locus-tag	class	description
INS90_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INS90_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INS90_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
INS90_00025	COG0187	DNA topoisomerase II activity
INS90_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS90_00085	COG3764	Sortase (surface protein transpeptidase)
INS90_00100	COG0768	penicillin binding
INS90_00105	COG0772	Belongs to the SEDS family
INS90_00120	COG0842	Transport permease protein
INS90_00120	COG1131	(ABC) transporter
INS90_00120	COG1716	ATPase activity
INS90_00155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INS90_00160	COG1854	S-ribosylhomocysteine lyase activity
INS90_00175	COG1780	Probably involved in ribonucleotide reductase function
INS90_00180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS90_00185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS90_00185	COG3253	May function as heme-dependent peroxidase
INS90_00190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INS90_00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS90_00220	COG1653	transport
INS90_00225	COG0395	ABC-type sugar transport system, permease component
INS90_00230	COG1175	transmembrane transport
INS90_00255	COG1643	Atp-dependent helicase
INS90_00260	COG2197	response regulator
INS90_00265	COG4585	Histidine kinase
INS90_00275	COG1131	(ABC) transporter
INS90_00285	COG1136	(ABC) transporter
INS90_00295	COG2197	response regulator
INS90_00310	COG1328	CTP reductase activity
INS90_00325	COG1414	Transcriptional regulator
INS90_00330	COG0246	Mannitol dehydrogenase
INS90_00335	COG1312	Catalyzes the dehydration of D-mannonate
INS90_00340	COG0800	Aldolase
INS90_00345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_00350	COG1609	Transcriptional regulator
INS90_00365	COG1175	transmembrane transport
INS90_00370	COG0395	ABC-type sugar transport system, permease component
INS90_00375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INS90_00400	COG2188	Transcriptional regulator
INS90_00410	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS90_00415	COG1879	ABC-type sugar transport system periplasmic component
INS90_00425	COG1486	melibiose metabolic process
INS90_00460	COG1940	carbohydrate kinase activity
INS90_00460	COG1846	Transcriptional regulator
INS90_00465	COG1940	carbohydrate kinase activity
INS90_00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INS90_00480	COG0601	transmembrane transport
INS90_00505	COG3142	Participates in the control of copper homeostasis
INS90_00525	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS90_00530	COG1012	belongs to the aldehyde dehydrogenase family
INS90_00540	COG0477	Major facilitator Superfamily
INS90_00545	COG1802	Transcriptional regulator
INS90_00555	COG3971	2-oxopent-4-enoate hydratase activity
INS90_00565	COG1904	glucuronate isomerase
INS90_00570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INS90_00575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
INS90_00590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS90_00600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_00605	COG4605	iron ion homeostasis
INS90_00610	COG4604	ABC transporter, ATP-binding protein
INS90_00620	COG3962	Belongs to the TPP enzyme family
INS90_00625	COG3718	enzyme involved in inositol metabolism
INS90_00645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS90_00650	COG0673	inositol 2-dehydrogenase activity
INS90_00660	COG2814	Major facilitator Superfamily
INS90_00675	COG4604	ABC transporter, ATP-binding protein
INS90_00710	COG0586	Pfam SNARE associated Golgi protein
INS90_00715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INS90_00720	COG3001	Fructosamine kinase
INS90_00725	COG1950	PFAM Membrane protein of
INS90_00730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INS90_00745	COG0714	Associated with various cellular activities
INS90_00800	COG0667	Aldo Keto reductase
INS90_00805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS90_00835	COG1129	ABC transporter
INS90_00845	COG1175	transmembrane transport
INS90_00850	COG0395	ABC-type sugar transport system, permease component
INS90_00860	COG3345	alpha-galactosidase
INS90_00880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
INS90_00920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS90_00975	COG1802	Transcriptional regulator
INS90_00975	COG4626	Terminase
INS90_01035	COG3177	Filamentation induced by cAMP protein fic
INS90_01060	COG0717	Belongs to the dCTP deaminase family
INS90_01065	COG2111	Na H antiporter
INS90_01065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS90_01070	COG1006	Multisubunit Na H antiporter MnhC subunit
INS90_01075	COG0651	ATP synthesis coupled electron transport
INS90_01100	COG4143	(ABC) transporter
INS90_01105	COG4149	molybdate abc transporter
INS90_01110	COG3842	ATPase activity
INS90_01135	COG0662	Cupin 2, conserved barrel domain protein
INS90_01155	COG1940	carbohydrate kinase activity
INS90_01160	COG0390	transport system, permease component
INS90_01170	COG1505	serine-type exopeptidase activity
INS90_01180	COG0437	4 iron, 4 sulfur cluster binding
INS90_01185	COG0243	molybdopterin cofactor binding
INS90_01190	COG1937	Protein conserved in bacteria
INS90_01195	COG0446	pyridine nucleotide-disulphide oxidoreductase
INS90_01210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INS90_01215	COG0540	Belongs to the ATCase OTCase family
INS90_01220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INS90_01225	COG0284	orotidine-5'-phosphate decarboxylase activity
INS90_01230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INS90_01245	COG0167	dihydroorotate dehydrogenase activity
INS90_01250	COG0443	Heat shock 70 kDa protein
INS90_01255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INS90_01260	COG0484	heat shock protein binding
INS90_01265	COG0789	Transcriptional regulator
INS90_01285	COG0584	glycerophosphoryl diester phosphodiesterase
INS90_01290	COG1506	peptidase
INS90_01290	COG0823	Involved in the tonB-independent uptake of proteins
INS90_01305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INS90_01310	COG3949	Membrane
INS90_01365	COG0494	nUDIX hydrolase
INS90_01380	COG0191	fructose-bisphosphate aldolase activity
INS90_01390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INS90_01395	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
INS90_01400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS90_01415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INS90_01425	COG0557	exoribonuclease II activity
INS90_01450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS90_01485	COG0039	L-malate dehydrogenase activity
INS90_01500	COG2348	transferase activity, transferring amino-acyl groups
INS90_01505	COG2348	transferase activity, transferring amino-acyl groups
INS90_01540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS90_01565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INS90_01570	COG0406	alpha-ribazole phosphatase activity
INS90_01570	COG0494	nUDIX hydrolase
INS90_01575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS90_01590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INS90_01595	COG0306	phosphate transporter
INS90_01605	COG1115	amino acid carrier protein
INS90_01615	COG3485	protocatechuate 3,4-dioxygenase
INS90_01635	COG1490	D-aminoacyl-tRNA deacylase activity
INS90_01655	COG0738	Major facilitator superfamily
INS90_01660	COG2390	Transcriptional regulator
INS90_01675	COG1070	Carbohydrate kinase
INS90_01680	COG1349	DNA-binding transcription factor activity
INS90_01700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS90_01710	COG2376	Dihydroxyacetone kinase
INS90_01715	COG1063	alcohol dehydrogenase
INS90_01720	COG0698	ribose 5-phosphate isomerase
INS90_01740	COG3250	beta-galactosidase activity
INS90_01750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_01755	COG1879	ABC-type sugar transport system periplasmic component
INS90_01760	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS90_01765	COG1129	ABC transporter
INS90_01770	COG1609	Transcriptional regulator
INS90_01800	COG2226	methyltransferase
INS90_01820	COG2176	DNA-directed DNA polymerase activity
INS90_01835	COG1252	NADH dehydrogenase
INS90_01855	COG1715	Restriction endonuclease
INS90_01875	COG2801	Transposase and inactivated derivatives
INS90_01890	COG1609	Transcriptional regulator
INS90_01915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS90_01925	COG0574	Belongs to the PEP-utilizing enzyme family
INS90_01925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_01940	COG0366	Alpha amylase catalytic
INS90_01945	COG0395	ABC-type sugar transport system, permease component
INS90_01950	COG1175	transmembrane transport
INS90_01985	COG0277	FAD linked oxidase domain protein
INS90_01985	COG0247	lactate metabolic process
INS90_01995	COG2267	carboxylic ester hydrolase activity
INS90_02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
INS90_02005	COG0791	NLP P60 protein
INS90_02010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INS90_02025	COG0037	tRNA processing
INS90_02030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INS90_02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INS90_02040	COG0302	gtp cyclohydrolase
INS90_02045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INS90_02050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INS90_02070	COG1609	Transcriptional regulator
INS90_02090	COG3250	beta-galactosidase activity
INS90_02095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS90_02095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_02100	COG1461	Dihydroxyacetone kinase
INS90_02105	COG2376	Dihydroxyacetone kinase
INS90_02115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INS90_02120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INS90_02130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS90_02135	COG2409	Drug exporters of the RND superfamily
INS90_02140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS90_02145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INS90_02160	COG1131	(ABC) transporter
INS90_02175	COG0247	lactate metabolic process
INS90_02185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INS90_02190	COG2390	Transcriptional regulator
INS90_02195	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INS90_02205	COG1194	a g-specific adenine glycosylase
INS90_02215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INS90_02220	COG0569	domain protein
INS90_02225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS90_02245	COG0406	alpha-ribazole phosphatase activity
INS90_02270	COG0395	ABC-type sugar transport system, permease component
INS90_02275	COG1177	transmembrane transport
INS90_02280	COG1653	transport
INS90_02285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INS90_02290	COG4948	Mandelate Racemase Muconate Lactonizing
INS90_02295	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INS90_02300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INS90_02310	COG2226	methyltransferase
INS90_02315	COG0644	oxidoreductase
INS90_02325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_02330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_02335	COG0649	NAD binding
INS90_02345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
INS90_02350	COG1034	ATP synthesis coupled electron transport
INS90_02355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INS90_02360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_02370	COG0713	ATP synthesis coupled electron transport
INS90_02375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS90_02385	COG1007	ATP synthesis coupled electron transport
INS90_02390	COG0142	geranyltranstransferase activity
INS90_02395	COG0653	protein targeting
INS90_02435	COG0419	ATPase involved in DNA repair
INS90_02440	COG0420	3'-5' exonuclease activity
INS90_02445	COG0483	inositol monophosphate 1-phosphatase activity
INS90_02455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INS90_02480	COG0747	negative chemotaxis
INS90_02485	COG0601	transmembrane transport
INS90_02490	COG0444	Belongs to the ABC transporter superfamily
INS90_02495	COG4608	Belongs to the ABC transporter superfamily
INS90_02500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS90_02505	COG1940	carbohydrate kinase activity
INS90_02505	COG1846	Transcriptional regulator
INS90_02510	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INS90_02515	COG0363	glucosamine-6-phosphate deaminase activity
INS90_02520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INS90_02525	COG1595	DNA-templated transcription, initiation
INS90_02540	COG1388	LysM domain
INS90_02540	COG0791	NLP P60 protein
INS90_02540	COG3103	Sh3 type 3 domain protein
INS90_02550	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS90_02550	COG0567	Dehydrogenase, E1 component
INS90_02555	COG1253	flavin adenine dinucleotide binding
INS90_02565	COG1388	LysM domain
INS90_02565	COG4942	peptidase
INS90_02605	COG0018	arginyl-trna synthetase
INS90_02610	COG0019	diaminopimelate decarboxylase activity
INS90_02615	COG0460	homoserine dehydrogenase
INS90_02620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INS90_02625	COG0083	homoserine kinase activity
INS90_02640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INS90_02645	COG2890	protein-(glutamine-N5) methyltransferase activity
INS90_02665	COG0356	it plays a direct role in the translocation of protons across the membrane
INS90_02670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS90_02675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INS90_02680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS90_02685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INS90_02690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INS90_02695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INS90_02710	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
INS90_02745	COG0366	Alpha amylase catalytic
INS90_02760	COG1175	transmembrane transport
INS90_02765	COG3833	ABC-type maltose transport systems, permease component
INS90_02780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INS90_02795	COG0366	Alpha amylase catalytic
INS90_02805	COG0577	efflux transmembrane transporter activity
INS90_02805	COG1136	(ABC) transporter
INS90_02820	COG0058	SHG alpha-glucan phosphorylase activity
INS90_02825	COG0180	Tryptophanyl-tRNA synthetase
INS90_02855	COG3480	Lon protease (S16) C-terminal proteolytic domain
INS90_02865	COG1615	UPF0182 protein
INS90_02870	COG1470	cell adhesion involved in biofilm formation
INS90_02870	COG0366	Alpha amylase catalytic
INS90_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_02885	COG1131	(ABC) transporter
INS90_02895	COG0387	Pfam Sodium calcium exchanger
INS90_02905	COG1053	succinate dehydrogenase
INS90_02925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INS90_02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INS90_02945	COG4989	oxidoreductase activity
INS90_02960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS90_02970	COG4585	Histidine kinase
INS90_02975	COG2135	peptidase activity
INS90_02980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INS90_02985	COG1404	Belongs to the peptidase S8 family
INS90_02995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS90_03000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS90_03005	COG0154	amidase activity
INS90_03010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS90_03075	COG0129	dihydroxy-acid dehydratase activity
INS90_03080	COG0569	domain protein
INS90_03080	COG2985	domain, Protein
INS90_03090	COG0440	acetolactate synthase activity
INS90_03095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INS90_03115	COG0473	3-isopropylmalate dehydrogenase activity
INS90_03120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INS90_03125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS90_03130	COG1882	Formate acetyltransferase
INS90_03135	COG1882	Formate acetyltransferase
INS90_03145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INS90_03165	COG4750	Nucleotidyl transferase
INS90_03170	COG3475	LICD family
INS90_03175	COG1216	Glycosyl transferase, family 2
INS90_03175	COG1442	glycosyl transferase family 8
INS90_03230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
INS90_03240	COG1162	GTPase activity
INS90_03270	COG1263	PTS System
INS90_03270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS90_03270	COG2190	(PTS) system
INS90_03275	COG2818	Glycosylase
INS90_03285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
INS90_03290	COG2354	Protein conserved in bacteria
INS90_03295	COG3590	peptidase
INS90_03305	COG1045	serine acetyltransferase
INS90_03315	COG1739	Uncharacterized protein family UPF0029
INS90_03350	COG0393	Putative heavy-metal-binding
INS90_03385	COG0667	Aldo Keto reductase
INS90_03390	COG0544	peptidyl-prolyl cis-trans isomerase activity
INS90_03395	COG0740	serine-type endopeptidase activity
INS90_03400	COG0740	serine-type endopeptidase activity
INS90_03405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INS90_03410	COG0287	Prephenate dehydrogenase
INS90_03410	COG1605	Chorismate mutase
INS90_03430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INS90_03450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INS90_03455	COG0285	dihydrofolate synthase activity
INS90_03465	COG0105	UTP biosynthetic process
INS90_03480	COG3069	C4-dicarboxylate transmembrane transporter activity
INS90_03510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INS90_03520	COG1837	Belongs to the UPF0109 family
INS90_03525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INS90_03535	COG0335	large ribosomal subunit rRNA binding
INS90_03540	COG0681	Belongs to the peptidase S26 family
INS90_03555	COG0792	nuclease activity
INS90_03570	COG4974	Belongs to the 'phage' integrase family
INS90_03580	COG2860	membrane
INS90_03585	COG0052	Belongs to the universal ribosomal protein uS2 family
INS90_03590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INS90_03605	COG0644	oxidoreductase
INS90_03625	COG0528	UMP kinase activity
INS90_03630	COG0233	cytoplasmic translational termination
INS90_03640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INS90_03650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INS90_03655	COG0750	zinc metalloprotease
INS90_03660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INS90_03670	COG0442	prolyl-tRNA aminoacylation
INS90_03680	COG0779	Required for maturation of 30S ribosomal subunits
INS90_03695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INS90_03700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INS90_03705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INS90_03710	COG5002	protein histidine kinase activity
INS90_03720	COG2271	Major facilitator Superfamily
INS90_03730	COG3842	ATPase activity
INS90_03760	COG1131	(ABC) transporter
INS90_03775	COG1185	polyribonucleotide nucleotidyltransferase activity
INS90_03785	COG0612	Peptidase, M16
INS90_03790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INS90_03795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INS90_03815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS90_03820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
INS90_03825	COG1674	ftsk spoiiie
INS90_03840	COG1546	Belongs to the CinA family
INS90_03840	COG1058	Belongs to the CinA family
INS90_03845	COG1396	sequence-specific DNA binding
INS90_03855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INS90_03860	COG2137	regulation of response to DNA damage stimulus
INS90_03865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INS90_03870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INS90_03875	COG2813	Specifically methylates the guanine in position
INS90_03880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INS90_03900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INS90_03905	COG0318	PFAM AMP-dependent synthetase and ligase
INS90_03910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INS90_03935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INS90_03945	COG2001	Belongs to the MraZ family
INS90_03950	COG0275	rRNA processing
INS90_03960	COG0768	penicillin binding
INS90_03965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INS90_03970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INS90_03975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INS90_03980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INS90_03990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INS90_03995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INS90_04005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INS90_04010	COG1496	oxidoreductase activity
INS90_04015	COG1799	cell septum assembly
INS90_04030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INS90_04045	COG0587	DNA-directed DNA polymerase activity
INS90_04050	COG2501	S4 domain
INS90_04065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_04070	COG1121	(ABC) transporter
INS90_04080	COG0423	glycine-tRNA ligase activity
INS90_04090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INS90_04105	COG0358	DNA primase activity
INS90_04115	COG0805	protein transport
INS90_04120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS90_04185	COG1090	epimerase
INS90_04205	COG0009	L-threonylcarbamoyladenylate synthase
INS90_04225	COG0477	Major facilitator Superfamily
INS90_04230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
INS90_04270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS90_04280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INS90_04300	COG1940	carbohydrate kinase activity
INS90_04315	COG0174	glutamine synthetase
INS90_04320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
INS90_04340	COG0174	glutamine synthetase
INS90_04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS90_04365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS90_04375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
INS90_04390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_04405	COG0545	Peptidyl-prolyl cis-trans isomerase
INS90_04420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INS90_04440	COG0205	6-phosphofructokinase activity
INS90_04445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
INS90_04450	COG2815	serine threonine protein kinase
INS90_04450	COG0515	serine threonine protein kinase
INS90_04465	COG0142	geranyltranstransferase activity
INS90_04480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INS90_04495	COG0187	DNA topoisomerase II activity
INS90_04510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS90_04555	COG0569	domain protein
INS90_04570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INS90_04575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INS90_04580	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INS90_04640	COG2197	response regulator
INS90_04645	COG1760	l-serine dehydratase
INS90_04650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INS90_04655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INS90_04665	COG0438	transferase activity, transferring glycosyl groups
INS90_04685	COG0217	transcriptional regulatory protein
INS90_04690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INS90_04695	COG0632	four-way junction helicase activity
INS90_04700	COG2255	four-way junction helicase activity
INS90_04710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS90_04715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS90_04720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INS90_04725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INS90_04735	COG1196	nuclear chromosome segregation
INS90_04745	COG0124	histidyl-tRNA synthetase
INS90_04750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INS90_04755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INS90_04775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INS90_04790	COG2409	Drug exporters of the RND superfamily
INS90_04800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INS90_04810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INS90_04815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INS90_04835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INS90_04850	COG2217	Heavy metal translocating P-type atpase
INS90_04855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INS90_04860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INS90_04865	COG0505	Belongs to the CarA family
INS90_04870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INS90_04880	COG0194	GDP metabolic process
INS90_04885	COG1758	RNA polymerase activity
INS90_04895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS90_04905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INS90_04915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INS90_04920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INS90_04925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INS90_04930	COG0140	phosphoribosyl-ATP diphosphatase activity
INS90_04935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INS90_04975	COG1216	Glycosyl transferase, family 2
INS90_05000	COG1716	ATPase activity
INS90_05010	COG1834	amidinotransferase
INS90_05030	COG2801	Transposase and inactivated derivatives
INS90_05035	COG0205	6-phosphofructokinase activity
INS90_05040	COG1160	GTP binding
INS90_05045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INS90_05055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INS90_05080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS90_05095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INS90_05100	COG0149	triose-phosphate isomerase activity
INS90_05105	COG0126	phosphoglycerate kinase activity
INS90_05110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INS90_05115	COG1481	regulation of sporulation
INS90_05130	COG0322	excinuclease ABC activity
INS90_05155	COG0556	nucleotide-excision repair
INS90_05160	COG0237	dephospho-CoA kinase activity
INS90_05170	COG0539	negative regulation of cytoplasmic translation
INS90_05175	COG2226	methyltransferase
INS90_05200	COG0469	pyruvate kinase activity
INS90_05205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INS90_05210	COG0159	tryptophan synthase activity
INS90_05215	COG0133	tryptophan synthase activity
INS90_05220	COG0134	indole-3-glycerol-phosphate synthase activity
INS90_05230	COG0107	imidazoleglycerol-phosphate synthase activity
INS90_05245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
INS90_05255	COG4122	O-methyltransferase activity
INS90_05260	COG1222	aaa ATPase
INS90_05275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INS90_05280	COG1968	undecaprenyl-diphosphatase activity
INS90_05295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_05300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INS90_05305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INS90_05305	COG0519	Catalyzes the synthesis of GMP from XMP
INS90_05310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INS90_05330	COG0587	DNA-directed DNA polymerase activity
INS90_05345	COG1881	PFAM PEBP family protein
INS90_05350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INS90_05365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_05380	COG1119	ATPase activity
INS90_05385	COG0297	glycogen (starch) synthase activity
INS90_05395	COG0560	Phosphoserine phosphatase
INS90_05395	COG3830	Belongs to the UPF0237 family
INS90_05410	COG0488	(ABC) transporter
INS90_05420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INS90_05425	COG2151	metal-sulfur cluster biosynthetic enzyme
INS90_05450	COG0719	Fe-S assembly protein
INS90_05495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INS90_05510	COG0647	UMP catabolic process
INS90_05540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_05545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_05550	COG1121	(ABC) transporter
INS90_05555	COG0803	Belongs to the bacterial solute-binding protein 9 family
INS90_05560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INS90_05575	COG1476	TRANSCRIPTIONal
INS90_05585	COG0165	Argininosuccinate lyase
INS90_05590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INS90_05595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INS90_05605	COG0137	argininosuccinate synthase activity
INS90_05615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INS90_05620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INS90_05625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
INS90_05630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INS90_05640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INS90_05645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INS90_05665	COG1902	pentaerythritol trinitrate reductase activity
INS90_05670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_05685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INS90_05690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INS90_05700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INS90_05705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INS90_05715	COG0131	Imidazoleglycerol-phosphate dehydratase
INS90_05725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INS90_05730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS90_05735	COG1381	Involved in DNA repair and RecF pathway recombination
INS90_05740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS90_05755	COG0631	protein serine/threonine phosphatase activity
INS90_05775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INS90_05790	COG0484	heat shock protein binding
INS90_05795	COG1420	regulation of RNA biosynthetic process
INS90_05815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INS90_05820	COG0481	GTPase activity
INS90_05840	COG3237	CsbD-like
INS90_05845	COG0268	Binds directly to 16S ribosomal RNA
INS90_05850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
INS90_05855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
INS90_05870	COG1555	photosystem II stabilization
INS90_05870	COG1596	polysaccharide export
INS90_05875	COG0433	COG0433 Predicted ATPase
INS90_05885	COG0495	leucyl-tRNA aminoacylation
INS90_05910	COG0813	purine-nucleoside phosphorylase activity
INS90_05915	COG1321	iron dependent repressor
INS90_05915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_05920	COG1435	thymidine kinase activity
INS90_05950	COG1121	(ABC) transporter
INS90_05955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_05975	COG0671	phosphoesterase, PA-phosphatase related
INS90_05995	COG1113	amino acid transport
INS90_06005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INS90_06005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INS90_06010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS90_06015	COG2011	ABC-type metal ion transport system permease component
INS90_06025	COG1113	amino acid transport
INS90_06035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
INS90_06040	COG0826	peptidase U32
INS90_06045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
INS90_06050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
INS90_06055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_06075	COG2962	Rard protein
INS90_06080	COG1609	Transcriptional regulator
INS90_06085	COG3250	beta-galactosidase activity
INS90_06110	COG0726	polysaccharide deacetylase
INS90_06115	COG0133	tryptophan synthase activity
INS90_06140	COG2963	transposase activity
INS90_06200	COG4824	toxin secretion phage lysis holin
INS90_06280	COG0740	serine-type endopeptidase activity
INS90_06285	COG4695	Portal protein
INS90_06355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS90_06405	COG3617	BRO family, N-terminal domain
INS90_06415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INS90_06415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INS90_06465	COG3842	ATPase activity
INS90_06490	COG0406	alpha-ribazole phosphatase activity
INS90_06495	COG0799	negative regulation of ribosome biogenesis
INS90_06505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INS90_06510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INS90_06520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INS90_06530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INS90_06535	COG1530	ribonuclease E activity
INS90_06540	COG1271	oxidase subunit
INS90_06545	COG1294	oxidase, subunit
INS90_06550	COG4988	ABC transporter
INS90_06565	COG1132	(ABC) transporter
INS90_06570	COG1132	(ABC) transporter
INS90_06595	COG0571	ribonuclease III activity
INS90_06610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INS90_06620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INS90_06625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS90_06635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INS90_06640	COG1333	cytochrome c biogenesis protein
INS90_06645	COG0785	Cytochrome C biogenesis protein
INS90_06665	COG0561	phosphatase activity
INS90_06675	COG0431	NADPH-dependent FMN reductase
INS90_06675	COG1053	succinate dehydrogenase
INS90_06675	COG3976	FMN-binding domain protein
INS90_06680	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS90_06690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INS90_06705	COG0066	3-isopropylmalate dehydratase activity
INS90_06710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INS90_06720	COG0438	transferase activity, transferring glycosyl groups
INS90_06735	COG4975	Glucose uptake
INS90_06740	COG0339	signal peptide processing
INS90_06775	COG1609	Transcriptional regulator
INS90_06800	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS90_06805	COG1022	Amp-dependent synthetase and ligase
INS90_06830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INS90_06835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INS90_06840	COG1234	tRNA 3'-trailer cleavage
INS90_06845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INS90_06855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INS90_06880	COG2985	domain, Protein
INS90_06880	COG0569	domain protein
INS90_06895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INS90_06900	COG0737	Belongs to the 5'-nucleotidase family
INS90_06905	COG0778	Nitroreductase
INS90_06980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_07025	COG1619	proteins homologs of microcin C7 resistance protein MccF
INS90_07035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INS90_07040	COG0739	heme binding
INS90_07045	COG2177	Part of the ABC transporter FtsEX involved in
INS90_07050	COG2884	Cell division ATP-binding protein ftsE
INS90_07055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INS90_07130	COG0513	Belongs to the DEAD box helicase family
INS90_07135	COG2095	MarC family integral membrane protein
INS90_07145	COG0006	proline dipeptidase activity
INS90_07150	COG2239	Acts as a magnesium transporter
INS90_07175	COG1611	Belongs to the LOG family
INS90_07185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INS90_07190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INS90_07210	COG1079	Belongs to the binding-protein-dependent transport system permease family
INS90_07215	COG4603	Belongs to the binding-protein-dependent transport system permease family
INS90_07220	COG3845	ABC transporter
INS90_07225	COG1744	ABC transporter substrate-binding protein PnrA-like
INS90_07245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INS90_07250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INS90_07260	COG1268	BioY protein
INS90_07265	COG0736	holo-[acyl-carrier-protein] synthase activity
INS90_07270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INS90_07275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INS90_07280	COG4770	biotin carboxylase activity
INS90_07300	COG0644	oxidoreductase
INS90_07305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INS90_07320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INS90_07325	COG2271	Major facilitator Superfamily
INS90_07330	COG2030	dehydratase
INS90_07360	COG0110	maltose O-acetyltransferase activity
INS90_07370	COG0039	L-malate dehydrogenase activity
INS90_07435	COG0166	Belongs to the GPI family
INS90_07440	COG0205	6-phosphofructokinase activity
INS90_07470	COG0045	succinate-CoA ligase (ADP-forming) activity
INS90_07475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INS90_07475	COG2755	lipolytic protein G-D-S-L family
INS90_07485	COG5646	InterPro IPR014922
INS90_07510	COG0857	belongs to the CobB CobQ family
INS90_07510	COG0280	phosphate acetyltransferase
INS90_07515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INS90_07535	COG0726	polysaccharide deacetylase
INS90_07545	COG1136	(ABC) transporter
INS90_07565	COG0114	fumarate hydratase activity
INS90_07590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INS90_07600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INS90_07605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INS90_07610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INS90_07615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS90_07620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INS90_07630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INS90_07645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INS90_07650	COG0733	neurotransmitter:sodium symporter activity
INS90_07660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS90_07665	COG1053	succinate dehydrogenase
INS90_07690	COG0802	atpase or kinase
INS90_07695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INS90_07705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INS90_07710	COG1072	(Pantothenic acid kinase))
INS90_07720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INS90_07725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INS90_07735	COG4720	Psort location CytoplasmicMembrane, score
INS90_07740	COG1122	ATPase activity
INS90_07745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INS90_07760	COG0101	tRNA pseudouridine synthase activity
INS90_07765	COG1940	carbohydrate kinase activity
INS90_07775	COG0765	amino acid transport
INS90_07780	COG1126	abc transporter atp-binding protein
INS90_07785	COG0640	Transcriptional regulator
INS90_07795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INS90_07805	COG0789	Transcriptional regulator
INS90_07810	COG0203	ribosomal protein L17
INS90_07815	COG0202	RNA polymerase activity
INS90_07825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INS90_07830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS90_07835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INS90_07840	COG0024	Methionine aminopeptidase
INS90_07845	COG0563	adenylate kinase activity
INS90_07855	COG0200	Binds to the 23S rRNA
INS90_07860	COG1841	ribosomal large subunit assembly
INS90_07865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INS90_07875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INS90_07880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INS90_07885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS90_07890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INS90_07895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INS90_07900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INS90_07915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INS90_07920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INS90_07925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INS90_07930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INS90_07935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INS90_07940	COG0089	rRNA binding
INS90_07945	COG0088	Forms part of the polypeptide exit tunnel
INS90_07950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INS90_07955	COG0051	transcription antitermination factor activity, RNA binding
INS90_07965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INS90_07970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INS90_07975	COG0049	tRNA binding
INS90_07980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INS90_07985	COG0833	amino acid
INS90_07990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INS90_07995	COG0085	RNA polymerase activity
INS90_08000	COG0222	ribosome binding
INS90_08005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INS90_08010	COG0572	uridine kinase
INS90_08015	COG0081	regulation of translation
INS90_08020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INS90_08040	COG0436	Aminotransferase
INS90_08050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
INS90_08065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INS90_08070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS90_08090	COG1666	GTP binding
INS90_08100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INS90_08110	COG5401	PFAM Sporulation and spore germination
INS90_08115	COG5000	phosphorelay sensor kinase activity
INS90_08115	COG5002	protein histidine kinase activity
INS90_08120	COG0745	RESPONSE REGULATOR receiver
INS90_08140	COG0714	Associated with various cellular activities
INS90_08185	COG0483	inositol monophosphate 1-phosphatase activity
INS90_08200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INS90_08205	COG0385	Bile acid
INS90_08230	COG1216	Glycosyl transferase, family 2
INS90_08230	COG0438	transferase activity, transferring glycosyl groups
INS90_08250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INS90_08275	COG0438	transferase activity, transferring glycosyl groups
INS90_08300	COG0673	inositol 2-dehydrogenase activity
INS90_08310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS90_08325	COG1088	dTDP-glucose 4,6-dehydratase activity
INS90_08345	COG1316	TRANSCRIPTIONal
INS90_08355	COG0642	Histidine kinase
INS90_08360	COG0745	RESPONSE REGULATOR receiver
INS90_08375	COG0424	maF-like protein
INS90_08410	COG1217	gtp-binding protein TYPA
INS90_08420	COG1132	(ABC) transporter
INS90_08425	COG1132	(ABC) transporter
INS90_08450	COG0321	lipoyl(octanoyl) transferase activity
INS90_08455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INS90_08465	COG1362	aminopeptidase activity
INS90_08480	COG2838	Isocitrate dehydrogenase
INS90_08485	COG2391	methyltransferase activity
INS90_08490	COG0425	Belongs to the sulfur carrier protein TusA family
INS90_08510	COG2116	formate transmembrane transporter activity
INS90_08520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INS90_08530	COG0242	peptide deformylase activity
INS90_08535	COG1970	mechanosensitive ion channel activity
INS90_08545	COG1174	glycine betaine transport
INS90_08550	COG1174	glycine betaine transport
INS90_08555	COG0517	IMP dehydrogenase activity
INS90_08555	COG1125	glycine betaine transport
INS90_08565	COG0778	Nitroreductase
INS90_08590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INS90_08590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS90_08675	COG0012	GTP binding
INS90_08685	COG1322	Protein conserved in bacteria
INS90_08690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INS90_08700	COG1570	exodeoxyribonuclease VII activity
INS90_08705	COG1722	exodeoxyribonuclease VII activity
INS90_08710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_08715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS90_08725	COG2326	polyphosphate kinase activity
INS90_08730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INS90_08735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INS90_08740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS90_08755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INS90_08760	COG1012	belongs to the aldehyde dehydrogenase family
INS90_08775	COG1131	(ABC) transporter
INS90_08780	COG2188	Transcriptional regulator
INS90_08805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS90_08825	COG0148	phosphopyruvate hydratase activity
INS90_08835	COG0193	aminoacyl-tRNA hydrolase activity
INS90_08845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INS90_08850	COG1136	(ABC) transporter
INS90_08860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS90_08885	COG4152	abc transporter atp-binding protein
INS90_08890	COG1668	transmembrane transport
INS90_08900	COG0488	(ABC) transporter
INS90_08905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INS90_08910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INS90_08920	COG0084	hydrolase, TatD family'
INS90_08925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INS90_08935	COG1335	isochorismatase
INS90_08965	COG2873	o-acetylhomoserine
INS90_08975	COG1131	(ABC) transporter
INS90_08990	COG2813	Specifically methylates the guanine in position
INS90_08995	COG0667	Aldo Keto reductase
INS90_09000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS90_09015	COG1120	ATPase activity
INS90_09020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS90_09050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
INS90_09050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS90_09055	COG1620	l-lactate permease
INS90_09060	COG0247	lactate metabolic process
INS90_09070	COG1556	Lactate utilization protein
INS90_09090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS90_09100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS90_09100	COG1263	PTS System
INS90_09115	COG1131	(ABC) transporter
INS90_09120	COG1051	belongs to the nudix hydrolase family
INS90_09130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_09135	COG3711	transcriptional antiterminator
INS90_09150	COG1511	domain protein
INS90_09160	COG2848	UPF0210 protein
INS90_09165	COG3830	Belongs to the UPF0237 family
INS90_09170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS90_09175	COG0254	rRNA binding
INS90_09180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS90_09185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS90_09190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS90_09210	COG1120	ATPase activity
INS90_09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_09220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_09225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
INS90_09235	COG2801	Transposase and inactivated derivatives
INS90_09355	COG0589	response to stress
INS90_09375	COG2252	PERMEase
INS90_09380	COG1482	cell wall glycoprotein biosynthetic process
INS90_09390	COG1278	Cold shock
INS90_09400	COG1842	Phage shock protein A
INS90_09410	COG0745	RESPONSE REGULATOR receiver
INS90_09415	COG2205	protein histidine kinase activity
INS90_09425	COG4221	oxidoreductase activity
INS90_09435	COG0459	protein refolding
INS90_09450	COG1136	(ABC) transporter
INS90_09450	COG0577	efflux transmembrane transporter activity
INS90_09460	COG1136	(ABC) transporter
INS90_09465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INS90_09475	COG0395	ABC-type sugar transport system, permease component
INS90_09480	COG1175	transmembrane transport
INS90_09500	COG1609	Transcriptional regulator
INS90_09530	COG3842	ATPase activity
INS90_09545	COG1653	transport
INS90_09550	COG1175	transmembrane transport
INS90_09575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INS90_09880	COG2233	PERMEase
INS90_09895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_09900	COG0215	cysteine-tRNA ligase activity
INS90_09910	COG1136	(ABC) transporter
INS90_09925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INS90_09930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INS90_09940	COG0745	RESPONSE REGULATOR receiver
INS90_09950	COG0704	Plays a role in the regulation of phosphate uptake
INS90_09965	COG2801	Transposase and inactivated derivatives
INS90_09985	COG0588	phosphoglycerate mutase activity
INS90_10200	COG0629	single-stranded DNA binding
INS90_10275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INS90_10280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INS90_10285	COG1754	DNA topoisomerase type I activity
INS90_10285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INS90_10300	COG3655	Transcriptional regulator
INS90_10305	COG1111	helicase
INS90_10305	COG1205	dead DEAH box helicase
INS90_10350	COG2267	carboxylic ester hydrolase activity
INS90_10380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS90_10400	COG3304	Inner membrane component domain
INS90_10410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INS90_10420	COG0315	cyclic pyranopterin monophosphate synthase activity
INS90_10430	COG0521	Mo-molybdopterin cofactor biosynthetic process
INS90_10475	COG0471	metal ion transport
INS90_10480	COG3852	Histidine kinase
INS90_10505	COG2801	Transposase and inactivated derivatives
INS90_10560	COG4868	Belongs to the UPF0371 family
INS90_10565	COG1114	Component of the transport system for branched-chain amino acids
INS90_10580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INS90_10595	COG1215	transferase activity, transferring glycosyl groups
INS90_10605	COG0077	Prephenate dehydratase
INS90_10615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INS90_10620	COG0561	phosphatase activity
INS90_10645	COG0471	metal ion transport
INS90_10685	COG1518	maintenance of DNA repeat elements
INS90_10750	COG1643	Atp-dependent helicase
INS90_10760	COG0569	domain protein
INS90_10765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS90_10785	COG0343	queuine tRNA-ribosyltransferase activity
INS90_10795	COG1428	Deoxynucleoside kinase
INS90_10840	COG0351	phosphomethylpyrimidine kinase
INS90_10855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INS90_10860	COG0084	hydrolase, TatD family'
INS90_10870	COG0305	Participates in initiation and elongation during chromosome replication
INS90_10890	COG0359	binds to the 23S rRNA
INS90_10895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INS90_10905	COG0360	Binds together with S18 to 16S ribosomal RNA
INS90_10910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS90_10915	COG0628	permease
INS90_10945	COG0492	ferredoxin-NADP+ reductase activity
INS90_10950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_10955	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS90_10970	COG0357	Ribosomal RNA small subunit methyltransferase G
INS90_10980	COG0706	membrane insertase activity
INS90_10985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INS90_10990	COG0594	ribonuclease P activity
INS90_10995	COG0230	Belongs to the bacterial ribosomal protein bL34 family