locus-tag	class	description
X956_00050	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
X956_00055	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
X956_00065	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
X956_00070	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
X956_00075	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
X956_00095	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
X956_00110	ENOG4107QJE	Chromosome Partitioning Protein
X956_00120	ENOG4105CPF	Cell wall formation (By similarity)
X956_00125	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
X956_00130	ENOG4105C3M	thioredoxin reductase
X956_00160	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
X956_00165	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
X956_00170	ENOG4107YH6	single-stranded DNA-binding protein
X956_00175	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
X956_00195	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
X956_00210	ENOG4107Y80	Major Facilitator superfamily
X956_00215	ENOG4105CDU	Replicative dna helicase
X956_00230	ENOG4105CUZ	uba thif-type nad fad binding protein
X956_00245	ENOG4105DWF	phosphomethylpyrimidine kinase
X956_00250	ENOG4105CV8	reductase
X956_00290	ENOG4105ZMH	deoxynucleoside kinase
X956_00300	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
X956_00310	ENOG4105F44	Two component transcriptional regulator, winged helix family
X956_00320	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
X956_00350	ENOG4105CZN	Potassium uptake protein
X956_00370	ENOG4105ETE	Transcriptional regulator (LacI family
X956_00375	ENOG4105C54	Major Facilitator superfamily
X956_00380	ENOG4105KT7	mgtC SapB transporter
X956_00405	ENOG4105CJ1	ABC, transporter
X956_00425	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
X956_00435	ENOG4105D4B	ABC, transporter
X956_00445	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
X956_00455	ENOG41061GT	Aldolase
X956_00475	ENOG4105CEP	NADH dehydrogenase
X956_00480	ENOG4108UVJ	appr-1-p processing domain protein
X956_00525	ENOG4105C8P	)-transporter
X956_00540	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
X956_00545	ENOG4108JJB	ABC transporter
X956_00640	ENOG4105E2R	ROK family
X956_00645	ENOG4105DKQ	ROK family
X956_00655	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
X956_00670	ENOG4108NZE	NAGC-like transcriptional regulator
X956_00685	ENOG4106N3A	copper homeostasis protein cutc
X956_00700	ENOG4105D2H	Uronic isomerase
X956_00705	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
X956_00710	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
X956_00715	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
X956_00720	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
X956_00725	ENOG4108MES	Periplasmic binding protein
X956_00730	ENOG4105DHS	permease protein
X956_00735	ENOG4105CM4	permease protein
X956_00740	ENOG4108IPW	abc transporter atp-binding protein
X956_00745	ENOG4105C26	Dehydrogenase
X956_00750	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
X956_00755	ENOG4105DH8	myo-inositol catabolism
X956_00775	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
X956_00790	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
X956_00800	ENOG4105CNN	ABC, transporter
X956_00805	ENOG4105D4B	ABC, transporter
X956_00810	ENOG4105ECY	inositol monophosphatase
X956_00815	ENOG4105CXY	transporter
X956_00825	ENOG4105CPQ	Dehydrogenase
X956_00845	ENOG4108JJB	ABC transporter
X956_00850	ENOG4105BZ1	(ABC) transporter
X956_00905	ENOG4107T5V	SNARE associated Golgi
X956_00910	ENOG4107QTF	adenylosuccinate lyase
X956_00915	ENOG41082T9	Membrane
X956_00920	ENOG4105CIH	Imidazole acetol-phosphate transaminase
X956_00935	ENOG4105FF2	Type I DHQase
X956_00945	ENOG4105CPC	Aldo Keto reductase
X956_00950	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
X956_00955	ENOG4105VE1	Phosphatidylcholine synthase
X956_00970	ENOG4107RES	phosphoglycerol transferase I
X956_00980	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
X956_00985	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
X956_00995	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
X956_01015	ENOG4105EHG	Permease protein
X956_01020	ENOG4105E0A	ABC, transporter
X956_01070	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
X956_01075	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
X956_01080	ENOG4105BZU	Histidine kinase
X956_01095	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
X956_01100	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
X956_01120	ENOG4105CMT	Dihydroxyacetone kinase
X956_01130	ENOG4107W7X	Aldolase
X956_01135	ENOG4105DT3	PTS system, galactitol-specific IIc component
X956_01150	ENOG4105CMT	Dihydroxyacetone kinase
X956_01165	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
X956_01175	ENOG4105C8N	cysteinyl-tRNA synthetase
X956_01195	ENOG4105C2W	permease
X956_01215	ENOG4105D22	carbon starvation protein
X956_01230	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
X956_01235	ENOG4105CFH	Aspartokinase
X956_01270	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
X956_01280	ENOG4105WEM	extracellular solute-binding protein
X956_01290	ENOG4105CK5	oxidoreductase
X956_01300	ENOG4108IJ9	(ABC) transporter
X956_01340	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
X956_01355	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
X956_01365	ENOG4105PDP	Short chain dehydrogenase
X956_01375	ENOG4105BZU	Histidine kinase
X956_01380	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
X956_01400	ENOG4105VEQ	Cold shock protein
X956_01410	ENOG4105EIP	mannose-6-phosphate isomerase
X956_01415	ENOG4105C7N	Xanthine uracil vitamin C permease
X956_01420	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
X956_01490	ENOG4105YES	addiction module antidote protein
X956_01495	ENOG4105VUH	addiction module killer protein
X956_01510	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
X956_01525	ENOG4108HUF	Transporter
X956_01530	ENOG4108U1V	ABC transporter, permease
X956_01535	ENOG4108U1V	ABC transporter, permease
X956_01540	ENOG4105E0A	ABC, transporter
X956_01545	ENOG4105FDP	GntR family transcriptional regulator
X956_01570	ENOG4105KDC	50s ribosomal protein l28
X956_01575	ENOG4105W0E	50S ribosomal protein L33
X956_01580	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
X956_01585	ENOG4105NRA	50s ribosomal protein l31 type b
X956_01590	ENOG4108638	50S ribosomal protein L36
X956_01605	ENOG4105VUC	UPF0237 protein
X956_01610	ENOG4105CAG	UPF0210 protein
X956_01620	ENOG4105ECB	domain protein
X956_01635	ENOG4105CID	antiterminator
X956_01645	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
X956_01675	ENOG4105C5Y	PTS System
X956_01680	ENOG41082BZ	phosphocarrier protein (HPr)
X956_01700	ENOG41080R8	Conserved Protein
X956_01705	ENOG4107QR9	Iron-sulfur cluster binding protein
X956_01710	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
X956_01715	ENOG4105DAA	L-lactate
X956_01720	ENOG4105CRK	lysyL-tRNA synthetase
X956_01740	ENOG4105C94	Transporter
X956_01745	ENOG4107RNR	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity)
X956_01760	ENOG4105DA5	(ABC) transporter
X956_01805	ENOG4108RWI	nicotinamidase
X956_01825	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
X956_01840	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
X956_01845	ENOG4105F8V	Hydrolase, tatD family
X956_01855	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
X956_01860	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
X956_01865	ENOG4105C5H	ABC transporter
X956_01875	ENOG4105RHA	ABC transporter, permease
X956_01880	ENOG4108IUX	(ABC) transporter
X956_01895	ENOG4108IG5	Transcriptional regulator
X956_01905	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
X956_01910	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
X956_01920	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
X956_01935	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
X956_01955	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
X956_01985	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
X956_01990	ENOG4105CZV	ABC transporter
X956_02005	ENOG4105C26	Dehydrogenase
X956_02010	ENOG4105CK7	Sodium proline symporter
X956_02025	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
X956_02030	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
X956_02035	ENOG4105T1M	mycothiol conjugate amidase mca
X956_02045	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
X956_02050	ENOG4105D7K	pfkb domain protein
X956_02055	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
X956_02065	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
X956_02075	ENOG4108IUW	ABC transporter
X956_02090	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
X956_02095	ENOG4105CGY	Dna recombination protein
X956_02100	ENOG4105C3G	gtp-binding protein
X956_02125	ENOG4105CSH	Transporter
X956_02130	ENOG4105CH2	amidohydrolase
X956_02140	ENOG4105CG3	alpha amylase, catalytic region
X956_02145	ENOG4105BZ7	extracellular solute-binding protein family 1
X956_02155	ENOG4105DRS	transport system, permease
X956_02170	ENOG4105CEU	Arginine dihydrolase
X956_02175	ENOG4105DBV	ornithine carbamoyltransferase
X956_02195	ENOG4105CSH	Transporter
X956_02200	ENOG4108RFG	Tetr family transcriptional regulator
X956_02205	ENOG4108YYH	Nadph-dependent fmn reductase
X956_02215	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
X956_02240	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
X956_02245	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
X956_02255	ENOG4105TMB	Formate nitrite transporter
X956_02270	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
X956_02280	ENOG4108JQ7	(ABC) transporter
X956_02310	ENOG4105DKQ	ROK family
X956_02320	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
X956_02355	ENOG4105E2R	ROK family
X956_02360	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
X956_02365	ENOG4105DRS	transport system, permease
X956_02375	ENOG4105CJQ	hydrolase, family 31
X956_02380	ENOG4105CG3	alpha amylase, catalytic region
X956_02390	ENOG4105CUC	YeeE YedE family protein
X956_02395	ENOG4105E9K	Isocitrate dehydrogenase
X956_02435	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
X956_02440	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
X956_02450	ENOG4105DFM	M18 family aminopeptidase
X956_02460	ENOG4105BZ1	(ABC) transporter
X956_02470	ENOG4105CI3	gtp-binding protein typa
X956_02485	ENOG4108Z4U	Ferredoxin
X956_02505	ENOG4107WR6	Maf-like protein
X956_02520	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
X956_02535	ENOG4108KGH	TRANSCRIPTIONal
X956_02540	ENOG4108KGH	TRANSCRIPTIONal
X956_02545	ENOG4107RGC	Glycosyl transferase, family 2
X956_02555	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
X956_02615	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
X956_02630	ENOG4108IJ1	Dehydrogenase
X956_02640	ENOG4105EY8	ABC transporter
X956_02650	ENOG4107RGC	Glycosyl transferase, family 2
X956_02675	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
X956_02680	ENOG4105C09	Bile acid
X956_02695	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
X956_02740	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
X956_02760	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
X956_02765	ENOG4105BZU	Histidine kinase
X956_02780	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
X956_02785	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
X956_02795	ENOG4108VPT	UPF0234 protein
X956_02815	ENOG4105WDJ	50S ribosomal protein L33
X956_02830	ENOG4107R4N	Cell wall formation (By similarity)
X956_02845	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
X956_02870	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
X956_02875	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
X956_02880	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
X956_02895	ENOG4105DBI	uridine monophosphokinase
X956_02900	ENOG4108VZM	50s ribosomal protein L10
X956_02905	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
X956_02910	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
X956_02915	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
X956_02935	ENOG4108IQI	permease
X956_02940	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
X956_02945	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
X956_02950	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
X956_02955	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
X956_02970	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
X956_02975	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
X956_02980	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
X956_02985	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
X956_02990	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X956_02995	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
X956_03000	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
X956_03005	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
X956_03010	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
X956_03020	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
X956_03025	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
X956_03030	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
X956_03035	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X956_03040	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
X956_03045	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
X956_03050	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
X956_03060	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
X956_03065	ENOG4105VPB	50S ribosomal protein L30
X956_03070	ENOG4107ZG5	Binds to the 23S rRNA (By similarity)
X956_03080	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
X956_03090	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
X956_03095	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X956_03105	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
X956_03110	ENOG4108ZT0	50S ribosomal protein l17
X956_03115	ENOG4108VPT	UPF0234 protein
X956_03130	ENOG4108JEH	abc transporter atp-binding protein
X956_03135	ENOG4105E5Q	amino acid AbC transporter
X956_03145	ENOG4105DFK	Polyphosphate glucokinase
X956_03150	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
X956_03165	ENOG4105JQN	Transcriptional regulator
X956_03175	ENOG4108JJB	ABC transporter
X956_03180	ENOG4108V7D	UPF0397 protein
X956_03190	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
X956_03195	ENOG4108UJD	30S ribosomal protein S9
X956_03205	ENOG4105CS9	pantothenic acid kinase
X956_03210	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
X956_03220	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
X956_03225	ENOG4108097	ATP-binding protein
X956_03255	ENOG4105E33	succinate dehydrogenase
X956_03265	ENOG4105C8J	)-transporter
X956_03270	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
X956_03275	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
X956_03285	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
X956_03295	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
X956_03300	ENOG4105C8V	SAICAR synthetase
X956_03305	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
X956_03310	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
X956_03315	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
X956_03320	ENOG4105C12	Phosphoribosylglycinamide synthetase
X956_03325	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
X956_03345	ENOG4107QVP	Dehydrogenase
X956_03355	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
X956_03360	ENOG4107QVP	Dehydrogenase
X956_03365	ENOG4105C9Q	fumarate hydratase class II
X956_03375	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
X956_03390	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
X956_03395	ENOG4105C6K	Malic enzyme
X956_03400	ENOG4105DR9	pseudouridine synthase
X956_03405	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
X956_03445	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
X956_03485	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
X956_03505	ENOG4105EXC	Acyl-transferase
X956_03510	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
X956_03530	ENOG4105DC1	bifunctional purine biosynthesis protein purh
X956_03540	ENOG4105CTQ	phosphohexokinase
X956_03545	ENOG4107QP8	phosphohexose isomerase
X956_03550	ENOG4105NDH	peptidase s1 and s6 chymotrypsin hap
X956_03555	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
X956_03565	ENOG4108UW5	maltose o-acetyltransferase
X956_03590	ENOG4105CEY	Amp-dependent synthetase and ligase
X956_03600	ENOG4105C54	Major Facilitator superfamily
X956_03605	ENOG4105C5X	domain protein
X956_03620	ENOG4105C10	Electron transfer flavoprotein
X956_03625	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
X956_03655	ENOG4107ZYJ	bioY protein
X956_03665	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
X956_03670	ENOG4105D8K	carboxyl transferase
X956_03675	ENOG4108JIK	carboxylase
X956_03685	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
X956_03690	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
X956_03705	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
X956_03710	ENOG4105DIH	basic membrane
X956_03715	ENOG4108JQ9	ABC transporter
X956_03720	ENOG4105UIB	(ABC) transporter
X956_03745	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
X956_03750	ENOG4105E5M	Multidrug resistance protein D
X956_03755	ENOG4105KBX	Transcriptional regulator, TetR family
X956_03760	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
X956_03770	ENOG4108URH	decarboxylase
X956_03795	ENOG4105CJW	magnesium transporter
X956_03800	ENOG4107T6F	Xaa-Pro aminopeptidase
X956_03810	ENOG41081FY	multiple antibiotic resistance (MarC)-related
X956_03815	ENOG4105C1J	atp-dependent rna helicase
X956_03875	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
X956_03880	ENOG4105CAK	Cell division ATP-binding protein ftsE
X956_03885	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
X956_03905	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
X956_03910	ENOG4105MP0	transposase
X956_04170	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
X956_04175	ENOG4105DR5	peptidase
X956_04195	ENOG4105C4K	Nad synthetase
X956_04210	ENOG4107WGA	YidE YbjL
X956_04215	ENOG4108426	dNA-binding protein
X956_04235	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
X956_04245	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
X956_04255	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
X956_04260	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
X956_04290	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
X956_04295	ENOG4105C87	Aminotransferase class I and II
X956_04300	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
X956_04310	ENOG4105ETE	Transcriptional regulator (LacI family
X956_04345	ENOG4105DGW	oligopeptidase A
X956_04350	ENOG4105CSC	Glucose uptake protein
X956_04360	ENOG4105JNK	Glycosyl transferase (Group 1
X956_04370	ENOG4105DZW	Dipeptidase
X956_04380	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
X956_04385	ENOG4105CPF	Cell wall formation (By similarity)
X956_04395	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
X956_04405	ENOG4105VB9	50S ribosomal protein l28
X956_04420	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
X956_04435	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
X956_04440	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
X956_04450	ENOG4108JU3	Alkyl hydroperoxide reductase
X956_04455	ENOG4105D3R	alkyl hydroperoxide reductase
X956_04460	ENOG4105BZ1	(ABC) transporter
X956_04465	ENOG4105BZ1	(ABC) transporter
X956_04475	ENOG4108JJ8	(ABC) transporter
X956_04480	ENOG4108JJ9	ABC, transporter
X956_04485	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
X956_04490	ENOG4105C4M	(Ubiquinol oxidase) subunit I
X956_04495	ENOG4105C03	ribonuclease
X956_04500	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
X956_04505	ENOG4105K46	50S ribosomal protein l27
X956_04510	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X956_04525	ENOG41080RH	Thioredoxin
X956_04530	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
X956_04540	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
X956_04545	ENOG4105CVJ	phosphoglycerate mutase
X956_04580	ENOG4105FB2	class II Aldolase
X956_04585	ENOG4105EDR	glucose galactose transporter
X956_04590	ENOG4105NWF	RbsD or FucU transport
X956_04595	ENOG4105ETE	Transcriptional regulator (LacI family
X956_04600	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
X956_04605	ENOG4107VMI	polysaccharide deacetylase
X956_04650	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
X956_04665	ENOG4105CFP	Peptidase U32
X956_04670	ENOG4108UMN	azlc family
X956_04680	ENOG4105C85	amino acid
X956_04690	ENOG4105D01	(LipO)protein
X956_04695	ENOG4108UMI	ABC transporter, permease
X956_04705	ENOG4107GFK	fumarate
X956_04710	ENOG4105C85	amino acid
X956_04720	ENOG41067QW	Transcriptional regulator
X956_04730	ENOG410841Q	phosphoesterase PA-phosphatase related protein
X956_04750	ENOG4105CC5	ABC transporter
X956_04765	ENOG4107SIG	periplasmic solute binding protein
X956_04785	ENOG4107104	thymidine kinase
X956_04790	ENOG4107RPQ	ABC transporter
X956_04795	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
X956_04820	ENOG4105C8T	Leucyl-tRNA synthetase
X956_04860	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
X956_04865	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
X956_04870	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
X956_04895	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
X956_04900	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
X956_04920	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
X956_04925	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
X956_04930	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
X956_04940	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
X956_04975	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
X956_04980	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
X956_04985	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
X956_04990	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
X956_05000	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
X956_05010	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
X956_05015	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
X956_05025	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
X956_05030	ENOG41084BS	50S ribosomal protein L35
X956_05035	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
X956_05045	ENOG4108RWN	rrna methyltransferase
X956_05060	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
X956_05065	ENOG4108Z66	YbaK ebsC protein
X956_05070	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
X956_05085	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
X956_05090	ENOG4105CMR	udp-glucose 4-epimerase
X956_05100	ENOG4105VZ8	Transcriptional regulator
X956_05110	ENOG4108M15	ABC transporter
X956_05115	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
X956_05120	ENOG4107SIG	periplasmic solute binding protein
X956_05125	ENOG4105DIK	(ABC) transporter
X956_05130	ENOG4107RPQ	ABC transporter
X956_05135	ENOG4105CC5	ABC transporter
X956_05160	ENOG4105DSU	hydrolase
X956_05175	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
X956_05180	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
X956_05200	ENOG4105CJR	Integral membrane protein (MviN
X956_05230	ENOG4105C3K	feS assembly ATPase SufC
X956_05245	ENOG4105VG1	fes assembly suf system protein
X956_05250	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
X956_05255	ENOG4105C5H	ABC transporter
X956_05265	ENOG4105EAC	phosphoserine phosphatase
X956_05275	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
X956_05280	ENOG4107QPH	glycogen) synthase
X956_05285	ENOG4105DKW	ABC transporter
X956_05330	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
X956_05335	ENOG4108V1U	phospholipid-binding protein
X956_05350	ENOG4105C0B	DNA polymerase III (alpha subunit)
X956_05375	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
X956_05380	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
X956_05385	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
X956_05400	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
X956_05405	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
X956_05420	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
X956_05425	ENOG4105E5F	proteasome
X956_05430	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
X956_05435	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
X956_05465	ENOG4105CTQ	phosphohexokinase
X956_05485	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
X956_05490	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
X956_05510	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
X956_05530	ENOG4105CP7	Triose-phosphate isomerase
X956_05535	ENOG4105BZA	Phosphoglycerate kinase
X956_05540	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
X956_05545	ENOG4105CIE	May be required for sporulation (By similarity)
X956_05555	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
X956_05560	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
X956_05565	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
X956_05575	ENOG4105DHU	Bile acid
X956_05585	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
X956_05590	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
X956_05595	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
X956_05600	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
X956_05635	ENOG4105CA9	Pyruvate kinase
X956_05640	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
X956_05645	ENOG4105DK0	Indole-3-glycerol phosphate synthase
X956_05650	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
X956_05685	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
X956_05695	ENOG4105CQR	helicase
X956_05725	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
X956_05730	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
X956_05735	ENOG4107XKF	NMT1 THI5 Like Domain Protein
X956_05740	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
X956_05745	ENOG4105DJV	ribulose-phosphate 3-epimerase
X956_05755	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
X956_05760	ENOG4107RSZ	Primosomal protein n'
X956_05765	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
X956_05775	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
X956_05780	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
X956_05795	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
X956_05800	ENOG410803B	Involved in the transcription termination process (By similarity)
X956_05805	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
X956_05810	ENOG4105C59	p-type ATPase
X956_05815	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
X956_05820	ENOG4105D49	3-dehydroquinate synthase
X956_05825	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
X956_05845	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
X956_05860	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
X956_05870	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
X956_05875	ENOG4107R13	MMPL domain protein
X956_05890	ENOG4105C9M	aspartyl-trna synthetase
X956_05910	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
X956_05915	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
X956_05920	ENOG4105CUT	histidyl-tRNA synthetase
X956_05925	ENOG4105C5X	domain protein
X956_05930	ENOG4105C99	atpase involved in dna repair
X956_05940	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
X956_05945	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
X956_05950	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
X956_05955	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
X956_05965	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
X956_05970	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
X956_05975	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
X956_05980	ENOG4105CDY	transcriptional regulatory protein
X956_05985	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
X956_05995	ENOG4105E2K	Glycosyl transferase (Group 1
X956_06010	ENOG4105C22	threonyL-tRNA synthetase
X956_06015	ENOG4105EJQ	L-serine dehydratase
X956_06020	ENOG4105WH1	Two component transcriptional regulator luxr family
X956_06085	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
X956_06095	ENOG4107QM5	aconitate hydratase
X956_06100	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
X956_06110	ENOG4107VEG	TrkA-N domain protein
X956_06155	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
X956_06170	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
X956_06180	ENOG4105DVT	helicase
X956_06185	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
X956_06220	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
X956_06225	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
X956_06265	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
X956_06325	ENOG4105C5F	glutamine synthetase
X956_06335	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
X956_06340	ENOG4105C5F	glutamine synthetase
X956_06355	ENOG4105DFK	Polyphosphate glucokinase
X956_06375	ENOG4105EGD	dinuclear metal center protein, YbgI family
X956_06380	ENOG41082CG	Protein CrcB homolog
X956_06385	ENOG4108680	CrcB-like protein
X956_06410	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
X956_06430	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
X956_06450	ENOG4105ECP	epimerase
X956_06455	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
X956_06490	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
X956_06495	ENOG4105EHG	Permease protein
X956_06530	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
X956_06535	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
X956_06545	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
X956_06550	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
X956_06570	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
X956_06580	ENOG4105DIK	(ABC) transporter
X956_06585	ENOG4105CC5	ABC transporter
X956_06590	ENOG41090R7	Ferric uptake
X956_06605	ENOG4105C0B	DNA polymerase III (alpha subunit)
X956_06635	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
X956_06645	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
X956_06655	ENOG4105DFU	Cell wall formation (By similarity)
X956_06660	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
X956_06665	ENOG4105CNI	cell division protein FtsW
X956_06670	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
X956_06675	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
X956_06685	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
X956_06690	ENOG4105CJN	penicillin-binding protein
X956_06700	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
X956_06705	ENOG4108V6E	Cell division protein mraZ
X956_06715	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
X956_06735	ENOG4108JQ1	Dehydrogenase
X956_06740	ENOG4105CEY	Amp-dependent synthetase and ligase
X956_06755	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
X956_06765	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
X956_06770	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
X956_06775	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
X956_06780	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
X956_06785	ENOG4105Y3E	Modulates RecA activity (By similarity)
X956_06790	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
X956_06800	ENOG4105WBV	Transcriptional regulator
X956_06805	ENOG4105CEV	competence damage-inducible protein
X956_06820	ENOG4107QZI	cell division protein FtsK
X956_06830	ENOG4105CN5	Metallo-Beta-Lactamase
X956_06835	ENOG4107QZI	cell division protein FtsK
X956_06845	ENOG4105C0D	helicase
X956_06850	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
X956_06855	ENOG4105C1V	Peptidase, M16
X956_06865	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
X956_06870	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
X956_06880	ENOG4105CJ1	ABC, transporter
X956_06890	ENOG4105DTN	riboflavin biosynthesis protein ribF
X956_06895	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
X956_06900	ENOG4105BZU	Histidine kinase
X956_06905	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
X956_06910	ENOG4105CXY	transporter
X956_06920	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
X956_06950	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
X956_06955	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
X956_06970	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
X956_06980	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
X956_06990	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
X956_06995	ENOG4105DZP	Membrane-associated zinc metalloprotease
X956_07000	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
X956_07010	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
X956_07020	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
X956_07025	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
X956_07045	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
X956_07050	ENOG4105C10	Electron transfer flavoprotein
X956_07065	ENOG4105EN6	Membrane
X956_07070	ENOG4108K5P	(LipO)protein
X956_07075	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
X956_07085	ENOG4105C0P	Mg chelatase subunit ChlI
X956_07100	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
X956_07105	ENOG4107QYR	Signal peptidase i
X956_07110	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
X956_07115	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
X956_07120	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
X956_07125	ENOG41082KU	UPF0109 protein
X956_07130	ENOG4105K5M	30s ribosomal protein S16
X956_07155	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
X956_07160	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
X956_07175	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
X956_07180	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
X956_07185	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
X956_07220	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
X956_07225	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
X956_07230	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
X956_07235	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
X956_07240	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
X956_07245	ENOG4105CPC	Aldo Keto reductase
X956_07255	ENOG4105D17	glycoside hydrolase, family 3 domain protein
X956_07260	ENOG4105CT4	transporter
X956_07265	ENOG4105CNT	hydrolase family 2
X956_07270	ENOG4105ETE	Transcriptional regulator (LacI family
X956_07285	ENOG4105C5H	ABC transporter
X956_07300	ENOG4107QN2	dihydrolipoyl dehydrogenase
X956_07315	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
X956_07325	ENOG4105D7W	serine acetyltransferase
X956_07345	ENOG4105C9K	Endothelin-converting enzyme 1
X956_07350	ENOG4105CKW	Inner membrane protein yedI
X956_07360	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
X956_07375	ENOG4105C29	acyl-CoA thioesterase
X956_07405	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
X956_07435	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
X956_07445	ENOG4105KPE	licD family
X956_07475	ENOG4108XUD	Membrane
X956_07495	ENOG4105DFA	alanine racemase domain protein
X956_07510	ENOG4105C6N	Formate acetyltransferase
X956_07515	ENOG4105CM2	brancheD-chain amino acid aminotransferase
X956_07540	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
X956_07545	ENOG4108ZP8	Acetolactate synthase small subunit
X956_07555	ENOG4105D0C	transport protein
X956_07560	ENOG4105C01	Dihydroxy-acid dehydratase
X956_07575	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
X956_07580	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
X956_07585	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
X956_07590	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
X956_07595	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
X956_07600	ENOG4107R3N	Filamentation induced by cAMP protein fic
X956_07605	ENOG4108TFM	Kinase, PfkB family
X956_07615	ENOG4108KD5	ADP-ribosylation crystallin J1
X956_07620	ENOG4105FDP	GntR family transcriptional regulator
X956_07625	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
X956_07630	ENOG4108RAV	Conserved protein
X956_07635	ENOG4105BZU	Histidine kinase
X956_07670	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
X956_07705	ENOG4105EWV	Sodium calcium exchanger membrane region
X956_07715	ENOG4105CZV	ABC transporter
X956_07720	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
X956_07740	ENOG4105ESP	cell wall surface anchor family protein
X956_07745	ENOG4105DJZ	UPF0182 protein
X956_07755	ENOG41063PX	domain protein
X956_07785	ENOG4105C31	Tryptophanyl-tRNA synthetase
X956_07805	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
X956_07815	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
X956_07820	ENOG4105CG3	alpha amylase, catalytic region
X956_07825	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
X956_07830	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
X956_07840	ENOG4105EG2	ABC transporter, permease
X956_07845	ENOG4105D56	permease protein
X956_07855	ENOG4105ETE	Transcriptional regulator (LacI family
X956_07860	ENOG4105CG3	alpha amylase, catalytic region
X956_07900	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
X956_07910	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
X956_07915	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
X956_07920	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
X956_07925	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
X956_07930	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
X956_07935	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
X956_07940	ENOG4105ZA1	atp synthase
X956_07945	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
X956_07965	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
X956_07970	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
X956_07975	ENOG4105VFB	Binds the 23S rRNA (By similarity)
X956_07985	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
X956_07990	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
X956_07995	ENOG4105D6E	homoserine dehydrogenase
X956_08005	ENOG4105C75	arginyL-tRNA synthetase
X956_08025	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
X956_08040	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
X956_08045	ENOG4105DR5	peptidase
X956_08060	ENOG4105C37	(CBS) domain
X956_08065	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
X956_08090	ENOG4105EMN	RNA polymerase sigma factor
X956_08095	ENOG4105CE4	GlcNAc 6-P deacetylase
X956_08100	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
X956_08105	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
X956_08135	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
X956_08150	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
X956_08155	ENOG4105C3U	ABC transporter
X956_08160	ENOG4108JQ7	(ABC) transporter
X956_08165	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
X956_08175	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
X956_08185	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
X956_08190	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
X956_08195	ENOG4107TK4	histidinol-phosphate phosphatase
X956_08205	ENOG4105EYH	Exonuclease
X956_08245	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
X956_08265	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
X956_08270	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
X956_08275	ENOG41087XN	oxidoreductase
X956_08280	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
X956_08285	ENOG4105D65	subunit l
X956_08300	ENOG4107QIZ	NADH dehydrogenase
X956_08310	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
X956_08315	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
X956_08320	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
X956_08330	ENOG4105P52	geranylgeranyl reductase
X956_08335	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
X956_08340	ENOG4105E4F	Isochorismate synthase
X956_08345	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
X956_08350	ENOG4105C0H	protease
X956_08360	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
X956_08365	ENOG4107TCW	O-succinylbenzoate synthase
X956_08370	ENOG4107SIQ	Naphthoate synthase
X956_08380	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
X956_08385	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
X956_08405	ENOG4108ZT1	Transcriptional regulator
X956_08410	ENOG4108RH7	phosphoglycerate mutase
X956_08435	ENOG4105CZN	Potassium uptake protein
X956_08440	ENOG4107ZYR	domain protein
X956_08445	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
X956_08455	ENOG4105CEN	a g-specific adenine glycosylase
X956_08470	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
X956_08475	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
X956_08480	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
X956_08485	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
X956_08495	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
X956_08500	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
X956_08505	ENOG4105EYF	MMPL domain protein
X956_08510	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
X956_08515	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
X956_08525	ENOG4105CRK	lysyL-tRNA synthetase
X956_08530	ENOG4105EYF	MMPL domain protein
X956_08545	ENOG4105CMT	Dihydroxyacetone kinase
X956_08550	ENOG4108UTZ	Dihydroxyacetone kinase
X956_08555	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
X956_08565	ENOG4105CNT	hydrolase family 2
X956_08585	ENOG4105ETE	Transcriptional regulator (LacI family
X956_08595	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
X956_08600	ENOG4105EUJ	GTP cyclohydrolase i
X956_08610	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X956_08620	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
X956_08625	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
X956_08630	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
X956_08645	ENOG4105F0N	pyrophosphate phospho-hydrolase
X956_08650	ENOG4105K4H	Nlp p60 protein
X956_08655	ENOG4105DWV	Homoserine O-trans-acetylase
X956_08660	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
X956_08670	ENOG4105CQB	FAD linked oxidase domain protein
X956_08675	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
X956_08700	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
X956_08705	ENOG4105CG3	alpha amylase, catalytic region
X956_08725	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
X956_08780	ENOG4105KT7	mgtC SapB transporter
X956_08785	ENOG4105C54	Major Facilitator superfamily
X956_08790	ENOG4105ETE	Transcriptional regulator (LacI family
X956_08805	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
X956_08825	ENOG41089UC	methyltransferase, type 11
X956_08830	ENOG4105ETE	Transcriptional regulator (LacI family
X956_08835	ENOG4105C2J	ABC transporter
X956_08840	ENOG4105CNN	ABC, transporter
X956_08845	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
X956_08850	ENOG4108RVA	ribokinase
X956_08855	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
X956_08860	ENOG4105CNT	hydrolase family 2
X956_08865	ENOG4105E2D	ec 3.2.1.52
X956_08875	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
X956_08885	ENOG4105C6Z	Gluconate
X956_08895	ENOG41060NJ	transcriptional regulator
X956_08905	ENOG4105CNT	hydrolase family 2
X956_08920	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
X956_08925	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
X956_08935	ENOG4105ETE	Transcriptional regulator (LacI family
X956_08945	ENOG4105DRS	transport system, permease
X956_08965	ENOG4105DFD	Na H antiporter
X956_08970	ENOG4105C87	Aminotransferase class I and II
X956_08975	ENOG4108HWW	ABC transporter
X956_08985	ENOG4105DFW	ABC transporter
X956_08995	ENOG4105C93	Xylose Isomerase
X956_09005	ENOG4107QKS	N-acylglucosamine 2-epimerase
X956_09020	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
X956_09035	ENOG4105E98	transcriptional regulator DeoR family
X956_09040	ENOG4105CJQ	hydrolase, family 31
X956_09070	ENOG4105CBG	Sulfatase
X956_09080	ENOG4105C54	Major Facilitator superfamily
X956_09085	ENOG4105C4X	radical SAM domain protein
X956_09090	ENOG4108VCT	Sulfite exporter TauE/SafE
X956_09095	ENOG4107YVI	ribose 5-phosphate isomerase
X956_09105	ENOG4105CMT	Dihydroxyacetone kinase
X956_09110	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
X956_09120	ENOG4105EF1	ribulokinase
X956_09130	ENOG4108ZYE	Transcriptional regulator
X956_09135	ENOG4105CMG	Carbohydrate kinase
X956_09140	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
X956_09150	ENOG4107RHR	regulatoR
X956_09155	ENOG4105EDR	glucose galactose transporter
X956_09165	ENOG4108RVA	ribokinase
X956_09170	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
X956_09175	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
X956_09185	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
X956_09190	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
X956_09200	ENOG4105CGH	5'-nucleotidase
X956_09225	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
X956_09230	ENOG4105CJ3	phosphate transporter
X956_09245	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
X956_09255	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
X956_09280	ENOG4105E0X	reductase
X956_09305	ENOG4105CJR	Integral membrane protein (MviN
X956_09310	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
X956_09325	ENOG4108YG4	
X956_09340	ENOG4105C94	Transporter
X956_09370	ENOG4105D82	Glutamate dehydrogenase
X956_09375	ENOG4105C8V	SAICAR synthetase
X956_09380	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
X956_09385	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
X956_09395	ENOG4107RCW	fructose-bisphosphate aldolase
X956_09410	ENOG4105M6F	mutator MutT protein
X956_09425	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
X956_09430	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
X956_09450	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
X956_09460	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
X956_09470	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
X956_09475	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
X956_09495	ENOG4105KNI	merR family transcriptional Regulator
X956_09500	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
X956_09505	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
X956_09510	ENOG4105CFG	Acts as a chaperone (By similarity)
X956_09515	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
X956_09520	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
X956_09535	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
X956_09550	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
X956_09560	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
X956_09570	ENOG4107QY8	reductase
X956_09575	ENOG4105QAX	Iron-sulfur
X956_09595	ENOG4105C4B	ABC transporter, permease
X956_09600	ENOG4105DKQ	ROK family
X956_09630	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
X956_09645	ENOG4108UCS	ABC, transporter
X956_09650	ENOG4105E0C	molybdate abc transporter
X956_09655	ENOG4105DP9	ABC transporter
X956_09680	ENOG4108JPZ	Monovalent cation H antiporter subunit D
X956_09685	ENOG4105MKQ	Monovalent cation H antiporter subunit C
X956_09690	ENOG4105D65	subunit l
X956_09695	ENOG4105DHP	deoxycytidine triphosphate deaminase
X956_09750	ENOG4105C6E	dna polymerase iii
X956_09755	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
X956_09760	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
X956_09765	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
X956_09775	ENOG4105VMP	Transcriptional regulator
X956_09860	ENOG4105BZ4	penicillin-binding protein
X956_09875	ENOG4108IUK	alpha amylase, catalytic
X956_09890	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
X956_09900	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
X956_09910	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
X956_09955	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
X956_09960	ENOG4105DPH	UPF0371 protein
X956_09965	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
X956_09975	ENOG4108Z6B	deaminase
X956_09980	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
X956_10025	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
X956_10030	ENOG4108KP7	hydrolase
X956_10075	ENOG4108RVA	ribokinase
X956_10080	ENOG4105D4B	ABC, transporter
X956_10085	ENOG4105CNN	ABC, transporter
X956_10115	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
X956_10160	ENOG4105NUN	Orthopoxvirus protein of unknown function (DUF830)
X956_10170	ENOG4105I1K	ABC transporter
X956_10175	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
X956_10190	ENOG4105ETE	Transcriptional regulator (LacI family
X956_10195	ENOG4108JJ8	(ABC) transporter
X956_10200	ENOG4105BZ1	(ABC) transporter
X956_10220	ENOG4105DQ5	transport system permease protein
X956_10230	ENOG4105E0A	ABC, transporter
X956_10240	ENOG4105DXX	methyltransferase
X956_10245	ENOG4105D7K	pfkb domain protein
X956_10250	ENOG4108UHU	Aldolase
X956_10255	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
X956_10260	ENOG4105DEI	Mannitol dehydrogenase
X956_10265	ENOG4108FUF	Transcriptional regulator, IclR family
X956_10270	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
X956_10285	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
X956_10290	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
X956_10295	ENOG4105DSB	aldose 1-epimerase
X956_10300	ENOG4105WH1	Two component transcriptional regulator luxr family
X956_10310	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
X956_10320	ENOG4108M15	ABC transporter
X956_10330	ENOG4108ZGX	Histidine kinase
X956_10335	ENOG4108S01	response regulator
X956_10340	ENOG4105CQ7	ATP-dependent helicase
X956_10350	ENOG4105H3G	oxidoreductase
X956_10370	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
X956_10375	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
X956_10395	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
X956_10405	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
X956_10410	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
X956_10415	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
X956_10430	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
X956_10440	ENOG4105HZM	Fha domain containing protein
X956_10445	ENOG4105IDI	abc transporter atp-binding protein
X956_10465	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
X956_10480	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
X956_10500	ENOG4105D9P	serine threonine protein kinase
X956_10510	ENOG4108RN7	integral membrane protein
X956_10515	ENOG4105ZJT	Cell division protein CrgA