locus-tag	class	description
K5713_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5713_00010	COG0592	DNA-directed DNA polymerase activity
K5713_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5713_00025	COG0187	DNA topoisomerase II activity
K5713_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5713_00075	COG0457	Tetratricopeptide repeat
K5713_00075	COG0705	Rhomboid family
K5713_00085	COG3764	Sortase (surface protein transpeptidase)
K5713_00115	COG1716	ATPase activity
K5713_00120	COG1716	ATPase activity
K5713_00120	COG1131	(ABC) transporter
K5713_00120	COG0842	Transport permease protein
K5713_00150	COG0582	viral genome integration into host DNA
K5713_00175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5713_00180	COG1854	S-ribosylhomocysteine lyase activity
K5713_00195	COG1780	Probably involved in ribonucleotide reductase function
K5713_00200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5713_00205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5713_00215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5713_00220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5713_00235	COG0395	ABC-type sugar transport system, permease component
K5713_00240	COG1175	transmembrane transport
K5713_00260	COG2072	flavoprotein involved in K transport
K5713_00270	COG1643	Atp-dependent helicase
K5713_00275	COG2197	response regulator
K5713_00280	COG4585	Histidine kinase
K5713_00290	COG1131	(ABC) transporter
K5713_00300	COG1136	(ABC) transporter
K5713_00310	COG2197	response regulator
K5713_00320	COG1328	CTP reductase activity
K5713_00345	COG1136	(ABC) transporter
K5713_00350	COG1414	Transcriptional regulator
K5713_00355	COG0246	Mannitol dehydrogenase
K5713_00360	COG1312	Catalyzes the dehydration of D-mannonate
K5713_00365	COG0800	Aldolase
K5713_00370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5713_00375	COG1120	ATPase activity
K5713_00385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_00400	COG1132	(ABC) transporter
K5713_00405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5713_00410	COG1609	Transcriptional regulator
K5713_00425	COG1175	transmembrane transport
K5713_00430	COG0395	ABC-type sugar transport system, permease component
K5713_00465	COG1487	ribonuclease activity
K5713_00480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5713_00510	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5713_00515	COG1879	ABC-type sugar transport system periplasmic component
K5713_00550	COG0561	phosphatase activity
K5713_00555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5713_00570	COG0077	Prephenate dehydratase
K5713_00595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5713_00615	COG4868	Belongs to the UPF0371 family
K5713_00620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5713_00675	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5713_00685	COG0315	cyclic pyranopterin monophosphate synthase activity
K5713_00695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5713_00720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5713_00755	COG0596	Alpha beta hydrolase
K5713_00800	COG1111	helicase
K5713_00800	COG1205	dead DEAH box helicase
K5713_00805	COG3655	Transcriptional regulator
K5713_00815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5713_00815	COG2890	protein-(glutamine-N5) methyltransferase activity
K5713_00820	COG1754	DNA topoisomerase type I activity
K5713_00820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5713_00825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5713_00830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5713_00930	COG2184	nucleotidyltransferase activity
K5713_00955	COG1192	Involved in chromosome partitioning
K5713_00965	COG4974	Belongs to the 'phage' integrase family
K5713_00985	COG2801	Transposase and inactivated derivatives
K5713_01020	COG0717	Belongs to the dCTP deaminase family
K5713_01025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5713_01025	COG2111	Na H antiporter
K5713_01030	COG1006	Multisubunit Na H antiporter MnhC subunit
K5713_01035	COG0651	ATP synthesis coupled electron transport
K5713_01065	COG4149	molybdate abc transporter
K5713_01070	COG3842	ATPase activity
K5713_01085	COG0662	Cupin 2, conserved barrel domain protein
K5713_01125	COG1940	carbohydrate kinase activity
K5713_01130	COG0390	transport system, permease component
K5713_01140	COG1505	serine-type exopeptidase activity
K5713_01150	COG0437	4 iron, 4 sulfur cluster binding
K5713_01155	COG0243	molybdopterin cofactor binding
K5713_01160	COG1937	Protein conserved in bacteria
K5713_01165	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5713_01175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K5713_01180	COG0540	Belongs to the ATCase OTCase family
K5713_01185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5713_01190	COG0284	orotidine-5'-phosphate decarboxylase activity
K5713_01195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5713_01200	COG0167	dihydroorotate dehydrogenase activity
K5713_01205	COG0443	Heat shock 70 kDa protein
K5713_01210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5713_01215	COG0484	heat shock protein binding
K5713_01220	COG0789	Transcriptional regulator
K5713_01240	COG0584	glycerophosphoryl diester phosphodiesterase
K5713_01250	COG1506	peptidase
K5713_01250	COG0823	Involved in the tonB-independent uptake of proteins
K5713_01260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5713_01290	COG1028	Short-chain dehydrogenase reductase Sdr
K5713_01305	COG0494	nUDIX hydrolase
K5713_01320	COG0191	fructose-bisphosphate aldolase activity
K5713_01330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5713_01335	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
K5713_01340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5713_01345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5713_01375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5713_01405	COG0039	L-malate dehydrogenase activity
K5713_01410	COG0728	peptidoglycan biosynthetic process
K5713_01435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5713_01460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5713_01465	COG0494	nUDIX hydrolase
K5713_01465	COG0406	alpha-ribazole phosphatase activity
K5713_01470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5713_01485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5713_01490	COG0306	phosphate transporter
K5713_01500	COG1115	amino acid carrier protein
K5713_01510	COG0737	Belongs to the 5'-nucleotidase family
K5713_01525	COG3485	protocatechuate 3,4-dioxygenase
K5713_01530	COG0354	folic acid binding
K5713_01540	COG1490	D-aminoacyl-tRNA deacylase activity
K5713_01560	COG0738	Major facilitator superfamily
K5713_01565	COG2390	Transcriptional regulator
K5713_01585	COG1349	DNA-binding transcription factor activity
K5713_01605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5713_01610	COG2376	Dihydroxyacetone kinase
K5713_01620	COG0698	ribose 5-phosphate isomerase
K5713_01625	COG0730	response to heat
K5713_01630	COG0641	radical SAM
K5713_01635	COG2814	Major facilitator Superfamily
K5713_01640	COG1609	Transcriptional regulator
K5713_01645	COG3119	arylsulfatase activity
K5713_01655	COG0395	ABC-type sugar transport system, permease component
K5713_01670	COG1501	Belongs to the glycosyl hydrolase 31 family
K5713_01680	COG1349	DNA-binding transcription factor activity
K5713_01690	COG1175	transmembrane transport
K5713_01695	COG0395	ABC-type sugar transport system, permease component
K5713_01720	COG2115	Belongs to the xylose isomerase family
K5713_01725	COG1070	Carbohydrate kinase
K5713_01730	COG4213	ABC transporter substrate-binding protein
K5713_01740	COG4214	carbohydrate transport
K5713_01745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5713_01750	COG1757	Na H antiporter
K5713_01760	COG3250	beta-galactosidase activity
K5713_01770	COG0395	ABC-type sugar transport system, permease component
K5713_01780	COG1609	Transcriptional regulator
K5713_01790	COG0395	ABC-type sugar transport system, permease component
K5713_01795	COG1175	transmembrane transport
K5713_01810	COG3250	beta-galactosidase activity
K5713_01820	COG1609	Transcriptional regulator
K5713_01830	COG2610	gluconate transmembrane transporter activity
K5713_01845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5713_01855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
K5713_01860	COG3250	beta-galactosidase activity
K5713_01865	COG1869	D-ribose catabolic process
K5713_01875	COG1879	ABC-type sugar transport system periplasmic component
K5713_01880	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5713_01885	COG1129	ABC transporter
K5713_01890	COG1609	Transcriptional regulator
K5713_01895	COG2226	methyltransferase
K5713_01900	COG1116	anion transmembrane transporter activity
K5713_01900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5713_01920	COG0737	Belongs to the 5'-nucleotidase family
K5713_01930	COG1609	Transcriptional regulator
K5713_01935	COG2271	Major facilitator Superfamily
K5713_01940	COG1285	pathogenesis
K5713_01960	COG3177	Filamentation induced by cAMP protein fic
K5713_01965	COG1715	Restriction endonuclease
K5713_01970	COG5290	Psort location Cytoplasmic, score
K5713_01990	COG0366	Alpha amylase catalytic
K5713_01995	COG0395	ABC-type sugar transport system, permease component
K5713_02000	COG1175	transmembrane transport
K5713_02015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5713_02015	COG0574	Belongs to the PEP-utilizing enzyme family
K5713_02020	COG0277	FAD linked oxidase domain protein
K5713_02020	COG0247	lactate metabolic process
K5713_02030	COG2267	carboxylic ester hydrolase activity
K5713_02035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5713_02040	COG0791	NLP P60 protein
K5713_02045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K5713_02060	COG0037	tRNA processing
K5713_02070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5713_02075	COG0302	gtp cyclohydrolase
K5713_02085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5713_02105	COG1609	Transcriptional regulator
K5713_02125	COG3250	beta-galactosidase activity
K5713_02135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5713_02135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5713_02140	COG1461	Dihydroxyacetone kinase
K5713_02145	COG2376	Dihydroxyacetone kinase
K5713_02155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5713_02160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K5713_02170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5713_02175	COG2409	Drug exporters of the RND superfamily
K5713_02180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5713_02185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5713_02195	COG3386	PFAM SMP-30 Gluconolaconase
K5713_02200	COG0247	lactate metabolic process
K5713_02205	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K5713_02210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5713_02225	COG1194	a g-specific adenine glycosylase
K5713_02235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5713_02240	COG0569	domain protein
K5713_02245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5713_02260	COG1846	Transcriptional regulator
K5713_02265	COG0406	alpha-ribazole phosphatase activity
K5713_02290	COG0395	ABC-type sugar transport system, permease component
K5713_02295	COG1175	transmembrane transport
K5713_02305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K5713_02310	COG4948	Mandelate Racemase Muconate Lactonizing
K5713_02315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K5713_02320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5713_02325	COG1169	isochorismate synthase
K5713_02330	COG2226	methyltransferase
K5713_02335	COG0644	oxidoreductase
K5713_02345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5713_02350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5713_02355	COG0649	NAD binding
K5713_02365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K5713_02370	COG1034	ATP synthesis coupled electron transport
K5713_02375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K5713_02380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K5713_02385	COG0839	Belongs to the complex I subunit 6 family
K5713_02390	COG0713	ATP synthesis coupled electron transport
K5713_02405	COG1007	ATP synthesis coupled electron transport
K5713_02410	COG0142	geranyltranstransferase activity
K5713_02415	COG0653	protein targeting
K5713_02455	COG0419	ATPase involved in DNA repair
K5713_02460	COG0420	3'-5' exonuclease activity
K5713_02465	COG0483	inositol monophosphate 1-phosphatase activity
K5713_02470	COG1162	GTPase activity
K5713_02475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K5713_02500	COG0657	acetylesterase activity
K5713_02515	COG0601	transmembrane transport
K5713_02520	COG0444	Belongs to the ABC transporter superfamily
K5713_02525	COG4608	Belongs to the ABC transporter superfamily
K5713_02530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5713_02540	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5713_02545	COG0363	glucosamine-6-phosphate deaminase activity
K5713_02555	COG1595	DNA-templated transcription, initiation
K5713_02570	COG0791	NLP P60 protein
K5713_02570	COG1388	LysM domain
K5713_02570	COG3103	Sh3 type 3 domain protein
K5713_02580	COG0567	Dehydrogenase, E1 component
K5713_02580	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5713_02585	COG1253	flavin adenine dinucleotide binding
K5713_02595	COG0739	heme binding
K5713_02640	COG0018	arginyl-trna synthetase
K5713_02650	COG0460	homoserine dehydrogenase
K5713_02655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5713_02660	COG0083	homoserine kinase activity
K5713_02675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5713_02700	COG0356	it plays a direct role in the translocation of protons across the membrane
K5713_02705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5713_02710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5713_02715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5713_02720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5713_02725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5713_02730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5713_02735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5713_02745	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
K5713_02790	COG1609	Transcriptional regulator
K5713_02800	COG1175	transmembrane transport
K5713_02805	COG3833	ABC-type maltose transport systems, permease component
K5713_02815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5713_02820	COG3281	Trehalose synthase
K5713_02825	COG0366	Alpha amylase catalytic
K5713_02830	COG0366	Alpha amylase catalytic
K5713_02855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5713_02860	COG0058	SHG alpha-glucan phosphorylase activity
K5713_02865	COG0180	Tryptophanyl-tRNA synthetase
K5713_02895	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5713_02905	COG1615	UPF0182 protein
K5713_02910	COG0366	Alpha amylase catalytic
K5713_02910	COG1470	cell adhesion involved in biofilm formation
K5713_02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5713_02945	COG1131	(ABC) transporter
K5713_02955	COG0387	Pfam Sodium calcium exchanger
K5713_02965	COG1053	succinate dehydrogenase
K5713_02990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5713_03025	COG4585	Histidine kinase
K5713_03040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5713_03050	COG1397	ADP-ribosylglycohydrolase
K5713_03060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5713_03075	COG1404	Belongs to the peptidase S8 family
K5713_03080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5713_03085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5713_03090	COG0154	amidase activity
K5713_03095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5713_03145	COG0129	dihydroxy-acid dehydratase activity
K5713_03150	COG2985	domain, Protein
K5713_03150	COG0569	domain protein
K5713_03160	COG0440	acetolactate synthase activity
K5713_03165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5713_03185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5713_03190	COG1882	Formate acetyltransferase
K5713_03220	COG0438	transferase activity, transferring glycosyl groups
K5713_03225	COG4750	Nucleotidyl transferase
K5713_03230	COG3475	LICD family
K5713_03235	COG1442	glycosyl transferase family 8
K5713_03235	COG1216	Glycosyl transferase, family 2
K5713_03260	COG2244	polysaccharide biosynthetic process
K5713_03265	COG0463	Glycosyl transferase, family 2
K5713_03295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5713_03325	COG1946	Acyl-CoA thioesterase
K5713_03340	COG0519	Catalyzes the synthesis of GMP from XMP
K5713_03350	COG2354	Protein conserved in bacteria
K5713_03355	COG3590	peptidase
K5713_03365	COG1045	serine acetyltransferase
K5713_03375	COG1739	Uncharacterized protein family UPF0029
K5713_03390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5713_03405	COG0488	(ABC) transporter
K5713_03420	COG1609	Transcriptional regulator
K5713_03425	COG3250	beta-galactosidase activity
K5713_03445	COG0667	Aldo Keto reductase
K5713_03450	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5713_03455	COG0740	serine-type endopeptidase activity
K5713_03460	COG0740	serine-type endopeptidase activity
K5713_03465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5713_03470	COG1605	Chorismate mutase
K5713_03470	COG0287	Prephenate dehydrogenase
K5713_03490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5713_03505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5713_03510	COG0285	dihydrofolate synthase activity
K5713_03515	COG0105	UTP biosynthetic process
K5713_03555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5713_03560	COG0228	four-way junction DNA binding
K5713_03565	COG1837	Belongs to the UPF0109 family
K5713_03570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5713_03580	COG0335	large ribosomal subunit rRNA binding
K5713_03585	COG0681	Belongs to the peptidase S26 family
K5713_03590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5713_03615	COG4974	Belongs to the 'phage' integrase family
K5713_03620	COG1388	LysM domain
K5713_03620	COG4942	peptidase
K5713_03625	COG2860	membrane
K5713_03630	COG0052	Belongs to the universal ribosomal protein uS2 family
K5713_03635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5713_03645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K5713_03650	COG0644	oxidoreductase
K5713_03675	COG0233	cytoplasmic translational termination
K5713_03685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5713_03695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5713_03700	COG0750	zinc metalloprotease
K5713_03705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5713_03715	COG0442	prolyl-tRNA aminoacylation
K5713_03725	COG0779	Required for maturation of 30S ribosomal subunits
K5713_03740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5713_03745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5713_03750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5713_03755	COG3852	Histidine kinase
K5713_03760	COG0745	RESPONSE REGULATOR receiver
K5713_03765	COG2271	Major facilitator Superfamily
K5713_03775	COG3842	ATPase activity
K5713_03820	COG1185	polyribonucleotide nucleotidyltransferase activity
K5713_03830	COG0612	Peptidase, M16
K5713_03835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5713_03840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5713_03855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K5713_03860	COG1674	ftsk spoiiie
K5713_03875	COG1058	Belongs to the CinA family
K5713_03875	COG1546	Belongs to the CinA family
K5713_03880	COG1396	sequence-specific DNA binding
K5713_03890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5713_03895	COG2137	regulation of response to DNA damage stimulus
K5713_03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5713_03905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5713_03915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5713_03925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5713_03935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5713_03940	COG0318	PFAM AMP-dependent synthetase and ligase
K5713_03945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5713_03965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5713_03975	COG2001	Belongs to the MraZ family
K5713_03980	COG0275	rRNA processing
K5713_03990	COG0768	penicillin binding
K5713_03995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5713_04000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5713_04005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5713_04010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5713_04015	COG0772	Belongs to the SEDS family
K5713_04020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5713_04025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5713_04035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5713_04045	COG1799	cell septum assembly
K5713_04060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5713_04075	COG0587	DNA-directed DNA polymerase activity
K5713_04090	COG0735	belongs to the Fur family
K5713_04095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5713_04100	COG1121	(ABC) transporter
K5713_04110	COG0423	glycine-tRNA ligase activity
K5713_04135	COG0358	DNA primase activity
K5713_04145	COG0805	protein transport
K5713_04150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5713_04185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_04190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K5713_04340	COG1090	epimerase
K5713_04360	COG0009	L-threonylcarbamoyladenylate synthase
K5713_04380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5713_04405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5713_04410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5713_04415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5713_04435	COG1940	carbohydrate kinase activity
K5713_04450	COG0174	glutamine synthetase
K5713_04455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5713_04465	COG0174	glutamine synthetase
K5713_04485	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5713_04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5713_04500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5713_04515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5713_04555	COG0205	6-phosphofructokinase activity
K5713_04560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5713_04565	COG0515	serine threonine protein kinase
K5713_04565	COG2815	serine threonine protein kinase
K5713_04580	COG0142	geranyltranstransferase activity
K5713_04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5713_04600	COG1199	ATP-dependent helicase activity
K5713_04600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5713_04610	COG0187	DNA topoisomerase II activity
K5713_04625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5713_04665	COG0569	domain protein
K5713_04680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K5713_04690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5713_04755	COG2197	response regulator
K5713_04760	COG1760	l-serine dehydratase
K5713_04765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5713_04770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5713_04780	COG0438	transferase activity, transferring glycosyl groups
K5713_04790	COG1051	belongs to the nudix hydrolase family
K5713_04795	COG0217	transcriptional regulatory protein
K5713_04800	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5713_04805	COG0632	four-way junction helicase activity
K5713_04810	COG2255	four-way junction helicase activity
K5713_04820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5713_04825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5713_04830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5713_04835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5713_04845	COG1196	nuclear chromosome segregation
K5713_04850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5713_04855	COG0124	histidyl-tRNA synthetase
K5713_04860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5713_04865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5713_04885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5713_04900	COG2409	Drug exporters of the RND superfamily
K5713_04910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5713_04920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5713_04925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5713_04945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5713_04955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5713_04960	COG2217	Heavy metal translocating P-type atpase
K5713_04965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5713_04970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5713_04975	COG0505	Belongs to the CarA family
K5713_04980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5713_04990	COG0194	GDP metabolic process
K5713_04995	COG1758	RNA polymerase activity
K5713_05005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5713_05010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5713_05015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5713_05025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5713_05030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5713_05035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5713_05040	COG0140	phosphoribosyl-ATP diphosphatase activity
K5713_05045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5713_05075	COG4581	dead DEAH box helicase
K5713_05085	COG1216	Glycosyl transferase, family 2
K5713_05125	COG0205	6-phosphofructokinase activity
K5713_05130	COG1160	GTP binding
K5713_05145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5713_05170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K5713_05185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5713_05190	COG0149	triose-phosphate isomerase activity
K5713_05195	COG0126	phosphoglycerate kinase activity
K5713_05200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5713_05205	COG1481	regulation of sporulation
K5713_05220	COG0322	excinuclease ABC activity
K5713_05225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5713_05245	COG0556	nucleotide-excision repair
K5713_05250	COG0237	dephospho-CoA kinase activity
K5713_05255	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K5713_05260	COG1136	(ABC) transporter
K5713_05270	COG0539	negative regulation of cytoplasmic translation
K5713_05295	COG0469	pyruvate kinase activity
K5713_05300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5713_05305	COG0134	indole-3-glycerol-phosphate synthase activity
K5713_05315	COG0107	imidazoleglycerol-phosphate synthase activity
K5713_05330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
K5713_05340	COG4122	O-methyltransferase activity
K5713_05345	COG1222	aaa ATPase
K5713_05365	COG1968	undecaprenyl-diphosphatase activity
K5713_05380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5713_05390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5713_05390	COG0519	Catalyzes the synthesis of GMP from XMP
K5713_05415	COG0587	DNA-directed DNA polymerase activity
K5713_05430	COG1881	PFAM PEBP family protein
K5713_05465	COG1119	ATPase activity
K5713_05470	COG0297	glycogen (starch) synthase activity
K5713_05480	COG1136	(ABC) transporter
K5713_05490	COG0560	Phosphoserine phosphatase
K5713_05490	COG3830	Belongs to the UPF0237 family
K5713_05500	COG0488	(ABC) transporter
K5713_05505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5713_05510	COG2151	metal-sulfur cluster biosynthetic enzyme
K5713_05525	COG0396	ATPase activity
K5713_05555	COG0728	peptidoglycan biosynthetic process
K5713_05575	COG0497	DNA recombination
K5713_05580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5713_05595	COG0647	UMP catabolic process
K5713_05625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5713_05630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5713_05635	COG1121	(ABC) transporter
K5713_05640	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5713_05645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5713_05660	COG1476	TRANSCRIPTIONal
K5713_05670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5713_05675	COG1438	arginine binding
K5713_05690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5713_05695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5713_05705	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5713_05710	COG1902	pentaerythritol trinitrate reductase activity
K5713_05715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5713_05730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5713_05735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5713_05745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5713_05750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5713_05760	COG0131	Imidazoleglycerol-phosphate dehydratase
K5713_05770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5713_05775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5713_05780	COG1381	Involved in DNA repair and RecF pathway recombination
K5713_05785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5713_05820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5713_05830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5713_05835	COG0484	heat shock protein binding
K5713_05840	COG1420	regulation of RNA biosynthetic process
K5713_05860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5713_05865	COG0481	GTPase activity
K5713_05890	COG0268	Binds directly to 16S ribosomal RNA
K5713_05895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K5713_05900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5713_05920	COG0433	COG0433 Predicted ATPase
K5713_05935	COG0495	leucyl-tRNA aminoacylation
K5713_05960	COG0813	purine-nucleoside phosphorylase activity
K5713_05970	COG1435	thymidine kinase activity
K5713_05990	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5713_06000	COG1121	(ABC) transporter
K5713_06005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5713_06025	COG0671	phosphoesterase, PA-phosphatase related
K5713_06045	COG1113	amino acid transport
K5713_06050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K5713_06050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K5713_06060	COG2011	ABC-type metal ion transport system permease component
K5713_06065	COG1464	Belongs to the NlpA lipoprotein family
K5713_06070	COG1113	amino acid transport
K5713_06080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K5713_06085	COG2186	Transcriptional regulator
K5713_06090	COG0477	Major facilitator Superfamily
K5713_06100	COG0826	peptidase U32
K5713_06105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K5713_06110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K5713_06115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5713_06160	COG0726	polysaccharide deacetylase
K5713_06165	COG0133	tryptophan synthase activity
K5713_06170	COG1609	Transcriptional regulator
K5713_06180	COG0738	Major facilitator superfamily
K5713_06185	COG0235	Class ii aldolase
K5713_06220	COG0406	alpha-ribazole phosphatase activity
K5713_06225	COG0799	negative regulation of ribosome biogenesis
K5713_06235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5713_06240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5713_06250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5713_06260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5713_06265	COG1530	ribonuclease E activity
K5713_06270	COG1271	oxidase subunit
K5713_06275	COG1294	oxidase, subunit
K5713_06280	COG4988	ABC transporter
K5713_06285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5713_06295	COG1132	(ABC) transporter
K5713_06300	COG1132	(ABC) transporter
K5713_06320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5713_06325	COG0571	ribonuclease III activity
K5713_06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5713_06355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5713_06365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K5713_06375	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5713_06380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5713_06400	COG0438	transferase activity, transferring glycosyl groups
K5713_06415	COG4975	Glucose uptake
K5713_06420	COG0339	signal peptide processing
K5713_06475	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5713_06510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5713_06515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5713_06525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K5713_06535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K5713_06560	COG2985	domain, Protein
K5713_06560	COG0569	domain protein
K5713_06575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5713_06620	COG1136	(ABC) transporter
K5713_06620	COG0577	efflux transmembrane transporter activity
K5713_06660	COG1619	proteins homologs of microcin C7 resistance protein MccF
K5713_06675	COG0739	heme binding
K5713_06680	COG2177	Part of the ABC transporter FtsEX involved in
K5713_06685	COG2884	Cell division ATP-binding protein ftsE
K5713_06690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K5713_06750	COG0513	Belongs to the DEAD box helicase family
K5713_06755	COG2095	MarC family integral membrane protein
K5713_06765	COG0006	proline dipeptidase activity
K5713_06770	COG2239	Acts as a magnesium transporter
K5713_06795	COG1611	Belongs to the LOG family
K5713_06805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5713_06810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K5713_06830	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5713_06835	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5713_06840	COG3845	ABC transporter
K5713_06845	COG1744	ABC transporter substrate-binding protein PnrA-like
K5713_06850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K5713_06850	COG0662	Cupin 2, conserved barrel domain protein
K5713_06865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5713_06870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5713_06880	COG1268	BioY protein
K5713_06885	COG0736	holo-[acyl-carrier-protein] synthase activity
K5713_06890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5713_06895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5713_06900	COG4770	biotin carboxylase activity
K5713_06920	COG0644	oxidoreductase
K5713_06925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K5713_06940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5713_06945	COG2271	Major facilitator Superfamily
K5713_06950	COG2030	dehydratase
K5713_06980	COG0110	maltose O-acetyltransferase activity
K5713_06990	COG0039	L-malate dehydrogenase activity
K5713_07000	COG0166	Belongs to the GPI family
K5713_07005	COG0205	6-phosphofructokinase activity
K5713_07035	COG0045	succinate-CoA ligase (ADP-forming) activity
K5713_07040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5713_07040	COG2755	lipolytic protein G-D-S-L family
K5713_07095	COG4974	Belongs to the 'phage' integrase family
K5713_07120	COG0280	phosphate acetyltransferase
K5713_07120	COG0857	belongs to the CobB CobQ family
K5713_07125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5713_07140	COG1136	(ABC) transporter
K5713_07150	COG0114	fumarate hydratase activity
K5713_07155	COG0516	GMP reductase activity
K5713_07180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5713_07185	COG0151	Belongs to the GarS family
K5713_07190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5713_07195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5713_07200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K5713_07205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5713_07210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5713_07220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K5713_07230	COG0428	transporter
K5713_07235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5713_07240	COG0733	neurotransmitter:sodium symporter activity
K5713_07250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5713_07255	COG1053	succinate dehydrogenase
K5713_07280	COG0802	atpase or kinase
K5713_07285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5713_07295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5713_07300	COG1072	(Pantothenic acid kinase))
K5713_07310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5713_07315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5713_07325	COG4720	Psort location CytoplasmicMembrane, score
K5713_07330	COG1122	ATPase activity
K5713_07350	COG0101	tRNA pseudouridine synthase activity
K5713_07355	COG1940	carbohydrate kinase activity
K5713_07365	COG0765	amino acid transport
K5713_07370	COG4598	ABC transporter
K5713_07375	COG0789	Transcriptional regulator
K5713_07390	COG0203	ribosomal protein L17
K5713_07395	COG0202	RNA polymerase activity
K5713_07405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5713_07410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5713_07415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5713_07425	COG0563	adenylate kinase activity
K5713_07435	COG0200	Binds to the 23S rRNA
K5713_07440	COG1841	ribosomal large subunit assembly
K5713_07445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5713_07455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5713_07460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5713_07465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5713_07470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5713_07475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5713_07480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5713_07495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5713_07500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5713_07505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5713_07510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5713_07515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5713_07520	COG0089	rRNA binding
K5713_07525	COG0088	Forms part of the polypeptide exit tunnel
K5713_07530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5713_07535	COG0051	transcription antitermination factor activity, RNA binding
K5713_07540	COG0546	phosphoglycolate phosphatase activity
K5713_07550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5713_07555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5713_07560	COG0049	tRNA binding
K5713_07565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5713_07570	COG0833	amino acid
K5713_07575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5713_07580	COG0085	RNA polymerase activity
K5713_07585	COG0222	ribosome binding
K5713_07590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5713_07600	COG0081	regulation of translation
K5713_07605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5713_07610	COG0250	Participates in transcription elongation, termination and antitermination
K5713_07625	COG0436	Aminotransferase
K5713_07635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5713_07650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5713_07660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5713_07680	COG1666	GTP binding
K5713_07690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5713_07695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5713_07700	COG5401	PFAM Sporulation and spore germination
K5713_07705	COG5002	protein histidine kinase activity
K5713_07705	COG5000	phosphorelay sensor kinase activity
K5713_07710	COG0745	RESPONSE REGULATOR receiver
K5713_07730	COG0714	Associated with various cellular activities
K5713_07775	COG0483	inositol monophosphate 1-phosphatase activity
K5713_07790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K5713_07885	COG0673	inositol 2-dehydrogenase activity
K5713_07910	COG1088	dTDP-glucose 4,6-dehydratase activity
K5713_07925	COG1316	TRANSCRIPTIONal
K5713_07930	COG1316	TRANSCRIPTIONal
K5713_07940	COG0642	Histidine kinase
K5713_07945	COG0745	RESPONSE REGULATOR receiver
K5713_07960	COG0424	maF-like protein
K5713_07995	COG1217	gtp-binding protein TYPA
K5713_08005	COG1132	(ABC) transporter
K5713_08035	COG0321	lipoyl(octanoyl) transferase activity
K5713_08040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K5713_08050	COG1362	aminopeptidase activity
K5713_08065	COG2838	Isocitrate dehydrogenase
K5713_08070	COG2391	methyltransferase activity
K5713_08075	COG0425	Belongs to the sulfur carrier protein TusA family
K5713_08080	COG0366	Alpha amylase catalytic
K5713_08085	COG1501	Belongs to the glycosyl hydrolase 31 family
K5713_08095	COG0395	ABC-type sugar transport system, permease component
K5713_08100	COG1175	transmembrane transport
K5713_08105	COG1846	Transcriptional regulator
K5713_08105	COG1940	carbohydrate kinase activity
K5713_08130	COG4608	Belongs to the ABC transporter superfamily
K5713_08135	COG0444	Belongs to the ABC transporter superfamily
K5713_08140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5713_08155	COG2116	formate transmembrane transporter activity
K5713_08165	COG0242	peptide deformylase activity
K5713_08170	COG1970	mechanosensitive ion channel activity
K5713_08195	COG1780	Probably involved in ribonucleotide reductase function
K5713_08205	COG0431	NADPH-dependent FMN reductase
K5713_08210	COG3226	Transcriptional regulator
K5713_08215	COG0477	Major facilitator Superfamily
K5713_08225	COG1834	amidinotransferase
K5713_08230	COG0549	Belongs to the carbamate kinase family
K5713_08235	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5713_08255	COG0395	ABC-type sugar transport system, permease component
K5713_08270	COG0366	Alpha amylase catalytic
K5713_08285	COG0477	Major facilitator Superfamily
K5713_08310	COG0012	GTP binding
K5713_08315	COG1322	Protein conserved in bacteria
K5713_08320	COG1162	GTPase activity
K5713_08335	COG4555	ABC transporter
K5713_08350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5713_08360	COG1722	exodeoxyribonuclease VII activity
K5713_08365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5713_08370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5713_08380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K5713_08385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5713_08390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5713_08405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5713_08410	COG1012	belongs to the aldehyde dehydrogenase family
K5713_08425	COG1131	(ABC) transporter
K5713_08430	COG1725	Transcriptional regulator
K5713_08455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5713_08475	COG0148	phosphopyruvate hydratase activity
K5713_08490	COG0193	aminoacyl-tRNA hydrolase activity
K5713_08495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5713_08505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5713_08515	COG1309	transcriptional regulator
K5713_08530	COG4152	abc transporter atp-binding protein
K5713_08535	COG1668	transmembrane transport
K5713_08545	COG0488	(ABC) transporter
K5713_08550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5713_08555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5713_08565	COG0084	hydrolase, TatD family'
K5713_08570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5713_08575	COG1335	isochorismatase
K5713_08595	COG2873	o-acetylhomoserine
K5713_08620	COG1131	(ABC) transporter
K5713_08635	COG2813	Specifically methylates the guanine in position
K5713_08640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5713_08665	COG1620	l-lactate permease
K5713_08670	COG0247	lactate metabolic process
K5713_08680	COG1556	Lactate utilization protein
K5713_08700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5713_08705	COG2190	(PTS) system
K5713_08710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5713_08710	COG1263	PTS System
K5713_08730	COG1051	belongs to the nudix hydrolase family
K5713_08740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5713_08750	COG3711	transcriptional antiterminator
K5713_08765	COG1511	domain protein
K5713_08775	COG2848	UPF0210 protein
K5713_08780	COG3830	Belongs to the UPF0237 family
K5713_08795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5713_08800	COG0254	rRNA binding
K5713_08805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5713_08810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5713_08815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5713_08830	COG0477	Major facilitator Superfamily
K5713_08835	COG0657	acetylesterase activity
K5713_08840	COG2188	Transcriptional regulator
K5713_08845	COG1120	ATPase activity
K5713_08850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_08855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_08860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K5713_08880	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5713_08945	COG1388	LysM domain
K5713_08945	COG0791	NLP P60 protein
K5713_08955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5713_08960	COG2252	PERMEase
K5713_08975	COG1278	Cold shock
K5713_08985	COG1842	Phage shock protein A
K5713_08995	COG0745	RESPONSE REGULATOR receiver
K5713_09000	COG2205	protein histidine kinase activity
K5713_09010	COG1028	Short-chain dehydrogenase reductase Sdr
K5713_09025	COG0459	protein refolding
K5713_09040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5713_09065	COG1131	(ABC) transporter
K5713_09085	COG3842	ATPase activity
K5713_09095	COG0673	inositol 2-dehydrogenase activity
K5713_09105	COG1653	transport
K5713_09110	COG1175	transmembrane transport
K5713_09140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5713_09155	COG1966	Carbon starvation protein
K5713_09180	COG2233	PERMEase
K5713_09195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5713_09200	COG0215	cysteine-tRNA ligase activity
K5713_09210	COG1136	(ABC) transporter
K5713_09230	COG2376	Dihydroxyacetone kinase
K5713_09245	COG3775	system Galactitol-specific IIC component
K5713_09275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5713_09280	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K5713_09295	COG5002	protein histidine kinase activity
K5713_09310	COG0588	phosphoglycerate mutase activity
K5713_09355	COG1120	ATPase activity
K5713_09360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_09390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5713_09395	COG0667	Aldo Keto reductase
K5713_09405	COG0710	3-dehydroquinate dehydratase activity
K5713_09420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5713_09425	COG1950	PFAM Membrane protein of
K5713_09430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5713_09435	COG0586	Pfam SNARE associated Golgi protein
K5713_09465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5713_09470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_09475	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_09480	COG1120	ATPase activity
K5713_09495	COG1063	alcohol dehydrogenase
K5713_09500	COG1609	Transcriptional regulator
K5713_09505	COG2271	Major facilitator Superfamily
K5713_09510	COG0483	inositol monophosphate 1-phosphatase activity
K5713_09515	COG1879	ABC-type sugar transport system periplasmic component
K5713_09520	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5713_09530	COG0673	inositol 2-dehydrogenase activity
K5713_09540	COG0673	inositol 2-dehydrogenase activity
K5713_09545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K5713_09565	COG3718	enzyme involved in inositol metabolism
K5713_09570	COG3962	Belongs to the TPP enzyme family
K5713_09580	COG4604	ABC transporter, ATP-binding protein
K5713_09585	COG4605	iron ion homeostasis
K5713_09590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5713_09595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5713_09600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5713_09605	COG0673	inositol 2-dehydrogenase activity
K5713_09615	COG1175	transmembrane transport
K5713_09620	COG0395	ABC-type sugar transport system, permease component
K5713_09625	COG1063	alcohol dehydrogenase
K5713_09630	COG0156	8-amino-7-oxononanoate synthase activity
K5713_09640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5713_09640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5713_09645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5713_09650	COG1904	glucuronate isomerase
K5713_09665	COG3142	Participates in the control of copper homeostasis
K5713_09680	COG1940	carbohydrate kinase activity
K5713_09690	COG0601	transmembrane transport
K5713_09695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5713_09705	COG1940	carbohydrate kinase activity
K5713_09710	COG1846	Transcriptional regulator
K5713_09710	COG1940	carbohydrate kinase activity
K5713_09720	COG1175	transmembrane transport
K5713_09800	COG1132	(ABC) transporter
K5713_09805	COG1132	(ABC) transporter
K5713_09805	COG2375	cellular response to nickel ion
K5713_09810	COG1129	ABC transporter
K5713_09815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K5713_09830	COG0471	metal ion transport
K5713_09870	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5713_09880	COG1879	ABC-type sugar transport system periplasmic component
K5713_09890	COG1070	Carbohydrate kinase
K5713_09920	COG1252	NADH dehydrogenase
K5713_09930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K5713_09975	COG1643	Atp-dependent helicase
K5713_09990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5713_10020	COG0577	efflux transmembrane transporter activity
K5713_10025	COG1136	(ABC) transporter
K5713_10040	COG0745	RESPONSE REGULATOR receiver
K5713_10045	COG2205	protein histidine kinase activity
K5713_10050	COG0343	queuine tRNA-ribosyltransferase activity
K5713_10060	COG1428	Deoxynucleoside kinase
K5713_10100	COG0656	L-ascorbic acid biosynthetic process
K5713_10105	COG0351	phosphomethylpyrimidine kinase
K5713_10115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5713_10125	COG2814	Major facilitator Superfamily
K5713_10130	COG0305	Participates in initiation and elongation during chromosome replication
K5713_10150	COG0359	binds to the 23S rRNA
K5713_10155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5713_10165	COG0360	Binds together with S18 to 16S ribosomal RNA
K5713_10170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5713_10175	COG0628	permease
K5713_10185	COG0617	tRNA 3'-terminal CCA addition
K5713_10205	COG0492	ferredoxin-NADP+ reductase activity
K5713_10210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5713_10215	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5713_10225	COG1192	Involved in chromosome partitioning
K5713_10230	COG0357	Ribosomal RNA small subunit methyltransferase G
K5713_10240	COG0706	membrane insertase activity
K5713_10245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5713_10250	COG0594	ribonuclease P activity
K5713_10255	COG0230	Belongs to the bacterial ribosomal protein bL34 family