locus-tag	class	description
EB776_00105	ENOG4105WXW	Antirepressor
EB776_00170	ENOG4105CEC	DNA methylase N-4 N-6
EB776_00180	ENOG4105D85	methylase
EB776_00185	ENOG4105F6A	helicase
EB776_00190	ENOG4105ECI	YeeC-like protein
EB776_00245	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
EB776_00260	ENOG4105X54	addiction module antidote protein
EB776_00275	ENOG4105CG3	alpha amylase, catalytic region
EB776_00280	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
EB776_00300	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
EB776_00305	ENOG4105CQB	FAD linked oxidase domain protein
EB776_00315	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
EB776_00320	ENOG4105DWV	Homoserine O-trans-acetylase
EB776_00325	ENOG4105K4H	Nlp p60 protein
EB776_00330	ENOG4105F0N	pyrophosphate phospho-hydrolase
EB776_00345	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
EB776_00350	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
EB776_00355	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EB776_00360	ENOG4105EUJ	GTP cyclohydrolase i
EB776_00370	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EB776_00390	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_00410	ENOG4105CNT	hydrolase family 2
EB776_00420	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
EB776_00425	ENOG4108UTZ	Dihydroxyacetone kinase
EB776_00430	ENOG4105CMT	Dihydroxyacetone kinase
EB776_00440	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
EB776_00445	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
EB776_00455	ENOG4105CRK	lysyL-tRNA synthetase
EB776_00460	ENOG4105EYF	MMPL domain protein
EB776_00465	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EB776_00470	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
EB776_00480	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
EB776_00485	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EB776_00490	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
EB776_00495	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
EB776_00510	ENOG4105CEN	a g-specific adenine glycosylase
EB776_00520	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
EB776_00525	ENOG4107ZYR	domain protein
EB776_00530	ENOG4105CZN	Potassium uptake protein
EB776_00545	ENOG4108ZT1	Transcriptional regulator
EB776_00550	ENOG4108RH7	phosphoglycerate mutase
EB776_00575	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
EB776_00580	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
EB776_00590	ENOG4107SIQ	Naphthoate synthase
EB776_00595	ENOG4107TCW	O-succinylbenzoate synthase
EB776_00600	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
EB776_00605	ENOG4105C0H	protease
EB776_00610	ENOG4105E4F	Isochorismate synthase
EB776_00615	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EB776_00620	ENOG4105P52	geranylgeranyl reductase
EB776_00630	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EB776_00635	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EB776_00640	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EB776_00650	ENOG4107QIZ	NADH dehydrogenase
EB776_00655	ENOG4108IEH	NADH dehydrogenase subunit g
EB776_00660	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
EB776_00665	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EB776_00670	ENOG41087XN	oxidoreductase
EB776_00675	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EB776_00680	ENOG4105D65	subunit l
EB776_00690	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EB776_00700	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EB776_00740	ENOG4105EYH	Exonuclease
EB776_00750	ENOG4107TK4	histidinol-phosphate phosphatase
EB776_00755	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
EB776_00760	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EB776_00795	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
EB776_00800	ENOG4105C3U	ABC transporter
EB776_00805	ENOG4108JQ7	(ABC) transporter
EB776_00810	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EB776_00820	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
EB776_00825	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
EB776_00830	ENOG4105CE4	GlcNAc 6-P deacetylase
EB776_00835	ENOG4105EMN	RNA polymerase sigma factor
EB776_00855	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
EB776_00885	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
EB776_00890	ENOG4105C37	(CBS) domain
EB776_00900	ENOG4105DR5	peptidase
EB776_00905	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
EB776_00920	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_00945	ENOG4105C75	arginyL-tRNA synthetase
EB776_00955	ENOG4105D6E	homoserine dehydrogenase
EB776_00960	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
EB776_00965	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
EB776_00975	ENOG4105VFB	Binds the 23S rRNA (By similarity)
EB776_00980	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
EB776_00985	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EB776_01005	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
EB776_01010	ENOG4105ZA1	atp synthase
EB776_01015	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
EB776_01020	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EB776_01025	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EB776_01030	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EB776_01035	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EB776_01040	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EB776_01050	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
EB776_01090	ENOG4105CG3	alpha amylase, catalytic region
EB776_01095	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_01105	ENOG4105D56	permease protein
EB776_01110	ENOG4105EG2	ABC transporter, permease
EB776_01120	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
EB776_01125	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
EB776_01130	ENOG4105CG3	alpha amylase, catalytic region
EB776_01135	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
EB776_01145	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_01170	ENOG4105C31	Tryptophanyl-tRNA synthetase
EB776_01200	ENOG41063PX	domain protein
EB776_01210	ENOG4105DJZ	UPF0182 protein
EB776_01215	ENOG4105ESP	cell wall surface anchor family protein
EB776_01235	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EB776_01240	ENOG4105CZV	ABC transporter
EB776_01250	ENOG4105EWV	Sodium calcium exchanger membrane region
EB776_01285	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
EB776_01320	ENOG4105BZU	Histidine kinase
EB776_01325	ENOG4108RAV	Conserved protein
EB776_01330	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EB776_01335	ENOG4105FDP	GntR family transcriptional regulator
EB776_01340	ENOG4108KD5	ADP-ribosylation crystallin J1
EB776_01350	ENOG4108TFM	Kinase, PfkB family
EB776_01355	ENOG4107R3N	Filamentation induced by cAMP protein fic
EB776_01360	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
EB776_01365	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EB776_01370	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EB776_01375	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EB776_01380	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EB776_01435	ENOG4105C01	Dihydroxy-acid dehydratase
EB776_01440	ENOG4105D0C	transport protein
EB776_01450	ENOG4108ZP8	Acetolactate synthase small subunit
EB776_01455	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
EB776_01475	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EB776_01480	ENOG4105C6N	Formate acetyltransferase
EB776_01495	ENOG4105DFA	alanine racemase domain protein
EB776_01510	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EB776_01520	ENOG4105KPE	licD family
EB776_01550	ENOG4108XUD	Membrane
EB776_01585	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
EB776_01615	ENOG4105C29	acyl-CoA thioesterase
EB776_01630	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EB776_01640	ENOG4105CKW	Inner membrane protein yedI
EB776_01645	ENOG4105C9K	Endothelin-converting enzyme 1
EB776_01655	ENOG4105D7W	serine acetyltransferase
EB776_01665	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EB776_01680	ENOG4107QN2	dihydrolipoyl dehydrogenase
EB776_01730	ENOG4105C5H	ABC transporter
EB776_01745	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_01750	ENOG4105CNT	hydrolase family 2
EB776_01755	ENOG4105CT4	transporter
EB776_01760	ENOG4105D17	glycoside hydrolase, family 3 domain protein
EB776_01770	ENOG4105CPC	Aldo Keto reductase
EB776_01775	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
EB776_01780	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EB776_01785	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EB776_01790	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EB776_01795	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
EB776_01805	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EB776_01830	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
EB776_01835	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EB776_01840	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
EB776_01855	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
EB776_01860	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
EB776_01885	ENOG4105K5M	30s ribosomal protein S16
EB776_01890	ENOG41082KU	UPF0109 protein
EB776_01895	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
EB776_01900	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EB776_01905	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EB776_01910	ENOG4107QYR	Signal peptidase i
EB776_01915	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EB776_01930	ENOG4105C0P	Mg chelatase subunit ChlI
EB776_01940	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EB776_01945	ENOG4108K5P	(LipO)protein
EB776_01950	ENOG4105EN6	Membrane
EB776_01955	ENOG4105CE9	30S ribosomal protein S2
EB776_01960	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EB776_01970	ENOG4105C10	Electron transfer flavoprotein
EB776_01975	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
EB776_01995	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EB776_02000	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
EB776_02010	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
EB776_02020	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
EB776_02025	ENOG4105DZP	Membrane-associated zinc metalloprotease
EB776_02030	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
EB776_02040	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EB776_02050	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
EB776_02065	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EB776_02070	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EB776_02075	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EB776_02080	ENOG4105BZU	Histidine kinase
EB776_02085	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EB776_02090	ENOG4105CXY	transporter
EB776_02100	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EB776_02130	ENOG4105CJ1	ABC, transporter
EB776_02140	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EB776_02145	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
EB776_02155	ENOG4105C1V	Peptidase, M16
EB776_02160	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
EB776_02165	ENOG4105C0D	helicase
EB776_02180	ENOG4105CN5	Metallo-Beta-Lactamase
EB776_02185	ENOG4107QZI	cell division protein FtsK
EB776_02200	ENOG4105CEV	competence damage-inducible protein
EB776_02205	ENOG4105WBV	Transcriptional regulator
EB776_02215	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EB776_02220	ENOG4105Y3E	Modulates RecA activity (By similarity)
EB776_02225	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EB776_02230	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
EB776_02235	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
EB776_02240	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
EB776_02250	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EB776_02260	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
EB776_02265	ENOG4105CEY	Amp-dependent synthetase and ligase
EB776_02270	ENOG4108JQ1	Dehydrogenase
EB776_02290	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EB776_02300	ENOG4108V6E	Cell division protein mraZ
EB776_02305	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EB776_02315	ENOG4105CJN	penicillin-binding protein
EB776_02320	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EB776_02330	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EB776_02335	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
EB776_02345	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
EB776_02350	ENOG4105DFU	Cell wall formation (By similarity)
EB776_02360	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EB776_02370	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
EB776_02400	ENOG4105C0B	DNA polymerase III (alpha subunit)
EB776_02415	ENOG41090R7	Ferric uptake
EB776_02420	ENOG4105CC5	ABC transporter
EB776_02425	ENOG4105DIK	(ABC) transporter
EB776_02435	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
EB776_02455	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
EB776_02460	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
EB776_02470	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
EB776_02475	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
EB776_02510	ENOG4105EHG	Permease protein
EB776_02515	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
EB776_02545	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EB776_02550	ENOG4105ECP	epimerase
EB776_02570	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
EB776_02590	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EB776_02615	ENOG4108680	CrcB-like protein
EB776_02620	ENOG41082CG	Protein CrcB homolog
EB776_02625	ENOG4105EGD	dinuclear metal center protein, YbgI family
EB776_02635	ENOG4105D1Q	UPF0246 protein
EB776_02645	ENOG4105DFK	Polyphosphate glucokinase
EB776_02660	ENOG4105C5F	glutamine synthetase
EB776_02665	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
EB776_02675	ENOG4105C5F	glutamine synthetase
EB776_02710	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EB776_02725	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EB776_02765	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
EB776_02770	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
EB776_02805	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EB776_02810	ENOG4105DVT	helicase
EB776_02820	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EB776_02835	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EB776_02880	ENOG4107VEG	TrkA-N domain protein
EB776_02890	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EB776_02895	ENOG4107QM5	aconitate hydratase
EB776_02905	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
EB776_02970	ENOG4105WH1	Two component transcriptional regulator luxr family
EB776_02975	ENOG4105EJQ	L-serine dehydratase
EB776_02980	ENOG4105C22	threonyL-tRNA synthetase
EB776_02995	ENOG4105E2K	Glycosyl transferase (Group 1
EB776_03005	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
EB776_03010	ENOG4105CDY	transcriptional regulatory protein
EB776_03015	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
EB776_03020	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EB776_03025	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
EB776_03035	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EB776_03040	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EB776_03045	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EB776_03050	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EB776_03060	ENOG4105C99	atpase involved in dna repair
EB776_03065	ENOG4105C5X	domain protein
EB776_03070	ENOG4105CUT	histidyl-tRNA synthetase
EB776_03075	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EB776_03080	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EB776_03100	ENOG4105C9M	aspartyl-trna synthetase
EB776_03115	ENOG4107R13	MMPL domain protein
EB776_03125	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EB776_03135	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EB776_03140	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EB776_03160	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EB776_03165	ENOG4105D49	3-dehydroquinate synthase
EB776_03170	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EB776_03175	ENOG4105C59	p-type ATPase
EB776_03180	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EB776_03185	ENOG410803B	Involved in the transcription termination process (By similarity)
EB776_03190	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
EB776_03195	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EB776_03205	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EB776_03210	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EB776_03220	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
EB776_03225	ENOG4107RSZ	Primosomal protein n'
EB776_03230	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EB776_03240	ENOG4105DJV	ribulose-phosphate 3-epimerase
EB776_03245	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
EB776_03250	ENOG4107XKF	NMT1 THI5 Like Domain Protein
EB776_03255	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
EB776_03260	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
EB776_03290	ENOG4105CQR	helicase
EB776_03300	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
EB776_03340	ENOG4105CTQ	phosphohexokinase
EB776_03345	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EB776_03350	ENOG4105CAT	Cytidine monophosphate kinase
EB776_03360	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
EB776_03365	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
EB776_03385	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EB776_03405	ENOG4105CP7	Triose-phosphate isomerase
EB776_03410	ENOG4105BZA	Phosphoglycerate kinase
EB776_03415	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EB776_03420	ENOG4105CIE	May be required for sporulation (By similarity)
EB776_03430	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
EB776_03435	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EB776_03440	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EB776_03450	ENOG4105DHU	Bile acid
EB776_03460	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EB776_03465	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EB776_03470	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
EB776_03475	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_03510	ENOG4105CA9	Pyruvate kinase
EB776_03515	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
EB776_03520	ENOG4105DK0	Indole-3-glycerol phosphate synthase
EB776_03525	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
EB776_03530	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
EB776_03545	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
EB776_03550	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
EB776_03555	ENOG4105E5F	proteasome
EB776_03560	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
EB776_03575	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
EB776_03580	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
EB776_03595	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EB776_03600	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
EB776_03605	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EB776_03610	ENOG4105E2X	shikimate dehydrogenase
EB776_03630	ENOG4105C0B	DNA polymerase III (alpha subunit)
EB776_03645	ENOG4108V1U	phospholipid-binding protein
EB776_03650	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EB776_03680	ENOG4105DKW	ABC transporter
EB776_03685	ENOG4107QPH	glycogen) synthase
EB776_03690	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
EB776_03695	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EB776_03700	ENOG4105EAC	phosphoserine phosphatase
EB776_03710	ENOG4105C5H	ABC transporter
EB776_03715	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
EB776_03720	ENOG4105VG1	fes assembly suf system protein
EB776_03735	ENOG4105C3K	feS assembly ATPase SufC
EB776_03765	ENOG4105CJR	Integral membrane protein (MviN
EB776_03785	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EB776_03790	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EB776_03800	ENOG4105DSU	hydrolase
EB776_03830	ENOG4105CC5	ABC transporter
EB776_03835	ENOG4107RPQ	ABC transporter
EB776_03840	ENOG4105DIK	(ABC) transporter
EB776_03845	ENOG4107SIG	periplasmic solute binding protein
EB776_03850	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EB776_03865	ENOG4105VZ8	Transcriptional regulator
EB776_03875	ENOG4105CMR	udp-glucose 4-epimerase
EB776_03880	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
EB776_03895	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EB776_03900	ENOG4108Z66	YbaK ebsC protein
EB776_03905	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EB776_03910	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EB776_03915	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EB776_03920	ENOG4108RWN	rrna methyltransferase
EB776_03930	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EB776_03935	ENOG41084BS	50S ribosomal protein L35
EB776_03940	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EB776_03950	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
EB776_03955	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
EB776_03965	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
EB776_03975	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
EB776_03980	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EB776_03985	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
EB776_03990	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EB776_04025	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EB776_04035	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EB776_04040	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EB776_04045	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
EB776_04065	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
EB776_04070	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EB776_04095	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
EB776_04100	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EB776_04105	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EB776_04125	ENOG4105D7A	ATP-binding protein
EB776_04140	ENOG4105C8T	Leucyl-tRNA synthetase
EB776_04165	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
EB776_04170	ENOG4107RPQ	ABC transporter
EB776_04175	ENOG4107104	thymidine kinase
EB776_04195	ENOG4107SIG	periplasmic solute binding protein
EB776_04210	ENOG4105CC5	ABC transporter
EB776_04225	ENOG410841Q	phosphoesterase PA-phosphatase related protein
EB776_04245	ENOG4105C85	amino acid
EB776_04250	ENOG4107GFK	fumarate
EB776_04260	ENOG4108UMI	ABC transporter, permease
EB776_04265	ENOG4105D01	(LipO)protein
EB776_04270	ENOG4105C85	amino acid
EB776_04280	ENOG4108UMN	azlc family
EB776_04285	ENOG4107YCY	Transcriptional regulator
EB776_04300	ENOG4105CFP	Peptidase U32
EB776_04310	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
EB776_04315	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
EB776_04320	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EB776_04360	ENOG4107VMI	polysaccharide deacetylase
EB776_04365	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EB776_04370	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_04375	ENOG4105NWF	RbsD or FucU transport
EB776_04380	ENOG4105EDR	glucose galactose transporter
EB776_04385	ENOG4105FB2	class II Aldolase
EB776_04415	ENOG4108ZM9	phosphoglycerate mutase
EB776_04420	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
EB776_04430	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EB776_04435	ENOG41080RH	Thioredoxin
EB776_04445	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EB776_04450	ENOG4105K46	50S ribosomal protein l27
EB776_04455	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
EB776_04460	ENOG4105C03	ribonuclease
EB776_04470	ENOG4105C4M	(Ubiquinol oxidase) subunit I
EB776_04475	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EB776_04480	ENOG4108JJ9	ABC, transporter
EB776_04485	ENOG4108JJ8	(ABC) transporter
EB776_04495	ENOG4105BZ1	(ABC) transporter
EB776_04500	ENOG4105BZ1	(ABC) transporter
EB776_04505	ENOG4105D3R	alkyl hydroperoxide reductase
EB776_04510	ENOG4108JU3	Alkyl hydroperoxide reductase
EB776_04520	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
EB776_04525	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EB776_04540	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EB776_04555	ENOG4105VB9	50S ribosomal protein l28
EB776_04565	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
EB776_04575	ENOG4105CPF	Cell wall formation (By similarity)
EB776_04580	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EB776_04590	ENOG4105DZW	Dipeptidase
EB776_04600	ENOG4105JNK	Glycosyl transferase (Group 1
EB776_04615	ENOG4105CSC	Glucose uptake protein
EB776_04620	ENOG4105DGW	oligopeptidase A
EB776_04655	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_04665	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EB776_04670	ENOG4105C87	Aminotransferase class I and II
EB776_04675	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
EB776_04705	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EB776_04710	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
EB776_04720	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
EB776_04730	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
EB776_04750	ENOG4108426	dNA-binding protein
EB776_04755	ENOG4107WGA	YidE YbjL
EB776_04770	ENOG4105C4K	Nad synthetase
EB776_04860	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EB776_04865	ENOG4105DR5	peptidase
EB776_04870	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
EB776_04875	ENOG4105CAK	Cell division ATP-binding protein ftsE
EB776_04880	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
EB776_04940	ENOG4105C1J	atp-dependent rna helicase
EB776_04945	ENOG41081FY	multiple antibiotic resistance (MarC)-related
EB776_04955	ENOG4107T6F	Xaa-Pro aminopeptidase
EB776_04960	ENOG4105CJW	magnesium transporter
EB776_04985	ENOG4108URH	decarboxylase
EB776_04995	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
EB776_05000	ENOG4105KBX	Transcriptional regulator, TetR family
EB776_05005	ENOG4105E5M	Multidrug resistance protein D
EB776_05010	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
EB776_05035	ENOG4105UIB	(ABC) transporter
EB776_05040	ENOG4108JQ9	ABC transporter
EB776_05045	ENOG4105DIH	basic membrane
EB776_05050	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
EB776_05065	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
EB776_05070	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EB776_05080	ENOG4107ZYJ	bioY protein
EB776_05090	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
EB776_05095	ENOG4105D8K	carboxyl transferase
EB776_05100	ENOG4108JIK	carboxylase
EB776_05120	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
EB776_05125	ENOG4105C10	Electron transfer flavoprotein
EB776_05140	ENOG4105C5X	domain protein
EB776_05145	ENOG4105C54	Major Facilitator superfamily
EB776_05155	ENOG4105CEY	Amp-dependent synthetase and ligase
EB776_05180	ENOG4108UW5	maltose o-acetyltransferase
EB776_05190	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EB776_05200	ENOG4107QP8	phosphohexose isomerase
EB776_05205	ENOG4105CTQ	phosphohexokinase
EB776_05235	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
EB776_05240	ENOG4105EXC	Acyl-transferase
EB776_05290	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EB776_05305	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EB776_05310	ENOG4105DR9	pseudouridine synthase
EB776_05315	ENOG4105C6K	Malic enzyme
EB776_05320	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
EB776_05335	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_05345	ENOG4105C9Q	fumarate hydratase class II
EB776_05350	ENOG4107QVP	Dehydrogenase
EB776_05360	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EB776_05375	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
EB776_05380	ENOG4105C12	Phosphoribosylglycinamide synthetase
EB776_05385	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
EB776_05390	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
EB776_05395	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
EB776_05400	ENOG4105C8V	SAICAR synthetase
EB776_05405	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
EB776_05415	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EB776_05425	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
EB776_05430	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EB776_05435	ENOG4105C8J	)-transporter
EB776_05445	ENOG4105E33	succinate dehydrogenase
EB776_05475	ENOG4108097	ATP-binding protein
EB776_05480	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EB776_05490	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EB776_05495	ENOG4105CS9	pantothenic acid kinase
EB776_05505	ENOG4108UJD	30S ribosomal protein S9
EB776_05510	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EB776_05520	ENOG4108V7D	UPF0397 protein
EB776_05525	ENOG4108JJB	ABC transporter
EB776_05535	ENOG4105JQN	Transcriptional regulator
EB776_05545	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EB776_05550	ENOG4105DFK	Polyphosphate glucokinase
EB776_05560	ENOG4105E5Q	amino acid AbC transporter
EB776_05565	ENOG4108JEH	abc transporter atp-binding protein
EB776_05570	ENOG4107TXC	Transcriptional regulator
EB776_05575	ENOG4108VPT	UPF0234 protein
EB776_05580	ENOG4108ZT0	50S ribosomal protein l17
EB776_05585	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EB776_05595	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EB776_05600	ENOG41067V7	50S ribosomal protein L36
EB776_05605	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EB776_05615	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EB776_05625	ENOG4107ZG5	Binds to the 23S rRNA (By similarity)
EB776_05630	ENOG4105VPB	50S ribosomal protein L30
EB776_05635	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EB776_05645	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EB776_05650	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EB776_05655	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EB776_05660	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EB776_05665	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EB776_05670	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EB776_05675	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EB776_05685	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EB776_05690	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EB776_05695	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EB776_05700	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
EB776_05705	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EB776_05710	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EB776_05715	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EB776_05720	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EB776_05725	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EB776_05730	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EB776_05740	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EB776_05745	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EB776_05750	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EB776_05755	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EB776_05760	ENOG4108IQI	permease
EB776_05765	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EB776_05770	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EB776_05775	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EB776_05780	ENOG4108VZM	50s ribosomal protein L10
EB776_05790	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EB776_05795	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EB776_05800	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
EB776_05825	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
EB776_05840	ENOG4107R4N	Cell wall formation (By similarity)
EB776_05855	ENOG4105WDJ	50S ribosomal protein L33
EB776_05875	ENOG4108VPT	UPF0234 protein
EB776_05885	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
EB776_05890	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
EB776_05895	ENOG4108T3R	lipoprotein lpqB
EB776_05900	ENOG4105BZU	Histidine kinase
EB776_05905	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EB776_05925	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EB776_05965	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
EB776_05980	ENOG4105C09	Bile acid
EB776_05985	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
EB776_06010	ENOG4107RGC	Glycosyl transferase, family 2
EB776_06020	ENOG4105EY8	ABC transporter
EB776_06045	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
EB776_06105	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
EB776_06115	ENOG4107RGC	Glycosyl transferase, family 2
EB776_06120	ENOG4108KGH	TRANSCRIPTIONal
EB776_06125	ENOG4108KGH	TRANSCRIPTIONal
EB776_06140	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EB776_06155	ENOG4107WR6	Maf-like protein
EB776_06175	ENOG4108Z4U	Ferredoxin
EB776_06190	ENOG4105CI3	gtp-binding protein typa
EB776_06200	ENOG4105BZ1	(ABC) transporter
EB776_06230	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
EB776_06235	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
EB776_06245	ENOG4105DFM	M18 family aminopeptidase
EB776_06260	ENOG4105E9K	Isocitrate dehydrogenase
EB776_06265	ENOG4105CUC	YeeE YedE family protein
EB776_06275	ENOG4105CG3	alpha amylase, catalytic region
EB776_06280	ENOG4105CJQ	hydrolase, family 31
EB776_06290	ENOG4105DRS	transport system, permease
EB776_06295	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
EB776_06300	ENOG4105E2R	ROK family
EB776_06305	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_06330	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EB776_06360	ENOG4108JQ7	(ABC) transporter
EB776_06370	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EB776_06385	ENOG4105TMB	Formate nitrite transporter
EB776_06395	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EB776_06400	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
EB776_06425	ENOG410645S	MarR family Transcriptional regulator
EB776_06430	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
EB776_06440	ENOG4108YYH	Nadph-dependent fmn reductase
EB776_06445	ENOG4108RFG	Tetr family transcriptional regulator
EB776_06450	ENOG4105CSH	Transporter
EB776_06470	ENOG4105DBV	ornithine carbamoyltransferase
EB776_06475	ENOG4105CEU	Arginine dihydrolase
EB776_06490	ENOG4105DRS	transport system, permease
EB776_06500	ENOG4105BZ7	extracellular solute-binding protein family 1
EB776_06505	ENOG4105CG3	alpha amylase, catalytic region
EB776_06515	ENOG4105CH2	amidohydrolase
EB776_06520	ENOG4105CSH	Transporter
EB776_06550	ENOG4105C3G	gtp-binding protein
EB776_06555	ENOG4105CGY	Dna recombination protein
EB776_06560	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
EB776_06575	ENOG4108IUW	ABC transporter
EB776_06590	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
EB776_06600	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EB776_06605	ENOG4105D7K	pfkb domain protein
EB776_06610	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
EB776_06620	ENOG4105T1M	mycothiol conjugate amidase mca
EB776_06625	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EB776_06630	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EB776_06645	ENOG4105CK7	Sodium proline symporter
EB776_06650	ENOG4105C26	Dehydrogenase
EB776_06665	ENOG4105CZV	ABC transporter
EB776_06670	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
EB776_06695	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EB776_06715	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EB776_06730	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EB776_06740	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EB776_06745	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EB776_06755	ENOG4108IG5	Transcriptional regulator
EB776_06770	ENOG4108IUX	(ABC) transporter
EB776_06775	ENOG4105RHA	ABC transporter, permease
EB776_06785	ENOG4105C5H	ABC transporter
EB776_06790	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EB776_06795	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EB776_06805	ENOG4105F8V	Hydrolase, tatD family
EB776_06810	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
EB776_06815	ENOG4108RWI	nicotinamidase
EB776_06855	ENOG4105DA5	(ABC) transporter
EB776_06870	ENOG4107RNR	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity)
EB776_06875	ENOG4105C94	Transporter
EB776_06895	ENOG4105CRK	lysyL-tRNA synthetase
EB776_06900	ENOG4105DAA	L-lactate
EB776_06905	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EB776_06910	ENOG4107QR9	Iron-sulfur cluster binding protein
EB776_06915	ENOG41080R8	Conserved Protein
EB776_06935	ENOG41082BZ	phosphocarrier protein (HPr)
EB776_06940	ENOG4105C5Y	PTS System
EB776_06975	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
EB776_06995	ENOG4105ECB	domain protein
EB776_07005	ENOG4105CAG	UPF0210 protein
EB776_07010	ENOG4105VUC	UPF0237 protein
EB776_07025	ENOG4108638	50S ribosomal protein L36
EB776_07030	ENOG4105NRA	50s ribosomal protein l31 type b
EB776_07035	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EB776_07040	ENOG4105W0E	50S ribosomal protein L33
EB776_07045	ENOG4105KDC	50s ribosomal protein l28
EB776_07070	ENOG4105FDP	GntR family transcriptional regulator
EB776_07075	ENOG4105E0A	ABC, transporter
EB776_07080	ENOG4108U1V	ABC transporter, permease
EB776_07085	ENOG4105EHG	Permease protein
EB776_07090	ENOG4108HUF	Transporter
EB776_07105	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
EB776_07125	ENOG4105YES	addiction module antidote protein
EB776_07200	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
EB776_07205	ENOG4105C7N	Xanthine uracil vitamin C permease
EB776_07210	ENOG4105EIP	mannose-6-phosphate isomerase
EB776_07220	ENOG4105VEQ	Cold shock protein
EB776_07240	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EB776_07245	ENOG4105BZU	Histidine kinase
EB776_07255	ENOG4105PDP	Short chain dehydrogenase
EB776_07270	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EB776_07285	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
EB776_07320	ENOG4108IJ9	(ABC) transporter
EB776_07330	ENOG4105CK5	oxidoreductase
EB776_07340	ENOG4105WEM	extracellular solute-binding protein
EB776_07345	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
EB776_07370	ENOG4105CFH	Aspartokinase
EB776_07375	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EB776_07390	ENOG4105D22	carbon starvation protein
EB776_07415	ENOG4105C2W	permease
EB776_07435	ENOG4105C8N	cysteinyl-tRNA synthetase
EB776_07445	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_07470	ENOG4105CMT	Dihydroxyacetone kinase
EB776_07480	ENOG4107W7X	Aldolase
EB776_07485	ENOG4105DT3	PTS system, galactitol-specific IIc component
EB776_07515	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
EB776_07520	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
EB776_07535	ENOG4105BZU	Histidine kinase
EB776_07545	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EB776_07590	ENOG4105E0A	ABC, transporter
EB776_07595	ENOG4105EHG	Permease protein
EB776_07605	ENOG4107RES	phosphoglycerol transferase I
EB776_07620	ENOG4105VE1	Phosphatidylcholine synthase
EB776_07625	ENOG4107QT5	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
EB776_07630	ENOG4105CPC	Aldo Keto reductase
EB776_07640	ENOG4105FF2	Type I DHQase
EB776_07670	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EB776_07685	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EB776_07690	ENOG41082T9	Membrane
EB776_07695	ENOG4107QTF	adenylosuccinate lyase
EB776_07700	ENOG4107T5V	SNARE associated Golgi
EB776_07735	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
EB776_07740	ENOG4105DQ5	transport system permease protein
EB776_07745	ENOG4105TVJ	transport system, permease
EB776_07750	ENOG4105E0A	ABC, transporter
EB776_07770	ENOG4105CPQ	Dehydrogenase
EB776_07775	ENOG4107QNK	)-transporter
EB776_07785	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
EB776_07800	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EB776_07820	ENOG4105DH8	myo-inositol catabolism
EB776_07825	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
EB776_07830	ENOG4105C26	Dehydrogenase
EB776_07835	ENOG4108IPW	abc transporter atp-binding protein
EB776_07840	ENOG4105CM4	permease protein
EB776_07845	ENOG4105DHS	permease protein
EB776_07850	ENOG4108MES	Periplasmic binding protein
EB776_07855	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
EB776_07860	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
EB776_07870	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
EB776_07875	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
EB776_07880	ENOG4105CPQ	Dehydrogenase
EB776_07885	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EB776_07890	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EB776_07895	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EB776_07900	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EB776_07905	ENOG4105D2H	Uronic isomerase
EB776_07920	ENOG4106N3A	copper homeostasis protein cutc
EB776_07935	ENOG4108NZE	NAGC-like transcriptional regulator
EB776_07950	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EB776_07960	ENOG4105DKQ	ROK family
EB776_07965	ENOG4105E2R	ROK family
EB776_08065	ENOG4108JJB	ABC transporter
EB776_08070	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
EB776_08085	ENOG4105C8P	)-transporter
EB776_08125	ENOG4105CEP	NADH dehydrogenase
EB776_08130	ENOG4108UVJ	appr-1-p processing domain protein
EB776_08175	ENOG4105CQ7	ATP-dependent helicase
EB776_08190	ENOG4105CZN	Potassium uptake protein
EB776_08230	ENOG4107RBB	ABC transporter, permease
EB776_08235	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EB776_08250	ENOG4105F44	Two component transcriptional regulator, winged helix family
EB776_08255	ENOG4106F60	Histidine kinase
EB776_08260	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
EB776_08270	ENOG4105ZMH	deoxynucleoside kinase
EB776_08310	ENOG4105CV8	reductase
EB776_08315	ENOG4105DWF	phosphomethylpyrimidine kinase
EB776_08325	ENOG4105CUZ	uba thif-type nad fad binding protein
EB776_08335	ENOG4107Y80	Major Facilitator superfamily
EB776_08340	ENOG4105CDU	Replicative dna helicase
EB776_08360	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EB776_08365	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
EB776_08370	ENOG4107YH6	single-stranded DNA-binding protein
EB776_08375	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
EB776_08380	ENOG4105BZ4	penicillin-binding protein
EB776_08385	ENOG4105DSF	transport protein
EB776_08395	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EB776_08415	ENOG4105C3M	thioredoxin reductase
EB776_08420	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EB776_08425	ENOG4105CPF	Cell wall formation (By similarity)
EB776_08435	ENOG4107QJE	Chromosome Partitioning Protein
EB776_08440	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
EB776_08450	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EB776_08455	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
EB776_08470	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EB776_08475	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EB776_08480	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EB776_08490	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EB776_08495	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EB776_08535	ENOG4107ZXI	Rhomboid family
EB776_08540	ENOG4105ZJT	Cell division protein CrgA
EB776_08545	ENOG4108RN7	integral membrane protein
EB776_08550	ENOG4105D9P	serine threonine protein kinase
EB776_08570	ENOG4105HZM	Fha domain containing protein
EB776_08575	ENOG4105IDI	abc transporter atp-binding protein
EB776_08595	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EB776_08605	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
EB776_08610	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
EB776_08625	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
EB776_08630	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EB776_08635	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EB776_08645	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EB776_08650	ENOG4107ZF2	Phosphatase
EB776_08665	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
EB776_08670	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
EB776_08690	ENOG4105H3G	oxidoreductase
EB776_08700	ENOG4105CQ7	ATP-dependent helicase
EB776_08705	ENOG4108S01	response regulator
EB776_08710	ENOG4108ZGX	Histidine kinase
EB776_08720	ENOG4108M15	ABC transporter
EB776_08730	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EB776_08740	ENOG4105WH1	Two component transcriptional regulator luxr family
EB776_08745	ENOG4105DSB	aldose 1-epimerase
EB776_08750	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
EB776_08755	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
EB776_08770	ENOG4105D5T	phosphonate abc transporter
EB776_08775	ENOG4108FUF	Transcriptional regulator, IclR family
EB776_08780	ENOG4105DEI	Mannitol dehydrogenase
EB776_08785	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
EB776_08790	ENOG4108UHU	Aldolase
EB776_08795	ENOG4105D7K	pfkb domain protein
EB776_08800	ENOG4105DXX	methyltransferase
EB776_08810	ENOG4105E0A	ABC, transporter
EB776_08820	ENOG4105DQ5	transport system permease protein
EB776_08835	ENOG4105BZ1	(ABC) transporter
EB776_08840	ENOG4108JJ8	(ABC) transporter
EB776_08845	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_08860	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
EB776_08865	ENOG4105I1K	ABC transporter
EB776_08915	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
EB776_08945	ENOG4105CNN	ABC, transporter
EB776_08950	ENOG4105D4B	ABC, transporter
EB776_08990	ENOG4108KP7	hydrolase
EB776_08995	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EB776_09010	ENOG4105CQC	Prephenate dehydratase
EB776_09035	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
EB776_09040	ENOG4108Z6B	deaminase
EB776_09050	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
EB776_09055	ENOG4105DPH	UPF0371 protein
EB776_09060	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
EB776_09110	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
EB776_09120	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EB776_09130	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EB776_09140	ENOG4108IUK	alpha amylase, catalytic
EB776_09155	ENOG4105BZ4	penicillin-binding protein
EB776_09190	ENOG4105D74	hydrolase
EB776_09235	ENOG4108I5C	dEAD DEAH box helicase
EB776_09240	ENOG4105VMP	Transcriptional regulator
EB776_09250	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
EB776_09255	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
EB776_09260	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
EB776_09265	ENOG4105C6E	dna polymerase iii
EB776_09280	ENOG4105CMM	transposase
EB776_09320	ENOG4105DHP	deoxycytidine triphosphate deaminase
EB776_09325	ENOG4105D65	subunit l
EB776_09330	ENOG4105MKQ	Monovalent cation H antiporter subunit C
EB776_09335	ENOG4108JPZ	Monovalent cation H antiporter subunit D
EB776_09360	ENOG4105DP9	ABC transporter
EB776_09365	ENOG4105E0C	molybdate abc transporter
EB776_09370	ENOG4108UCS	ABC, transporter
EB776_09385	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
EB776_09420	ENOG4105DKQ	ROK family
EB776_09425	ENOG4105C4B	ABC transporter, permease
EB776_09445	ENOG4105QAX	Iron-sulfur
EB776_09450	ENOG4107QY8	reductase
EB776_09460	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
EB776_09470	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
EB776_09475	ENOG4105CXT	aspartate transcarbamylase
EB776_09480	ENOG4105CD3	dihydroorotase
EB776_09485	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
EB776_09490	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EB776_09495	ENOG4105CS7	Catalyzes the conversion of dihydroorotate to orotate
EB776_09500	ENOG4105CFG	Acts as a chaperone (By similarity)
EB776_09505	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EB776_09510	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EB776_09515	ENOG4105KNI	merR family transcriptional Regulator
EB776_09535	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
EB776_09540	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
EB776_09550	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
EB776_09560	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EB776_09595	ENOG4105M6F	mutator MutT protein
EB776_09610	ENOG4107RCW	fructose-bisphosphate aldolase
EB776_09620	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EB776_09625	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
EB776_09630	ENOG4105C8V	SAICAR synthetase
EB776_09635	ENOG4105D82	Glutamate dehydrogenase
EB776_09665	ENOG4105C94	Transporter
EB776_09695	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EB776_09700	ENOG4105CJR	Integral membrane protein (MviN
EB776_09725	ENOG4105E0X	reductase
EB776_09750	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
EB776_09760	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
EB776_09775	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EB776_09780	ENOG4105CJ3	phosphate transporter
EB776_09800	ENOG4105CGH	5'-nucleotidase
EB776_09810	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
EB776_09815	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
EB776_09825	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
EB776_09830	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EB776_09835	ENOG4108RVA	ribokinase
EB776_09845	ENOG4105EDR	glucose galactose transporter
EB776_09850	ENOG4107RHR	regulatoR
EB776_09860	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
EB776_09865	ENOG4105CMG	Carbohydrate kinase
EB776_09870	ENOG4108ZYE	Transcriptional regulator
EB776_09880	ENOG4105EF1	ribulokinase
EB776_09890	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EB776_09895	ENOG4105CMT	Dihydroxyacetone kinase
EB776_09905	ENOG4107YVI	ribose 5-phosphate isomerase
EB776_09910	ENOG4108VCT	Sulfite exporter TauE/SafE
EB776_09915	ENOG4105C4X	radical SAM domain protein
EB776_09920	ENOG4105C54	Major Facilitator superfamily
EB776_09925	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_09930	ENOG4105CBG	Sulfatase
EB776_09950	ENOG4108I5D	sulfate abc transporter
EB776_09955	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EB776_09965	ENOG4105C93	Xylose Isomerase
EB776_09975	ENOG410769Z	extracellular solute-binding protein family 1
EB776_09980	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
EB776_09985	ENOG4105DRS	transport system, permease
EB776_09990	ENOG4105CBG	Sulfatase
EB776_10000	ENOG4105DKT	Transcriptional regulator
EB776_10005	ENOG4105C6Z	Gluconate
EB776_10015	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
EB776_10025	ENOG4105E2D	ec 3.2.1.52
EB776_10030	ENOG4105CNT	hydrolase family 2
EB776_10035	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
EB776_10045	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
EB776_10050	ENOG4105CNN	ABC, transporter
EB776_10055	ENOG4105C2J	ABC transporter
EB776_10060	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_10065	ENOG4105DVA	methyltransferase
EB776_10070	ENOG4105D7T	ABC transporter
EB776_10090	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
EB776_10100	ENOG4105ETE	Transcriptional regulator (LacI family
EB776_10105	ENOG4105C54	Major Facilitator superfamily
EB776_10110	ENOG4105KT7	mgtC SapB transporter
EB776_10135	ENOG4105CJ1	ABC, transporter
EB776_10170	ENOG4106H3A	restriction
EB776_10200	ENOG4105D85	methylase
EB776_10245	ENOG4107Y5K	Resolvase
EB776_10335	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EB776_10340	ENOG4105EFC	phage portal protein HK97 family
EB776_10345	ENOG4105CAR	Terminase, large subunit
EB776_10435	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
EB776_10485	ENOG4105C2M	dna polymerase I