locus-tag	class	description
DDE06_00010	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
DDE06_00045	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
DDE06_00050	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
DDE06_00055	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
DDE06_00060	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
DDE06_00070	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
DDE06_00080	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
DDE06_00085	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
DDE06_00095	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
DDE06_00100	ENOG41084BS	50S ribosomal protein L35
DDE06_00105	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
DDE06_00115	ENOG4108RWN	rrna methyltransferase
DDE06_00130	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
DDE06_00135	ENOG4108Z66	YbaK ebsC protein
DDE06_00140	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
DDE06_00155	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
DDE06_00160	ENOG4105CMR	udp-glucose 4-epimerase
DDE06_00170	ENOG4105VZ8	Transcriptional regulator
DDE06_00180	ENOG4108M15	ABC transporter
DDE06_00185	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
DDE06_00190	ENOG4107SIG	periplasmic solute binding protein
DDE06_00195	ENOG4105DIK	(ABC) transporter
DDE06_00200	ENOG4107RPQ	ABC transporter
DDE06_00205	ENOG4105CC5	ABC transporter
DDE06_00235	ENOG4105DSU	hydrolase
DDE06_00245	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
DDE06_00250	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
DDE06_00270	ENOG4105CJR	Integral membrane protein (MviN
DDE06_00300	ENOG4105C3K	feS assembly ATPase SufC
DDE06_00315	ENOG4105VG1	fes assembly suf system protein
DDE06_00320	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
DDE06_00325	ENOG4105C5H	ABC transporter
DDE06_00335	ENOG4105EAC	phosphoserine phosphatase
DDE06_00345	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_00350	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
DDE06_00355	ENOG4107QPH	glycogen) synthase
DDE06_00360	ENOG4105DKW	ABC transporter
DDE06_00390	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
DDE06_00395	ENOG4108V1U	phospholipid-binding protein
DDE06_00410	ENOG4105C0B	DNA polymerase III (alpha subunit)
DDE06_00435	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DDE06_00440	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
DDE06_00445	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
DDE06_00460	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
DDE06_00465	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
DDE06_00480	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
DDE06_00485	ENOG4105E5F	proteasome
DDE06_00490	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
DDE06_00495	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
DDE06_00510	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
DDE06_00515	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
DDE06_00520	ENOG4105DK0	Indole-3-glycerol phosphate synthase
DDE06_00525	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
DDE06_00530	ENOG4105CA9	Pyruvate kinase
DDE06_00555	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
DDE06_00565	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_00570	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
DDE06_00575	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
DDE06_00580	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
DDE06_00590	ENOG4105DHU	Bile acid
DDE06_00600	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
DDE06_00605	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
DDE06_00610	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
DDE06_00620	ENOG4105CIE	May be required for sporulation (By similarity)
DDE06_00625	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
DDE06_00630	ENOG4105BZA	Phosphoglycerate kinase
DDE06_00635	ENOG4105CP7	Triose-phosphate isomerase
DDE06_00655	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
DDE06_00675	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
DDE06_00680	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
DDE06_00695	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
DDE06_00700	ENOG4105CTQ	phosphohexokinase
DDE06_00745	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
DDE06_00755	ENOG4105CQR	helicase
DDE06_00785	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
DDE06_00790	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
DDE06_00795	ENOG4107XKF	NMT1 THI5 Like Domain Protein
DDE06_00800	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
DDE06_00805	ENOG4105DJV	ribulose-phosphate 3-epimerase
DDE06_00815	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
DDE06_00820	ENOG4107RSZ	Primosomal protein n'
DDE06_00825	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
DDE06_00835	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
DDE06_00840	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
DDE06_00850	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
DDE06_00855	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
DDE06_00860	ENOG410803B	Involved in the transcription termination process (By similarity)
DDE06_00865	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
DDE06_00870	ENOG4105C59	p-type ATPase
DDE06_00875	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
DDE06_00880	ENOG4105D49	3-dehydroquinate synthase
DDE06_00885	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
DDE06_00905	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
DDE06_00910	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
DDE06_00920	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
DDE06_00930	ENOG4107R13	MMPL domain protein
DDE06_00945	ENOG4105C9M	aspartyl-trna synthetase
DDE06_00965	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
DDE06_00970	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
DDE06_00975	ENOG4105CUT	histidyl-tRNA synthetase
DDE06_00980	ENOG4105C5X	domain protein
DDE06_00985	ENOG4105C99	atpase involved in dna repair
DDE06_00995	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
DDE06_01000	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
DDE06_01005	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
DDE06_01010	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
DDE06_01020	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
DDE06_01025	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
DDE06_01030	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
DDE06_01035	ENOG4105CDY	transcriptional regulatory protein
DDE06_01040	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
DDE06_01050	ENOG4105E2K	Glycosyl transferase (Group 1
DDE06_01065	ENOG4105C22	threonyL-tRNA synthetase
DDE06_01070	ENOG4105EJQ	L-serine dehydratase
DDE06_01075	ENOG4105WH1	Two component transcriptional regulator luxr family
DDE06_01145	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
DDE06_01155	ENOG4107QM5	aconitate hydratase
DDE06_01160	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
DDE06_01170	ENOG4107VEG	TrkA-N domain protein
DDE06_01215	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDE06_01230	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDE06_01240	ENOG4105DVT	helicase
DDE06_01245	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
DDE06_01280	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
DDE06_01285	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
DDE06_01325	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
DDE06_01340	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
DDE06_01375	ENOG4105C5F	glutamine synthetase
DDE06_01385	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
DDE06_01390	ENOG4105C5F	glutamine synthetase
DDE06_01405	ENOG4105DFK	Polyphosphate glucokinase
DDE06_01415	ENOG4105D1Q	UPF0246 protein
DDE06_01425	ENOG4105EGD	dinuclear metal center protein, YbgI family
DDE06_01430	ENOG41082CG	Protein CrcB homolog
DDE06_01435	ENOG4108680	CrcB-like protein
DDE06_01460	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
DDE06_01480	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
DDE06_01500	ENOG4105ECP	epimerase
DDE06_01505	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
DDE06_01535	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
DDE06_01540	ENOG4105EHG	Permease protein
DDE06_01575	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
DDE06_01580	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
DDE06_01590	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
DDE06_01595	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
DDE06_01615	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
DDE06_01625	ENOG4105DIK	(ABC) transporter
DDE06_01630	ENOG4105CC5	ABC transporter
DDE06_01635	ENOG41090R7	Ferric uptake
DDE06_01650	ENOG4105C0B	DNA polymerase III (alpha subunit)
DDE06_01680	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
DDE06_01690	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
DDE06_01700	ENOG4105DFU	Cell wall formation (By similarity)
DDE06_01705	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
DDE06_01710	ENOG4105CNI	cell division protein FtsW
DDE06_01715	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
DDE06_01720	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
DDE06_01730	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
DDE06_01735	ENOG4105CJN	penicillin-binding protein
DDE06_01745	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
DDE06_01750	ENOG4108V6E	Cell division protein mraZ
DDE06_01760	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
DDE06_01780	ENOG4108JQ1	Dehydrogenase
DDE06_01785	ENOG4105CEY	Amp-dependent synthetase and ligase
DDE06_01790	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
DDE06_01800	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
DDE06_01810	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
DDE06_01815	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
DDE06_01820	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
DDE06_01825	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
DDE06_01830	ENOG4105Y3E	Modulates RecA activity (By similarity)
DDE06_01835	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
DDE06_01845	ENOG4105WBV	Transcriptional regulator
DDE06_01850	ENOG4105CEV	competence damage-inducible protein
DDE06_01865	ENOG4107QZI	cell division protein FtsK
DDE06_01870	ENOG4105CN5	Metallo-Beta-Lactamase
DDE06_01885	ENOG4105C0D	helicase
DDE06_01890	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
DDE06_01895	ENOG4105C1V	Peptidase, M16
DDE06_01905	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
DDE06_01910	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
DDE06_01950	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
DDE06_01960	ENOG4105CXY	transporter
DDE06_01965	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDE06_01970	ENOG4105BZU	Histidine kinase
DDE06_01975	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
DDE06_01980	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
DDE06_01985	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
DDE06_02000	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
DDE06_02010	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
DDE06_02020	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
DDE06_02025	ENOG4105DZP	Membrane-associated zinc metalloprotease
DDE06_02030	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
DDE06_02040	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
DDE06_02050	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
DDE06_02055	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
DDE06_02075	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
DDE06_02080	ENOG4105C10	Electron transfer flavoprotein
DDE06_02090	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
DDE06_02095	ENOG4105CE9	30S ribosomal protein S2
DDE06_02100	ENOG4105EN6	Membrane
DDE06_02105	ENOG4108K5P	(LipO)protein
DDE06_02110	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DDE06_02120	ENOG4105C0P	Mg chelatase subunit ChlI
DDE06_02135	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DDE06_02140	ENOG4107QYR	Signal peptidase i
DDE06_02145	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
DDE06_02150	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
DDE06_02155	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
DDE06_02160	ENOG41082KU	UPF0109 protein
DDE06_02165	ENOG4105K5M	30s ribosomal protein S16
DDE06_02190	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
DDE06_02195	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
DDE06_02210	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
DDE06_02215	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
DDE06_02220	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
DDE06_02245	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
DDE06_02255	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
DDE06_02260	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
DDE06_02265	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
DDE06_02270	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
DDE06_02275	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
DDE06_02280	ENOG4105CPC	Aldo Keto reductase
DDE06_02290	ENOG4105D17	glycoside hydrolase, family 3 domain protein
DDE06_02295	ENOG4105CT4	transporter
DDE06_02300	ENOG4105CNT	hydrolase family 2
DDE06_02305	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_02320	ENOG4105C5H	ABC transporter
DDE06_02335	ENOG4107QN2	dihydrolipoyl dehydrogenase
DDE06_02350	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
DDE06_02360	ENOG4105D7W	serine acetyltransferase
DDE06_02375	ENOG4105C9K	Endothelin-converting enzyme 1
DDE06_02380	ENOG4105CKW	Inner membrane protein yedI
DDE06_02390	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DDE06_02435	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
DDE06_02470	ENOG4108XUD	Membrane
DDE06_02500	ENOG4105KPE	licD family
DDE06_02510	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
DDE06_02525	ENOG4105DFA	alanine racemase domain protein
DDE06_02540	ENOG4105C6N	Formate acetyltransferase
DDE06_02550	ENOG4105CM2	brancheD-chain amino acid aminotransferase
DDE06_02555	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
DDE06_02570	ENOG4108IJ0	Aspartate ammonia-lyase
DDE06_02580	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
DDE06_02585	ENOG4108ZP8	Acetolactate synthase small subunit
DDE06_02595	ENOG4105D0C	transport protein
DDE06_02600	ENOG4105C01	Dihydroxy-acid dehydratase
DDE06_02650	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
DDE06_02655	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
DDE06_02660	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
DDE06_02665	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
DDE06_02670	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
DDE06_02675	ENOG4107R3N	Filamentation induced by cAMP protein fic
DDE06_02680	ENOG4108TFM	Kinase, PfkB family
DDE06_02690	ENOG4108KD5	ADP-ribosylation crystallin J1
DDE06_02695	ENOG4105FDP	GntR family transcriptional regulator
DDE06_02700	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
DDE06_02705	ENOG4108RAV	Conserved protein
DDE06_02710	ENOG4105BZU	Histidine kinase
DDE06_02745	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
DDE06_02780	ENOG4105EWV	Sodium calcium exchanger membrane region
DDE06_02790	ENOG4105CZV	ABC transporter
DDE06_02795	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DDE06_02815	ENOG4105ESP	cell wall surface anchor family protein
DDE06_02820	ENOG4105DJZ	UPF0182 protein
DDE06_02830	ENOG41063PX	domain protein
DDE06_02860	ENOG4105C31	Tryptophanyl-tRNA synthetase
DDE06_02885	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_02895	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
DDE06_02900	ENOG4105CG3	alpha amylase, catalytic region
DDE06_02905	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
DDE06_02910	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
DDE06_02925	ENOG4105EG2	ABC transporter, permease
DDE06_02930	ENOG4105D56	permease protein
DDE06_02940	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_02945	ENOG4105CG3	alpha amylase, catalytic region
DDE06_02985	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
DDE06_02995	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
DDE06_03000	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
DDE06_03005	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
DDE06_03010	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
DDE06_03015	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
DDE06_03020	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
DDE06_03025	ENOG4105ZA1	atp synthase
DDE06_03030	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
DDE06_03050	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
DDE06_03055	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
DDE06_03060	ENOG4105VFB	Binds the 23S rRNA (By similarity)
DDE06_03070	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
DDE06_03075	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
DDE06_03080	ENOG4105D6E	homoserine dehydrogenase
DDE06_03090	ENOG4105C75	arginyL-tRNA synthetase
DDE06_03115	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_03130	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
DDE06_03135	ENOG4105DR5	peptidase
DDE06_03145	ENOG4105C37	(CBS) domain
DDE06_03150	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
DDE06_03175	ENOG4105EMN	RNA polymerase sigma factor
DDE06_03180	ENOG4105CE4	GlcNAc 6-P deacetylase
DDE06_03185	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
DDE06_03190	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
DDE06_03200	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
DDE06_03205	ENOG4108JQ7	(ABC) transporter
DDE06_03210	ENOG4105C3U	ABC transporter
DDE06_03215	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
DDE06_03255	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
DDE06_03260	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
DDE06_03265	ENOG4107TK4	histidinol-phosphate phosphatase
DDE06_03275	ENOG4105EYH	Exonuclease
DDE06_03315	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
DDE06_03325	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDE06_03335	ENOG4105D65	subunit l
DDE06_03340	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDE06_03345	ENOG41087XN	oxidoreductase
DDE06_03350	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDE06_03355	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
DDE06_03360	ENOG4108IEH	NADH dehydrogenase subunit g
DDE06_03365	ENOG4107QIZ	NADH dehydrogenase
DDE06_03375	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDE06_03380	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DDE06_03385	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
DDE06_03395	ENOG4105P52	geranylgeranyl reductase
DDE06_03400	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
DDE06_03405	ENOG4105E4F	Isochorismate synthase
DDE06_03415	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
DDE06_03420	ENOG4107TCW	O-succinylbenzoate synthase
DDE06_03425	ENOG4107SIQ	Naphthoate synthase
DDE06_03435	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
DDE06_03440	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
DDE06_03465	ENOG4108RH7	phosphoglycerate mutase
DDE06_03470	ENOG4108ZT1	Transcriptional regulator
DDE06_03485	ENOG4105CZN	Potassium uptake protein
DDE06_03490	ENOG4107ZYR	domain protein
DDE06_03495	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
DDE06_03505	ENOG4105CEN	a g-specific adenine glycosylase
DDE06_03520	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
DDE06_03525	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
DDE06_03530	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
DDE06_03535	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
DDE06_03545	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
DDE06_03550	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDE06_03555	ENOG4105EYF	MMPL domain protein
DDE06_03560	ENOG4105CRK	lysyL-tRNA synthetase
DDE06_03570	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
DDE06_03575	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
DDE06_03585	ENOG4105CMT	Dihydroxyacetone kinase
DDE06_03590	ENOG4108UTZ	Dihydroxyacetone kinase
DDE06_03595	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
DDE06_03605	ENOG4105CNT	hydrolase family 2
DDE06_03625	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_03645	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DDE06_03655	ENOG4105EUJ	GTP cyclohydrolase i
DDE06_03660	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
DDE06_03665	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
DDE06_03670	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
DDE06_03685	ENOG4105F0N	pyrophosphate phospho-hydrolase
DDE06_03690	ENOG4105K4H	Nlp p60 protein
DDE06_03695	ENOG4105DWV	Homoserine O-trans-acetylase
DDE06_03700	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
DDE06_03710	ENOG4105CQB	FAD linked oxidase domain protein
DDE06_03715	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
DDE06_03735	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
DDE06_03740	ENOG4105CG3	alpha amylase, catalytic region
DDE06_03755	ENOG4105X54	addiction module antidote protein
DDE06_03770	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
DDE06_03850	ENOG4108JJB	ABC transporter
DDE06_03855	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
DDE06_03860	ENOG4108KD5	ADP-ribosylation crystallin J1
DDE06_03880	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DDE06_03885	ENOG4105EQN	UPF0261 protein
DDE06_03895	ENOG4105KT7	mgtC SapB transporter
DDE06_03900	ENOG4105C54	Major Facilitator superfamily
DDE06_03905	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_03920	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
DDE06_03945	ENOG41089UC	methyltransferase, type 11
DDE06_03950	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_03955	ENOG4105C2J	ABC transporter
DDE06_03960	ENOG4105CNN	ABC, transporter
DDE06_03965	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
DDE06_03970	ENOG4108RVA	ribokinase
DDE06_03990	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
DDE06_03995	ENOG4105CNT	hydrolase family 2
DDE06_04000	ENOG4105E2D	ec 3.2.1.52
DDE06_04010	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
DDE06_04020	ENOG4105C6Z	Gluconate
DDE06_04025	ENOG41060NJ	transcriptional regulator
DDE06_04035	ENOG4105CNT	hydrolase family 2
DDE06_04050	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
DDE06_04055	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
DDE06_04065	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_04075	ENOG4105DRS	transport system, permease
DDE06_04095	ENOG4105DFD	Na H antiporter
DDE06_04100	ENOG4105C87	Aminotransferase class I and II
DDE06_04105	ENOG4108HWW	ABC transporter
DDE06_04115	ENOG4105DFW	ABC transporter
DDE06_04125	ENOG4105C93	Xylose Isomerase
DDE06_04140	ENOG4107QKS	N-acylglucosamine 2-epimerase
DDE06_04155	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
DDE06_04170	ENOG4105E98	transcriptional regulator DeoR family
DDE06_04180	ENOG4105CJQ	hydrolase, family 31
DDE06_04205	ENOG4105CBG	Sulfatase
DDE06_04210	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_04215	ENOG4105C54	Major Facilitator superfamily
DDE06_04220	ENOG4105C4X	radical SAM domain protein
DDE06_04225	ENOG4108VCT	Sulfite exporter TauE/SafE
DDE06_04230	ENOG4107YVI	ribose 5-phosphate isomerase
DDE06_04240	ENOG4105CMT	Dihydroxyacetone kinase
DDE06_04245	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
DDE06_04255	ENOG4105EF1	ribulokinase
DDE06_04265	ENOG4108ZYE	Transcriptional regulator
DDE06_04270	ENOG4105CMG	Carbohydrate kinase
DDE06_04275	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
DDE06_04285	ENOG4105DKT	Transcriptional regulator
DDE06_04290	ENOG4105EDR	glucose galactose transporter
DDE06_04300	ENOG4108RVA	ribokinase
DDE06_04305	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DDE06_04310	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
DDE06_04320	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
DDE06_04325	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
DDE06_04335	ENOG4105CGH	5'-nucleotidase
DDE06_04355	ENOG4105CJ3	phosphate transporter
DDE06_04360	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
DDE06_04375	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
DDE06_04385	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
DDE06_04445	ENOG4105C2M	dna polymerase I
DDE06_04500	ENOG4107RHI	Cytosine-specific methyltransferase
DDE06_04525	ENOG4105CAR	Terminase, large subunit
DDE06_04535	ENOG4105EFC	phage portal protein HK97 family
DDE06_04570	ENOG4106H3A	restriction
DDE06_04670	ENOG4105XSJ	toxin secretion phage lysis holin
DDE06_04730	ENOG4105E0X	reductase
DDE06_04755	ENOG4105CJR	Integral membrane protein (MviN
DDE06_04760	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DDE06_04775	ENOG4108YG4	
DDE06_04790	ENOG4105C94	Transporter
DDE06_04820	ENOG4105D82	Glutamate dehydrogenase
DDE06_04825	ENOG4105C8V	SAICAR synthetase
DDE06_04830	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
DDE06_04835	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
DDE06_04845	ENOG4107RCW	fructose-bisphosphate aldolase
DDE06_04860	ENOG4105M6F	mutator MutT protein
DDE06_04895	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
DDE06_04905	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
DDE06_04915	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
DDE06_04925	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
DDE06_04950	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DDE06_04955	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DDE06_04960	ENOG4105CFG	Acts as a chaperone (By similarity)
DDE06_04970	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
DDE06_04975	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
DDE06_04980	ENOG4105CXT	aspartate transcarbamylase
DDE06_04985	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
DDE06_04995	ENOG4107QY8	reductase
DDE06_05000	ENOG4105QAX	Iron-sulfur
DDE06_05010	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
DDE06_05020	ENOG4107QY8	reductase
DDE06_05025	ENOG4105QAX	Iron-sulfur
DDE06_05045	ENOG4105C4B	ABC transporter, permease
DDE06_05050	ENOG4105DKQ	ROK family
DDE06_05075	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
DDE06_05095	ENOG4108UCS	ABC, transporter
DDE06_05100	ENOG4105E0C	molybdate abc transporter
DDE06_05105	ENOG4105DP9	ABC transporter
DDE06_05130	ENOG4108JPZ	Monovalent cation H antiporter subunit D
DDE06_05135	ENOG4105MKQ	Monovalent cation H antiporter subunit C
DDE06_05140	ENOG4105D65	subunit l
DDE06_05145	ENOG4105DHP	deoxycytidine triphosphate deaminase
DDE06_05190	ENOG4105CMM	transposase
DDE06_05220	ENOG4105C6E	dna polymerase iii
DDE06_05225	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
DDE06_05230	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
DDE06_05235	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
DDE06_05245	ENOG4105VMP	Transcriptional regulator
DDE06_05295	ENOG4105D74	hydrolase
DDE06_05325	ENOG4105BZ4	penicillin-binding protein
DDE06_05340	ENOG4108IUK	alpha amylase, catalytic
DDE06_05350	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
DDE06_05360	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
DDE06_05370	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
DDE06_05420	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
DDE06_05425	ENOG4105DPH	UPF0371 protein
DDE06_05430	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
DDE06_05440	ENOG4108Z6B	deaminase
DDE06_05445	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
DDE06_05470	ENOG4105CQC	Prephenate dehydratase
DDE06_05480	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
DDE06_05485	ENOG4108KP7	hydrolase
DDE06_05515	ENOG4108RVA	ribokinase
DDE06_05520	ENOG4105D4B	ABC, transporter
DDE06_05525	ENOG4105CNN	ABC, transporter
DDE06_05555	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
DDE06_05645	ENOG41082EK	Restriction modification system DNA (Specificity
DDE06_05675	ENOG4105NUN	Orthopoxvirus protein of unknown function (DUF830)
DDE06_05685	ENOG4105I1K	ABC transporter
DDE06_05690	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
DDE06_05705	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_05710	ENOG4108JJ8	(ABC) transporter
DDE06_05715	ENOG4105BZ1	(ABC) transporter
DDE06_05730	ENOG4105DQ5	transport system permease protein
DDE06_05740	ENOG4105E0A	ABC, transporter
DDE06_05750	ENOG4105DXX	methyltransferase
DDE06_05755	ENOG4105D7K	pfkb domain protein
DDE06_05760	ENOG4108UHU	Aldolase
DDE06_05765	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
DDE06_05770	ENOG4105DEI	Mannitol dehydrogenase
DDE06_05775	ENOG4108FUF	Transcriptional regulator, IclR family
DDE06_05780	ENOG4105D5T	phosphonate abc transporter
DDE06_05795	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
DDE06_05800	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
DDE06_05805	ENOG4105DSB	aldose 1-epimerase
DDE06_05810	ENOG4105WH1	Two component transcriptional regulator luxr family
DDE06_05820	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_05830	ENOG4108M15	ABC transporter
DDE06_05840	ENOG4108ZGX	Histidine kinase
DDE06_05845	ENOG4108S01	response regulator
DDE06_05850	ENOG4105CQ7	ATP-dependent helicase
DDE06_05860	ENOG4105H3G	oxidoreductase
DDE06_05880	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
DDE06_05885	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
DDE06_05900	ENOG4107ZF2	Phosphatase
DDE06_05905	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
DDE06_05915	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
DDE06_05920	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
DDE06_05925	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
DDE06_05940	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
DDE06_05945	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
DDE06_05955	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
DDE06_05975	ENOG4105IDI	abc transporter atp-binding protein
DDE06_06000	ENOG4105D9P	serine threonine protein kinase
DDE06_06005	ENOG4108RN7	integral membrane protein
DDE06_06010	ENOG4105ZJT	Cell division protein CrgA
DDE06_06055	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDE06_06060	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
DDE06_06070	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
DDE06_06075	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
DDE06_06080	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
DDE06_06095	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
DDE06_06100	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
DDE06_06110	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
DDE06_06115	ENOG4107QJE	Chromosome Partitioning Protein
DDE06_06125	ENOG4105CPF	Cell wall formation (By similarity)
DDE06_06130	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DDE06_06135	ENOG4105C3M	thioredoxin reductase
DDE06_06155	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
DDE06_06165	ENOG4105DSF	transport protein
DDE06_06170	ENOG4105BZ4	penicillin-binding protein
DDE06_06175	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
DDE06_06180	ENOG4107YH6	single-stranded DNA-binding protein
DDE06_06185	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
DDE06_06190	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
DDE06_06195	ENOG4105CGH	5'-nucleotidase
DDE06_06210	ENOG4105CDU	Replicative dna helicase
DDE06_06215	ENOG4107Y80	Major Facilitator superfamily
DDE06_06225	ENOG4105CUZ	uba thif-type nad fad binding protein
DDE06_06240	ENOG4105DWF	phosphomethylpyrimidine kinase
DDE06_06245	ENOG4105CV8	reductase
DDE06_06285	ENOG4105ZMH	deoxynucleoside kinase
DDE06_06295	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
DDE06_06300	ENOG4106F60	Histidine kinase
DDE06_06305	ENOG4105F44	Two component transcriptional regulator, winged helix family
DDE06_06320	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
DDE06_06325	ENOG4107RBB	ABC transporter, permease
DDE06_06355	ENOG4105CZN	Potassium uptake protein
DDE06_06370	ENOG4105CQ7	ATP-dependent helicase
DDE06_06415	ENOG4108UVJ	appr-1-p processing domain protein
DDE06_06420	ENOG4105CEP	NADH dehydrogenase
DDE06_06450	ENOG41061GT	Aldolase
DDE06_06460	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
DDE06_06470	ENOG4105D4B	ABC, transporter
DDE06_06480	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
DDE06_06485	ENOG4105C2J	ABC transporter
DDE06_06515	ENOG4105C8P	)-transporter
DDE06_06530	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
DDE06_06535	ENOG4108JJB	ABC transporter
DDE06_06595	ENOG4105E2R	ROK family
DDE06_06600	ENOG4105DKQ	ROK family
DDE06_06610	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
DDE06_06625	ENOG4108NZE	NAGC-like transcriptional regulator
DDE06_06640	ENOG4106N3A	copper homeostasis protein cutc
DDE06_06655	ENOG4105D2H	Uronic isomerase
DDE06_06660	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
DDE06_06665	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
DDE06_06670	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
DDE06_06675	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
DDE06_06680	ENOG4108MES	Periplasmic binding protein
DDE06_06685	ENOG4105DHS	permease protein
DDE06_06690	ENOG4105CM4	permease protein
DDE06_06695	ENOG4108IPW	abc transporter atp-binding protein
DDE06_06700	ENOG4105C26	Dehydrogenase
DDE06_06705	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
DDE06_06710	ENOG4105DH8	myo-inositol catabolism
DDE06_06730	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
DDE06_06745	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
DDE06_06755	ENOG4105CNN	ABC, transporter
DDE06_06760	ENOG4105D4B	ABC, transporter
DDE06_06765	ENOG4105ECY	inositol monophosphatase
DDE06_06770	ENOG4105CXY	transporter
DDE06_06775	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_06780	ENOG4105CPQ	Dehydrogenase
DDE06_06800	ENOG4108JJB	ABC transporter
DDE06_06805	ENOG4105BZ1	(ABC) transporter
DDE06_06850	ENOG4107T5V	SNARE associated Golgi
DDE06_06855	ENOG4107QTF	adenylosuccinate lyase
DDE06_06860	ENOG41082T9	Membrane
DDE06_06865	ENOG4105CIH	Imidazole acetol-phosphate transaminase
DDE06_06880	ENOG4105FF2	Type I DHQase
DDE06_06890	ENOG4105CPC	Aldo Keto reductase
DDE06_06895	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
DDE06_06900	ENOG4105VE1	Phosphatidylcholine synthase
DDE06_06915	ENOG4107RES	phosphoglycerol transferase I
DDE06_06925	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
DDE06_06930	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
DDE06_06940	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
DDE06_06960	ENOG4105EHG	Permease protein
DDE06_06965	ENOG4105E0A	ABC, transporter
DDE06_07010	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
DDE06_07025	ENOG4105BZU	Histidine kinase
DDE06_07040	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
DDE06_07045	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
DDE06_07065	ENOG4105DT3	PTS system, galactitol-specific IIc component
DDE06_07070	ENOG4107W7X	Aldolase
DDE06_07080	ENOG4105CMT	Dihydroxyacetone kinase
DDE06_07105	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_07115	ENOG4105C8N	cysteinyl-tRNA synthetase
DDE06_07135	ENOG4105C2W	permease
DDE06_07160	ENOG4105D22	carbon starvation protein
DDE06_07175	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
DDE06_07180	ENOG4105CFH	Aspartokinase
DDE06_07205	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
DDE06_07210	ENOG4108JE9	extracellular solute-binding protein family 1
DDE06_07220	ENOG4105CK5	oxidoreductase
DDE06_07230	ENOG4108IJ9	(ABC) transporter
DDE06_07280	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
DDE06_07295	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
DDE06_07310	ENOG4105PDP	Short chain dehydrogenase
DDE06_07320	ENOG4105BZU	Histidine kinase
DDE06_07325	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDE06_07345	ENOG4105VEQ	Cold shock protein
DDE06_07355	ENOG4105EIP	mannose-6-phosphate isomerase
DDE06_07360	ENOG4105C7N	Xanthine uracil vitamin C permease
DDE06_07365	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
DDE06_07445	ENOG4105YES	addiction module antidote protein
DDE06_07450	ENOG4105VUH	addiction module killer protein
DDE06_07465	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
DDE06_07480	ENOG4108HUF	Transporter
DDE06_07485	ENOG4108U1V	ABC transporter, permease
DDE06_07490	ENOG4108U1V	ABC transporter, permease
DDE06_07495	ENOG4105E0A	ABC, transporter
DDE06_07500	ENOG4105FDP	GntR family transcriptional regulator
DDE06_07525	ENOG4105KDC	50s ribosomal protein l28
DDE06_07530	ENOG4105W0E	50S ribosomal protein L33
DDE06_07535	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
DDE06_07540	ENOG4105NRA	50s ribosomal protein l31 type b
DDE06_07545	ENOG4108638	50S ribosomal protein L36
DDE06_07560	ENOG4105VUC	UPF0237 protein
DDE06_07565	ENOG4105CAG	UPF0210 protein
DDE06_07575	ENOG4105ECB	domain protein
DDE06_07590	ENOG4105CID	antiterminator
DDE06_07600	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
DDE06_07635	ENOG4105C5Y	PTS System
DDE06_07640	ENOG41082BZ	phosphocarrier protein (HPr)
DDE06_07660	ENOG41080R8	Conserved Protein
DDE06_07665	ENOG4107QR9	Iron-sulfur cluster binding protein
DDE06_07670	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
DDE06_07675	ENOG4105DAA	L-lactate
DDE06_07680	ENOG4105CRK	lysyL-tRNA synthetase
DDE06_07700	ENOG4105C94	Transporter
DDE06_07705	ENOG4107RNR	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity)
DDE06_07720	ENOG4105DA5	(ABC) transporter
DDE06_07760	ENOG4108RWI	nicotinamidase
DDE06_07795	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
DDE06_07800	ENOG4105F8V	Hydrolase, tatD family
DDE06_07810	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
DDE06_07815	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
DDE06_07820	ENOG4105C5H	ABC transporter
DDE06_07830	ENOG4105RHA	ABC transporter, permease
DDE06_07835	ENOG4108IUX	(ABC) transporter
DDE06_07850	ENOG4108IG5	Transcriptional regulator
DDE06_07860	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
DDE06_07865	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
DDE06_07875	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
DDE06_07890	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
DDE06_07935	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
DDE06_07940	ENOG4105CZV	ABC transporter
DDE06_07955	ENOG4105C26	Dehydrogenase
DDE06_07960	ENOG4105CK7	Sodium proline symporter
DDE06_07975	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
DDE06_07980	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
DDE06_07985	ENOG4105T1M	mycothiol conjugate amidase mca
DDE06_07995	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
DDE06_08000	ENOG4105D7K	pfkb domain protein
DDE06_08005	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
DDE06_08015	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
DDE06_08030	ENOG4108IUW	ABC transporter
DDE06_08045	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
DDE06_08050	ENOG4105CGY	Dna recombination protein
DDE06_08055	ENOG4105C3G	gtp-binding protein
DDE06_08085	ENOG4105CSH	Transporter
DDE06_08090	ENOG4105CH2	amidohydrolase
DDE06_08100	ENOG4105CG3	alpha amylase, catalytic region
DDE06_08105	ENOG4105BZ7	extracellular solute-binding protein family 1
DDE06_08115	ENOG4105DRS	transport system, permease
DDE06_08130	ENOG4105CEU	Arginine dihydrolase
DDE06_08135	ENOG4105DBV	ornithine carbamoyltransferase
DDE06_08155	ENOG4105CSH	Transporter
DDE06_08160	ENOG4108RFG	Tetr family transcriptional regulator
DDE06_08165	ENOG4108YYH	Nadph-dependent fmn reductase
DDE06_08175	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
DDE06_08200	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
DDE06_08205	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
DDE06_08215	ENOG4105TMB	Formate nitrite transporter
DDE06_08230	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
DDE06_08240	ENOG4108JQ7	(ABC) transporter
DDE06_08270	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
DDE06_08295	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_08300	ENOG4105E2R	ROK family
DDE06_08305	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
DDE06_08310	ENOG4105DRS	transport system, permease
DDE06_08320	ENOG4105CJQ	hydrolase, family 31
DDE06_08325	ENOG4105CG3	alpha amylase, catalytic region
DDE06_08335	ENOG4105CUC	YeeE YedE family protein
DDE06_08340	ENOG4105E9K	Isocitrate dehydrogenase
DDE06_08355	ENOG4105DFM	M18 family aminopeptidase
DDE06_08365	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
DDE06_08370	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
DDE06_08400	ENOG4105BZ1	(ABC) transporter
DDE06_08410	ENOG4105CI3	gtp-binding protein typa
DDE06_08425	ENOG4108Z4U	Ferredoxin
DDE06_08445	ENOG4107WR6	Maf-like protein
DDE06_08460	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDE06_08475	ENOG4108KGH	TRANSCRIPTIONal
DDE06_08480	ENOG4108KGH	TRANSCRIPTIONal
DDE06_08485	ENOG4107RGC	Glycosyl transferase, family 2
DDE06_08495	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
DDE06_08555	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
DDE06_08580	ENOG4105EY8	ABC transporter
DDE06_08590	ENOG4107RGC	Glycosyl transferase, family 2
DDE06_08615	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
DDE06_08620	ENOG4105C09	Bile acid
DDE06_08635	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
DDE06_08640	ENOG4107RGC	Glycosyl transferase, family 2
DDE06_08675	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
DDE06_08695	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
DDE06_08700	ENOG4105BZU	Histidine kinase
DDE06_08705	ENOG4108T3R	lipoprotein lpqB
DDE06_08710	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
DDE06_08715	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
DDE06_08725	ENOG4108VPT	UPF0234 protein
DDE06_08745	ENOG4105WDJ	50S ribosomal protein L33
DDE06_08760	ENOG4107R4N	Cell wall formation (By similarity)
DDE06_08775	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
DDE06_08800	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
DDE06_08805	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
DDE06_08810	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
DDE06_08820	ENOG4108VZM	50s ribosomal protein L10
DDE06_08825	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
DDE06_08830	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDE06_08835	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDE06_08840	ENOG4108IQI	permease
DDE06_08845	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
DDE06_08850	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
DDE06_08855	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
DDE06_08860	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
DDE06_08870	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
DDE06_08875	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
DDE06_08880	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
DDE06_08885	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
DDE06_08890	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
DDE06_08895	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DDE06_08900	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
DDE06_08905	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
DDE06_08910	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
DDE06_08915	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
DDE06_08925	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
DDE06_08930	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
DDE06_08935	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
DDE06_08940	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DDE06_08945	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
DDE06_08950	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
DDE06_08955	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
DDE06_08965	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
DDE06_08970	ENOG4105VPB	50S ribosomal protein L30
DDE06_08975	ENOG4107ZG5	Binds to the 23S rRNA (By similarity)
DDE06_08985	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
DDE06_08995	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
DDE06_09000	ENOG41067V7	50S ribosomal protein L36
DDE06_09005	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DDE06_09015	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
DDE06_09020	ENOG4108ZT0	50S ribosomal protein l17
DDE06_09025	ENOG4108VPT	UPF0234 protein
DDE06_09035	ENOG4107TXC	Transcriptional regulator
DDE06_09040	ENOG4108JEH	abc transporter atp-binding protein
DDE06_09045	ENOG4105E5Q	amino acid AbC transporter
DDE06_09055	ENOG4105DFK	Polyphosphate glucokinase
DDE06_09060	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
DDE06_09070	ENOG4105JQN	Transcriptional regulator
DDE06_09080	ENOG4108JJB	ABC transporter
DDE06_09085	ENOG4108V7D	UPF0397 protein
DDE06_09095	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
DDE06_09100	ENOG4108UJD	30S ribosomal protein S9
DDE06_09110	ENOG4105CS9	pantothenic acid kinase
DDE06_09115	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
DDE06_09125	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
DDE06_09130	ENOG4108097	ATP-binding protein
DDE06_09160	ENOG4105E33	succinate dehydrogenase
DDE06_09170	ENOG4105C8J	)-transporter
DDE06_09175	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
DDE06_09180	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
DDE06_09195	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
DDE06_09205	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
DDE06_09210	ENOG4105C8V	SAICAR synthetase
DDE06_09215	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
DDE06_09220	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
DDE06_09225	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
DDE06_09230	ENOG4105C12	Phosphoribosylglycinamide synthetase
DDE06_09235	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
DDE06_09250	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
DDE06_09260	ENOG4107QVP	Dehydrogenase
DDE06_09265	ENOG4105C9Q	fumarate hydratase class II
DDE06_09275	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
DDE06_09290	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
DDE06_09295	ENOG4105C6K	Malic enzyme
DDE06_09300	ENOG4105DR9	pseudouridine synthase
DDE06_09305	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
DDE06_09320	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
DDE06_09355	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
DDE06_09385	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
DDE06_09430	ENOG4105K4H	Nlp p60 protein
DDE06_09490	ENOG4105DF9	Lipoate-protein, ligase
DDE06_09545	ENOG4105EXC	Acyl-transferase
DDE06_09550	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
DDE06_09580	ENOG4105CTQ	phosphohexokinase
DDE06_09585	ENOG4107QP8	phosphohexose isomerase
DDE06_09630	ENOG4105F9F	transposase
DDE06_09635	ENOG4105F9F	transposase
DDE06_09650	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
DDE06_09685	ENOG4105CEY	Amp-dependent synthetase and ligase
DDE06_09695	ENOG4105C54	Major Facilitator superfamily
DDE06_09700	ENOG4105C5X	domain protein
DDE06_09715	ENOG4105C10	Electron transfer flavoprotein
DDE06_09720	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
DDE06_09740	ENOG4108JIK	carboxylase
DDE06_09745	ENOG4105D8K	carboxyl transferase
DDE06_09750	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
DDE06_09760	ENOG4107ZYJ	bioY protein
DDE06_09770	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
DDE06_09775	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
DDE06_09790	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
DDE06_09795	ENOG4105DIH	basic membrane
DDE06_09800	ENOG4108JQ9	ABC transporter
DDE06_09805	ENOG4105UIB	(ABC) transporter
DDE06_09830	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
DDE06_09835	ENOG4105E5M	Multidrug resistance protein D
DDE06_09840	ENOG4105KBX	Transcriptional regulator, TetR family
DDE06_09845	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
DDE06_09855	ENOG4108URH	decarboxylase
DDE06_09880	ENOG4105CJW	magnesium transporter
DDE06_09885	ENOG4107T6F	Xaa-Pro aminopeptidase
DDE06_09895	ENOG41081FY	multiple antibiotic resistance (MarC)-related
DDE06_09900	ENOG4105C1J	atp-dependent rna helicase
DDE06_09960	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
DDE06_09965	ENOG4105CAK	Cell division ATP-binding protein ftsE
DDE06_09970	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
DDE06_09975	ENOG4105DR5	peptidase
DDE06_09980	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
DDE06_10015	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
DDE06_10020	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
DDE06_10025	ENOG4105GVJ	transcriptional regulator
DDE06_10040	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
DDE06_10065	ENOG4105C4K	Nad synthetase
DDE06_10080	ENOG4107WGA	YidE YbjL
DDE06_10085	ENOG4108426	dNA-binding protein
DDE06_10105	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
DDE06_10115	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
DDE06_10125	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
DDE06_10130	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
DDE06_10155	ENOG4108IQE	Amp-dependent synthetase and ligase
DDE06_10160	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
DDE06_10165	ENOG4105C87	Aminotransferase class I and II
DDE06_10170	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
DDE06_10180	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_10215	ENOG4105DGW	oligopeptidase A
DDE06_10225	ENOG4105CSC	Glucose uptake protein
DDE06_10235	ENOG4105JNK	Glycosyl transferase (Group 1
DDE06_10245	ENOG4105DZW	Dipeptidase
DDE06_10255	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
DDE06_10260	ENOG4105CPF	Cell wall formation (By similarity)
DDE06_10270	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
DDE06_10280	ENOG4105VB9	50S ribosomal protein l28
DDE06_10295	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
DDE06_10310	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
DDE06_10315	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
DDE06_10325	ENOG4108JU3	Alkyl hydroperoxide reductase
DDE06_10330	ENOG4105D3R	alkyl hydroperoxide reductase
DDE06_10335	ENOG4105BZ1	(ABC) transporter
DDE06_10340	ENOG4105BZ1	(ABC) transporter
DDE06_10350	ENOG4108JJ8	(ABC) transporter
DDE06_10355	ENOG4108JJ9	ABC, transporter
DDE06_10360	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
DDE06_10365	ENOG4105C4M	(Ubiquinol oxidase) subunit I
DDE06_10375	ENOG4105C03	ribonuclease
DDE06_10380	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
DDE06_10385	ENOG4105K46	50S ribosomal protein l27
DDE06_10390	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DDE06_10400	ENOG41080RH	Thioredoxin
DDE06_10405	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
DDE06_10415	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
DDE06_10420	ENOG4105CVJ	phosphoglycerate mutase
DDE06_10455	ENOG4105FB2	class II Aldolase
DDE06_10460	ENOG4105EDR	glucose galactose transporter
DDE06_10465	ENOG4105NWF	RbsD or FucU transport
DDE06_10470	ENOG4105ETE	Transcriptional regulator (LacI family
DDE06_10475	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
DDE06_10480	ENOG4107VMI	polysaccharide deacetylase
DDE06_10525	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
DDE06_10540	ENOG4105CFP	Peptidase U32
DDE06_10545	ENOG4108UMN	azlc family
DDE06_10555	ENOG4105C85	amino acid
DDE06_10560	ENOG4105D01	(LipO)protein
DDE06_10565	ENOG4108UMI	ABC transporter, permease
DDE06_10575	ENOG4107GFK	fumarate
DDE06_10580	ENOG4105C85	amino acid
DDE06_10590	ENOG41067QW	Transcriptional regulator
DDE06_10600	ENOG410841Q	phosphoesterase PA-phosphatase related protein
DDE06_10615	ENOG4105CC5	ABC transporter
DDE06_10630	ENOG4107SIG	periplasmic solute binding protein
DDE06_10650	ENOG4107104	thymidine kinase
DDE06_10655	ENOG4107RPQ	ABC transporter
DDE06_10660	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
DDE06_10685	ENOG4105C8T	Leucyl-tRNA synthetase
DDE06_10700	ENOG4105D7A	ATP-binding protein
DDE06_10720	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
DDE06_10725	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
DDE06_10730	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
DDE06_10755	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
DDE06_10760	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
DDE06_10780	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
DDE06_10785	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
DDE06_10790	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)