locus-tag	class	description
AN946_00010	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AN946_00015	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
AN946_00020	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
AN946_00025	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
AN946_00035	ENOG4107R3N	Filamentation induced by cAMP protein fic
AN946_00040	ENOG4108TFM	Kinase, PfkB family
AN946_00050	ENOG4108KD5	ADP-ribosylation crystallin J1
AN946_00055	ENOG4105FDP	GntR family transcriptional regulator
AN946_00060	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
AN946_00065	ENOG4108RAV	Conserved protein
AN946_00105	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
AN946_00140	ENOG4105EWV	Sodium calcium exchanger membrane region
AN946_00150	ENOG4105CZV	ABC transporter
AN946_00155	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AN946_00180	ENOG4105DJZ	UPF0182 protein
AN946_00220	ENOG4105C31	Tryptophanyl-tRNA synthetase
AN946_00245	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AN946_00255	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
AN946_00260	ENOG4105CG3	alpha amylase, catalytic region
AN946_00265	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
AN946_00270	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
AN946_00280	ENOG4105EG2	ABC transporter, permease
AN946_00285	ENOG4105D56	permease protein
AN946_00295	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_00300	ENOG4105CG3	alpha amylase, catalytic region
AN946_00340	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
AN946_00350	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
AN946_00355	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
AN946_00360	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
AN946_00365	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
AN946_00370	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
AN946_00375	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
AN946_00380	ENOG4105ZA1	atp synthase
AN946_00385	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
AN946_00405	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
AN946_00410	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
AN946_00415	ENOG4105VFB	Binds the 23S rRNA (By similarity)
AN946_00425	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
AN946_00430	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
AN946_00435	ENOG4105D6E	homoserine dehydrogenase
AN946_00445	ENOG4105C75	arginyL-tRNA synthetase
AN946_00470	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AN946_00485	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
AN946_00500	ENOG4105C37	(CBS) domain
AN946_00505	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
AN946_00530	ENOG4105EMN	RNA polymerase sigma factor
AN946_00535	ENOG4105CE4	GlcNAc 6-P deacetylase
AN946_00540	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
AN946_00545	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
AN946_00555	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
AN946_00560	ENOG4108JQ7	(ABC) transporter
AN946_00565	ENOG4105C3U	ABC transporter
AN946_00610	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
AN946_00615	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AN946_00620	ENOG4107TK4	histidinol-phosphate phosphatase
AN946_00630	ENOG4105EYH	Exonuclease
AN946_00670	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AN946_00680	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AN946_00690	ENOG4105D65	subunit l
AN946_00695	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AN946_00700	ENOG41087XN	oxidoreductase
AN946_00705	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AN946_00710	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
AN946_00715	ENOG4108IEH	NADH dehydrogenase subunit g
AN946_00720	ENOG4107QIZ	NADH dehydrogenase
AN946_00730	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AN946_00735	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN946_00740	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
AN946_00750	ENOG4105P52	geranylgeranyl reductase
AN946_00755	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
AN946_00760	ENOG4105E4F	Isochorismate synthase
AN946_00775	ENOG4107TCW	O-succinylbenzoate synthase
AN946_00780	ENOG4107SIQ	Naphthoate synthase
AN946_00790	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
AN946_00795	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
AN946_00820	ENOG4108RH7	phosphoglycerate mutase
AN946_00825	ENOG4108ZT1	Transcriptional regulator
AN946_00835	ENOG4105CZN	Potassium uptake protein
AN946_00840	ENOG4107ZYR	domain protein
AN946_00845	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
AN946_00855	ENOG4105CEN	a g-specific adenine glycosylase
AN946_00870	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
AN946_00875	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
AN946_00880	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AN946_00885	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
AN946_00895	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
AN946_00900	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
AN946_00905	ENOG4105EYF	MMPL domain protein
AN946_00910	ENOG4105CRK	lysyL-tRNA synthetase
AN946_00920	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
AN946_00925	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
AN946_00935	ENOG4105CMT	Dihydroxyacetone kinase
AN946_00940	ENOG4108UTZ	Dihydroxyacetone kinase
AN946_00955	ENOG4105CNT	hydrolase family 2
AN946_00975	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_00995	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AN946_01005	ENOG4105EUJ	GTP cyclohydrolase i
AN946_01010	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
AN946_01015	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
AN946_01020	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
AN946_01035	ENOG4105F0N	pyrophosphate phospho-hydrolase
AN946_01045	ENOG4105DWV	Homoserine O-trans-acetylase
AN946_01050	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
AN946_01060	ENOG4105CQB	FAD linked oxidase domain protein
AN946_01065	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
AN946_01085	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
AN946_01090	ENOG4105CG3	alpha amylase, catalytic region
AN946_01110	ENOG4105DB4	
AN946_01135	ENOG4105KT7	mgtC SapB transporter
AN946_01140	ENOG4105C54	Major Facilitator superfamily
AN946_01160	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
AN946_01180	ENOG41089UC	methyltransferase, type 11
AN946_01185	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_01190	ENOG4105C2J	ABC transporter
AN946_01195	ENOG4105CNN	ABC, transporter
AN946_01200	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
AN946_01205	ENOG4108RVA	ribokinase
AN946_01210	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
AN946_01230	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
AN946_01240	ENOG4105C6Z	Gluconate
AN946_01245	ENOG41060NJ	transcriptional regulator
AN946_01255	ENOG4105CNT	hydrolase family 2
AN946_01275	ENOG4105CBG	Sulfatase
AN946_01280	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_01285	ENOG4105C54	Major Facilitator superfamily
AN946_01290	ENOG4105C4X	radical SAM domain protein
AN946_01295	ENOG4108VCT	Sulfite exporter TauE/SafE
AN946_01300	ENOG4107YVI	ribose 5-phosphate isomerase
AN946_01310	ENOG4105CMT	Dihydroxyacetone kinase
AN946_01315	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AN946_01320	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
AN946_01325	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
AN946_01335	ENOG4105EF1	ribulokinase
AN946_01340	ENOG4105D49	3-dehydroquinate synthase
AN946_01350	ENOG4105CMG	Carbohydrate kinase
AN946_01355	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
AN946_01365	ENOG4107RHR	regulatoR
AN946_01370	ENOG4105EDR	glucose galactose transporter
AN946_01380	ENOG4108RVA	ribokinase
AN946_01385	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AN946_01390	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
AN946_01400	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
AN946_01405	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
AN946_01415	ENOG4105CGH	5'-nucleotidase
AN946_01435	ENOG4105CJ3	phosphate transporter
AN946_01440	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
AN946_01455	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
AN946_01465	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
AN946_01495	ENOG4105E0X	reductase
AN946_01525	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AN946_01555	ENOG4105C94	Transporter
AN946_01585	ENOG4105D82	Glutamate dehydrogenase
AN946_01590	ENOG4105C8V	SAICAR synthetase
AN946_01595	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
AN946_01600	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
AN946_01610	ENOG4107RCW	fructose-bisphosphate aldolase
AN946_01625	ENOG4105M6F	mutator MutT protein
AN946_01660	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
AN946_01670	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
AN946_01685	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
AN946_01690	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
AN946_01710	ENOG4105KNI	merR family transcriptional Regulator
AN946_01715	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AN946_01720	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN946_01725	ENOG4105CFG	Acts as a chaperone (By similarity)
AN946_01730	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
AN946_01735	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
AN946_01760	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
AN946_01770	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
AN946_01785	ENOG4105QAX	Iron-sulfur
AN946_01810	ENOG4105DKQ	ROK family
AN946_01845	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
AN946_01865	ENOG4108UCS	ABC, transporter
AN946_01870	ENOG4105E0C	molybdate abc transporter
AN946_01875	ENOG4105DP9	ABC transporter
AN946_01900	ENOG4108JPZ	Monovalent cation H antiporter subunit D
AN946_01905	ENOG4105MKQ	Monovalent cation H antiporter subunit C
AN946_01915	ENOG4105DHP	deoxycytidine triphosphate deaminase
AN946_01925	ENOG4105IYK	transposase
AN946_01980	ENOG4105EKX	Restriction modification system DNA (Specificity
AN946_02025	ENOG4105C6E	dna polymerase iii
AN946_02030	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
AN946_02035	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
AN946_02050	ENOG4105VMP	Transcriptional regulator
AN946_02100	ENOG4105D74	hydrolase
AN946_02135	ENOG4105BZ4	penicillin-binding protein
AN946_02150	ENOG4108IUK	alpha amylase, catalytic
AN946_02160	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AN946_02170	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
AN946_02180	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
AN946_02230	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
AN946_02235	ENOG4105DPH	UPF0371 protein
AN946_02240	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
AN946_02250	ENOG4108Z6B	deaminase
AN946_02255	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
AN946_02280	ENOG4105CQC	Prephenate dehydratase
AN946_02290	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
AN946_02295	ENOG4108KP7	hydrolase
AN946_02330	ENOG4105D4B	ABC, transporter
AN946_02335	ENOG4105CNN	ABC, transporter
AN946_02365	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
AN946_02415	ENOG4105I1K	ABC transporter
AN946_02420	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
AN946_02435	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_02440	ENOG4108JJ8	(ABC) transporter
AN946_02445	ENOG4105BZ1	(ABC) transporter
AN946_02465	ENOG4105DQ5	transport system permease protein
AN946_02475	ENOG4105E0A	ABC, transporter
AN946_02485	ENOG4105DXX	methyltransferase
AN946_02490	ENOG4105D7K	pfkb domain protein
AN946_02495	ENOG4108UHU	Aldolase
AN946_02500	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
AN946_02505	ENOG4105DEI	Mannitol dehydrogenase
AN946_02510	ENOG4108FUF	Transcriptional regulator, IclR family
AN946_02515	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
AN946_02530	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
AN946_02535	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
AN946_02540	ENOG4105DSB	aldose 1-epimerase
AN946_02545	ENOG4105WH1	Two component transcriptional regulator luxr family
AN946_02555	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AN946_02565	ENOG4108M15	ABC transporter
AN946_02580	ENOG4108S01	response regulator
AN946_02585	ENOG4105CQ7	ATP-dependent helicase
AN946_02615	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
AN946_02620	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
AN946_02640	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AN946_02650	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
AN946_02655	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
AN946_02660	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
AN946_02675	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
AN946_02690	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AN946_02710	ENOG4105IDI	abc transporter atp-binding protein
AN946_02715	ENOG4105HZM	Fha domain containing protein
AN946_02735	ENOG4105D9P	serine threonine protein kinase
AN946_02745	ENOG4105ZJT	Cell division protein CrgA
AN946_02750	ENOG4107ZXI	Rhomboid family
AN946_02790	ENOG4105MP0	transposase
AN946_02835	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AN946_02840	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AN946_02850	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
AN946_02855	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
AN946_02860	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
AN946_02875	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
AN946_02880	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
AN946_02890	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
AN946_02895	ENOG4107QJE	Chromosome Partitioning Protein
AN946_02905	ENOG4105CPF	Cell wall formation (By similarity)
AN946_02910	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AN946_02915	ENOG4105C3M	thioredoxin reductase
AN946_02935	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
AN946_02955	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
AN946_02960	ENOG4107YH6	single-stranded DNA-binding protein
AN946_02965	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
AN946_02970	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
AN946_02990	ENOG4105CDU	Replicative dna helicase
AN946_02995	ENOG4107Y80	Major Facilitator superfamily
AN946_03005	ENOG4105CUZ	uba thif-type nad fad binding protein
AN946_03025	ENOG4105CV8	reductase
AN946_03065	ENOG4105ZMH	deoxynucleoside kinase
AN946_03075	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
AN946_03080	ENOG4105F44	Two component transcriptional regulator, winged helix family
AN946_03095	ENOG4107RBB	ABC transporter, permease
AN946_03125	ENOG4105CZN	Potassium uptake protein
AN946_03140	ENOG4105CQ7	ATP-dependent helicase
AN946_03180	ENOG4108UVJ	appr-1-p processing domain protein
AN946_03185	ENOG4105CEP	NADH dehydrogenase
AN946_03200	ENOG41061GT	Aldolase
AN946_03210	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
AN946_03220	ENOG4105D4B	ABC, transporter
AN946_03230	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
AN946_03265	ENOG4105C8P	)-transporter
AN946_03280	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
AN946_03285	ENOG4108JJB	ABC transporter
AN946_03350	ENOG4105DKQ	ROK family
AN946_03360	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AN946_03375	ENOG4108NZE	NAGC-like transcriptional regulator
AN946_03390	ENOG4106N3A	copper homeostasis protein cutc
AN946_03405	ENOG4105D2H	Uronic isomerase
AN946_03410	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
AN946_03420	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
AN946_03425	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
AN946_03430	ENOG4105CPQ	Dehydrogenase
AN946_03435	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
AN946_03440	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
AN946_03450	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AN946_03455	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
AN946_03460	ENOG4108MES	Periplasmic binding protein
AN946_03465	ENOG4105DHS	permease protein
AN946_03470	ENOG4105CM4	permease protein
AN946_03475	ENOG4108IPW	abc transporter atp-binding protein
AN946_03480	ENOG4105C26	Dehydrogenase
AN946_03485	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
AN946_03490	ENOG4105DH8	myo-inositol catabolism
AN946_03510	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AN946_03525	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
AN946_03535	ENOG4105CNN	ABC, transporter
AN946_03540	ENOG4105D4B	ABC, transporter
AN946_03545	ENOG4105ECY	inositol monophosphatase
AN946_03550	ENOG4105CXY	transporter
AN946_03560	ENOG4105CPQ	Dehydrogenase
AN946_03575	ENOG4108JJB	ABC transporter
AN946_03580	ENOG4105BZ1	(ABC) transporter
AN946_03625	ENOG4107T5V	SNARE associated Golgi
AN946_03630	ENOG4107QTF	adenylosuccinate lyase
AN946_03635	ENOG41082T9	Membrane
AN946_03640	ENOG4105CIH	Imidazole acetol-phosphate transaminase
AN946_03655	ENOG4105FF2	Type I DHQase
AN946_03665	ENOG4105CPC	Aldo Keto reductase
AN946_03670	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
AN946_03675	ENOG4105VE1	Phosphatidylcholine synthase
AN946_03690	ENOG4107RES	phosphoglycerol transferase I
AN946_03700	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
AN946_03705	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
AN946_03715	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
AN946_03735	ENOG4105EHG	Permease protein
AN946_03740	ENOG4105E0A	ABC, transporter
AN946_03790	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
AN946_03795	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
AN946_03800	ENOG4105BZU	Histidine kinase
AN946_03815	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
AN946_03820	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
AN946_03850	ENOG4105DT3	PTS system, galactitol-specific IIc component
AN946_03855	ENOG4107W7X	Aldolase
AN946_03865	ENOG4105CMT	Dihydroxyacetone kinase
AN946_03900	ENOG4105C8N	cysteinyl-tRNA synthetase
AN946_03920	ENOG4105C2W	permease
AN946_03940	ENOG4105D22	carbon starvation protein
AN946_03955	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
AN946_03960	ENOG4105CFH	Aspartokinase
AN946_03985	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
AN946_03990	ENOG4108JE9	extracellular solute-binding protein family 1
AN946_04000	ENOG4105CK5	oxidoreductase
AN946_04050	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
AN946_04065	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
AN946_04075	ENOG4105PDP	Short chain dehydrogenase
AN946_04085	ENOG4105BZU	Histidine kinase
AN946_04090	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AN946_04110	ENOG4105VEQ	Cold shock protein
AN946_04120	ENOG4105EIP	mannose-6-phosphate isomerase
AN946_04125	ENOG4105C7N	Xanthine uracil vitamin C permease
AN946_04130	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
AN946_04225	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
AN946_04240	ENOG4108HUF	Transporter
AN946_04245	ENOG4108U1V	ABC transporter, permease
AN946_04250	ENOG4108U1V	ABC transporter, permease
AN946_04255	ENOG4105E0A	ABC, transporter
AN946_04260	ENOG4105FDP	GntR family transcriptional regulator
AN946_04285	ENOG4105KDC	50s ribosomal protein l28
AN946_04290	ENOG4105W0E	50S ribosomal protein L33
AN946_04295	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AN946_04300	ENOG4105NRA	50s ribosomal protein l31 type b
AN946_04305	ENOG4108638	50S ribosomal protein L36
AN946_04320	ENOG4105VUC	UPF0237 protein
AN946_04325	ENOG4105CAG	UPF0210 protein
AN946_04335	ENOG4105ECB	domain protein
AN946_04350	ENOG4105CID	antiterminator
AN946_04360	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
AN946_04390	ENOG4105C5Y	PTS System
AN946_04395	ENOG41082BZ	phosphocarrier protein (HPr)
AN946_04415	ENOG41080R8	Conserved Protein
AN946_04420	ENOG4107QR9	Iron-sulfur cluster binding protein
AN946_04425	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
AN946_04430	ENOG4105DAA	L-lactate
AN946_04435	ENOG4105CRK	lysyL-tRNA synthetase
AN946_04455	ENOG4105C94	Transporter
AN946_04460	ENOG4107RNR	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity)
AN946_04475	ENOG4105DA5	(ABC) transporter
AN946_04510	ENOG4108RWI	nicotinamidase
AN946_04520	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
AN946_04525	ENOG4105F8V	Hydrolase, tatD family
AN946_04535	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
AN946_04540	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
AN946_04545	ENOG4105C5H	ABC transporter
AN946_04560	ENOG4108IUX	(ABC) transporter
AN946_04575	ENOG4108IG5	Transcriptional regulator
AN946_04585	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
AN946_04590	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
AN946_04600	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
AN946_04615	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
AN946_04665	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
AN946_04685	ENOG4105C26	Dehydrogenase
AN946_04690	ENOG4105CK7	Sodium proline symporter
AN946_04705	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
AN946_04710	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
AN946_04715	ENOG4105T1M	mycothiol conjugate amidase mca
AN946_04725	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AN946_04730	ENOG4105D7K	pfkb domain protein
AN946_04735	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
AN946_04745	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
AN946_04755	ENOG4108IUW	ABC transporter
AN946_04770	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
AN946_04775	ENOG4105CGY	Dna recombination protein
AN946_04780	ENOG4105C3G	gtp-binding protein
AN946_04805	ENOG4105CSH	Transporter
AN946_04810	ENOG4105CH2	amidohydrolase
AN946_04835	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
AN946_04850	ENOG4105CEU	Arginine dihydrolase
AN946_04855	ENOG4105DBV	ornithine carbamoyltransferase
AN946_04875	ENOG4105CSH	Transporter
AN946_04885	ENOG4108YYH	Nadph-dependent fmn reductase
AN946_04895	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
AN946_04925	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
AN946_04930	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AN946_04940	ENOG4105TMB	Formate nitrite transporter
AN946_04955	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
AN946_04965	ENOG4108JQ7	(ABC) transporter
AN946_04995	ENOG4105E2R	ROK family
AN946_05000	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
AN946_05005	ENOG4105DRS	transport system, permease
AN946_05015	ENOG4105CJQ	hydrolase, family 31
AN946_05020	ENOG4105CG3	alpha amylase, catalytic region
AN946_05030	ENOG4105CUC	YeeE YedE family protein
AN946_05035	ENOG4105E9K	Isocitrate dehydrogenase
AN946_05050	ENOG4105DFM	M18 family aminopeptidase
AN946_05060	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
AN946_05095	ENOG4105BZ1	(ABC) transporter
AN946_05105	ENOG4105CI3	gtp-binding protein typa
AN946_05120	ENOG4108Z4U	Ferredoxin
AN946_05140	ENOG4107WR6	Maf-like protein
AN946_05155	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AN946_05170	ENOG4108KGH	TRANSCRIPTIONal
AN946_05180	ENOG4107RGC	Glycosyl transferase, family 2
AN946_05190	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
AN946_05250	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
AN946_05310	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
AN946_05315	ENOG4105C09	Bile acid
AN946_05330	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
AN946_05370	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
AN946_05390	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AN946_05395	ENOG4105BZU	Histidine kinase
AN946_05400	ENOG4108T3R	lipoprotein lpqB
AN946_05405	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
AN946_05410	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
AN946_05420	ENOG4108VPT	UPF0234 protein
AN946_05440	ENOG4105WDJ	50S ribosomal protein L33
AN946_05455	ENOG4107R4N	Cell wall formation (By similarity)
AN946_05470	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
AN946_05495	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
AN946_05500	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
AN946_05505	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
AN946_05520	ENOG4105DBI	uridine monophosphokinase
AN946_05525	ENOG4108VZM	50s ribosomal protein L10
AN946_05530	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
AN946_05535	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AN946_05540	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AN946_05545	ENOG4108IQI	permease
AN946_05550	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
AN946_05555	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
AN946_05560	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
AN946_05565	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
AN946_05580	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
AN946_05585	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
AN946_05590	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
AN946_05595	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
AN946_05600	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN946_05605	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
AN946_05610	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
AN946_05615	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
AN946_05620	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
AN946_05630	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
AN946_05635	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
AN946_05640	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
AN946_05645	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN946_05650	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
AN946_05655	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
AN946_05660	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
AN946_05670	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
AN946_05675	ENOG4105VPB	50S ribosomal protein L30
AN946_05680	ENOG4107ZG5	Binds to the 23S rRNA (By similarity)
AN946_05690	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
AN946_05700	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
AN946_05705	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN946_05715	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
AN946_05720	ENOG4108ZT0	50S ribosomal protein l17
AN946_05735	ENOG4108JEH	abc transporter atp-binding protein
AN946_05740	ENOG4105E5Q	amino acid AbC transporter
AN946_05750	ENOG4105DFK	Polyphosphate glucokinase
AN946_05755	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
AN946_05775	ENOG4108JJB	ABC transporter
AN946_05780	ENOG4108V7D	UPF0397 protein
AN946_05790	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
AN946_05795	ENOG4108UJD	30S ribosomal protein S9
AN946_05805	ENOG4105CS9	pantothenic acid kinase
AN946_05810	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
AN946_05820	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
AN946_05825	ENOG4108097	ATP-binding protein
AN946_05855	ENOG4105E33	succinate dehydrogenase
AN946_05860	ENOG4105C8J	)-transporter
AN946_05865	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
AN946_05870	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
AN946_05880	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
AN946_05890	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
AN946_05895	ENOG4105C8V	SAICAR synthetase
AN946_05900	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
AN946_05905	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
AN946_05910	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
AN946_05915	ENOG4105C12	Phosphoribosylglycinamide synthetase
AN946_05920	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
AN946_05935	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
AN946_05945	ENOG4107QVP	Dehydrogenase
AN946_05950	ENOG4105C9Q	fumarate hydratase class II
AN946_05960	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AN946_05975	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
AN946_05980	ENOG4105C6K	Malic enzyme
AN946_05985	ENOG4105DR9	pseudouridine synthase
AN946_05990	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AN946_06010	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
AN946_06020	ENOG4105EXC	Acyl-transferase
AN946_06025	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
AN946_06055	ENOG4105CTQ	phosphohexokinase
AN946_06060	ENOG4107QP8	phosphohexose isomerase
AN946_06065	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
AN946_06070	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
AN946_06080	ENOG4108UW5	maltose o-acetyltransferase
AN946_06105	ENOG4105CEY	Amp-dependent synthetase and ligase
AN946_06115	ENOG4105C54	Major Facilitator superfamily
AN946_06120	ENOG4105C5X	domain protein
AN946_06135	ENOG4105C10	Electron transfer flavoprotein
AN946_06140	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
AN946_06160	ENOG4108JIK	carboxylase
AN946_06165	ENOG4105D8K	carboxyl transferase
AN946_06170	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
AN946_06180	ENOG4107ZYJ	bioY protein
AN946_06190	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
AN946_06195	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
AN946_06210	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
AN946_06215	ENOG4105DIH	basic membrane
AN946_06220	ENOG4108JQ9	ABC transporter
AN946_06250	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
AN946_06255	ENOG4105E5M	Multidrug resistance protein D
AN946_06265	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
AN946_06275	ENOG4108URH	decarboxylase
AN946_06295	ENOG4105CJW	magnesium transporter
AN946_06300	ENOG4107T6F	Xaa-Pro aminopeptidase
AN946_06310	ENOG41081FY	multiple antibiotic resistance (MarC)-related
AN946_06315	ENOG4105C1J	atp-dependent rna helicase
AN946_06330	ENOG4105C4R	Atp-dependent dna helicase
AN946_06375	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
AN946_06380	ENOG4105CAK	Cell division ATP-binding protein ftsE
AN946_06385	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
AN946_06390	ENOG4105DR5	peptidase
AN946_06395	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
AN946_06435	ENOG4108C33	Resolvase
AN946_06495	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AN946_06500	ENOG4105GVJ	transcriptional regulator
AN946_06540	ENOG4105C4K	Nad synthetase
AN946_06555	ENOG4107WGA	YidE YbjL
AN946_06560	ENOG4108426	dNA-binding protein
AN946_06580	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
AN946_06590	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
AN946_06600	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
AN946_06605	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
AN946_06635	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
AN946_06640	ENOG4105C87	Aminotransferase class I and II
AN946_06645	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
AN946_06655	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_06690	ENOG4105DGW	oligopeptidase A
AN946_06695	ENOG4105CSC	Glucose uptake protein
AN946_06705	ENOG4105JNK	Glycosyl transferase (Group 1
AN946_06715	ENOG4105DZW	Dipeptidase
AN946_06725	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
AN946_06730	ENOG4105CPF	Cell wall formation (By similarity)
AN946_06740	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
AN946_06750	ENOG4105VB9	50S ribosomal protein l28
AN946_06765	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
AN946_06780	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
AN946_06785	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
AN946_06795	ENOG4108JU3	Alkyl hydroperoxide reductase
AN946_06800	ENOG4105D3R	alkyl hydroperoxide reductase
AN946_06805	ENOG4105BZ1	(ABC) transporter
AN946_06810	ENOG4105BZ1	(ABC) transporter
AN946_06820	ENOG4108JJ8	(ABC) transporter
AN946_06830	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
AN946_06835	ENOG4105C4M	(Ubiquinol oxidase) subunit I
AN946_06840	ENOG4105C03	ribonuclease
AN946_06845	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
AN946_06850	ENOG4105K46	50S ribosomal protein l27
AN946_06855	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN946_06865	ENOG41080RH	Thioredoxin
AN946_06870	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
AN946_06880	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
AN946_06885	ENOG4105CVJ	phosphoglycerate mutase
AN946_06920	ENOG4105FB2	class II Aldolase
AN946_06925	ENOG4105EDR	glucose galactose transporter
AN946_06930	ENOG4105NWF	RbsD or FucU transport
AN946_06935	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_06940	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
AN946_06945	ENOG4107VMI	polysaccharide deacetylase
AN946_06985	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
AN946_07000	ENOG4105CFP	Peptidase U32
AN946_07005	ENOG4108UMN	azlc family
AN946_07015	ENOG4105C85	amino acid
AN946_07020	ENOG4105D01	(LipO)protein
AN946_07025	ENOG4108UMI	ABC transporter, permease
AN946_07035	ENOG4107GFK	fumarate
AN946_07040	ENOG4105C85	amino acid
AN946_07050	ENOG41067QW	Transcriptional regulator
AN946_07075	ENOG4105CC5	ABC transporter
AN946_07090	ENOG4107SIG	periplasmic solute binding protein
AN946_07110	ENOG4107104	thymidine kinase
AN946_07115	ENOG4107RPQ	ABC transporter
AN946_07120	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
AN946_07145	ENOG4105C8T	Leucyl-tRNA synthetase
AN946_07160	ENOG4105D7A	ATP-binding protein
AN946_07180	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AN946_07185	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
AN946_07190	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
AN946_07215	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
AN946_07220	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
AN946_07240	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
AN946_07245	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
AN946_07250	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
AN946_07260	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
AN946_07295	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
AN946_07300	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
AN946_07305	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
AN946_07310	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
AN946_07320	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
AN946_07330	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
AN946_07335	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
AN946_07345	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
AN946_07350	ENOG41084BS	50S ribosomal protein L35
AN946_07355	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
AN946_07365	ENOG4108RWN	rrna methyltransferase
AN946_07380	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
AN946_07385	ENOG4108Z66	YbaK ebsC protein
AN946_07390	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
AN946_07405	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
AN946_07410	ENOG4105CMR	udp-glucose 4-epimerase
AN946_07420	ENOG4105VZ8	Transcriptional regulator
AN946_07430	ENOG4108M15	ABC transporter
AN946_07435	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
AN946_07440	ENOG4107SIG	periplasmic solute binding protein
AN946_07445	ENOG4105DIK	(ABC) transporter
AN946_07450	ENOG4107RPQ	ABC transporter
AN946_07480	ENOG4105DSU	hydrolase
AN946_07490	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
AN946_07495	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
AN946_07545	ENOG4105C3K	feS assembly ATPase SufC
AN946_07560	ENOG4105VG1	fes assembly suf system protein
AN946_07565	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
AN946_07570	ENOG4105C5H	ABC transporter
AN946_07580	ENOG4105EAC	phosphoserine phosphatase
AN946_07590	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
AN946_07595	ENOG4107QPH	glycogen) synthase
AN946_07600	ENOG4105DKW	ABC transporter
AN946_07630	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
AN946_07635	ENOG4108V1U	phospholipid-binding protein
AN946_07650	ENOG4105C0B	DNA polymerase III (alpha subunit)
AN946_07675	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AN946_07685	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
AN946_07700	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
AN946_07705	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
AN946_07720	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
AN946_07725	ENOG4105E5F	proteasome
AN946_07730	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
AN946_07735	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
AN946_07750	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
AN946_07755	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
AN946_07760	ENOG4105DK0	Indole-3-glycerol phosphate synthase
AN946_07765	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
AN946_07770	ENOG4105CA9	Pyruvate kinase
AN946_07795	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
AN946_07820	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
AN946_07825	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
AN946_07835	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
AN946_07845	ENOG4105DHU	Bile acid
AN946_07855	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
AN946_07860	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
AN946_07865	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
AN946_07875	ENOG4105CIE	May be required for sporulation (By similarity)
AN946_07880	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
AN946_07885	ENOG4105BZA	Phosphoglycerate kinase
AN946_07890	ENOG4105CP7	Triose-phosphate isomerase
AN946_07910	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
AN946_07930	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
AN946_07935	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
AN946_07950	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
AN946_07955	ENOG4105CTQ	phosphohexokinase
AN946_08000	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
AN946_08010	ENOG4105CQR	helicase
AN946_08040	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
AN946_08045	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
AN946_08050	ENOG4107XKF	NMT1 THI5 Like Domain Protein
AN946_08055	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
AN946_08060	ENOG4105DJV	ribulose-phosphate 3-epimerase
AN946_08070	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
AN946_08075	ENOG4107RSZ	Primosomal protein n'
AN946_08080	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AN946_08090	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
AN946_08095	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
AN946_08110	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
AN946_08120	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
AN946_08130	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
AN946_08135	ENOG4105D49	3-dehydroquinate synthase
AN946_08140	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
AN946_08160	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
AN946_08165	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
AN946_08175	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
AN946_08185	ENOG4107R13	MMPL domain protein
AN946_08200	ENOG4105C9M	aspartyl-trna synthetase
AN946_08220	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AN946_08225	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
AN946_08230	ENOG4105CUT	histidyl-tRNA synthetase
AN946_08235	ENOG4105C5X	domain protein
AN946_08240	ENOG4105C99	atpase involved in dna repair
AN946_08260	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
AN946_08265	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
AN946_08270	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AN946_08275	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
AN946_08285	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
AN946_08290	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
AN946_08295	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
AN946_08300	ENOG4105CDY	transcriptional regulatory protein
AN946_08305	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
AN946_08315	ENOG4105E2K	Glycosyl transferase (Group 1
AN946_08330	ENOG4105C22	threonyL-tRNA synthetase
AN946_08335	ENOG4105EJQ	L-serine dehydratase
AN946_08340	ENOG4105WH1	Two component transcriptional regulator luxr family
AN946_08415	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
AN946_08425	ENOG4107QM5	aconitate hydratase
AN946_08430	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
AN946_08440	ENOG4107VEG	TrkA-N domain protein
AN946_08485	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AN946_08500	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
AN946_08510	ENOG4105DVT	helicase
AN946_08550	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
AN946_08555	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
AN946_08595	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
AN946_08610	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
AN946_08645	ENOG4105C5F	glutamine synthetase
AN946_08655	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
AN946_08660	ENOG4105C5F	glutamine synthetase
AN946_08675	ENOG4105DFK	Polyphosphate glucokinase
AN946_08680	ENOG4105D1Q	UPF0246 protein
AN946_08690	ENOG4105EGD	dinuclear metal center protein, YbgI family
AN946_08700	ENOG4108680	CrcB-like protein
AN946_08725	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
AN946_08745	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
AN946_08765	ENOG4105ECP	epimerase
AN946_08770	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
AN946_08800	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
AN946_08805	ENOG4105EHG	Permease protein
AN946_08845	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
AN946_08850	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
AN946_08860	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
AN946_08865	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
AN946_08885	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
AN946_08895	ENOG4105DIK	(ABC) transporter
AN946_08900	ENOG4105CC5	ABC transporter
AN946_08905	ENOG41090R7	Ferric uptake
AN946_08920	ENOG4105C0B	DNA polymerase III (alpha subunit)
AN946_08950	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
AN946_08960	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
AN946_08970	ENOG4105DFU	Cell wall formation (By similarity)
AN946_08975	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
AN946_08980	ENOG4105CNI	cell division protein FtsW
AN946_08985	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
AN946_08990	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
AN946_09000	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
AN946_09005	ENOG4105CJN	penicillin-binding protein
AN946_09015	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
AN946_09020	ENOG4108V6E	Cell division protein mraZ
AN946_09030	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
AN946_09050	ENOG4108JQ1	Dehydrogenase
AN946_09060	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
AN946_09070	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
AN946_09085	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
AN946_09090	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
AN946_09095	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
AN946_09105	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
AN946_09115	ENOG4105WBV	Transcriptional regulator
AN946_09135	ENOG4107QZI	cell division protein FtsK
AN946_09140	ENOG4105CN5	Metallo-Beta-Lactamase
AN946_09160	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
AN946_09165	ENOG4105C1V	Peptidase, M16
AN946_09175	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
AN946_09180	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
AN946_09230	ENOG4105CXY	transporter
AN946_09235	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
AN946_09240	ENOG4105BZU	Histidine kinase
AN946_09245	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
AN946_09250	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
AN946_09255	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
AN946_09270	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
AN946_09280	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
AN946_09290	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
AN946_09295	ENOG4105DZP	Membrane-associated zinc metalloprotease
AN946_09300	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
AN946_09310	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
AN946_09320	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
AN946_09325	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
AN946_09345	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
AN946_09350	ENOG4105C10	Electron transfer flavoprotein
AN946_09360	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
AN946_09365	ENOG4105CE9	30S ribosomal protein S2
AN946_09370	ENOG4105EN6	Membrane
AN946_09375	ENOG4108K5P	(LipO)protein
AN946_09380	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AN946_09390	ENOG4105C0P	Mg chelatase subunit ChlI
AN946_09405	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
AN946_09410	ENOG4107QYR	Signal peptidase i
AN946_09415	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
AN946_09420	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
AN946_09425	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
AN946_09430	ENOG41082KU	UPF0109 protein
AN946_09435	ENOG4105K5M	30s ribosomal protein S16
AN946_09460	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
AN946_09465	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
AN946_09480	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
AN946_09485	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
AN946_09490	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
AN946_09525	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
AN946_09530	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
AN946_09535	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AN946_09540	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
AN946_09545	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
AN946_09550	ENOG4105CPC	Aldo Keto reductase
AN946_09560	ENOG4105D17	glycoside hydrolase, family 3 domain protein
AN946_09565	ENOG4105CT4	transporter
AN946_09570	ENOG4105CNT	hydrolase family 2
AN946_09575	ENOG4105ETE	Transcriptional regulator (LacI family
AN946_09585	ENOG4105C5H	ABC transporter
AN946_09610	ENOG4105XSJ	toxin secretion phage lysis holin
AN946_09690	ENOG4105EFC	phage portal protein HK97 family
AN946_09700	ENOG4105CAR	Terminase, large subunit
AN946_09730	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
AN946_09775	ENOG4105WXW	Antirepressor
AN946_09785	ENOG4105C2M	dna polymerase I
AN946_09845	ENOG4105DZR	Type I site-specific deoxyribonuclease
AN946_09875	ENOG4107QN2	dihydrolipoyl dehydrogenase
AN946_09890	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
AN946_09900	ENOG4105D7W	serine acetyltransferase
AN946_09915	ENOG4105C9K	Endothelin-converting enzyme 1
AN946_09920	ENOG4105CKW	Inner membrane protein yedI
AN946_09930	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
AN946_09945	ENOG4105C29	acyl-CoA thioesterase
AN946_09975	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
AN946_10095	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
AN946_10115	ENOG4108XUD	Membrane
AN946_10145	ENOG4105KPE	licD family
AN946_10155	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
AN946_10170	ENOG4105DFA	alanine racemase domain protein
AN946_10185	ENOG4105C6N	Formate acetyltransferase
AN946_10190	ENOG4105CM2	brancheD-chain amino acid aminotransferase
AN946_10205	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
AN946_10210	ENOG4108ZP8	Acetolactate synthase small subunit
AN946_10220	ENOG4105D0C	transport protein
AN946_10225	ENOG4105C01	Dihydroxy-acid dehydratase