locus-tag	class	description
AN946_00010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN946_00015	COG0154	amidase activity
AN946_00020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN946_00025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN946_00040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_00050	COG1397	ADP-ribosylglycohydrolase
AN946_00055	COG2188	Transcriptional regulator
AN946_00060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN946_00065	COG2135	peptidase activity
AN946_00105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN946_00130	COG1053	succinate dehydrogenase
AN946_00140	COG0387	Pfam Sodium calcium exchanger
AN946_00150	COG1131	(ABC) transporter
AN946_00155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_00180	COG1615	UPF0182 protein
AN946_00220	COG0180	Tryptophanyl-tRNA synthetase
AN946_00225	COG0058	SHG alpha-glucan phosphorylase activity
AN946_00255	COG0366	Alpha amylase catalytic
AN946_00260	COG0366	Alpha amylase catalytic
AN946_00265	COG3281	Trehalose synthase
AN946_00270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AN946_00280	COG3833	ABC-type maltose transport systems, permease component
AN946_00295	COG1609	Transcriptional regulator
AN946_00340	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AN946_00355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN946_00360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN946_00365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN946_00370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN946_00375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN946_00380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN946_00385	COG0356	it plays a direct role in the translocation of protons across the membrane
AN946_00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN946_00425	COG0083	homoserine kinase activity
AN946_00430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN946_00435	COG0460	homoserine dehydrogenase
AN946_00445	COG0018	arginyl-trna synthetase
AN946_00485	COG0584	glycerophosphoryl diester phosphodiesterase
AN946_00500	COG1253	flavin adenine dinucleotide binding
AN946_00505	COG0567	Dehydrogenase, E1 component
AN946_00505	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN946_00515	COG3103	Sh3 type 3 domain protein
AN946_00515	COG1388	LysM domain
AN946_00515	COG0791	NLP P60 protein
AN946_00530	COG1595	DNA-templated transcription, initiation
AN946_00540	COG0363	glucosamine-6-phosphate deaminase activity
AN946_00545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AN946_00555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN946_00560	COG4608	Belongs to the ABC transporter superfamily
AN946_00565	COG0444	Belongs to the ABC transporter superfamily
AN946_00610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN946_00615	COG1162	GTPase activity
AN946_00620	COG0483	inositol monophosphate 1-phosphatase activity
AN946_00625	COG0420	3'-5' exonuclease activity
AN946_00630	COG0419	ATPase involved in DNA repair
AN946_00670	COG0653	protein targeting
AN946_00680	COG1007	ATP synthesis coupled electron transport
AN946_00690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN946_00695	COG0713	ATP synthesis coupled electron transport
AN946_00700	COG0839	Belongs to the complex I subunit 6 family
AN946_00705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_00710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AN946_00715	COG1034	ATP synthesis coupled electron transport
AN946_00720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN946_00730	COG0649	NAD binding
AN946_00735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_00740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_00750	COG0644	oxidoreductase
AN946_00755	COG2226	methyltransferase
AN946_00760	COG1169	isochorismate synthase
AN946_00775	COG4948	Mandelate Racemase Muconate Lactonizing
AN946_00780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AN946_00790	COG1175	transmembrane transport
AN946_00795	COG0395	ABC-type sugar transport system, permease component
AN946_00820	COG0406	alpha-ribazole phosphatase activity
AN946_00825	COG1846	Transcriptional regulator
AN946_00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN946_00840	COG0569	domain protein
AN946_00845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AN946_00855	COG1194	a g-specific adenine glycosylase
AN946_00870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN946_00875	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AN946_00880	COG0247	lactate metabolic process
AN946_00885	COG3386	PFAM SMP-30 Gluconolaconase
AN946_00895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN946_00900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN946_00905	COG2409	Drug exporters of the RND superfamily
AN946_00910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AN946_00920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AN946_00925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN946_00935	COG2376	Dihydroxyacetone kinase
AN946_00940	COG1461	Dihydroxyacetone kinase
AN946_00955	COG3250	beta-galactosidase activity
AN946_00975	COG1609	Transcriptional regulator
AN946_01005	COG0302	gtp cyclohydrolase
AN946_01010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN946_01020	COG0037	tRNA processing
AN946_01035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN946_01045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN946_01050	COG2267	carboxylic ester hydrolase activity
AN946_01060	COG0277	FAD linked oxidase domain protein
AN946_01060	COG0247	lactate metabolic process
AN946_01065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN946_01065	COG0574	Belongs to the PEP-utilizing enzyme family
AN946_01080	COG1175	transmembrane transport
AN946_01085	COG0395	ABC-type sugar transport system, permease component
AN946_01090	COG0366	Alpha amylase catalytic
AN946_01110	COG5290	Psort location Cytoplasmic, score
AN946_01135	COG1285	pathogenesis
AN946_01140	COG2271	Major facilitator Superfamily
AN946_01160	COG0737	Belongs to the 5'-nucleotidase family
AN946_01175	COG1116	anion transmembrane transporter activity
AN946_01180	COG2226	methyltransferase
AN946_01185	COG1609	Transcriptional regulator
AN946_01190	COG1129	ABC transporter
AN946_01195	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_01200	COG1879	ABC-type sugar transport system periplasmic component
AN946_01205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_01210	COG1869	D-ribose catabolic process
AN946_01240	COG2610	gluconate transmembrane transporter activity
AN946_01245	COG1609	Transcriptional regulator
AN946_01255	COG3250	beta-galactosidase activity
AN946_01275	COG3119	arylsulfatase activity
AN946_01280	COG1609	Transcriptional regulator
AN946_01285	COG2814	Major facilitator Superfamily
AN946_01290	COG0641	radical SAM
AN946_01295	COG0730	response to heat
AN946_01300	COG0698	ribose 5-phosphate isomerase
AN946_01310	COG2376	Dihydroxyacetone kinase
AN946_01315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN946_01325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN946_01340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AN946_01365	COG2390	Transcriptional regulator
AN946_01370	COG0738	Major facilitator superfamily
AN946_01380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_01385	COG0542	response to heat
AN946_01390	COG1490	D-aminoacyl-tRNA deacylase activity
AN946_01400	COG0354	folic acid binding
AN946_01405	COG3485	protocatechuate 3,4-dioxygenase
AN946_01415	COG0737	Belongs to the 5'-nucleotidase family
AN946_01425	COG1115	amino acid carrier protein
AN946_01435	COG0306	phosphate transporter
AN946_01440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN946_01465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN946_01495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN946_01525	COG0039	L-malate dehydrogenase activity
AN946_01555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN946_01585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN946_01590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN946_01595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AN946_01600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN946_01610	COG0191	fructose-bisphosphate aldolase activity
AN946_01625	COG0494	nUDIX hydrolase
AN946_01670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN946_01685	COG1506	peptidase
AN946_01685	COG0823	Involved in the tonB-independent uptake of proteins
AN946_01690	COG0584	glycerophosphoryl diester phosphodiesterase
AN946_01710	COG0789	Transcriptional regulator
AN946_01715	COG0484	heat shock protein binding
AN946_01720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN946_01725	COG0443	Heat shock 70 kDa protein
AN946_01730	COG0167	dihydroorotate dehydrogenase activity
AN946_01735	COG0167	dihydroorotate dehydrogenase activity
AN946_01760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AN946_01770	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN946_01785	COG0437	4 iron, 4 sulfur cluster binding
AN946_01795	COG1505	serine-type exopeptidase activity
AN946_01810	COG1940	carbohydrate kinase activity
AN946_01845	COG0662	Cupin 2, conserved barrel domain protein
AN946_01865	COG3842	ATPase activity
AN946_01870	COG4149	molybdate abc transporter
AN946_01875	COG4143	(ABC) transporter
AN946_01915	COG0717	Belongs to the dCTP deaminase family
AN946_01925	COG2963	transposase activity
AN946_01980	COG0732	type I restriction modification DNA specificity domain
AN946_02025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN946_02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN946_02035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN946_02035	COG1754	DNA topoisomerase type I activity
AN946_02050	COG3655	Transcriptional regulator
AN946_02100	COG2267	carboxylic ester hydrolase activity
AN946_02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN946_02160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN946_02170	COG0315	cyclic pyranopterin monophosphate synthase activity
AN946_02180	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN946_02230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN946_02235	COG4868	Belongs to the UPF0371 family
AN946_02250	COG0590	tRNA wobble adenosine to inosine editing
AN946_02255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN946_02280	COG0077	Prephenate dehydratase
AN946_02290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN946_02295	COG0561	phosphatase activity
AN946_02330	COG1879	ABC-type sugar transport system periplasmic component
AN946_02335	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_02365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AN946_02380	COG1487	ribonuclease activity
AN946_02435	COG1609	Transcriptional regulator
AN946_02440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN946_02445	COG1132	(ABC) transporter
AN946_02465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_02475	COG1120	ATPase activity
AN946_02485	COG2226	methyltransferase
AN946_02490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_02495	COG0800	Aldolase
AN946_02500	COG1312	Catalyzes the dehydration of D-mannonate
AN946_02505	COG0246	Mannitol dehydrogenase
AN946_02510	COG1414	Transcriptional regulator
AN946_02515	COG0577	efflux transmembrane transporter activity
AN946_02515	COG1136	(ABC) transporter
AN946_02535	COG1328	CTP reductase activity
AN946_02545	COG2197	response regulator
AN946_02555	COG1136	(ABC) transporter
AN946_02565	COG1131	(ABC) transporter
AN946_02580	COG2197	response regulator
AN946_02585	COG1643	Atp-dependent helicase
AN946_02615	COG1175	transmembrane transport
AN946_02620	COG0395	ABC-type sugar transport system, permease component
AN946_02640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN946_02650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN946_02655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN946_02660	COG1780	Probably involved in ribonucleotide reductase function
AN946_02675	COG1854	S-ribosylhomocysteine lyase activity
AN946_02710	COG1131	(ABC) transporter
AN946_02710	COG1716	ATPase activity
AN946_02710	COG0842	Transport permease protein
AN946_02715	COG1716	ATPase activity
AN946_02750	COG0705	Rhomboid family
AN946_02750	COG0457	Tetratricopeptide repeat
AN946_02835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN946_02840	COG0187	DNA topoisomerase II activity
AN946_02850	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN946_02855	COG0592	DNA-directed DNA polymerase activity
AN946_02860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN946_02865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN946_02870	COG0594	ribonuclease P activity
AN946_02875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN946_02880	COG0706	membrane insertase activity
AN946_02890	COG0357	Ribosomal RNA small subunit methyltransferase G
AN946_02895	COG1192	Involved in chromosome partitioning
AN946_02905	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN946_02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_02935	COG0617	tRNA 3'-terminal CCA addition
AN946_02955	COG0360	Binds together with S18 to 16S ribosomal RNA
AN946_02965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN946_02970	COG0359	binds to the 23S rRNA
AN946_02990	COG0305	Participates in initiation and elongation during chromosome replication
AN946_02995	COG2814	Major facilitator Superfamily
AN946_03005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN946_03065	COG1428	Deoxynucleoside kinase
AN946_03075	COG0343	queuine tRNA-ribosyltransferase activity
AN946_03080	COG0745	RESPONSE REGULATOR receiver
AN946_03095	COG0577	efflux transmembrane transporter activity
AN946_03125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN946_03140	COG1643	Atp-dependent helicase
AN946_03180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN946_03185	COG1252	NADH dehydrogenase
AN946_03210	COG1070	Carbohydrate kinase
AN946_03220	COG1879	ABC-type sugar transport system periplasmic component
AN946_03230	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_03265	COG0471	metal ion transport
AN946_03280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AN946_03285	COG1129	ABC transporter
AN946_03325	COG1175	transmembrane transport
AN946_03350	COG1940	carbohydrate kinase activity
AN946_03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN946_03365	COG0601	transmembrane transport
AN946_03375	COG1940	carbohydrate kinase activity
AN946_03390	COG3142	Participates in the control of copper homeostasis
AN946_03405	COG1904	glucuronate isomerase
AN946_03410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN946_03425	COG0156	8-amino-7-oxononanoate synthase activity
AN946_03430	COG1063	alcohol dehydrogenase
AN946_03435	COG0395	ABC-type sugar transport system, permease component
AN946_03440	COG1175	transmembrane transport
AN946_03450	COG0673	inositol 2-dehydrogenase activity
AN946_03455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AN946_03460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN946_03465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_03470	COG4605	iron ion homeostasis
AN946_03475	COG4604	ABC transporter, ATP-binding protein
AN946_03485	COG3962	Belongs to the TPP enzyme family
AN946_03490	COG3718	enzyme involved in inositol metabolism
AN946_03510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN946_03515	COG0673	inositol 2-dehydrogenase activity
AN946_03525	COG0673	inositol 2-dehydrogenase activity
AN946_03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_03540	COG1879	ABC-type sugar transport system periplasmic component
AN946_03545	COG0483	inositol monophosphate 1-phosphatase activity
AN946_03550	COG2271	Major facilitator Superfamily
AN946_03560	COG1063	alcohol dehydrogenase
AN946_03575	COG1129	ABC transporter
AN946_03580	COG1132	(ABC) transporter
AN946_03590	COG1309	transcriptional regulator
AN946_03625	COG0586	Pfam SNARE associated Golgi protein
AN946_03630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN946_03635	COG1950	PFAM Membrane protein of
AN946_03640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN946_03655	COG0710	3-dehydroquinate dehydratase activity
AN946_03665	COG0667	Aldo Keto reductase
AN946_03670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN946_03700	COG1175	transmembrane transport
AN946_03705	COG0395	ABC-type sugar transport system, permease component
AN946_03715	COG3345	alpha-galactosidase
AN946_03735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_03740	COG1120	ATPase activity
AN946_03790	COG0588	phosphoglycerate mutase activity
AN946_03795	COG0704	Plays a role in the regulation of phosphate uptake
AN946_03800	COG5002	protein histidine kinase activity
AN946_03815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN946_03820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN946_03850	COG3775	system Galactitol-specific IIC component
AN946_03855	COG0235	Class ii aldolase
AN946_03865	COG2376	Dihydroxyacetone kinase
AN946_03900	COG0215	cysteine-tRNA ligase activity
AN946_03905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN946_03920	COG2233	PERMEase
AN946_03940	COG1966	Carbon starvation protein
AN946_03955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN946_03990	COG1653	transport
AN946_04000	COG0673	inositol 2-dehydrogenase activity
AN946_04050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN946_04065	COG0459	protein refolding
AN946_04075	COG4221	oxidoreductase activity
AN946_04085	COG2205	protein histidine kinase activity
AN946_04090	COG0745	RESPONSE REGULATOR receiver
AN946_04100	COG1842	Phage shock protein A
AN946_04110	COG1278	Cold shock
AN946_04125	COG2252	PERMEase
AN946_04130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN946_04225	COG0596	Alpha beta hydrolase
AN946_04240	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AN946_04245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_04255	COG1120	ATPase activity
AN946_04260	COG2188	Transcriptional regulator
AN946_04265	COG2267	carboxylic ester hydrolase activity
AN946_04270	COG0477	Major facilitator Superfamily
AN946_04285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN946_04290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN946_04295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN946_04300	COG0254	rRNA binding
AN946_04305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN946_04320	COG3830	Belongs to the UPF0237 family
AN946_04325	COG2848	UPF0210 protein
AN946_04335	COG1511	domain protein
AN946_04350	COG3711	transcriptional antiterminator
AN946_04360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN946_04370	COG1051	belongs to the nudix hydrolase family
AN946_04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN946_04385	COG1263	PTS System
AN946_04390	COG2190	(PTS) system
AN946_04395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN946_04415	COG1556	Lactate utilization protein
AN946_04425	COG0247	lactate metabolic process
AN946_04430	COG1620	l-lactate permease
AN946_04455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN946_04460	COG2813	Specifically methylates the guanine in position
AN946_04475	COG1131	(ABC) transporter
AN946_04510	COG1335	isochorismatase
AN946_04520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN946_04525	COG0084	hydrolase, TatD family'
AN946_04535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN946_04540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN946_04545	COG0488	(ABC) transporter
AN946_04560	COG4152	abc transporter atp-binding protein
AN946_04575	COG1309	transcriptional regulator
AN946_04585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN946_04595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN946_04600	COG0193	aminoacyl-tRNA hydrolase activity
AN946_04615	COG0148	phosphopyruvate hydratase activity
AN946_04665	COG1725	Transcriptional regulator
AN946_04685	COG1012	belongs to the aldehyde dehydrogenase family
AN946_04690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN946_04705	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN946_04710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN946_04715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AN946_04725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN946_04730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_04735	COG1722	exodeoxyribonuclease VII activity
AN946_04745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN946_04755	COG4555	ABC transporter
AN946_04770	COG1162	GTPase activity
AN946_04775	COG1322	Protein conserved in bacteria
AN946_04780	COG0012	GTP binding
AN946_04805	COG0477	Major facilitator Superfamily
AN946_04810	COG1473	amidohydrolase
AN946_04825	COG1653	transport
AN946_04835	COG0395	ABC-type sugar transport system, permease component
AN946_04850	COG2235	arginine
AN946_04855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AN946_04860	COG0549	Belongs to the carbamate kinase family
AN946_04865	COG1834	amidinotransferase
AN946_04875	COG0477	Major facilitator Superfamily
AN946_04885	COG0431	NADPH-dependent FMN reductase
AN946_04895	COG1780	Probably involved in ribonucleotide reductase function
AN946_04925	COG1970	mechanosensitive ion channel activity
AN946_04930	COG0242	peptide deformylase activity
AN946_04940	COG2116	formate transmembrane transporter activity
AN946_04960	COG0444	Belongs to the ABC transporter superfamily
AN946_04965	COG4608	Belongs to the ABC transporter superfamily
AN946_04995	COG1940	carbohydrate kinase activity
AN946_04995	COG1846	Transcriptional regulator
AN946_05000	COG1175	transmembrane transport
AN946_05005	COG0395	ABC-type sugar transport system, permease component
AN946_05015	COG1501	Belongs to the glycosyl hydrolase 31 family
AN946_05025	COG0425	Belongs to the sulfur carrier protein TusA family
AN946_05030	COG2391	methyltransferase activity
AN946_05035	COG2838	Isocitrate dehydrogenase
AN946_05050	COG1362	aminopeptidase activity
AN946_05060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN946_05095	COG1132	(ABC) transporter
AN946_05140	COG0424	maF-like protein
AN946_05155	COG0745	RESPONSE REGULATOR receiver
AN946_05160	COG0642	Histidine kinase
AN946_05170	COG1316	TRANSCRIPTIONal
AN946_05190	COG1088	dTDP-glucose 4,6-dehydratase activity
AN946_05215	COG0673	inositol 2-dehydrogenase activity
AN946_05310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AN946_05370	COG0714	Associated with various cellular activities
AN946_05390	COG0745	RESPONSE REGULATOR receiver
AN946_05395	COG5002	protein histidine kinase activity
AN946_05395	COG5000	phosphorelay sensor kinase activity
AN946_05400	COG5401	PFAM Sporulation and spore germination
AN946_05405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN946_05410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN946_05420	COG1666	GTP binding
AN946_05440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN946_05455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN946_05470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN946_05480	COG0436	Aminotransferase
AN946_05495	COG0250	Participates in transcription elongation, termination and antitermination
AN946_05500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN946_05505	COG0081	regulation of translation
AN946_05520	COG0572	uridine kinase
AN946_05525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN946_05530	COG0222	ribosome binding
AN946_05535	COG0085	RNA polymerase activity
AN946_05540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN946_05545	COG0833	amino acid
AN946_05550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN946_05555	COG0049	tRNA binding
AN946_05560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN946_05565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN946_05580	COG0051	transcription antitermination factor activity, RNA binding
AN946_05585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN946_05590	COG0088	Forms part of the polypeptide exit tunnel
AN946_05595	COG0089	rRNA binding
AN946_05600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN946_05605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN946_05610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN946_05615	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN946_05620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN946_05630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AN946_05635	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN946_05640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN946_05645	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN946_05650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN946_05655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN946_05660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN946_05670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AN946_05675	COG1841	ribosomal large subunit assembly
AN946_05680	COG0200	Binds to the 23S rRNA
AN946_05690	COG0563	adenylate kinase activity
AN946_05700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN946_05705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN946_05715	COG0202	RNA polymerase activity
AN946_05720	COG0203	ribosomal protein L17
AN946_05735	COG4598	ABC transporter
AN946_05740	COG0765	amino acid transport
AN946_05750	COG1940	carbohydrate kinase activity
AN946_05755	COG0101	tRNA pseudouridine synthase activity
AN946_05775	COG1122	ATPase activity
AN946_05780	COG4720	Psort location CytoplasmicMembrane, score
AN946_05790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN946_05795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN946_05805	COG1072	(Pantothenic acid kinase))
AN946_05810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN946_05820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN946_05825	COG0802	atpase or kinase
AN946_05850	COG1053	succinate dehydrogenase
AN946_05855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN946_05860	COG0733	neurotransmitter:sodium symporter activity
AN946_05865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN946_05870	COG0428	transporter
AN946_05880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN946_05890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AN946_05895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN946_05900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN946_05905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN946_05910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN946_05915	COG0151	Belongs to the GarS family
AN946_05920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN946_05945	COG0516	GMP reductase activity
AN946_05950	COG0114	fumarate hydratase activity
AN946_05960	COG1136	(ABC) transporter
AN946_05975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN946_05980	COG0280	phosphate acetyltransferase
AN946_05980	COG0857	belongs to the CobB CobQ family
AN946_06010	COG0653	protein targeting
AN946_06020	COG2755	lipolytic protein G-D-S-L family
AN946_06020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AN946_06025	COG0045	succinate-CoA ligase (ADP-forming) activity
AN946_06055	COG0205	6-phosphofructokinase activity
AN946_06060	COG0166	Belongs to the GPI family
AN946_06070	COG0039	L-malate dehydrogenase activity
AN946_06080	COG0110	maltose O-acetyltransferase activity
AN946_06115	COG2271	Major facilitator Superfamily
AN946_06120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN946_06135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN946_06140	COG0644	oxidoreductase
AN946_06160	COG4770	biotin carboxylase activity
AN946_06165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN946_06170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN946_06180	COG1268	BioY protein
AN946_06190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN946_06195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN946_06210	COG0662	Cupin 2, conserved barrel domain protein
AN946_06210	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AN946_06250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AN946_06255	COG2814	Major facilitator Superfamily
AN946_06265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN946_06275	COG1611	Belongs to the LOG family
AN946_06295	COG2239	Acts as a magnesium transporter
AN946_06300	COG0006	proline dipeptidase activity
AN946_06310	COG2095	MarC family integral membrane protein
AN946_06315	COG0513	Belongs to the DEAD box helicase family
AN946_06330	COG0210	DNA helicase
AN946_06375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN946_06380	COG2884	Cell division ATP-binding protein ftsE
AN946_06385	COG2177	Part of the ABC transporter FtsEX involved in
AN946_06390	COG0739	heme binding
AN946_06405	COG1619	proteins homologs of microcin C7 resistance protein MccF
AN946_06435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AN946_06500	COG1846	Transcriptional regulator
AN946_06540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN946_06555	COG0569	domain protein
AN946_06555	COG2985	domain, Protein
AN946_06580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN946_06590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN946_06600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AN946_06605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AN946_06635	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN946_06640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AN946_06690	COG0339	signal peptide processing
AN946_06695	COG4975	Glucose uptake
AN946_06705	COG0438	transferase activity, transferring glycosyl groups
AN946_06725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN946_06730	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN946_06740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN946_06750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN946_06765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN946_06780	COG0571	ribonuclease III activity
AN946_06785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN946_06800	COG0450	alkyl hydroperoxide reductase
AN946_06805	COG1132	(ABC) transporter
AN946_06810	COG1132	(ABC) transporter
AN946_06820	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN946_06830	COG1294	oxidase, subunit
AN946_06835	COG1271	oxidase subunit
AN946_06840	COG1530	ribonuclease E activity
AN946_06845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN946_06850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AN946_06855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN946_06865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN946_06870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN946_06880	COG0799	negative regulation of ribosome biogenesis
AN946_06885	COG0406	alpha-ribazole phosphatase activity
AN946_06920	COG0235	Class ii aldolase
AN946_06925	COG0738	Major facilitator superfamily
AN946_06935	COG1609	Transcriptional regulator
AN946_06940	COG0133	tryptophan synthase activity
AN946_06945	COG0726	polysaccharide deacetylase
AN946_06985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_07005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN946_07015	COG1113	amino acid transport
AN946_07020	COG1464	Belongs to the NlpA lipoprotein family
AN946_07025	COG2011	ABC-type metal ion transport system permease component
AN946_07035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN946_07035	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AN946_07040	COG1113	amino acid transport
AN946_07050	COG1395	domain, Protein
AN946_07075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_07080	COG1121	(ABC) transporter
AN946_07090	COG0803	Belongs to the bacterial solute-binding protein 9 family
AN946_07110	COG1435	thymidine kinase activity
AN946_07120	COG0813	purine-nucleoside phosphorylase activity
AN946_07145	COG0495	leucyl-tRNA aminoacylation
AN946_07160	COG0433	COG0433 Predicted ATPase
AN946_07180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN946_07185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN946_07190	COG0268	Binds directly to 16S ribosomal RNA
AN946_07215	COG0481	GTPase activity
AN946_07220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN946_07240	COG1420	regulation of RNA biosynthetic process
AN946_07245	COG0484	heat shock protein binding
AN946_07250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN946_07260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN946_07295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN946_07300	COG1381	Involved in DNA repair and RecF pathway recombination
AN946_07305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN946_07310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN946_07320	COG0131	Imidazoleglycerol-phosphate dehydratase
AN946_07330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN946_07335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN946_07345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AN946_07350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN946_07365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN946_07385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN946_07390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN946_07405	COG1438	arginine binding
AN946_07410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN946_07420	COG1476	TRANSCRIPTIONal
AN946_07430	COG1131	(ABC) transporter
AN946_07435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN946_07440	COG0803	Belongs to the bacterial solute-binding protein 9 family
AN946_07445	COG1121	(ABC) transporter
AN946_07450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_07480	COG0647	UMP catabolic process
AN946_07490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN946_07495	COG0497	DNA recombination
AN946_07545	COG0396	ATPase activity
AN946_07560	COG2151	metal-sulfur cluster biosynthetic enzyme
AN946_07565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN946_07570	COG0488	(ABC) transporter
AN946_07580	COG3830	Belongs to the UPF0237 family
AN946_07580	COG0560	Phosphoserine phosphatase
AN946_07595	COG0297	glycogen (starch) synthase activity
AN946_07600	COG1119	ATPase activity
AN946_07630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN946_07635	COG1881	PFAM PEBP family protein
AN946_07650	COG0587	DNA-directed DNA polymerase activity
AN946_07675	COG0519	Catalyzes the synthesis of GMP from XMP
AN946_07675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN946_07685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN946_07700	COG1968	undecaprenyl-diphosphatase activity
AN946_07720	COG1222	aaa ATPase
AN946_07725	COG4122	O-methyltransferase activity
AN946_07735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AN946_07750	COG0107	imidazoleglycerol-phosphate synthase activity
AN946_07760	COG0134	indole-3-glycerol-phosphate synthase activity
AN946_07765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN946_07770	COG0469	pyruvate kinase activity
AN946_07795	COG0539	negative regulation of cytoplasmic translation
AN946_07820	COG1136	(ABC) transporter
AN946_07825	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AN946_07835	COG0556	nucleotide-excision repair
AN946_07840	COG0861	Integral membrane protein TerC family
AN946_07860	COG0322	excinuclease ABC activity
AN946_07865	COG1660	Displays ATPase and GTPase activities
AN946_07875	COG1481	regulation of sporulation
AN946_07880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN946_07885	COG0126	phosphoglycerate kinase activity
AN946_07890	COG0149	triose-phosphate isomerase activity
AN946_07895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN946_07910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN946_07935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AN946_07950	COG1160	GTP binding
AN946_07955	COG0205	6-phosphofructokinase activity
AN946_08000	COG1216	Glycosyl transferase, family 2
AN946_08010	COG4581	dead DEAH box helicase
AN946_08040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN946_08045	COG0140	phosphoribosyl-ATP diphosphatase activity
AN946_08050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN946_08055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN946_08060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN946_08070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN946_08075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN946_08080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN946_08090	COG1758	RNA polymerase activity
AN946_08095	COG0194	GDP metabolic process
AN946_08110	COG0505	Belongs to the CarA family
AN946_08120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN946_08130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN946_08140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN946_08160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN946_08165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN946_08175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN946_08185	COG2409	Drug exporters of the RND superfamily
AN946_08200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN946_08220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN946_08225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN946_08230	COG0124	histidyl-tRNA synthetase
AN946_08235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN946_08240	COG1196	nuclear chromosome segregation
AN946_08260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN946_08265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN946_08270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN946_08275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN946_08285	COG2255	four-way junction helicase activity
AN946_08290	COG0632	four-way junction helicase activity
AN946_08295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN946_08300	COG0217	transcriptional regulatory protein
AN946_08305	COG1051	belongs to the nudix hydrolase family
AN946_08315	COG0438	transferase activity, transferring glycosyl groups
AN946_08330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN946_08335	COG1760	l-serine dehydratase
AN946_08340	COG2197	response regulator
AN946_08365	COG4412	M6 family metalloprotease domain protein
AN946_08365	COG1404	Belongs to the peptidase S8 family
AN946_08415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN946_08425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AN946_08440	COG0569	domain protein
AN946_08485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN946_08500	COG0187	DNA topoisomerase II activity
AN946_08510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN946_08510	COG1199	ATP-dependent helicase activity
AN946_08545	COG2815	serine threonine protein kinase
AN946_08545	COG0515	serine threonine protein kinase
AN946_08550	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AN946_08555	COG0205	6-phosphofructokinase activity
AN946_08595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN946_08610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN946_08620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN946_08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN946_08645	COG0174	glutamine synthetase
AN946_08655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AN946_08660	COG0174	glutamine synthetase
AN946_08675	COG1940	carbohydrate kinase activity
AN946_08680	COG3022	response to hydroperoxide
AN946_08690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN946_08700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN946_08725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN946_08745	COG0009	L-threonylcarbamoyladenylate synthase
AN946_08765	COG1090	epimerase
AN946_08800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AN946_08805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_08845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN946_08850	COG0805	protein transport
AN946_08860	COG0358	DNA primase activity
AN946_08885	COG0423	glycine-tRNA ligase activity
AN946_08895	COG1121	(ABC) transporter
AN946_08900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_08905	COG0735	belongs to the Fur family
AN946_08920	COG0587	DNA-directed DNA polymerase activity
AN946_08935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN946_08950	COG1799	cell septum assembly
AN946_08960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN946_08970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN946_08975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN946_08980	COG0772	Belongs to the SEDS family
AN946_08985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN946_08990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN946_08995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN946_09000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN946_09005	COG0768	penicillin binding
AN946_09015	COG0275	rRNA processing
AN946_09020	COG2001	Belongs to the MraZ family
AN946_09050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN946_09060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN946_09070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN946_09090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AN946_09095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN946_09105	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN946_09115	COG1396	sequence-specific DNA binding
AN946_09135	COG1674	ftsk spoiiie
AN946_09140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AN946_09160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN946_09165	COG0612	Peptidase, M16
AN946_09175	COG1185	polyribonucleotide nucleotidyltransferase activity
AN946_09230	COG2271	Major facilitator Superfamily
AN946_09235	COG0745	RESPONSE REGULATOR receiver
AN946_09240	COG3852	Histidine kinase
AN946_09245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN946_09250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN946_09255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN946_09270	COG0779	Required for maturation of 30S ribosomal subunits
AN946_09280	COG0442	prolyl-tRNA aminoacylation
AN946_09290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AN946_09295	COG0750	zinc metalloprotease
AN946_09300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN946_09310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN946_09320	COG0233	cytoplasmic translational termination
AN946_09345	COG0644	oxidoreductase
AN946_09350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN946_09360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN946_09365	COG0052	Belongs to the universal ribosomal protein uS2 family
AN946_09370	COG2860	membrane
AN946_09375	COG4942	peptidase
AN946_09375	COG1388	LysM domain
AN946_09380	COG4974	Belongs to the 'phage' integrase family
AN946_09390	COG0606	chelatase, subunit chli
AN946_09405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN946_09410	COG0681	Belongs to the peptidase S26 family
AN946_09415	COG0335	large ribosomal subunit rRNA binding
AN946_09425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN946_09430	COG1837	Belongs to the UPF0109 family
AN946_09435	COG0228	four-way junction DNA binding
AN946_09440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AN946_09480	COG0105	UTP biosynthetic process
AN946_09485	COG0285	dihydrofolate synthase activity
AN946_09490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN946_09505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN946_09525	COG1605	Chorismate mutase
AN946_09525	COG0287	Prephenate dehydrogenase
AN946_09530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN946_09535	COG0740	serine-type endopeptidase activity
AN946_09540	COG0740	serine-type endopeptidase activity
AN946_09545	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN946_09550	COG0667	Aldo Keto reductase
AN946_09570	COG3250	beta-galactosidase activity
AN946_09575	COG1609	Transcriptional regulator
AN946_09610	COG4824	toxin secretion phage lysis holin
AN946_09690	COG4695	Portal protein
AN946_09700	COG1802	Transcriptional regulator
AN946_09700	COG4626	Terminase
AN946_09730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN946_09775	COG3617	BRO family, N-terminal domain
AN946_09785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN946_09785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN946_09845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN946_09875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN946_09890	COG1739	Uncharacterized protein family UPF0029
AN946_09900	COG1045	serine acetyltransferase
AN946_09915	COG3590	peptidase
AN946_09920	COG2354	Protein conserved in bacteria
AN946_09930	COG0519	Catalyzes the synthesis of GMP from XMP
AN946_09945	COG1946	Acyl-CoA thioesterase
AN946_09975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN946_10095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN946_10110	COG0463	Glycosyl transferase, family 2
AN946_10115	COG2244	polysaccharide biosynthetic process
AN946_10140	COG1442	glycosyl transferase family 8
AN946_10140	COG1216	Glycosyl transferase, family 2
AN946_10145	COG3475	LICD family
AN946_10150	COG4750	Nucleotidyl transferase
AN946_10155	COG0438	transferase activity, transferring glycosyl groups
AN946_10185	COG1882	Formate acetyltransferase
AN946_10190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN946_10205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN946_10210	COG0440	acetolactate synthase activity
AN946_10220	COG0569	domain protein
AN946_10220	COG2985	domain, Protein
AN946_10225	COG0129	dihydroxy-acid dehydratase activity