	Male sterility
Ava_1789	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_1792	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ava_1793	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ava_1795	COG1032	radical SAM domain protein
Ava_1797	COG0517	IMP dehydrogenase activity
Ava_1797	COG1994	Peptidase M50
Ava_1800	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_1802	COG0426	domain, Protein
Ava_1802	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1803	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ava_1803	COG0426	domain, Protein
Ava_1809	COG1691	(AIR) carboxylase
Ava_1810	COG0747	negative chemotaxis
Ava_1815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ava_1816	COG0515	serine threonine protein kinase
Ava_1816	COG3266	domain, Protein
Ava_1818	COG0575	Belongs to the CDS family
Ava_1820	COG1187	pseudouridine synthase activity
Ava_1821	COG1426	Protein conserved in bacteria
Ava_1822	COG1640	4-alpha-glucanotransferase
Ava_1824	COG0251	oxidation-reduction process
Ava_1826	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ava_1835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ava_1836	COG0189	ligase activity
Ava_1837	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ava_1841	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_1841	COG2319	Wd-40 repeat
Ava_1844	COG1191	sigma factor activity
Ava_1870	COG0195	Participates in both transcription termination and antitermination
Ava_1877	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Ava_1889	COG0517	IMP dehydrogenase activity
Ava_1889	COG0516	GMP reductase activity
Ava_1890	COG0494	nUDIX hydrolase
Ava_1892	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_1893	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ava_1894	COG0783	Belongs to the Dps family
Ava_1896	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Ava_1901	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_1904	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_1905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_1908	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_1909	COG0401	homolog of Blt101
Ava_1910	COG0023	Translation Initiation Factor
Ava_1914	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Ava_1917	COG0745	RESPONSE REGULATOR receiver
Ava_1918	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ava_1922	COG0745	RESPONSE REGULATOR receiver
Ava_1927	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ava_1931	COG3659	wide pore channel activity
Ava_1940	COG1429	ligase activity, forming nitrogen-metal bonds
Ava_1941	COG1132	(ABC) transporter
Ava_1942	COG1132	(ABC) transporter
Ava_1944	COG0745	RESPONSE REGULATOR receiver
Ava_1945	COG5002	protein histidine kinase activity
Ava_1945	COG5000	phosphorelay sensor kinase activity
Ava_1946	COG0113	porphobilinogen synthase activity
Ava_1947	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ava_1948	COG0523	cobalamin synthesis protein
Ava_1949	COG0302	gtp cyclohydrolase
Ava_1951	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_1952	COG0513	Belongs to the DEAD box helicase family
Ava_1955	COG1132	(ABC) transporter
Ava_1957	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Ava_1960	COG2234	aminopeptidase activity
Ava_1966	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ava_1975	COG1846	Transcriptional regulator
Ava_1977	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ava_1981	COG2124	cytochrome p450
Ava_1982	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_1984	COG0724	RNA recognition motif
Ava_1985	COG1218	3'(2'),5'-bisphosphate nucleotidase
Ava_1987	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ava_1994	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ava_1995	COG3266	domain, Protein
Ava_1995	COG0515	serine threonine protein kinase
Ava_1998	COG0857	belongs to the CobB CobQ family
Ava_2002	COG0625	glutathione transferase activity
Ava_2006	COG1070	Carbohydrate kinase
Ava_2007	COG2971	BadF BadG BcrA BcrD
Ava_2010	COG3237	CsbD-like
Ava_2016	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_2018	COG1404	Belongs to the peptidase S8 family
Ava_2022	COG0484	heat shock protein binding
Ava_2024	COG0450	alkyl hydroperoxide reductase
Ava_2027	COG4585	Histidine kinase
Ava_2028	COG2197	response regulator
Ava_2030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_2035	COG0440	acetolactate synthase activity
Ava_2045	COG4172	Belongs to the ABC transporter superfamily
Ava_2046	COG0629	single-stranded DNA binding
Ava_2047	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Ava_2050	COG3842	ATPase activity
Ava_2052	COG3631	Ketosteroid isomerase-related protein
Ava_2055	COG0412	Dienelactone hydrolase
Ava_2058	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ava_2064	COG1216	Glycosyl transferase, family 2
Ava_2069	COG0586	Pfam SNARE associated Golgi protein
Ava_2073	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ava_2077	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ava_2079	COG4636	protein conserved in cyanobacteria
Ava_2084	COG3266	domain, Protein
Ava_2084	COG0515	serine threonine protein kinase
Ava_2088	COG4115	mRNA cleavage
Ava_2090	COG0038	chloride channel
Ava_2093	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_2094	COG0395	ABC-type sugar transport system, permease component
Ava_2095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Ava_2096	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_2097	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Ava_2099	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_2100	COG0438	transferase activity, transferring glycosyl groups
Ava_2103	COG2124	cytochrome p450
Ava_2104	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_2104	COG2319	Wd-40 repeat
Ava_2109	COG0515	serine threonine protein kinase
Ava_2109	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_2112	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ava_2113	COG0514	ATP-dependent DNA helicase (RecQ)
Ava_2114	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ava_2117	COG1234	tRNA 3'-trailer cleavage
Ava_2118	COG0196	riboflavin kinase activity
Ava_2119	COG0714	Associated with various cellular activities
Ava_2125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ava_2127	COG0436	Aminotransferase
Ava_2130	COG4680	protein conserved in bacteria
Ava_2131	COG0463	Glycosyl transferase, family 2
Ava_2131	COG0457	Tetratricopeptide repeat
Ava_2137	COG1696	Membrane protein involved in D-alanine export
Ava_2142	COG0590	tRNA wobble adenosine to inosine editing
Ava_2143	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ava_2144	COG0702	epimerase
Ava_2150	COG0745	RESPONSE REGULATOR receiver
Ava_2150	COG3706	GGDEF domain
Ava_2152	COG4191	Histidine kinase
Ava_2157	COG1982	Orn Lys Arg decarboxylase major
Ava_2165	COG0288	reversible hydration of carbon dioxide
Ava_2167	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_2169	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ava_2170	COG1609	Transcriptional regulator
Ava_2171	COG1879	ABC-type sugar transport system periplasmic component
Ava_2173	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ava_2174	COG3659	wide pore channel activity
Ava_2176	COG3852	Histidine kinase
Ava_2177	COG0406	alpha-ribazole phosphatase activity
Ava_2183	COG5635	Nacht domain
Ava_2183	COG2319	Wd-40 repeat
Ava_2184	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_2184	COG2319	Wd-40 repeat
Ava_2189	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ava_2198	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ava_2202	COG4636	protein conserved in cyanobacteria
Ava_2210	COG0419	ATPase involved in DNA repair
Ava_2215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ava_2218	COG1473	amidohydrolase
Ava_2222	COG4956	integral membrane protein (PIN domain superfamily)
Ava_2223	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ava_2226	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ava_2228	COG0546	phosphoglycolate phosphatase activity
Ava_2229	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ava_2230	COG3631	Ketosteroid isomerase-related protein
Ava_2233	COG0628	permease
Ava_2235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ava_2236	COG0497	DNA recombination
Ava_2243	COG3150	esterase
Ava_2244	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ava_2248	COG1695	Transcriptional regulator
Ava_2251	COG0577	efflux transmembrane transporter activity
Ava_2251	COG1136	(ABC) transporter
Ava_2252	COG3540	Alkaline phosphatase
Ava_2253	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ava_2254	COG2909	trisaccharide binding
Ava_2263	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ava_2265	COG1940	carbohydrate kinase activity
Ava_2268	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ava_2273	COG1834	amidinotransferase
Ava_2278	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ava_2282	COG0583	DNA-binding transcription factor activity
Ava_2283	COG0438	transferase activity, transferring glycosyl groups
Ava_2287	COG0748	coenzyme F420 binding
Ava_2289	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Ava_2293	COG0714	Associated with various cellular activities
Ava_2301	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ava_2302	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ava_2304	COG0768	penicillin binding
Ava_2305	COG0848	biopolymer transport protein
Ava_2306	COG0811	peptide transport
Ava_2313	COG0640	Transcriptional regulator
Ava_2314	COG0511	ligase activity, forming carbon-carbon bonds
Ava_2316	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ava_2317	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Ava_2323	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ava_2324	COG0745	RESPONSE REGULATOR receiver
Ava_2335	COG0542	response to heat
Ava_2341	COG0612	Peptidase, M16
Ava_2346	COG0463	Glycosyl transferase, family 2
Ava_2347	COG1063	alcohol dehydrogenase
Ava_2348	COG2831	hemolysin activation secretion protein
Ava_2352	COG3210	domain, Protein
Ava_2356	COG4953	penicillin-binding protein 1C
Ava_2357	COG2373	Large extracellular alpha-helical protein
Ava_2358	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ava_2361	COG1253	flavin adenine dinucleotide binding
Ava_2363	COG0673	inositol 2-dehydrogenase activity
Ava_2364	COG0586	Pfam SNARE associated Golgi protein
Ava_2367	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ava_2368	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ava_2372	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Ava_2372	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ava_2378	COG2119	membrane
Ava_2380	COG0303	'Molybdopterin
Ava_2388	COG0463	Glycosyl transferase, family 2
Ava_2391	COG2226	methyltransferase
Ava_2398	COG2274	protein secretion by the type I secretion system
Ava_2401	COG2204	response regulator
Ava_2403	COG1234	tRNA 3'-trailer cleavage
Ava_2411	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_2419	COG0745	RESPONSE REGULATOR receiver
Ava_2420	COG5002	protein histidine kinase activity
Ava_2424	COG0725	ABC transporter, periplasmic molybdate-binding protein
Ava_2428	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_2430	COG2239	Acts as a magnesium transporter
Ava_2434	COG0438	transferase activity, transferring glycosyl groups
Ava_2435	COG1132	(ABC) transporter
Ava_2437	COG3659	wide pore channel activity
Ava_2439	COG5002	protein histidine kinase activity
Ava_2440	COG0745	RESPONSE REGULATOR receiver
Ava_2443	COG0431	NADPH-dependent FMN reductase
Ava_2444	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_2446	COG2066	Belongs to the glutaminase family
Ava_2448	COG0800	Aldolase
Ava_2462	COG0616	signal peptide processing
Ava_2465	COG0811	peptide transport
Ava_2467	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ava_2469	COG0601	transmembrane transport
Ava_2478	COG0573	inorganic phosphate transmembrane transporter activity
Ava_2479	COG0581	inorganic phosphate transmembrane transporter activity
Ava_2485	COG1942	4-Oxalocrotonate Tautomerase
Ava_2488	COG1309	transcriptional regulator
Ava_2489	COG1979	alcohol dehydrogenase
Ava_2491	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_2492	COG0191	fructose-bisphosphate aldolase activity
Ava_2498	COG2442	InterPro IPR007367
Ava_2502	COG2081	HI0933 family
Ava_2507	COG0484	heat shock protein binding
Ava_2508	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ava_2509	COG1959	2 iron, 2 sulfur cluster binding
Ava_2510	COG3659	wide pore channel activity
Ava_2514	COG1122	ATPase activity
Ava_2515	COG3688	RNA-binding protein containing a PIN domain
Ava_2517	COG1372	Participates in initiation and elongation during chromosome replication
Ava_2517	COG0187	DNA topoisomerase II activity
Ava_2519	COG3266	domain, Protein
Ava_2519	COG0515	serine threonine protein kinase
Ava_2520	COG0277	FAD linked oxidase domain protein
Ava_2524	COG2203	Gaf domain
Ava_2524	COG3706	GGDEF domain
Ava_2524	COG4251	negative regulation of phosphorylation
Ava_2524	COG5001	Diguanylate cyclase
Ava_2527	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Ava_2528	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_2528	COG0515	serine threonine protein kinase
Ava_2532	COG0395	ABC-type sugar transport system, permease component
Ava_2533	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Ava_2534	COG5322	oxidoreductase activity
Ava_2536	COG0300	oxidoreductase activity
Ava_2537	COG0302	gtp cyclohydrolase
Ava_2545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ava_2548	COG1309	transcriptional regulator
Ava_2550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ava_2551	COG0250	Participates in transcription elongation, termination and antitermination
Ava_2557	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ava_2561	COG0438	transferase activity, transferring glycosyl groups
Ava_2578	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Ava_2588	COG1475	DNA binding
Ava_2590	COG3321	synthase
Ava_2590	COG0604	alcohol dehydrogenase
Ava_2591	COG4221	oxidoreductase activity
Ava_2591	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_2591	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Ava_2591	COG3321	synthase
Ava_2593	COG4221	oxidoreductase activity
Ava_2593	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_2593	COG3321	synthase
Ava_2593	COG0300	oxidoreductase activity
Ava_2594	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ava_2594	COG2070	2-Nitropropane dioxygenase
Ava_2595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_2595	COG3320	Male sterility
Ava_2596	COG0300	oxidoreductase activity
Ava_2597	COG2091	lysine biosynthetic process via aminoadipic acid
Ava_2605	COG2226	methyltransferase
Ava_2618	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ava_2620	COG0237	dephospho-CoA kinase activity
Ava_2620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ava_2624	COG2912	Transglutaminase-like superfamily
Ava_2629	COG2319	Wd-40 repeat
Ava_2629	COG3903	Transcriptional regulator
Ava_2632	COG1169	isochorismate synthase
Ava_2633	COG1575	Belongs to the MenA family. Type 1 subfamily
Ava_2635	COG4948	Mandelate Racemase Muconate Lactonizing
Ava_2637	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ava_2651	COG1193	negative regulation of DNA recombination
Ava_2653	COG0516	GMP reductase activity
Ava_2654	COG3118	belongs to the thioredoxin family
Ava_2660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ava_2661	COG0489	protein tyrosine kinase activity
Ava_2668	COG0717	Belongs to the dCTP deaminase family
Ava_2670	COG0563	adenylate kinase activity
Ava_2673	COG1127	ABC transporter
Ava_2677	COG0728	peptidoglycan biosynthetic process
Ava_2679	COG1316	TRANSCRIPTIONal
Ava_2681	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ava_2682	COG1131	(ABC) transporter
Ava_2684	COG2815	serine threonine protein kinase
Ava_2684	COG0515	serine threonine protein kinase
Ava_2692	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Ava_2693	COG0009	L-threonylcarbamoyladenylate synthase
Ava_2696	COG0514	ATP-dependent DNA helicase (RecQ)
Ava_2700	COG0628	permease
Ava_2701	COG1051	belongs to the nudix hydrolase family
Ava_2705	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Ava_2710	COG5001	Diguanylate cyclase
Ava_2712	COG2062	phosphohistidine phosphatase, SixA
Ava_2713	COG0372	Belongs to the citrate synthase family
Ava_2716	COG0839	Belongs to the complex I subunit 6 family
Ava_2717	COG0713	ATP synthesis coupled electron transport
Ava_2723	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ava_2730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ava_2731	COG0204	Acyl-transferase
Ava_2731	COG0318	PFAM AMP-dependent synthetase and ligase
Ava_2732	COG0628	permease
Ava_2736	COG0484	heat shock protein binding
Ava_2738	COG1408	metallophosphoesterase
Ava_2739	COG1408	metallophosphoesterase
Ava_2740	COG0025	NhaP-type Na H and K H
Ava_2748	COG0395	ABC-type sugar transport system, permease component
Ava_2751	COG0784	Response regulator, receiver
Ava_2752	COG0398	Pfam SNARE associated Golgi protein
Ava_2760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ava_2763	COG0312	modulator of DNA gyrase
Ava_2764	COG0312	modulator of DNA gyrase
Ava_2766	COG1253	flavin adenine dinucleotide binding
Ava_2767	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ava_2771	COG0784	Response regulator, receiver
Ava_2771	COG2205	protein histidine kinase activity
Ava_2775	COG0398	Pfam SNARE associated Golgi protein
Ava_2777	COG0006	proline dipeptidase activity
Ava_2780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ava_2780	COG0512	Glutamine amidotransferase of anthranilate synthase
Ava_2781	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Ava_2784	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Ava_2787	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ava_2788	COG3903	Transcriptional regulator
Ava_2788	COG2319	Wd-40 repeat
Ava_2790	COG1301	dicarboxylic acid transport
Ava_2798	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_2801	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_2803	COG0515	serine threonine protein kinase
Ava_2803	COG2815	serine threonine protein kinase
Ava_2805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ava_2805	COG0784	Response regulator, receiver
Ava_2809	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_2809	COG0515	serine threonine protein kinase
Ava_2813	COG1846	Transcriptional regulator
Ava_2817	COG2319	Wd-40 repeat
Ava_2817	COG3903	Transcriptional regulator
Ava_2821	COG0561	phosphatase activity
Ava_2823	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Ava_2830	COG1120	ATPase activity
Ava_2838	COG0076	glutamate decarboxylase activity
Ava_2843	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ava_2845	COG0515	serine threonine protein kinase
Ava_2845	COG2815	serine threonine protein kinase
Ava_2851	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_2851	COG0515	serine threonine protein kinase
Ava_2852	COG1136	(ABC) transporter
Ava_2854	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ava_2859	COG1136	(ABC) transporter
Ava_2859	COG0577	efflux transmembrane transporter activity
Ava_2860	COG1136	(ABC) transporter
Ava_2861	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ava_2862	COG0577	efflux transmembrane transporter activity
Ava_2862	COG1136	(ABC) transporter
Ava_2869	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_2870	COG2133	pyrroloquinoline quinone binding
Ava_2874	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ava_2874	COG1017	nitric oxide dioxygenase activity
Ava_2888	COG4221	oxidoreductase activity
Ava_2897	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Ava_2899	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ava_2901	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ava_2902	COG4581	dead DEAH box helicase
Ava_2904	COG0463	Glycosyl transferase, family 2
Ava_2904	COG1216	Glycosyl transferase, family 2
Ava_2908	COG3206	protein involved in exopolysaccharide biosynthesis
Ava_2908	COG0489	protein tyrosine kinase activity
Ava_2914	COG3956	TIGRFAM MazG family protein
Ava_2916	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ava_2917	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Ava_2922	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ava_2923	COG0784	Response regulator, receiver
Ava_2924	COG0564	pseudouridine synthase activity
Ava_2927	COG0237	dephospho-CoA kinase activity
Ava_2928	COG1413	lyase activity
Ava_2929	COG1413	lyase activity
Ava_2932	COG0237	dephospho-CoA kinase activity
Ava_2933	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Ava_2934	COG1413	lyase activity
Ava_2935	COG1413	lyase activity
Ava_2936	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ava_2937	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ava_2939	COG0237	dephospho-CoA kinase activity
Ava_2940	COG2226	methyltransferase
Ava_2942	COG1012	belongs to the aldehyde dehydrogenase family
Ava_2944	COG2205	protein histidine kinase activity
Ava_2945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ava_2952	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Ava_2953	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Ava_2954	COG0004	ammonium transporteR
Ava_2955	COG0004	ammonium transporteR
Ava_2956	COG0004	ammonium transporteR
Ava_2961	COG1125	glycine betaine transport
Ava_2961	COG0517	IMP dehydrogenase activity
Ava_2963	COG1131	(ABC) transporter
Ava_2965	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_2971	COG2319	Wd-40 repeat
Ava_2971	COG1672	PFAM Archaeal ATPase
Ava_2976	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_2980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_2981	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Ava_2982	COG0525	valine-tRNA ligase activity
Ava_2985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Ava_2993	COG0180	Tryptophanyl-tRNA synthetase
Ava_3000	COG0110	maltose O-acetyltransferase activity
Ava_3003	COG5002	protein histidine kinase activity
Ava_3004	COG5001	Diguanylate cyclase
Ava_3004	COG3706	GGDEF domain
Ava_3004	COG2203	Gaf domain
Ava_3004	COG4251	negative regulation of phosphorylation
Ava_3005	COG0784	Response regulator, receiver
Ava_3006	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ava_3009	COG0784	Response regulator, receiver
Ava_3009	COG2198	Histidine kinase
Ava_3009	COG2205	protein histidine kinase activity
Ava_3009	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_3010	COG1606	tRNA processing
Ava_3017	COG1132	(ABC) transporter
Ava_3020	COG0488	(ABC) transporter
Ava_3025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ava_3026	COG0659	secondary active sulfate transmembrane transporter activity
Ava_3028	COG0347	Belongs to the P(II) protein family
Ava_3029	COG0475	glutathione-regulated potassium exporter activity
Ava_3033	COG4999	Histidine kinase
Ava_3033	COG3850	Histidine kinase
Ava_3033	COG3437	response regulator, receiver
Ava_3033	COG2205	protein histidine kinase activity
Ava_3034	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Ava_3036	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_3036	COG0515	serine threonine protein kinase
Ava_3051	COG0741	lytic transglycosylase activity
Ava_3052	COG1410	methionine synthase
Ava_3052	COG0646	methionine synthase
Ava_3064	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Ava_3066	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_3071	COG1957	nucleoside hydrolase
Ava_3072	COG2197	response regulator
Ava_3073	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_3074	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ava_3076	COG0071	Belongs to the small heat shock protein (HSP20) family
Ava_3077	COG2076	Multidrug Resistance protein
Ava_3078	COG2319	Wd-40 repeat
Ava_3078	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_3079	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_3079	COG2319	Wd-40 repeat
Ava_3081	COG0571	ribonuclease III activity
Ava_3084	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ava_3084	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Ava_3085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ava_3086	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ava_3086	COG4651	solute:proton antiporter activity
Ava_3088	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ava_3089	COG3706	GGDEF domain
Ava_3089	COG0745	RESPONSE REGULATOR receiver
Ava_3091	COG0405	Gamma-glutamyltransferase
Ava_3100	COG0667	Aldo Keto reductase
Ava_3111	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Ava_3115	COG1295	ribonuclease BN
Ava_3117	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Ava_3118	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Ava_3119	COG0346	lactoylglutathione lyase activity
Ava_3126	COG1959	2 iron, 2 sulfur cluster binding
Ava_3127	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Ava_3132	COG0724	RNA recognition motif
Ava_3133	COG2326	polyphosphate kinase activity
Ava_3136	COG0157	Belongs to the NadC ModD family
Ava_3138	COG0564	pseudouridine synthase activity
Ava_3139	COG0824	Thioesterase
Ava_3146	COG0501	Belongs to the peptidase M48B family
Ava_3153	COG3385	transposase activity
Ava_3159	COG5002	protein histidine kinase activity
Ava_3165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Ava_3166	COG2201	protein-glutamate methylesterase activity
Ava_3170	COG2203	Gaf domain
Ava_3170	COG5001	Diguanylate cyclase
Ava_3170	COG3706	GGDEF domain
Ava_3170	COG4251	negative regulation of phosphorylation
Ava_3173	COG1022	Amp-dependent synthetase and ligase
Ava_3183	COG3240	lipase activity
Ava_3187	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_3190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_3192	COG0123	including yeast histone deacetylase and acetoin utilization protein
Ava_3193	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Ava_3194	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Ava_3195	COG1388	LysM domain
Ava_3195	COG4942	peptidase
Ava_3197	COG0501	Belongs to the peptidase M48B family
Ava_3199	COG0392	lysyltransferase activity
Ava_3199	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Ava_3203	COG0392	lysyltransferase activity
Ava_3204	COG2203	Gaf domain
Ava_3207	COG3852	Histidine kinase
Ava_3208	COG0701	Predicted permease
Ava_3213	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ava_3216	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ava_3224	COG2166	iron-sulfur cluster assembly
Ava_3225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ava_3226	COG5002	protein histidine kinase activity
Ava_3227	COG0151	Belongs to the GarS family
Ava_3228	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_3229	COG2076	Multidrug Resistance protein
Ava_3230	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Ava_3231	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ava_3232	COG1902	pentaerythritol trinitrate reductase activity
Ava_3234	COG3706	GGDEF domain
Ava_3247	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ava_3247	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Ava_3248	COG0515	serine threonine protein kinase
Ava_3248	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ava_3267	COG0732	type I restriction modification DNA specificity domain
Ava_3269	COG1487	ribonuclease activity
Ava_3275	COG5635	Nacht domain
Ava_3275	COG2319	Wd-40 repeat
Ava_3275	COG5635	Nacht domain
Ava_3275	COG2319	Wd-40 repeat
Ava_3277	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ava_3282	COG4372	Transposase
Ava_3284	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ava_3285	COG0131	Imidazoleglycerol-phosphate dehydratase
Ava_3286	COG1131	(ABC) transporter
Ava_3288	COG0330	HflC and HflK could
Ava_3289	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Ava_3291	COG1160	GTP binding
Ava_3294	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ava_3297	COG0113	porphobilinogen synthase activity
Ava_3301	COG0438	transferase activity, transferring glycosyl groups
Ava_3305	COG4783	chaperone-mediated protein folding
Ava_3306	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ava_3308	COG0515	serine threonine protein kinase
Ava_3308	COG3266	domain, Protein
Ava_3310	COG0515	serine threonine protein kinase
Ava_3310	COG3266	domain, Protein
Ava_3311	COG1429	ligase activity, forming nitrogen-metal bonds
Ava_3322	COG1598	PFAM Uncharacterised protein family UPF0150
Ava_3327	COG1247	-acetyltransferase
Ava_3330	COG0175	sulfate reduction
Ava_3333	COG0483	inositol monophosphate 1-phosphatase activity
Ava_3340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_3341	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ava_3342	COG0003	Pfam Anion-transporting ATPase
Ava_3351	COG0463	Glycosyl transferase, family 2
Ava_3352	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_3355	COG1091	dTDP-4-dehydrorhamnose reductase activity
Ava_3359	COG4106	trans-aconitate 2-methyltransferase activity
Ava_3360	COG0438	transferase activity, transferring glycosyl groups
Ava_3362	COG0784	Response regulator, receiver
Ava_3362	COG2205	protein histidine kinase activity
Ava_3365	COG3659	wide pore channel activity
Ava_3366	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ava_3367	COG0704	Plays a role in the regulation of phosphate uptake
Ava_3368	COG5002	protein histidine kinase activity
Ava_3369	COG0745	RESPONSE REGULATOR receiver
Ava_3378	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ava_3380	COG3937	granule-associated protein
Ava_3381	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ava_3382	COG0631	protein serine/threonine phosphatase activity
Ava_3384	COG0515	serine threonine protein kinase
Ava_3388	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ava_3388	COG0574	Belongs to the PEP-utilizing enzyme family
Ava_3389	COG1285	pathogenesis
Ava_3392	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_3393	COG1305	Transglutaminase-like
Ava_3397	COG0463	Glycosyl transferase, family 2
Ava_3398	COG2814	Major facilitator Superfamily
Ava_3402	COG2204	response regulator
Ava_3410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ava_3411	COG0438	transferase activity, transferring glycosyl groups
Ava_3418	COG1690	Belongs to the RtcB family
Ava_3419	COG2226	methyltransferase
Ava_3422	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Ava_3423	COG1166	arginine decarboxylase activity
Ava_3425	COG0861	Integral membrane protein TerC family
Ava_3428	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Ava_3429	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Ava_3430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Ava_3435	COG0706	membrane insertase activity
Ava_3440	COG0793	Belongs to the peptidase S41A family
Ava_3445	COG0438	transferase activity, transferring glycosyl groups
Ava_3449	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_3453	COG0745	RESPONSE REGULATOR receiver
Ava_3455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ava_3459	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_3460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ava_3464	COG0322	excinuclease ABC activity
Ava_3468	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ava_3468	COG0512	Glutamine amidotransferase of anthranilate synthase
Ava_3472	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ava_3474	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ava_3477	COG0850	regulation of cytokinetic process
Ava_3478	COG2894	cell division
Ava_3492	COG1857	crispr-associated protein
Ava_3498	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ava_3498	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Ava_3502	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Ava_3503	COG0464	growth
Ava_3504	COG1404	Belongs to the peptidase S8 family
Ava_3510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ava_3512	COG4948	Mandelate Racemase Muconate Lactonizing
Ava_3513	COG0494	nUDIX hydrolase
Ava_3515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ava_3515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ava_3516	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ava_3519	COG0351	phosphomethylpyrimidine kinase
Ava_3526	COG3852	Histidine kinase
Ava_3529	COG0697	spore germination
Ava_3530	COG0248	Ppx GppA phosphatase
Ava_3531	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ava_3534	COG1012	belongs to the aldehyde dehydrogenase family
Ava_3535	COG2815	serine threonine protein kinase
Ava_3535	COG0515	serine threonine protein kinase
Ava_3541	COG4251	negative regulation of phosphorylation
Ava_3545	COG0475	glutathione-regulated potassium exporter activity
Ava_3545	COG0589	response to stress
Ava_3546	COG1234	tRNA 3'-trailer cleavage
Ava_3548	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ava_3554	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ava_3555	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ava_3556	COG1027	Aspartate ammonia-lyase
Ava_3557	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_3565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_3569	COG0438	transferase activity, transferring glycosyl groups
Ava_3573	COG0438	transferase activity, transferring glycosyl groups
Ava_3575	COG1845	cytochrome c oxidase, subunit III
Ava_3576	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ava_3577	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ava_3582	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Ava_3583	COG2211	Major facilitator Superfamily
Ava_3584	COG0515	serine threonine protein kinase
Ava_3584	COG2815	serine threonine protein kinase
Ava_3591	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ava_3595	COG0668	transmembrane transport
Ava_3604	COG0740	serine-type endopeptidase activity
Ava_3606	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ava_3607	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ava_3608	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Ava_3609	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ava_3614	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Ava_3615	COG1012	belongs to the aldehyde dehydrogenase family
Ava_3616	COG0745	RESPONSE REGULATOR receiver
Ava_3616	COG3706	GGDEF domain
Ava_3623	COG1192	Involved in chromosome partitioning
Ava_3627	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ava_3630	COG0017	Asparaginyl-tRNA synthetase
Ava_3634	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ava_3637	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ava_3638	COG0577	efflux transmembrane transporter activity
Ava_3638	COG1136	(ABC) transporter
Ava_3645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Ava_3646	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ava_3647	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_3648	COG2048	Heterodisulfide reductase, subunit B
Ava_3649	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ava_3650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Ava_3651	COG0406	alpha-ribazole phosphatase activity
Ava_3653	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_3655	COG1116	anion transmembrane transporter activity
Ava_3655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_3656	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_3658	COG1201	RNA secondary structure unwinding
Ava_3661	COG4251	negative regulation of phosphorylation
Ava_3665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ava_3665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ava_3676	COG0024	Methionine aminopeptidase
Ava_3678	COG0612	Peptidase, M16
Ava_3683	COG0285	dihydrofolate synthase activity
Ava_3696	COG0432	Pfam Uncharacterised protein family UPF0047
Ava_3702	COG0640	Transcriptional regulator
Ava_3709	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Ava_3710	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Ava_3712	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ava_3713	COG0798	PFAM Bile acid sodium symporter
Ava_3716	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ava_3717	COG0523	cobalamin synthesis protein
Ava_3720	COG0312	modulator of DNA gyrase
Ava_3721	COG3852	Histidine kinase
Ava_3722	COG1366	Belongs to the anti-sigma-factor antagonist family
Ava_3723	COG0745	RESPONSE REGULATOR receiver
Ava_3730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ava_3732	COG0539	negative regulation of cytoplasmic translation
Ava_3733	COG0412	Dienelactone hydrolase
Ava_3734	COG2188	Transcriptional regulator
Ava_3741	COG3540	Alkaline phosphatase
Ava_3742	COG0300	oxidoreductase activity
Ava_3742	COG3000	fatty acid hydroxylase
Ava_3745	COG0584	glycerophosphoryl diester phosphodiesterase
Ava_3748	COG0587	DNA-directed DNA polymerase activity
Ava_3752	COG1554	hydrolase, family 65, central catalytic
Ava_3753	COG0438	transferase activity, transferring glycosyl groups
Ava_3755	COG0343	queuine tRNA-ribosyltransferase activity
Ava_3759	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ava_3763	COG3118	belongs to the thioredoxin family
Ava_3764	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_3765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ava_3767	COG5398	heme oxygenase
Ava_3772	COG1192	Involved in chromosome partitioning
Ava_3774	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ava_3775	COG2201	protein-glutamate methylesterase activity
Ava_3778	COG2203	Gaf domain
Ava_3778	COG0840	transmembrane signaling receptor activity
Ava_3779	COG2198	Histidine kinase
Ava_3779	COG0643	Histidine kinase
Ava_3781	COG1741	Belongs to the pirin family
Ava_3782	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ava_3784	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ava_3790	COG0358	DNA primase activity
Ava_3792	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ava_3792	COG0758	DNA mediated transformation
Ava_3797	COG2226	methyltransferase
Ava_3798	COG0306	phosphate transporter
Ava_3806	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Ava_3811	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ava_3812	COG3536	Protein conserved in bacteria
Ava_3815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Ava_3816	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Ava_3821	COG3546	catalase activity
Ava_3822	COG2261	transglycosylase associated protein
Ava_3823	COG4232	protein-disulfide reductase activity
Ava_3827	COG5398	heme oxygenase
Ava_3828	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ava_3832	COG2327	Polysaccharide pyruvyl transferase
Ava_3833	COG0617	tRNA 3'-terminal CCA addition
Ava_3835	COG1214	PFAM Peptidase M22, glycoprotease
Ava_3836	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ava_3841	COG0574	Belongs to the PEP-utilizing enzyme family
Ava_3841	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ava_3846	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Ava_3848	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Ava_3849	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Ava_3850	COG5002	protein histidine kinase activity
Ava_3852	COG4251	negative regulation of phosphorylation
Ava_3853	COG0784	Response regulator, receiver
Ava_3854	COG2205	protein histidine kinase activity
Ava_3859	COG2217	Heavy metal translocating P-type atpase
Ava_3860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ava_3863	COG0628	permease
Ava_3865	COG5002	protein histidine kinase activity
Ava_3867	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_3867	COG0515	serine threonine protein kinase
Ava_3876	COG0110	maltose O-acetyltransferase activity
Ava_3881	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ava_3882	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Ava_3892	COG2135	peptidase activity
Ava_3893	COG0625	glutathione transferase activity
Ava_3897	COG5592	hemerythrin HHE cation binding domain
Ava_3899	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ava_3902	COG2363	Small membrane protein
Ava_3903	COG4451	ribulose bisphosphate carboxylase, small
Ava_3903	COG0464	growth
Ava_3905	COG4451	ribulose bisphosphate carboxylase, small
Ava_3911	COG0531	amino acid
Ava_3917	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_3921	COG2124	cytochrome p450
Ava_3923	COG4782	Protein conserved in bacteria
Ava_3925	COG4636	protein conserved in cyanobacteria
Ava_3928	COG0582	viral genome integration into host DNA
Ava_3929	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_3930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_3932	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_3933	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_3936	COG5420	small protein containing a coiled-coil domain
Ava_3953	COG1045	serine acetyltransferase
Ava_3956	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ava_3957	COG5554	nitrogen fixation
Ava_3958	COG5554	nitrogen fixation
Ava_3963	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Ava_3966	COG0066	3-isopropylmalate dehydratase activity
Ava_3968	COG0300	oxidoreductase activity
Ava_3969	COG2264	protein methyltransferase activity
Ava_3975	COG0784	Response regulator, receiver
Ava_3975	COG5002	protein histidine kinase activity
Ava_3975	COG2198	Histidine kinase
Ava_3980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ava_3987	COG0318	PFAM AMP-dependent synthetase and ligase
Ava_3995	COG0515	serine threonine protein kinase
Ava_3995	COG2815	serine threonine protein kinase
Ava_3996	COG0737	Belongs to the 5'-nucleotidase family
Ava_4014	COG1940	carbohydrate kinase activity
Ava_4016	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Ava_4018	COG0742	ribosomal rna small subunit methyltransferase
Ava_4020	COG2010	Cytochrome c
Ava_4023	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ava_4024	COG0412	Dienelactone hydrolase
Ava_4028	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_4035	COG0778	Nitroreductase
Ava_4037	COG1309	transcriptional regulator
Ava_4038	COG1122	ATPase activity
Ava_4041	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ava_4042	COG1910	domain protein
Ava_4047	COG1294	oxidase, subunit
Ava_4048	COG1271	oxidase subunit
Ava_4051	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_4059	COG3659	wide pore channel activity
Ava_4063	COG2124	cytochrome p450
Ava_4063	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Ava_4066	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4074	COG0489	protein tyrosine kinase activity
Ava_4077	COG2873	o-acetylhomoserine
Ava_4078	COG2391	methyltransferase activity
Ava_4079	COG2897	thiosulfate sulfurtransferase activity
Ava_4083	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_4086	COG5002	protein histidine kinase activity
Ava_4094	COG1473	amidohydrolase
Ava_4095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ava_4105	COG1136	(ABC) transporter
Ava_4106	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_4106	COG0515	serine threonine protein kinase
Ava_4108	COG0604	alcohol dehydrogenase
Ava_4108	COG3321	synthase
Ava_4110	COG4249	Peptidase C14 caspase catalytic subunit p20
Ava_4110	COG2319	Wd-40 repeat
Ava_4111	COG1881	PFAM PEBP family protein
Ava_4115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ava_4123	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ava_4130	COG3540	Alkaline phosphatase
Ava_4135	COG2205	protein histidine kinase activity
Ava_4135	COG0784	Response regulator, receiver
Ava_4139	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ava_4140	COG3659	wide pore channel activity
Ava_4141	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ava_4145	COG0667	Aldo Keto reductase
Ava_4146	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4147	COG1132	(ABC) transporter
Ava_4148	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4149	COG2203	Gaf domain
Ava_4149	COG3706	GGDEF domain
Ava_4149	COG5001	Diguanylate cyclase
Ava_4149	COG4251	negative regulation of phosphorylation
Ava_4152	COG0412	Dienelactone hydrolase
Ava_4153	COG0778	Nitroreductase
Ava_4154	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4155	COG0626	cystathionine gamma-synthase activity
Ava_4157	COG0436	Aminotransferase
Ava_4163	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ava_4167	COG2442	InterPro IPR007367
Ava_4169	COG4804	nuclease activity
Ava_4176	COG1518	maintenance of DNA repeat elements
Ava_4177	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Ava_4182	COG2831	hemolysin activation secretion protein
Ava_4203	COG0589	response to stress
Ava_4205	COG0268	Binds directly to 16S ribosomal RNA
Ava_4206	COG0084	hydrolase, TatD family'
Ava_4210	COG3239	Fatty acid desaturase
Ava_4211	COG3239	Fatty acid desaturase
Ava_4213	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Ava_4214	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
Ava_4215	COG0363	glucosamine-6-phosphate deaminase activity
Ava_4216	COG1716	ATPase activity
Ava_4218	COG2385	sporulation resulting in formation of a cellular spore
Ava_4221	COG0170	dolichyl monophosphate biosynthetic process
Ava_4223	COG1836	PFAM Integral membrane protein DUF92
Ava_4226	COG1404	Belongs to the peptidase S8 family
Ava_4229	COG4636	protein conserved in cyanobacteria
Ava_4230	COG1131	(ABC) transporter
Ava_4234	COG0788	formyltetrahydrofolate deformylase activity
Ava_4235	COG2217	Heavy metal translocating P-type atpase
Ava_4237	COG0789	Transcriptional regulator
Ava_4238	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ava_4239	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ava_4240	COG3119	arylsulfatase activity
Ava_4243	COG5554	nitrogen fixation
Ava_4244	COG0535	radical SAM domain protein
Ava_4244	COG1433	Dinitrogenase iron-molybdenum cofactor
Ava_4251	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Ava_4264	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Ava_4267	COG3706	GGDEF domain
Ava_4267	COG2203	Gaf domain
Ava_4267	COG5001	Diguanylate cyclase
Ava_4267	COG4251	negative regulation of phosphorylation
Ava_4268	COG0003	Pfam Anion-transporting ATPase
Ava_4276	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Ava_4279	COG0121	glutamine amidotransferase
Ava_4280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ava_4281	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Ava_4284	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ava_4290	COG1619	proteins homologs of microcin C7 resistance protein MccF
Ava_4292	COG0415	Belongs to the DNA photolyase family
Ava_4298	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ava_4300	COG1845	cytochrome c oxidase, subunit III
Ava_4308	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Ava_4309	COG0612	Peptidase, M16
Ava_4310	COG0612	Peptidase, M16
Ava_4312	COG1950	PFAM Membrane protein of
Ava_4317	COG0702	epimerase
Ava_4319	COG0596	Alpha beta hydrolase
Ava_4321	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Ava_4322	COG1937	Protein conserved in bacteria
Ava_4323	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_4325	COG4191	Histidine kinase
Ava_4326	COG5002	protein histidine kinase activity
Ava_4328	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_4331	COG0697	spore germination
Ava_4335	COG4106	trans-aconitate 2-methyltransferase activity
Ava_4339	COG1940	carbohydrate kinase activity
Ava_4342	COG1132	(ABC) transporter
Ava_4344	COG0784	Response regulator, receiver
Ava_4345	COG4251	negative regulation of phosphorylation
Ava_4345	COG4251	negative regulation of phosphorylation
Ava_4348	COG0542	response to heat
Ava_4350	COG0095	Lipoate-protein ligase
Ava_4354	COG1702	phosphate starvation-inducible protein PhoH
Ava_4358	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ava_4362	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ava_4366	COG0006	proline dipeptidase activity
Ava_4367	COG0384	phenazine biosynthesis protein PhzF
Ava_4370	COG0612	Peptidase, M16
Ava_4371	COG0612	Peptidase, M16
Ava_4381	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ava_4385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ava_4393	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ava_4401	COG3852	Histidine kinase
Ava_4410	COG0505	Belongs to the CarA family
Ava_4413	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ava_4415	COG2267	carboxylic ester hydrolase activity
Ava_4422	COG1741	Belongs to the pirin family
Ava_4423	COG0783	Belongs to the Dps family
Ava_4424	COG1773	rubredoxin
Ava_4426	COG2831	hemolysin activation secretion protein
Ava_4427	COG2130	NADP-dependent
Ava_4428	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ava_4428	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ava_4431	COG0745	RESPONSE REGULATOR receiver
Ava_4432	COG5002	protein histidine kinase activity
Ava_4433	COG3852	Histidine kinase
Ava_4435	COG1902	pentaerythritol trinitrate reductase activity
Ava_4436	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ava_4437	COG0640	Transcriptional regulator
Ava_4438	COG1121	(ABC) transporter
Ava_4439	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ava_4440	COG3659	wide pore channel activity
Ava_4443	COG0123	including yeast histone deacetylase and acetoin utilization protein
Ava_4449	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ava_4455	COG2267	carboxylic ester hydrolase activity
Ava_4457	COG2202	Pas domain
Ava_4457	COG2205	protein histidine kinase activity
Ava_4463	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Ava_4464	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ava_4466	COG0583	DNA-binding transcription factor activity
Ava_4469	COG4451	ribulose bisphosphate carboxylase, small
Ava_4469	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Ava_4470	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Ava_4471	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ava_4472	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ava_4473	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ava_4474	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ava_4478	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Ava_4484	COG0339	signal peptide processing
Ava_4486	COG0589	response to stress
Ava_4489	COG2815	serine threonine protein kinase
Ava_4489	COG0515	serine threonine protein kinase
Ava_4496	COG0693	protein deglycase activity
Ava_4504	COG0515	serine threonine protein kinase
Ava_4504	COG2815	serine threonine protein kinase
Ava_4506	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ava_4506	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ava_4507	COG2897	thiosulfate sulfurtransferase activity
Ava_4508	COG4804	nuclease activity
Ava_4509	COG1160	GTP binding
Ava_4511	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Ava_4514	COG0581	inorganic phosphate transmembrane transporter activity
Ava_4515	COG0573	inorganic phosphate transmembrane transporter activity
Ava_4516	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ava_4517	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ava_4518	COG2197	response regulator
Ava_4525	COG0154	amidase activity
Ava_4535	COG0583	DNA-binding transcription factor activity
Ava_4536	COG3659	wide pore channel activity
Ava_4540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4541	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ava_4542	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_4542	COG1116	anion transmembrane transporter activity
Ava_4543	COG1116	anion transmembrane transporter activity
Ava_4544	COG0243	molybdopterin cofactor binding
Ava_4553	COG4106	trans-aconitate 2-methyltransferase activity
Ava_4555	COG0247	lactate metabolic process
Ava_4556	COG0277	FAD linked oxidase domain protein
Ava_4568	COG0589	response to stress
Ava_4569	COG0574	Belongs to the PEP-utilizing enzyme family
Ava_4569	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ava_4572	COG1132	(ABC) transporter
Ava_4574	COG0811	peptide transport
Ava_4575	COG0848	biopolymer transport protein
Ava_4581	COG0408	coproporphyrinogen oxidase activity
Ava_4583	COG0489	protein tyrosine kinase activity
Ava_4584	COG0772	Belongs to the SEDS family
Ava_4587	COG0589	response to stress
Ava_4587	COG0475	glutathione-regulated potassium exporter activity
Ava_4588	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ava_4589	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Ava_4590	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ava_4604	COG0409	Hydrogenase expression formation protein
Ava_4608	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ava_4610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_4611	COG0730	response to heat
Ava_4620	COG0768	penicillin binding
Ava_4625	COG0012	GTP binding
Ava_4629	COG0363	glucosamine-6-phosphate deaminase activity
Ava_4630	COG0546	phosphoglycolate phosphatase activity
Ava_4631	COG5002	protein histidine kinase activity
Ava_4631	COG0784	Response regulator, receiver
Ava_4632	COG0731	radical SAM domain protein
Ava_4636	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ava_4637	COG0492	ferredoxin-NADP+ reductase activity
Ava_4638	COG1175	transmembrane transport
Ava_4641	COG0330	HflC and HflK could
Ava_4642	COG0724	RNA recognition motif
Ava_4644	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
Ava_4649	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ava_4652	COG0589	response to stress
Ava_4657	COG1034	ATP synthesis coupled electron transport
Ava_4659	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ava_4661	COG3259	Nickel-dependent hydrogenase
Ava_4664	COG0045	succinate-CoA ligase (ADP-forming) activity
Ava_4664	COG1042	CoA-binding domain protein
Ava_4664	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ava_4666	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Ava_4667	COG4221	oxidoreductase activity
Ava_4668	COG2226	methyltransferase
Ava_4671	COG1657	PFAM Prenyltransferase squalene oxidase
Ava_4675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ava_4678	COG3237	CsbD-like
Ava_4680	COG0556	nucleotide-excision repair
Ava_4689	COG1196	nuclear chromosome segregation
Ava_4690	COG1252	NADH dehydrogenase
Ava_4691	COG1252	NADH dehydrogenase
Ava_4693	COG0625	glutathione transferase activity
Ava_4694	COG3631	Ketosteroid isomerase-related protein
Ava_4695	COG0589	response to stress
Ava_4696	COG2205	protein histidine kinase activity
Ava_4696	COG0784	Response regulator, receiver
Ava_4699	COG0438	transferase activity, transferring glycosyl groups
Ava_4701	COG5002	protein histidine kinase activity
Ava_4701	COG0784	Response regulator, receiver
Ava_4702	COG0745	RESPONSE REGULATOR receiver
Ava_4702	COG3706	GGDEF domain
Ava_4708	COG2267	carboxylic ester hydrolase activity
Ava_4709	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ava_4710	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Ava_4712	COG4208	sulfate ABC transporter
Ava_4713	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Ava_4714	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Ava_4715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Ava_4720	COG0121	glutamine amidotransferase
Ava_4721	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ava_4723	COG5002	protein histidine kinase activity
Ava_4727	COG0584	glycerophosphoryl diester phosphodiesterase
Ava_4735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ava_4740	COG2207	Transcriptional regulator
Ava_4741	COG0300	oxidoreductase activity
Ava_4741	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ava_4741	COG4221	oxidoreductase activity
Ava_4741	COG3321	synthase
Ava_4744	COG3321	synthase
Ava_4744	COG0604	alcohol dehydrogenase
Ava_4745	COG3321	synthase
Ava_4745	COG0604	alcohol dehydrogenase
Ava_4747	COG0604	alcohol dehydrogenase
Ava_4747	COG3321	synthase
Ava_4751	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ava_4751	COG2070	2-Nitropropane dioxygenase
Ava_4754	COG0314	molybdopterin synthase activity
Ava_4759	COG0778	Nitroreductase
Ava_4760	COG1902	pentaerythritol trinitrate reductase activity
Ava_4761	COG3118	belongs to the thioredoxin family
Ava_4762	COG0640	Transcriptional regulator
Ava_4764	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_4764	COG0515	serine threonine protein kinase
Ava_4772	COG1803	Methylglyoxal synthase
Ava_4772	COG1597	lipid kinase activity
Ava_4774	COG0181	hydroxymethylbilane synthase activity
Ava_4776	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Ava_4779	COG3437	response regulator, receiver
Ava_4779	COG3850	Histidine kinase
Ava_4779	COG4999	Histidine kinase
Ava_4779	COG2205	protein histidine kinase activity
Ava_4780	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_4781	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Ava_4785	COG0517	IMP dehydrogenase activity
Ava_4785	COG1994	Peptidase M50
Ava_4794	COG1562	ergosterol biosynthetic process
Ava_4795	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Ava_4795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ava_4797	COG0726	polysaccharide deacetylase
Ava_4804	COG0569	domain protein
Ava_4805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ava_4806	COG2226	methyltransferase
Ava_4807	COG2205	protein histidine kinase activity
Ava_4807	COG0784	Response regulator, receiver
Ava_4813	COG2319	Wd-40 repeat
Ava_4813	COG1672	PFAM Archaeal ATPase
Ava_4824	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Ava_4826	COG4636	protein conserved in cyanobacteria
Ava_4829	COG3842	ATPase activity
Ava_4830	COG0515	serine threonine protein kinase
Ava_4831	COG0538	isocitrate dehydrogenase activity
Ava_4832	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ava_4840	COG1216	Glycosyl transferase, family 2
Ava_4840	COG1442	glycosyl transferase family 8
Ava_4841	COG0438	transferase activity, transferring glycosyl groups
Ava_4842	COG3307	-O-antigen
Ava_4843	COG0438	transferase activity, transferring glycosyl groups
Ava_4844	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ava_4847	COG1472	Belongs to the glycosyl hydrolase 3 family
Ava_4855	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_4855	COG0515	serine threonine protein kinase
Ava_4856	COG1104	cysteine desulfurase activity
Ava_4858	COG3265	gluconokinase activity
Ava_4862	COG0515	serine threonine protein kinase
Ava_4863	COG0515	serine threonine protein kinase
Ava_4866	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ava_4869	COG2337	Toxic component of a toxin-antitoxin (TA) module
Ava_4874	COG0432	Pfam Uncharacterised protein family UPF0047
Ava_4876	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Ava_4880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ava_4884	COG0582	viral genome integration into host DNA
Ava_4890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ava_4890	COG0512	Glutamine amidotransferase of anthranilate synthase
Ava_4896	COG0784	Response regulator, receiver
Ava_4897	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ava_4900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_4906	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_4907	COG2501	S4 domain
Ava_4914	COG0745	RESPONSE REGULATOR receiver
Ava_4918	COG0140	phosphoribosyl-ATP diphosphatase activity
Ava_4918	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ava_4923	COG0515	serine threonine protein kinase
Ava_4923	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_4926	COG1619	proteins homologs of microcin C7 resistance protein MccF
Ava_4927	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Ava_4929	COG0739	heme binding
Ava_4929	COG0741	lytic transglycosylase activity
Ava_4929	COG1196	nuclear chromosome segregation
Ava_4931	COG1376	ErfK ybiS ycfS ynhG family protein
Ava_4933	COG1595	DNA-templated transcription, initiation
Ava_4937	COG0590	tRNA wobble adenosine to inosine editing
Ava_4952	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Ava_4953	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Ava_4958	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Ava_4967	COG4771	TonB-dependent receptor
Ava_4978	COG0697	spore germination
Ava_4981	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ava_4981	COG0678	peroxiredoxin activity
Ava_4987	COG1122	ATPase activity
Ava_4989	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ava_4993	COG4172	Belongs to the ABC transporter superfamily
Ava_4994	COG1252	NADH dehydrogenase
Ava_4995	COG1132	(ABC) transporter
Ava_4996	COG0408	coproporphyrinogen oxidase activity
Ava_4998	COG0625	glutathione transferase activity
Ava_5000	COG0644	oxidoreductase
Ava_5002	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_5003	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_5009	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
Ava_5010	COG0667	Aldo Keto reductase
Ava_5011	COG0625	glutathione transferase activity
Ava_5012	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ava_5016	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ava_5017	COG1045	serine acetyltransferase
Ava_5018	COG1959	2 iron, 2 sulfur cluster binding
Ava_5019	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ava_5024	COG0583	DNA-binding transcription factor activity
Ava_5026	COG0730	response to heat
Ava_5027	COG0671	phosphoesterase, PA-phosphatase related
Ava_5029	COG0330	HflC and HflK could
Ava_5032	COG2319	Wd-40 repeat
Ava_5032	COG3903	Transcriptional regulator
Ava_5033	COG1335	isochorismatase
Ava_5034	COG3224	Antibiotic biosynthesis monooxygenase
Ava_5042	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ava_5043	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ava_5047	COG0352	thiamine-phosphate diphosphorylase activity
Ava_5054	COG0515	serine threonine protein kinase
Ava_5054	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_5055	COG1177	transmembrane transport
Ava_5057	COG0438	transferase activity, transferring glycosyl groups
Ava_5058	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Ava_5060	COG2095	MarC family integral membrane protein
Ava_5061	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ava_5064	COG2217	Heavy metal translocating P-type atpase
Ava_5067	COG0242	peptide deformylase activity
Ava_5068	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ava_A0002	COG0631	protein serine/threonine phosphatase activity
Ava_A0009	COG3266	domain, Protein
Ava_A0009	COG0515	serine threonine protein kinase
Ava_A0021	COG1475	DNA binding
Ava_A0022	COG1192	Involved in chromosome partitioning
Ava_A0029	COG0305	Participates in initiation and elongation during chromosome replication
Ava_A0029	COG1372	Participates in initiation and elongation during chromosome replication
Ava_A0029	COG0305	Participates in initiation and elongation during chromosome replication
Ava_A0029	COG1372	Participates in initiation and elongation during chromosome replication
Ava_B0009	COG0515	serine threonine protein kinase
Ava_B0009	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_B0010	COG2319	Wd-40 repeat
Ava_B0010	COG3903	Transcriptional regulator
Ava_B0028	COG2205	protein histidine kinase activity
Ava_B0029	COG2197	response regulator
Ava_B0036	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_B0062	COG0129	dihydroxy-acid dehydratase activity
Ava_B0068	COG0583	DNA-binding transcription factor activity
Ava_B0069	COG1061	Type III restriction enzyme res subunit
Ava_B0091	COG1715	Restriction endonuclease
Ava_B0104	COG0659	secondary active sulfate transmembrane transporter activity
Ava_B0106	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ava_B0112	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ava_B0132	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
Ava_B0134	COG4245	von Willebrand factor, type A
Ava_B0142	COG4974	Belongs to the 'phage' integrase family
Ava_B0143	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Ava_B0145	COG1858	cytochrome C peroxidase
Ava_B0151	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ava_B0152	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ava_B0153	COG1120	ATPase activity
Ava_B0162	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ava_B0163	COG1120	ATPase activity
Ava_B0165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ava_B0166	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Ava_B0169	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Ava_B0172	COG1271	oxidase subunit
Ava_B0173	COG1294	oxidase, subunit
Ava_B0175	COG1271	oxidase subunit
Ava_B0177	COG1845	cytochrome c oxidase, subunit III
Ava_B0179	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ava_B0185	COG4771	TonB-dependent receptor
Ava_B0189	COG4974	Belongs to the 'phage' integrase family
Ava_B0190	COG2205	protein histidine kinase activity
Ava_B0191	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_B0191	COG2205	protein histidine kinase activity
Ava_B0197	COG2205	protein histidine kinase activity
Ava_B0200	COG3659	wide pore channel activity
Ava_B0202	COG0515	serine threonine protein kinase
Ava_B0202	COG1357	PFAM Pentapeptide repeats (8 copies)
Ava_B0204	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Ava_B0206	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Ava_B0207	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Ava_B0208	COG5002	protein histidine kinase activity
Ava_B0209	COG2197	response regulator
Ava_B0214	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ava_B0220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ava_B0222	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ava_B0223	COG1121	(ABC) transporter
Ava_B0224	COG3443	Belongs to the bacterial solute-binding protein 9 family
Ava_B0224	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ava_B0225	COG0113	porphobilinogen synthase activity
Ava_B0226	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ava_B0228	COG0523	cobalamin synthesis protein
Ava_B0229	COG2226	methyltransferase
Ava_B0239	COG3659	wide pore channel activity
Ava_B0243	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ava_B0282	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ava_B0282	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ava_B0294	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
Ava_B0304	COG1104	cysteine desulfurase activity
Ava_B0306	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ava_B0307	COG1061	Type III restriction enzyme res subunit
Ava_B0328	COG1372	Participates in initiation and elongation during chromosome replication
Ava_B0328	COG0305	Participates in initiation and elongation during chromosome replication
Ava_C0003	COG5285	phytanoyl-CoA dioxygenase
Ava_C0013	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ava_C0023	COG3659	wide pore channel activity
Ava_C0024	COG2814	Major facilitator Superfamily
Ava_C0027	COG2207	Transcriptional regulator
Ava_C0030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ava_C0058	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ava_C0059	COG1216	Glycosyl transferase, family 2
Ava_C0059	COG1442	glycosyl transferase family 8
Ava_C0060	COG1205	dead DEAH box helicase
Ava_C0060	COG1111	helicase
Ava_C0075	COG0592	DNA-directed DNA polymerase activity
Ava_C0076	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ava_C0084	COG0470	DNA polymerase III
Ava_C0087	COG3335	DDE superfamily endonuclease
Ava_C0090	COG0776	regulation of translation
Ava_C0099	COG1266	CAAX protease self-immunity
Ava_C0106	COG1335	isochorismatase
Ava_C0107	COG2267	carboxylic ester hydrolase activity
Ava_C0109	COG1028	Short-chain dehydrogenase reductase Sdr
Ava_C0111	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ava_C0111	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ava_C0112	COG4221	oxidoreductase activity
Ava_C0115	COG2207	Transcriptional regulator
Ava_C0116	COG2197	response regulator
Ava_C0117	COG2815	serine threonine protein kinase
Ava_C0117	COG0515	serine threonine protein kinase
Ava_C0121	COG1192	Involved in chromosome partitioning
Ava_C0123	COG1475	DNA binding
Ava_C0125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Ava_C0126	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Ava_C0127	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Ava_C0128	COG2080	2 iron, 2 sulfur cluster binding
Ava_C0132	COG0542	response to heat
Ava_C0134	COG0484	heat shock protein binding
Ava_C0138	COG0656	L-ascorbic acid biosynthetic process
Ava_C0141	COG0443	Heat shock 70 kDa protein
Ava_C0142	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ava_C0142	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ava_C0145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ava_C0148	COG1902	pentaerythritol trinitrate reductase activity
Ava_C0152	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Ava_C0156	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ava_C0156	COG2198	Histidine kinase
Ava_C0156	COG2205	protein histidine kinase activity
Ava_C0156	COG0784	Response regulator, receiver
Ava_C0160	COG3385	transposase activity
Ava_C0162	COG0745	RESPONSE REGULATOR receiver
Ava_C0164	COG0716	FMN binding
Ava_C0174	COG0574	Belongs to the PEP-utilizing enzyme family
Ava_C0174	COG3848	Pyruvate phosphate dikinase
Ava_C0194	COG2197	response regulator
Ava_C0210	COG0739	heme binding
Ava_C0233	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ava_D0015	COG0776	regulation of translation
Ava_D0022	COG1191	sigma factor activity
Ava_D0026	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Ava_D0049	COG0582	viral genome integration into host DNA