locus-tag	class	description
TW002	COG0592	DNA-directed DNA polymerase activity
TW005	COG0187	DNA topoisomerase II activity
TW006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TW008	COG1564	THIamine pyrophosphokinase
TW012	COG1704	LemA family
TW017	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW020	COG4770	biotin carboxylase activity
TW025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TW035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TW042	COG1216	Glycosyl transferase, family 2
TW055	COG0745	RESPONSE REGULATOR receiver
TW057	COG1278	Cold shock
TW060	COG0287	Prephenate dehydrogenase
TW061	COG1160	GTP binding
TW062	COG1169	isochorismate synthase
TW068	COG1120	ATPase activity
TW069	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW071	COG0640	Transcriptional regulator
TW072	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TW074	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TW075	COG0542	response to heat
TW078	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TW084	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TW086	COG0516	GMP reductase activity
TW093	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TW094	COG0138	bifunctional purine biosynthesis protein purh
TW098	COG0750	zinc metalloprotease
TW100	COG0631	protein serine/threonine phosphatase activity
TW106	COG1131	(ABC) transporter
TW108	COG4974	Belongs to the 'phage' integrase family
TW120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TW128	COG0776	regulation of translation
TW130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TW132	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
TW133	COG1482	cell wall glycoprotein biosynthetic process
TW137	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW148	COG1122	ATPase activity
TW149	COG0601	transmembrane transport
TW150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TW153	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TW162	COG1132	(ABC) transporter
TW163	COG1132	(ABC) transporter
TW167	COG0802	atpase or kinase
TW169	COG0456	acetyltransferase
TW169	COG1214	PFAM Peptidase M22, glycoprotease
TW173	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TW174	COG0302	gtp cyclohydrolase
TW175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TW177	COG1137	ATPase activity
TW180	COG0196	riboflavin kinase activity
TW204	COG0410	ABC transporter
TW209	COG0089	rRNA binding
TW237	COG2239	Acts as a magnesium transporter
TW238	COG0006	proline dipeptidase activity
TW243	COG0210	DNA helicase
TW247	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TW249	COG3599	regulation of cell shape
TW253	COG0861	Integral membrane protein TerC family
TW254	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TW255	COG0204	Acyl-transferase
TW259	COG0508	dehydrogenase complex catalyzes the overall conversion of
TW260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TW262	COG0751	glycine-tRNA ligase activity
TW262	COG0752	glycyl-tRNA synthetase alpha subunit
TW263	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TW266	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TW267	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TW268	COG0187	DNA topoisomerase II activity
TW272	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TW273	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TW281	COG0544	peptidyl-prolyl cis-trans isomerase activity
TW284	COG0740	serine-type endopeptidase activity
TW288	COG0285	dihydrofolate synthase activity
TW290	COG0105	UTP biosynthetic process
TW291	COG1530	ribonuclease E activity
TW302	COG0321	lipoyl(octanoyl) transferase activity
TW303	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TW305	COG1837	Belongs to the UPF0109 family
TW306	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TW313	COG0606	chelatase, subunit chli
TW314	COG0758	DNA mediated transformation
TW315	COG4974	Belongs to the 'phage' integrase family
TW322	COG0575	Belongs to the CDS family
TW329	COG0460	homoserine dehydrogenase
TW330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TW331	COG0083	homoserine kinase activity
TW333	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TW334	COG2890	protein-(glutamine-N5) methyltransferase activity
TW336	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TW338	COG0356	it plays a direct role in the translocation of protons across the membrane
TW343	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TW345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TW352	COG1104	cysteine desulfurase activity
TW355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TW361	COG3845	ABC transporter
TW372	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TW376	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TW384	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TW386	COG1555	photosystem II stabilization
TW386	COG1596	polysaccharide export
TW396	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TW398	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TW400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TW402	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TW403	COG0505	Belongs to the CarA family
TW404	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TW405	COG0284	orotidine-5'-phosphate decarboxylase activity
TW411	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TW415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TW416	COG0573	inorganic phosphate transmembrane transporter activity
TW421	COG1329	Transcriptional regulator
TW424	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TW429	COG0166	Belongs to the GPI family
TW430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TW433	COG1612	heme a metabolic process
TW434	COG0719	Fe-S assembly protein
TW437	COG0396	ATPase activity
TW438	COG2151	metal-sulfur cluster biosynthetic enzyme
TW442	COG4214	carbohydrate transport
TW443	COG4213	ABC transporter substrate-binding protein
TW445	COG1063	alcohol dehydrogenase
TW446	COG0084	hydrolase, TatD family'
TW451	COG0805	protein transport
TW459	COG1028	Short-chain dehydrogenase reductase Sdr
TW460	COG0438	transferase activity, transferring glycosyl groups
TW464	COG0363	glucosamine-6-phosphate deaminase activity
TW465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TW472	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TW478	COG0237	dephospho-CoA kinase activity
TW480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW482	COG0469	pyruvate kinase activity
TW483	COG0791	NLP P60 protein
TW485	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TW486	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TW487	COG1381	Involved in DNA repair and RecF pathway recombination
TW490	COG0537	adenosine 5'-monophosphoramidase activity
TW491	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TW496	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TW498	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TW499	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TW502	COG0632	four-way junction helicase activity
TW503	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TW504	COG0217	transcriptional regulatory protein
TW513	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TW515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TW519	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TW521	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TW522	COG0723	plastoquinol--plastocyanin reductase activity
TW523	COG2010	Cytochrome c
TW524	COG1845	cytochrome c oxidase, subunit III
TW526	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TW527	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TW529	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TW532	COG0167	dihydroorotate dehydrogenase activity
TW541	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TW543	COG0772	Belongs to the SEDS family
TW547	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TW554	COG0142	geranyltranstransferase activity
TW555	COG2815	serine threonine protein kinase
TW555	COG0515	serine threonine protein kinase
TW556	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TW558	COG1940	carbohydrate kinase activity
TW560	COG1268	BioY protein
TW562	COG0492	ferredoxin-NADP+ reductase activity
TW564	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TW566	COG0440	acetolactate synthase activity
TW569	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TW573	COG2884	Cell division ATP-binding protein ftsE
TW574	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TW576	COG0540	Belongs to the ATCase OTCase family
TW585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TW592	COG1131	(ABC) transporter
TW610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TW618	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TW620	COG0343	queuine tRNA-ribosyltransferase activity
TW626	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TW632	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TW633	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TW643	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TW647	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TW648	COG1192	Involved in chromosome partitioning
TW656	COG0742	ribosomal rna small subunit methyltransferase
TW659	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TW661	COG0012	GTP binding
TW666	COG1722	exodeoxyribonuclease VII activity
TW667	COG2271	Major facilitator Superfamily
TW684	COG1970	mechanosensitive ion channel activity
TW685	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TW686	COG1121	(ABC) transporter
TW687	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TW699	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TW700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TW701	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW702	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TW702	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW707	COG0307	riboflavin synthase, alpha
TW708	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW708	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW711	COG1335	isochorismatase
TW713	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TW715	COG1754	DNA topoisomerase type I activity
TW715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TW721	COG0251	oxidation-reduction process
TW722	COG4499	WXG100 protein secretion system (Wss), protein YukC
TW722	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TW725	COG0527	aspartate kinase activity
TW733	COG0436	Aminotransferase
TW736	COG2030	dehydratase
TW738	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TW739	COG0151	Belongs to the GarS family
TW746	COG0181	hydroxymethylbilane synthase activity
TW751	COG4948	Mandelate Racemase Muconate Lactonizing
TW752	COG0305	Participates in initiation and elongation during chromosome replication
TW756	COG0708	Exodeoxyribonuclease III
TW759	COG0789	Transcriptional regulator
TW763	COG0590	tRNA wobble adenosine to inosine editing
TW766	COG0017	Asparaginyl-tRNA synthetase
TW767	COG0406	alpha-ribazole phosphatase activity
TW768	COG3118	belongs to the thioredoxin family
TW769	COG0785	Cytochrome C biogenesis protein
TW770	COG1333	cytochrome c biogenesis protein
TW771	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TW773	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TW775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW777	COG0463	Glycosyl transferase, family 2
TW781	COG3590	peptidase
TW782	COG0546	phosphoglycolate phosphatase activity
TW787	COG0768	penicillin binding
TW788	COG0515	serine threonine protein kinase
TW789	COG2815	serine threonine protein kinase
TW789	COG0515	serine threonine protein kinase
TW797	COG0508	dehydrogenase complex catalyzes the overall conversion of
TW798	COG0022	dehydrogenase e1 component
TW805	COG0047	phosphoribosylformylglycinamidine synthase activity
TW811	COG1475	DNA binding
TW812	COG1192	Involved in chromosome partitioning
TW813	COG2217	Heavy metal translocating P-type atpase
TW817	COG0594	ribonuclease P activity