locus-tag class description Tpau_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Tpau_0003 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Tpau_0005 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tpau_0007 ENOG4105C57 major facilitator superfamily Tpau_0008 ENOG4105K7N UPF0232 protein Tpau_0009 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tpau_0010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tpau_0015 ENOG4105C37 (CBS) domain Tpau_0016 ENOG4105C37 (CBS) domain Tpau_0027 ENOG4105D9P serine threonine protein kinase Tpau_0028 ENOG4107TPY serine threonine protein kinase Tpau_0029 ENOG4105CJN penicillin-binding protein Tpau_0032 ENOG4105HZM Fha domain containing protein Tpau_0033 ENOG4105TV9 FHA Domain-Containing protein Tpau_0037 ENOG4107QNK )-transporter Tpau_0041 ENOG4105CPQ Dehydrogenase Tpau_0045 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Tpau_0048 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 Tpau_0052 ENOG4105D3Q Sugar transferase Tpau_0053 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Tpau_0055 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Tpau_0058 ENOG4107T8Q Glycosyl transferase (Group 1 Tpau_0060 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tpau_0068 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Tpau_0071 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tpau_0074 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Tpau_0079 ENOG4105CYP glycoside hydrolase, family Tpau_0087 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Tpau_0093 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tpau_0094 ENOG4105EB3 Histidine kinase Tpau_0095 ENOG4107B2H carbonic anhydrase Tpau_0097 ENOG4108KXV response regulator Tpau_0098 ENOG4105BZU Histidine kinase Tpau_0100 ENOG4105DIM ABC transporter Tpau_0101 ENOG4105CIG ABC transporter Tpau_0105 ENOG4105CEP NADH dehydrogenase Tpau_0107 ENOG4105CBC glutamate synthase Tpau_0112 ENOG410848D S4 domain protein YaaA Tpau_0114 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Tpau_0115 ENOG4105C26 Dehydrogenase Tpau_0136 ENOG4108KGH TRANSCRIPTIONal Tpau_0138 ENOG4105C7N Xanthine uracil vitamin C permease Tpau_0140 ENOG4108RFG Tetr family transcriptional regulator Tpau_0141 ENOG4105C57 major facilitator superfamily Tpau_0145 ENOG4105CQC Prephenate dehydratase Tpau_0149 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Tpau_0158 ENOG410667J hydrolase Tpau_0160 ENOG4105JFG SpoIID LytB domain protein Tpau_0162 ENOG410602S Transferase Tpau_0164 ENOG4106YN8 Prenyltransferase Tpau_0165 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids Tpau_0167 ENOG4105BZU Histidine kinase Tpau_0172 ENOG4105DWY Agmatine deiminase Tpau_0173 ENOG4108M8W Monooxygenase Tpau_0176 ENOG4105D8K carboxyl transferase Tpau_0177 ENOG4105CQB FAD linked oxidase domain protein Tpau_0178 ENOG4108ZGC gaf domain protein Tpau_0183 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Tpau_0184 ENOG410804X Transcriptional regulator Tpau_0185 ENOG4105DE4 1-phosphofructokinase Tpau_0186 ENOG4105DM4 PTS System Tpau_0189 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Tpau_0191 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Tpau_0192 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Tpau_0195 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Tpau_0198 ENOG4105KXX peptidase s58 dmpa Tpau_0200 ENOG4105K56 Transcriptional regulator Tpau_0208 ENOG4105DZ2 Transcriptional regulator Tpau_0211 ENOG4105WBV Transcriptional regulator Tpau_0212 ENOG4108QER Adenylate cyclase Tpau_0213 ENOG4105EJQ L-serine dehydratase Tpau_0214 ENOG4108TIT dATP pyrophosphohydrolase Tpau_0215 ENOG4105T0Z Conserved Protein Tpau_0216 ENOG4105MZU cell filamentation protein Tpau_0219 ENOG4105MZU cell filamentation protein Tpau_0224 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein Tpau_0229 ENOG4105E6M Sulphatase-modifying factor protein Tpau_0238 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 Tpau_0239 ENOG4105VG9 Plasmid stabilization system Tpau_0246 ENOG4105CJA serine threonine protein kinase Tpau_0274 ENOG4107SVN transposase Tpau_0280 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_0284 ENOG4105C7K acetolactate synthase Tpau_0294 ENOG4105D5G Transposase Tpau_0323 ENOG4105D5G Transposase Tpau_0333 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin Tpau_0341 ENOG4105CHU acetyl-coa acetyltransferase Tpau_0346 ENOG4105C9K Endothelin-converting enzyme 1 Tpau_0351 ENOG4105BZU Histidine kinase Tpau_0354 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_0356 ENOG4108IJ0 Aspartate ammonia-lyase Tpau_0359 ENOG4105EJ2 Transcriptional regulator Tpau_0364 ENOG4108I9W Membrane Tpau_0366 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Tpau_0367 ENOG41064B9 (LipO)protein Tpau_0372 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Tpau_0373 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Tpau_0376 ENOG4105KME endoribonuclease L-psp Tpau_0380 ENOG4105CH2 amidohydrolase Tpau_0382 ENOG4105DND Transcriptional regulator Tpau_0386 ENOG4105C26 Dehydrogenase Tpau_0388 ENOG41066YJ Beta-lactamase Tpau_0389 ENOG4105CHR reductase Tpau_0396 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tpau_0401 ENOG4108M6P methyltransferase Tpau_0418 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Tpau_0423 ENOG4105D17 glycoside hydrolase, family 3 domain protein Tpau_0424 ENOG4107Z3H Transcriptional regulator, TetR family Tpau_0427 ENOG4105CHR reductase Tpau_0428 ENOG4105CHU acetyl-coa acetyltransferase Tpau_0429 ENOG4105K4P CoA-binding domain protein Tpau_0434 ENOG4105CSU acyl-Coa dehydrogenase Tpau_0438 ENOG4105C57 major facilitator superfamily Tpau_0444 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_0446 ENOG4105CSV Glutaminase Tpau_0447 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tpau_0449 ENOG4105CH6 catalase Tpau_0450 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Tpau_0456 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_0458 ENOG4105C85 amino acid Tpau_0459 ENOG4105DHP deoxycytidine triphosphate deaminase Tpau_0465 ENOG4105DF6 Fe-S oxidoreductase Tpau_0470 ENOG4105CGK Exodeoxyribonuclease III Tpau_0482 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Tpau_0483 ENOG4107S1Q Phosphatase Tpau_0486 ENOG4105CFG Acts as a chaperone (By similarity) Tpau_0487 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Tpau_0488 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tpau_0489 ENOG4105KNI merR family transcriptional Regulator Tpau_0494 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tpau_0495 ENOG4105D74 hydrolase Tpau_0498 ENOG4105DCT glycerol dehydrogenase Tpau_0500 ENOG4105VG5 Membrane Tpau_0504 ENOG4105C2N RNA methyltransferase TrmH family group 3 Tpau_0507 ENOG4105C5H ABC transporter Tpau_0508 ENOG4105DQR SNARE associated Golgi Tpau_0509 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Tpau_0517 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Tpau_0520 ENOG4105F44 Two component transcriptional regulator, winged helix family Tpau_0521 ENOG4106F60 Histidine kinase Tpau_0522 ENOG4108UQS dipeptidase Tpau_0523 ENOG4105CPF Cell wall formation (By similarity) Tpau_0527 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Tpau_0543 ENOG4105E0Y RtcB Protein Tpau_0550 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_0553 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family Tpau_0555 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Tpau_0556 ENOG4108UGV hypoxanthine phosphoribosyltransferase Tpau_0559 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Tpau_0560 ENOG4105EUJ GTP cyclohydrolase i Tpau_0561 ENOG4105EEI dihydropteroate synthase Tpau_0567 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Tpau_0568 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tpau_0569 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Tpau_0571 ENOG4105DK7 lysyl-tRNA synthetase Tpau_0573 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tpau_0576 ENOG4105MXW flavin reductase domain protein, FMN-binding Tpau_0580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tpau_0582 ENOG4105EMU Dehydrogenase Tpau_0583 ENOG4105H3G oxidoreductase Tpau_0587 ENOG4105EV9 Alpha Beta Hydrolase Tpau_0588 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Tpau_0589 ENOG4105PDP Short chain dehydrogenase Tpau_0593 ENOG4105CHR reductase Tpau_0596 ENOG4108V9Q carbonic anhydrase Tpau_0598 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Tpau_0599 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Tpau_0602 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Tpau_0603 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Tpau_0605 ENOG4105C8N cysteinyl-tRNA synthetase Tpau_0606 ENOG4105C2N RNA methyltransferase TrmH family group 3 Tpau_0608 ENOG4105E7W lamb ycsf family protein Tpau_0609 ENOG4105CC5 ABC transporter Tpau_0610 ENOG4105FDK ABC transporter Tpau_0616 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha Tpau_0617 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Tpau_0618 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Tpau_0619 ENOG4105CHU acetyl-coa acetyltransferase Tpau_0621 ENOG4107QNJ CoA-transferase subunit B Tpau_0622 ENOG4107HP6 Transcriptional regulator Tpau_0623 ENOG4108SC4 )-transporter Tpau_0624 ENOG4105EUB pirin domain protein Tpau_0626 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) Tpau_0627 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tpau_0629 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_0631 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Tpau_0634 ENOG4105CBP Major Facilitator Tpau_0635 ENOG4105CPC Aldo Keto reductase Tpau_0639 ENOG4105DKW ABC transporter Tpau_0640 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Tpau_0641 ENOG4107RSM transcriptional regulator Tpau_0642 ENOG4105D94 Major Facilitator Superfamily Tpau_0643 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_0646 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tpau_0647 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_0649 ENOG4106T4V Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Tpau_0651 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tpau_0653 ENOG4105BZU Histidine kinase Tpau_0660 ENOG4105II7 pyrroline-5-carboxylate reductase Tpau_0665 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Tpau_0667 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Tpau_0668 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Tpau_0675 ENOG41080ZE Adenylate cyclase Tpau_0676 ENOG4107R13 MMPL domain protein Tpau_0679 ENOG4105D5Q Arginine ornithine antiporter Tpau_0680 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Tpau_0681 ENOG4105DWY Agmatine deiminase Tpau_0684 ENOG4105EBR Carboxylesterase Tpau_0687 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tpau_0688 ENOG4108RH7 phosphoglycerate mutase Tpau_0690 ENOG4107QIV Cytochrome c biogenesis protein Tpau_0692 ENOG4105CRE cytochrome C Tpau_0697 ENOG41081R7 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Tpau_0702 ENOG4105CSU acyl-Coa dehydrogenase Tpau_0719 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Tpau_0720 ENOG4107TCW O-succinylbenzoate synthase Tpau_0724 ENOG4105EYF MMPL domain protein Tpau_0725 ENOG4105XTG Pfam:DUF156 Tpau_0726 ENOG4105EG6 Saccharopine dehydrogenase Tpau_0729 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Tpau_0732 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tpau_0734 ENOG4105D0M Protease HtpX homolog Tpau_0736 ENOG4108VPT UPF0234 protein Tpau_0738 ENOG410900P UPF0336 protein Tpau_0739 ENOG4108F01 MaoC domain protein Tpau_0742 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Tpau_0743 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Tpau_0750 ENOG4108VZM 50s ribosomal protein L10 Tpau_0751 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Tpau_0753 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tpau_0754 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tpau_0760 ENOG4105DIA mandelate racemase muconate lactonizing Tpau_0761 ENOG4105CHR reductase Tpau_0763 ENOG4105JXH GntR family transcriptional regulator Tpau_0770 ENOG4105C0D helicase Tpau_0775 ENOG4105CHU acetyl-coa acetyltransferase Tpau_0778 ENOG4105ENX hydrolase Tpau_0779 ENOG4105CMT Dihydroxyacetone kinase Tpau_0784 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tpau_0786 ENOG4105F8J Adenylate Guanylate cyclase Tpau_0788 ENOG4105NPE arsR family transcriptional regulator Tpau_0790 ENOG4105DRP amino acid AbC transporter Tpau_0791 ENOG4105CDA abc transporter atp-binding protein Tpau_0793 ENOG4105JAB phenazine biosynthesis protein, phzf family Tpau_0794 ENOG4105CE4 GlcNAc 6-P deacetylase Tpau_0797 ENOG4105C5Y PTS System Tpau_0800 ENOG4105EA8 2-Nitropropane dioxygenase Tpau_0801 ENOG4105FDP GntR family transcriptional regulator Tpau_0809 ENOG4105CFI type iii restriction protein res subunit Tpau_0814 ENOG4105CHP RNA polymerase Tpau_0817 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tpau_0818 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tpau_0820 ENOG41087PP glycosyltransferase MGT family Tpau_0823 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tpau_0825 ENOG4105VEQ Cold shock protein Tpau_0828 ENOG4108N0W Major Facilitator superfamily Tpau_0837 ENOG4105CSW GntR family transcriptional regulator Tpau_0839 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) Tpau_0841 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tpau_0842 ENOG4105C26 Dehydrogenase Tpau_0843 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Tpau_0844 ENOG4107SFI Major Facilitator superfamily Tpau_0847 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Tpau_0849 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Tpau_0850 ENOG4105EV4 Multidrug resistance protein mdtH Tpau_0851 ENOG4105PDP Short chain dehydrogenase Tpau_0856 ENOG41081K0 peptidylprolyl cis-trans isomerase Tpau_0861 ENOG4105CV8 reductase Tpau_0863 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin Tpau_0865 ENOG4105EC2 ftsk spoIIIe Tpau_0867 ENOG4107SVN transposase Tpau_0869 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Tpau_0870 ENOG4108UJD 30S ribosomal protein S9 Tpau_0871 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Tpau_0872 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Tpau_0878 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tpau_0882 ENOG4105KZX Pterin carbinolamine dehydratase Tpau_0885 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tpau_0889 ENOG4105E7U AraC family transcriptional regulator Tpau_0896 ENOG4107SVN transposase Tpau_0899 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tpau_0900 ENOG4105DYW oxidoreductase Tpau_0901 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tpau_0905 ENOG4108VT4 Tpau_0907 ENOG4107QVP Dehydrogenase Tpau_0910 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tpau_0915 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_0916 ENOG4105D9P serine threonine protein kinase Tpau_0918 ENOG4108IQI permease Tpau_0931 ENOG4105KK4 UPF0060 membrane protein Tpau_0937 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Tpau_0939 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Tpau_0941 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tpau_0944 ENOG4105DWV Homoserine O-trans-acetylase Tpau_0945 ENOG4105F27 Major Facilitator Tpau_0948 ENOG4105CGK Exodeoxyribonuclease III Tpau_0949 ENOG4105C31 Tryptophanyl-tRNA synthetase Tpau_0951 ENOG4105D5Q Arginine ornithine antiporter Tpau_0952 ENOG4105DZ1 carboxypeptidase Tpau_0964 ENOG4105E33 succinate dehydrogenase Tpau_0965 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Tpau_0970 ENOG4105C5I Dehydrogenase Tpau_0972 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_0975 ENOG4108AHD Transcriptional regulator Tpau_0976 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Tpau_0982 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Tpau_0986 ENOG4107RM1 amidohydrolase Tpau_0990 ENOG4108KPJ rna polymerase sigma factor Tpau_0992 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tpau_0995 ENOG4105MVE transcriptional regulator Tpau_0998 ENOG4105CNT hydrolase family 2 Tpau_0999 ENOG4105I1K ABC transporter Tpau_1000 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Tpau_1002 ENOG4108IJ9 (ABC) transporter Tpau_1005 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Tpau_1006 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Tpau_1009 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_1011 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_1014 ENOG4107QRT dEAD DEAH box helicase Tpau_1015 ENOG4105EBR Carboxylesterase Tpau_1017 ENOG4105CSU acyl-Coa dehydrogenase Tpau_1020 ENOG4108YYH Nadph-dependent fmn reductase Tpau_1022 ENOG4105M0C cytoplasmic protein Tpau_1027 ENOG4105KME endoribonuclease L-psp Tpau_1031 ENOG4108JIK carboxylase Tpau_1041 ENOG4107WR6 Maf-like protein Tpau_1043 ENOG4105D8K carboxyl transferase Tpau_1044 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Tpau_1046 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tpau_1047 ENOG41065SU Two-component system sensor kinase Tpau_1049 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Tpau_1053 ENOG4107U32 Beta-lactamase domain protein Tpau_1061 ENOG4107TB5 TRANSCRIPTIONal Tpau_1062 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Tpau_1066 ENOG4107ZBN O-methyltransferase Tpau_1067 ENOG4105DU6 RNA polymerase Tpau_1068 ENOG4106684 Tpau_1069 ENOG4105C0H protease Tpau_1070 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Tpau_1076 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tpau_1077 ENOG4105BZU Histidine kinase Tpau_1078 ENOG4108MKR lipoprotein lpqb Tpau_1080 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Tpau_1081 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tpau_1082 ENOG4105E9Q Acyl-transferase Tpau_1095 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Tpau_1096 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Tpau_1097 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Tpau_1099 ENOG4108Z4X TRANSCRIPTIONal Tpau_1100 ENOG4108RAV Conserved protein Tpau_1103 ENOG4105C26 Dehydrogenase Tpau_1104 ENOG4105PDP Short chain dehydrogenase Tpau_1105 ENOG4108Z66 YbaK ebsC protein Tpau_1107 ENOG4105EMN RNA polymerase sigma factor Tpau_1111 ENOG4107TE5 Lipid kinase Tpau_1113 ENOG4108ZM9 phosphoglycerate mutase Tpau_1114 ENOG4107QJE Chromosome Partitioning Protein Tpau_1118 ENOG4105C1J atp-dependent rna helicase Tpau_1124 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_1130 ENOG4108YIQ Alpha beta hydrolase Tpau_1132 ENOG4105C4R Atp-dependent dna helicase Tpau_1134 ENOG4105F9F transposase Tpau_1138 ENOG4107SVH Potassium channel protein Tpau_1139 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_1142 ENOG41067SE Tetr family transcriptional regulator Tpau_1145 ENOG4107USK Extracellular solute-binding protein, family 5 Tpau_1146 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tpau_1148 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Tpau_1150 ENOG4105D9N nucleoside Tpau_1151 ENOG4108Z4U Ferredoxin Tpau_1153 ENOG4105E18 UPF0276 protein Tpau_1159 ENOG4105CJW magnesium transporter Tpau_1160 ENOG4107R4C succinyl-diaminopimelate desuccinylase Tpau_1161 ENOG4108URH decarboxylase Tpau_1162 ENOG4108URH decarboxylase Tpau_1164 ENOG4105EEI dihydropteroate synthase Tpau_1165 ENOG4105C3Q Glycosyl transferase, family 2 Tpau_1174 ENOG4107QPH glycogen) synthase Tpau_1175 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Tpau_1177 ENOG4105N14 lysine exporter protein LysE YggA Tpau_1180 ENOG4105E1F short-chain dehydrogenase reductase Tpau_1183 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase Tpau_1184 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tpau_1187 ENOG4107QKV phosphomannomutase Tpau_1189 ENOG4105EIP mannose-6-phosphate isomerase Tpau_1191 ENOG4105CUB amino acid Tpau_1192 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Tpau_1195 ENOG4105CJW magnesium transporter Tpau_1207 ENOG4105D7N magnesium and cobalt transport protein CorA Tpau_1211 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Tpau_1215 ENOG4105C0D helicase Tpau_1220 ENOG4107RDB Major Facilitator Tpau_1222 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Tpau_1228 ENOG4105C75 arginyL-tRNA synthetase Tpau_1230 ENOG4105D6E homoserine dehydrogenase Tpau_1231 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tpau_1232 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Tpau_1235 ENOG4105VFB Binds the 23S rRNA (By similarity) Tpau_1236 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Tpau_1237 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tpau_1247 ENOG4105ESV Glycosyl transferase, family 4 Tpau_1249 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) Tpau_1250 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tpau_1252 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tpau_1253 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Tpau_1254 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Tpau_1255 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Tpau_1256 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tpau_1259 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tpau_1261 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) Tpau_1265 ENOG4105CHU acetyl-coa acetyltransferase Tpau_1271 ENOG4105DRS transport system, permease Tpau_1273 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_1278 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Tpau_1279 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Tpau_1281 ENOG4105DND Transcriptional regulator Tpau_1285 ENOG4108RWI nicotinamidase Tpau_1286 ENOG4107RKP Nicotinate phosphoribosyltransferase Tpau_1287 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Tpau_1294 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Tpau_1295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Tpau_1296 ENOG4107TB5 TRANSCRIPTIONal Tpau_1297 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tpau_1310 ENOG4105F9E Shikimate 5-dehydrogenase Tpau_1315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Tpau_1316 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Tpau_1317 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Tpau_1321 ENOG4105C1G acyl-Coa dehydrogenase Tpau_1324 ENOG4105DND Transcriptional regulator Tpau_1329 ENOG4105C1G acyl-Coa dehydrogenase Tpau_1330 ENOG410905X membrane-flanked domain protein Tpau_1331 ENOG4105CKV Membrane Tpau_1334 ENOG4105CK7 Sodium proline symporter Tpau_1336 ENOG4105DVE abc transporter atp-binding protein Tpau_1339 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Tpau_1340 ENOG4105D7A ATP-binding protein Tpau_1341 ENOG4105E1F short-chain dehydrogenase reductase Tpau_1342 ENOG4105MGM doxx family Tpau_1344 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tpau_1349 ENOG4105D4T Citrate transporter Tpau_1350 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Tpau_1351 ENOG4108V9W transcriptional regulatory protein Tpau_1357 ENOG4107RJ5 oxidoreductase Tpau_1359 ENOG4105CNN ABC, transporter Tpau_1360 ENOG4105C2J ABC transporter Tpau_1362 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Tpau_1364 ENOG4105FDP GntR family transcriptional regulator Tpau_1365 ENOG4105D7K pfkb domain protein Tpau_1367 ENOG4105C26 Dehydrogenase Tpau_1368 ENOG4105DH8 myo-inositol catabolism Tpau_1369 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Tpau_1371 ENOG4105FBW Monooxygenase Tpau_1379 ENOG4107QZF nitrite reductase NADPH large subunit Tpau_1380 ENOG4107QZF nitrite reductase NADPH large subunit Tpau_1381 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tpau_1382 ENOG4108JA1 polyketide synthase Tpau_1385 ENOG4105C7I Dehydrogenase Tpau_1386 ENOG4108TGP Thioesterase superfamily protein Tpau_1390 ENOG4105CG3 alpha amylase, catalytic region Tpau_1395 ENOG4109057 Tpau_1396 ENOG4105K5B UPF0225 protein Tpau_1399 ENOG4105MC2 DSBA oxidoreductase Tpau_1400 ENOG4108K0D peptidase, M48 Tpau_1410 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_1416 ENOG4105CUB amino acid Tpau_1419 ENOG4105E39 Enoyl-CoA hydratase Tpau_1423 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tpau_1441 ENOG4108VGI doxx family Tpau_1443 ENOG4105C0X amino acid Tpau_1447 ENOG4107RPH Isocitrate lyase Tpau_1448 ENOG4108387 Peptidase E Tpau_1450 ENOG4105EHG Permease protein Tpau_1451 ENOG4105E0A ABC, transporter Tpau_1453 ENOG4108JCI Transcriptional regulator Tpau_1454 ENOG4105DKK Benzoate Tpau_1460 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Tpau_1461 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tpau_1462 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tpau_1463 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Tpau_1465 ENOG4105C5H ABC transporter Tpau_1468 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tpau_1469 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Tpau_1471 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Tpau_1472 ENOG4105C03 ribonuclease Tpau_1473 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Tpau_1474 ENOG4105K46 50S ribosomal protein l27 Tpau_1475 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tpau_1476 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Tpau_1477 ENOG4105URP P-aminobenzoate N-oxygenase AurF Tpau_1478 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tpau_1479 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tpau_1489 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) Tpau_1493 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Tpau_1494 ENOG4105C4K Nad synthetase Tpau_1497 ENOG4105C5F glutamine synthetase Tpau_1498 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Tpau_1501 ENOG4108V1T peptidylprolyl cis-trans isomerase Tpau_1506 ENOG4105EBR Carboxylesterase Tpau_1510 ENOG4105C5F glutamine synthetase Tpau_1513 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Tpau_1514 ENOG4108RWP Major Facilitator Superfamily protein Tpau_1515 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Tpau_1518 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Tpau_1523 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tpau_1524 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tpau_1526 ENOG41080Z7 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Tpau_1534 ENOG4108Z6Z Transcriptional regulator Tpau_1537 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Tpau_1538 ENOG4108ZRS Part of cytochrome c oxidase, its function is Tpau_1540 ENOG4105F9F transposase Tpau_1544 ENOG4105C5I Dehydrogenase Tpau_1546 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tpau_1547 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Tpau_1555 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) Tpau_1557 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase Tpau_1559 ENOG4108RVA ribokinase Tpau_1563 ENOG4106H78 methyltransferase Tpau_1564 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Tpau_1565 ENOG41087HT growth Tpau_1567 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Tpau_1568 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Tpau_1571 ENOG4108375 Acylphosphatase (EC 3.6.1.7) Tpau_1573 ENOG4106032 Glutathionylspermidine synthase Tpau_1574 ENOG4105P3N Membrane Tpau_1576 ENOG410609C Acyl carrier protein Tpau_1577 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tpau_1579 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tpau_1580 ENOG4107TYR Glycosyl Transferase Tpau_1587 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Tpau_1589 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Tpau_1593 ENOG4105EIG urea carboxylase-associated protein 1 Tpau_1594 ENOG4107R7A Allophanate hydrolase subunit 2 Tpau_1596 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Tpau_1598 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_1600 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Tpau_1610 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Tpau_1616 ENOG4105CVK Glutamate decarboxylase Tpau_1617 ENOG4105K5M 30s ribosomal protein S16 Tpau_1619 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Tpau_1620 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Tpau_1622 ENOG4105ETX regulatoR Tpau_1630 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Tpau_1632 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tpau_1636 ENOG4108IJ9 (ABC) transporter Tpau_1637 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Tpau_1638 ENOG4105DRS transport system, permease Tpau_1641 ENOG41080R2 UPF0102 protein Tpau_1642 ENOG4105C0P Mg chelatase subunit ChlI Tpau_1649 ENOG4105CSH Transporter Tpau_1651 ENOG4105D01 (LipO)protein Tpau_1652 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tpau_1653 ENOG4108UMI ABC transporter, permease Tpau_1654 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tpau_1658 ENOG4105D0M Protease HtpX homolog Tpau_1659 ENOG4105C2C drug resistance transporter, Bcr CflA Tpau_1663 ENOG4105EBR Carboxylesterase Tpau_1668 ENOG4105CE9 30S ribosomal protein S2 Tpau_1669 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Tpau_1674 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Tpau_1678 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Tpau_1682 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Tpau_1683 ENOG4105DZP Membrane-associated zinc metalloprotease Tpau_1684 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Tpau_1690 ENOG4105CJN penicillin-binding protein Tpau_1693 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tpau_1694 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Tpau_1698 ENOG4105DWT malate dehydrogenase (quinone) Tpau_1703 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tpau_1706 ENOG4107XFJ UPF0246 protein Tpau_1707 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Tpau_1712 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) Tpau_1715 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tpau_1717 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Tpau_1718 ENOG4105SFS phosphoesterase RecJ domain protein Tpau_1721 ENOG4107SCA Formamidase (EC 3.5.1.49) Tpau_1727 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Tpau_1729 ENOG4105BZN citrate synthase Tpau_1732 ENOG4107R5H iron (metal) dependent repressor, dtxr family Tpau_1734 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Tpau_1735 ENOG4105DGI Alkaline phosphatase Tpau_1737 ENOG4105CRK lysyL-tRNA synthetase Tpau_1738 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Tpau_1739 ENOG4105C1V Peptidase, M16 Tpau_1741 ENOG4105C85 amino acid Tpau_1743 ENOG4105DCF alanine dehydrogenase Tpau_1744 ENOG4105F7P transcriptional regulator AsnC family Tpau_1746 ENOG4105EFZ amidohydrolase Tpau_1749 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) Tpau_1751 ENOG4107R13 MMPL domain protein Tpau_1752 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Tpau_1760 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Tpau_1762 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tpau_1763 ENOG4105CN5 Metallo-Beta-Lactamase Tpau_1773 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tpau_1776 ENOG4105CEV competence damage-inducible protein Tpau_1777 ENOG4105WBV Transcriptional regulator Tpau_1783 ENOG4105J1Z Arabinosyltransferase Tpau_1785 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tpau_1786 ENOG4105KC9 Modulates RecA activity (By similarity) Tpau_1788 ENOG4105DRP amino acid AbC transporter Tpau_1789 ENOG4108Q1T ABC transporter Tpau_1790 ENOG4107UBR Extracellular solute-binding protein family 3 Tpau_1791 ENOG4105CDA abc transporter atp-binding protein Tpau_1793 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tpau_1796 ENOG4105C99 atpase involved in dna repair Tpau_1798 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Tpau_1799 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Tpau_1800 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Tpau_1802 ENOG4105C5Q Transcriptional regulator Tpau_1806 ENOG4105CC9 acyl-Coa dehydrogenase Tpau_1807 ENOG4105C1G acyl-Coa dehydrogenase Tpau_1808 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Tpau_1810 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Tpau_1811 ENOG4105CQ7 ATP-dependent helicase Tpau_1812 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tpau_1814 ENOG4107QN1 sodium solute Tpau_1816 ENOG4105C5Q Transcriptional regulator Tpau_1832 ENOG4105DGU Histone deacetylase Tpau_1833 ENOG4105CMV Succinyl-CoA synthetase subunit beta Tpau_1842 ENOG4105F9F transposase Tpau_1845 ENOG4105C9K Endothelin-converting enzyme 1 Tpau_1846 ENOG4107FQ9 ethanolamine ammonia-lyase Tpau_1847 ENOG4105CPD ethanolamine ammonia-lyase Tpau_1848 ENOG4105CUB amino acid Tpau_1853 ENOG4105CHR reductase Tpau_1856 ENOG4105PAD Hydrolase Tpau_1857 ENOG4105CHR reductase Tpau_1861 ENOG4105D2B acyl-CoA dehydrogenase Tpau_1862 ENOG4105C1G acyl-Coa dehydrogenase Tpau_1864 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_1865 ENOG4105CSH Transporter Tpau_1868 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein Tpau_1872 ENOG4108JIK carboxylase Tpau_1875 ENOG4105ENE Histidine kinase Tpau_1876 ENOG4105IIP Membrane Tpau_1884 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Tpau_1888 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tpau_1889 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tpau_1892 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Tpau_1894 ENOG4107JTW chlorite dismutase Tpau_1895 ENOG4105E0X reductase Tpau_1898 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Tpau_1900 ENOG4105VPX protein, conserved in bacteria Tpau_1906 ENOG4105D8K carboxyl transferase Tpau_1907 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tpau_1908 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Tpau_1910 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase Tpau_1913 ENOG4105K64 Glycosyl transferase, family 2 Tpau_1914 ENOG4107Z3H Transcriptional regulator, TetR family Tpau_1919 ENOG4105C22 threonyL-tRNA synthetase Tpau_1922 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Tpau_1923 ENOG4105E2K Glycosyl transferase (Group 1 Tpau_1924 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Tpau_1926 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Tpau_1929 ENOG4105C29 acyl-CoA thioesterase Tpau_1930 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Tpau_1932 ENOG4105CDY transcriptional regulatory protein Tpau_1934 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Tpau_1935 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Tpau_1936 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tpau_1938 ENOG4105EDW glycosyl transferase, family 39 Tpau_1940 ENOG4105C9U ATP-dependent DNA helicase RecQ Tpau_1943 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tpau_1944 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Tpau_1945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tpau_1947 ENOG4105F9F transposase Tpau_1950 ENOG4105CUT histidyl-tRNA synthetase Tpau_1953 ENOG41082BM Transcriptional regulator, arsr family Tpau_1955 ENOG4105CKI cobalamin synthesis protein Tpau_1963 ENOG4105C9M aspartyl-trna synthetase Tpau_1967 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Tpau_1969 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tpau_1975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Tpau_1976 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Tpau_1977 ENOG4105HHA aminodeoxychorismate lyase Tpau_1978 ENOG4105E2X shikimate dehydrogenase Tpau_1981 ENOG4105CPU Monooxygenase Tpau_1982 ENOG4105DEN Luciferase family Tpau_1983 ENOG4105CPU Monooxygenase Tpau_1987 ENOG4105CDA abc transporter atp-binding protein Tpau_1988 ENOG4105E5Q amino acid AbC transporter Tpau_1989 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_1990 ENOG4105BZU Histidine kinase Tpau_1994 ENOG4105DEN Luciferase family Tpau_1995 ENOG4105DYW oxidoreductase Tpau_1999 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Tpau_2000 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Tpau_2001 ENOG4105YVM Phosphoesterase, PA-phosphatase related Tpau_2002 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Tpau_2005 ENOG4108UZX fmn reductase Tpau_2006 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_2010 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Tpau_2015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tpau_2016 ENOG4105BZU Histidine kinase Tpau_2023 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Tpau_2024 ENOG4105CIH Imidazole acetol-phosphate transaminase Tpau_2025 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Tpau_2027 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Tpau_2028 ENOG410633P Hydantoin racemase Tpau_2030 ENOG4105S0E allantoin catabolism protein Tpau_2032 ENOG4107HP6 Transcriptional regulator Tpau_2034 ENOG4105E39 Enoyl-CoA hydratase Tpau_2035 ENOG4105CD5 CoA-binding domain protein Tpau_2036 ENOG4105E39 Enoyl-CoA hydratase Tpau_2037 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Tpau_2039 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Tpau_2040 ENOG4108MWI inositol mono-phosphatase Tpau_2041 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Tpau_2042 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Tpau_2044 ENOG4105CRQ synthase (Component I) Tpau_2046 ENOG4105DK0 Indole-3-glycerol phosphate synthase Tpau_2047 ENOG4105RD7 BadF BadG BcrA BcrD Tpau_2048 ENOG4105C54 Major Facilitator superfamily Tpau_2049 ENOG4105FDP GntR family transcriptional regulator Tpau_2051 ENOG4105CDA abc transporter atp-binding protein Tpau_2052 ENOG4105DRP amino acid AbC transporter Tpau_2055 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Tpau_2056 ENOG4105BZU Histidine kinase Tpau_2057 ENOG4105BZU Histidine kinase Tpau_2059 ENOG4105C5H ABC transporter Tpau_2060 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Tpau_2063 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tpau_2067 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Tpau_2070 ENOG4107QKW extracellular solute-binding protein family 1 Tpau_2072 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tpau_2074 ENOG4108Q5F Tetr family transcriptional regulator Tpau_2075 ENOG4107QM5 aconitate hydratase Tpau_2077 ENOG4105ZXU NLP P60 protein Tpau_2078 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tpau_2082 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Tpau_2083 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Tpau_2095 ENOG4105EGI Transcriptional regulator Tpau_2099 ENOG4105CY5 solute-binding protein Tpau_2100 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein Tpau_2102 ENOG4108KAZ Involved in phosphonate degradation (By similarity) Tpau_2109 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tpau_2114 ENOG4105CUB amino acid Tpau_2116 ENOG4105FDT acyl-CoA dehydrogenase Tpau_2117 ENOG4105NGS secreted protein Tpau_2122 ENOG4105DU0 nucleoside hydrolase Tpau_2124 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Tpau_2125 ENOG4108NJC Tpau_2128 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Tpau_2130 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Tpau_2133 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Tpau_2134 ENOG4105DND Transcriptional regulator Tpau_2135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tpau_2140 ENOG4105C8N cysteinyl-tRNA synthetase Tpau_2145 ENOG4105CGH 5'-nucleotidase Tpau_2146 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Tpau_2149 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase Tpau_2150 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Tpau_2153 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) Tpau_2154 ENOG4105IDI abc transporter atp-binding protein Tpau_2155 ENOG4105E5F proteasome Tpau_2158 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) Tpau_2159 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tpau_2160 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tpau_2162 ENOG4105C8J )-transporter Tpau_2166 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) Tpau_2167 ENOG4108FFZ Transcriptional regulator Tpau_2168 ENOG4107TMB Transcriptional regulator Tpau_2169 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Tpau_2177 ENOG4108RG3 short-chain dehydrogenase reductase Tpau_2178 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Tpau_2183 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Tpau_2186 ENOG4105F27 Major Facilitator Tpau_2188 ENOG4108IMY Transcriptional regulator Tpau_2191 ENOG41081F0 Precorrin-8x methylmutase Tpau_2193 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tpau_2196 ENOG4105CTK cobaltochelatase, cobn subunit Tpau_2198 ENOG4105CD3 dihydroorotase Tpau_2200 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Tpau_2201 ENOG4105Q70 Tpau_2206 ENOG4105CT3 Monooxygenase Tpau_2209 ENOG4108Z0R Transferase Tpau_2211 ENOG4105C0A alcohol dehydrogenase Tpau_2216 ENOG4105JXH GntR family transcriptional regulator Tpau_2217 ENOG4105DJ2 Major Facilitator Superfamily Tpau_2219 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tpau_2225 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Tpau_2228 ENOG410846T CoA-transferase family III Tpau_2230 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Tpau_2231 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tpau_2253 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Tpau_2261 ENOG4105E9K Isocitrate dehydrogenase Tpau_2262 ENOG4105CKW Inner membrane protein yedI Tpau_2265 ENOG4107S1E Beta-lactamase Tpau_2267 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) Tpau_2270 ENOG4107SWE Methyltransferase Tpau_2271 ENOG4105D3Q Sugar transferase Tpau_2276 ENOG4105CPQ Dehydrogenase Tpau_2282 ENOG4105DMF Dehydrogenase Tpau_2287 ENOG4105DZ6 Band 7 protein Tpau_2290 ENOG4107Z3H Transcriptional regulator, TetR family Tpau_2294 ENOG4105C7H Helicase, RecD TraA family Tpau_2295 ENOG4107QKA exodeoxyribonuclease V beta Tpau_2300 ENOG4105PMW Domain of unknown function (DUF1990) Tpau_2305 ENOG4105K7K Transcriptional regulator Tpau_2317 ENOG4105C37 (CBS) domain Tpau_2320 ENOG4105DR5 peptidase Tpau_2321 ENOG4105EHG Permease protein Tpau_2322 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Tpau_2327 ENOG4105IBP Cyclic peptide transporter Tpau_2334 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tpau_2340 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Tpau_2342 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tpau_2343 ENOG4105IIU Aminopeptidase Tpau_2346 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tpau_2348 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Tpau_2349 ENOG4105D74 hydrolase Tpau_2353 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Tpau_2355 ENOG4107FW0 short-chain dehydrogenase reductase Tpau_2362 ENOG4105M2Z protein tyrosine serine phosphatase Tpau_2369 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Tpau_2370 ENOG4105CAT Cytidine monophosphate kinase Tpau_2372 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Tpau_2373 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Tpau_2376 ENOG4108YZ4 nudix hydrolase Tpau_2377 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Tpau_2382 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tpau_2385 ENOG4105DSU hydrolase Tpau_2388 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Tpau_2390 ENOG4105W49 UPF0434 protein Tpau_2393 ENOG4105CJ1 ABC, transporter Tpau_2395 ENOG4108RZE Tetr family transcriptional regulator Tpau_2396 ENOG4105CH7 arginosuccinase Tpau_2397 ENOG4105CDH Citrulline--aspartate ligase Tpau_2398 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Tpau_2399 ENOG4105DBV ornithine carbamoyltransferase Tpau_2400 ENOG4105C8Y Acetylornithine aminotransferase Tpau_2401 ENOG4105CAS nag kinase Tpau_2402 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Tpau_2403 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Tpau_2406 ENOG4107RR1 TRANSCRIPTIONal Tpau_2408 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Tpau_2409 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Tpau_2414 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_2416 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Tpau_2417 ENOG41084BS 50S ribosomal protein L35 Tpau_2423 ENOG4105C5X domain protein Tpau_2425 ENOG4105EEM helicase Tpau_2433 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Tpau_2435 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Tpau_2436 ENOG4108YRB methyltransferase Tpau_2444 ENOG4107RRE RNA-directed DNA polymerase Tpau_2449 ENOG4106178 UPF0339 protein Tpau_2451 ENOG4108Z6Z Transcriptional regulator Tpau_2452 ENOG4105HSS phospholipase C Tpau_2454 ENOG4105C57 major facilitator superfamily Tpau_2459 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tpau_2460 ENOG4105CHF Glutathione S-transferase Tpau_2471 ENOG4105D5G Transposase Tpau_2489 ENOG4105C29 acyl-CoA thioesterase Tpau_2491 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Tpau_2496 ENOG41080RH Thioredoxin Tpau_2499 ENOG4105C1G acyl-Coa dehydrogenase Tpau_2501 ENOG4105K56 Transcriptional regulator Tpau_2504 ENOG4105VG1 fes assembly suf system protein Tpau_2505 ENOG4108UNV SUF system FeS assembly protein, NifU family Tpau_2507 ENOG4105C3K feS assembly ATPase SufC Tpau_2511 ENOG4107JC6 Membrane Tpau_2512 ENOG4105CJ1 ABC, transporter Tpau_2517 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Tpau_2518 ENOG4105EJ2 Transcriptional regulator Tpau_2521 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Tpau_2523 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Tpau_2526 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) Tpau_2533 ENOG4105C1G acyl-Coa dehydrogenase Tpau_2535 ENOG4105MXB limonene-12-epoxide hydrolase Tpau_2536 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Tpau_2538 ENOG4105CP7 Triose-phosphate isomerase Tpau_2539 ENOG4105BZA Phosphoglycerate kinase Tpau_2540 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Tpau_2542 ENOG4105CIE May be required for sporulation (By similarity) Tpau_2546 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Tpau_2550 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Tpau_2552 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_2556 ENOG4105DUX Transporter Tpau_2558 ENOG4105C26 Dehydrogenase Tpau_2560 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Tpau_2561 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Tpau_2567 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Tpau_2568 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tpau_2570 ENOG4107R72 Ceramidase Tpau_2572 ENOG4108IG5 Transcriptional regulator Tpau_2573 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Tpau_2575 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Tpau_2577 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Tpau_2580 ENOG4105SKN orotidine 5''-phosphate decarboxylase Tpau_2582 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Tpau_2585 ENOG4105CXT aspartate transcarbamylase Tpau_2588 ENOG4105C09 Bile acid Tpau_2589 ENOG410803B Involved in the transcription termination process (By similarity) Tpau_2590 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Tpau_2591 ENOG4105DC7 peptidase M24 Tpau_2610 ENOG4107T8Q Glycosyl transferase (Group 1 Tpau_2612 ENOG4106CD9 glycosyl transferase group 1 Tpau_2613 ENOG4105C30 Nad-dependent epimerase dehydratase Tpau_2614 ENOG4105C0K Gdp-mannose 4,6-dehydratase Tpau_2616 ENOG4105D49 3-dehydroquinate synthase Tpau_2617 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Tpau_2618 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Tpau_2631 ENOG4105HDK L-asparaginase Tpau_2636 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Tpau_2640 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Tpau_2641 ENOG4105DFA alanine racemase domain protein Tpau_2644 ENOG4105ME9 cell division protein FtsQ Tpau_2645 ENOG4105DFU Cell wall formation (By similarity) Tpau_2646 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Tpau_2648 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Tpau_2649 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tpau_2650 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Tpau_2652 ENOG4105CJN penicillin-binding protein Tpau_2654 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Tpau_2655 ENOG4108V6E Cell division protein mraZ Tpau_2662 ENOG4105EAH synthase Tpau_2663 ENOG4108HUF Transporter Tpau_2665 ENOG4105CM4 permease protein Tpau_2666 ENOG4108IPW abc transporter atp-binding protein Tpau_2667 ENOG41090CE integral membrane protein Tpau_2668 ENOG4105KYH transcriptional regulatory protein Tpau_2671 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tpau_2672 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Tpau_2675 ENOG4105DKQ ROK family Tpau_2681 ENOG4105JNK Glycosyl transferase (Group 1 Tpau_2689 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Tpau_2690 ENOG4108I0Q anthranilate phosphoribosyltransferase Tpau_2697 ENOG4105F9F transposase Tpau_2700 ENOG4107S8C mandelate racemase muconate lactonizing Tpau_2702 ENOG4107EFR Flavocytochrome c Tpau_2704 ENOG4105ERH Fumarylacetoacetate hydrolase Tpau_2710 ENOG4105CVJ phosphoglycerate mutase Tpau_2712 ENOG4105EGD dinuclear metal center protein, YbgI family Tpau_2722 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Tpau_2725 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Tpau_2737 ENOG4105DFA alanine racemase domain protein Tpau_2739 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Tpau_2741 ENOG4105VEQ Cold shock protein Tpau_2743 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Tpau_2748 ENOG4105VCQ rubredoxin Tpau_2749 ENOG41084UD rubredoxin Tpau_2750 ENOG4105EEF Alkane 1-monooxygenase Tpau_2751 ENOG4105K56 Transcriptional regulator Tpau_2752 ENOG4108ZHJ Organic hydroperoxide resistance protein Tpau_2753 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Tpau_2756 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tpau_2757 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Tpau_2761 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Tpau_2765 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tpau_2766 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Tpau_2772 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Tpau_2776 ENOG4105HHS UPF0256 protein Tpau_2777 ENOG4108IJ6 ABC transporter Tpau_2778 ENOG4105ECW sulfate abc transporter Tpau_2779 ENOG4108I5D sulfate abc transporter Tpau_2780 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Tpau_2783 ENOG4105BZP glycoside hydrolase 15-related Tpau_2784 ENOG4105DGW oligopeptidase A Tpau_2787 ENOG4105EA8 2-Nitropropane dioxygenase Tpau_2790 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Tpau_2792 ENOG4105C94 Transporter Tpau_2793 ENOG4105C26 Dehydrogenase Tpau_2800 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Tpau_2803 ENOG4105KQC Competence protein Tpau_2804 ENOG4107Z8D degv family Tpau_2805 ENOG4108TZC Tpau_2806 ENOG4105CVJ phosphoglycerate mutase Tpau_2808 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Tpau_2810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tpau_2813 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Tpau_2824 ENOG4107SVN transposase Tpau_2827 ENOG4105C1G acyl-Coa dehydrogenase Tpau_2828 ENOG4107QX3 carboxylase Tpau_2831 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase Tpau_2832 ENOG4108IG5 Transcriptional regulator Tpau_2834 ENOG4105DP4 dak2 domain fusion protein ylov Tpau_2835 ENOG4105VB9 50S ribosomal protein l28 Tpau_2841 ENOG4105CPF Cell wall formation (By similarity) Tpau_2842 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Tpau_2843 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) Tpau_2844 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Tpau_2847 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tpau_2848 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tpau_2851 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Tpau_2853 ENOG4105ERH Fumarylacetoacetate hydrolase Tpau_2854 ENOG4105E5T Major Facilitator Superfamily Tpau_2855 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tpau_2858 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_2861 ENOG4105URP P-aminobenzoate N-oxygenase AurF Tpau_2862 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Tpau_2863 ENOG4108ZP8 Acetolactate synthase small subunit Tpau_2866 ENOG4105C01 Dihydroxy-acid dehydratase Tpau_2867 ENOG4108VGI doxx family Tpau_2869 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tpau_2871 ENOG4105CTQ phosphohexokinase Tpau_2872 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_2873 ENOG4108ZGX Histidine kinase Tpau_2877 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Tpau_2880 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tpau_2882 ENOG4105C26 Dehydrogenase Tpau_2884 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_2886 ENOG4107SVN transposase Tpau_2887 ENOG4108Z86 Glutamine amidotransferase Tpau_2891 ENOG4105CT3 Monooxygenase Tpau_2892 ENOG4105NAE bifunctional deaminase-reductase domain protein Tpau_2895 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Tpau_2900 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Tpau_2909 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Tpau_2915 ENOG4105C9K Endothelin-converting enzyme 1 Tpau_2916 ENOG4105C10 Electron transfer flavoprotein Tpau_2918 ENOG4108KQJ Type 11 methyltransferase Tpau_2926 ENOG4105EVB acetyltransferase Tpau_2929 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Tpau_2935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tpau_2938 ENOG4105DKW ABC transporter Tpau_2939 ENOG4108IUM Glycogen debranching enzyme Tpau_2940 ENOG4105EAC phosphoserine phosphatase Tpau_2944 ENOG4105URP P-aminobenzoate N-oxygenase AurF Tpau_2955 ENOG4105F9F transposase Tpau_2958 ENOG4105J7D transcriptional regulator Tpau_2961 ENOG4105VT2 5-hydroxyisourate hydrolase Tpau_2962 ENOG41061H0 Monooxygenase Tpau_2965 ENOG4105C2W permease Tpau_2966 ENOG4107QUY Guanine deaminase Tpau_2968 ENOG4105C7W Xanthine dehydrogenase Tpau_2969 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Tpau_2970 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Tpau_2972 ENOG4108YYH Nadph-dependent fmn reductase Tpau_2976 ENOG4107QRP cobalamin biosynthesis protein CobW Tpau_2977 ENOG4105C72 UPF0176 protein Tpau_2979 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tpau_2981 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Tpau_2984 ENOG4105C6Y Udp-glucose 6-dehydrogenase Tpau_2986 ENOG4105UEI Transcriptional Regulator AraC Family Tpau_2988 ENOG4105MHT Transcriptional regulator, ARSR family Tpau_2996 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) Tpau_2998 ENOG41086S2 Tpau_2999 ENOG4108JU3 Alkyl hydroperoxide reductase Tpau_3000 ENOG4105D3R alkyl hydroperoxide reductase Tpau_3004 ENOG4105C6Z Gluconate Tpau_3005 ENOG4108UHU Aldolase Tpau_3009 ENOG4107HP6 Transcriptional regulator Tpau_3010 ENOG4105KME endoribonuclease L-psp Tpau_3011 ENOG4105PGM cation diffusion facilitator family transporter Tpau_3012 ENOG4107IFA Lipase (EC 3.1.1.3) Tpau_3014 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein Tpau_3020 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Tpau_3021 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Tpau_3022 ENOG4105CAK Cell division ATP-binding protein ftsE Tpau_3024 ENOG4105D8X mechanosensitive ion channel Tpau_3025 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Tpau_3027 ENOG4107TK4 histidinol-phosphate phosphatase Tpau_3028 ENOG4105C1G acyl-Coa dehydrogenase Tpau_3029 ENOG4105C1G acyl-Coa dehydrogenase Tpau_3030 ENOG4105CVP deoxyribo-dipyrimidine photolyase Tpau_3032 ENOG4105EYM Major Facilitator superfamily Tpau_3033 ENOG410635A Membrane Tpau_3034 ENOG4108UW5 maltose o-acetyltransferase Tpau_3036 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Tpau_3037 ENOG4105DJZ UPF0182 protein Tpau_3039 ENOG41063PX domain protein Tpau_3043 ENOG4105C1G acyl-Coa dehydrogenase Tpau_3044 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tpau_3051 ENOG4105KHC sulfurtransferase Tpau_3054 ENOG4108UCS ABC, transporter Tpau_3060 ENOG4106UW1 Major Facilitator superfamily Tpau_3064 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Tpau_3069 ENOG4105C1G acyl-Coa dehydrogenase Tpau_3070 ENOG4105C26 Dehydrogenase Tpau_3071 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tpau_3072 ENOG4105CJ1 ABC, transporter Tpau_3077 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 Tpau_3083 ENOG4108X0B nad(p)h dehydrogenase (quinone) Tpau_3089 ENOG4105K5X acetyltransferase Tpau_3101 ENOG4105C3G gtp-binding protein Tpau_3105 ENOG4105D22 carbon starvation protein Tpau_3108 ENOG4107SVN transposase Tpau_3109 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tpau_3114 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Tpau_3116 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tpau_3117 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tpau_3124 ENOG4107GFK fumarate Tpau_3128 ENOG4108IAB Phoh family Tpau_3130 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tpau_3132 ENOG4105CS9 pantothenic acid kinase Tpau_3136 ENOG4108IY8 ABC, transporter Tpau_3137 ENOG4106FTQ Taurine ABC transporter, periplasmic Tpau_3138 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Tpau_3141 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Tpau_3142 ENOG4105C7Z Conserved Protein Tpau_3143 ENOG4105EDW glycosyl transferase, family 39 Tpau_3145 ENOG4105T1M mycothiol conjugate amidase mca Tpau_3148 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Tpau_3149 ENOG4107T94 Endo-14-beta-xylanase Tpau_3158 ENOG4105NAE bifunctional deaminase-reductase domain protein Tpau_3165 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Tpau_3169 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tpau_3170 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Tpau_3171 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tpau_3173 ENOG4107QIZ NADH dehydrogenase Tpau_3174 ENOG4108IEH NADH dehydrogenase subunit g Tpau_3175 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Tpau_3176 ENOG41084C4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Tpau_3177 ENOG4107UFS subunit j Tpau_3178 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tpau_3181 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tpau_3183 ENOG4108IG5 Transcriptional regulator Tpau_3188 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 Tpau_3190 ENOG4105DXN mazG family Tpau_3194 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tpau_3201 ENOG4105EZR dyp-type peroxidase family protein Tpau_3203 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tpau_3208 ENOG4105MXB limonene-12-epoxide hydrolase Tpau_3209 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Tpau_3210 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Tpau_3212 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Tpau_3214 ENOG4105N14 lysine exporter protein LysE YggA Tpau_3225 ENOG4105C5H ABC transporter Tpau_3229 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein Tpau_3230 ENOG4105C5H ABC transporter Tpau_3231 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Tpau_3232 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Tpau_3233 ENOG4106839 domain protein Tpau_3234 ENOG4105F8V Hydrolase, tatD family Tpau_3244 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Tpau_3245 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Tpau_3246 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Tpau_3253 ENOG4107SVN transposase Tpau_3254 ENOG4105EW9 transcriptional regulator AsnC family Tpau_3255 ENOG4108UMN azlc family Tpau_3257 ENOG4105EV9 Alpha Beta Hydrolase Tpau_3263 ENOG4105KVH Transcriptional regulator Tpau_3264 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Tpau_3266 ENOG4105D9U N-acetyltransferase Tpau_3268 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tpau_3269 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase Tpau_3277 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Tpau_3283 ENOG4108RIR Molybdenum cofactor biosynthesis protein Tpau_3284 ENOG4105C0H protease Tpau_3287 ENOG4105EN6 Membrane Tpau_3289 ENOG4105NRA 50s ribosomal protein l31 type b Tpau_3291 ENOG4105KDC 50s ribosomal protein l28 Tpau_3292 ENOG4105W0E 50S ribosomal protein L33 Tpau_3293 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tpau_3294 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tpau_3298 ENOG4107KWJ von Willebrand factor, type A Tpau_3299 ENOG4105EET magnesium chelatase Tpau_3302 ENOG4105MHT Transcriptional regulator, ARSR family Tpau_3304 ENOG4105DC1 bifunctional purine biosynthesis protein purh Tpau_3309 ENOG4105EQ0 Major Facilitator superfamily Tpau_3311 ENOG4105CMV Succinyl-CoA synthetase subunit beta Tpau_3315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tpau_3316 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_3319 ENOG4105C1G acyl-Coa dehydrogenase Tpau_3321 ENOG4107QX3 carboxylase Tpau_3326 ENOG4105DR5 peptidase Tpau_3335 ENOG4105E6M Sulphatase-modifying factor protein Tpau_3336 ENOG41061MV Arylsulfatase Tpau_3338 ENOG4107QP8 phosphohexose isomerase Tpau_3343 ENOG4108VW9 Membrane Tpau_3347 ENOG4105DBE peroxidase Tpau_3348 ENOG4105EKT )-iron permease Tpau_3350 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Tpau_3357 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tpau_3359 ENOG4107RN3 metallophosphoesterase Tpau_3364 ENOG4105E1J oxidoreductase Tpau_3380 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Tpau_3381 ENOG4108ZT0 50S ribosomal protein l17 Tpau_3382 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tpau_3383 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Tpau_3384 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Tpau_3385 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Tpau_3386 ENOG41067V7 50S ribosomal protein L36 Tpau_3388 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Tpau_3389 ENOG4105PTV Nudix Hydrolase Tpau_3393 ENOG4107TXC Transcriptional regulator Tpau_3394 ENOG4107QJT sodium dicarboxylate symporter Tpau_3396 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Tpau_3398 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Tpau_3399 ENOG410849U 50S ribosomal protein L30 Tpau_3400 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Tpau_3401 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Tpau_3402 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Tpau_3403 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Tpau_3406 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Tpau_3407 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Tpau_3409 ENOG4105CQM Urea amidohydrolase subunit alpha Tpau_3410 ENOG4105KI2 Urea amidohydrolase subunit beta Tpau_3411 ENOG4108YZ9 Urea amidohydrolase subunit gamma Tpau_3418 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tpau_3419 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Tpau_3420 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Tpau_3421 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Tpau_3424 ENOG4105C1J atp-dependent rna helicase Tpau_3426 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Tpau_3427 ENOG41082SA 50s ribosomal protein l29 Tpau_3428 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Tpau_3429 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Tpau_3431 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Tpau_3432 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Tpau_3433 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Tpau_3434 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Tpau_3435 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Tpau_3444 ENOG4107RN6 Monooxygenase Tpau_3459 ENOG4105F9F transposase Tpau_3463 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) Tpau_3466 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Tpau_3467 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tpau_3468 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Tpau_3469 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Tpau_3472 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Tpau_3494 ENOG4108IG5 Transcriptional regulator Tpau_3497 ENOG4108M15 ABC transporter Tpau_3501 ENOG4107SVN transposase Tpau_3504 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_3507 ENOG4105WH1 Two component transcriptional regulator luxr family Tpau_3509 ENOG4107STQ Multicopper oxidase Tpau_3513 ENOG4105F95 Monooxygenase Tpau_3517 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Tpau_3519 ENOG4105CSH Transporter Tpau_3522 ENOG4108KPJ rna polymerase sigma factor Tpau_3525 ENOG4108MJN Glycosyl Transferase Tpau_3526 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tpau_3527 ENOG4105BZ7 extracellular solute-binding protein family 1 Tpau_3540 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tpau_3543 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Tpau_3544 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Tpau_3545 ENOG4107NHD transcriptional regulator Tpau_3547 ENOG4105KHC sulfurtransferase Tpau_3548 ENOG4105PKJ carbohydrate binding Tpau_3550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tpau_3551 ENOG4105CF1 Alkylated DNA repair protein Tpau_3553 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Tpau_3554 ENOG4105DBI uridine monophosphokinase Tpau_3556 ENOG4105C2J ABC transporter Tpau_3557 ENOG4105CNN ABC, transporter Tpau_3558 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator Tpau_3561 ENOG4108SVG May play a role in the intracellular transport of hydrophobic ligands Tpau_3566 ENOG4108JJ8 (ABC) transporter Tpau_3567 ENOG4108JJ9 ABC, transporter Tpau_3568 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Tpau_3572 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tpau_3575 ENOG4105CXB phosphoribosylaminoimidazole synthetase Tpau_3582 ENOG4105ECP epimerase Tpau_3585 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Tpau_3591 ENOG4105C85 amino acid Tpau_3592 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Tpau_3594 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Tpau_3595 ENOG4107QJT sodium dicarboxylate symporter Tpau_3596 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Tpau_3597 ENOG4108MRH transcriptional regulatory protein Tpau_3602 ENOG4105DEF Extracellular solute-binding protein, family 5 Tpau_3605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tpau_3606 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Tpau_3609 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Tpau_3610 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tpau_3611 ENOG4105C85 amino acid Tpau_3612 ENOG4105DFM M18 family aminopeptidase Tpau_3613 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tpau_3614 ENOG410839H phosphoribosylformylglycinamidine synthase Tpau_3617 ENOG4108V06 Glutathione peroxidase Tpau_3619 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tpau_3622 ENOG4105C8V SAICAR synthetase Tpau_3624 ENOG4105C83 adenylosuccinate lyase Tpau_3630 ENOG4105BZU Histidine kinase Tpau_3631 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tpau_3633 ENOG4105EUB pirin domain protein Tpau_3634 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Tpau_3638 ENOG4105E39 Enoyl-CoA hydratase Tpau_3642 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Tpau_3646 ENOG4107R4N Cell wall formation (By similarity) Tpau_3653 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Tpau_3654 ENOG4105CIY formyltetrahydrofolate deformylase Tpau_3655 ENOG4105GCF PGAM Tpau_3656 ENOG4105F2Z 3-oxoadipate enol-lactonase Tpau_3660 ENOG4106BRA Membrane Tpau_3661 ENOG4105CSR polyphosphate kinase 2 Tpau_3663 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Tpau_3664 ENOG4105CN8 Transcriptional regulator Tpau_3665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tpau_3666 ENOG4105C3M thioredoxin reductase Tpau_3668 ENOG4107RPH Isocitrate lyase Tpau_3672 ENOG4105EV8 ectoine hydroxylase Tpau_3681 ENOG4105CSR polyphosphate kinase 2 Tpau_3684 ENOG4105WQI isochorismatase Tpau_3685 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Tpau_3686 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase Tpau_3687 ENOG4105Q26 Siderophore-interacting protein Tpau_3688 ENOG4105BZ1 (ABC) transporter Tpau_3689 ENOG4105BZ1 (ABC) transporter Tpau_3692 ENOG4105WQI isochorismatase Tpau_3693 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_3696 ENOG4108V5C ABC transporter Tpau_3697 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_3701 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Tpau_3702 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tpau_3706 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Tpau_3708 ENOG4105Y3U Transglycosylase-associated protein Tpau_3709 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme Tpau_3714 ENOG4105D65 subunit l Tpau_3715 ENOG4105MKQ Monovalent cation H antiporter subunit C Tpau_3716 ENOG4108JPZ Monovalent cation H antiporter subunit D Tpau_3719 ENOG4105KJM monovalent cation h antiporter subunit g Tpau_3720 ENOG4105C6T cysteine synthase Tpau_3725 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Tpau_3726 ENOG4105EHG Permease protein Tpau_3727 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Tpau_3731 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tpau_3732 ENOG4108HJF gCN5-related N-acetyltransferase Tpau_3735 ENOG4108IUW ABC transporter Tpau_3737 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Tpau_3739 ENOG4105DWF phosphomethylpyrimidine kinase Tpau_3742 ENOG4105CIG ABC transporter Tpau_3744 ENOG4105CSH Transporter Tpau_3746 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tpau_3748 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tpau_3749 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tpau_3750 ENOG4105KVH Transcriptional regulator Tpau_3754 ENOG4105CT1 (ABC) transporter Tpau_3756 ENOG4105E0A ABC, transporter Tpau_3757 ENOG4105TVJ transport system, permease Tpau_3758 ENOG4105DQ5 transport system permease protein Tpau_3761 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Tpau_3763 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Tpau_3765 ENOG4105BZ1 (ABC) transporter Tpau_3774 ENOG4105DQ5 transport system permease protein Tpau_3775 ENOG4105E0A ABC, transporter Tpau_3776 ENOG4106A3M Cytochrome p-450 Tpau_3786 ENOG4105CHP RNA polymerase Tpau_3787 ENOG4105C1B dTDP-glucose 4-6-dehydratase Tpau_3788 ENOG4108SGK Tetr family transcriptional regulator Tpau_3789 ENOG4105CY3 ABC transporter, permease Tpau_3797 ENOG4105D2B acyl-CoA dehydrogenase Tpau_3802 ENOG4107HP6 Transcriptional regulator Tpau_3805 ENOG4105CHR reductase Tpau_3806 ENOG4105X7H acyl-CoA dehydrogenase Tpau_3807 ENOG4108KC2 acyl-Coa dehydrogenase Tpau_3808 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Tpau_3810 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) Tpau_3812 ENOG4105DYW oxidoreductase Tpau_3821 ENOG4106A3M Cytochrome p-450 Tpau_3822 ENOG4105F2C Acetyl-CoA acetyltransferase Tpau_3824 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Tpau_3826 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Tpau_3829 ENOG4105EA8 2-Nitropropane dioxygenase Tpau_3831 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Tpau_3832 ENOG4105F2C Acetyl-CoA acetyltransferase Tpau_3833 ENOG4108RZE Tetr family transcriptional regulator Tpau_3834 ENOG4105CHR reductase Tpau_3835 ENOG4105CC9 acyl-Coa dehydrogenase Tpau_3836 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_3838 ENOG4105CC9 acyl-Coa dehydrogenase Tpau_3840 ENOG4105D2B acyl-CoA dehydrogenase Tpau_3841 ENOG4108XZR Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Tpau_3842 ENOG4105MXW flavin reductase domain protein, FMN-binding Tpau_3843 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase Tpau_3844 ENOG41088PD hydrolase Tpau_3845 ENOG4108KC1 acyl-Coa dehydrogenase Tpau_3846 ENOG4107EFR Flavocytochrome c Tpau_3848 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Tpau_3849 ENOG4105CIJ rieske 2fe-2S domain-containing protein Tpau_3855 ENOG4105X7H acyl-CoA dehydrogenase Tpau_3856 ENOG410900P UPF0336 protein Tpau_3869 ENOG4105G9B Transcriptional regulator Tpau_3870 ENOG4105CT3 Monooxygenase Tpau_3874 ENOG4107QRG dna polymerase iii Tpau_3876 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Tpau_3879 ENOG4105F9F transposase Tpau_3880 ENOG4105VEQ Cold shock protein Tpau_3881 ENOG4108I5C dEAD DEAH box helicase Tpau_3901 ENOG4107SVN transposase Tpau_3904 ENOG4108SVB resolvase Tpau_3913 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tpau_3914 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tpau_3915 ENOG4108J59 Extracellular solute-binding protein, family 5 Tpau_3916 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tpau_3919 ENOG4105CJ1 ABC, transporter Tpau_3923 ENOG4105CSH Transporter Tpau_3924 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Tpau_3926 ENOG4107S9D Alpha beta hydrolase Tpau_3928 ENOG4105P8F nudix hydrolase Tpau_3933 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tpau_3941 ENOG4105E39 Enoyl-CoA hydratase Tpau_3943 ENOG4108JGH Tetr family transcriptional regulator Tpau_3945 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tpau_3949 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tpau_3950 ENOG4108HHA Transketolase Tpau_3951 ENOG4105EW9 transcriptional regulator AsnC family Tpau_3952 ENOG4105C26 Dehydrogenase Tpau_3959 ENOG4105DIN metallophosphoesterase Tpau_3960 ENOG4105KTH gatB Yqey Tpau_3962 ENOG4108680 CrcB-like protein Tpau_3964 ENOG4108ZHJ Organic hydroperoxide resistance protein Tpau_3969 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_3971 ENOG4106NZI LysR family Transcriptional regulator Tpau_3973 ENOG4105CJN penicillin-binding protein Tpau_3975 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Tpau_3978 ENOG41090A1 ferritin Tpau_3979 ENOG4107Z3H Transcriptional regulator, TetR family Tpau_3981 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Tpau_3982 ENOG4105CFH Aspartokinase Tpau_3985 ENOG4105WQT MbtH domain protein Tpau_3988 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tpau_3989 ENOG4105T38 integral membrane protein Tpau_3990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tpau_3998 ENOG4105CSH Transporter Tpau_3999 ENOG4105JQN Transcriptional regulator Tpau_4000 ENOG4108594 Permease of the drug metabolite transporter Tpau_4002 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Tpau_4004 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Tpau_4008 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Tpau_4010 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase Tpau_4011 ENOG4105C34 Pseudouridine synthase Tpau_4014 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Tpau_4018 ENOG4105G6Z alkaline phosphatase Tpau_4021 ENOG4105XT2 Transcriptional regulator Tpau_4023 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 Tpau_4026 ENOG4108WC5 Alpha Beta Hydrolase Fold protein Tpau_4032 ENOG41082YX Transcriptional regulator, arsr family Tpau_4034 ENOG4105C7K acetolactate synthase Tpau_4035 ENOG4105CI2 imidazolone-5-propionate hydrolase Tpau_4036 ENOG4105CSH Transporter Tpau_4038 ENOG4105DQE DNA ligase Tpau_4039 ENOG4105GN4 DNA ligase Tpau_4042 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Tpau_4043 ENOG4105ECQ AraC Family Transcriptional Regulator Tpau_4044 ENOG4105EYF MMPL domain protein Tpau_4048 ENOG4108Z6B deaminase Tpau_4050 ENOG4105EVN Prephenate dehydrogenase Tpau_4055 ENOG4105F9F transposase Tpau_4057 ENOG4107RR1 TRANSCRIPTIONal Tpau_4058 ENOG4105C26 Dehydrogenase Tpau_4060 ENOG4108Z8I decarboxylase Tpau_4071 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Tpau_4075 ENOG4105CIH Imidazole acetol-phosphate transaminase Tpau_4079 ENOG4105ECQ AraC Family Transcriptional Regulator Tpau_4088 ENOG4105F9F transposase Tpau_4099 ENOG4108VC7 Protein of unknown function (DUF2587) Tpau_4102 ENOG4108MKI Glycosyl transferase, family 2 Tpau_4103 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_4108 ENOG4105VZ8 Transcriptional regulator Tpau_4110 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tpau_4113 ENOG4108JPW Aminotransferase Tpau_4117 ENOG4105C1G acyl-Coa dehydrogenase Tpau_4118 ENOG4108X07 Tetr family transcriptional regulator Tpau_4119 ENOG4105IQ5 FAD linked oxidase domain protein Tpau_4120 ENOG4108RG3 short-chain dehydrogenase reductase Tpau_4122 ENOG4105PDP Short chain dehydrogenase Tpau_4123 ENOG4108MES Periplasmic binding protein Tpau_4130 ENOG4108JJB ABC transporter Tpau_4131 ENOG4107ZYJ bioY protein Tpau_4133 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Tpau_4137 ENOG4105J1Z Arabinosyltransferase Tpau_4138 ENOG4108NUW Cell wall arabinan synthesis protein Tpau_4139 ENOG4105J1Z Arabinosyltransferase Tpau_4141 ENOG4105EBR Carboxylesterase Tpau_4142 ENOG4105C94 Transporter Tpau_4150 ENOG4105E90 ABC transporter Tpau_4151 ENOG4108IJ8 ABC transporter Tpau_4152 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component Tpau_4155 ENOG4105KAV tspo and mbr like protein Tpau_4161 ENOG4105E1F short-chain dehydrogenase reductase Tpau_4166 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Tpau_4167 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tpau_4169 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) Tpau_4182 ENOG4105CHU acetyl-coa acetyltransferase Tpau_4185 ENOG4108UKI Enoyl-CoA hydratase Tpau_4186 ENOG4105EA8 2-Nitropropane dioxygenase Tpau_4192 ENOG4105BZ4 penicillin-binding protein Tpau_4195 ENOG4105CZA synthase Tpau_4197 ENOG4105EPD Oligopeptide transporter, Opt family Tpau_4198 ENOG4105DYW oxidoreductase Tpau_4203 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Tpau_4204 ENOG4105DXB Major Facilitator superfamily Tpau_4206 ENOG4105E2R ROK family Tpau_4207 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Tpau_4208 ENOG4105C01 Dihydroxy-acid dehydratase Tpau_4209 ENOG4108UHU Aldolase Tpau_4210 ENOG4108HWW ABC transporter Tpau_4211 ENOG4105C2J ABC transporter Tpau_4212 ENOG4105DFW ABC transporter Tpau_4214 ENOG4105C8T Leucyl-tRNA synthetase Tpau_4216 ENOG4105DHU Bile acid Tpau_4228 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tpau_4229 ENOG4105C26 Dehydrogenase Tpau_4233 ENOG4105K63 Thioredoxin Tpau_4234 ENOG4108E1C hydrolase Tpau_4237 ENOG4107QJE Chromosome Partitioning Protein Tpau_4238 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Tpau_4241 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Tpau_4242 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Tpau_4253 ENOG4108PJD permease Tpau_4268 ENOG4105D5G Transposase Tpau_4269 ENOG4107SVN transposase Tpau_4276 ENOG4105D5G Transposase Tpau_4284 ENOG4105D5G Transposase Tpau_4286 ENOG4105D5G Transposase Tpau_4287 ENOG4105D5G Transposase Tpau_4295 ENOG4107QJE Chromosome Partitioning Protein Tpau_4300 ENOG41086VY Fic/DOC family Tpau_4304 ENOG4105D5G Transposase Tpau_4306 ENOG4105CHH sulfate transporter Tpau_4320 ENOG4105CEY Amp-dependent synthetase and ligase Tpau_4321 ENOG4107EEY synthase Tpau_4325 ENOG4107D0A Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro Tpau_4326 ENOG4105C0W non-ribosomal peptide synthetase Tpau_4331 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Tpau_4335 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases