locus-tag	class	description
K529_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K529_000015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K529_000040	COG2003	Belongs to the UPF0758 family
K529_000045	COG0484	heat shock protein binding
K529_000050	COG0443	Heat shock 70 kDa protein
K529_000070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K529_000080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_000105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K529_000110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K529_000115	COG1137	ATPase activity
K529_000120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K529_000140	COG4774	siderophore transport
K529_000145	COG0569	domain protein
K529_000150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_000160	COG1070	Carbohydrate kinase
K529_000165	COG2115	Belongs to the xylose isomerase family
K529_000175	COG1858	cytochrome C peroxidase
K529_000180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K529_000190	COG3293	Transposase
K529_000195	COG3263	regulation of cellular component size
K529_000200	COG4608	Belongs to the ABC transporter superfamily
K529_000205	COG0444	Belongs to the ABC transporter superfamily
K529_000210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_000215	COG0601	transmembrane transport
K529_000220	COG0747	negative chemotaxis
K529_000230	COG1522	sequence-specific DNA binding
K529_000240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_000250	COG1953	Uracil, thiamine, allantoin
K529_000255	COG1132	(ABC) transporter
K529_000260	COG2081	HI0933 family
K529_000265	COG0625	glutathione transferase activity
K529_000280	COG0495	leucyl-tRNA aminoacylation
K529_000295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K529_000310	COG0745	RESPONSE REGULATOR receiver
K529_000325	COG3118	belongs to the thioredoxin family
K529_000330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K529_000335	COG2835	tetraacyldisaccharide 4'-kinase activity
K529_000340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_000345	COG0154	amidase activity
K529_000355	COG1674	ftsk spoiiie
K529_000375	COG0405	Gamma-glutamyltransferase
K529_000380	COG2172	sigma factor antagonist activity
K529_000390	COG0183	Belongs to the thiolase family
K529_000395	COG1956	GAF domain-containing protein
K529_000425	COG0564	pseudouridine synthase activity
K529_000440	COG0450	alkyl hydroperoxide reductase
K529_000450	COG1185	polyribonucleotide nucleotidyltransferase activity
K529_000460	COG0523	cobalamin synthesis protein
K529_000465	COG1629	transport
K529_000470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K529_000475	COG0596	Alpha beta hydrolase
K529_000490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K529_000500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K529_000505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K529_000525	COG0138	bifunctional purine biosynthesis protein purh
K529_000530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K529_000540	COG0612	Peptidase, M16
K529_000545	COG0612	Peptidase, M16
K529_000550	COG1012	belongs to the aldehyde dehydrogenase family
K529_000560	COG0803	Belongs to the bacterial solute-binding protein 9 family
K529_000565	COG1121	(ABC) transporter
K529_000570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_000570	COG1321	iron dependent repressor
K529_000575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_000610	COG0625	glutathione transferase activity
K529_000625	COG0745	RESPONSE REGULATOR receiver
K529_000675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K529_000680	COG1178	ABC-type Fe3 transport system permease component
K529_000690	COG1840	ABC-type Fe3 transport system, periplasmic component
K529_000695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K529_000710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K529_000720	COG0284	orotidine-5'-phosphate decarboxylase activity
K529_000730	COG0069	glutamate synthase activity
K529_000735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K529_000740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K529_000775	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_000810	COG0300	oxidoreductase activity
K529_000820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K529_000830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K529_000850	COG0250	Participates in transcription elongation, termination and antitermination
K529_000860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K529_000865	COG0081	regulation of translation
K529_000875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K529_000880	COG0222	ribosome binding
K529_000885	COG0085	RNA polymerase activity
K529_000890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K529_000900	COG0697	spore germination
K529_000910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K529_000915	COG0049	tRNA binding
K529_000920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K529_000925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K529_000930	COG0656	L-ascorbic acid biosynthetic process
K529_000950	COG0051	transcription antitermination factor activity, RNA binding
K529_000955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K529_000960	COG0088	Forms part of the polypeptide exit tunnel
K529_000965	COG0089	rRNA binding
K529_000980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K529_000985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K529_000990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K529_000995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K529_001000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K529_001005	COG0625	glutathione transferase activity
K529_001035	COG0255	Belongs to the universal ribosomal protein uL29 family
K529_001040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K529_001045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K529_001050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K529_001055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K529_001060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K529_001065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K529_001070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K529_001075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K529_001080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K529_001085	COG1841	ribosomal large subunit assembly
K529_001105	COG0200	Binds to the 23S rRNA
K529_001110	COG0201	protein transport
K529_001115	COG0563	adenylate kinase activity
K529_001120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K529_001125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K529_001130	COG0202	RNA polymerase activity
K529_001135	COG0203	ribosomal protein L17
K529_001140	COG2824	Alkylphosphonate utilization operon protein PhnA
K529_001145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_001160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K529_001170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K529_001175	COG2132	Multicopper oxidase
K529_001180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K529_001185	COG0564	pseudouridine synthase activity
K529_001200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_001205	COG4597	amino acid ABC transporter
K529_001210	COG0765	amino acid transport
K529_001215	COG1126	abc transporter atp-binding protein
K529_001235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K529_001240	COG1028	Short-chain dehydrogenase reductase Sdr
K529_001255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K529_001265	COG0706	membrane insertase activity
K529_001275	COG0037	tRNA processing
K529_001285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K529_001290	COG0594	ribonuclease P activity
K529_001295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K529_001300	COG0398	Pfam SNARE associated Golgi protein
K529_001310	COG3852	Histidine kinase
K529_001315	COG1802	Transcriptional regulator
K529_001330	COG4650	regulator
K529_001360	COG0714	Associated with various cellular activities
K529_001375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K529_001380	COG2011	ABC-type metal ion transport system permease component
K529_001385	COG1464	Belongs to the NlpA lipoprotein family
K529_001390	COG1309	transcriptional regulator
K529_001405	COG0778	Nitroreductase
K529_001405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K529_001410	COG1920	GTP binding
K529_001415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K529_001420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K529_001425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K529_001435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K529_001450	COG1953	Uracil, thiamine, allantoin
K529_001475	COG2205	protein histidine kinase activity
K529_001475	COG0784	Response regulator, receiver
K529_001480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K529_001485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_001490	COG4558	Periplasmic binding protein
K529_001495	COG3720	iron ion transport
K529_001510	COG0811	peptide transport
K529_001515	COG0848	biopolymer transport protein
K529_001540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_001560	COG0840	transmembrane signaling receptor activity
K529_001565	COG1024	Enoyl-CoA hydratase
K529_001565	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_001570	COG0183	Belongs to the thiolase family
K529_001585	COG0837	glucose binding
K529_001600	COG0730	response to heat
K529_001625	COG1072	(Pantothenic acid kinase))
K529_001650	COG0800	Aldolase
K529_001655	COG0129	dihydroxy-acid dehydratase activity
K529_001660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K529_001665	COG0166	Belongs to the GPI family
K529_001670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K529_001675	COG0830	nickel cation binding
K529_001680	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
K529_001690	COG0804	urea catabolic process
K529_001695	COG0832	Belongs to the urease beta subunit family
K529_001705	COG0831	urea catabolic process
K529_001710	COG0829	nickel cation binding
K529_001715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_001725	COG2936	dipeptidyl-peptidase activity
K529_001745	COG0489	protein tyrosine kinase activity
K529_001775	COG0243	molybdopterin cofactor binding
K529_001775	COG3383	formate dehydrogenase (NAD+) activity
K529_001780	COG0437	4 iron, 4 sulfur cluster binding
K529_001785	COG2864	formate dehydrogenase
K529_001795	COG2204	response regulator
K529_001800	COG3852	Histidine kinase
K529_001805	COG1028	Short-chain dehydrogenase reductase Sdr
K529_001810	COG0300	oxidoreductase activity
K529_001830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K529_001840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K529_001845	COG1595	DNA-templated transcription, initiation
K529_001850	COG3806	Anti-sigma factor
K529_001865	COG3811	Belongs to the UPF0386 family
K529_001875	COG1215	transferase activity, transferring glycosyl groups
K529_001885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_001890	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_001920	COG1175	transmembrane transport
K529_001935	COG0840	transmembrane signaling receptor activity
K529_001955	COG2030	dehydratase
K529_001955	COG1012	belongs to the aldehyde dehydrogenase family
K529_001960	COG1024	Enoyl-CoA hydratase
K529_001965	COG2050	protein possibly involved in aromatic compounds catabolism
K529_001985	COG2885	chlorophyll binding
K529_001990	COG0180	Tryptophanyl-tRNA synthetase
K529_002005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K529_002015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K529_002020	COG0792	nuclease activity
K529_002035	COG0606	chelatase, subunit chli
K529_002065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K529_002085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K529_002090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_002095	COG0765	amino acid transport
K529_002105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K529_002115	COG0583	DNA-binding transcription factor activity
K529_002120	COG0772	Belongs to the SEDS family
K529_002125	COG0768	penicillin binding
K529_002150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K529_002180	COG0405	Gamma-glutamyltransferase
K529_002185	COG0277	FAD linked oxidase domain protein
K529_002220	COG0667	Aldo Keto reductase
K529_002225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K529_002235	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_002240	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_002245	COG3845	ABC transporter
K529_002255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_002265	COG0659	secondary active sulfate transmembrane transporter activity
K529_002275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K529_002300	COG1028	Short-chain dehydrogenase reductase Sdr
K529_002305	COG0698	ribose 5-phosphate isomerase
K529_002315	COG0752	glycyl-tRNA synthetase alpha subunit
K529_002325	COG0751	glycine-tRNA ligase activity
K529_002330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K529_002330	COG0574	Belongs to the PEP-utilizing enzyme family
K529_002340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K529_002345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K529_002350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K529_002360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K529_002365	COG1522	sequence-specific DNA binding
K529_002370	COG1522	sequence-specific DNA binding
K529_002395	COG1802	Transcriptional regulator
K529_002400	COG1215	transferase activity, transferring glycosyl groups
K529_002405	COG0505	Belongs to the CarA family
K529_002410	COG1610	YqeY-like protein
K529_002425	COG0537	adenosine 5'-monophosphoramidase activity
K529_002430	COG0346	lactoylglutathione lyase activity
K529_002435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_002440	COG3046	protein related to deoxyribodipyrimidine photolyase
K529_002460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_002470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_002485	COG1959	2 iron, 2 sulfur cluster binding
K529_002495	COG4181	ATPase activity
K529_002550	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K529_002565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K529_002595	COG4136	ATPase activity
K529_002600	COG4135	transport system, permease component
K529_002605	COG4134	Bacterial extracellular solute-binding protein
K529_002610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K529_002615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K529_002625	COG0583	DNA-binding transcription factor activity
K529_002635	COG0625	glutathione transferase activity
K529_002660	COG1024	Enoyl-CoA hydratase
K529_002665	COG1960	acyl-CoA dehydrogenase activity
K529_002690	COG0411	ABC transporter
K529_002730	COG3483	tryptophan 2,3-dioxygenase activity
K529_002760	COG1648	precorrin-2 dehydrogenase activity
K529_002760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K529_002765	COG1797	cobyrinic acid a,c-diamide synthase activity
K529_002770	COG2875	Belongs to the precorrin methyltransferase family
K529_002785	COG2099	Precorrin-6x reductase
K529_002890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_002900	COG2268	Band 7 protein
K529_002920	COG0667	Aldo Keto reductase
K529_002930	COG3246	L-lysine catabolic process to acetate
K529_002935	COG3040	lipid binding
K529_002940	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_002940	COG0824	Thioesterase
K529_002980	COG1595	DNA-templated transcription, initiation
K529_002995	COG3706	GGDEF domain
K529_003020	COG3447	MASE1 domain protein
K529_003020	COG5001	Diguanylate cyclase
K529_003020	COG5002	protein histidine kinase activity
K529_003030	COG0243	molybdopterin cofactor binding
K529_003050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K529_003055	COG1494	fructose-1,6-bisphosphatase
K529_003080	COG1741	Belongs to the pirin family
K529_003085	COG2223	nitrite transmembrane transporter activity
K529_003095	COG1757	Na H antiporter
K529_003100	COG2423	ornithine cyclodeaminase activity
K529_003110	COG1396	sequence-specific DNA binding
K529_003150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K529_003165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_003175	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_003175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_003190	COG0358	DNA primase activity
K529_003195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K529_003215	COG0432	Pfam Uncharacterised protein family UPF0047
K529_003220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K529_003225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K529_003225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K529_003260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K529_003265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K529_003275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_003310	COG0564	pseudouridine synthase activity
K529_003325	COG1414	Transcriptional regulator
K529_003330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_003350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K529_003365	COG1522	sequence-specific DNA binding
K529_003375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K529_003380	COG0287	Prephenate dehydrogenase
K529_003395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K529_003425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_003435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K529_003440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K529_003445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K529_003450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K529_003455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K529_003480	COG0697	spore germination
K529_003505	COG2983	Belongs to the UPF0260 family
K529_003510	COG0196	riboflavin kinase activity
K529_003530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_003530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_003540	COG0251	oxidation-reduction process
K529_003545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_003555	COG4717	serine-type aminopeptidase activity
K529_003560	COG0420	3'-5' exonuclease activity
K529_003575	COG0583	DNA-binding transcription factor activity
K529_003590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K529_003595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K529_003600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K529_003605	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K529_003605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K529_003610	COG1832	CoA-binding protein
K529_003625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K529_003630	COG0140	phosphoribosyl-ATP diphosphatase activity
K529_003635	COG0107	imidazoleglycerol-phosphate synthase activity
K529_003650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K529_003675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K529_003690	COG0131	Imidazoleglycerol-phosphate dehydratase
K529_003700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_003730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K529_003750	COG0210	DNA helicase
K529_003770	COG0489	protein tyrosine kinase activity
K529_003780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K529_003785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K529_003790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K529_003805	COG0275	rRNA processing
K529_003810	COG2001	Belongs to the MraZ family
K529_003895	COG4397	Mu-like prophage major head subunit gpT
K529_003905	COG4388	Caudovirus prohead serine protease
K529_003920	COG2369	cell adhesion
K529_003935	COG4373	Mu-like prophage FluMu protein gp28
K529_004010	COG2801	Transposase and inactivated derivatives
K529_004110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K529_004125	COG1492	cobalamin metabolic process
K529_004135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K529_004145	COG0354	folic acid binding
K529_004150	COG1132	(ABC) transporter
K529_004155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K529_004165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K529_004170	COG1024	Enoyl-CoA hydratase
K529_004180	COG0840	transmembrane signaling receptor activity
K529_004185	COG3588	fructose-bisphosphate aldolase
K529_004200	COG0504	CTP synthase activity
K529_004225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K529_004255	COG1309	transcriptional regulator
K529_004260	COG1760	l-serine dehydratase
K529_004265	COG0625	glutathione transferase activity
K529_004270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K529_004300	COG0330	HflC and HflK could
K529_004305	COG3239	Fatty acid desaturase
K529_004350	COG1570	exodeoxyribonuclease VII activity
K529_004365	COG0552	protein localization to endoplasmic reticulum
K529_004370	COG1285	pathogenesis
K529_004400	COG1469	GTP cyclohydrolase I activity
K529_004410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_004415	COG0527	aspartate kinase activity
K529_004430	COG3293	Transposase
K529_004435	COG0028	Belongs to the TPP enzyme family
K529_004440	COG0625	glutathione transferase activity
K529_004450	COG3853	Toxic anion resistance protein (TelA)
K529_004460	COG1187	pseudouridine synthase activity
K529_004465	COG0590	tRNA wobble adenosine to inosine editing
K529_004475	COG1309	transcriptional regulator
K529_004485	COG2818	Glycosylase
K529_004490	COG0006	proline dipeptidase activity
K529_004495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K529_004505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K529_004510	COG0154	amidase activity
K529_004520	COG3023	N-Acetylmuramoyl-L-alanine amidase
K529_004530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K529_004540	COG0670	Belongs to the BI1 family
K529_004550	COG0583	DNA-binding transcription factor activity
K529_004555	COG0604	alcohol dehydrogenase
K529_004555	COG3321	synthase
K529_004560	COG1396	sequence-specific DNA binding
K529_004565	COG0483	inositol monophosphate 1-phosphatase activity
K529_004575	COG0402	S-adenosylhomocysteine deaminase activity
K529_004580	COG2239	Acts as a magnesium transporter
K529_004585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K529_004600	COG1692	metallophosphoesterase
K529_004605	COG0471	metal ion transport
K529_004605	COG3273	potassium ion transport
K529_004625	COG0471	metal ion transport
K529_004625	COG3273	potassium ion transport
K529_004635	COG0217	transcriptional regulatory protein
K529_004660	COG1741	Belongs to the pirin family
K529_004665	COG0488	(ABC) transporter
K529_004675	COG0697	spore germination
K529_004685	COG1309	transcriptional regulator
K529_004715	COG1396	sequence-specific DNA binding
K529_004715	COG3800	Transcriptional regulator
K529_004720	COG2814	Major facilitator Superfamily
K529_004725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K529_004760	COG4770	biotin carboxylase activity
K529_004780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_004780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_004800	COG1247	-acetyltransferase
K529_004835	COG0248	Ppx GppA phosphatase
K529_004850	COG0628	permease
K529_004860	COG0442	prolyl-tRNA aminoacylation
K529_004890	COG1136	(ABC) transporter
K529_004905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K529_004915	COG2079	MmgE PrpD family protein
K529_004925	COG1396	sequence-specific DNA binding
K529_004925	COG3800	Transcriptional regulator
K529_004930	COG0617	tRNA 3'-terminal CCA addition
K529_004930	COG0517	IMP dehydrogenase activity
K529_004930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K529_004960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K529_004965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_004970	COG0174	glutamine synthetase
K529_004975	COG0519	Catalyzes the synthesis of GMP from XMP
K529_004975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_004980	COG0174	glutamine synthetase
K529_005005	COG1278	Cold shock
K529_005025	COG1132	(ABC) transporter
K529_005035	COG0318	PFAM AMP-dependent synthetase and ligase
K529_005040	COG0657	acetylesterase activity
K529_005065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_005070	COG0601	transmembrane transport
K529_005080	COG1490	D-aminoacyl-tRNA deacylase activity
K529_005095	COG2124	cytochrome p450
K529_005105	COG2204	response regulator
K529_005110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_005115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_005120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_005125	COG0513	Belongs to the DEAD box helicase family
K529_005135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K529_005155	COG1028	Short-chain dehydrogenase reductase Sdr
K529_005160	COG4335	DNA alkylation repair
K529_005165	COG3842	ATPase activity
K529_005185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K529_005190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K529_005195	COG0805	protein transport
K529_005210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K529_005215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K529_005220	COG4221	oxidoreductase activity
K529_005265	COG1127	ABC transporter
K529_005270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K529_005275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K529_005285	COG3293	Transposase
K529_005295	COG0305	Participates in initiation and elongation during chromosome replication
K529_005300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K529_005305	COG0418	dihydroorotase activity
K529_005345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K529_005370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K529_005390	COG0175	sulfate reduction
K529_005395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K529_005405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K529_005405	COG1648	precorrin-2 dehydrogenase activity
K529_005410	COG1522	sequence-specific DNA binding
K529_005475	COG3609	addiction module antidote protein, CC2985 family
K529_005570	COG0004	ammonium transporteR
K529_005585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K529_005590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K529_005615	COG2267	carboxylic ester hydrolase activity
K529_005630	COG3739	integral membrane protein
K529_005650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K529_005660	COG0154	amidase activity
K529_005665	COG3237	CsbD-like
K529_005675	COG0280	phosphate acetyltransferase
K529_005675	COG0281	malic enzyme
K529_005685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K529_005690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K529_005695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K529_005720	COG1902	pentaerythritol trinitrate reductase activity
K529_005725	COG2814	Major facilitator Superfamily
K529_005730	COG1028	Short-chain dehydrogenase reductase Sdr
K529_005740	COG0583	DNA-binding transcription factor activity
K529_005745	COG0318	PFAM AMP-dependent synthetase and ligase
K529_005765	COG1024	Enoyl-CoA hydratase
K529_005765	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_005770	COG0183	Belongs to the thiolase family
K529_005775	COG0625	glutathione transferase activity
K529_005780	COG1960	acyl-CoA dehydrogenase activity
K529_005790	COG1960	acyl-CoA dehydrogenase activity
K529_005795	COG0789	Transcriptional regulator
K529_005820	COG0534	Mate efflux family protein
K529_005835	COG0737	Belongs to the 5'-nucleotidase family
K529_005855	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K529_005865	COG1320	monovalent cation:proton antiporter activity
K529_005870	COG2212	antiporter activity
K529_005875	COG1863	multisubunit Na H antiporter MnhE subunit
K529_005880	COG0651	ATP synthesis coupled electron transport
K529_005885	COG1006	Multisubunit Na H antiporter MnhC subunit
K529_005890	COG2111	Na H antiporter
K529_005890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K529_005905	COG2943	transferase activity, transferring hexosyl groups
K529_005910	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K529_005925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_005945	COG0740	serine-type endopeptidase activity
K529_005950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K529_005985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K529_005990	COG0439	Biotin carboxylase
K529_005995	COG0511	ligase activity, forming carbon-carbon bonds
K529_006005	COG0410	ABC transporter
K529_006030	COG3800	Transcriptional regulator
K529_006030	COG1396	sequence-specific DNA binding
K529_006070	COG3750	Belongs to the UPF0335 family
K529_006075	COG0493	'glutamate synthase
K529_006085	COG1309	transcriptional regulator
K529_006100	COG1116	anion transmembrane transporter activity
K529_006105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_006110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_006135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K529_006150	COG0840	transmembrane signaling receptor activity
K529_006160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_006175	COG0583	DNA-binding transcription factor activity
K529_006180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_006185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K529_006190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K529_006195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K529_006205	COG2166	iron-sulfur cluster assembly
K529_006215	COG5012	cobalamin binding
K529_006225	COG0646	methionine synthase
K529_006225	COG1410	methionine synthase
K529_006240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K529_006245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K529_006250	COG0047	phosphoribosylformylglycinamidine synthase activity
K529_006265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K529_006270	COG1530	ribonuclease E activity
K529_006275	COG0425	Belongs to the sulfur carrier protein TusA family
K529_006280	COG0785	Cytochrome C biogenesis protein
K529_006310	COG0114	fumarate hydratase activity
K529_006345	COG2188	Transcriptional regulator
K529_006360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_006365	COG0604	alcohol dehydrogenase
K529_006370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K529_006375	COG0415	Belongs to the DNA photolyase family
K529_006390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K529_006390	COG3264	Mechanosensitive ion channel
K529_006400	COG0483	inositol monophosphate 1-phosphatase activity
K529_006415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K529_006420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K529_006425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K529_006435	COG4974	Belongs to the 'phage' integrase family
K529_006440	COG4536	flavin adenine dinucleotide binding
K529_006450	COG0629	single-stranded DNA binding
K529_006455	COG0741	lytic transglycosylase activity
K529_006455	COG1196	nuclear chromosome segregation
K529_006455	COG0739	heme binding
K529_006465	COG1858	cytochrome C peroxidase
K529_006480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_006485	COG0601	transmembrane transport
K529_006500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K529_006505	COG0528	UMP kinase activity
K529_006510	COG0233	cytoplasmic translational termination
K529_006515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K529_006525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K529_006530	COG0750	zinc metalloprotease
K529_006535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_006545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K529_006550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_006560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_006565	COG0482	sulfurtransferase activity
K529_006575	COG0745	RESPONSE REGULATOR receiver
K529_006580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K529_006585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K529_006595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K529_006600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_006605	COG2264	protein methyltransferase activity
K529_006610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K529_006620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K529_006625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K529_006635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_006640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K529_006645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K529_006650	COG0840	transmembrane signaling receptor activity
K529_006655	COG1309	transcriptional regulator
K529_006660	COG2326	polyphosphate kinase activity
K529_006670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K529_006695	COG0519	Catalyzes the synthesis of GMP from XMP
K529_006695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_006715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K529_006720	COG1473	amidohydrolase
K529_006730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K529_006735	COG2867	negative regulation of translational initiation
K529_006740	COG1546	Belongs to the CinA family
K529_006745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K529_006750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K529_006750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K529_006755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K529_006760	COG3852	Histidine kinase
K529_006765	COG2204	response regulator
K529_006770	COG5000	phosphorelay sensor kinase activity
K529_006775	COG2204	response regulator
K529_006780	COG0569	domain protein
K529_006785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_006790	COG1923	regulation of RNA biosynthetic process
K529_006795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K529_006805	COG2084	Dehydrogenase
K529_006825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K529_006830	COG2814	Major facilitator Superfamily
K529_006855	COG4166	transmembrane transport
K529_006860	COG1028	Short-chain dehydrogenase reductase Sdr
K529_006875	COG2313	pseudouridylate synthase activity
K529_006895	COG1612	heme a metabolic process
K529_006900	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K529_006910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K529_006915	COG5425	PFAM Usg family protein
K529_006920	COG0363	glucosamine-6-phosphate deaminase activity
K529_006985	COG2133	pyrroloquinoline quinone binding
K529_006995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K529_007005	COG1561	YicC-like family, N-terminal region
K529_007010	COG0194	GDP metabolic process
K529_007020	COG0626	cystathionine gamma-synthase activity
K529_007025	COG5002	protein histidine kinase activity
K529_007035	COG0573	inorganic phosphate transmembrane transporter activity
K529_007045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_007050	COG0704	Plays a role in the regulation of phosphate uptake
K529_007055	COG0745	RESPONSE REGULATOR receiver
K529_007060	COG0583	DNA-binding transcription factor activity
K529_007065	COG1960	acyl-CoA dehydrogenase activity
K529_007070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_007080	COG2358	TRAP transporter, solute receptor (TAXI family
K529_007125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K529_007140	COG0719	Fe-S assembly protein
K529_007145	COG0396	ATPase activity
K529_007155	COG0393	Putative heavy-metal-binding
K529_007160	COG0719	Fe-S assembly protein
K529_007170	COG1959	2 iron, 2 sulfur cluster binding
K529_007175	COG2945	thiolester hydrolase activity
K529_007190	COG2076	Multidrug Resistance protein
K529_007195	COG1217	gtp-binding protein TYPA
K529_007200	COG0121	glutamine amidotransferase
K529_007210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K529_007220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K529_007235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K529_007235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K529_007245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_007250	COG0516	GMP reductase activity
K529_007250	COG0517	IMP dehydrogenase activity
K529_007255	COG0433	COG0433 Predicted ATPase
K529_007275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_007280	COG0793	Belongs to the peptidase S41A family
K529_007285	COG3108	Peptidase M15
K529_007305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K529_007310	COG2197	response regulator
K529_007315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K529_007320	COG0052	Belongs to the universal ribosomal protein uS2 family
K529_007345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K529_007350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K529_007355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K529_007365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K529_007370	COG3743	rRNA binding
K529_007370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K529_007395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K529_007405	COG0248	Ppx GppA phosphatase
K529_007410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K529_007435	COG0577	efflux transmembrane transporter activity
K529_007450	COG1653	transport
K529_007460	COG0395	ABC-type sugar transport system, permease component
K529_007465	COG3842	ATPase activity
K529_007470	COG0840	transmembrane signaling receptor activity
K529_007535	COG1238	metal cluster binding
K529_007550	COG0010	Belongs to the arginase family
K529_007595	COG2814	Major facilitator Superfamily
K529_007605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_007610	COG0215	cysteine-tRNA ligase activity
K529_007620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_007640	COG0259	pyridoxamine-phosphate oxidase activity
K529_007645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K529_007650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K529_007665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K529_007680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K529_007685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K529_007705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K529_007710	COG0658	competence protein
K529_007710	COG2333	competence protein COMEC
K529_007715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_007720	COG0372	Belongs to the citrate synthase family
K529_007730	COG1024	Enoyl-CoA hydratase
K529_007740	COG3088	subunit of a heme lyase
K529_007745	COG1138	Cytochrome C-type biogenesis protein
K529_007760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K529_007765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K529_007770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K529_007790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K529_007810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K529_007825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K529_007830	COG2354	Protein conserved in bacteria
K529_007840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K529_007900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K529_007910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_007930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K529_007940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K529_007945	COG2833	Protein of unknown function (DUF455)
K529_007950	COG0739	heme binding
K529_007975	COG0126	phosphoglycerate kinase activity
K529_007990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K529_007995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_008000	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_008000	COG0022	dehydrogenase e1 component
K529_008005	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_008015	COG1278	Cold shock
K529_008095	COG4695	Portal protein
K529_008110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K529_008115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K529_008120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K529_008125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K529_008135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K529_008140	COG3038	cytochrome b561
K529_008155	COG2353	YceI-like domain
K529_008165	COG0360	Binds together with S18 to 16S ribosomal RNA
K529_008170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K529_008175	COG0359	binds to the 23S rRNA
K529_008180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_008185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_008190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_008205	COG0737	Belongs to the 5'-nucleotidase family
K529_008210	COG3706	GGDEF domain
K529_008215	COG0544	peptidyl-prolyl cis-trans isomerase activity
K529_008225	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K529_008230	COG4251	negative regulation of phosphorylation
K529_008245	COG0840	transmembrane signaling receptor activity
K529_008250	COG1049	propionate catabolic process, 2-methylcitrate cycle
K529_008260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K529_008275	COG0443	Heat shock 70 kDa protein
K529_008295	COG0006	proline dipeptidase activity
K529_008320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K529_008360	COG1028	Short-chain dehydrogenase reductase Sdr
K529_008365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_008375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K529_008380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K529_008385	COG4133	protoheme IX ABC transporter activity
K529_008390	COG3737	Protein of unknown function (DUF498/DUF598)
K529_008395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K529_008400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K529_008405	COG1862	Preprotein translocase
K529_008410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K529_008420	COG3239	Fatty acid desaturase
K529_008425	COG2095	MarC family integral membrane protein
K529_008430	COG1160	GTP binding
K529_008435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_008450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_008465	COG0840	transmembrane signaling receptor activity
K529_008490	COG5265	(ABC) transporter
K529_008540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_008540	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_008555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_008560	COG4235	cytochrome complex assembly
K529_008565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K529_008580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K529_008585	COG5002	protein histidine kinase activity
K529_008585	COG2198	Histidine kinase
K529_008585	COG0784	Response regulator, receiver
K529_008610	COG0105	UTP biosynthetic process
K529_008615	COG2814	Major facilitator Superfamily
K529_008625	COG0488	(ABC) transporter
K529_008630	COG2095	MarC family integral membrane protein
K529_008645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K529_008665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K529_008670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K529_008675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K529_008685	COG2890	protein-(glutamine-N5) methyltransferase activity
K529_008690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K529_008705	COG0010	Belongs to the arginase family
K529_008710	COG1473	amidohydrolase
K529_008715	COG3956	TIGRFAM MazG family protein
K529_008720	COG1957	nucleoside hydrolase
K529_008725	COG0456	acetyltransferase
K529_008735	COG0148	phosphopyruvate hydratase activity
K529_008745	COG0697	spore germination
K529_008760	COG0513	Belongs to the DEAD box helicase family
K529_008765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K529_008775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K529_008780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K529_008795	COG0488	(ABC) transporter
K529_008815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K529_008820	COG0416	fatty acid biosynthetic process
K529_008825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K529_008830	COG0776	regulation of translation
K529_008845	COG0717	Belongs to the dCTP deaminase family
K529_008855	COG2814	Major facilitator Superfamily
K529_008865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K529_008870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K529_008875	COG1472	Belongs to the glycosyl hydrolase 3 family
K529_008885	COG0018	arginyl-trna synthetase
K529_008890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K529_008895	COG0316	Belongs to the HesB IscA family
K529_008920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_008960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K529_008970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K529_008980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K529_008995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K529_009000	COG0346	lactoylglutathione lyase activity
K529_009005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_009030	COG0028	Belongs to the TPP enzyme family
K529_009035	COG0440	acetolactate synthase activity
K529_009060	COG1280	lysine exporter protein (LysE YggA)
K529_009070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K529_009075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K529_009085	COG0860	N-Acetylmuramoyl-L-alanine amidase
K529_009090	COG0436	Aminotransferase
K529_009100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_009100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_009105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K529_009110	COG1426	Protein conserved in bacteria
K529_009115	COG0156	8-amino-7-oxononanoate synthase activity
K529_009125	COG1607	acyl-coa hydrolase
K529_009150	COG5507	3-demethylubiquinone-9 3-methyltransferase
K529_009155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K529_009160	COG0602	queuosine metabolic process
K529_009165	COG0720	synthase
K529_009170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K529_009185	COG0406	alpha-ribazole phosphatase activity
K529_009190	COG1283	sodium-dependent phosphate transmembrane transporter activity
K529_009200	COG0584	glycerophosphoryl diester phosphodiesterase
K529_009205	COG3842	ATPase activity
K529_009210	COG0395	ABC-type sugar transport system, permease component
K529_009220	COG1653	transport
K529_009225	COG0583	DNA-binding transcription factor activity
K529_009230	COG3842	ATPase activity
K529_009235	COG1177	transmembrane transport
K529_009250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_009255	COG2267	carboxylic ester hydrolase activity
K529_009265	COG2197	response regulator
K529_009275	COG0583	DNA-binding transcription factor activity
K529_009290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_009305	COG2197	response regulator
K529_009335	COG4948	Mandelate Racemase Muconate Lactonizing
K529_009345	COG0583	DNA-binding transcription factor activity
K529_009375	COG2188	Transcriptional regulator
K529_009390	COG2267	carboxylic ester hydrolase activity
K529_009395	COG0840	transmembrane signaling receptor activity
K529_009400	COG3842	ATPase activity
K529_009410	COG1177	transmembrane transport
K529_009420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K529_009435	COG0840	transmembrane signaling receptor activity
K529_009445	COG0776	regulation of translation
K529_009455	COG1902	pentaerythritol trinitrate reductase activity
K529_009470	COG0343	queuine tRNA-ribosyltransferase activity
K529_009475	COG0189	ligase activity
K529_009475	COG4067	protein conserved in archaea
K529_009495	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_009500	COG0316	Belongs to the HesB IscA family
K529_009505	COG0149	triose-phosphate isomerase activity
K529_009520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K529_009530	COG1007	ATP synthesis coupled electron transport
K529_009545	COG0713	ATP synthesis coupled electron transport
K529_009560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_009565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K529_009615	COG0649	NAD binding
K529_009620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_009625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_009635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K529_009645	COG4770	biotin carboxylase activity
K529_009650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K529_009660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K529_009665	COG3047	cAMP biosynthetic process
K529_009675	COG1960	acyl-CoA dehydrogenase activity
K529_009695	COG0546	phosphoglycolate phosphatase activity
K529_009700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K529_009720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K529_009725	COG1519	Transferase
K529_009730	COG0438	transferase activity, transferring glycosyl groups
K529_009750	COG1473	amidohydrolase
K529_009755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_009760	COG4172	Belongs to the ABC transporter superfamily
K529_009770	COG0601	transmembrane transport
K529_009775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_009785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K529_009790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K529_009800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K529_009810	COG0308	aminopeptidase N
K529_009825	COG2183	response to ionizing radiation
K529_009830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K529_009840	COG1739	Uncharacterized protein family UPF0029
K529_009855	COG1872	DUF167
K529_009860	COG0778	Nitroreductase
K529_009880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_009890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K529_009895	COG0849	cell division
K529_009900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K529_009905	COG1181	Belongs to the D-alanine--D-alanine ligase family
K529_009910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K529_009930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K529_009935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K529_009945	COG2081	HI0933 family
K529_009950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K529_009955	COG0481	GTPase activity
K529_009965	COG0583	DNA-binding transcription factor activity
K529_009970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K529_009975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K529_009990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K529_009995	COG1703	isobutyryl-CoA mutase activity
K529_010005	COG1643	Atp-dependent helicase
K529_010015	COG0306	phosphate transporter
K529_010025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K529_010030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K529_010040	COG0842	Transport permease protein
K529_010065	COG1280	lysine exporter protein (LysE YggA)
K529_010085	COG0625	glutathione transferase activity
K529_010095	COG1573	uracil-dna glycosylase
K529_010110	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K529_010125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_010130	COG2195	Cleaves the N-terminal amino acid of tripeptides
K529_010165	COG0006	proline dipeptidase activity
K529_010175	COG0583	DNA-binding transcription factor activity
K529_010200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K529_010210	COG0512	Glutamine amidotransferase of anthranilate synthase
K529_010210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K529_010215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K529_010240	COG0431	NADPH-dependent FMN reductase
K529_010250	COG1435	thymidine kinase activity
K529_010260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_010280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K529_010290	COG1496	oxidoreductase activity
K529_010300	COG1522	sequence-specific DNA binding
K529_010305	COG0492	ferredoxin-NADP+ reductase activity
K529_010315	COG0529	Catalyzes the synthesis of activated sulfate
K529_010315	COG2046	Belongs to the sulfate adenylyltransferase family
K529_010325	COG0071	Belongs to the small heat shock protein (HSP20) family
K529_010335	COG0306	phosphate transporter
K529_010350	COG0384	phenazine biosynthesis protein PhzF
K529_010355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K529_010360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K529_010365	COG3454	Phosphonate metabolism
K529_010385	COG0459	protein refolding
K529_010390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K529_010415	COG1227	inorganic diphosphatase activity
K529_010435	COG1846	Transcriptional regulator
K529_010450	COG2030	dehydratase
K529_010465	COG2873	o-acetylhomoserine
K529_010495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K529_010495	COG0475	glutathione-regulated potassium exporter activity
K529_010500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K529_010505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K529_010510	COG1329	Transcriptional regulator
K529_010515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K529_010555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K529_010580	COG0583	DNA-binding transcription factor activity
K529_010590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K529_010595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_010600	COG3485	protocatechuate 3,4-dioxygenase
K529_010605	COG3485	protocatechuate 3,4-dioxygenase
K529_010610	COG3246	L-lysine catabolic process to acetate
K529_010625	COG1595	DNA-templated transcription, initiation
K529_010635	COG0527	aspartate kinase activity
K529_010640	COG1917	Cupin 2, conserved barrel domain protein
K529_010645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_010685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_010690	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_010700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K529_010705	COG0588	phosphoglycerate mutase activity
K529_010725	COG0631	protein serine/threonine phosphatase activity
K529_010815	COG0739	heme binding
K529_010840	COG0811	peptide transport
K529_010880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K529_010885	COG2719	SpoVR family
K529_010890	COG2718	Belongs to the UPF0229 family
K529_010895	COG2766	serine protein kinase
K529_010910	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
K529_010915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_010920	COG3591	Belongs to the peptidase S1B family
K529_010930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K529_010940	COG0798	PFAM Bile acid sodium symporter
K529_010955	COG1780	Probably involved in ribonucleotide reductase function
K529_010960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_010965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_010985	COG1012	belongs to the aldehyde dehydrogenase family
K529_010995	COG0583	DNA-binding transcription factor activity
K529_011000	COG1473	amidohydrolase
K529_011035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K529_011040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K529_011045	COG0124	histidyl-tRNA synthetase
K529_011065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K529_011070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K529_011075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K529_011095	COG0612	Peptidase, M16
K529_011105	COG3346	SURF1 family
K529_011115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K529_011125	COG0109	protoheme IX farnesyltransferase activity
K529_011135	COG0312	modulator of DNA gyrase
K529_011140	COG0758	DNA mediated transformation
K529_011140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K529_011145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K529_011145	COG1754	DNA topoisomerase type I activity
K529_011150	COG1309	transcriptional regulator
K529_011190	COG4964	Belongs to the GSP D family
K529_011195	COG2885	chlorophyll binding
K529_011245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K529_011255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K529_011270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K529_011275	COG0037	tRNA processing
K529_011285	COG2885	chlorophyll binding
K529_011290	COG0823	Involved in the tonB-independent uptake of proteins
K529_011310	COG0824	Thioesterase
K529_011325	COG2255	four-way junction helicase activity
K529_011330	COG0632	four-way junction helicase activity
K529_011335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K529_011350	COG2264	protein methyltransferase activity
K529_011365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K529_011380	COG1183	phosphatidylcholine synthase activity
K529_011390	COG0101	tRNA pseudouridine synthase activity
K529_011395	COG3106	COG3106 Predicted ATPase
K529_011405	COG3768	UPF0283 membrane protein
K529_011420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K529_011435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K529_011435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K529_011440	COG0509	glycine decarboxylation via glycine cleavage system
K529_011445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_011555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K529_011555	COG0116	Belongs to the methyltransferase superfamily
K529_011565	COG3842	ATPase activity
K529_011570	COG3842	ATPase activity
K529_011575	COG1175	transmembrane transport
K529_011580	COG0395	ABC-type sugar transport system, permease component
K529_011635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K529_011645	COG1660	Displays ATPase and GTPase activities
K529_011655	COG2205	protein histidine kinase activity
K529_011660	COG0745	RESPONSE REGULATOR receiver
K529_011665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K529_011685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K529_011705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K529_011710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K529_011715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_011720	COG0840	transmembrane signaling receptor activity
K529_011725	COG1846	Transcriptional regulator
K529_011730	COG0697	spore germination
K529_011740	COG1051	belongs to the nudix hydrolase family
K529_011745	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_011745	COG1902	pentaerythritol trinitrate reductase activity
K529_011750	COG2070	2-Nitropropane dioxygenase
K529_011755	COG0583	DNA-binding transcription factor activity
K529_011770	COG1280	lysine exporter protein (LysE YggA)
K529_011790	COG1058	Belongs to the CinA family
K529_011790	COG1546	Belongs to the CinA family
K529_011795	COG1489	DNA binding
K529_011800	COG0668	transmembrane transport
K529_011805	COG0024	Methionine aminopeptidase
K529_011810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K529_011815	COG0742	ribosomal rna small subunit methyltransferase
K529_011825	COG0678	peroxiredoxin activity
K529_011835	COG2154	pterin-4-alpha-carbinolamine dehydratase
K529_011875	COG1476	TRANSCRIPTIONal
K529_011885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K529_011890	COG0697	spore germination
K529_011895	COG1396	sequence-specific DNA binding
K529_011900	COG3135	benzoate transporter
K529_011905	COG0129	dihydroxy-acid dehydratase activity
K529_011950	COG0697	spore germination
K529_011960	COG0071	Belongs to the small heat shock protein (HSP20) family
K529_011965	COG3591	Belongs to the peptidase S1B family
K529_011970	COG0247	lactate metabolic process
K529_011980	COG0277	FAD linked oxidase domain protein
K529_011985	COG0277	FAD linked oxidase domain protein
K529_012000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K529_012005	COG0799	negative regulation of ribosome biogenesis
K529_012010	COG3264	Mechanosensitive ion channel
K529_012010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K529_012015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K529_012020	COG0066	3-isopropylmalate dehydratase activity
K529_012025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K529_012035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K529_012040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K529_012050	COG0469	pyruvate kinase activity
K529_012075	COG0322	excinuclease ABC activity
K529_012080	COG1028	Short-chain dehydrogenase reductase Sdr
K529_012095	COG0842	Transport permease protein
K529_012100	COG1131	(ABC) transporter
K529_012110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_012115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K529_012120	COG0181	hydroxymethylbilane synthase activity
K529_012135	COG0408	coproporphyrinogen oxidase activity
K529_012140	COG1028	Short-chain dehydrogenase reductase Sdr
K529_012145	COG2813	Specifically methylates the guanine in position
K529_012150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K529_012160	COG1686	Belongs to the peptidase S11 family
K529_012180	COG0348	domain, Protein
K529_012185	COG0583	DNA-binding transcription factor activity
K529_012195	COG2010	Cytochrome c
K529_012225	COG3293	Transposase
K529_012230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K529_012235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_012240	COG4172	Belongs to the ABC transporter superfamily
K529_012245	COG4239	(ABC) transporter, permease
K529_012250	COG4174	ABC transporter (Permease)
K529_012265	COG1605	Chorismate mutase
K529_012265	COG0077	Prephenate dehydratase
K529_012275	COG1381	Involved in DNA repair and RecF pathway recombination
K529_012285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K529_012290	COG0571	ribonuclease III activity
K529_012295	COG0681	Belongs to the peptidase S26 family
K529_012300	COG0736	holo-[acyl-carrier-protein] synthase activity
K529_012310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K529_012320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K529_012325	COG1758	RNA polymerase activity
K529_012330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K529_012340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K529_012360	COG0328	RNA-DNA hybrid ribonuclease activity
K529_012365	COG2860	membrane
K529_012380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K529_012385	COG0242	peptide deformylase activity
K529_012390	COG0242	peptide deformylase activity
K529_012400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K529_012410	COG0435	Glutathione S-transferase
K529_012420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K529_012425	COG3773	Cell wall hydrolase
K529_012425	COG3409	Peptidoglycan-binding domain 1 protein
K529_012435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_012445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_012450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K529_012455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K529_012460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K529_012465	COG0356	it plays a direct role in the translocation of protons across the membrane
K529_012495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K529_012510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K529_012530	COG0228	four-way junction DNA binding
K529_012535	COG0778	Nitroreductase
K529_012540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K529_012550	COG0336	Belongs to the RNA methyltransferase TrmD family
K529_012570	COG2814	Major facilitator Superfamily
K529_012575	COG0335	large ribosomal subunit rRNA binding
K529_012580	COG0254	rRNA binding
K529_012585	COG0489	protein tyrosine kinase activity
K529_012585	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_012600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K529_012605	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_012625	COG0625	glutathione transferase activity
K529_012630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K529_012635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K529_012640	COG0347	Belongs to the P(II) protein family
K529_012645	COG0004	ammonium transporteR
K529_012665	COG2897	thiosulfate sulfurtransferase activity
K529_012675	COG3622	Belongs to the hyi family
K529_012680	COG0673	inositol 2-dehydrogenase activity
K529_012695	COG1879	ABC-type sugar transport system periplasmic component
K529_012710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_012715	COG3962	Belongs to the TPP enzyme family
K529_012725	COG3718	enzyme involved in inositol metabolism
K529_012735	COG1177	transmembrane transport
K529_012745	COG3842	ATPase activity
K529_012775	COG0312	modulator of DNA gyrase
K529_012780	COG0483	inositol monophosphate 1-phosphatase activity
K529_012790	COG1663	tetraacyldisaccharide 4'-kinase activity
K529_012805	COG1194	a g-specific adenine glycosylase
K529_012815	COG0840	transmembrane signaling receptor activity
K529_012830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K529_012855	COG1012	belongs to the aldehyde dehydrogenase family
K529_012865	COG1522	sequence-specific DNA binding
K529_012870	COG3022	response to hydroperoxide
K529_012875	COG0514	ATP-dependent DNA helicase (RecQ)
K529_012895	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K529_012915	COG3191	aminopeptidase activity
K529_012920	COG0697	spore germination
K529_012930	COG2423	ornithine cyclodeaminase activity
K529_012935	COG2267	carboxylic ester hydrolase activity
K529_012945	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K529_012960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K529_012970	COG1132	(ABC) transporter
K529_012990	COG2169	Transcriptional regulator
K529_012990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K529_013040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K529_013050	COG3119	arylsulfatase activity
K529_013095	COG4608	Belongs to the ABC transporter superfamily
K529_013100	COG0444	Belongs to the ABC transporter superfamily
K529_013110	COG0747	negative chemotaxis
K529_013135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_013140	COG1012	belongs to the aldehyde dehydrogenase family
K529_013145	COG1522	sequence-specific DNA binding
K529_013150	COG3608	succinylglutamate desuccinylase aspartoacylase
K529_013155	COG4977	sequence-specific DNA binding
K529_013165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_013170	COG1120	ATPase activity
K529_013190	COG1414	Transcriptional regulator
K529_013195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K529_013200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_013205	COG3616	Alanine racemase, N-terminal domain
K529_013210	COG2423	ornithine cyclodeaminase activity
K529_013225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_013240	COG1522	sequence-specific DNA binding
K529_013245	COG0133	tryptophan synthase activity
K529_013250	COG0006	proline dipeptidase activity
K529_013260	COG0006	proline dipeptidase activity
K529_013265	COG0747	negative chemotaxis
K529_013275	COG0601	transmembrane transport
K529_013280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_013285	COG0444	Belongs to the ABC transporter superfamily
K529_013305	COG0784	Response regulator, receiver
K529_013355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_013380	COG5002	protein histidine kinase activity
K529_013390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K529_013400	COG1522	sequence-specific DNA binding
K529_013410	COG0456	acetyltransferase
K529_013420	COG0444	Belongs to the ABC transporter superfamily
K529_013425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_013430	COG0601	transmembrane transport
K529_013460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_013475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_013480	COG0251	oxidation-reduction process
K529_013485	COG0793	Belongs to the peptidase S41A family
K529_013495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K529_013510	COG1280	lysine exporter protein (LysE YggA)
K529_013520	COG1131	(ABC) transporter
K529_013530	COG0655	NAD(P)H dehydrogenase (quinone) activity
K529_013540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K529_013540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K529_013550	COG3622	Belongs to the hyi family
K529_013560	COG0714	Associated with various cellular activities
K529_013585	COG4953	penicillin-binding protein 1C
K529_013590	COG2373	Large extracellular alpha-helical protein
K529_013595	COG0784	Response regulator, receiver
K529_013595	COG5002	protein histidine kinase activity
K529_013595	COG2205	protein histidine kinase activity
K529_013600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_013610	COG0022	dehydrogenase e1 component
K529_013625	COG1522	sequence-specific DNA binding
K529_013640	COG0174	glutamine synthetase
K529_013675	COG0318	PFAM AMP-dependent synthetase and ligase
K529_013680	COG0183	Belongs to the thiolase family
K529_013685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K529_013710	COG1960	acyl-CoA dehydrogenase activity
K529_013730	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K529_013735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K529_013740	COG0776	regulation of translation
K529_013750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_013755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_013765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K529_013775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K529_013790	COG1968	undecaprenyl-diphosphatase activity
K529_013810	COG1733	regulation of RNA biosynthetic process
K529_013820	COG0840	transmembrane signaling receptor activity
K529_013825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K529_013830	COG4143	(ABC) transporter
K529_013840	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K529_013865	COG3896	Chloramphenicol phosphotransferase-like protein
K529_013870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_013875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K529_013945	COG0840	transmembrane signaling receptor activity
K529_014020	COG0717	Belongs to the dCTP deaminase family
K529_014060	COG3293	Transposase
K529_014085	COG0653	protein targeting
K529_014105	COG0582	viral genome integration into host DNA
K529_014135	COG3727	T/G mismatch-specific endonuclease activity
K529_014210	COG1278	Cold shock
K529_014325	COG3772	lysozyme
K529_014345	COG1012	belongs to the aldehyde dehydrogenase family
K529_014370	COG4948	Mandelate Racemase Muconate Lactonizing
K529_014375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_014385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_014385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_014405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K529_014410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K529_014435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K529_014445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K529_014455	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K529_014460	COG1999	signal sequence binding
K529_014470	COG2205	protein histidine kinase activity
K529_014475	COG0802	atpase or kinase
K529_014480	COG3178	'Phosphotransferase
K529_014485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K529_014495	COG1074	ATP-dependent DNA helicase activity
K529_014510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K529_014520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K529_014545	COG3030	protein affecting phage T7 exclusion by the F plasmid
K529_014550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K529_014560	COG0237	dephospho-CoA kinase activity
K529_014565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K529_014570	COG0424	maF-like protein
K529_014575	COG1981	membrane
K529_014580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K529_014585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K529_014590	COG0445	tRNA wobble uridine modification
K529_014595	COG0357	Ribosomal RNA small subunit methyltransferase G
K529_014610	COG2832	Protein of unknown function (DUF454)
K529_014615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_014620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K529_014625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K529_014635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K529_014640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K529_014645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_014650	COG0281	malic enzyme
K529_014650	COG0280	phosphate acetyltransferase
K529_014660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_014680	COG0137	argininosuccinate synthase activity
K529_014690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_014700	COG0745	RESPONSE REGULATOR receiver
K529_014705	COG0494	nUDIX hydrolase
K529_014720	COG0617	tRNA 3'-terminal CCA addition
K529_014725	COG1132	(ABC) transporter
K529_014730	COG1132	(ABC) transporter
K529_014735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K529_014745	COG3034	peptidoglycan biosynthetic process
K529_014775	COG1040	competence protein
K529_014785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_014795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K529_014810	COG0779	Required for maturation of 30S ribosomal subunits
K529_014825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K529_014830	COG0494	nUDIX hydrolase
K529_014835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K529_014840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K529_014845	COG0653	protein targeting
K529_014870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_014875	COG0142	geranyltranstransferase activity
K529_014880	COG1722	exodeoxyribonuclease VII activity
K529_014885	COG0123	including yeast histone deacetylase and acetoin utilization protein
K529_014895	COG0745	RESPONSE REGULATOR receiver
K529_014900	COG1846	Transcriptional regulator
K529_014905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K529_014910	COG1764	response to oxidative stress
K529_014915	COG1846	Transcriptional regulator
K529_014930	COG0789	Transcriptional regulator
K529_014945	COG4607	ABC-type enterochelin transport system periplasmic component
K529_014950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_014955	COG4605	iron ion homeostasis
K529_014960	COG4604	ABC transporter, ATP-binding protein
K529_014975	COG4139	cobalamin transport
K529_014980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K529_014985	COG0840	transmembrane signaling receptor activity
K529_014990	COG1360	Flagellar Motor Protein
K529_015010	COG1706	bacterial-type flagellum-dependent cell motility
K529_015015	COG1338	Plays a role in the flagellum-specific transport system
K529_015020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K529_015030	COG1766	The M ring may be actively involved in energy transduction
K529_015050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K529_015060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K529_015065	COG1684	flagellar biosynthetic protein fliR
K529_015070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K529_015085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K529_015095	COG4786	Flagellar basal body rod
K529_015100	COG4786	Flagellar basal body rod
K529_015105	COG1987	bacterial-type flagellum assembly
K529_015110	COG1677	Flagellar hook-basal body complex protein FliE
K529_015115	COG1558	bacterial-type flagellum-dependent cell motility
K529_015120	COG1815	bacterial-type flagellum-dependent cell motility
K529_015135	COG5443	negative regulation of bacterial-type flagellum assembly
K529_015145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_015165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K529_015175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_015180	COG1177	transmembrane transport
K529_015185	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_015190	COG3842	ATPase activity
K529_015200	COG1802	Transcriptional regulator
K529_015210	COG3842	ATPase activity
K529_015220	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_015230	COG2951	lytic endotransglycosylase activity
K529_015235	COG2378	regulation of single-species biofilm formation
K529_015245	COG0557	exoribonuclease II activity
K529_015255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_015265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_015295	COG1228	amidohydrolase
K529_015300	COG2986	histidine ammonia-lyase
K529_015310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K529_015320	COG2171	N-acyltransferase activity
K529_015330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_015345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K529_015365	COG0560	Phosphoserine phosphatase
K529_015365	COG3830	Belongs to the UPF0237 family
K529_015370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K529_015375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K529_015380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K529_015385	COG1063	alcohol dehydrogenase
K529_015390	COG0156	8-amino-7-oxononanoate synthase activity
K529_015395	COG1396	sequence-specific DNA binding
K529_015400	COG0183	Belongs to the thiolase family
K529_015410	COG2226	methyltransferase
K529_015415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K529_015420	COG1024	Enoyl-CoA hydratase
K529_015425	COG0268	Binds directly to 16S ribosomal RNA
K529_015560	COG0583	DNA-binding transcription factor activity
K529_015565	COG0483	inositol monophosphate 1-phosphatase activity
K529_015580	COG1522	sequence-specific DNA binding
K529_015590	COG0628	permease
K529_015605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_015610	COG0028	Belongs to the TPP enzyme family
K529_015620	COG1802	Transcriptional regulator
K529_015625	COG0747	negative chemotaxis
K529_015630	COG0601	transmembrane transport
K529_015635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_015645	COG1609	Transcriptional regulator
K529_015655	COG1129	ABC transporter
K529_015660	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_015665	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_015675	COG1072	(Pantothenic acid kinase))
K529_015685	COG1294	oxidase, subunit
K529_015690	COG1271	oxidase subunit
K529_015770	COG0582	viral genome integration into host DNA
K529_015800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_015810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_015815	COG1917	Cupin 2, conserved barrel domain protein
K529_015825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_015830	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
K529_015845	COG0351	phosphomethylpyrimidine kinase
K529_015860	COG2022	thiamine diphosphate biosynthetic process
K529_015870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K529_015875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K529_015880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K529_015885	COG1116	anion transmembrane transporter activity
K529_015890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_015900	COG1473	amidohydrolase
K529_015905	COG4172	Belongs to the ABC transporter superfamily
K529_015910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_015915	COG0601	transmembrane transport
K529_015920	COG0747	negative chemotaxis
K529_015935	COG1268	BioY protein
K529_015945	COG1122	ATPase activity
K529_015950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K529_015955	COG4149	molybdate abc transporter
K529_015960	COG0725	ABC transporter, periplasmic molybdate-binding protein
K529_015965	COG1177	transmembrane transport
K529_015970	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_015975	COG3842	ATPase activity
K529_015980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_016025	COG3932	Exopolysaccharide synthesis, ExoD
K529_016055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_016060	COG0601	transmembrane transport
K529_016065	COG4166	transmembrane transport
K529_016070	COG3386	PFAM SMP-30 Gluconolaconase
K529_016075	COG0800	Aldolase
K529_016080	COG3734	2-keto-3-deoxy-galactonokinase
K529_016100	COG0129	dihydroxy-acid dehydratase activity
K529_016105	COG4214	carbohydrate transport
K529_016125	COG3293	Transposase
K529_016195	COG0697	spore germination
K529_016200	COG0473	3-isopropylmalate dehydrogenase activity
K529_016220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_016235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_016255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K529_016260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_016265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_016270	COG1120	ATPase activity
K529_016280	COG0811	peptide transport
K529_016285	COG0848	biopolymer transport protein
K529_016310	COG1126	abc transporter atp-binding protein
K529_016320	COG1595	DNA-templated transcription, initiation
K529_016340	COG0626	cystathionine gamma-synthase activity
K529_016360	COG0583	DNA-binding transcription factor activity
K529_016365	COG4774	siderophore transport
K529_016375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_016380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_016405	COG3293	Transposase
K529_016490	COG2188	Transcriptional regulator
K529_016495	COG0583	DNA-binding transcription factor activity
K529_016505	COG1028	Short-chain dehydrogenase reductase Sdr
K529_016510	COG2814	Major facilitator Superfamily
K529_016515	COG1902	pentaerythritol trinitrate reductase activity
K529_016535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_016545	COG0583	DNA-binding transcription factor activity
K529_016550	COG1881	PFAM PEBP family protein
K529_016565	COG2207	Transcriptional regulator
K529_016570	COG1129	ABC transporter
K529_016575	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_016590	COG0579	oxidoreductase
K529_016620	COG3842	ATPase activity
K529_016630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_016635	COG3958	Transketolase
K529_016640	COG1802	Transcriptional regulator
K529_016645	COG1028	Short-chain dehydrogenase reductase Sdr
K529_016660	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_016695	COG1942	4-Oxalocrotonate Tautomerase
K529_016705	COG0625	glutathione transferase activity
K529_016710	COG0583	DNA-binding transcription factor activity
K529_016720	COG0604	alcohol dehydrogenase
K529_016735	COG0583	DNA-binding transcription factor activity
K529_016790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_016805	COG0330	HflC and HflK could
K529_016850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K529_016895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_016900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_016935	COG2951	lytic endotransglycosylase activity
K529_016940	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_016945	COG1047	Peptidyl-prolyl cis-trans
K529_016965	COG0596	Alpha beta hydrolase
K529_016970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_016980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K529_016990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K529_016995	COG4948	Mandelate Racemase Muconate Lactonizing
K529_017000	COG0640	Transcriptional regulator
K529_017005	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_017010	COG1132	(ABC) transporter
K529_017025	COG1522	sequence-specific DNA binding
K529_017045	COG0747	negative chemotaxis
K529_017050	COG0601	transmembrane transport
K529_017055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_017060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_017065	COG0668	transmembrane transport
K529_017085	COG0588	phosphoglycerate mutase activity
K529_017105	COG3454	Phosphonate metabolism
K529_017120	COG4778	phosphonate C-P lyase system protein PhnL
K529_017130	COG4107	phosphonate C-P lyase system protein PhnK
K529_017135	COG3627	carbon phosphorus lyase activity
K529_017140	COG3626	phosphonate metabolism
K529_017145	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
K529_017150	COG3624	Phosphonate C-P lyase system protein PhnG
K529_017155	COG2188	Transcriptional regulator
K529_017165	COG3639	organic phosphonate transmembrane transporter activity
K529_017170	COG3639	organic phosphonate transmembrane transporter activity
K529_017175	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K529_017185	COG0583	DNA-binding transcription factor activity
K529_017190	COG0300	oxidoreductase activity
K529_017205	COG5441	Belongs to the UPF0261 family
K529_017230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_017240	COG0174	glutamine synthetase
K529_017250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_017250	COG0519	Catalyzes the synthesis of GMP from XMP
K529_017260	COG3396	Phenylacetate-CoA oxygenase
K529_017265	COG3460	Phenylacetate-CoA oxygenase
K529_017270	COG3396	Phenylacetate-CoA oxygenase
K529_017275	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_017280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_017300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K529_017310	COG0456	acetyltransferase
K529_017315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K529_017340	COG3153	acetyltransferase
K529_017340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_017355	COG1530	ribonuclease E activity
K529_017360	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K529_017375	COG2132	Multicopper oxidase
K529_017385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_017400	COG2010	Cytochrome c
K529_017410	COG0714	Associated with various cellular activities
K529_017445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K529_017495	COG0494	nUDIX hydrolase
K529_017580	COG1280	lysine exporter protein (LysE YggA)
K529_017605	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_017610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_017615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K529_017650	COG0583	DNA-binding transcription factor activity
K529_017665	COG1960	acyl-CoA dehydrogenase activity
K529_017670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_017675	COG0583	DNA-binding transcription factor activity
K529_017695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K529_017755	COG0402	S-adenosylhomocysteine deaminase activity
K529_017765	COG0583	DNA-binding transcription factor activity
K529_017770	COG2351	hydroxyisourate hydrolase activity
K529_017780	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K529_017790	COG3257	ureidoglycine aminohydrolase activity
K529_017795	COG2379	hydroxypyruvate reductase
K529_017810	COG1012	belongs to the aldehyde dehydrogenase family
K529_017825	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_017830	COG3971	2-oxopent-4-enoate hydratase activity
K529_017855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K529_017865	COG0288	reversible hydration of carbon dioxide
K529_017875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K529_017880	COG0791	NLP P60 protein
K529_017895	COG1309	transcriptional regulator
K529_017900	COG0679	Auxin Efflux Carrier
K529_017905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K529_017915	COG1671	Belongs to the UPF0178 family
K529_017930	COG3474	cytochrome
K529_017935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K529_017945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K529_017970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_017985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K529_017990	COG2198	Histidine kinase
K529_017990	COG0784	Response regulator, receiver
K529_017990	COG5002	protein histidine kinase activity
K529_017995	COG1335	isochorismatase
K529_018000	COG1054	Belongs to the UPF0176 family
K529_018015	COG0012	GTP binding
K529_018025	COG0159	tryptophan synthase activity
K529_018030	COG0784	Response regulator, receiver
K529_018030	COG2205	protein histidine kinase activity
K529_018040	COG0738	Major facilitator superfamily
K529_018050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K529_018060	COG0193	aminoacyl-tRNA hydrolase activity
K529_018070	COG0004	ammonium transporteR
K529_018075	COG0133	tryptophan synthase activity
K529_018080	COG0583	DNA-binding transcription factor activity
K529_018085	COG0135	phosphoribosylanthranilate isomerase activity
K529_018095	COG0776	regulation of translation
K529_018100	COG3443	Belongs to the bacterial solute-binding protein 9 family
K529_018105	COG0539	negative regulation of cytoplasmic translation
K529_018115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K529_018135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K529_018145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K529_018150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K529_018155	COG1253	flavin adenine dinucleotide binding
K529_018160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K529_018170	COG1702	phosphate starvation-inducible protein PhoH
K529_018185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_018200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K529_018205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K529_018210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K529_018235	COG0587	DNA-directed DNA polymerase activity
K529_018240	COG3300	MHYT domain
K529_018240	COG5001	Diguanylate cyclase
K529_018255	COG0737	Belongs to the 5'-nucleotidase family
K529_018280	COG1335	isochorismatase
K529_018290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K529_018295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K529_018310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_018320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_018340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_018345	COG0028	Belongs to the TPP enzyme family
K529_018355	COG2855	membrane
K529_018360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_018365	COG1595	DNA-templated transcription, initiation
K529_018370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_018385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_018385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K529_018400	COG0556	nucleotide-excision repair
K529_018430	COG4691	Plasmid stability protein
K529_018500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_018530	COG4774	siderophore transport
K529_018535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_018540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_018570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K529_018585	COG1475	DNA binding
K529_018590	COG1192	Involved in chromosome partitioning
K529_018600	COG0318	PFAM AMP-dependent synthetase and ligase
K529_018615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_018615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_018620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_018650	COG1805	sodium ion transport
K529_018660	COG1477	protein flavinylation
K529_018670	COG1063	alcohol dehydrogenase
K529_018675	COG2207	Transcriptional regulator
K529_018675	COG3708	Transcriptional regulator
K529_018680	COG1879	ABC-type sugar transport system periplasmic component
K529_018690	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_018705	COG0095	Lipoate-protein ligase
K529_018715	COG2011	ABC-type metal ion transport system permease component
K529_018720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K529_018750	COG1653	transport
K529_018755	COG0395	ABC-type sugar transport system, permease component
K529_018760	COG1175	transmembrane transport
K529_018775	COG3119	arylsulfatase activity
K529_018825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K529_018840	COG5002	protein histidine kinase activity
K529_018840	COG2176	DNA-directed DNA polymerase activity
K529_018845	COG0583	DNA-binding transcription factor activity
K529_018850	COG1960	acyl-CoA dehydrogenase activity
K529_018855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_018865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_018870	COG0183	Belongs to the thiolase family
K529_018875	COG1129	ABC transporter
K529_018880	COG4214	carbohydrate transport
K529_018885	COG4213	ABC transporter substrate-binding protein
K529_018920	COG1595	DNA-templated transcription, initiation
K529_018940	COG3384	dioxygenase
K529_018950	COG4948	Mandelate Racemase Muconate Lactonizing
K529_018960	COG2301	Belongs to the HpcH HpaI aldolase family
K529_018985	COG0825	malonyl-CoA metabolic process
K529_019000	COG1309	transcriptional regulator
K529_019010	COG0673	inositol 2-dehydrogenase activity
K529_019015	COG0395	ABC-type sugar transport system, permease component
K529_019020	COG1175	transmembrane transport
K529_019030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K529_019040	COG2188	Transcriptional regulator
K529_019045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K529_019050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K529_019055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K529_019065	COG0243	molybdopterin cofactor binding
K529_019075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_019090	COG0747	negative chemotaxis
K529_019095	COG0747	negative chemotaxis
K529_019110	COG0444	Belongs to the ABC transporter superfamily
K529_019115	COG4608	Belongs to the ABC transporter superfamily
K529_019120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K529_019130	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_019130	COG1902	pentaerythritol trinitrate reductase activity
K529_019135	COG5001	Diguanylate cyclase
K529_019140	COG1858	cytochrome C peroxidase
K529_019145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_019160	COG2390	Transcriptional regulator
K529_019170	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_019180	COG1879	ABC-type sugar transport system periplasmic component
K529_019185	COG1028	Short-chain dehydrogenase reductase Sdr
K529_019185	COG3347	Dehydrogenase
K529_019190	COG3119	arylsulfatase activity
K529_019200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_019215	COG1609	Transcriptional regulator
K529_019235	COG3772	lysozyme
K529_019310	COG0740	serine-type endopeptidase activity
K529_019375	COG0629	single-stranded DNA binding
K529_019400	COG4974	Belongs to the 'phage' integrase family
K529_019435	COG3293	Transposase
K529_019455	COG3772	lysozyme
K529_019530	COG0667	Aldo Keto reductase
K529_019535	COG0583	DNA-binding transcription factor activity
K529_019550	COG3293	Transposase
K529_019570	COG1686	Belongs to the peptidase S11 family
K529_019575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K529_019585	COG0084	hydrolase, TatD family'
K529_019590	COG1234	tRNA 3'-trailer cleavage
K529_019615	COG4608	Belongs to the ABC transporter superfamily
K529_019620	COG0444	Belongs to the ABC transporter superfamily
K529_019625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_019630	COG0601	transmembrane transport
K529_019635	COG0747	negative chemotaxis
K529_019645	COG3852	Histidine kinase
K529_019665	COG3639	organic phosphonate transmembrane transporter activity
K529_019680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K529_019685	COG0252	asparaginase activity
K529_019690	COG1115	amino acid carrier protein
K529_019700	COG0574	Belongs to the PEP-utilizing enzyme family
K529_019700	COG3848	Pyruvate phosphate dikinase
K529_019715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_019735	COG3938	Belongs to the proline racemase family
K529_019740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_019745	COG3938	Belongs to the proline racemase family
K529_019750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_019765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_019770	COG0840	transmembrane signaling receptor activity
K529_019785	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K529_019790	COG3383	formate dehydrogenase (NAD+) activity
K529_019850	COG4774	siderophore transport
K529_019860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_019865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_019870	COG1120	ATPase activity
K529_019875	COG0642	Histidine kinase
K529_019880	COG0745	RESPONSE REGULATOR receiver
K529_019900	COG4208	sulfate ABC transporter
K529_019905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K529_019915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K529_019915	COG3008	intermembrane lipid transfer
K529_019920	COG2995	paraquat-inducible protein a
K529_019925	COG2995	paraquat-inducible protein a
K529_019935	COG1115	amino acid carrier protein
K529_019945	COG1802	Transcriptional regulator
K529_019950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K529_019960	COG1012	belongs to the aldehyde dehydrogenase family
K529_019970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_019985	COG2031	fatty acid transporter
K529_019990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K529_019995	COG3842	ATPase activity
K529_020010	COG1840	ABC-type Fe3 transport system, periplasmic component
K529_020015	COG1609	Transcriptional regulator
K529_020020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K529_020025	COG2723	6-phospho-beta-galactosidase activity
K529_020030	COG1609	Transcriptional regulator
K529_020035	COG1653	transport
K529_020040	COG1175	transmembrane transport
K529_020045	COG0395	ABC-type sugar transport system, permease component
K529_020050	COG0366	Alpha amylase catalytic
K529_020055	COG3842	ATPase activity
K529_020070	COG3293	Transposase
K529_020085	COG0745	RESPONSE REGULATOR receiver
K529_020090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K529_020105	COG0745	RESPONSE REGULATOR receiver
K529_020115	COG0840	transmembrane signaling receptor activity
K529_020120	COG2201	protein-glutamate methylesterase activity
K529_020130	COG1309	transcriptional regulator
K529_020140	COG0395	ABC-type sugar transport system, permease component
K529_020150	COG1653	transport
K529_020155	COG3842	ATPase activity
K529_020165	COG4638	Rieske (2fe-2S)
K529_020185	COG2204	response regulator
K529_020190	COG4251	negative regulation of phosphorylation
K529_020200	COG5002	protein histidine kinase activity
K529_020200	COG3850	Histidine kinase
K529_020210	COG1183	phosphatidylcholine synthase activity
K529_020230	COG0646	methionine synthase
K529_020230	COG1410	methionine synthase
K529_020250	COG1012	belongs to the aldehyde dehydrogenase family
K529_020265	COG0072	phenylalanine-tRNA ligase activity
K529_020265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_020275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K529_020300	COG0668	transmembrane transport
K529_020305	COG0686	Belongs to the AlaDH PNT family
K529_020310	COG1522	sequence-specific DNA binding
K529_020315	COG2326	polyphosphate kinase activity
K529_020320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K529_020330	COG0314	molybdopterin synthase activity
K529_020345	COG2885	chlorophyll binding
K529_020350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K529_020355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K529_020390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K529_020400	COG0540	Belongs to the ATCase OTCase family
K529_020405	COG1678	Uncharacterized ACR, COG1678
K529_020420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_020430	COG0521	Mo-molybdopterin cofactor biosynthetic process
K529_020435	COG1280	lysine exporter protein (LysE YggA)
K529_020445	COG1573	uracil-dna glycosylase
K529_020450	COG0009	L-threonylcarbamoyladenylate synthase
K529_020455	COG1960	acyl-CoA dehydrogenase activity
K529_020470	COG1914	H( )-stimulated, divalent metal cation uptake system
K529_020475	COG1321	iron dependent repressor
K529_020510	COG0746	molybdenum cofactor guanylyltransferase activity
K529_020530	COG0456	acetyltransferase
K529_020540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K529_020550	COG0789	Transcriptional regulator
K529_020565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K529_020570	COG0142	geranyltranstransferase activity
K529_020590	COG0583	DNA-binding transcription factor activity
K529_020595	COG1028	Short-chain dehydrogenase reductase Sdr
K529_020610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_020615	COG0165	Argininosuccinate lyase
K529_020620	COG0019	diaminopimelate decarboxylase activity
K529_020635	COG2884	Cell division ATP-binding protein ftsE
K529_020690	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_020700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K529_020715	COG0045	succinate-CoA ligase (ADP-forming) activity
K529_020730	COG0039	L-malate dehydrogenase activity
K529_020755	COG2030	dehydratase
K529_020825	COG0813	purine-nucleoside phosphorylase activity
K529_020835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_020835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_020840	COG2937	Belongs to the GPAT DAPAT family
K529_020845	COG0604	alcohol dehydrogenase
K529_020860	COG1028	Short-chain dehydrogenase reductase Sdr
K529_020870	COG0730	response to heat
K529_020875	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_020880	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_020885	COG3845	ABC transporter
K529_020890	COG1744	ABC transporter substrate-binding protein PnrA-like
K529_020900	COG1214	PFAM Peptidase M22, glycoprotease
K529_020910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K529_020960	COG3293	Transposase
K529_021005	COG0321	lipoyl(octanoyl) transferase activity
K529_021010	COG3842	ATPase activity
K529_021020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K529_021035	COG2182	Extracellular solute-binding protein
K529_021060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K529_021075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_021090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K529_021100	COG0439	Biotin carboxylase
K529_021110	COG1984	allophanate hydrolase subunit 2
K529_021115	COG1879	ABC-type sugar transport system periplasmic component
K529_021120	COG1129	ABC transporter
K529_021125	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_021135	COG3181	Tripartite tricarboxylate transporter family receptor
K529_021150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_021185	COG0517	IMP dehydrogenase activity
K529_021190	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K529_021220	COG0187	DNA topoisomerase II activity
K529_021245	COG0534	Mate efflux family protein
K529_021270	COG1846	Transcriptional regulator
K529_021280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K529_021290	COG1278	Cold shock
K529_021295	COG1393	Belongs to the ArsC family
K529_021310	COG3220	belongs to the UPF0276 family
K529_021320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K529_021350	COG3243	poly(R)-hydroxyalkanoic acid synthase
K529_021395	COG0525	valine-tRNA ligase activity
K529_021425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K529_021470	COG1028	Short-chain dehydrogenase reductase Sdr
K529_021475	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_021480	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_021485	COG1129	ABC transporter
K529_021495	COG0559	Belongs to the binding-protein-dependent transport system permease family
K529_021500	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_021515	COG1017	nitric oxide dioxygenase activity
K529_021515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_021530	COG4608	Belongs to the ABC transporter superfamily
K529_021535	COG0747	negative chemotaxis
K529_021540	COG0601	transmembrane transport
K529_021545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_021550	COG0405	Gamma-glutamyltransferase
K529_021560	COG2186	Transcriptional regulator
K529_021570	COG0444	Belongs to the ABC transporter superfamily
K529_021575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_021580	COG0601	transmembrane transport
K529_021590	COG1233	COG1233 Phytoene dehydrogenase and related
K529_021595	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K529_021625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K529_021635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K529_021645	COG1215	transferase activity, transferring glycosyl groups
K529_021650	COG1215	transferase activity, transferring glycosyl groups
K529_021655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K529_021675	COG1414	Transcriptional regulator
K529_021680	COG1475	DNA binding
K529_021685	COG1192	Involved in chromosome partitioning
K529_021690	COG0583	DNA-binding transcription factor activity
K529_021760	COG1028	Short-chain dehydrogenase reductase Sdr
K529_021765	COG1028	Short-chain dehydrogenase reductase Sdr
K529_021770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K529_021775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_021780	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_021785	COG0022	dehydrogenase e1 component
K529_021785	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_021790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_021795	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_021800	COG1129	ABC transporter
K529_021815	COG0402	S-adenosylhomocysteine deaminase activity
K529_021830	COG3845	ABC transporter
K529_021835	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_021840	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_021845	COG2358	TRAP transporter, solute receptor (TAXI family
K529_021850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_021855	COG0415	Belongs to the DNA photolyase family
K529_021880	COG4172	Belongs to the ABC transporter superfamily
K529_021900	COG1720	tRNA m6t6A37 methyltransferase activity
K529_021965	COG0596	Alpha beta hydrolase
K529_021995	COG0318	PFAM AMP-dependent synthetase and ligase
K529_022005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K529_022015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K529_022025	COG1136	(ABC) transporter
K529_022040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_022060	COG2207	Transcriptional regulator
K529_022060	COG3708	Transcriptional regulator
K529_022070	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_022080	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_022085	COG0022	dehydrogenase e1 component
K529_022090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_022125	COG4232	protein-disulfide reductase activity
K529_022145	COG2217	Heavy metal translocating P-type atpase
K529_022155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_022155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_022165	COG2132	Multicopper oxidase
K529_022190	COG1376	ErfK ybiS ycfS ynhG family protein
K529_022220	COG4235	cytochrome complex assembly
K529_022225	COG3088	subunit of a heme lyase
K529_022230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_022235	COG1138	Cytochrome C-type biogenesis protein
K529_022250	COG2132	Multicopper oxidase
K529_022280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K529_022305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_022335	COG0798	PFAM Bile acid sodium symporter
K529_022345	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K529_022350	COG1192	Involved in chromosome partitioning
K529_022475	COG0789	Transcriptional regulator
K529_022480	COG1999	signal sequence binding
K529_022490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_022500	COG1999	signal sequence binding
K529_022525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K529_022530	COG2366	antibiotic biosynthetic process
K529_022540	COG1321	iron dependent repressor
K529_022555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K529_022565	COG3034	peptidoglycan biosynthetic process
K529_022610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_022615	COG2124	cytochrome p450
K529_022630	COG0785	Cytochrome C biogenesis protein
K529_022650	COG1999	signal sequence binding
K529_022655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_022655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_022670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_022675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_022695	COG2132	Multicopper oxidase
K529_022710	COG4941	Belongs to the sigma-70 factor family
K529_022715	COG3795	YCII-related domain
K529_022725	COG0517	IMP dehydrogenase activity
K529_022725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K529_022755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K529_022815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_022830	COG1192	Involved in chromosome partitioning
K529_022925	COG1088	dTDP-glucose 4,6-dehydratase activity
K529_022935	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K529_022945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity