locus-tag	class	description
INS88_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INS88_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INS88_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
INS88_00025	COG0187	DNA topoisomerase II activity
INS88_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS88_00085	COG3764	Sortase (surface protein transpeptidase)
INS88_00100	COG0768	penicillin binding
INS88_00120	COG0842	Transport permease protein
INS88_00120	COG1131	(ABC) transporter
INS88_00120	COG1716	ATPase activity
INS88_00155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INS88_00160	COG1854	S-ribosylhomocysteine lyase activity
INS88_00175	COG1780	Probably involved in ribonucleotide reductase function
INS88_00180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS88_00185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS88_00190	COG3253	May function as heme-dependent peroxidase
INS88_00195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INS88_00205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS88_00235	COG1653	transport
INS88_00240	COG0395	ABC-type sugar transport system, permease component
INS88_00245	COG1175	transmembrane transport
INS88_00265	COG1643	Atp-dependent helicase
INS88_00270	COG2197	response regulator
INS88_00280	COG1136	(ABC) transporter
INS88_00290	COG2197	response regulator
INS88_00305	COG1328	CTP reductase activity
INS88_00320	COG1414	Transcriptional regulator
INS88_00325	COG0246	Mannitol dehydrogenase
INS88_00330	COG1312	Catalyzes the dehydration of D-mannonate
INS88_00335	COG0800	Aldolase
INS88_00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS88_00345	COG1609	Transcriptional regulator
INS88_00360	COG1175	transmembrane transport
INS88_00365	COG0395	ABC-type sugar transport system, permease component
INS88_00375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INS88_00400	COG2188	Transcriptional regulator
INS88_00410	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS88_00415	COG1879	ABC-type sugar transport system periplasmic component
INS88_00420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INS88_00420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INS88_00425	COG1486	melibiose metabolic process
INS88_00455	COG1175	transmembrane transport
INS88_00465	COG1846	Transcriptional regulator
INS88_00465	COG1940	carbohydrate kinase activity
INS88_00470	COG1940	carbohydrate kinase activity
INS88_00480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INS88_00485	COG0601	transmembrane transport
INS88_00495	COG1940	carbohydrate kinase activity
INS88_00510	COG3142	Participates in the control of copper homeostasis
INS88_00530	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS88_00535	COG1012	belongs to the aldehyde dehydrogenase family
INS88_00545	COG0477	Major facilitator Superfamily
INS88_00550	COG1802	Transcriptional regulator
INS88_00560	COG3971	2-oxopent-4-enoate hydratase activity
INS88_00575	COG1904	glucuronate isomerase
INS88_00580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INS88_00600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS88_00615	COG4605	iron ion homeostasis
INS88_00620	COG4604	ABC transporter, ATP-binding protein
INS88_00630	COG3962	Belongs to the TPP enzyme family
INS88_00635	COG3718	enzyme involved in inositol metabolism
INS88_00655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS88_00660	COG0673	inositol 2-dehydrogenase activity
INS88_00670	COG2814	Major facilitator Superfamily
INS88_00680	COG4604	ABC transporter, ATP-binding protein
INS88_00695	COG2217	Heavy metal translocating P-type atpase
INS88_00710	COG0586	Pfam SNARE associated Golgi protein
INS88_00715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INS88_00720	COG3001	Fructosamine kinase
INS88_00725	COG1950	PFAM Membrane protein of
INS88_00730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INS88_00745	COG0714	Associated with various cellular activities
INS88_00775	COG0710	3-dehydroquinate dehydratase activity
INS88_00795	COG0667	Aldo Keto reductase
INS88_00800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS88_00830	COG3345	alpha-galactosidase
INS88_00870	COG1802	Transcriptional regulator
INS88_00870	COG4626	Terminase
INS88_00935	COG0717	Belongs to the dCTP deaminase family
INS88_00940	COG2111	Na H antiporter
INS88_00940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS88_00945	COG1006	Multisubunit Na H antiporter MnhC subunit
INS88_00950	COG0651	ATP synthesis coupled electron transport
INS88_00975	COG4143	(ABC) transporter
INS88_00985	COG3842	ATPase activity
INS88_01010	COG0662	Cupin 2, conserved barrel domain protein
INS88_01020	COG1940	carbohydrate kinase activity
INS88_01025	COG0390	transport system, permease component
INS88_01035	COG1505	serine-type exopeptidase activity
INS88_01045	COG0437	4 iron, 4 sulfur cluster binding
INS88_01050	COG0243	molybdopterin cofactor binding
INS88_01055	COG1937	Protein conserved in bacteria
INS88_01060	COG0446	pyridine nucleotide-disulphide oxidoreductase
INS88_01075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INS88_01080	COG0540	Belongs to the ATCase OTCase family
INS88_01085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INS88_01090	COG0284	orotidine-5'-phosphate decarboxylase activity
INS88_01095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INS88_01110	COG0167	dihydroorotate dehydrogenase activity
INS88_01115	COG0443	Heat shock 70 kDa protein
INS88_01120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INS88_01125	COG0484	heat shock protein binding
INS88_01130	COG0789	Transcriptional regulator
INS88_01140	COG0584	glycerophosphoryl diester phosphodiesterase
INS88_01145	COG0823	Involved in the tonB-independent uptake of proteins
INS88_01145	COG1506	peptidase
INS88_01160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INS88_01165	COG3949	Membrane
INS88_01220	COG0494	nUDIX hydrolase
INS88_01240	COG0191	fructose-bisphosphate aldolase activity
INS88_01245	COG2826	transposase and inactivated derivatives, IS30 family
INS88_01255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INS88_01260	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
INS88_01265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS88_01280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INS88_01290	COG0557	exoribonuclease II activity
INS88_01315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS88_01350	COG0039	L-malate dehydrogenase activity
INS88_01365	COG2348	transferase activity, transferring amino-acyl groups
INS88_01400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS88_01425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INS88_01430	COG0494	nUDIX hydrolase
INS88_01430	COG0406	alpha-ribazole phosphatase activity
INS88_01435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS88_01450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INS88_01455	COG0306	phosphate transporter
INS88_01465	COG1115	amino acid carrier protein
INS88_01475	COG3485	protocatechuate 3,4-dioxygenase
INS88_01495	COG1490	D-aminoacyl-tRNA deacylase activity
INS88_01505	COG1063	alcohol dehydrogenase
INS88_01510	COG2610	gluconate transmembrane transporter activity
INS88_01515	COG0246	Mannitol dehydrogenase
INS88_01525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS88_01540	COG0738	Major facilitator superfamily
INS88_01545	COG2390	Transcriptional regulator
INS88_01555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INS88_01560	COG1070	Carbohydrate kinase
INS88_01585	COG2376	Dihydroxyacetone kinase
INS88_01595	COG0698	ribose 5-phosphate isomerase
INS88_01620	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_01625	COG3250	beta-galactosidase activity
INS88_01635	COG2226	methyltransferase
INS88_01655	COG0730	response to heat
INS88_01660	COG0641	radical SAM
INS88_01665	COG2271	Major facilitator Superfamily
INS88_01670	COG1609	Transcriptional regulator
INS88_01675	COG3119	arylsulfatase activity
INS88_01680	COG1252	NADH dehydrogenase
INS88_01690	COG1609	Transcriptional regulator
INS88_01700	COG3250	beta-galactosidase activity
INS88_01715	COG1175	transmembrane transport
INS88_01720	COG0395	ABC-type sugar transport system, permease component
INS88_01730	COG1715	Restriction endonuclease
INS88_01750	COG2963	transposase activity
INS88_01755	COG3421	Type III restriction
INS88_01760	COG2189	Belongs to the N(4) N(6)-methyltransferase family
INS88_01820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS88_01825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_01825	COG0574	Belongs to the PEP-utilizing enzyme family
INS88_01840	COG0366	Alpha amylase catalytic
INS88_01845	COG0395	ABC-type sugar transport system, permease component
INS88_01850	COG1175	transmembrane transport
INS88_01880	COG0277	FAD linked oxidase domain protein
INS88_01880	COG0247	lactate metabolic process
INS88_01890	COG2267	carboxylic ester hydrolase activity
INS88_01895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
INS88_01900	COG0791	NLP P60 protein
INS88_01905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INS88_01920	COG0037	tRNA processing
INS88_01925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INS88_01930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INS88_01935	COG0302	gtp cyclohydrolase
INS88_01940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INS88_01945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INS88_01965	COG1609	Transcriptional regulator
INS88_01985	COG3250	beta-galactosidase activity
INS88_01990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_01990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS88_01995	COG1461	Dihydroxyacetone kinase
INS88_02000	COG2376	Dihydroxyacetone kinase
INS88_02010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INS88_02015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INS88_02025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS88_02030	COG2409	Drug exporters of the RND superfamily
INS88_02035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS88_02040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INS88_02055	COG1131	(ABC) transporter
INS88_02070	COG0247	lactate metabolic process
INS88_02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INS88_02085	COG2390	Transcriptional regulator
INS88_02090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INS88_02100	COG1194	a g-specific adenine glycosylase
INS88_02110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INS88_02115	COG0569	domain protein
INS88_02120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS88_02140	COG0406	alpha-ribazole phosphatase activity
INS88_02165	COG0395	ABC-type sugar transport system, permease component
INS88_02170	COG1177	transmembrane transport
INS88_02175	COG1653	transport
INS88_02180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INS88_02185	COG4948	Mandelate Racemase Muconate Lactonizing
INS88_02190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INS88_02205	COG2226	methyltransferase
INS88_02210	COG0644	oxidoreductase
INS88_02220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_02225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_02230	COG0649	NAD binding
INS88_02240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
INS88_02245	COG1034	ATP synthesis coupled electron transport
INS88_02250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INS88_02255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_02265	COG0713	ATP synthesis coupled electron transport
INS88_02270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS88_02280	COG1007	ATP synthesis coupled electron transport
INS88_02285	COG0142	geranyltranstransferase activity
INS88_02290	COG0653	protein targeting
INS88_02330	COG0419	ATPase involved in DNA repair
INS88_02335	COG0420	3'-5' exonuclease activity
INS88_02340	COG0483	inositol monophosphate 1-phosphatase activity
INS88_02350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INS88_02365	COG0657	acetylesterase activity
INS88_02375	COG0747	negative chemotaxis
INS88_02380	COG0601	transmembrane transport
INS88_02385	COG0444	Belongs to the ABC transporter superfamily
INS88_02390	COG4608	Belongs to the ABC transporter superfamily
INS88_02395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS88_02400	COG1846	Transcriptional regulator
INS88_02400	COG1940	carbohydrate kinase activity
INS88_02405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INS88_02410	COG0363	glucosamine-6-phosphate deaminase activity
INS88_02415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INS88_02420	COG1595	DNA-templated transcription, initiation
INS88_02430	COG1388	LysM domain
INS88_02430	COG3103	Sh3 type 3 domain protein
INS88_02430	COG0791	NLP P60 protein
INS88_02440	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS88_02440	COG0567	Dehydrogenase, E1 component
INS88_02445	COG1253	flavin adenine dinucleotide binding
INS88_02455	COG4942	peptidase
INS88_02455	COG1388	LysM domain
INS88_02485	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_02490	COG2826	transposase and inactivated derivatives, IS30 family
INS88_02495	COG2963	transposase activity
INS88_02510	COG2801	Transposase and inactivated derivatives
INS88_02535	COG0018	arginyl-trna synthetase
INS88_02540	COG0019	diaminopimelate decarboxylase activity
INS88_02545	COG0460	homoserine dehydrogenase
INS88_02550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INS88_02555	COG0083	homoserine kinase activity
INS88_02570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INS88_02575	COG2890	protein-(glutamine-N5) methyltransferase activity
INS88_02595	COG0356	it plays a direct role in the translocation of protons across the membrane
INS88_02600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS88_02605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INS88_02610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS88_02615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INS88_02620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INS88_02625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INS88_02640	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
INS88_02675	COG0366	Alpha amylase catalytic
INS88_02690	COG1175	transmembrane transport
INS88_02695	COG3833	ABC-type maltose transport systems, permease component
INS88_02710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INS88_02725	COG0366	Alpha amylase catalytic
INS88_02735	COG0058	SHG alpha-glucan phosphorylase activity
INS88_02740	COG0180	Tryptophanyl-tRNA synthetase
INS88_02770	COG3480	Lon protease (S16) C-terminal proteolytic domain
INS88_02780	COG1615	UPF0182 protein
INS88_02785	COG1470	cell adhesion involved in biofilm formation
INS88_02785	COG0366	Alpha amylase catalytic
INS88_02810	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_02820	COG1725	Transcriptional regulator
INS88_02825	COG1131	(ABC) transporter
INS88_02835	COG0387	Pfam Sodium calcium exchanger
INS88_02845	COG1053	succinate dehydrogenase
INS88_02850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS88_02865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INS88_02870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INS88_02885	COG4989	oxidoreductase activity
INS88_02900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS88_02910	COG4585	Histidine kinase
INS88_02915	COG2135	peptidase activity
INS88_02920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INS88_02925	COG1404	Belongs to the peptidase S8 family
INS88_02935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS88_02940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS88_02945	COG0154	amidase activity
INS88_02950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS88_03010	COG0129	dihydroxy-acid dehydratase activity
INS88_03015	COG0569	domain protein
INS88_03015	COG2985	domain, Protein
INS88_03025	COG0440	acetolactate synthase activity
INS88_03030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INS88_03050	COG0473	3-isopropylmalate dehydrogenase activity
INS88_03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INS88_03060	COG1882	Formate acetyltransferase
INS88_03095	COG4750	Nucleotidyl transferase
INS88_03100	COG3475	LICD family
INS88_03105	COG1216	Glycosyl transferase, family 2
INS88_03105	COG1442	glycosyl transferase family 8
INS88_03120	COG0463	Glycosyl transferase, family 2
INS88_03130	COG2244	polysaccharide biosynthetic process
INS88_03135	COG1216	Glycosyl transferase, family 2
INS88_03135	COG0463	Glycosyl transferase, family 2
INS88_03160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
INS88_03170	COG1162	GTPase activity
INS88_03200	COG1263	PTS System
INS88_03200	COG2190	(PTS) system
INS88_03200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS88_03205	COG2818	Glycosylase
INS88_03220	COG2354	Protein conserved in bacteria
INS88_03225	COG3590	peptidase
INS88_03235	COG1045	serine acetyltransferase
INS88_03245	COG1739	Uncharacterized protein family UPF0029
INS88_03275	COG0393	Putative heavy-metal-binding
INS88_03300	COG0667	Aldo Keto reductase
INS88_03305	COG0544	peptidyl-prolyl cis-trans isomerase activity
INS88_03310	COG0740	serine-type endopeptidase activity
INS88_03315	COG0740	serine-type endopeptidase activity
INS88_03325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INS88_03330	COG0287	Prephenate dehydrogenase
INS88_03330	COG1605	Chorismate mutase
INS88_03350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INS88_03365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INS88_03370	COG0285	dihydrofolate synthase activity
INS88_03380	COG0105	UTP biosynthetic process
INS88_03395	COG3069	C4-dicarboxylate transmembrane transporter activity
INS88_03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INS88_03430	COG1837	Belongs to the UPF0109 family
INS88_03435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INS88_03445	COG0335	large ribosomal subunit rRNA binding
INS88_03450	COG0681	Belongs to the peptidase S26 family
INS88_03455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INS88_03465	COG0792	nuclease activity
INS88_03480	COG4974	Belongs to the 'phage' integrase family
INS88_03490	COG2860	membrane
INS88_03495	COG0052	Belongs to the universal ribosomal protein uS2 family
INS88_03500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INS88_03510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INS88_03515	COG0644	oxidoreductase
INS88_03535	COG0528	UMP kinase activity
INS88_03540	COG0233	cytoplasmic translational termination
INS88_03550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INS88_03560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INS88_03565	COG0750	zinc metalloprotease
INS88_03570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INS88_03580	COG0442	prolyl-tRNA aminoacylation
INS88_03590	COG0779	Required for maturation of 30S ribosomal subunits
INS88_03605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INS88_03610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INS88_03615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INS88_03620	COG5002	protein histidine kinase activity
INS88_03630	COG2271	Major facilitator Superfamily
INS88_03640	COG3842	ATPase activity
INS88_03670	COG1131	(ABC) transporter
INS88_03725	COG2963	transposase activity
INS88_03735	COG1185	polyribonucleotide nucleotidyltransferase activity
INS88_03745	COG0612	Peptidase, M16
INS88_03750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INS88_03755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INS88_03770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS88_03775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
INS88_03780	COG1674	ftsk spoiiie
INS88_03795	COG1058	Belongs to the CinA family
INS88_03795	COG1546	Belongs to the CinA family
INS88_03800	COG1396	sequence-specific DNA binding
INS88_03810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INS88_03815	COG2137	regulation of response to DNA damage stimulus
INS88_03820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INS88_03825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INS88_03830	COG2813	Specifically methylates the guanine in position
INS88_03835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INS88_03855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INS88_03860	COG0318	PFAM AMP-dependent synthetase and ligase
INS88_03865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INS88_03890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INS88_03900	COG2001	Belongs to the MraZ family
INS88_03905	COG0275	rRNA processing
INS88_03915	COG0768	penicillin binding
INS88_03920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INS88_03925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INS88_03930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INS88_03935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INS88_03945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INS88_03950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INS88_03960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INS88_03965	COG1496	oxidoreductase activity
INS88_03970	COG1799	cell septum assembly
INS88_03985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INS88_04000	COG0587	DNA-directed DNA polymerase activity
INS88_04005	COG2501	S4 domain
INS88_04020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_04025	COG1121	(ABC) transporter
INS88_04035	COG0423	glycine-tRNA ligase activity
INS88_04045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INS88_04060	COG0358	DNA primase activity
INS88_04070	COG0805	protein transport
INS88_04075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS88_04080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS88_04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_04115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
INS88_04160	COG1090	epimerase
INS88_04180	COG0009	L-threonylcarbamoyladenylate synthase
INS88_04205	COG0477	Major facilitator Superfamily
INS88_04210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
INS88_04235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS88_04240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS88_04245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INS88_04265	COG1940	carbohydrate kinase activity
INS88_04280	COG0174	glutamine synthetase
INS88_04285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
INS88_04315	COG0174	glutamine synthetase
INS88_04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS88_04340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS88_04350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
INS88_04365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_04415	COG0205	6-phosphofructokinase activity
INS88_04420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
INS88_04425	COG0515	serine threonine protein kinase
INS88_04425	COG2815	serine threonine protein kinase
INS88_04440	COG0142	geranyltranstransferase activity
INS88_04455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INS88_04470	COG0187	DNA topoisomerase II activity
INS88_04485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS88_04530	COG0569	domain protein
INS88_04545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INS88_04550	COG2826	transposase and inactivated derivatives, IS30 family
INS88_04555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INS88_04560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INS88_04620	COG2197	response regulator
INS88_04625	COG1760	l-serine dehydratase
INS88_04630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INS88_04635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INS88_04645	COG0438	transferase activity, transferring glycosyl groups
INS88_04665	COG0217	transcriptional regulatory protein
INS88_04670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INS88_04675	COG0632	four-way junction helicase activity
INS88_04680	COG2255	four-way junction helicase activity
INS88_04690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS88_04695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS88_04700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INS88_04705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INS88_04715	COG1196	nuclear chromosome segregation
INS88_04725	COG0124	histidyl-tRNA synthetase
INS88_04730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INS88_04735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INS88_04750	COG2814	Major facilitator Superfamily
INS88_04755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INS88_04770	COG2409	Drug exporters of the RND superfamily
INS88_04780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INS88_04790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INS88_04795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INS88_04815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INS88_04835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INS88_04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INS88_04845	COG0505	Belongs to the CarA family
INS88_04850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INS88_04860	COG0194	GDP metabolic process
INS88_04865	COG1758	RNA polymerase activity
INS88_04875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS88_04885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INS88_04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INS88_04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INS88_04905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INS88_04910	COG0140	phosphoribosyl-ATP diphosphatase activity
INS88_04915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INS88_04955	COG1216	Glycosyl transferase, family 2
INS88_04980	COG1716	ATPase activity
INS88_04990	COG1834	amidinotransferase
INS88_05000	COG0205	6-phosphofructokinase activity
INS88_05005	COG1160	GTP binding
INS88_05010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INS88_05020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INS88_05045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS88_05060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INS88_05065	COG0149	triose-phosphate isomerase activity
INS88_05070	COG0126	phosphoglycerate kinase activity
INS88_05075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INS88_05080	COG1481	regulation of sporulation
INS88_05095	COG0322	excinuclease ABC activity
INS88_05120	COG0556	nucleotide-excision repair
INS88_05125	COG0237	dephospho-CoA kinase activity
INS88_05130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
INS88_05135	COG0539	negative regulation of cytoplasmic translation
INS88_05140	COG2226	methyltransferase
INS88_05165	COG0469	pyruvate kinase activity
INS88_05170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INS88_05180	COG0133	tryptophan synthase activity
INS88_05185	COG0134	indole-3-glycerol-phosphate synthase activity
INS88_05195	COG0107	imidazoleglycerol-phosphate synthase activity
INS88_05210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
INS88_05220	COG4122	O-methyltransferase activity
INS88_05225	COG1222	aaa ATPase
INS88_05240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INS88_05245	COG1968	undecaprenyl-diphosphatase activity
INS88_05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_05265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INS88_05270	COG0519	Catalyzes the synthesis of GMP from XMP
INS88_05275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INS88_05295	COG0587	DNA-directed DNA polymerase activity
INS88_05310	COG1881	PFAM PEBP family protein
INS88_05315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INS88_05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_05345	COG1119	ATPase activity
INS88_05350	COG0297	glycogen (starch) synthase activity
INS88_05360	COG0560	Phosphoserine phosphatase
INS88_05360	COG3830	Belongs to the UPF0237 family
INS88_05375	COG0488	(ABC) transporter
INS88_05385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INS88_05390	COG2151	metal-sulfur cluster biosynthetic enzyme
INS88_05415	COG0719	Fe-S assembly protein
INS88_05435	COG0728	peptidoglycan biosynthetic process
INS88_05455	COG0497	DNA recombination
INS88_05460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INS88_05475	COG0647	UMP catabolic process
INS88_05500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_05505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_05510	COG1121	(ABC) transporter
INS88_05520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INS88_05535	COG1476	TRANSCRIPTIONal
INS88_05540	COG0165	Argininosuccinate lyase
INS88_05545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INS88_05550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INS88_05560	COG0137	argininosuccinate synthase activity
INS88_05570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INS88_05575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INS88_05580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
INS88_05585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INS88_05595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INS88_05600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INS88_05620	COG1902	pentaerythritol trinitrate reductase activity
INS88_05625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_05640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INS88_05645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INS88_05655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INS88_05660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INS88_05670	COG0131	Imidazoleglycerol-phosphate dehydratase
INS88_05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INS88_05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS88_05690	COG1381	Involved in DNA repair and RecF pathway recombination
INS88_05695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS88_05710	COG0631	protein serine/threonine phosphatase activity
INS88_05730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INS88_05745	COG0484	heat shock protein binding
INS88_05750	COG1420	regulation of RNA biosynthetic process
INS88_05770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INS88_05775	COG0481	GTPase activity
INS88_05795	COG3237	CsbD-like
INS88_05800	COG0268	Binds directly to 16S ribosomal RNA
INS88_05805	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
INS88_05810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
INS88_05825	COG1596	polysaccharide export
INS88_05825	COG1555	photosystem II stabilization
INS88_05830	COG0433	COG0433 Predicted ATPase
INS88_05840	COG0495	leucyl-tRNA aminoacylation
INS88_05865	COG0813	purine-nucleoside phosphorylase activity
INS88_05870	COG1321	iron dependent repressor
INS88_05870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_05875	COG1435	thymidine kinase activity
INS88_05905	COG1121	(ABC) transporter
INS88_05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_05930	COG0671	phosphoesterase, PA-phosphatase related
INS88_05950	COG1113	amino acid transport
INS88_05960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INS88_05960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INS88_05965	COG2826	transposase and inactivated derivatives, IS30 family
INS88_05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS88_05975	COG2011	ABC-type metal ion transport system permease component
INS88_05985	COG1113	amino acid transport
INS88_05995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
INS88_06000	COG0826	peptidase U32
INS88_06005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
INS88_06010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
INS88_06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS88_06040	COG1609	Transcriptional regulator
INS88_06045	COG3250	beta-galactosidase activity
INS88_06075	COG0133	tryptophan synthase activity
INS88_06110	COG2801	Transposase and inactivated derivatives
INS88_06145	COG1136	(ABC) transporter
INS88_06160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS88_06175	COG0406	alpha-ribazole phosphatase activity
INS88_06180	COG0799	negative regulation of ribosome biogenesis
INS88_06190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INS88_06195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INS88_06205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INS88_06210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INS88_06215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INS88_06220	COG1530	ribonuclease E activity
INS88_06225	COG1271	oxidase subunit
INS88_06230	COG1294	oxidase, subunit
INS88_06235	COG4988	ABC transporter
INS88_06250	COG1132	(ABC) transporter
INS88_06255	COG1132	(ABC) transporter
INS88_06275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INS88_06280	COG0571	ribonuclease III activity
INS88_06295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INS88_06305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INS88_06310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS88_06330	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS88_06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INS88_06355	COG0066	3-isopropylmalate dehydratase activity
INS88_06360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INS88_06370	COG0438	transferase activity, transferring glycosyl groups
INS88_06385	COG4975	Glucose uptake
INS88_06390	COG0339	signal peptide processing
INS88_06450	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS88_06455	COG1022	Amp-dependent synthetase and ligase
INS88_06480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INS88_06485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INS88_06490	COG1234	tRNA 3'-trailer cleavage
INS88_06495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INS88_06505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INS88_06530	COG0569	domain protein
INS88_06530	COG2985	domain, Protein
INS88_06545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INS88_06560	COG0737	Belongs to the 5'-nucleotidase family
INS88_06580	COG0778	Nitroreductase
INS88_06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_06685	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_06700	COG2890	protein-(glutamine-N5) methyltransferase activity
INS88_06720	COG0352	thiamine-phosphate diphosphorylase activity
INS88_06725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
INS88_06730	COG0477	Major facilitator Superfamily
INS88_06735	COG0351	phosphomethylpyrimidine kinase
INS88_06735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
INS88_06735	COG0352	thiamine-phosphate diphosphorylase activity
INS88_06770	COG1619	proteins homologs of microcin C7 resistance protein MccF
INS88_06780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INS88_06785	COG0739	heme binding
INS88_06790	COG2177	Part of the ABC transporter FtsEX involved in
INS88_06795	COG2884	Cell division ATP-binding protein ftsE
INS88_06800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INS88_06875	COG0513	Belongs to the DEAD box helicase family
INS88_06880	COG2095	MarC family integral membrane protein
INS88_06890	COG0006	proline dipeptidase activity
INS88_06895	COG2239	Acts as a magnesium transporter
INS88_06920	COG1611	Belongs to the LOG family
INS88_06930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INS88_06935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INS88_06955	COG1079	Belongs to the binding-protein-dependent transport system permease family
INS88_06960	COG4603	Belongs to the binding-protein-dependent transport system permease family
INS88_06965	COG3845	ABC transporter
INS88_06970	COG1744	ABC transporter substrate-binding protein PnrA-like
INS88_06990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INS88_06995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INS88_07005	COG1268	BioY protein
INS88_07010	COG0736	holo-[acyl-carrier-protein] synthase activity
INS88_07015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INS88_07020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INS88_07025	COG4770	biotin carboxylase activity
INS88_07045	COG0644	oxidoreductase
INS88_07070	COG2271	Major facilitator Superfamily
INS88_07075	COG2030	dehydratase
INS88_07105	COG0110	maltose O-acetyltransferase activity
INS88_07115	COG0039	L-malate dehydrogenase activity
INS88_07130	COG0166	Belongs to the GPI family
INS88_07135	COG0205	6-phosphofructokinase activity
INS88_07165	COG0045	succinate-CoA ligase (ADP-forming) activity
INS88_07170	COG2755	lipolytic protein G-D-S-L family
INS88_07170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INS88_07180	COG5646	InterPro IPR014922
INS88_07200	COG0564	pseudouridine synthase activity
INS88_07205	COG0280	phosphate acetyltransferase
INS88_07205	COG0857	belongs to the CobB CobQ family
INS88_07210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INS88_07225	COG1136	(ABC) transporter
INS88_07235	COG0114	fumarate hydratase activity
INS88_07240	COG0516	GMP reductase activity
INS88_07260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INS88_07265	COG0151	Belongs to the GarS family
INS88_07270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INS88_07275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INS88_07280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INS88_07285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS88_07290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INS88_07300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INS88_07315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INS88_07320	COG0733	neurotransmitter:sodium symporter activity
INS88_07330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS88_07335	COG1053	succinate dehydrogenase
INS88_07360	COG0802	atpase or kinase
INS88_07365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INS88_07375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INS88_07380	COG1072	(Pantothenic acid kinase))
INS88_07390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INS88_07395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INS88_07405	COG4720	Psort location CytoplasmicMembrane, score
INS88_07410	COG1122	ATPase activity
INS88_07415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INS88_07430	COG0101	tRNA pseudouridine synthase activity
INS88_07435	COG1940	carbohydrate kinase activity
INS88_07445	COG0765	amino acid transport
INS88_07450	COG1126	abc transporter atp-binding protein
INS88_07455	COG0640	Transcriptional regulator
INS88_07465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INS88_07475	COG0789	Transcriptional regulator
INS88_07480	COG0203	ribosomal protein L17
INS88_07485	COG0202	RNA polymerase activity
INS88_07495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INS88_07500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS88_07505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INS88_07510	COG0024	Methionine aminopeptidase
INS88_07515	COG0563	adenylate kinase activity
INS88_07530	COG0200	Binds to the 23S rRNA
INS88_07535	COG1841	ribosomal large subunit assembly
INS88_07540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INS88_07550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INS88_07555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INS88_07560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS88_07565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INS88_07570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INS88_07575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INS88_07590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INS88_07595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INS88_07600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INS88_07605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INS88_07610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INS88_07615	COG0089	rRNA binding
INS88_07620	COG0088	Forms part of the polypeptide exit tunnel
INS88_07625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INS88_07630	COG0051	transcription antitermination factor activity, RNA binding
INS88_07640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INS88_07645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INS88_07650	COG0049	tRNA binding
INS88_07655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INS88_07660	COG0833	amino acid
INS88_07665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INS88_07670	COG0085	RNA polymerase activity
INS88_07675	COG0222	ribosome binding
INS88_07680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INS88_07685	COG0572	uridine kinase
INS88_07690	COG0081	regulation of translation
INS88_07695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INS88_07715	COG0436	Aminotransferase
INS88_07725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
INS88_07740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INS88_07745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS88_07765	COG1666	GTP binding
INS88_07775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INS88_07785	COG5401	PFAM Sporulation and spore germination
INS88_07790	COG5002	protein histidine kinase activity
INS88_07795	COG0745	RESPONSE REGULATOR receiver
INS88_07815	COG0714	Associated with various cellular activities
INS88_07860	COG0483	inositol monophosphate 1-phosphatase activity
INS88_07875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INS88_07915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INS88_07955	COG0438	transferase activity, transferring glycosyl groups
INS88_07965	COG0673	inositol 2-dehydrogenase activity
INS88_07975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS88_07990	COG1088	dTDP-glucose 4,6-dehydratase activity
INS88_08010	COG1316	TRANSCRIPTIONal
INS88_08020	COG0642	Histidine kinase
INS88_08025	COG0745	RESPONSE REGULATOR receiver
INS88_08040	COG0424	maF-like protein
INS88_08075	COG1217	gtp-binding protein TYPA
INS88_08085	COG1132	(ABC) transporter
INS88_08090	COG1132	(ABC) transporter
INS88_08115	COG0321	lipoyl(octanoyl) transferase activity
INS88_08120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INS88_08130	COG1362	aminopeptidase activity
INS88_08145	COG2838	Isocitrate dehydrogenase
INS88_08150	COG2391	methyltransferase activity
INS88_08155	COG0425	Belongs to the sulfur carrier protein TusA family
INS88_08175	COG2116	formate transmembrane transporter activity
INS88_08185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INS88_08195	COG0242	peptide deformylase activity
INS88_08200	COG1970	mechanosensitive ion channel activity
INS88_08210	COG1174	glycine betaine transport
INS88_08225	COG0778	Nitroreductase
INS88_08250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS88_08250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INS88_08300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS88_08315	COG0697	spore germination
INS88_08365	COG4824	toxin secretion phage lysis holin
INS88_08435	COG0740	serine-type endopeptidase activity
INS88_08440	COG4695	Portal protein
INS88_08455	COG1802	Transcriptional regulator
INS88_08455	COG4626	Terminase
INS88_08540	COG0012	GTP binding
INS88_08545	COG1322	Protein conserved in bacteria
INS88_08550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INS88_08555	COG1570	exodeoxyribonuclease VII activity
INS88_08560	COG1722	exodeoxyribonuclease VII activity
INS88_08565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS88_08570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS88_08585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INS88_08590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INS88_08595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS88_08605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INS88_08610	COG1012	belongs to the aldehyde dehydrogenase family
INS88_08625	COG1131	(ABC) transporter
INS88_08655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS88_08680	COG0148	phosphopyruvate hydratase activity
INS88_08695	COG0193	aminoacyl-tRNA hydrolase activity
INS88_08705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INS88_08710	COG1136	(ABC) transporter
INS88_08720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS88_08735	COG4152	abc transporter atp-binding protein
INS88_08740	COG1668	transmembrane transport
INS88_08750	COG0488	(ABC) transporter
INS88_08755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INS88_08760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INS88_08770	COG0084	hydrolase, TatD family'
INS88_08775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INS88_08785	COG1335	isochorismatase
INS88_08805	COG2873	o-acetylhomoserine
INS88_08815	COG1131	(ABC) transporter
INS88_08830	COG2813	Specifically methylates the guanine in position
INS88_08835	COG0667	Aldo Keto reductase
INS88_08840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS88_08855	COG1120	ATPase activity
INS88_08860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_08870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS88_08895	COG1620	l-lactate permease
INS88_08900	COG0247	lactate metabolic process
INS88_08910	COG1556	Lactate utilization protein
INS88_08930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS88_08940	COG1263	PTS System
INS88_08940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS88_08955	COG1131	(ABC) transporter
INS88_08960	COG1051	belongs to the nudix hydrolase family
INS88_08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_08975	COG3711	transcriptional antiterminator
INS88_08990	COG1511	domain protein
INS88_09000	COG2848	UPF0210 protein
INS88_09005	COG3830	Belongs to the UPF0237 family
INS88_09010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS88_09015	COG0254	rRNA binding
INS88_09020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS88_09025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS88_09030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS88_09045	COG0477	Major facilitator Superfamily
INS88_09050	COG0657	acetylesterase activity
INS88_09055	COG2188	Transcriptional regulator
INS88_09060	COG1120	ATPase activity
INS88_09065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_09070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_09075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
INS88_09085	COG0488	(ABC) transporter
INS88_09165	COG1321	iron dependent repressor
INS88_09175	COG2252	PERMEase
INS88_09180	COG1482	cell wall glycoprotein biosynthetic process
INS88_09190	COG1278	Cold shock
INS88_09200	COG1842	Phage shock protein A
INS88_09210	COG0745	RESPONSE REGULATOR receiver
INS88_09215	COG2205	protein histidine kinase activity
INS88_09225	COG4221	oxidoreductase activity
INS88_09235	COG0459	protein refolding
INS88_09250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INS88_09260	COG0395	ABC-type sugar transport system, permease component
INS88_09265	COG1175	transmembrane transport
INS88_09285	COG1609	Transcriptional regulator
INS88_09295	COG4974	Belongs to the 'phage' integrase family
INS88_09370	COG0741	lytic transglycosylase activity
INS88_09540	COG3842	ATPase activity
INS88_09555	COG1653	transport
INS88_09560	COG1175	transmembrane transport
INS88_09590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INS88_09630	COG2233	PERMEase
INS88_09645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_09650	COG0215	cysteine-tRNA ligase activity
INS88_09660	COG1136	(ABC) transporter
INS88_09675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INS88_09680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INS88_09690	COG0745	RESPONSE REGULATOR receiver
INS88_09700	COG0704	Plays a role in the regulation of phosphate uptake
INS88_09710	COG0588	phosphoglycerate mutase activity
INS88_09750	COG4974	Belongs to the 'phage' integrase family
INS88_09760	COG1192	Involved in chromosome partitioning
INS88_09780	COG2184	nucleotidyltransferase activity
INS88_09880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INS88_09885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INS88_09890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INS88_09890	COG1754	DNA topoisomerase type I activity
INS88_09905	COG3655	Transcriptional regulator
INS88_09910	COG1111	helicase
INS88_09910	COG1205	dead DEAH box helicase
INS88_09955	COG0596	Alpha beta hydrolase
INS88_09985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS88_10015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INS88_10025	COG0315	cyclic pyranopterin monophosphate synthase activity
INS88_10035	COG0521	Mo-molybdopterin cofactor biosynthetic process
INS88_10040	COG0725	ABC transporter, periplasmic molybdate-binding protein
INS88_10090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INS88_10095	COG4868	Belongs to the UPF0371 family
INS88_10100	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_10105	COG1114	Component of the transport system for branched-chain amino acids
INS88_10115	COG0590	tRNA wobble adenosine to inosine editing
INS88_10120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INS88_10135	COG1215	transferase activity, transferring glycosyl groups
INS88_10145	COG0077	Prephenate dehydratase
INS88_10155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INS88_10160	COG0561	phosphatase activity
INS88_10185	COG0471	metal ion transport
INS88_10215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INS88_10225	COG1518	maintenance of DNA repeat elements
INS88_10265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INS88_10280	COG1643	Atp-dependent helicase
INS88_10290	COG0569	domain protein
INS88_10295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS88_10315	COG1136	(ABC) transporter
INS88_10315	COG0577	efflux transmembrane transporter activity
INS88_10320	COG1136	(ABC) transporter
INS88_10320	COG0577	efflux transmembrane transporter activity
INS88_10335	COG0745	RESPONSE REGULATOR receiver
INS88_10340	COG2205	protein histidine kinase activity
INS88_10345	COG0343	queuine tRNA-ribosyltransferase activity
INS88_10355	COG1428	Deoxynucleoside kinase
INS88_10395	COG0656	L-ascorbic acid biosynthetic process
INS88_10400	COG0351	phosphomethylpyrimidine kinase
INS88_10415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INS88_10420	COG0084	hydrolase, TatD family'
INS88_10430	COG0305	Participates in initiation and elongation during chromosome replication
INS88_10450	COG0359	binds to the 23S rRNA
INS88_10455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INS88_10465	COG0360	Binds together with S18 to 16S ribosomal RNA
INS88_10470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS88_10475	COG0628	permease
INS88_10505	COG0492	ferredoxin-NADP+ reductase activity
INS88_10510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS88_10515	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS88_10530	COG0357	Ribosomal RNA small subunit methyltransferase G
INS88_10540	COG0706	membrane insertase activity
INS88_10545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INS88_10550	COG0594	ribonuclease P activity
INS88_10555	COG0230	Belongs to the bacterial ribosomal protein bL34 family