locus-tag	class	description
HLG82_00030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG82_00060	COG0596	Alpha beta hydrolase
HLG82_00105	COG1205	dead DEAH box helicase
HLG82_00105	COG1111	helicase
HLG82_00110	COG3655	Transcriptional regulator
HLG82_00125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLG82_00125	COG1754	DNA topoisomerase type I activity
HLG82_00130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLG82_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG82_00245	COG2184	nucleotidyltransferase activity
HLG82_00265	COG1192	Involved in chromosome partitioning
HLG82_00275	COG4974	Belongs to the 'phage' integrase family
HLG82_00320	COG0588	phosphoglycerate mutase activity
HLG82_00330	COG0704	Plays a role in the regulation of phosphate uptake
HLG82_00340	COG0745	RESPONSE REGULATOR receiver
HLG82_00350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLG82_00355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLG82_00370	COG0215	cysteine-tRNA ligase activity
HLG82_00375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_00390	COG2233	PERMEase
HLG82_00430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLG82_00455	COG1175	transmembrane transport
HLG82_00460	COG1653	transport
HLG82_00475	COG3842	ATPase activity
HLG82_00500	COG1609	Transcriptional regulator
HLG82_00520	COG1175	transmembrane transport
HLG82_00525	COG0395	ABC-type sugar transport system, permease component
HLG82_00535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLG82_00550	COG0459	protein refolding
HLG82_00560	COG4221	oxidoreductase activity
HLG82_00570	COG2205	protein histidine kinase activity
HLG82_00575	COG0745	RESPONSE REGULATOR receiver
HLG82_00585	COG1842	Phage shock protein A
HLG82_00595	COG1278	Cold shock
HLG82_00605	COG1482	cell wall glycoprotein biosynthetic process
HLG82_00610	COG2252	PERMEase
HLG82_00620	COG1321	iron dependent repressor
HLG82_00685	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG82_00705	COG0596	Alpha beta hydrolase
HLG82_00720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLG82_00725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_00735	COG1120	ATPase activity
HLG82_00740	COG2188	Transcriptional regulator
HLG82_00745	COG0657	acetylesterase activity
HLG82_00750	COG0477	Major facilitator Superfamily
HLG82_00770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLG82_00775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLG82_00780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLG82_00785	COG0254	rRNA binding
HLG82_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLG82_00795	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_00800	COG3830	Belongs to the UPF0237 family
HLG82_00805	COG2848	UPF0210 protein
HLG82_00815	COG1511	domain protein
HLG82_00830	COG3711	transcriptional antiterminator
HLG82_00835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_00845	COG1051	belongs to the nudix hydrolase family
HLG82_00850	COG1131	(ABC) transporter
HLG82_00865	COG1263	PTS System
HLG82_00865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLG82_00875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG82_00895	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_00900	COG1556	Lactate utilization protein
HLG82_00910	COG0247	lactate metabolic process
HLG82_00915	COG1620	l-lactate permease
HLG82_00940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG82_00950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_00955	COG1120	ATPase activity
HLG82_00970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG82_00975	COG0667	Aldo Keto reductase
HLG82_00980	COG2813	Specifically methylates the guanine in position
HLG82_00995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_01005	COG2873	o-acetylhomoserine
HLG82_01025	COG1335	isochorismatase
HLG82_01035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG82_01040	COG0084	hydrolase, TatD family'
HLG82_01050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG82_01055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLG82_01060	COG0488	(ABC) transporter
HLG82_01070	COG1668	transmembrane transport
HLG82_01075	COG4152	abc transporter atp-binding protein
HLG82_01090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLG82_01100	COG1136	(ABC) transporter
HLG82_01105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLG82_01115	COG0193	aminoacyl-tRNA hydrolase activity
HLG82_01130	COG0148	phosphopyruvate hydratase activity
HLG82_01155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG82_01185	COG1131	(ABC) transporter
HLG82_01200	COG1012	belongs to the aldehyde dehydrogenase family
HLG82_01205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG82_01215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG82_01220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLG82_01225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLG82_01240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG82_01245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG82_01250	COG1722	exodeoxyribonuclease VII activity
HLG82_01255	COG1570	exodeoxyribonuclease VII activity
HLG82_01260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLG82_01265	COG1322	Protein conserved in bacteria
HLG82_01270	COG0012	GTP binding
HLG82_01340	COG4626	Terminase
HLG82_01340	COG1802	Transcriptional regulator
HLG82_01375	COG0740	serine-type endopeptidase activity
HLG82_01445	COG4824	toxin secretion phage lysis holin
HLG82_01465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_01515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG82_01515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG82_01540	COG0778	Nitroreductase
HLG82_01550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG82_01555	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_01575	COG1970	mechanosensitive ion channel activity
HLG82_01580	COG0242	peptide deformylase activity
HLG82_01590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLG82_01600	COG2116	formate transmembrane transporter activity
HLG82_01620	COG0425	Belongs to the sulfur carrier protein TusA family
HLG82_01625	COG2391	methyltransferase activity
HLG82_01630	COG2838	Isocitrate dehydrogenase
HLG82_01645	COG1362	aminopeptidase activity
HLG82_01655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG82_01660	COG0321	lipoyl(octanoyl) transferase activity
HLG82_01695	COG1132	(ABC) transporter
HLG82_01700	COG1132	(ABC) transporter
HLG82_01710	COG1217	gtp-binding protein TYPA
HLG82_01745	COG0424	maF-like protein
HLG82_01760	COG0745	RESPONSE REGULATOR receiver
HLG82_01765	COG0642	Histidine kinase
HLG82_01775	COG1316	TRANSCRIPTIONal
HLG82_01795	COG1088	dTDP-glucose 4,6-dehydratase activity
HLG82_01810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLG82_01820	COG0673	inositol 2-dehydrogenase activity
HLG82_01830	COG0438	transferase activity, transferring glycosyl groups
HLG82_01870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG82_01910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLG82_01925	COG0483	inositol monophosphate 1-phosphatase activity
HLG82_01970	COG0714	Associated with various cellular activities
HLG82_01990	COG0745	RESPONSE REGULATOR receiver
HLG82_01995	COG5002	protein histidine kinase activity
HLG82_02000	COG5401	PFAM Sporulation and spore germination
HLG82_02010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLG82_02020	COG1666	GTP binding
HLG82_02040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLG82_02045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLG82_02060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLG82_02070	COG0436	Aminotransferase
HLG82_02090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLG82_02095	COG0081	regulation of translation
HLG82_02100	COG0572	uridine kinase
HLG82_02105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLG82_02110	COG0222	ribosome binding
HLG82_02115	COG0085	RNA polymerase activity
HLG82_02120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLG82_02125	COG0833	amino acid
HLG82_02130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLG82_02135	COG0049	tRNA binding
HLG82_02140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLG82_02145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLG82_02155	COG0051	transcription antitermination factor activity, RNA binding
HLG82_02160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLG82_02165	COG0088	Forms part of the polypeptide exit tunnel
HLG82_02170	COG0089	rRNA binding
HLG82_02175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLG82_02180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLG82_02185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLG82_02190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLG82_02195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLG82_02210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLG82_02215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLG82_02220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLG82_02225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLG82_02230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLG82_02235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLG82_02245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLG82_02250	COG1841	ribosomal large subunit assembly
HLG82_02255	COG0200	Binds to the 23S rRNA
HLG82_02260	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_02275	COG0563	adenylate kinase activity
HLG82_02280	COG0024	Methionine aminopeptidase
HLG82_02285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLG82_02290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLG82_02295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLG82_02305	COG0202	RNA polymerase activity
HLG82_02310	COG0203	ribosomal protein L17
HLG82_02315	COG0789	Transcriptional regulator
HLG82_02325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG82_02335	COG0640	Transcriptional regulator
HLG82_02340	COG1126	abc transporter atp-binding protein
HLG82_02345	COG0765	amino acid transport
HLG82_02355	COG1940	carbohydrate kinase activity
HLG82_02360	COG0101	tRNA pseudouridine synthase activity
HLG82_02375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLG82_02380	COG1122	ATPase activity
HLG82_02385	COG4720	Psort location CytoplasmicMembrane, score
HLG82_02395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLG82_02400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLG82_02410	COG1072	(Pantothenic acid kinase))
HLG82_02415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLG82_02425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG82_02430	COG0802	atpase or kinase
HLG82_02455	COG1053	succinate dehydrogenase
HLG82_02460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG82_02470	COG0733	neurotransmitter:sodium symporter activity
HLG82_02475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLG82_02490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLG82_02500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLG82_02505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLG82_02510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLG82_02515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLG82_02520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLG82_02525	COG0151	Belongs to the GarS family
HLG82_02530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLG82_02550	COG0516	GMP reductase activity
HLG82_02555	COG0114	fumarate hydratase activity
HLG82_02565	COG1136	(ABC) transporter
HLG82_02580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG82_02585	COG0280	phosphate acetyltransferase
HLG82_02585	COG0857	belongs to the CobB CobQ family
HLG82_02590	COG0564	pseudouridine synthase activity
HLG82_02610	COG5646	InterPro IPR014922
HLG82_02620	COG2755	lipolytic protein G-D-S-L family
HLG82_02620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLG82_02625	COG0045	succinate-CoA ligase (ADP-forming) activity
HLG82_02645	COG0138	bifunctional purine biosynthesis protein purh
HLG82_02655	COG0205	6-phosphofructokinase activity
HLG82_02660	COG0166	Belongs to the GPI family
HLG82_02670	COG0039	L-malate dehydrogenase activity
HLG82_02680	COG0110	maltose O-acetyltransferase activity
HLG82_02710	COG2030	dehydratase
HLG82_02715	COG2271	Major facilitator Superfamily
HLG82_02740	COG0644	oxidoreductase
HLG82_02760	COG4770	biotin carboxylase activity
HLG82_02765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG82_02770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLG82_02775	COG0736	holo-[acyl-carrier-protein] synthase activity
HLG82_02780	COG1268	BioY protein
HLG82_02790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLG82_02795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLG82_02815	COG1744	ABC transporter substrate-binding protein PnrA-like
HLG82_02820	COG3845	ABC transporter
HLG82_02825	COG4603	Belongs to the binding-protein-dependent transport system permease family
HLG82_02830	COG1079	Belongs to the binding-protein-dependent transport system permease family
HLG82_02850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLG82_02855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG82_02865	COG1611	Belongs to the LOG family
HLG82_02890	COG2239	Acts as a magnesium transporter
HLG82_02895	COG0006	proline dipeptidase activity
HLG82_02905	COG2095	MarC family integral membrane protein
HLG82_02910	COG0513	Belongs to the DEAD box helicase family
HLG82_02925	COG0210	DNA helicase
HLG82_02985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLG82_02990	COG2884	Cell division ATP-binding protein ftsE
HLG82_02995	COG2177	Part of the ABC transporter FtsEX involved in
HLG82_03000	COG0739	heme binding
HLG82_03005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLG82_03015	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLG82_03055	COG0351	phosphomethylpyrimidine kinase
HLG82_03055	COG0352	thiamine-phosphate diphosphorylase activity
HLG82_03055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG82_03060	COG0477	Major facilitator Superfamily
HLG82_03065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HLG82_03070	COG0352	thiamine-phosphate diphosphorylase activity
HLG82_03085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_03125	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_03180	COG0778	Nitroreductase
HLG82_03200	COG0737	Belongs to the 5'-nucleotidase family
HLG82_03210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLG82_03225	COG0569	domain protein
HLG82_03225	COG2985	domain, Protein
HLG82_03235	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_03255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLG82_03265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG82_03270	COG1234	tRNA 3'-trailer cleavage
HLG82_03275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLG82_03280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLG82_03305	COG1022	Amp-dependent synthetase and ligase
HLG82_03310	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG82_03335	COG1609	Transcriptional regulator
HLG82_03370	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_03375	COG0339	signal peptide processing
HLG82_03380	COG4975	Glucose uptake
HLG82_03395	COG0438	transferase activity, transferring glycosyl groups
HLG82_03405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLG82_03410	COG0066	3-isopropylmalate dehydratase activity
HLG82_03425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLG82_03435	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLG82_03455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLG82_03460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLG82_03470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLG82_03485	COG0571	ribonuclease III activity
HLG82_03490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLG82_03510	COG1132	(ABC) transporter
HLG82_03515	COG1132	(ABC) transporter
HLG82_03530	COG4988	ABC transporter
HLG82_03535	COG1294	oxidase, subunit
HLG82_03540	COG1271	oxidase subunit
HLG82_03545	COG1530	ribonuclease E activity
HLG82_03550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLG82_03555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLG82_03560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLG82_03570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG82_03575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLG82_03585	COG0799	negative regulation of ribosome biogenesis
HLG82_03590	COG0406	alpha-ribazole phosphatase activity
HLG82_03605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_03640	COG1136	(ABC) transporter
HLG82_03705	COG0133	tryptophan synthase activity
HLG82_03735	COG3250	beta-galactosidase activity
HLG82_03745	COG1609	Transcriptional regulator
HLG82_03770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG82_03775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLG82_03780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLG82_03785	COG0826	peptidase U32
HLG82_03790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG82_03800	COG1113	amino acid transport
HLG82_03810	COG2011	ABC-type metal ion transport system permease component
HLG82_03815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_03820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG82_03820	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG82_03830	COG1113	amino acid transport
HLG82_03845	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_03855	COG0671	phosphoesterase, PA-phosphatase related
HLG82_03875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_03880	COG1121	(ABC) transporter
HLG82_03910	COG1435	thymidine kinase activity
HLG82_03915	COG1321	iron dependent repressor
HLG82_03915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_03920	COG0813	purine-nucleoside phosphorylase activity
HLG82_03945	COG0495	leucyl-tRNA aminoacylation
HLG82_03955	COG0433	COG0433 Predicted ATPase
HLG82_03960	COG1596	polysaccharide export
HLG82_03960	COG1555	photosystem II stabilization
HLG82_03975	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HLG82_03980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HLG82_03985	COG0268	Binds directly to 16S ribosomal RNA
HLG82_03990	COG3237	CsbD-like
HLG82_04010	COG0481	GTPase activity
HLG82_04015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLG82_04035	COG1420	regulation of RNA biosynthetic process
HLG82_04040	COG0484	heat shock protein binding
HLG82_04055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLG82_04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG82_04100	COG1381	Involved in DNA repair and RecF pathway recombination
HLG82_04105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG82_04110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLG82_04120	COG0131	Imidazoleglycerol-phosphate dehydratase
HLG82_04130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLG82_04135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLG82_04145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLG82_04150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLG82_04165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_04170	COG1902	pentaerythritol trinitrate reductase activity
HLG82_04190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG82_04195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLG82_04205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLG82_04210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLG82_04215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLG82_04220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG82_04230	COG0137	argininosuccinate synthase activity
HLG82_04240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLG82_04245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG82_04250	COG0165	Argininosuccinate lyase
HLG82_04255	COG1476	TRANSCRIPTIONal
HLG82_04270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLG82_04280	COG1121	(ABC) transporter
HLG82_04285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_04290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_04315	COG0647	UMP catabolic process
HLG82_04330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLG82_04335	COG0497	DNA recombination
HLG82_04355	COG0728	peptidoglycan biosynthetic process
HLG82_04375	COG0719	Fe-S assembly protein
HLG82_04400	COG2151	metal-sulfur cluster biosynthetic enzyme
HLG82_04405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLG82_04415	COG0488	(ABC) transporter
HLG82_04430	COG3830	Belongs to the UPF0237 family
HLG82_04430	COG0560	Phosphoserine phosphatase
HLG82_04440	COG0297	glycogen (starch) synthase activity
HLG82_04445	COG1119	ATPase activity
HLG82_04460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_04475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLG82_04480	COG1881	PFAM PEBP family protein
HLG82_04495	COG0587	DNA-directed DNA polymerase activity
HLG82_04515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLG82_04520	COG0519	Catalyzes the synthesis of GMP from XMP
HLG82_04525	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HLG82_04530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_04545	COG1968	undecaprenyl-diphosphatase activity
HLG82_04550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG82_04565	COG1222	aaa ATPase
HLG82_04570	COG4122	O-methyltransferase activity
HLG82_04580	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HLG82_04595	COG0107	imidazoleglycerol-phosphate synthase activity
HLG82_04605	COG0134	indole-3-glycerol-phosphate synthase activity
HLG82_04610	COG0133	tryptophan synthase activity
HLG82_04620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLG82_04625	COG0469	pyruvate kinase activity
HLG82_04650	COG2226	methyltransferase
HLG82_04655	COG0539	negative regulation of cytoplasmic translation
HLG82_04660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLG82_04665	COG0237	dephospho-CoA kinase activity
HLG82_04670	COG0556	nucleotide-excision repair
HLG82_04695	COG0322	excinuclease ABC activity
HLG82_04710	COG1481	regulation of sporulation
HLG82_04715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLG82_04720	COG0126	phosphoglycerate kinase activity
HLG82_04725	COG0149	triose-phosphate isomerase activity
HLG82_04730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLG82_04745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG82_04770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLG82_04780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLG82_04785	COG1160	GTP binding
HLG82_04790	COG0205	6-phosphofructokinase activity
HLG82_04800	COG1834	amidinotransferase
HLG82_04810	COG1716	ATPase activity
HLG82_04835	COG1216	Glycosyl transferase, family 2
HLG82_04875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLG82_04880	COG0140	phosphoribosyl-ATP diphosphatase activity
HLG82_04885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG82_04890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG82_04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLG82_04905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLG82_04915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLG82_04925	COG1758	RNA polymerase activity
HLG82_04930	COG0194	GDP metabolic process
HLG82_04940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLG82_04945	COG0505	Belongs to the CarA family
HLG82_04950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLG82_04955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLG82_04960	COG2217	Heavy metal translocating P-type atpase
HLG82_04975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLG82_04995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLG82_05000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLG82_05010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLG82_05020	COG2409	Drug exporters of the RND superfamily
HLG82_05035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLG82_05040	COG2814	Major facilitator Superfamily
HLG82_05055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLG82_05060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLG82_05065	COG0124	histidyl-tRNA synthetase
HLG82_05075	COG1196	nuclear chromosome segregation
HLG82_05085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG82_05090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLG82_05095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG82_05100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG82_05110	COG2255	four-way junction helicase activity
HLG82_05115	COG0632	four-way junction helicase activity
HLG82_05120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HLG82_05125	COG0217	transcriptional regulatory protein
HLG82_05145	COG0438	transferase activity, transferring glycosyl groups
HLG82_05155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLG82_05160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLG82_05165	COG1760	l-serine dehydratase
HLG82_05170	COG2197	response regulator
HLG82_05230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HLG82_05235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLG82_05240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG82_05255	COG0569	domain protein
HLG82_05300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLG82_05315	COG0187	DNA topoisomerase II activity
HLG82_05330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLG82_05345	COG0142	geranyltranstransferase activity
HLG82_05360	COG0515	serine threonine protein kinase
HLG82_05360	COG2815	serine threonine protein kinase
HLG82_05365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HLG82_05370	COG0205	6-phosphofructokinase activity
HLG82_05420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_05435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLG82_05445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG82_05450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG82_05470	COG0174	glutamine synthetase
HLG82_05500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLG82_05505	COG0174	glutamine synthetase
HLG82_05520	COG1940	carbohydrate kinase activity
HLG82_05540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLG82_05545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLG82_05550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLG82_05575	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HLG82_05580	COG0477	Major facilitator Superfamily
HLG82_05600	COG0009	L-threonylcarbamoyladenylate synthase
HLG82_05620	COG1090	epimerase
HLG82_05660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLG82_05665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_05695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG82_05700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG82_05705	COG0805	protein transport
HLG82_05715	COG0358	DNA primase activity
HLG82_05730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG82_05740	COG0423	glycine-tRNA ligase activity
HLG82_05750	COG1121	(ABC) transporter
HLG82_05755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_05770	COG2501	S4 domain
HLG82_05775	COG0587	DNA-directed DNA polymerase activity
HLG82_05790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLG82_05805	COG1799	cell septum assembly
HLG82_05810	COG1496	oxidoreductase activity
HLG82_05815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLG82_05825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG82_05830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLG82_05840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLG82_05845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLG82_05850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLG82_05855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG82_05860	COG0768	penicillin binding
HLG82_05870	COG0275	rRNA processing
HLG82_05875	COG2001	Belongs to the MraZ family
HLG82_05885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLG82_05910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG82_05915	COG0318	PFAM AMP-dependent synthetase and ligase
HLG82_05920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLG82_05940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLG82_05945	COG2813	Specifically methylates the guanine in position
HLG82_05950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLG82_05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLG82_05960	COG2137	regulation of response to DNA damage stimulus
HLG82_05965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLG82_05975	COG1396	sequence-specific DNA binding
HLG82_05980	COG1546	Belongs to the CinA family
HLG82_05980	COG1058	Belongs to the CinA family
HLG82_05995	COG1674	ftsk spoiiie
HLG82_06000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLG82_06005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG82_06020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLG82_06025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLG82_06030	COG0612	Peptidase, M16
HLG82_06040	COG1185	polyribonucleotide nucleotidyltransferase activity
HLG82_06070	COG2801	Transposase and inactivated derivatives
HLG82_06105	COG1131	(ABC) transporter
HLG82_06135	COG3842	ATPase activity
HLG82_06145	COG2271	Major facilitator Superfamily
HLG82_06155	COG5002	protein histidine kinase activity
HLG82_06160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLG82_06165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLG82_06170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLG82_06185	COG0779	Required for maturation of 30S ribosomal subunits
HLG82_06195	COG0442	prolyl-tRNA aminoacylation
HLG82_06205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLG82_06210	COG0750	zinc metalloprotease
HLG82_06215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLG82_06225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLG82_06235	COG0233	cytoplasmic translational termination
HLG82_06240	COG0528	UMP kinase activity
HLG82_06255	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_06265	COG0644	oxidoreductase
HLG82_06270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLG82_06280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLG82_06285	COG0052	Belongs to the universal ribosomal protein uS2 family
HLG82_06290	COG2860	membrane
HLG82_06300	COG4974	Belongs to the 'phage' integrase family
HLG82_06315	COG0792	nuclease activity
HLG82_06325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLG82_06330	COG0681	Belongs to the peptidase S26 family
HLG82_06335	COG0335	large ribosomal subunit rRNA binding
HLG82_06345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLG82_06350	COG1837	Belongs to the UPF0109 family
HLG82_06360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLG82_06380	COG1473	amidohydrolase
HLG82_06385	COG3069	C4-dicarboxylate transmembrane transporter activity
HLG82_06400	COG0105	UTP biosynthetic process
HLG82_06410	COG0285	dihydrofolate synthase activity
HLG82_06415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLG82_06430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLG82_06450	COG0287	Prephenate dehydrogenase
HLG82_06450	COG1605	Chorismate mutase
HLG82_06455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLG82_06460	COG0740	serine-type endopeptidase activity
HLG82_06465	COG0740	serine-type endopeptidase activity
HLG82_06470	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLG82_06475	COG0667	Aldo Keto reductase
HLG82_06500	COG0393	Putative heavy-metal-binding
HLG82_06530	COG1739	Uncharacterized protein family UPF0029
HLG82_06540	COG1045	serine acetyltransferase
HLG82_06550	COG3590	peptidase
HLG82_06555	COG2354	Protein conserved in bacteria
HLG82_06570	COG2818	Glycosylase
HLG82_06575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLG82_06575	COG2190	(PTS) system
HLG82_06575	COG1263	PTS System
HLG82_06605	COG1162	GTPase activity
HLG82_06615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLG82_06640	COG0463	Glycosyl transferase, family 2
HLG82_06640	COG1216	Glycosyl transferase, family 2
HLG82_06645	COG2244	polysaccharide biosynthetic process
HLG82_06670	COG1442	glycosyl transferase family 8
HLG82_06670	COG1216	Glycosyl transferase, family 2
HLG82_06675	COG3475	LICD family
HLG82_06680	COG4750	Nucleotidyl transferase
HLG82_06715	COG1882	Formate acetyltransferase
HLG82_06720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLG82_06725	COG0473	3-isopropylmalate dehydrogenase activity
HLG82_06745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLG82_06750	COG0440	acetolactate synthase activity
HLG82_06760	COG0569	domain protein
HLG82_06760	COG2985	domain, Protein
HLG82_06765	COG0129	dihydroxy-acid dehydratase activity
HLG82_06825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG82_06830	COG0154	amidase activity
HLG82_06835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG82_06840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG82_06850	COG1404	Belongs to the peptidase S8 family
HLG82_06855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLG82_06860	COG2135	peptidase activity
HLG82_06865	COG4585	Histidine kinase
HLG82_06875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_06890	COG4989	oxidoreductase activity
HLG82_06905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLG82_06910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLG82_06925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG82_06930	COG1053	succinate dehydrogenase
HLG82_06940	COG0387	Pfam Sodium calcium exchanger
HLG82_06950	COG1131	(ABC) transporter
HLG82_06955	COG1725	Transcriptional regulator
HLG82_06965	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_06990	COG0366	Alpha amylase catalytic
HLG82_06990	COG1470	cell adhesion involved in biofilm formation
HLG82_06995	COG1615	UPF0182 protein
HLG82_07005	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLG82_07035	COG0180	Tryptophanyl-tRNA synthetase
HLG82_07040	COG0058	SHG alpha-glucan phosphorylase activity
HLG82_07050	COG0366	Alpha amylase catalytic
HLG82_07065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLG82_07080	COG3833	ABC-type maltose transport systems, permease component
HLG82_07085	COG1175	transmembrane transport
HLG82_07100	COG0366	Alpha amylase catalytic
HLG82_07130	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HLG82_07145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLG82_07150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLG82_07155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLG82_07160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLG82_07165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLG82_07170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLG82_07175	COG0356	it plays a direct role in the translocation of protons across the membrane
HLG82_07195	COG2890	protein-(glutamine-N5) methyltransferase activity
HLG82_07200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLG82_07215	COG0083	homoserine kinase activity
HLG82_07220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLG82_07225	COG0460	homoserine dehydrogenase
HLG82_07230	COG0019	diaminopimelate decarboxylase activity
HLG82_07235	COG0018	arginyl-trna synthetase
HLG82_07280	COG4942	peptidase
HLG82_07280	COG1388	LysM domain
HLG82_07290	COG1253	flavin adenine dinucleotide binding
HLG82_07295	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG82_07295	COG0567	Dehydrogenase, E1 component
HLG82_07305	COG1388	LysM domain
HLG82_07305	COG0791	NLP P60 protein
HLG82_07305	COG3103	Sh3 type 3 domain protein
HLG82_07315	COG1595	DNA-templated transcription, initiation
HLG82_07320	COG0363	glucosamine-6-phosphate deaminase activity
HLG82_07325	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLG82_07330	COG1940	carbohydrate kinase activity
HLG82_07330	COG1846	Transcriptional regulator
HLG82_07335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG82_07340	COG4608	Belongs to the ABC transporter superfamily
HLG82_07345	COG0444	Belongs to the ABC transporter superfamily
HLG82_07350	COG0601	transmembrane transport
HLG82_07355	COG0747	negative chemotaxis
HLG82_07365	COG0657	acetylesterase activity
HLG82_07380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLG82_07390	COG0483	inositol monophosphate 1-phosphatase activity
HLG82_07395	COG0420	3'-5' exonuclease activity
HLG82_07400	COG0419	ATPase involved in DNA repair
HLG82_07440	COG0653	protein targeting
HLG82_07445	COG0142	geranyltranstransferase activity
HLG82_07450	COG1007	ATP synthesis coupled electron transport
HLG82_07460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG82_07465	COG0713	ATP synthesis coupled electron transport
HLG82_07475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_07480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HLG82_07485	COG1034	ATP synthesis coupled electron transport
HLG82_07490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLG82_07500	COG0649	NAD binding
HLG82_07505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_07510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_07520	COG0644	oxidoreductase
HLG82_07525	COG2226	methyltransferase
HLG82_07540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLG82_07545	COG4948	Mandelate Racemase Muconate Lactonizing
HLG82_07550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLG82_07555	COG1653	transport
HLG82_07560	COG1177	transmembrane transport
HLG82_07565	COG0395	ABC-type sugar transport system, permease component
HLG82_07590	COG0406	alpha-ribazole phosphatase activity
HLG82_07610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG82_07615	COG0569	domain protein
HLG82_07620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLG82_07630	COG1194	a g-specific adenine glycosylase
HLG82_07640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLG82_07645	COG2390	Transcriptional regulator
HLG82_07650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLG82_07660	COG0247	lactate metabolic process
HLG82_07675	COG1131	(ABC) transporter
HLG82_07690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLG82_07695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLG82_07700	COG2409	Drug exporters of the RND superfamily
HLG82_07705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLG82_07715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HLG82_07720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLG82_07730	COG2376	Dihydroxyacetone kinase
HLG82_07735	COG1461	Dihydroxyacetone kinase
HLG82_07740	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG82_07740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_07745	COG3250	beta-galactosidase activity
HLG82_07765	COG1609	Transcriptional regulator
HLG82_07785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLG82_07790	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLG82_07795	COG0302	gtp cyclohydrolase
HLG82_07800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG82_07805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HLG82_07810	COG0037	tRNA processing
HLG82_07825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLG82_07830	COG0791	NLP P60 protein
HLG82_07835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG82_07840	COG2267	carboxylic ester hydrolase activity
HLG82_07850	COG0277	FAD linked oxidase domain protein
HLG82_07850	COG0247	lactate metabolic process
HLG82_07880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_07880	COG0574	Belongs to the PEP-utilizing enzyme family
HLG82_07885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG82_07910	COG0464	growth
HLG82_07930	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLG82_07985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLG82_07985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLG82_07990	COG3617	BRO family, N-terminal domain
HLG82_08030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLG82_08060	COG1802	Transcriptional regulator
HLG82_08060	COG4626	Terminase
HLG82_08065	COG4695	Portal protein
HLG82_08070	COG0740	serine-type endopeptidase activity
HLG82_08140	COG4824	toxin secretion phage lysis holin
HLG82_08155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_08180	COG1715	Restriction endonuclease
HLG82_08190	COG3177	Filamentation induced by cAMP protein fic
HLG82_08205	COG1252	NADH dehydrogenase
HLG82_08210	COG3119	arylsulfatase activity
HLG82_08215	COG1609	Transcriptional regulator
HLG82_08220	COG2271	Major facilitator Superfamily
HLG82_08225	COG0641	radical SAM
HLG82_08230	COG0730	response to heat
HLG82_08255	COG2226	methyltransferase
HLG82_08260	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_08270	COG3250	beta-galactosidase activity
HLG82_08290	COG0698	ribose 5-phosphate isomerase
HLG82_08295	COG1063	alcohol dehydrogenase
HLG82_08300	COG2376	Dihydroxyacetone kinase
HLG82_08325	COG1070	Carbohydrate kinase
HLG82_08330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLG82_08340	COG2390	Transcriptional regulator
HLG82_08345	COG0738	Major facilitator superfamily
HLG82_08365	COG1490	D-aminoacyl-tRNA deacylase activity
HLG82_08385	COG3485	protocatechuate 3,4-dioxygenase
HLG82_08395	COG1115	amino acid carrier protein
HLG82_08405	COG0306	phosphate transporter
HLG82_08410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG82_08425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLG82_08430	COG0406	alpha-ribazole phosphatase activity
HLG82_08430	COG0494	nUDIX hydrolase
HLG82_08435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLG82_08460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG82_08490	COG2348	transferase activity, transferring amino-acyl groups
HLG82_08495	COG2348	transferase activity, transferring amino-acyl groups
HLG82_08510	COG0039	L-malate dehydrogenase activity
HLG82_08545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG82_08570	COG0557	exoribonuclease II activity
HLG82_08580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG82_08595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLG82_08600	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HLG82_08605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLG82_08615	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_08620	COG0191	fructose-bisphosphate aldolase activity
HLG82_08640	COG0494	nUDIX hydrolase
HLG82_08695	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_08700	COG3949	Membrane
HLG82_08705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG82_08720	COG1506	peptidase
HLG82_08720	COG0823	Involved in the tonB-independent uptake of proteins
HLG82_08725	COG0584	glycerophosphoryl diester phosphodiesterase
HLG82_08735	COG0789	Transcriptional regulator
HLG82_08740	COG0484	heat shock protein binding
HLG82_08745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLG82_08750	COG0443	Heat shock 70 kDa protein
HLG82_08755	COG0167	dihydroorotate dehydrogenase activity
HLG82_08770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLG82_08775	COG0284	orotidine-5'-phosphate decarboxylase activity
HLG82_08780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLG82_08785	COG0540	Belongs to the ATCase OTCase family
HLG82_08790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLG82_08805	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG82_08810	COG1937	Protein conserved in bacteria
HLG82_08815	COG0243	molybdopterin cofactor binding
HLG82_08820	COG0437	4 iron, 4 sulfur cluster binding
HLG82_08840	COG1505	serine-type exopeptidase activity
HLG82_08850	COG0390	transport system, permease component
HLG82_08855	COG1940	carbohydrate kinase activity
HLG82_08895	COG0662	Cupin 2, conserved barrel domain protein
HLG82_08920	COG3842	ATPase activity
HLG82_08930	COG4143	(ABC) transporter
HLG82_08955	COG0651	ATP synthesis coupled electron transport
HLG82_08960	COG1006	Multisubunit Na H antiporter MnhC subunit
HLG82_08965	COG2111	Na H antiporter
HLG82_08965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG82_08970	COG0717	Belongs to the dCTP deaminase family
HLG82_08985	COG3177	Filamentation induced by cAMP protein fic
HLG82_08995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLG82_09005	COG3345	alpha-galactosidase
HLG82_09030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLG82_09035	COG0667	Aldo Keto reductase
HLG82_09055	COG0710	3-dehydroquinate dehydratase activity
HLG82_09085	COG0714	Associated with various cellular activities
HLG82_09100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG82_09105	COG1950	PFAM Membrane protein of
HLG82_09110	COG3001	Fructosamine kinase
HLG82_09115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLG82_09120	COG0586	Pfam SNARE associated Golgi protein
HLG82_09135	COG2217	Heavy metal translocating P-type atpase
HLG82_09150	COG4604	ABC transporter, ATP-binding protein
HLG82_09160	COG2814	Major facilitator Superfamily
HLG82_09170	COG0673	inositol 2-dehydrogenase activity
HLG82_09175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG82_09195	COG3718	enzyme involved in inositol metabolism
HLG82_09200	COG3962	Belongs to the TPP enzyme family
HLG82_09210	COG4604	ABC transporter, ATP-binding protein
HLG82_09215	COG4605	iron ion homeostasis
HLG82_09230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLG82_09250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG82_09255	COG1904	glucuronate isomerase
HLG82_09270	COG3971	2-oxopent-4-enoate hydratase activity
HLG82_09280	COG1802	Transcriptional regulator
HLG82_09285	COG0477	Major facilitator Superfamily
HLG82_09295	COG1012	belongs to the aldehyde dehydrogenase family
HLG82_09300	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG82_09320	COG3142	Participates in the control of copper homeostasis
HLG82_09335	COG1940	carbohydrate kinase activity
HLG82_09345	COG0601	transmembrane transport
HLG82_09350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG82_09360	COG1940	carbohydrate kinase activity
HLG82_09365	COG1846	Transcriptional regulator
HLG82_09365	COG1940	carbohydrate kinase activity
HLG82_09375	COG1175	transmembrane transport
HLG82_09405	COG1486	melibiose metabolic process
HLG82_09410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLG82_09410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLG82_09415	COG1879	ABC-type sugar transport system periplasmic component
HLG82_09420	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLG82_09430	COG2188	Transcriptional regulator
HLG82_09455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLG82_09470	COG0395	ABC-type sugar transport system, permease component
HLG82_09475	COG1175	transmembrane transport
HLG82_09490	COG1609	Transcriptional regulator
HLG82_09495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG82_09500	COG0800	Aldolase
HLG82_09505	COG1312	Catalyzes the dehydration of D-mannonate
HLG82_09510	COG0246	Mannitol dehydrogenase
HLG82_09515	COG1414	Transcriptional regulator
HLG82_09530	COG1328	CTP reductase activity
HLG82_09545	COG2197	response regulator
HLG82_09555	COG1136	(ABC) transporter
HLG82_09565	COG2197	response regulator
HLG82_09570	COG1643	Atp-dependent helicase
HLG82_09590	COG1175	transmembrane transport
HLG82_09595	COG0395	ABC-type sugar transport system, permease component
HLG82_09600	COG1653	transport
HLG82_09630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG82_09640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG82_09645	COG3253	May function as heme-dependent peroxidase
HLG82_09650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLG82_09655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG82_09660	COG1780	Probably involved in ribonucleotide reductase function
HLG82_09680	COG1854	S-ribosylhomocysteine lyase activity
HLG82_09685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG82_09720	COG0842	Transport permease protein
HLG82_09720	COG1716	ATPase activity
HLG82_09720	COG1131	(ABC) transporter
HLG82_09740	COG0768	penicillin binding
HLG82_09755	COG3764	Sortase (surface protein transpeptidase)
HLG82_09810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLG82_09815	COG0187	DNA topoisomerase II activity
HLG82_09820	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HLG82_09825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLG82_09835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLG82_09840	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLG82_09845	COG0594	ribonuclease P activity
HLG82_09850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLG82_09855	COG0706	membrane insertase activity
HLG82_09865	COG0357	Ribosomal RNA small subunit methyltransferase G
HLG82_09880	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLG82_09885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG82_09890	COG0492	ferredoxin-NADP+ reductase activity
HLG82_09920	COG0628	permease
HLG82_09925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG82_09930	COG0360	Binds together with S18 to 16S ribosomal RNA
HLG82_09940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLG82_09945	COG0359	binds to the 23S rRNA
HLG82_09965	COG0305	Participates in initiation and elongation during chromosome replication
HLG82_09975	COG0084	hydrolase, TatD family'
HLG82_09980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLG82_09995	COG0351	phosphomethylpyrimidine kinase
HLG82_10000	COG0656	L-ascorbic acid biosynthetic process
HLG82_10040	COG1428	Deoxynucleoside kinase
HLG82_10050	COG0343	queuine tRNA-ribosyltransferase activity
HLG82_10055	COG2205	protein histidine kinase activity
HLG82_10060	COG0745	RESPONSE REGULATOR receiver
HLG82_10075	COG1136	(ABC) transporter
HLG82_10075	COG0577	efflux transmembrane transporter activity
HLG82_10080	COG1136	(ABC) transporter
HLG82_10080	COG0577	efflux transmembrane transporter activity
HLG82_10100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG82_10105	COG0569	domain protein
HLG82_10115	COG1643	Atp-dependent helicase
HLG82_10130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLG82_10180	COG1518	maintenance of DNA repeat elements
HLG82_10190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG82_10220	COG0471	metal ion transport
HLG82_10245	COG0561	phosphatase activity
HLG82_10250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLG82_10260	COG0077	Prephenate dehydratase
HLG82_10270	COG1215	transferase activity, transferring glycosyl groups
HLG82_10285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLG82_10290	COG0590	tRNA wobble adenosine to inosine editing
HLG82_10300	COG1114	Component of the transport system for branched-chain amino acids
HLG82_10305	COG4868	Belongs to the UPF0371 family
HLG82_10310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLG82_10365	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG82_10375	COG0315	cyclic pyranopterin monophosphate synthase activity
HLG82_10385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate