locus-tag	class	description
M1F27_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M1F27_00010	COG0592	DNA-directed DNA polymerase activity
M1F27_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1F27_00025	COG0187	DNA topoisomerase II activity
M1F27_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1F27_00075	COG0457	Tetratricopeptide repeat
M1F27_00075	COG0705	Rhomboid family
M1F27_00085	COG3764	Sortase (surface protein transpeptidase)
M1F27_00115	COG1716	ATPase activity
M1F27_00120	COG1716	ATPase activity
M1F27_00120	COG1131	(ABC) transporter
M1F27_00120	COG0842	Transport permease protein
M1F27_00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1F27_00155	COG1854	S-ribosylhomocysteine lyase activity
M1F27_00170	COG1780	Probably involved in ribonucleotide reductase function
M1F27_00175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1F27_00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1F27_00190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1F27_00195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1F27_00210	COG0395	ABC-type sugar transport system, permease component
M1F27_00215	COG1175	transmembrane transport
M1F27_00235	COG2072	flavoprotein involved in K transport
M1F27_00245	COG1643	Atp-dependent helicase
M1F27_00250	COG2197	response regulator
M1F27_00255	COG4585	Histidine kinase
M1F27_00265	COG1131	(ABC) transporter
M1F27_00275	COG1136	(ABC) transporter
M1F27_00285	COG2197	response regulator
M1F27_00295	COG1328	CTP reductase activity
M1F27_00315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M1F27_00320	COG1414	Transcriptional regulator
M1F27_00325	COG0246	Mannitol dehydrogenase
M1F27_00330	COG1312	Catalyzes the dehydration of D-mannonate
M1F27_00335	COG0800	Aldolase
M1F27_00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F27_00345	COG2226	methyltransferase
M1F27_00355	COG1120	ATPase activity
M1F27_00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_00380	COG1132	(ABC) transporter
M1F27_00385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1F27_00390	COG1609	Transcriptional regulator
M1F27_00405	COG1175	transmembrane transport
M1F27_00410	COG0395	ABC-type sugar transport system, permease component
M1F27_00435	COG1487	ribonuclease activity
M1F27_00450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M1F27_00480	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F27_00485	COG1879	ABC-type sugar transport system periplasmic component
M1F27_00490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M1F27_00490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M1F27_00520	COG0561	phosphatase activity
M1F27_00525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1F27_00540	COG0077	Prephenate dehydratase
M1F27_00565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1F27_00585	COG4868	Belongs to the UPF0371 family
M1F27_00590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1F27_00650	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1F27_00660	COG0315	cyclic pyranopterin monophosphate synthase activity
M1F27_00670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1F27_00695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1F27_00730	COG0596	Alpha beta hydrolase
M1F27_00780	COG3655	Transcriptional regulator
M1F27_00790	COG2890	protein-(glutamine-N5) methyltransferase activity
M1F27_00790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1F27_00795	COG1754	DNA topoisomerase type I activity
M1F27_00795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1F27_00800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1F27_00805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1F27_00865	COG0717	Belongs to the dCTP deaminase family
M1F27_00870	COG2111	Na H antiporter
M1F27_00870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1F27_00875	COG1006	Multisubunit Na H antiporter MnhC subunit
M1F27_00880	COG0651	ATP synthesis coupled electron transport
M1F27_00910	COG4149	molybdate abc transporter
M1F27_00915	COG3842	ATPase activity
M1F27_00930	COG0662	Cupin 2, conserved barrel domain protein
M1F27_00970	COG1940	carbohydrate kinase activity
M1F27_00975	COG0390	transport system, permease component
M1F27_00985	COG1505	serine-type exopeptidase activity
M1F27_00995	COG0437	4 iron, 4 sulfur cluster binding
M1F27_01000	COG0243	molybdopterin cofactor binding
M1F27_01005	COG1937	Protein conserved in bacteria
M1F27_01010	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1F27_01020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M1F27_01025	COG0540	Belongs to the ATCase OTCase family
M1F27_01030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M1F27_01035	COG0284	orotidine-5'-phosphate decarboxylase activity
M1F27_01040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1F27_01045	COG0167	dihydroorotate dehydrogenase activity
M1F27_01050	COG0443	Heat shock 70 kDa protein
M1F27_01055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M1F27_01060	COG0484	heat shock protein binding
M1F27_01085	COG0584	glycerophosphoryl diester phosphodiesterase
M1F27_01095	COG1506	peptidase
M1F27_01095	COG0823	Involved in the tonB-independent uptake of proteins
M1F27_01105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1F27_01135	COG0300	oxidoreductase activity
M1F27_01150	COG0494	nUDIX hydrolase
M1F27_01165	COG0191	fructose-bisphosphate aldolase activity
M1F27_01175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1F27_01180	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M1F27_01185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1F27_01190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1F27_01220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1F27_01250	COG0039	L-malate dehydrogenase activity
M1F27_01255	COG0728	peptidoglycan biosynthetic process
M1F27_01280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1F27_01305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M1F27_01310	COG0406	alpha-ribazole phosphatase activity
M1F27_01310	COG0494	nUDIX hydrolase
M1F27_01330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1F27_01335	COG0306	phosphate transporter
M1F27_01345	COG1115	amino acid carrier protein
M1F27_01355	COG0737	Belongs to the 5'-nucleotidase family
M1F27_01365	COG3485	protocatechuate 3,4-dioxygenase
M1F27_01370	COG0354	folic acid binding
M1F27_01380	COG1490	D-aminoacyl-tRNA deacylase activity
M1F27_01400	COG0738	Major facilitator superfamily
M1F27_01405	COG2390	Transcriptional regulator
M1F27_01425	COG1349	DNA-binding transcription factor activity
M1F27_01445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1F27_01450	COG2376	Dihydroxyacetone kinase
M1F27_01460	COG0698	ribose 5-phosphate isomerase
M1F27_01465	COG0730	response to heat
M1F27_01470	COG0641	radical SAM
M1F27_01475	COG2814	Major facilitator Superfamily
M1F27_01480	COG1609	Transcriptional regulator
M1F27_01485	COG3119	arylsulfatase activity
M1F27_01495	COG0395	ABC-type sugar transport system, permease component
M1F27_01510	COG1501	Belongs to the glycosyl hydrolase 31 family
M1F27_01520	COG1349	DNA-binding transcription factor activity
M1F27_01530	COG1175	transmembrane transport
M1F27_01535	COG0395	ABC-type sugar transport system, permease component
M1F27_01560	COG2115	Belongs to the xylose isomerase family
M1F27_01565	COG1070	Carbohydrate kinase
M1F27_01570	COG4213	ABC transporter substrate-binding protein
M1F27_01580	COG4214	carbohydrate transport
M1F27_01585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M1F27_01590	COG1757	Na H antiporter
M1F27_01600	COG3250	beta-galactosidase activity
M1F27_01610	COG0395	ABC-type sugar transport system, permease component
M1F27_01620	COG1609	Transcriptional regulator
M1F27_01630	COG0395	ABC-type sugar transport system, permease component
M1F27_01635	COG1175	transmembrane transport
M1F27_01650	COG3250	beta-galactosidase activity
M1F27_01655	COG1609	Transcriptional regulator
M1F27_01665	COG2610	gluconate transmembrane transporter activity
M1F27_01675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1F27_01685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M1F27_01690	COG3250	beta-galactosidase activity
M1F27_01695	COG1869	D-ribose catabolic process
M1F27_01700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F27_01705	COG1879	ABC-type sugar transport system periplasmic component
M1F27_01710	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F27_01715	COG1129	ABC transporter
M1F27_01720	COG1609	Transcriptional regulator
M1F27_01725	COG2226	methyltransferase
M1F27_01730	COG1116	anion transmembrane transporter activity
M1F27_01730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1F27_01755	COG0737	Belongs to the 5'-nucleotidase family
M1F27_01765	COG1609	Transcriptional regulator
M1F27_01770	COG2271	Major facilitator Superfamily
M1F27_01775	COG1285	pathogenesis
M1F27_01800	COG1131	(ABC) transporter
M1F27_01835	COG1715	Restriction endonuclease
M1F27_01850	COG2963	transposase activity
M1F27_01875	COG1002	Type II restriction enzyme, methylase subunits
M1F27_01880	COG1061	Type III restriction enzyme res subunit
M1F27_01885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1F27_01930	COG1518	maintenance of DNA repeat elements
M1F27_01940	COG3609	addiction module antidote protein, CC2985 family
M1F27_01950	COG3620	sequence-specific DNA binding
M1F27_01955	COG0366	Alpha amylase catalytic
M1F27_01960	COG0395	ABC-type sugar transport system, permease component
M1F27_01965	COG1175	transmembrane transport
M1F27_01980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F27_01980	COG0574	Belongs to the PEP-utilizing enzyme family
M1F27_01985	COG0247	lactate metabolic process
M1F27_01985	COG0277	FAD linked oxidase domain protein
M1F27_01995	COG2267	carboxylic ester hydrolase activity
M1F27_02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1F27_02005	COG0791	NLP P60 protein
M1F27_02010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1F27_02025	COG0037	tRNA processing
M1F27_02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1F27_02040	COG0302	gtp cyclohydrolase
M1F27_02050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1F27_02070	COG1609	Transcriptional regulator
M1F27_02090	COG3250	beta-galactosidase activity
M1F27_02100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F27_02100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1F27_02105	COG1461	Dihydroxyacetone kinase
M1F27_02110	COG2376	Dihydroxyacetone kinase
M1F27_02120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M1F27_02125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M1F27_02135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M1F27_02140	COG2409	Drug exporters of the RND superfamily
M1F27_02145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1F27_02150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1F27_02165	COG0247	lactate metabolic process
M1F27_02170	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M1F27_02175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1F27_02190	COG1194	a g-specific adenine glycosylase
M1F27_02200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M1F27_02205	COG0569	domain protein
M1F27_02210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1F27_02225	COG1846	Transcriptional regulator
M1F27_02230	COG0406	alpha-ribazole phosphatase activity
M1F27_02255	COG0395	ABC-type sugar transport system, permease component
M1F27_02260	COG1175	transmembrane transport
M1F27_02270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M1F27_02275	COG4948	Mandelate Racemase Muconate Lactonizing
M1F27_02280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M1F27_02285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1F27_02290	COG1169	isochorismate synthase
M1F27_02295	COG2226	methyltransferase
M1F27_02300	COG0644	oxidoreductase
M1F27_02310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F27_02315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F27_02320	COG0649	NAD binding
M1F27_02330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1F27_02335	COG1034	ATP synthesis coupled electron transport
M1F27_02340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1F27_02345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F27_02350	COG0839	Belongs to the complex I subunit 6 family
M1F27_02355	COG0713	ATP synthesis coupled electron transport
M1F27_02370	COG1007	ATP synthesis coupled electron transport
M1F27_02375	COG0142	geranyltranstransferase activity
M1F27_02380	COG0653	protein targeting
M1F27_02420	COG0419	ATPase involved in DNA repair
M1F27_02425	COG0420	3'-5' exonuclease activity
M1F27_02430	COG0483	inositol monophosphate 1-phosphatase activity
M1F27_02435	COG1162	GTPase activity
M1F27_02440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1F27_02460	COG0657	acetylesterase activity
M1F27_02475	COG0601	transmembrane transport
M1F27_02480	COG0444	Belongs to the ABC transporter superfamily
M1F27_02485	COG4608	Belongs to the ABC transporter superfamily
M1F27_02490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1F27_02500	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M1F27_02505	COG0363	glucosamine-6-phosphate deaminase activity
M1F27_02515	COG1595	DNA-templated transcription, initiation
M1F27_02530	COG0791	NLP P60 protein
M1F27_02530	COG1388	LysM domain
M1F27_02530	COG3103	Sh3 type 3 domain protein
M1F27_02540	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1F27_02540	COG0567	Dehydrogenase, E1 component
M1F27_02545	COG1253	flavin adenine dinucleotide binding
M1F27_02555	COG0739	heme binding
M1F27_02560	COG0584	glycerophosphoryl diester phosphodiesterase
M1F27_02590	COG0018	arginyl-trna synthetase
M1F27_02600	COG0460	homoserine dehydrogenase
M1F27_02605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1F27_02610	COG0083	homoserine kinase activity
M1F27_02625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M1F27_02640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1F27_02650	COG0356	it plays a direct role in the translocation of protons across the membrane
M1F27_02655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1F27_02660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M1F27_02665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1F27_02670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M1F27_02675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M1F27_02680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M1F27_02685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M1F27_02695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M1F27_02740	COG1609	Transcriptional regulator
M1F27_02750	COG1175	transmembrane transport
M1F27_02755	COG3833	ABC-type maltose transport systems, permease component
M1F27_02765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M1F27_02770	COG3281	Trehalose synthase
M1F27_02775	COG0366	Alpha amylase catalytic
M1F27_02780	COG0366	Alpha amylase catalytic
M1F27_02805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1F27_02810	COG0058	SHG alpha-glucan phosphorylase activity
M1F27_02815	COG0180	Tryptophanyl-tRNA synthetase
M1F27_02845	COG3480	Lon protease (S16) C-terminal proteolytic domain
M1F27_02855	COG1615	UPF0182 protein
M1F27_02860	COG1470	cell adhesion involved in biofilm formation
M1F27_02860	COG0366	Alpha amylase catalytic
M1F27_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F27_02885	COG1131	(ABC) transporter
M1F27_02895	COG0387	Pfam Sodium calcium exchanger
M1F27_02905	COG1053	succinate dehydrogenase
M1F27_02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M1F27_02965	COG4585	Histidine kinase
M1F27_02970	COG2135	peptidase activity
M1F27_02975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M1F27_02990	COG1397	ADP-ribosylglycohydrolase
M1F27_03000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F27_03005	COG3177	Filamentation induced by cAMP protein fic
M1F27_03015	COG1404	Belongs to the peptidase S8 family
M1F27_03020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1F27_03025	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1F27_03030	COG0154	amidase activity
M1F27_03035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1F27_03085	COG0129	dihydroxy-acid dehydratase activity
M1F27_03090	COG2985	domain, Protein
M1F27_03090	COG0569	domain protein
M1F27_03100	COG0440	acetolactate synthase activity
M1F27_03105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1F27_03125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1F27_03155	COG0438	transferase activity, transferring glycosyl groups
M1F27_03160	COG4750	Nucleotidyl transferase
M1F27_03165	COG3475	LICD family
M1F27_03170	COG1216	Glycosyl transferase, family 2
M1F27_03170	COG1442	glycosyl transferase family 8
M1F27_03195	COG2244	polysaccharide biosynthetic process
M1F27_03200	COG0463	Glycosyl transferase, family 2
M1F27_03230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1F27_03260	COG1946	Acyl-CoA thioesterase
M1F27_03275	COG0519	Catalyzes the synthesis of GMP from XMP
M1F27_03285	COG2354	Protein conserved in bacteria
M1F27_03290	COG3590	peptidase
M1F27_03300	COG1045	serine acetyltransferase
M1F27_03310	COG1739	Uncharacterized protein family UPF0029
M1F27_03325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1F27_03340	COG0488	(ABC) transporter
M1F27_03355	COG1609	Transcriptional regulator
M1F27_03360	COG3250	beta-galactosidase activity
M1F27_03380	COG0667	Aldo Keto reductase
M1F27_03385	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1F27_03390	COG0740	serine-type endopeptidase activity
M1F27_03395	COG0740	serine-type endopeptidase activity
M1F27_03400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M1F27_03405	COG1605	Chorismate mutase
M1F27_03405	COG0287	Prephenate dehydrogenase
M1F27_03425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1F27_03440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1F27_03445	COG0285	dihydrofolate synthase activity
M1F27_03450	COG0105	UTP biosynthetic process
M1F27_03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1F27_03495	COG0228	four-way junction DNA binding
M1F27_03500	COG1837	Belongs to the UPF0109 family
M1F27_03505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1F27_03515	COG0335	large ribosomal subunit rRNA binding
M1F27_03520	COG0681	Belongs to the peptidase S26 family
M1F27_03525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1F27_03550	COG4974	Belongs to the 'phage' integrase family
M1F27_03555	COG1388	LysM domain
M1F27_03555	COG4942	peptidase
M1F27_03560	COG2860	membrane
M1F27_03565	COG0052	Belongs to the universal ribosomal protein uS2 family
M1F27_03570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M1F27_03580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1F27_03585	COG0644	oxidoreductase
M1F27_03610	COG0233	cytoplasmic translational termination
M1F27_03620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M1F27_03630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1F27_03635	COG0750	zinc metalloprotease
M1F27_03640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M1F27_03650	COG0442	prolyl-tRNA aminoacylation
M1F27_03660	COG0779	Required for maturation of 30S ribosomal subunits
M1F27_03675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M1F27_03680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M1F27_03685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1F27_03690	COG3852	Histidine kinase
M1F27_03695	COG0745	RESPONSE REGULATOR receiver
M1F27_03700	COG2271	Major facilitator Superfamily
M1F27_03710	COG3842	ATPase activity
M1F27_03740	COG0842	Transport permease protein
M1F27_03740	COG1129	ABC transporter
M1F27_03755	COG1185	polyribonucleotide nucleotidyltransferase activity
M1F27_03760	COG0612	Peptidase, M16
M1F27_03765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M1F27_03770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1F27_03785	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1F27_03790	COG1674	ftsk spoiiie
M1F27_03805	COG1546	Belongs to the CinA family
M1F27_03805	COG1058	Belongs to the CinA family
M1F27_03810	COG1396	sequence-specific DNA binding
M1F27_03820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M1F27_03825	COG2137	regulation of response to DNA damage stimulus
M1F27_03830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1F27_03835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M1F27_03845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1F27_03855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1F27_03865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1F27_03870	COG0318	PFAM AMP-dependent synthetase and ligase
M1F27_03875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1F27_03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1F27_03905	COG2001	Belongs to the MraZ family
M1F27_03910	COG0275	rRNA processing
M1F27_03920	COG0768	penicillin binding
M1F27_03925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1F27_03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1F27_03935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1F27_03940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1F27_03945	COG0772	Belongs to the SEDS family
M1F27_03950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1F27_03955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1F27_03965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1F27_03975	COG1799	cell septum assembly
M1F27_03990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M1F27_04005	COG0587	DNA-directed DNA polymerase activity
M1F27_04020	COG0735	belongs to the Fur family
M1F27_04025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F27_04030	COG1121	(ABC) transporter
M1F27_04040	COG0423	glycine-tRNA ligase activity
M1F27_04065	COG0358	DNA primase activity
M1F27_04075	COG0805	protein transport
M1F27_04080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1F27_04115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_04120	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M1F27_04155	COG1090	epimerase
M1F27_04175	COG0009	L-threonylcarbamoyladenylate synthase
M1F27_04195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M1F27_04220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1F27_04225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1F27_04230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1F27_04250	COG1940	carbohydrate kinase activity
M1F27_04265	COG0174	glutamine synthetase
M1F27_04270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1F27_04280	COG0174	glutamine synthetase
M1F27_04300	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1F27_04305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1F27_04315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1F27_04330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1F27_04370	COG0205	6-phosphofructokinase activity
M1F27_04375	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M1F27_04380	COG0515	serine threonine protein kinase
M1F27_04380	COG2815	serine threonine protein kinase
M1F27_04395	COG0142	geranyltranstransferase activity
M1F27_04410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1F27_04415	COG1199	ATP-dependent helicase activity
M1F27_04415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1F27_04425	COG0187	DNA topoisomerase II activity
M1F27_04440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1F27_04480	COG0569	domain protein
M1F27_04495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1F27_04505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M1F27_04570	COG2197	response regulator
M1F27_04575	COG1760	l-serine dehydratase
M1F27_04580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1F27_04585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1F27_04595	COG0438	transferase activity, transferring glycosyl groups
M1F27_04605	COG1051	belongs to the nudix hydrolase family
M1F27_04610	COG0217	transcriptional regulatory protein
M1F27_04615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M1F27_04620	COG0632	four-way junction helicase activity
M1F27_04625	COG2255	four-way junction helicase activity
M1F27_04635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1F27_04640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1F27_04645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1F27_04650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1F27_04660	COG1196	nuclear chromosome segregation
M1F27_04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1F27_04670	COG0124	histidyl-tRNA synthetase
M1F27_04675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1F27_04680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1F27_04700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M1F27_04715	COG2409	Drug exporters of the RND superfamily
M1F27_04725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1F27_04735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1F27_04740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1F27_04760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1F27_04770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M1F27_04775	COG2217	Heavy metal translocating P-type atpase
M1F27_04780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1F27_04785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1F27_04790	COG0505	Belongs to the CarA family
M1F27_04795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1F27_04805	COG0194	GDP metabolic process
M1F27_04810	COG1758	RNA polymerase activity
M1F27_04820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M1F27_04825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1F27_04830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1F27_04840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1F27_04845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1F27_04850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1F27_04855	COG0140	phosphoribosyl-ATP diphosphatase activity
M1F27_04860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1F27_04890	COG4581	dead DEAH box helicase
M1F27_04900	COG1216	Glycosyl transferase, family 2
M1F27_04940	COG0205	6-phosphofructokinase activity
M1F27_04945	COG1160	GTP binding
M1F27_04950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M1F27_04965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1F27_04990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1F27_05005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1F27_05010	COG0149	triose-phosphate isomerase activity
M1F27_05015	COG0126	phosphoglycerate kinase activity
M1F27_05020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1F27_05025	COG1481	regulation of sporulation
M1F27_05040	COG0322	excinuclease ABC activity
M1F27_05045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1F27_05065	COG0556	nucleotide-excision repair
M1F27_05070	COG0237	dephospho-CoA kinase activity
M1F27_05075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M1F27_05080	COG1136	(ABC) transporter
M1F27_05120	COG0469	pyruvate kinase activity
M1F27_05125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M1F27_05130	COG0134	indole-3-glycerol-phosphate synthase activity
M1F27_05140	COG0107	imidazoleglycerol-phosphate synthase activity
M1F27_05155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M1F27_05165	COG4122	O-methyltransferase activity
M1F27_05170	COG1222	aaa ATPase
M1F27_05190	COG1968	undecaprenyl-diphosphatase activity
M1F27_05205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1F27_05215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1F27_05215	COG0519	Catalyzes the synthesis of GMP from XMP
M1F27_05240	COG0587	DNA-directed DNA polymerase activity
M1F27_05255	COG1881	PFAM PEBP family protein
M1F27_05290	COG1119	ATPase activity
M1F27_05295	COG0297	glycogen (starch) synthase activity
M1F27_05305	COG1136	(ABC) transporter
M1F27_05315	COG3830	Belongs to the UPF0237 family
M1F27_05315	COG0560	Phosphoserine phosphatase
M1F27_05325	COG0488	(ABC) transporter
M1F27_05330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1F27_05335	COG2151	metal-sulfur cluster biosynthetic enzyme
M1F27_05350	COG0396	ATPase activity
M1F27_05380	COG0728	peptidoglycan biosynthetic process
M1F27_05400	COG0497	DNA recombination
M1F27_05405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1F27_05420	COG0647	UMP catabolic process
M1F27_05450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F27_05455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F27_05460	COG1121	(ABC) transporter
M1F27_05465	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1F27_05470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1F27_05485	COG1476	TRANSCRIPTIONal
M1F27_05495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1F27_05500	COG1438	arginine binding
M1F27_05515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M1F27_05520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1F27_05535	COG1902	pentaerythritol trinitrate reductase activity
M1F27_05540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1F27_05555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M1F27_05570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1F27_05575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1F27_05585	COG0131	Imidazoleglycerol-phosphate dehydratase
M1F27_05595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1F27_05600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1F27_05605	COG1381	Involved in DNA repair and RecF pathway recombination
M1F27_05610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1F27_05645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M1F27_05655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1F27_05660	COG0484	heat shock protein binding
M1F27_05665	COG1420	regulation of RNA biosynthetic process
M1F27_05685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1F27_05690	COG0481	GTPase activity
M1F27_05715	COG0268	Binds directly to 16S ribosomal RNA
M1F27_05720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M1F27_05725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M1F27_05745	COG0433	COG0433 Predicted ATPase
M1F27_05760	COG0495	leucyl-tRNA aminoacylation
M1F27_05785	COG0813	purine-nucleoside phosphorylase activity
M1F27_05795	COG1435	thymidine kinase activity
M1F27_05815	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1F27_05825	COG1121	(ABC) transporter
M1F27_05830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F27_05850	COG0671	phosphoesterase, PA-phosphatase related
M1F27_05870	COG1113	amino acid transport
M1F27_05875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1F27_05875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1F27_05885	COG2011	ABC-type metal ion transport system permease component
M1F27_05890	COG1464	Belongs to the NlpA lipoprotein family
M1F27_05895	COG1113	amino acid transport
M1F27_05905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1F27_05910	COG2186	Transcriptional regulator
M1F27_05915	COG0477	Major facilitator Superfamily
M1F27_05925	COG0826	peptidase U32
M1F27_05930	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M1F27_05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F27_05980	COG0726	polysaccharide deacetylase
M1F27_05985	COG0133	tryptophan synthase activity
M1F27_05990	COG1609	Transcriptional regulator
M1F27_06000	COG0738	Major facilitator superfamily
M1F27_06005	COG0235	Class ii aldolase
M1F27_06050	COG0406	alpha-ribazole phosphatase activity
M1F27_06055	COG0799	negative regulation of ribosome biogenesis
M1F27_06065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M1F27_06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1F27_06080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1F27_06090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M1F27_06095	COG1530	ribonuclease E activity
M1F27_06100	COG1271	oxidase subunit
M1F27_06105	COG1294	oxidase, subunit
M1F27_06110	COG4988	ABC transporter
M1F27_06115	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1F27_06125	COG1132	(ABC) transporter
M1F27_06130	COG1132	(ABC) transporter
M1F27_06150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M1F27_06155	COG0571	ribonuclease III activity
M1F27_06170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M1F27_06185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1F27_06195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1F27_06205	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1F27_06210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1F27_06230	COG0438	transferase activity, transferring glycosyl groups
M1F27_06245	COG4975	Glucose uptake
M1F27_06250	COG0339	signal peptide processing
M1F27_06305	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1F27_06310	COG1022	Amp-dependent synthetase and ligase
M1F27_06315	COG1022	Amp-dependent synthetase and ligase
M1F27_06340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M1F27_06345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M1F27_06355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1F27_06365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1F27_06390	COG2985	domain, Protein
M1F27_06390	COG0569	domain protein
M1F27_06405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1F27_06485	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1F27_06505	COG2177	Part of the ABC transporter FtsEX involved in
M1F27_06510	COG2884	Cell division ATP-binding protein ftsE
M1F27_06515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M1F27_06575	COG0513	Belongs to the DEAD box helicase family
M1F27_06580	COG2095	MarC family integral membrane protein
M1F27_06590	COG0006	proline dipeptidase activity
M1F27_06595	COG2239	Acts as a magnesium transporter
M1F27_06620	COG1611	Belongs to the LOG family
M1F27_06630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1F27_06635	COG1309	transcriptional regulator
M1F27_06640	COG2814	Major facilitator Superfamily
M1F27_06645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M1F27_06665	COG1079	Belongs to the binding-protein-dependent transport system permease family
M1F27_06670	COG4603	Belongs to the binding-protein-dependent transport system permease family
M1F27_06675	COG3845	ABC transporter
M1F27_06680	COG1744	ABC transporter substrate-binding protein PnrA-like
M1F27_06700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M1F27_06705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1F27_06715	COG1268	BioY protein
M1F27_06725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1F27_06730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1F27_06735	COG4770	biotin carboxylase activity
M1F27_06755	COG0644	oxidoreductase
M1F27_06760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1F27_06775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1F27_06780	COG2271	Major facilitator Superfamily
M1F27_06785	COG2030	dehydratase
M1F27_06825	COG0039	L-malate dehydrogenase activity
M1F27_06835	COG0166	Belongs to the GPI family
M1F27_06840	COG0205	6-phosphofructokinase activity
M1F27_06870	COG0045	succinate-CoA ligase (ADP-forming) activity
M1F27_06875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M1F27_06875	COG2755	lipolytic protein G-D-S-L family
M1F27_06930	COG4974	Belongs to the 'phage' integrase family
M1F27_06955	COG0857	belongs to the CobB CobQ family
M1F27_06955	COG0280	phosphate acetyltransferase
M1F27_06960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1F27_06975	COG1136	(ABC) transporter
M1F27_06985	COG0114	fumarate hydratase activity
M1F27_06990	COG0516	GMP reductase activity
M1F27_07010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1F27_07015	COG0151	Belongs to the GarS family
M1F27_07020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1F27_07025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1F27_07030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1F27_07035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1F27_07040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1F27_07050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M1F27_07060	COG0428	transporter
M1F27_07065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M1F27_07070	COG0733	neurotransmitter:sodium symporter activity
M1F27_07080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1F27_07085	COG1053	succinate dehydrogenase
M1F27_07110	COG0802	atpase or kinase
M1F27_07115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1F27_07125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1F27_07130	COG1072	(Pantothenic acid kinase))
M1F27_07140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1F27_07145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1F27_07155	COG4720	Psort location CytoplasmicMembrane, score
M1F27_07160	COG1122	ATPase activity
M1F27_07180	COG0101	tRNA pseudouridine synthase activity
M1F27_07185	COG1940	carbohydrate kinase activity
M1F27_07195	COG0765	amino acid transport
M1F27_07205	COG0789	Transcriptional regulator
M1F27_07215	COG0203	ribosomal protein L17
M1F27_07220	COG0202	RNA polymerase activity
M1F27_07230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1F27_07235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1F27_07240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M1F27_07250	COG0563	adenylate kinase activity
M1F27_07260	COG0200	Binds to the 23S rRNA
M1F27_07265	COG1841	ribosomal large subunit assembly
M1F27_07270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1F27_07280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1F27_07285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1F27_07290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1F27_07295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1F27_07300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1F27_07305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1F27_07320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1F27_07325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1F27_07330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1F27_07335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1F27_07340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1F27_07345	COG0089	rRNA binding
M1F27_07350	COG0088	Forms part of the polypeptide exit tunnel
M1F27_07355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1F27_07360	COG0051	transcription antitermination factor activity, RNA binding
M1F27_07365	COG0546	phosphoglycolate phosphatase activity
M1F27_07375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1F27_07380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1F27_07385	COG0049	tRNA binding
M1F27_07390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M1F27_07395	COG0833	amino acid
M1F27_07400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1F27_07405	COG0085	RNA polymerase activity
M1F27_07410	COG0222	ribosome binding
M1F27_07415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1F27_07425	COG0081	regulation of translation
M1F27_07430	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1F27_07435	COG0250	Participates in transcription elongation, termination and antitermination
M1F27_07450	COG0436	Aminotransferase
M1F27_07460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1F27_07475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1F27_07485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1F27_07505	COG1666	GTP binding
M1F27_07515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M1F27_07520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1F27_07525	COG5401	PFAM Sporulation and spore germination
M1F27_07530	COG5002	protein histidine kinase activity
M1F27_07530	COG5000	phosphorelay sensor kinase activity
M1F27_07535	COG0745	RESPONSE REGULATOR receiver
M1F27_07555	COG0714	Associated with various cellular activities
M1F27_07600	COG0483	inositol monophosphate 1-phosphatase activity
M1F27_07615	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1F27_07710	COG0673	inositol 2-dehydrogenase activity
M1F27_07735	COG1088	dTDP-glucose 4,6-dehydratase activity
M1F27_07750	COG1316	TRANSCRIPTIONal
M1F27_07755	COG1316	TRANSCRIPTIONal
M1F27_07765	COG0642	Histidine kinase
M1F27_07770	COG0745	RESPONSE REGULATOR receiver
M1F27_07785	COG0424	maF-like protein
M1F27_07820	COG1217	gtp-binding protein TYPA
M1F27_07830	COG1132	(ABC) transporter
M1F27_07870	COG0321	lipoyl(octanoyl) transferase activity
M1F27_07875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1F27_07885	COG1362	aminopeptidase activity
M1F27_07900	COG2838	Isocitrate dehydrogenase
M1F27_07905	COG2391	methyltransferase activity
M1F27_07910	COG0425	Belongs to the sulfur carrier protein TusA family
M1F27_07915	COG0366	Alpha amylase catalytic
M1F27_07920	COG1501	Belongs to the glycosyl hydrolase 31 family
M1F27_07930	COG0395	ABC-type sugar transport system, permease component
M1F27_07935	COG1175	transmembrane transport
M1F27_07940	COG1846	Transcriptional regulator
M1F27_07940	COG1940	carbohydrate kinase activity
M1F27_07965	COG4608	Belongs to the ABC transporter superfamily
M1F27_07970	COG0444	Belongs to the ABC transporter superfamily
M1F27_07975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1F27_07990	COG2116	formate transmembrane transporter activity
M1F27_08000	COG0242	peptide deformylase activity
M1F27_08005	COG1970	mechanosensitive ion channel activity
M1F27_08030	COG1846	Transcriptional regulator
M1F27_08030	COG0456	acetyltransferase
M1F27_08035	COG1780	Probably involved in ribonucleotide reductase function
M1F27_08045	COG0431	NADPH-dependent FMN reductase
M1F27_08050	COG3226	Transcriptional regulator
M1F27_08055	COG0477	Major facilitator Superfamily
M1F27_08065	COG1834	amidinotransferase
M1F27_08070	COG0549	Belongs to the carbamate kinase family
M1F27_08075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1F27_08095	COG0395	ABC-type sugar transport system, permease component
M1F27_08110	COG0366	Alpha amylase catalytic
M1F27_08125	COG0477	Major facilitator Superfamily
M1F27_08180	COG0012	GTP binding
M1F27_08185	COG1322	Protein conserved in bacteria
M1F27_08190	COG1162	GTPase activity
M1F27_08205	COG4555	ABC transporter
M1F27_08225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M1F27_08235	COG1722	exodeoxyribonuclease VII activity
M1F27_08240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F27_08245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1F27_08255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1F27_08260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1F27_08265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1F27_08280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1F27_08285	COG1012	belongs to the aldehyde dehydrogenase family
M1F27_08300	COG1131	(ABC) transporter
M1F27_08305	COG1725	Transcriptional regulator
M1F27_08330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1F27_08350	COG0148	phosphopyruvate hydratase activity
M1F27_08365	COG0193	aminoacyl-tRNA hydrolase activity
M1F27_08370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M1F27_08380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1F27_08390	COG1309	transcriptional regulator
M1F27_08405	COG4152	abc transporter atp-binding protein
M1F27_08410	COG1668	transmembrane transport
M1F27_08420	COG0488	(ABC) transporter
M1F27_08425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M1F27_08430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1F27_08440	COG0084	hydrolase, TatD family'
M1F27_08445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1F27_08450	COG1335	isochorismatase
M1F27_08470	COG2873	o-acetylhomoserine
M1F27_08490	COG1131	(ABC) transporter
M1F27_08505	COG2813	Specifically methylates the guanine in position
M1F27_08535	COG1620	l-lactate permease
M1F27_08540	COG0247	lactate metabolic process
M1F27_08550	COG1556	Lactate utilization protein
M1F27_08570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1F27_08575	COG2190	(PTS) system
M1F27_08580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1F27_08580	COG1263	PTS System
M1F27_08595	COG1051	belongs to the nudix hydrolase family
M1F27_08605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F27_08615	COG3711	transcriptional antiterminator
M1F27_08625	COG1511	domain protein
M1F27_08635	COG2848	UPF0210 protein
M1F27_08640	COG3830	Belongs to the UPF0237 family
M1F27_08655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1F27_08660	COG0254	rRNA binding
M1F27_08665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1F27_08670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1F27_08675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1F27_08690	COG0477	Major facilitator Superfamily
M1F27_08695	COG0657	acetylesterase activity
M1F27_08700	COG2188	Transcriptional regulator
M1F27_08705	COG1120	ATPase activity
M1F27_08710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_08715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_08720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M1F27_08735	COG0596	Alpha beta hydrolase
M1F27_08755	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1F27_08825	COG0791	NLP P60 protein
M1F27_08825	COG1388	LysM domain
M1F27_08835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M1F27_08840	COG2252	PERMEase
M1F27_08855	COG1278	Cold shock
M1F27_08865	COG1842	Phage shock protein A
M1F27_08875	COG0745	RESPONSE REGULATOR receiver
M1F27_08880	COG2205	protein histidine kinase activity
M1F27_08890	COG0300	oxidoreductase activity
M1F27_08905	COG0459	protein refolding
M1F27_08920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M1F27_08955	COG3842	ATPase activity
M1F27_08965	COG0673	inositol 2-dehydrogenase activity
M1F27_08975	COG1653	transport
M1F27_08980	COG1175	transmembrane transport
M1F27_09010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1F27_09025	COG1966	Carbon starvation protein
M1F27_09050	COG2233	PERMEase
M1F27_09065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1F27_09070	COG0215	cysteine-tRNA ligase activity
M1F27_09085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M1F27_09090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M1F27_09105	COG5002	protein histidine kinase activity
M1F27_09120	COG0588	phosphoglycerate mutase activity
M1F27_09165	COG1120	ATPase activity
M1F27_09170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_09195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1F27_09200	COG0667	Aldo Keto reductase
M1F27_09210	COG0710	3-dehydroquinate dehydratase activity
M1F27_09240	COG0714	Associated with various cellular activities
M1F27_09255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1F27_09260	COG1950	PFAM Membrane protein of
M1F27_09265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1F27_09270	COG0586	Pfam SNARE associated Golgi protein
M1F27_09300	COG1309	transcriptional regulator
M1F27_09310	COG1132	(ABC) transporter
M1F27_09310	COG2375	cellular response to nickel ion
M1F27_09315	COG1129	ABC transporter
M1F27_09330	COG1063	alcohol dehydrogenase
M1F27_09335	COG1609	Transcriptional regulator
M1F27_09340	COG2271	Major facilitator Superfamily
M1F27_09345	COG0483	inositol monophosphate 1-phosphatase activity
M1F27_09350	COG1879	ABC-type sugar transport system periplasmic component
M1F27_09355	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F27_09365	COG0673	inositol 2-dehydrogenase activity
M1F27_09375	COG0673	inositol 2-dehydrogenase activity
M1F27_09380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1F27_09400	COG3718	enzyme involved in inositol metabolism
M1F27_09405	COG3962	Belongs to the TPP enzyme family
M1F27_09415	COG4604	ABC transporter, ATP-binding protein
M1F27_09420	COG4605	iron ion homeostasis
M1F27_09425	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F27_09430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1F27_09435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1F27_09445	COG0673	inositol 2-dehydrogenase activity
M1F27_09455	COG1175	transmembrane transport
M1F27_09460	COG0395	ABC-type sugar transport system, permease component
M1F27_09465	COG1063	alcohol dehydrogenase
M1F27_09470	COG0156	8-amino-7-oxononanoate synthase activity
M1F27_09480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M1F27_09480	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M1F27_09485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M1F27_09490	COG1904	glucuronate isomerase
M1F27_09505	COG3142	Participates in the control of copper homeostasis
M1F27_09520	COG1940	carbohydrate kinase activity
M1F27_09530	COG0601	transmembrane transport
M1F27_09535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1F27_09545	COG1940	carbohydrate kinase activity
M1F27_09550	COG1846	Transcriptional regulator
M1F27_09550	COG1940	carbohydrate kinase activity
M1F27_09560	COG1175	transmembrane transport
M1F27_09590	COG2801	Transposase and inactivated derivatives
M1F27_09630	COG2801	Transposase and inactivated derivatives
M1F27_09635	COG1132	(ABC) transporter
M1F27_09640	COG2375	cellular response to nickel ion
M1F27_09640	COG1132	(ABC) transporter
M1F27_09645	COG1129	ABC transporter
M1F27_09650	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1F27_09665	COG0471	metal ion transport
M1F27_09705	COG1252	NADH dehydrogenase
M1F27_09715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M1F27_09755	COG1643	Atp-dependent helicase
M1F27_09770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1F27_09800	COG1136	(ABC) transporter
M1F27_09800	COG0577	efflux transmembrane transporter activity
M1F27_09805	COG1136	(ABC) transporter
M1F27_09820	COG0745	RESPONSE REGULATOR receiver
M1F27_09825	COG2205	protein histidine kinase activity
M1F27_09830	COG0343	queuine tRNA-ribosyltransferase activity
M1F27_09840	COG1428	Deoxynucleoside kinase
M1F27_09885	COG0351	phosphomethylpyrimidine kinase
M1F27_09895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1F27_09905	COG2814	Major facilitator Superfamily
M1F27_09910	COG0305	Participates in initiation and elongation during chromosome replication
M1F27_09930	COG0359	binds to the 23S rRNA
M1F27_09935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M1F27_09945	COG0360	Binds together with S18 to 16S ribosomal RNA
M1F27_09950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1F27_09955	COG0628	permease
M1F27_09965	COG0617	tRNA 3'-terminal CCA addition
M1F27_09985	COG0492	ferredoxin-NADP+ reductase activity
M1F27_09990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F27_09995	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1F27_10005	COG1192	Involved in chromosome partitioning
M1F27_10010	COG0357	Ribosomal RNA small subunit methyltransferase G
M1F27_10020	COG0706	membrane insertase activity
M1F27_10025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M1F27_10030	COG0594	ribonuclease P activity
M1F27_10035	COG0230	Belongs to the bacterial ribosomal protein bL34 family