locus-tag	class	description
TWT_002	COG0592	DNA-directed DNA polymerase activity
TWT_005	COG0187	DNA topoisomerase II activity
TWT_006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TWT_008	COG1564	THIamine pyrophosphokinase
TWT_012	COG1704	LemA family
TWT_013	COG0501	Belongs to the peptidase M48B family
TWT_017	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TWT_020	COG4770	biotin carboxylase activity
TWT_023	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TWT_031	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TWT_038	COG1216	Glycosyl transferase, family 2
TWT_047	COG0745	RESPONSE REGULATOR receiver
TWT_048	COG1278	Cold shock
TWT_050	COG0287	Prephenate dehydrogenase
TWT_051	COG1160	GTP binding
TWT_052	COG1169	isochorismate synthase
TWT_058	COG1120	ATPase activity
TWT_059	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TWT_060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TWT_061	COG0640	Transcriptional regulator
TWT_062	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TWT_064	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TWT_065	COG0542	response to heat
TWT_068	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TWT_071	COG0085	RNA polymerase activity
TWT_072	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TWT_074	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TWT_076	COG0516	GMP reductase activity
TWT_079	COG0519	Catalyzes the synthesis of GMP from XMP
TWT_079	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TWT_083	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TWT_084	COG0138	bifunctional purine biosynthesis protein purh
TWT_087	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TWT_088	COG0750	zinc metalloprotease
TWT_089	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TWT_090	COG0631	protein serine/threonine phosphatase activity
TWT_094	COG1131	(ABC) transporter
TWT_097	COG4974	Belongs to the 'phage' integrase family
TWT_100	COG0504	CTP synthase activity
TWT_102	COG0497	DNA recombination
TWT_103	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TWT_105	COG0359	binds to the 23S rRNA
TWT_107	COG0629	single-stranded DNA binding
TWT_108	COG0360	Binds together with S18 to 16S ribosomal RNA
TWT_109	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TWT_110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TWT_116	COG0776	regulation of translation
TWT_118	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TWT_120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TWT_121	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
TWT_122	COG1482	cell wall glycoprotein biosynthetic process
TWT_127	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TWT_135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TWT_135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TWT_139	COG1122	ATPase activity
TWT_140	COG0601	transmembrane transport
TWT_141	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TWT_144	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TWT_152	COG0343	queuine tRNA-ribosyltransferase activity
TWT_154	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TWT_157	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TWT_162	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TWT_166	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TWT_167	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TWT_168	COG0072	phenylalanine-tRNA ligase activity
TWT_168	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TWT_177	COG1131	(ABC) transporter
TWT_183	COG0442	prolyl-tRNA aminoacylation
TWT_187	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TWT_188	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TWT_196	COG0540	Belongs to the ATCase OTCase family
TWT_198	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TWT_199	COG2884	Cell division ATP-binding protein ftsE
TWT_201	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TWT_203	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TWT_204	COG0129	dihydroxy-acid dehydratase activity
TWT_205	COG0028	Belongs to the TPP enzyme family
TWT_206	COG0440	acetolactate synthase activity
TWT_207	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TWT_208	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TWT_210	COG0492	ferredoxin-NADP+ reductase activity
TWT_210	COG0492	ferredoxin-NADP+ reductase activity
TWT_211	COG1268	BioY protein
TWT_213	COG1940	carbohydrate kinase activity
TWT_215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TWT_216	COG0515	serine threonine protein kinase
TWT_216	COG2815	serine threonine protein kinase
TWT_217	COG0142	geranyltranstransferase activity
TWT_219	COG2001	Belongs to the MraZ family
TWT_223	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TWT_225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TWT_226	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TWT_227	COG0772	Belongs to the SEDS family
TWT_229	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TWT_238	COG0167	dihydroorotate dehydrogenase activity
TWT_241	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TWT_243	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TWT_244	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TWT_246	COG1845	cytochrome c oxidase, subunit III
TWT_247	COG2010	Cytochrome c
TWT_248	COG0723	plastoquinol--plastocyanin reductase activity
TWT_249	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TWT_251	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TWT_255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TWT_257	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TWT_260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TWT_262	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TWT_264	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TWT_265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TWT_266	COG0217	transcriptional regulatory protein
TWT_267	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TWT_268	COG0632	four-way junction helicase activity
TWT_271	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TWT_272	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TWT_275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TWT_278	COG0481	GTPase activity
TWT_280	COG0484	heat shock protein binding
TWT_281	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TWT_282	COG0537	adenosine 5'-monophosphoramidase activity
TWT_285	COG1381	Involved in DNA repair and RecF pathway recombination
TWT_286	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TWT_287	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TWT_289	COG0791	NLP P60 protein
TWT_290	COG0469	pyruvate kinase activity
TWT_292	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TWT_292	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TWT_294	COG0237	dephospho-CoA kinase activity
TWT_297	COG0322	excinuclease ABC activity
TWT_300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TWT_301	COG0126	phosphoglycerate kinase activity
TWT_302	COG0149	triose-phosphate isomerase activity
TWT_307	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TWT_308	COG0363	glucosamine-6-phosphate deaminase activity
TWT_309	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TWT_310	COG0242	peptide deformylase activity
TWT_312	COG0438	transferase activity, transferring glycosyl groups
TWT_313	COG1028	Short-chain dehydrogenase reductase Sdr
TWT_315	COG1968	undecaprenyl-diphosphatase activity
TWT_320	COG0805	protein transport
TWT_325	COG0084	hydrolase, TatD family'
TWT_326	COG1063	alcohol dehydrogenase
TWT_328	COG4213	ABC transporter substrate-binding protein
TWT_329	COG4214	carbohydrate transport
TWT_331	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TWT_333	COG2151	metal-sulfur cluster biosynthetic enzyme
TWT_334	COG0396	ATPase activity
TWT_337	COG0719	Fe-S assembly protein
TWT_338	COG1612	heme a metabolic process
TWT_341	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TWT_342	COG0166	Belongs to the GPI family
TWT_346	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TWT_349	COG1329	Transcriptional regulator
TWT_351	COG0018	arginyl-trna synthetase
TWT_352	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TWT_354	COG0573	inorganic phosphate transmembrane transporter activity
TWT_355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TWT_358	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TWT_360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TWT_362	COG1758	RNA polymerase activity
TWT_364	COG0284	orotidine-5'-phosphate decarboxylase activity
TWT_365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TWT_366	COG0505	Belongs to the CarA family
TWT_367	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TWT_369	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TWT_370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TWT_371	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TWT_373	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TWT_384	COG1596	polysaccharide export
TWT_384	COG1555	photosystem II stabilization
TWT_385	COG0495	leucyl-tRNA aminoacylation
TWT_386	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TWT_394	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TWT_398	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TWT_406	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TWT_408	COG3845	ABC transporter
TWT_411	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TWT_412	COG0154	amidase activity
TWT_413	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TWT_414	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TWT_415	COG0482	sulfurtransferase activity
TWT_416	COG1104	cysteine desulfurase activity
TWT_421	COG1185	polyribonucleotide nucleotidyltransferase activity
TWT_423	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TWT_425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TWT_430	COG0356	it plays a direct role in the translocation of protons across the membrane
TWT_432	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TWT_434	COG2890	protein-(glutamine-N5) methyltransferase activity
TWT_435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TWT_437	COG0083	homoserine kinase activity
TWT_438	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TWT_439	COG0460	homoserine dehydrogenase
TWT_445	COG0575	Belongs to the CDS family
TWT_448	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TWT_452	COG4974	Belongs to the 'phage' integrase family
TWT_453	COG0758	DNA mediated transformation
TWT_454	COG0606	chelatase, subunit chli
TWT_455	COG0792	nuclease activity
TWT_458	COG0336	Belongs to the RNA methyltransferase TrmD family
TWT_459	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TWT_460	COG1837	Belongs to the UPF0109 family
TWT_461	COG0228	four-way junction DNA binding
TWT_462	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TWT_463	COG0321	lipoyl(octanoyl) transferase activity
TWT_469	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TWT_471	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TWT_472	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TWT_473	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TWT_474	COG1530	ribonuclease E activity
TWT_475	COG0105	UTP biosynthetic process
TWT_476	COG0285	dihydrofolate synthase activity
TWT_478	COG0525	valine-tRNA ligase activity
TWT_479	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TWT_480	COG0740	serine-type endopeptidase activity
TWT_483	COG0544	peptidyl-prolyl cis-trans isomerase activity
TWT_491	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TWT_492	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TWT_494	COG0187	DNA topoisomerase II activity
TWT_495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TWT_496	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TWT_499	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TWT_500	COG0752	glycyl-tRNA synthetase alpha subunit
TWT_500	COG0751	glycine-tRNA ligase activity
TWT_502	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TWT_503	COG0508	dehydrogenase complex catalyzes the overall conversion of
TWT_505	COG1181	Belongs to the D-alanine--D-alanine ligase family
TWT_506	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TWT_507	COG0204	Acyl-transferase
TWT_508	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TWT_509	COG0861	Integral membrane protein TerC family
TWT_510	COG0587	DNA-directed DNA polymerase activity
TWT_512	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TWT_513	COG3599	regulation of cell shape
TWT_515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TWT_519	COG0210	DNA helicase
TWT_522	COG0006	proline dipeptidase activity
TWT_523	COG2239	Acts as a magnesium transporter
TWT_526	COG0101	tRNA pseudouridine synthase activity
TWT_536	COG0200	Binds to the 23S rRNA
TWT_537	COG1841	ribosomal large subunit assembly
TWT_546	COG0255	Belongs to the universal ribosomal protein uL29 family
TWT_552	COG0089	rRNA binding
TWT_553	COG0088	Forms part of the polypeptide exit tunnel
TWT_557	COG0410	ABC transporter
TWT_581	COG0196	riboflavin kinase activity
TWT_584	COG1137	ATPase activity
TWT_586	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TWT_587	COG0302	gtp cyclohydrolase
TWT_588	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TWT_590	COG0037	tRNA processing
TWT_592	COG1214	PFAM Peptidase M22, glycoprotease
TWT_592	COG0456	acetyltransferase
TWT_593	COG0802	atpase or kinase
TWT_600	COG1132	(ABC) transporter
TWT_601	COG1132	(ABC) transporter
TWT_605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TWT_606	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TWT_609	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TWT_610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TWT_614	COG1674	ftsk spoiiie
TWT_615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TWT_616	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TWT_621	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TWT_625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TWT_630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TWT_631	COG1192	Involved in chromosome partitioning
TWT_634	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TWT_636	COG0742	ribosomal rna small subunit methyltransferase
TWT_638	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TWT_639	COG0012	GTP binding
TWT_642	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TWT_644	COG1722	exodeoxyribonuclease VII activity
TWT_645	COG2271	Major facilitator Superfamily
TWT_651	COG0193	aminoacyl-tRNA hydrolase activity
TWT_654	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TWT_661	COG1970	mechanosensitive ion channel activity
TWT_663	COG1121	(ABC) transporter
TWT_664	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TWT_675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TWT_680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TWT_681	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TWT_682	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TWT_683	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TWT_683	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TWT_686	COG0180	Tryptophanyl-tRNA synthetase
TWT_688	COG0307	riboflavin synthase, alpha
TWT_689	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TWT_689	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TWT_692	COG1335	isochorismatase
TWT_694	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TWT_696	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TWT_696	COG1754	DNA topoisomerase type I activity
TWT_702	COG0251	oxidation-reduction process
TWT_705	COG4499	WXG100 protein secretion system (Wss), protein YukC
TWT_705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TWT_708	COG0527	aspartate kinase activity
TWT_709	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TWT_711	COG0222	ribosome binding
TWT_716	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TWT_717	COG0436	Aminotransferase
TWT_718	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TWT_721	COG2030	dehydratase
TWT_724	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TWT_725	COG0151	Belongs to the GarS family
TWT_726	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TWT_732	COG0181	hydroxymethylbilane synthase activity
TWT_737	COG4948	Mandelate Racemase Muconate Lactonizing
TWT_738	COG0305	Participates in initiation and elongation during chromosome replication
TWT_743	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TWT_744	COG0708	Exodeoxyribonuclease III
TWT_746	COG0542	response to heat
TWT_747	COG0789	Transcriptional regulator
TWT_749	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TWT_751	COG0590	tRNA wobble adenosine to inosine editing
TWT_754	COG0017	Asparaginyl-tRNA synthetase
TWT_755	COG0406	alpha-ribazole phosphatase activity
TWT_756	COG3118	belongs to the thioredoxin family
TWT_757	COG0785	Cytochrome C biogenesis protein
TWT_758	COG1333	cytochrome c biogenesis protein
TWT_759	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TWT_761	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TWT_763	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TWT_765	COG0463	Glycosyl transferase, family 2
TWT_769	COG3590	peptidase
TWT_770	COG0546	phosphoglycolate phosphatase activity
TWT_776	COG0768	penicillin binding
TWT_777	COG0515	serine threonine protein kinase
TWT_778	COG0515	serine threonine protein kinase
TWT_778	COG2815	serine threonine protein kinase
TWT_786	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TWT_788	COG0508	dehydrogenase complex catalyzes the overall conversion of
TWT_789	COG0022	dehydrogenase e1 component
TWT_795	COG0047	phosphoribosylformylglycinamidine synthase activity
TWT_801	COG1475	DNA binding
TWT_802	COG1192	Involved in chromosome partitioning
TWT_803	COG2217	Heavy metal translocating P-type atpase
TWT_805	COG0706	membrane insertase activity
TWT_807	COG0594	ribonuclease P activity
TWT_808	COG0230	Belongs to the bacterial ribosomal protein bL34 family